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Conserved domains on  [gi|119582811|gb|EAW62407|]
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MEGF10 protein, isoform CRA_b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 432-477 4.64e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.87  E-value: 4.64e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 119582811   432 CDC----SHADGCHPTTGHCRCLPGWSGVHCDsVCAEGRWGPNCSLPCYC 477
Cdd:pfam00053    1 CDCnphgSLSDTCDPETGQCLCKPGVTGRHCD-RCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
258-300 2.39e-03

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 2.39e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 119582811    258 CPCHLENTHS--CHPMSGECACKPGWSGLYCNEtCSPGFYGEACQ 300
Cdd:smart00180    1 CDCDPGGSASgtCDPDTGQCECKPNVTGRRCDR-CAPGYYGDGPP 44
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 649-694 5.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 35.79  E-value: 5.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 119582811   649 CQCQN----GADCDHISGQCTCRTGFMGRHCEQkCPSGTYGYGCRQICDC 694
Cdd:pfam00053    1 CDCNPhgslSDTCDPETGQCLCKPGVTGRHCDR-CKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 432-477 4.64e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.87  E-value: 4.64e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 119582811   432 CDC----SHADGCHPTTGHCRCLPGWSGVHCDsVCAEGRWGPNCSLPCYC 477
Cdd:pfam00053    1 CDCnphgSLSDTCDPETGQCLCKPGVTGRHCD-RCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
258-300 2.39e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 2.39e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 119582811    258 CPCHLENTHS--CHPMSGECACKPGWSGLYCNEtCSPGFYGEACQ 300
Cdd:smart00180    1 CDCDPGGSASgtCDPDTGQCECKPNVTGRRCDR-CAPGYYGDGPP 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 649-694 5.45e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.79  E-value: 5.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 119582811   649 CQCQN----GADCDHISGQCTCRTGFMGRHCEQkCPSGTYGYGCRQICDC 694
Cdd:pfam00053    1 CDCNPhgslSDTCDPETGQCLCKPGVTGRHCDR-CKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 432-477 4.64e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.87  E-value: 4.64e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 119582811   432 CDC----SHADGCHPTTGHCRCLPGWSGVHCDsVCAEGRWGPNCSLPCYC 477
Cdd:pfam00053    1 CDCnphgSLSDTCDPETGQCLCKPGVTGRHCD-RCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
258-300 2.39e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 2.39e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 119582811    258 CPCHLENTHS--CHPMSGECACKPGWSGLYCNEtCSPGFYGEACQ 300
Cdd:smart00180    1 CDCDPGGSASgtCDPDTGQCECKPNVTGRRCDR-CAPGYYGDGPP 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 649-694 5.45e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.79  E-value: 5.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 119582811   649 CQCQN----GADCDHISGQCTCRTGFMGRHCEQkCPSGTYGYGCRQICDC 694
Cdd:pfam00053    1 CDCNPhgslSDTCDPETGQCLCKPGVTGRHCDR-CKPGYYGLPSDPPQGC 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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