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Conserved domains on  [gi|119581905|gb|EAW61501|]
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slit homolog 3 (Drosophila), isoform CRA_c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 863-989 1.07e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.07e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   863 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 940
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 119581905   941 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 989
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
263-575 9.72e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 9.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  263 LTGNQLETVHGRVFRGLSGLKTLMLRSNligcvsnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfnc 342
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL------- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  343 nchlawlgkwlrkrrivSGNPrcqkpffLKEIPiqdVAIQDFTcdgneesscQLsprcpeqctcmeTVVRCSNKGLRALP 422
Cdd:COG4886   144 -----------------SNNQ-------LTDLP---EPLGNLT---------NL------------KSLDLSNNQLTDLP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  423 R---GMPKdVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRS 499
Cdd:COG4886   176 EelgNLTN-LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTN 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119581905  500 LRVLTLHGNDISSVPEGSfnDLTSLSHLALGTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 575
Cdd:COG4886   252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
12-341 3.09e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 3.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   12 DISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFdglvslqllllnankinclrvntfqDLQNLNLLSLYDNKLQ 91
Cdd:COG4886   119 DLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-------------------------NLTNLKSLDLSNNQLT 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   92 TISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrcsgsedyrsrfs 171
Cdd:COG4886   173 DLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL-------------------------- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  172 secfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVRE 249
Cdd:COG4886   208 -----------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPP 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  250 GAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVS 329
Cdd:COG4886   268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                         330
                  ....*....|..
gi 119581905  330 LSTINLLSNPFN 341
Cdd:COG4886   346 LLALLTLLLLLN 357
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 749-785 3.13e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 3.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 119581905  749 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 785
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 673-706 9.70e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 9.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 119581905  673 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 706
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 798-828 5.94e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 5.94e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119581905   798 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 828
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 631-669 7.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 119581905  631 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 669
Cdd:cd00054     2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 710-747 7.48e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 119581905  710 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 747
Cdd:cd00054     2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1141-1196 5.44e-04

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 40.08  E-value: 5.44e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 119581905   1141 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1196
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1047-1075 5.00e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.00e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 119581905  1047 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1075
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 863-989 1.07e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.07e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   863 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 940
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 119581905   941 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 989
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
856-989 2.80e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 2.80e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905    856 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKG 932
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 119581905    933 TPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRINNE 989
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP-----GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 834-987 2.92e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 2.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  834 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 909
Cdd:cd00110     1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119581905  910 DGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRIN 987
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP-----GFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
263-575 9.72e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 9.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  263 LTGNQLETVHGRVFRGLSGLKTLMLRSNligcvsnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfnc 342
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL------- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  343 nchlawlgkwlrkrrivSGNPrcqkpffLKEIPiqdVAIQDFTcdgneesscQLsprcpeqctcmeTVVRCSNKGLRALP 422
Cdd:COG4886   144 -----------------SNNQ-------LTDLP---EPLGNLT---------NL------------KSLDLSNNQLTDLP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  423 R---GMPKdVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRS 499
Cdd:COG4886   176 EelgNLTN-LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTN 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119581905  500 LRVLTLHGNDISSVPEGSfnDLTSLSHLALGTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 575
Cdd:COG4886   252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
12-341 3.09e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 3.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   12 DISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFdglvslqllllnankinclrvntfqDLQNLNLLSLYDNKLQ 91
Cdd:COG4886   119 DLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-------------------------NLTNLKSLDLSNNQLT 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   92 TISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrcsgsedyrsrfs 171
Cdd:COG4886   173 DLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL-------------------------- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  172 secfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVRE 249
Cdd:COG4886   208 -----------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPP 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  250 GAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVS 329
Cdd:COG4886   268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                         330
                  ....*....|..
gi 119581905  330 LSTINLLSNPFN 341
Cdd:COG4886   346 LLALLTLLLLLN 357
LRR_8 pfam13855
Leucine rich repeat;
450-510 4.39e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 4.39e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119581905   450 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 510
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
232-292 2.84e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 2.84e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119581905   232 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLI 292
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 311-389 1.90e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.96  E-value: 1.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   311 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 387
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 119581905   388 GN 389
Cdd:TIGR00864   82 EE 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 409-535 7.49e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 7.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  409 TVVRCSNKGLRALPR-GMPKDVTELYLEGNHLTAVPrELSALRHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLR 487
Cdd:cd21340     5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  488 CIpvhafNGL---------------------------------RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPL 534
Cdd:cd21340    82 VV-----EGLenltnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154


                  .
gi 119581905  535 H 535
Cdd:cd21340   155 S 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
197-465 2.54e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  197 KLVRIPSHLPEYVTDLRLNDNEVsvleatgifKKLP-----NLRKINLSNNKIKEVREGAFDgaaSVQELMLTGNQLETV 271
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  272 HGRVfrgLSGLKTLMLRSNLIGCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 351
Cdd:PRK15370  257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  352 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgneesscqlsprCPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 431
Cdd:PRK15370  322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                         250       260       270
                  ....*....|....*....|....*....|....
gi 119581905  432 LYLEGNHLTAVPRELSALrhLTLIDLSNNSISML 465
Cdd:PRK15370  372 LDVSRNALTNLPENLPAA--LQIMQASRNNLVRL 403
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 749-785 3.13e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 3.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 119581905  749 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 785
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
532-581 4.43e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 4.43e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 119581905    532 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 581
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
EGF_CA smart00179
Calcium-binding EGF-like domain;
749-785 5.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 5.41e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 119581905    749 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFS-GPFCE 785
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 673-706 9.70e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 9.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 119581905  673 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 706
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 85-148 1.85e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 1.85e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119581905    85 LYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET---SGARCSSPRRLANK 148
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 675-704 5.33e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 5.33e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 119581905   675 CEDNDCENNATCVDGINNYVCICPPNYTGE 704
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 798-828 5.94e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 5.94e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119581905   798 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 828
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 753-783 6.49e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 6.49e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119581905   753 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 783
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 631-669 7.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 119581905  631 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 669
Cdd:cd00054     2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 710-747 7.48e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 119581905  710 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 747
Cdd:cd00054     2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-341 2.10e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   12 DISKNQISDIAPDAFQGLKSLTSLVLYGNKIT-EIAKGLFDglvslqllllnankinclrvntfqdLQNLNLLSLYDNKL 90
Cdd:PLN00113  242 DLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-------------------------LQKLISLDLSDNSL 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   91 QTISKGLFAPLQSIQTLHLAQNPFVCdchlkwladylqdnpiETSGARCSSPRRlankRISQIKSKKFRCSGSEDYRSRf 170
Cdd:PLN00113  297 SGEIPELVIQLQNLEILHLFSNNFTG----------------KIPVALTSLPRL----QVLQLWSNKFSGEIPKNLGKH- 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  171 SSECFMDLvcpEKCRCEGTIVD--CSNQKLVR-------IPSHLPEYVTD------LRLNDNEVSVlEATGIFKKLPNLR 235
Cdd:PLN00113  356 NNLTVLDL---STNNLTGEIPEglCSSGNLFKlilfsnsLEGEIPKSLGAcrslrrVRLQDNSFSG-ELPSEFTKLPLVY 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  236 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGlSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNR 315
Cdd:PLN00113  432 FLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK 510

                         330       340
                  ....*....|....*....|....*.
gi 119581905  316 ITTITPGAFTTLVSLSTINLLSNPFN 341
Cdd:PLN00113  511 LSGEIPDELSSCKKLVSLDLSHNQLS 536
EGF_CA smart00179
Calcium-binding EGF-like domain;
673-702 3.10e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 3.10e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 119581905    673 DDCE-DNDCENNATCVDGINNYVCICPPNYT 702
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1141-1196 5.44e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 40.08  E-value: 5.44e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 119581905   1141 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1196
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
LRRCT smart00082
Leucine rich repeat C-terminal domain;
112-142 6.62e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 6.62e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 119581905    112 NPFVCDCHLKWLADYLQDNPI--ETSGARCSSP 142
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
710-747 1.26e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.26e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 119581905    710 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYS-GKLCE 747
Cdd:smart00179    2 IDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1047-1075 5.00e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.00e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 119581905  1047 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1075
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 634-667 5.85e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 5.85e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 119581905   634 CIQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQR 667
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
637-669 8.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 8.55e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 119581905    637 NPCQHGGTCHlsdSHKDGFSCSCPLGFE-GQRCE 669
Cdd:smart00179    9 NPCQNGGTCV---NTVGSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 863-989 1.07e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.07e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   863 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 940
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 119581905   941 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 989
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
856-989 2.80e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 2.80e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905    856 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKG 932
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 119581905    933 TPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRINNE 989
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP-----GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 834-987 2.92e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 2.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  834 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 909
Cdd:cd00110     1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119581905  910 DGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRIN 987
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP-----GFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
263-575 9.72e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 9.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  263 LTGNQLETVHGRVFRGLSGLKTLMLRSNligcvsnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfnc 342
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL------- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  343 nchlawlgkwlrkrrivSGNPrcqkpffLKEIPiqdVAIQDFTcdgneesscQLsprcpeqctcmeTVVRCSNKGLRALP 422
Cdd:COG4886   144 -----------------SNNQ-------LTDLP---EPLGNLT---------NL------------KSLDLSNNQLTDLP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  423 R---GMPKdVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRS 499
Cdd:COG4886   176 EelgNLTN-LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTN 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119581905  500 LRVLTLHGNDISSVPEGSfnDLTSLSHLALGTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 575
Cdd:COG4886   252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
210-512 9.99e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 9.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  210 TDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKikevregAFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRS 289
Cdd:COG4886    74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  290 NLIGCVSnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfncnchlawlgkwlrkrrivSGNPrcqkpf 369
Cdd:COG4886   146 NQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL------------------------SNNQ------ 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  370 fLKEIPiqdvaiqdftcdgneessCQLSprcpeqctcmetvvrcsnkGLRALprgmpkdvTELYLEGNHLTAVPRELSAL 449
Cdd:COG4886   194 -ITDLP------------------EPLG-------------------NLTNL--------EELDLSGNQLTDLPEPLANL 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119581905  450 RHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIPVHAfnGLRSLRVLTLHGNDISS 512
Cdd:COG4886   228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
308-534 2.03e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 2.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  308 LLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQkpfFLKEIPIQDVAIQDFTCD 387
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDL---LLSSLLLLLSLLLLLLLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  388 GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALprgmpKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTN 467
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119581905  468 yTFSNMSHLSTLILSYNRLRCIPvHAFNGLRSLRVLTLHGNDISSVPEgSFNDLTSLSHLALGTNPL 534
Cdd:COG4886   154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
189-340 1.22e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 1.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  189 TIVDCSNQKLVRIPSHLPE--YVTDLRLNDNEVSVLEATgiFKKLPNLRKINLSNNKIKEVREgAFDGAASVQELMLTGN 266
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119581905  267 QLETVHGrVFRGLSGLKTLMLRSNLIGCVSnDTFAGLSSVRLLSLYDNRITTITpgAFTTLVSLSTINLLSNPF 340
Cdd:COG4886   193 QITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
12-341 3.09e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 3.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   12 DISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFdglvslqllllnankinclrvntfqDLQNLNLLSLYDNKLQ 91
Cdd:COG4886   119 DLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-------------------------NLTNLKSLDLSNNQLT 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   92 TISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrcsgsedyrsrfs 171
Cdd:COG4886   173 DLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL-------------------------- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  172 secfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVRE 249
Cdd:COG4886   208 -----------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPP 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  250 GAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVS 329
Cdd:COG4886   268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                         330
                  ....*....|..
gi 119581905  330 LSTINLLSNPFN 341
Cdd:COG4886   346 LLALLTLLLLLN 357
Laminin_G_1 pfam00054
Laminin G domain;
861-992 6.19e-18

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 81.21  E-value: 6.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   861 VATDKDNGILLYKGDNDP---LALELYQGHVRLVYDsLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTP--- 934
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYD-LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARptg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 119581905   935 -KSLGKLQKQPAVGinsPLYLGGIPTSTglSALRQGTDRPlgGFHGCIHEVRINNELQD 992
Cdd:pfam00054   80 eSPLGATTDLDVDG---PLYVGGLPSLG--VKKRRLAISP--SFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-340 8.25e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 8.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905    8 NVFRDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYD 87
Cdd:COG4886    43 LSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   88 NKLQTISKGLfAPLQSIQTLHLAQNpfvcdchlkwladylqdnpietsgarcssprrlankRISQIKSkkfrcsgsedyr 167
Cdd:COG4886   123 NQLTDLPEEL-ANLTNLKELDLSNN------------------------------------QLTDLPE------------ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  168 srfssecfmdlvcpekcrcegTIVDCSNqklvripshlpeyVTDLRLNDNEVSVLEATgiFKKLPNLRKINLSNNKIKEV 247
Cdd:COG4886   154 ---------------------PLGNLTN-------------LKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITDL 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  248 REgAFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRSNLIGCVSNdtFAGLSSVRLLSLYDNRITTITPGAftTL 327
Cdd:COG4886   198 PE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NL 271

                         330
                  ....*....|...
gi 119581905  328 VSLSTINLLSNPF 340
Cdd:COG4886   272 TNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
450-510 4.39e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 4.39e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119581905   450 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 510
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
232-292 2.84e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 2.84e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119581905   232 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLI 292
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
257-316 5.05e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 5.05e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   257 SVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRI 316
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
474-534 7.26e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 7.26e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119581905   474 SHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 534
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
280-340 8.08e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 8.08e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119581905   280 SGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPF 340
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 311-389 1.90e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.96  E-value: 1.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   311 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 387
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 119581905   388 GN 389
Cdd:TIGR00864   82 EE 83
LRR_8 pfam13855
Leucine rich repeat;
209-268 9.68e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 9.68e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   209 VTDLRLNDNEVSVLEAtGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQL 268
Cdd:pfam13855    3 LRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
429-486 2.38e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 2.38e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 119581905   429 VTELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 486
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 409-535 7.49e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 7.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  409 TVVRCSNKGLRALPR-GMPKDVTELYLEGNHLTAVPrELSALRHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLR 487
Cdd:cd21340     5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  488 CIpvhafNGL---------------------------------RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPL 534
Cdd:cd21340    82 VV-----EGLenltnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154


                  .
gi 119581905  535 H 535
Cdd:cd21340   155 S 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
197-465 2.54e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  197 KLVRIPSHLPEYVTDLRLNDNEVsvleatgifKKLP-----NLRKINLSNNKIKEVREGAFDgaaSVQELMLTGNQLETV 271
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  272 HGRVfrgLSGLKTLMLRSNLIGCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 351
Cdd:PRK15370  257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  352 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgneesscqlsprCPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 431
Cdd:PRK15370  322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                         250       260       270
                  ....*....|....*....|....*....|....
gi 119581905  432 LYLEGNHLTAVPRELSALrhLTLIDLSNNSISML 465
Cdd:PRK15370  372 LDVSRNALTNLPENLPAA--LQIMQASRNNLVRL 403
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 505-590 4.19e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 61.25  E-value: 4.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   505 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK---AGYKEPGIARCSSPEPMADRLLLTTPTHRFQCk 581
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80


                   ....*....
gi 119581905   582 gpvDINIVA 590
Cdd:TIGR00864   81 ---DEEYVA 86
PLN03150 PLN03150
hypothetical protein; Provisional
 442-535 6.54e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.21  E-value: 6.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  442 VPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLR-CIPvHAFNGLRSLRVLTLHGNDISS-VPEgsfn 519
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIP-ESLGQLTSLRILNLNGNSLSGrVPA---- 508

                          90
                  ....*....|....*.
gi 119581905  520 dltslshlALGTNPLH 535
Cdd:PLN03150  509 --------ALGGRLLH 516
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
372-534 8.43e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 8.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  372 KEIPIQDVAIQDF-TCDGNEESSCQLS--------PRCPEQCTcmeTVVrCSNKGLRALPRGMPKDVTELYLEGNHLTAV 442
Cdd:PRK15370  160 KEAANREEAVQRMrDCLKNNKTELRLKilglttipACIPEQIT---TLI-LDNNELKSLPENLQGNIKTLYANSNQLTSI 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  443 PRELSALrhLTLIDLSNNSISMLTNYTfsnMSHLSTLILSYNRLRCIPVHAFNGLRSLRVltlHGNDISSVPEgsfNDLT 522
Cdd:PRK15370  236 PATLPDT--IQEMELSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRYLSV---YDNSIRTLPA---HLPS 304

                         170
                  ....*....|..
gi 119581905  523 SLSHLALGTNPL 534
Cdd:PRK15370  305 GITHLNVQSNSL 316
LRR_8 pfam13855
Leucine rich repeat;
31-114 2.63e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905    31 SLTSLVLYGNKITEIAKGlfdglvslqllllnankinclrvnTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLA 110
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDG------------------------AFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                   ....
gi 119581905   111 QNPF 114
Cdd:pfam13855   58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 215-534 4.72e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 4.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  215 NDNEVSVLEATG---------IFKKLPNLRKINLSNNKIK-EVREGAFDGAASVQELMLTGNQLEtvhGRVFRG-LSGLK 283
Cdd:PLN00113   67 NSSRVVSIDLSGknisgkissAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsIPNLE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  284 TLMLRSNLI-GCVSNDtFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNC----------NCHLAWLG-- 350
Cdd:PLN00113  144 TLDLSNNMLsGEIPND-IGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqiprelgqmkSLKWIYLGyn 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  351 -------------KWLRKRRIVSGNPRCQKP-----------FFLKE------IPIQDVAIQDF-TCDGNEESscqLSPR 399
Cdd:PLN00113  223 nlsgeipyeigglTSLNHLDLVYNNLTGPIPsslgnlknlqyLFLYQnklsgpIPPSIFSLQKLiSLDLSDNS---LSGE 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  400 CPE---QCTCMETVVRCSNK-------GLRALPRgmpkdVTELYLEGNHLTA-VPRELSALRHLTLIDLSNNSISMLTNY 468
Cdd:PLN00113  300 IPElviQLQNLEILHLFSNNftgkipvALTSLPR-----LQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTGEIPE 374

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119581905  469 TFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 534
Cdd:PLN00113  375 GLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 749-785 3.13e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 3.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 119581905  749 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 785
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
532-581 4.43e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 4.43e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 119581905    532 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 581
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
12-52 6.24e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 6.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 119581905    12 DISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDG 52
Cdd:pfam13855    7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
EGF_CA smart00179
Calcium-binding EGF-like domain;
749-785 5.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 5.41e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 119581905    749 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFS-GPFCE 785
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 430-514 6.58e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 6.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  430 TELYLE------GNHLTAVPRELSALRH-LTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIP--VHAFNGLRSL 500
Cdd:cd21340    93 EELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSL 170

                          90
                  ....*....|....
gi 119581905  501 RVLTLHGNDISSVP 514
Cdd:cd21340   171 RELDLTGNPVCKKP 184
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 673-706 9.70e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 9.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 119581905  673 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 706
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 85-148 1.85e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 1.85e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119581905    85 LYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET---SGARCSSPRRLANK 148
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 675-704 5.33e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 5.33e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 119581905   675 CEDNDCENNATCVDGINNYVCICPPNYTGE 704
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 798-828 5.94e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 5.94e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119581905   798 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 828
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 753-783 6.49e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 6.49e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119581905   753 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 783
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
LRRCT smart00082
Leucine rich repeat C-terminal domain;
338-387 6.96e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 6.96e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 119581905    338 NPFNCNCHLAWLGKWLRKRRIVSG--NPRCQKPFFLKEiPIQDVAIQDFTCD 387
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRG-PLLELLHSEFKCP 51
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 631-669 7.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 119581905  631 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 669
Cdd:cd00054     2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 710-747 7.48e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 7.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 119581905  710 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 747
Cdd:cd00054     2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 420-486 1.44e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 1.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  420 ALPRGMPK--DVTELYLEGNHLTAV-PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 486
Cdd:PLN00113  490 AVPRKLGSlsELMQLKLSENKLSGEiPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 839-986 1.66e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 43.14  E-value: 1.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   839 GKDSYVELASAKVRPQAN-ISLQVATDKDNG---ILLYKGDNDPLALELYQ-GHVRLVYDSLSSPPTTVYSVETVNDGQF 913
Cdd:pfam13385    2 GGSDYVTLPDALLPTSDFtVSAWVKPDSLPGwarAIISSSGGGGYSLGLDGdGRLRFAVNGGNGGWDTVTSGASVPLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119581905   914 HSVeLVTLN-QTLNLVVDkGTPKSLGKLQKQPAVGINSPLYLGGiptstglsalRQGTDRPlggFHGCIHEVRI 986
Cdd:pfam13385   82 THV-AVTYDgGTLRLYVN-GVLVGSSTLTGGPPPGTGGPLYIGR----------SPGGDDY---FNGLIDEVRI 140
LRRNT smart00013
Leucine rich repeat N-terminal domain;
400-431 1.67e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.99  E-value: 1.67e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 119581905    400 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 431
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-341 2.10e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   12 DISKNQISDIAPDAFQGLKSLTSLVLYGNKIT-EIAKGLFDglvslqllllnankinclrvntfqdLQNLNLLSLYDNKL 90
Cdd:PLN00113  242 DLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-------------------------LQKLISLDLSDNSL 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   91 QTISKGLFAPLQSIQTLHLAQNPFVCdchlkwladylqdnpiETSGARCSSPRRlankRISQIKSKKFRCSGSEDYRSRf 170
Cdd:PLN00113  297 SGEIPELVIQLQNLEILHLFSNNFTG----------------KIPVALTSLPRL----QVLQLWSNKFSGEIPKNLGKH- 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  171 SSECFMDLvcpEKCRCEGTIVD--CSNQKLVR-------IPSHLPEYVTD------LRLNDNEVSVlEATGIFKKLPNLR 235
Cdd:PLN00113  356 NNLTVLDL---STNNLTGEIPEglCSSGNLFKlilfsnsLEGEIPKSLGAcrslrrVRLQDNSFSG-ELPSEFTKLPLVY 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  236 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGlSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNR 315
Cdd:PLN00113  432 FLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK 510

                         330       340
                  ....*....|....*....|....*.
gi 119581905  316 ITTITPGAFTTLVSLSTINLLSNPFN 341
Cdd:PLN00113  511 LSGEIPDELSSCKKLVSLDLSHNQLS 536
EGF_CA smart00179
Calcium-binding EGF-like domain;
673-702 3.10e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 3.10e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 119581905    673 DDCE-DNDCENNATCVDGINNYVCICPPNYT 702
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 756-785 3.29e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 3.29e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 119581905  756 HKCRHGAQCVDTINGYTCTCPQGFSGPF-CE 785
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 210-340 3.89e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905  210 TDLRLNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVrEGaFDGAASVQELMLTGNQLE-----TVHGRVFRGLSG-LK 283
Cdd:cd21340    49 THLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLR 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 119581905  284 TLMLRSNLIGCVSNdtFAGLSSVRLLSLYDNRITTITP--GAFTTLVSLSTINLLSNPF 340
Cdd:cd21340   124 VLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 758-779 4.28e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.47  E-value: 4.28e-04
                           10        20
                   ....*....|....*....|..
gi 119581905   758 CRHGAQCVDTINGYTCTCPQGF 779
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1141-1196 5.44e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 40.08  E-value: 5.44e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 119581905   1141 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1196
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
LRRCT smart00082
Leucine rich repeat C-terminal domain;
112-142 6.62e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 6.62e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 119581905    112 NPFVCDCHLKWLADYLQDNPI--ETSGARCSSP 142
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
710-747 1.26e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.26e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 119581905    710 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYS-GKLCE 747
Cdd:smart00179    2 IDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRR smart00370
Leucine-rich repeats, outliers;
231-254 1.35e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 1.35e-03
                            10        20
                    ....*....|....*....|....
gi 119581905    231 LPNLRKINLSNNKIKEVREGAFDG 254
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
231-254 1.35e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 1.35e-03
                            10        20
                    ....*....|....*....|....
gi 119581905    231 LPNLRKINLSNNKIKEVREGAFDG 254
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRRNT smart00013
Leucine rich repeat N-terminal domain;
180-210 2.35e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.53  E-value: 2.35e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 119581905    180 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVT 210
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 400-426 3.14e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 3.14e-03
                           10        20
                   ....*....|....*....|....*..
gi 119581905   400 CPEQCTCMETVVRCSNKGLRALPRGMP 426
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
12-130 3.71e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 3.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   12 DISKNQISDIAPDAfqGLKSLTSLVLYGNKITEIA-KGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 90
Cdd:COG4886   256 DLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 119581905   91 QTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN 130
Cdd:COG4886   334 LVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR smart00370
Leucine-rich repeats, outliers;
497-520 3.85e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 3.85e-03
                            10        20
                    ....*....|....*....|....
gi 119581905    497 LRSLRVLTLHGNDISSVPEGSFND 520
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
497-520 3.85e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 3.85e-03
                            10        20
                    ....*....|....*....|....
gi 119581905    497 LRSLRVLTLHGNDISSVPEGSFND 520
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 676-704 3.93e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 3.93e-03
                          10        20
                  ....*....|....*....|....*....
gi 119581905  676 EDNDCENNATCVDGINNYVCICPPNYTGE 704
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
LRR_9 pfam14580
Leucine-rich repeat;
214-297 4.43e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 4.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   214 LNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGrvFRGLSGLKTLMLRSNLIG 293
Cdd:pfam14580   49 FSDNEIRKLDG---FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGD--LDPLASLKKLTFLSLLRN 123


                   ....
gi 119581905   294 CVSN 297
Cdd:pfam14580  124 PVTN 127
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 680-699 4.69e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 4.69e-03
                           10        20
                   ....*....|....*....|
gi 119581905   680 CENNATCVDGINNYVCICPP 699
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPP 20
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1047-1075 5.00e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.00e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 119581905  1047 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1075
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 12-131 5.05e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581905   12 DISKNQISD-----IApDAFQGLKSLTSLVLYGNKITE-----IAKGLfDGLVSLQLLLLNANKI---------NCLRVN 72
Cdd:COG5238   242 DLSNNQIGDegviaLA-EALKNNTTVETLYLSGNQIGAegaiaLAKAL-QGNTTLTSLDLSVNRIgdegaialaEGLQGN 319

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119581905   73 tfqdlQNLNLLSLYDNKLQTI-SKGLFAPLQ---SIQTLHLAQNPfVCDCHLKWLADYLQDNP 131
Cdd:COG5238   320 -----KTLHTLNLAYNGIGAQgAIALAKALQentTLHSLDLSDNQ-IGDEGAIALAKYLEGNT 376
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 746-781 5.10e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 35.65  E-value: 5.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 119581905   746 CETDNDDCVAHkcrhgAQCVDTINGYTCTCPQGFSG 781
Cdd:pfam12947    1 CSDNNGGCHPN-----ATCTNTGGSFTCTCNDGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 634-667 5.85e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 5.85e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 119581905   634 CIQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQR 667
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
637-669 8.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 8.55e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 119581905    637 NPCQHGGTCHlsdSHKDGFSCSCPLGFE-GQRCE 669
Cdd:smart00179    9 NPCQNGGTCV---NTVGSYRCECPPGYTdGRNCE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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