tweety homolog 1 (Drosophila), isoform CRA_g [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Tweety_N super family | cl12141 | N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ... |
6-42 | 6.37e-14 | ||
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins. The actual alignment was detected with superfamily member cd07912: Pssm-ID: 472281 Cd Length: 418 Bit Score: 65.81 E-value: 6.37e-14
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| Name | Accession | Description | Interval | E-value | ||
| Tweety_N | cd07912 | N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ... |
6-42 | 6.37e-14 | ||
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins. Pssm-ID: 143653 Cd Length: 418 Bit Score: 65.81 E-value: 6.37e-14
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| Tweety | pfam04906 | Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ... |
9-42 | 1.57e-13 | ||
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in. Pssm-ID: 461475 Cd Length: 429 Bit Score: 64.68 E-value: 1.57e-13
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| Name | Accession | Description | Interval | E-value | ||
| Tweety_N | cd07912 | N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a ... |
6-42 | 6.37e-14 | ||
N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; The protein product of the Drosophila tweety (tty) gene is thought to form a trans-membrane protein with five membrane-spanning regions and a cytoplasmic C-terminus. This N-terminal domain contains the putative transmembrane spanning regions. Tweety has been suggested as a candidate for a large conductance chloride channel, both in vertebrate and insect cells. Three human homologs have been identified and designated TTYH1-3. TTYH2 has been associated with the progression of cancer, and Drosophila melanogaster tweety has been assumed to play a role in development. TTYH2, and TTYH3 bind to and are ubiquinated by Nedd4-2, a HECT type E3 ubiquitin ligase, which most likely plays a role in controlling the cellular levels of tweety family proteins. Pssm-ID: 143653 Cd Length: 418 Bit Score: 65.81 E-value: 6.37e-14
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| Tweety | pfam04906 | Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is ... |
9-42 | 1.57e-13 | ||
Tweety; The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in. Pssm-ID: 461475 Cd Length: 429 Bit Score: 64.68 E-value: 1.57e-13
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