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Conserved domains on  [gi|119591354|gb|EAW70948|]
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proteasome (prosome, macropain) 26S subunit, non-ATPase, 1, isoform CRA_b, partial [Homo sapiens]

Protein Classification

26S proteasome non-ATPase regulatory subunit 1( domain architecture ID 1001948)

26S proteasome non-ATPase regulatory subunit 1 (PSMD1), also known as RPN2, is a non-ATPase subunit of the 19S regulatory complex of the 26S proteasome which plays a critical role in the recognition of ubiquitinated protein substrates by the proteasome and is involved in the ATP-dependent unfolding and translocation of these substrates into the proteasome core for degradation

Gene Ontology:  GO:0043161|GO:0005838

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPN2 super family cl34911
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 2-808 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5116:

Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 815.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354   2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYA 81
Cdd:COG5116    3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354  82 LGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVEnADLpEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLD 161
Cdd:COG5116   83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDS-AYI-GGDKDIIDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 162 VFEKTILESNDVpGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDN 241
Cdd:COG5116  161 IIEKYLSDGNDC-DIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKLVKEND 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 242 LLMAYQICFDLYESASQQFLSSVIqnlrtvgtpiasvpgstnTGTVPGSEKDsdsmeteektssafvgktpeaspepkdq 321
Cdd:COG5116  240 LLLYAQVAFDLEDSASQEILEILV------------------TELVAQGYDQ---------------------------- 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 322 tlKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV--RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNW 399
Cdd:COG5116  274 --AVMSILSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLarKFSRFHYAVSLANSFMNLGTSNDSFYRNNLDWLGKASNW 351

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 400 AKFTATASLGVIHKGHEKEALQLMATYLPKDTSpGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASN---DIVRHG 476
Cdd:COG5116  352 AKFTATASLGVIHLGNSNPGYEILKPYLPSEVA-SSRQKEGGALYALGLIKAGFGREDTEYLLEYFLDTEDeltPELAYG 430

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 477 GSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVM 556
Cdd:COG5116  431 VCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGETQHERIKRGLGIGFALIL 510

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 557 YGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSV 636
Cdd:COG5116  511 YGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAVIALGFVCCDDRDLLVGT 590

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 637 VSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKV 716
Cdd:COG5116  591 VELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCNPELNPNVKRIIKKFNRV 670

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 717 INDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDL- 795
Cdd:COG5116  671 IVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFVSLSFLPTTVIGIRGSQa 750

                        810       820       830       840
                 ....*....|....*....|....*....|....*....|...
gi 119591354 796 ------------------------------KVSTAVLSITAKA 808
Cdd:COG5116  751 ipkfcfnedleeeefeyprmyeeasgksvrKVNTAVLSTTIKA 793
 
Name Accession Description Interval E-value
RPN2 COG5116
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 2-808 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 815.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354   2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYA 81
Cdd:COG5116    3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354  82 LGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVEnADLpEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLD 161
Cdd:COG5116   83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDS-AYI-GGDKDIIDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 162 VFEKTILESNDVpGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDN 241
Cdd:COG5116  161 IIEKYLSDGNDC-DIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKLVKEND 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 242 LLMAYQICFDLYESASQQFLSSVIqnlrtvgtpiasvpgstnTGTVPGSEKDsdsmeteektssafvgktpeaspepkdq 321
Cdd:COG5116  240 LLLYAQVAFDLEDSASQEILEILV------------------TELVAQGYDQ---------------------------- 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 322 tlKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV--RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNW 399
Cdd:COG5116  274 --AVMSILSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLarKFSRFHYAVSLANSFMNLGTSNDSFYRNNLDWLGKASNW 351

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 400 AKFTATASLGVIHKGHEKEALQLMATYLPKDTSpGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASN---DIVRHG 476
Cdd:COG5116  352 AKFTATASLGVIHLGNSNPGYEILKPYLPSEVA-SSRQKEGGALYALGLIKAGFGREDTEYLLEYFLDTEDeltPELAYG 430

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 477 GSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVM 556
Cdd:COG5116  431 VCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGETQHERIKRGLGIGFALIL 510

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 557 YGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSV 636
Cdd:COG5116  511 YGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAVIALGFVCCDDRDLLVGT 590

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 637 VSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKV 716
Cdd:COG5116  591 VELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCNPELNPNVKRIIKKFNRV 670

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 717 INDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDL- 795
Cdd:COG5116  671 IVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFVSLSFLPTTVIGIRGSQa 750

                        810       820       830       840
                 ....*....|....*....|....*....|....*....|...
gi 119591354 796 ------------------------------KVSTAVLSITAKA 808
Cdd:COG5116  751 ipkfcfnedleeeefeyprmyeeasgksvrKVNTAVLSTTIKA 793
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 599-690 1.61e-12

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 63.90  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354  599 IRRLLHVAVSDVNDDVRRAAVESLGfiLFRTPEQCPSVVSLLSESyNPHVRYGAAMALGIccagTGNKEAINLLEPM-TN 677
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALG--RIGDPEAVPALLELLKDE-DPAVRRAAAEALGK----IGDPEALPALLELlRD 73

                          90
                  ....*....|...
gi 119591354  678 DPVNYVRQGALIA 690
Cdd:pfam13646  74 DDDDVVRAAAAEA 86
 
Name Accession Description Interval E-value
RPN2 COG5116
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 2-808 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 815.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354   2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYA 81
Cdd:COG5116    3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354  82 LGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVEnADLpEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLD 161
Cdd:COG5116   83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDS-AYI-GGDKDIIDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 162 VFEKTILESNDVpGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDN 241
Cdd:COG5116  161 IIEKYLSDGNDC-DIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKLVKEND 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 242 LLMAYQICFDLYESASQQFLSSVIqnlrtvgtpiasvpgstnTGTVPGSEKDsdsmeteektssafvgktpeaspepkdq 321
Cdd:COG5116  240 LLLYAQVAFDLEDSASQEILEILV------------------TELVAQGYDQ---------------------------- 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 322 tlKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV--RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNW 399
Cdd:COG5116  274 --AVMSILSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLarKFSRFHYAVSLANSFMNLGTSNDSFYRNNLDWLGKASNW 351

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 400 AKFTATASLGVIHKGHEKEALQLMATYLPKDTSpGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASN---DIVRHG 476
Cdd:COG5116  352 AKFTATASLGVIHLGNSNPGYEILKPYLPSEVA-SSRQKEGGALYALGLIKAGFGREDTEYLLEYFLDTEDeltPELAYG 430

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 477 GSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVM 556
Cdd:COG5116  431 VCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGETQHERIKRGLGIGFALIL 510

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 557 YGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSV 636
Cdd:COG5116  511 YGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAVIALGFVCCDDRDLLVGT 590

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 637 VSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKV 716
Cdd:COG5116  591 VELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCNPELNPNVKRIIKKFNRV 670

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 717 INDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDL- 795
Cdd:COG5116  671 IVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFVSLSFLPTTVIGIRGSQa 750

                        810       820       830       840
                 ....*....|....*....|....*....|....*....|...
gi 119591354 796 ------------------------------KVSTAVLSITAKA 808
Cdd:COG5116  751 ipkfcfnedleeeefeyprmyeeasgksvrKVNTAVLSTTIKA 793
RPN1 COG5110
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 373-801 1.95e-25

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227441 [Multi-domain]  Cd Length: 881  Bit Score: 113.10  E-value: 1.95e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 373 NSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSpgsaYQEGGGLYALGLIH-A 451
Cdd:COG5110  368 NDPINLGYENDSLIPLDDEWIYKCKVPGLISAFASIGVIESWNSDKGLETLDKYLYADES----YRKAGALLGIGLSGlR 443

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 452 NHG-GDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEA--AGLALGLVMLGSKNAQA 528
Cdd:COG5110  444 VFEeRPPALALLSNYLQSSSSKHVIAAILGLGAAFSGTQAEEVLELLQPIMFSTDSPIEVVffASLTLGSVFVGTCNGDL 523

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 529 IEDMV-------GYAQETQhekILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRR 601
Cdd:COG5110  524 TSLILqtfvergKIESETQ---WFRFLALGLASLFYGRKDQVDDVEETIMAIEGALSKHEEILVKGCQYVGTGDVLVIQS 600

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 602 LLHVAVSDVNDDVRR--AAVES---LGFILFRTPEQCPSVVSLLSESY-----NPHVRYGAAMALGICCAGTGNKEAINL 671
Cdd:COG5110  601 LLHVKDEFTGDTLKNeeALIESlalLGCALIAMGEDIGSEMVLRHFSHsmhygSSHIRSVLPLAYGILSPSNPQMNVFDT 680

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 672 LEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVnqFRQLYSKVindkHDDVMAKFGAILAQGILDAGGHNVTISLQSR 751
Cdd:COG5110  681 LERSSHDGDLNVIINTIFAMGLIGAGTLNARLAQL--LRQLASYY----YKESKALFVLRIAQGLLSLGKGTMTISPLYF 754

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119591354 752 TGHTHMPSVVGVLVFTQFWFW----FPL--SH----FLSLAYTPTCVIGLNKD---LKVSTAV 801
Cdd:COG5110  755 DKTTLMPKNTAGLFTTVFMLLdssiFPLvsSHalmyFLLCQIRPQKYVTLSEKgepIKVNVRV 817
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 599-690 1.61e-12

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 63.90  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354  599 IRRLLHVAVSDVNDDVRRAAVESLGfiLFRTPEQCPSVVSLLSESyNPHVRYGAAMALGIccagTGNKEAINLLEPM-TN 677
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALG--RIGDPEAVPALLELLKDE-DPAVRRAAAEALGK----IGDPEALPALLELlRD 73

                          90
                  ....*....|...
gi 119591354  678 DPVNYVRQGALIA 690
Cdd:pfam13646  74 DDDDVVRAAAAEA 86
HEAT COG1413
HEAT repeat [General function prediction only];
545-690 4.00e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 64.26  E-value: 4.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 545 LRGLAVGiALVMYGRMEEADALIESLcRDKDPILRRSGMYTVAMAycgsGNNKAIRRLLHvAVSDVNDDVRRAAVESLGF 624
Cdd:COG1413    1 VRRAAAR-ALGRLGDPAAVPALIAAL-ADEDPDVRAAAARALGRL----GDPRAVPALLE-ALKDPDPEVRAAAAEALGR 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119591354 625 IlfRTPEQCPSVVSLLSESyNPHVRYGAAMALGiccaGTGNKEAINLLEPMTNDPVNYVRQGALIA 690
Cdd:COG1413   74 I--GDPEAVPALIAALKDE-DPEVRRAAAEALG----RLGDPAAVPALLEALKDPDWEVRRAAARA 132
HEAT COG1413
HEAT repeat [General function prediction only];
510-657 2.14e-10

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 59.26  E-value: 2.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 510 EAAGLALGLVmlgsKNAQAIEDMVGYAQETQHEkiLRGLAVgIALVMYGRMEEADALIESLcRDKDPILRRSgmytVAMA 589
Cdd:COG1413    3 RAAARALGRL----GDPAAVPALIAALADEDPD--VRAAAA-RALGRLGDPRAVPALLEAL-KDPDPEVRAA----AAEA 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119591354 590 YCGSGNNKAIRRLLHvAVSDVNDDVRRAAVESLGFIlfRTPEQCPSVVSLLSESyNPHVRYGAAMALG 657
Cdd:COG1413   71 LGRIGDPEAVPALIA-ALKDEDPEVRRAAAEALGRL--GDPAAVPALLEALKDP-DWEVRRAAARALG 134
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 563-657 3.25e-10

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 57.35  E-value: 3.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354  563 ADALIESLCRDKDPILRRsgmyTVAMAyCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFIlfRTPEQCPSVVSLLSE 642
Cdd:pfam13646   1 LPALLQALLRDPDPEVRA----AAIRA-LGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKI--GDPEALPALLELLRD 73

                          90
                  ....*....|....*
gi 119591354  643 SYNPHVRYGAAMALG 657
Cdd:pfam13646  74 DDDDVVRAAAAEALA 88
PC_rep pfam01851
Proteasome/cyclosome repeat;
651-685 8.36e-07

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 45.87  E-value: 8.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 119591354  651 GAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQ 685
Cdd:pfam01851   1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
HEAT COG1413
HEAT repeat [General function prediction only];
614-694 1.07e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.78  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591354 614 VRRAAVESLGFIlfRTPEQCPSVVSLLSESyNPHVRYGAAMALGiccaGTGNKEAINLLEPMTNDPVNYVRQGALIASAL 693
Cdd:COG1413    1 VRRAAARALGRL--GDPAAVPALIAALADE-DPDVRAAAARALG----RLGDPRAVPALLEALKDPDPEVRAAAAEALGR 73


                 .
gi 119591354 694 I 694
Cdd:COG1413   74 I 74
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 545-623 2.00e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 40.78  E-value: 2.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119591354  545 LRGLAVgIALVMYGRMEEADALIEsLCRDKDPILRRsgmyTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLG 623
Cdd:pfam13646  16 VRAAAI-RALGRIGDPEAVPALLE-LLKDEDPAVRR----AAAEALGKIGDPEALPALLELLRDDDDDVVRAAAAEALA 88
PC_rep pfam01851
Proteasome/cyclosome repeat;
511-544 2.06e-04

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 39.33  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 119591354  511 AAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKI 544
Cdd:pfam01851   1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESR 34
PC_rep pfam01851
Proteasome/cyclosome repeat;
476-510 8.99e-04

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 37.40  E-value: 8.99e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 119591354  476 GGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGE 510
Cdd:pfam01851   1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
PC_rep pfam01851
Proteasome/cyclosome repeat;
441-474 9.17e-04

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 37.40  E-value: 9.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 119591354  441 GGLYALGLIHANHG-GDIIDYLLNQLKNASNDIVR 474
Cdd:pfam01851   1 GAALALGLIHAGSGnEEALDLLLPYLSDTSAESRA 35
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 646-690 2.06e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.96  E-value: 2.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119591354  646 PHVRYGAAMALGICCAGTGN------KEAINLLEPMTNDPVNYVRQGALIA 690
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDllapavPELLPALLPLLNDDSDLVREAAAWA 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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