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Conserved domains on  [gi|119587977|gb|EAW67573|]
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loss of heterozygosity, 11, chromosomal region 2, gene A, isoform CRA_c [Homo sapiens]

Protein Classification

VIT domain-containing protein( domain architecture ID 10652052)

VIT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VIT smart00609
Vault protein Inter-alpha-Trypsin domain;
1-131 3.60e-53

Vault protein Inter-alpha-Trypsin domain;


:

Pssm-ID: 197803 [Multi-domain]  Cd Length: 130  Bit Score: 168.69  E-value: 3.60e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119587977     1 MVHFCGLLTLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEkVPLEAFFVFPMDEDSAVYSFEAL-VDGKKIVAELQD 79
Cdd:smart00609   1 LSGKRGLQTAEVNGVPLYSLKVNSKVTSRFAHTVVTSRVVNRA-VPAQEVTFDVELPKTAFISNFAMtIDGKTYVGEIKE 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 119587977    80 KMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVgNLQPGSKAAVTLKYVQ 131
Cdd:smart00609  80 KEVAQKQYEKAVSQGKTAGLVRASGRSMEQFTVSV-NVAPGSKVTFELTYEE 130
 
Name Accession Description Interval E-value
VIT smart00609
Vault protein Inter-alpha-Trypsin domain;
1-131 3.60e-53

Vault protein Inter-alpha-Trypsin domain;


Pssm-ID: 197803 [Multi-domain]  Cd Length: 130  Bit Score: 168.69  E-value: 3.60e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119587977     1 MVHFCGLLTLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEkVPLEAFFVFPMDEDSAVYSFEAL-VDGKKIVAELQD 79
Cdd:smart00609   1 LSGKRGLQTAEVNGVPLYSLKVNSKVTSRFAHTVVTSRVVNRA-VPAQEVTFDVELPKTAFISNFAMtIDGKTYVGEIKE 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 119587977    80 KMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVgNLQPGSKAAVTLKYVQ 131
Cdd:smart00609  80 KEVAQKQYEKAVSQGKTAGLVRASGRSMEQFTVSV-NVAPGSKVTFELTYEE 130
VIT pfam08487
Vault protein inter-alpha-trypsin domain; Inter-alpha-trypsin inhibitors (ITIs) consist of one ...
 17-129 8.24e-41

Vault protein inter-alpha-trypsin domain; Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilization and tumour metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.


Pssm-ID: 462492 [Multi-domain]  Cd Length: 111  Bit Score: 136.46  E-value: 8.24e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119587977   17 LKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIVAELQDKMKARTNYEKAISQGHQ 96
Cdd:pfam08487   1 LKSVSVDATITGRIARTTVTQTFVNPSNEALEAVYVFPLPEGAAVSGFTMTIGGKVIVGEVKEKEEAKKEYEEAVARGKT 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 119587977   97 AFLLEgdSSSRDVFSCNVGNLQPGSKAAVTLKY 129
Cdd:pfam08487  81 AGLLE--QDTPDVFTTSVGNIPPGEKVTVELTY 111
 
Name Accession Description Interval E-value
VIT smart00609
Vault protein Inter-alpha-Trypsin domain;
1-131 3.60e-53

Vault protein Inter-alpha-Trypsin domain;


Pssm-ID: 197803 [Multi-domain]  Cd Length: 130  Bit Score: 168.69  E-value: 3.60e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119587977     1 MVHFCGLLTLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEkVPLEAFFVFPMDEDSAVYSFEAL-VDGKKIVAELQD 79
Cdd:smart00609   1 LSGKRGLQTAEVNGVPLYSLKVNSKVTSRFAHTVVTSRVVNRA-VPAQEVTFDVELPKTAFISNFAMtIDGKTYVGEIKE 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 119587977    80 KMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVgNLQPGSKAAVTLKYVQ 131
Cdd:smart00609  80 KEVAQKQYEKAVSQGKTAGLVRASGRSMEQFTVSV-NVAPGSKVTFELTYEE 130
VIT pfam08487
Vault protein inter-alpha-trypsin domain; Inter-alpha-trypsin inhibitors (ITIs) consist of one ...
 17-129 8.24e-41

Vault protein inter-alpha-trypsin domain; Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilization and tumour metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.


Pssm-ID: 462492 [Multi-domain]  Cd Length: 111  Bit Score: 136.46  E-value: 8.24e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119587977   17 LKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIVAELQDKMKARTNYEKAISQGHQ 96
Cdd:pfam08487   1 LKSVSVDATITGRIARTTVTQTFVNPSNEALEAVYVFPLPEGAAVSGFTMTIGGKVIVGEVKEKEEAKKEYEEAVARGKT 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 119587977   97 AFLLEgdSSSRDVFSCNVGNLQPGSKAAVTLKY 129
Cdd:pfam08487  81 AGLLE--QDTPDVFTTSVGNIPPGEKVTVELTY 111
VIT_2 pfam13757
Vault protein inter-alpha-trypsin domain; Inter-alpha-trypsin inhibitors (ITIs) consist of one ...
 6-80 1.17e-14

Vault protein inter-alpha-trypsin domain; Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilization and tumour metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.


Pssm-ID: 404621  Cd Length: 78  Bit Score: 67.49  E-value: 1.17e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119587977    6 GLLTLH-REPVPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIVAELQDK 80
Cdd:pfam13757   2 GLLNWStRTPLPLKASRVSACVNGYSLGVTASLTYYNPQPYPVEGVFVYPLDEGTTVVGFEAEIAGRVISVQLKER 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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