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Conserved domains on  [gi|119577919|gb|EAW57515|]
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cone-rod homeobox [Homo sapiens]

Protein Classification

homeodomain and TF_Otx domain-containing protein( domain architecture ID 11078768)

homeodomain and TF_Otx domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
40-93 1.00e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.00e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 119577919   40 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 93
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
TF_Otx super family cl04137
Otx1 transcription factor;
164-249 2.08e-15

Otx1 transcription factor;


The actual alignment was detected with superfamily member pfam03529:

Pssm-ID: 427350  Cd Length: 91  Bit Score: 70.32  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119577919  164 SPASESPLPEAQRAGLVA----SGPSLTSAPYAMTYAPASAFCSSPSAygSPSSYFSGLD--PYLSPMVPQLGGP-ALSP 236
Cdd:pfam03529   1 SPASISPLPDPLAPSSAScmqrSVSSTASASYPMSYGQASAYSQGYPA--GSSSYFGGVDcgSYLSPMHSQLHHPhQLSP 78

                          90
                  ....*....|...
gi 119577919  237 LSGPSVGPSLAQS 249
Cdd:pfam03529  79 MTASSMGGHLHQH 91
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
40-93 1.00e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.00e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 119577919   40 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 93
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 39-94 2.28e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.39  E-value: 2.28e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 119577919    39 QRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKC 94
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 40-94 6.67e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 6.67e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 119577919  40 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKC 94
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
TF_Otx pfam03529
Otx1 transcription factor;
164-249 2.08e-15

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 70.32  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119577919  164 SPASESPLPEAQRAGLVA----SGPSLTSAPYAMTYAPASAFCSSPSAygSPSSYFSGLD--PYLSPMVPQLGGP-ALSP 236
Cdd:pfam03529   1 SPASISPLPDPLAPSSAScmqrSVSSTASASYPMSYGQASAYSQGYPA--GSSSYFGGVDcgSYLSPMHSQLHHPhQLSP 78

                          90
                  ....*....|...
gi 119577919  237 LSGPSVGPSLAQS 249
Cdd:pfam03529  79 MTASSMGGHLHQH 91
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
37-93 2.76e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.61  E-value: 2.76e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 119577919  37 RKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 93
Cdd:COG5576   49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
40-93 1.00e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.00e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 119577919   40 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 93
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 39-94 2.28e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.39  E-value: 2.28e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 119577919    39 QRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKC 94
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 40-94 6.67e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 6.67e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 119577919  40 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKC 94
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
TF_Otx pfam03529
Otx1 transcription factor;
164-249 2.08e-15

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 70.32  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119577919  164 SPASESPLPEAQRAGLVA----SGPSLTSAPYAMTYAPASAFCSSPSAygSPSSYFSGLD--PYLSPMVPQLGGP-ALSP 236
Cdd:pfam03529   1 SPASISPLPDPLAPSSAScmqrSVSSTASASYPMSYGQASAYSQGYPA--GSSSYFGGVDcgSYLSPMHSQLHHPhQLSP 78

                          90
                  ....*....|...
gi 119577919  237 LSGPSVGPSLAQS 249
Cdd:pfam03529  79 MTASSMGGHLHQH 91
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
37-93 2.76e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.61  E-value: 2.76e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 119577919  37 RKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 93
Cdd:COG5576   49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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