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Conserved domains on  [gi|1195703378|ref|XP_021034315|]
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olfactory receptor 4P4 [Mus caroli]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 24-289 1.10e-159

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 445.89  E-value: 1.10e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  24 LCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTH 103
Cdd:cd15939     2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 104 LFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLL 183
Cdd:cd15939    82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 184 KLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTF 263
Cdd:cd15939   162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                         250       260
                  ....*....|....*....|....*.
gi 1195703378 264 PEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15939   242 PIDKVVAVFYTIITPMLNPLIYTLRN 267
 
Name Accession Description Interval E-value
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 24-289 1.10e-159

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 445.89  E-value: 1.10e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  24 LCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTH 103
Cdd:cd15939     2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 104 LFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLL 183
Cdd:cd15939    82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 184 KLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTF 263
Cdd:cd15939   162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                         250       260
                  ....*....|....*....|....*.
gi 1195703378 264 PEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15939   242 PIDKVVAVFYTIITPMLNPLIYTLRN 267
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 29-299 2.84e-34

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 126.08  E-value: 2.84e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGI 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 109 EIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLACS 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 189 N---THIIGLLVIANSGLIALVTFVVlmaSYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYI--RPATT 262
Cdd:pfam13853 161 DikvNNIYGLFVVTSTFGIDSLLIVL---SYGLILRTVlGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHN 237

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 263 FPE--DKVFALFYTIIAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:pfam13853 238 VPPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276
 
Name Accession Description Interval E-value
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 24-289 1.10e-159

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 445.89  E-value: 1.10e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  24 LCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTH 103
Cdd:cd15939     2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 104 LFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLL 183
Cdd:cd15939    82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 184 KLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTF 263
Cdd:cd15939   162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                         250       260
                  ....*....|....*....|....*.
gi 1195703378 264 PEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15939   242 PIDKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 23-289 1.48e-125

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 359.21  E-value: 1.48e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15226     1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15226    81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATT 262
Cdd:cd15226   161 IKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFST 240

                         250       260
                  ....*....|....*....|....*..
gi 1195703378 263 FPEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15226   241 FPVDKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 23-289 3.40e-112

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 325.59  E-value: 3.40e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd13954     1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd13954    81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd13954   161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTIlKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 TFP--EDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd13954   241 SYSsdLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 23-289 1.46e-110

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 321.38  E-value: 1.46e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15230     1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15230    81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15230   161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITIlRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 TFP--EDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15230   241 SYSldQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 23-296 4.53e-109

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 317.86  E-value: 4.53e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15225     1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15225    81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15225   161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTIlKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195703378 262 TF--PEDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15225   241 SYspETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 26-289 1.02e-106

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 311.58  E-value: 1.02e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15936     4 FLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKL 185
Cdd:cd15936    84 GGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 ACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTFPE 265
Cdd:cd15936   164 ACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPM 243

                         250       260
                  ....*....|....*....|....
gi 1195703378 266 DKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15936   244 DKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 23-289 3.18e-106

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 310.53  E-value: 3.18e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15940     1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15940    81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATT 262
Cdd:cd15940   161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTS 240

                         250       260
                  ....*....|....*....|....*..
gi 1195703378 263 FPEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15940   241 FSEDKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 23-289 5.80e-102

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 299.76  E-value: 5.80e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITC-THLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFT 101
Cdd:cd15935     1 LLLFVLVLACYAAILLGNLLIVVTVHAdPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 102 THLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYP 181
Cdd:cd15935    81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 182 LLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15935   161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                         250       260
                  ....*....|....*....|....*...
gi 1195703378 262 TFPEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15935   241 SSSVDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 10-299 6.04e-102

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 300.43  E-value: 6.04e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  10 FILLGLSQNKNTEILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKV 89
Cdd:cd15943     2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  90 ITYNNCMIQLFTTHLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGP 169
Cdd:cd15943    82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 170 NEIDHYFCDVYPLLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLF 248
Cdd:cd15943   162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAIlRIHSSEGRRKAFSTCASHLMAVTIF 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195703378 249 FAPALFIYIRPATTFPE--DKVFALFYTIIAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15943   242 YGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 23-289 3.07e-101

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 297.55  E-value: 3.07e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15938     1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15938    81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRtySAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATT 262
Cdd:cd15938   161 IKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIR--STEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST 238

                         250       260
                  ....*....|....*....|....*..
gi 1195703378 263 FPEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15938   239 FPVDKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 10-293 2.10e-96

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 286.14  E-value: 2.10e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  10 FILLGLSQNKNTEILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKV 89
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  90 ITYNNCMIQLFTTHLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGP 169
Cdd:cd15408    81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 170 NEIDHYFCDVYPLLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLF 248
Cdd:cd15408   161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATIlRMRSAEGRHKAFSTCASHLTAVTLF 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1195703378 249 FAPALFIYIRPATTFPE--DKVFALFYTIIAPMFNPLIYTLRNTEMK 293
Cdd:cd15408   241 YGSLAFMYLRPSSRYSLdlDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 23-289 2.48e-96

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 285.15  E-value: 2.48e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTIlRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 TFPED--KVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15912   241 SSSLDlnKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 22-296 1.75e-95

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 283.34  E-value: 1.75e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  22 EILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFT 101
Cdd:cd15235     1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 102 THLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYP 181
Cdd:cd15235    81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 182 LLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPA 260
Cdd:cd15235   161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVlKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195703378 261 TTFP--EDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15235   241 SSYSadKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 23-298 1.67e-94

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 281.12  E-value: 1.67e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15419     1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15419    81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRP-A 260
Cdd:cd15419   161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTIlRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgA 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 261 TTFPE-DKVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15419   241 VSSPEqSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 10-299 2.48e-94

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 281.08  E-value: 2.48e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  10 FILLGLSQNKNTEILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKV 89
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  90 ITYNNCMIQLFTTHLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGP 169
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 170 NEIDHYFCDVYPLLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLF 248
Cdd:cd15410   161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTIlRIRSAEGRQKAFSTCASHLTAITIF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195703378 249 FAPALFIYIRPATTFP--EDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15410   241 HGTILFMYCRPSSSYSldTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 23-296 7.53e-93

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 276.84  E-value: 7.53e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15231     1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15231    81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15231   161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTIlKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195703378 262 TFP--EDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15231   241 GYSldKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 23-289 8.87e-93

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 276.46  E-value: 8.87e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15237     1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15237    81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15237   161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATIlRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 TFPE--DKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15237   241 THSPdqDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 23-296 9.50e-93

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 276.40  E-value: 9.50e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15229     1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15229    81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15229   161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTIlRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195703378 262 T--FPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15229   241 AssSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 23-289 1.69e-92

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 275.52  E-value: 1.69e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15911     1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15911    81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15911   161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTIlRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 TFPED--KVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15911   241 NTSRDlnKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 23-289 3.04e-92

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 274.69  E-value: 3.04e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15937     1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15937    81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATT 262
Cdd:cd15937   161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240

                         250       260
                  ....*....|....*....|....*..
gi 1195703378 263 FPEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15937   241 FPMDKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 23-289 5.14e-92

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 274.33  E-value: 5.14e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15227     1 ILHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15227    81 IFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15227   161 LKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVlRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 TFPE--DKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15227   241 DSPSllDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 23-298 4.69e-91

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 272.21  E-value: 4.69e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15417     1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15417    81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15417   161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTIlKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 262 TF--PEDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15417   241 SHsqDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 29-296 5.40e-91

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 272.12  E-value: 5.40e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFC-----YIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTH 103
Cdd:cd15421     2 FLFSlilliFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 104 LFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLL 183
Cdd:cd15421    82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 184 KLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT- 261
Cdd:cd15421   162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVlRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSy 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 262 -TFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15421   242 hSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 23-298 8.00e-91

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 271.55  E-value: 8.00e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15416     1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15416    81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15416   161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAIlRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 262 TFPED--KVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15416   241 SYSMDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 26-298 1.19e-89

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 268.80  E-value: 1.19e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15411     4 FVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKL 185
Cdd:cd15411    84 ATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 ACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTFP 264
Cdd:cd15411   164 SCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTIlKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYS 243

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 265 E--DKVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15411   244 LgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 24-289 2.62e-88

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 264.86  E-value: 2.62e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  24 LCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTH 103
Cdd:cd15918     2 LLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 104 LFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLL 183
Cdd:cd15918    82 LFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 184 KLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATT 262
Cdd:cd15918   162 KLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVlRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSS 241

                         250       260
                  ....*....|....*....|....*....
gi 1195703378 263 FP--EDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15918   242 HSasKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 10-298 6.41e-88

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 264.68  E-value: 6.41e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  10 FILLGLSQNKNTEILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKV 89
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  90 ITYNNCMIQLFTTHLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGP 169
Cdd:cd15945    81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 170 NEIDHYFCDVYPLLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLF 248
Cdd:cd15945   161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVlKIRSAEGRFKAFSTCASHLTAVGLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195703378 249 FAPALFIYIRPATTFP--EDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15945   241 YGTLLFMYLRPSSSYSldTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 23-296 8.45e-88

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 263.80  E-value: 8.45e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15420     1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15420    81 LALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15420   161 LKLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAIlKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195703378 262 TFPE--DKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15420   241 SNSAeqEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 14-299 1.11e-87

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 264.23  E-value: 1.11e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  14 GLSQNKNTEILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYN 93
Cdd:cd15406     1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  94 NCMIQLFTTHLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEID 173
Cdd:cd15406    81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 174 HYFCDVYPLLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPA 252
Cdd:cd15406   161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSIlRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1195703378 253 LFIYIRPAT--TFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15406   241 IFMYLKPSSssSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 23-289 2.76e-87

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 262.16  E-value: 2.76e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15431     1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASqLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15431    81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVI-PVLTMPLHFCGPNVINHFFCEVQAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRP-A 260
Cdd:cd15431   160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVlRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPqS 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 261 TTFPE-DKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15431   240 KSSSDqDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 23-289 1.05e-86

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 260.65  E-value: 1.05e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSIlRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 --TFPEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15232   241 sySPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 26-289 2.20e-86

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 259.93  E-value: 2.20e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15915     4 FVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKL 185
Cdd:cd15915    84 GSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 ACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI--RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT-- 261
Cdd:cd15915   164 ACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSgd 243

                         250       260
                  ....*....|....*....|....*...
gi 1195703378 262 TFPEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15915   244 SLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 26-296 5.01e-86

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 259.26  E-value: 5.01e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15429     4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKL 185
Cdd:cd15429    84 GGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 ACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTFP 264
Cdd:cd15429   164 ACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAIlRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195703378 265 --EDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15429   244 alQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 26-298 3.80e-85

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 257.34  E-value: 3.80e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15415     4 FMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKL 185
Cdd:cd15415    84 VTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 ACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTFP 264
Cdd:cd15415   164 SCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAIlRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYS 243

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 265 --EDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15415   244 leQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 23-298 8.03e-85

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 256.48  E-value: 8.03e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15413     1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15413    81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15413   161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAIlRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 262 T--FPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15413   241 ShsLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 23-298 1.39e-84

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 255.80  E-value: 1.39e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15409     1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15409    81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15409   161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTIlKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 262 TFP--EDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15409   241 LYAldQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 26-289 1.19e-83

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 252.93  E-value: 1.19e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNV-LIMVSITCTHLiEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHL 104
Cdd:cd15947     4 FVVVLIFYLLTLLGNTaIILLSLLDPRL-HTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 105 FGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLK 184
Cdd:cd15947    83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 185 LACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTF 263
Cdd:cd15947   163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVlRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                         250       260
                  ....*....|....*....|....*...
gi 1195703378 264 PED--KVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15947   243 SQDqgKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 23-299 2.61e-83

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 252.73  E-value: 2.61e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15414     1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15414    81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15414   161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAIlRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195703378 262 TFP--EDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15414   241 SSSldLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRT 280
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 23-298 2.45e-82

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 250.01  E-value: 2.45e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15412     1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15412    81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15412   161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAIlRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 262 --TFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15412   241 eeSVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 26-296 3.87e-82

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 249.27  E-value: 3.87e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15228     4 FVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKL 185
Cdd:cd15228    84 GSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 ACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTFP 264
Cdd:cd15228   164 ACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISIlKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPV 243

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195703378 265 EDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15228   244 LVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 23-296 5.07e-82

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 249.29  E-value: 5.07e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAER-KVITYNNCMIQLFT 101
Cdd:cd15916     1 SLLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 102 THLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYP 181
Cdd:cd15916    81 FHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 182 LLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPA 260
Cdd:cd15916   161 LLKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAIlRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPG 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 261 TTFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15916   241 SKEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 10-299 1.97e-81

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 248.16  E-value: 1.97e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  10 FILLGLSQNKNTEILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKV 89
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  90 ITYNNCMIQLFTTHLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGP 169
Cdd:cd15944    81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 170 NEIDHYFCDVYPLLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLF 248
Cdd:cd15944   161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAIlRMRSAEGRRKAFSTCASHFTGVTLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1195703378 249 FAPALFIYIRPAT--TFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15944   241 YGTVIFMYLRPTSvySLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 23-298 6.02e-79

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 241.56  E-value: 6.02e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15407     1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15407    81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15407   161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITIlRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 262 --TFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15407   241 shSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 23-289 3.46e-78

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 239.20  E-value: 3.46e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15914     1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15914    81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15914   161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVlKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 TFPE--DKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15914   241 SYSLdyDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 23-296 3.80e-77

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 236.56  E-value: 3.80e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15424     1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15424    81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRP-- 259
Cdd:cd15424   161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVlQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPrs 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195703378 260 ATTFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15424   241 GSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 23-289 1.97e-75

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 232.17  E-value: 1.97e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15224     1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15224    81 LSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15224   161 LNLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVlRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKA 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 --TFPEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15224   241 isSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 23-289 2.09e-75

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 231.88  E-value: 2.09e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGN-VLIMVSITCTHLiEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFT 101
Cdd:cd15430     1 ILLFVLCLIMYLVILLGNgVLIIITILDSHL-HTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 102 THLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYP 181
Cdd:cd15430    80 SLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 182 LLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPA 260
Cdd:cd15430   160 VLKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTIlRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPK 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195703378 261 T--TFPEDKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15430   240 SknAQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 26-296 2.62e-75

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 232.08  E-value: 2.62e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15234     4 FGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKL 185
Cdd:cd15234    84 GGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 ACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTFP 264
Cdd:cd15234   164 ACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSIlRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195703378 265 EDK--VFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15234   244 SRKtaVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 26-296 2.64e-74

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 229.24  E-value: 2.64e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15942     4 FLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKL 185
Cdd:cd15942    84 GCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 ACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTFP 264
Cdd:cd15942   164 ACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAIlKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDP 243

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1195703378 265 EDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15942   244 LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 24-296 2.09e-73

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 227.04  E-value: 2.09e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  24 LCFVFFLFCYIAIWMGNVLIMVSITC-THLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLA-ERKVITYNNCMIQLFT 101
Cdd:cd15941     2 LFFLLFLLIYLLTVLGNLLILLTIGSdPHLHGLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 102 THLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYP 181
Cdd:cd15941    82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 182 LLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPA 260
Cdd:cd15941   162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVlRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 261 TTFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15941   242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 23-296 2.57e-73

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 226.98  E-value: 2.57e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15432     1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVlRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195703378 262 TFPED--KVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15432   241 NSSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 23-296 6.89e-73

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 225.76  E-value: 6.89e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15405     1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15405    81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15405   161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNIlHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195703378 262 TFP--EDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15405   241 VGSvnQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 26-296 7.30e-73

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 225.72  E-value: 7.30e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNV-LIMVSITCTHLiEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHL 104
Cdd:cd15434     4 SVVVLIFYLLTLVGNTtIILVSCLDSRL-HTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 105 FGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRC-NLIIMTCCTgGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLL 183
Cdd:cd15434    83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCwKLVAMSWLI-GFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 184 KLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYT-IRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATT 262
Cdd:cd15434   162 KLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAvLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNS 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 263 FPED--KVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15434   242 VSQDqgKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 23-289 3.04e-72

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 223.89  E-value: 3.04e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15946     1 SILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15946    81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15946   161 LKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAIlKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 TF-PE-DKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15946   241 NYsPErDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 22-299 6.00e-72

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 223.51  E-value: 6.00e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  22 EILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFT 101
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 102 THLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYP 181
Cdd:cd15418    81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 182 LLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPA 260
Cdd:cd15418   161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAIlRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195703378 261 T--TFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15418   241 SshTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 24-296 5.74e-70

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 218.51  E-value: 5.74e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  24 LCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTH 103
Cdd:cd15233     2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 104 LFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLL 183
Cdd:cd15233    82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 184 KLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATT 262
Cdd:cd15233   162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVlRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 263 FP--EDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15233   242 YSsdKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 23-289 6.82e-70

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 217.95  E-value: 6.82e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15913     1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15913    81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYT-IRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPAT 261
Cdd:cd15913   161 LALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAvLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 262 TFPED--KVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15913   241 GNSTGmqKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 23-296 9.08e-70

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 217.73  E-value: 9.08e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15428     1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15428    81 LSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRP-- 259
Cdd:cd15428   161 LKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVfGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPks 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1195703378 260 ATTFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15428   241 STSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 24-296 1.48e-67

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 212.34  E-value: 1.48e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  24 LCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTH 103
Cdd:cd15433     2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 104 LFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLL 183
Cdd:cd15433    82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 184 KLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATT 262
Cdd:cd15433   162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVlRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHR 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 263 FPED--KVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15433   242 YSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 24-296 5.47e-67

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 210.78  E-value: 5.47e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  24 LCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTH 103
Cdd:cd15236     2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 104 LFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLL 183
Cdd:cd15236    82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 184 KLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATT 262
Cdd:cd15236   162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATIlKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 263 FPEDK--VFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15236   242 NSSDKdiVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 29-296 9.18e-55

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 179.41  E-value: 9.18e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGI 108
Cdd:cd15223     7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 109 EIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLACS 188
Cdd:cd15223    87 ESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 189 NT---HIIGLLVIAnsgLIALVTFVVLMASYFFILYT-IRTYSAESRSKALSTCSSHLTVVVLFFAPALFIYI--RPATT 262
Cdd:cd15223   167 DTtinSIYGLAVAW---LIVGSDIILIFFSYALILRAvLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGKT 243

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 263 FPED--KVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15223   244 IPPDvhVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 27-292 1.96e-47

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 160.15  E-value: 1.96e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  27 VFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFG 106
Cdd:cd15917     5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 107 GIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLA 186
Cdd:cd15917    85 AMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 187 CSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYIRPATTFPE 265
Cdd:cd15917   165 CGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVlQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1195703378 266 DK----VFALFYTIIAPMFNPLIYTLRNTEM 292
Cdd:cd15917   245 PPhvhiLLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 29-292 4.41e-47

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 159.47  E-value: 4.41e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFC--YIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFG 106
Cdd:cd15952     5 FPFCavYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 107 GIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLA 186
Cdd:cd15952    85 GMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 187 CSNTH---IIGLLVIansgLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYI--RPA 260
Cdd:cd15952   165 CASIRiniIYGLFAI----SVLVLDVILIALSYVLILRAVfRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthRFG 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195703378 261 TTFPE--DKVFALFYTIIAPMFNPLIYTLRNTEM 292
Cdd:cd15952   241 HNIPRyiHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 29-288 3.33e-46

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 157.19  E-value: 3.33e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFC--YIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFG 106
Cdd:cd15950     5 IPFCsmYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 107 GIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLA 186
Cdd:cd15950    85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 187 CSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALF-IYIRpatTFP 264
Cdd:cd15950   165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVlGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQ---RFG 241

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 265 ED------KVFALFYTIIAPMFNPLIYTLR 288
Cdd:cd15950   242 QGvpphtqVLLADLYLLVPPMLNPIIYGMR 271
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 29-291 3.60e-44

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 152.03  E-value: 3.60e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGI 108
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 109 EIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLACS 188
Cdd:cd15953    87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 189 NTHI-------IGLLVIA-NSGLIALvtfvvlmaSYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYI-- 257
Cdd:cd15953   167 DTTInriyglvVALLVVGlDLLLIAL--------SYALIIRAVlRLSSKKARQKALNTCTAHICVILMSYTPALFSFLth 238

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1195703378 258 RPATTFPE--DKVFALFYTIIAPMFNPLIYTLRNTE 291
Cdd:cd15953   239 RFGQGIAPhiHIILANLYLLVPPMLNPIIYGVKTKE 274
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 26-291 2.12e-43

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 149.96  E-value: 2.12e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15222     4 SIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKL 185
Cdd:cd15222    84 SFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 ACSNTH---IIGLLVIAnsgLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAP--ALFIYIRP 259
Cdd:cd15222   164 ACSDTRvnsIYGLFVVL---STMGLDSLLILLSYVLILKTVlGIASREERLKALNTCVSHICAVLIFYVPmiGLSMVHRF 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1195703378 260 ATTFPE--DKVFALFYTIIAPMFNPLIYTLRNTE 291
Cdd:cd15222   241 GKHASPlvHVLMANVYLLVPPVLNPIIYSVKTKQ 274
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 29-288 6.27e-43

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 148.59  E-value: 6.27e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGI 108
Cdd:cd15221     7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 109 EIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLACS 188
Cdd:cd15221    87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 189 NTHI---IGLLViansGLIALVTFVVLMA-SYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYI--RPAT 261
Cdd:cd15221   167 DITVniwYGLTV----ALLTVGLDVVLIAvSYALILRAVfRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGR 242

                         250       260
                  ....*....|....*....|....*....
gi 1195703378 262 TFPEDK--VFALFYTIIAPMFNPLIYTLR 288
Cdd:cd15221   243 HIPRHVhiLLANLYVLVPPMLNPIVYGVK 271
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 29-289 4.82e-41

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 143.64  E-value: 4.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGI 108
Cdd:cd15951     7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 109 EIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLACS 188
Cdd:cd15951    87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 189 NTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYI--RPATTFPE 265
Cdd:cd15951   167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVfKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLthRFGHNVPP 246

                         250       260
                  ....*....|....*....|....*.
gi 1195703378 266 --DKVFALFYTIIAPMFNPLIYTLRN 289
Cdd:cd15951   247 hvHILIANVYLLVPPMLNPIIYGVRT 272
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 29-292 2.54e-38

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 136.53  E-value: 2.54e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGI 108
Cdd:cd15956     7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 109 EIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLACS 188
Cdd:cd15956    87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 189 NTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYI----RPATTF 263
Cdd:cd15956   167 ATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVlRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHSVPS 246

                         250       260
                  ....*....|....*....|....*....
gi 1195703378 264 PEDKVFALFYTIIAPMFNPLIYTLRNTEM 292
Cdd:cd15956   247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 8-293 2.23e-36

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 131.82  E-value: 2.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378   8 TVFILLGLSQNKNTEILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAER 87
Cdd:cd15949     2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  88 KVITYNNCMIQLFTTHLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFC 167
Cdd:cd15949    82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 168 GPNEIDHYFCDVYPLLKLACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYT-IRTYSAESRSKALSTCSSHLTVVV 246
Cdd:cd15949   162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVvQRLATSEARLKTFGTCVSHVCAIL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195703378 247 LFFAP----ALFIYIRPATTFPEDKVFALFYTIIAPMFNPLIYTLRNTEMK 293
Cdd:cd15949   242 AFYVPiavsSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 29-293 2.95e-35

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 128.48  E-value: 2.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGI 108
Cdd:cd15948     8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 109 EIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLACS 188
Cdd:cd15948    88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 189 NTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALF---IYIRPATTFP 264
Cdd:cd15948   168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVlSLASKEEQLKAFGTCGSHICAILVFYTPVVLsstMHRFARHVAP 247

                         250       260       270
                  ....*....|....*....|....*....|
gi 1195703378 265 EDKVF-ALFYTIIAPMFNPLIYTLRNTEMK 293
Cdd:cd15948   248 HVHILlANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 29-292 5.50e-35

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 128.02  E-value: 5.50e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGI 108
Cdd:cd15954     7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 109 EIFILTGMAYDRYVAICRPLHYTIIMSrhrcNLIIMTCCTGGFVHSASQL----LLTIFLPFCGPNEIDHYFCDVYPLLK 184
Cdd:cd15954    87 ESGVLMLMALDRYVAICYPLRYATILT----NPVITKAGLATFLRGVMLIipfpLLTKRLPYCRGNFIPHTYCDHMSVVK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 185 LACSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTY-SAESRSKALSTCSSHLTVVVLFFAPALFIY------- 256
Cdd:cd15954   163 LACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLsSKEARSKAFSTCTAHICAIVITYTPAFFTFfahrfgg 242

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1195703378 257 --IRPATTFpedkVFALFYTIIAPMFNPLIYTLRNTEM 292
Cdd:cd15954   243 hhITPHIHI----IMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 29-299 2.84e-34

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 126.08  E-value: 2.84e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGI 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 109 EIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLACS 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 189 N---THIIGLLVIANSGLIALVTFVVlmaSYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIYI--RPATT 262
Cdd:pfam13853 161 DikvNNIYGLFVVTSTFGIDSLLIVL---SYGLILRTVlGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHN 237

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 263 FPE--DKVFALFYTIIAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:pfam13853 238 VPPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 28-292 7.13e-29

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 111.78  E-value: 7.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  28 FFLFCYIAIwMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGG 107
Cdd:cd15955     7 FCIMFLLAV-LGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 108 IEIFILTGMAYDRYVAICRPLHYTIIMSRH-RCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLA 186
Cdd:cd15955    86 FESGILLAMALDRYVAICHPLRHSSILTPQvLLGIGVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 187 CSNTHIIGLLVIANSGLIALVTFVVLMASYFFILYTI-RTYSAESRSKALSTCSSHLTVVVLFFAPALFIY--------I 257
Cdd:cd15955   166 ADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFfahrfghhV 245

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1195703378 258 RPATTFpedkVFALFYTIIAPMFNPLIYTLRNTEM 292
Cdd:cd15955   246 APYVHI----LLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 39-285 4.31e-24

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 98.52  E-value: 4.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  39 GNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLA-ERKVITYNNCMIQLFTTHLFGGIEIFILTGMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 118 YDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSasqLLLTIFLPFCGPNEIDHYFCDVYPLLKLACSNTHIIGLLV 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLS---LPPLLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 198 iansgLIALVTFVVLMASYFFILYTIRTYSAESRS--------KALSTCSSHLTVVVLFFAPALFIYIRPATTFPEDKV- 268
Cdd:pfam00001 158 -----LGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSr 232

                         250       260
                  ....*....|....*....|....
gi 1195703378 269 -------FALFYTIIAPMFNPLIY 285
Cdd:pfam00001 233 lldkalsVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 26-289 4.03e-15

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 73.86  E-value: 4.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd00637     2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDvypllkl 185
Cdd:cd00637    82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPD------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 186 acsnTHIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSH------------LTVVVLFF---A 250
Cdd:cd00637   155 ----LTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLlcwL 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1195703378 251 PALFIYIRPATTFPEDKVFALFYTI------IAPMFNPLIYTLRN 289
Cdd:cd00637   231 PYFILLLLDVFGPDPSPLPRILYFLalllayLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 27-296 4.59e-11

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 61.81  E-value: 4.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  27 VFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFG 106
Cdd:cd14967     4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 107 GIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCgpnEIDHYFCDVYPllkla 186
Cdd:cd14967    84 TASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQP---SVVDCECEFTP----- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 187 cSNTHIIGLLVIAnsgliALVTFVVLMASYFFILYTIRTYsaesrSKALSTcsshLTVVVLFF----APALFIYIRPAtT 262
Cdd:cd14967   156 -NKIYVLVSSVIS-----FFIPLLIMIVLYARIFRVARRE-----LKAAKT----LAIIVGAFllcwLPFFIIYLVSA-F 219

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1195703378 263 FPEDKVFALFYTIIA------PMFNPLIYTLRNTEMKNAL 296
Cdd:cd14967   220 CPPDCVPPILYAVFFwlgylnSALNPIIYALFNRDFRRAF 259
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 27-296 7.10e-11

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 61.84  E-value: 7.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  27 VFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFG 106
Cdd:cd14969     5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 107 GIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGgfvhsasqLLLTIFlPFCGPN----EIDHYFCDVYPL 182
Cdd:cd14969    85 LVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYG--------LFWALP-PLFGWSsyvpEGGGTSCSVDWY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LKLACSNTHIIGLLVIANsgliaLVTFVVLMASYFFILYTIRTYSA-------ESRSKALSTCSSHLTVVVLFFAPALFI 255
Cdd:cd14969   156 SKDPNSLSYIVSLFVFCF-----FLPLAIIIFCYYKIYRTLRKMSKraarrknSAITKRTKKAEKKVAKMVLVMIVAFLI 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1195703378 256 YIRP-------ATTFPEDKVFALFYTIIA------PMFNPLIYTLRNTEMKNAL 296
Cdd:cd14969   231 AWTPyavvslyVSFGGESTIPPLLATIPAlfakssTIYNPIIYVFMNKQFRRAL 284
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
 38-144 8.93e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 46.25  E-value: 8.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  38 MGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGIEIFILTGMA 117
Cdd:cd15336    16 LGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAIS 95

                          90       100
                  ....*....|....*....|....*..
gi 1195703378 118 YDRYVAICRPLHYTIIMSRHRCNLIIM 144
Cdd:cd15336    96 LDRYLVITKPLASIRWVSKKRAMIIIL 122
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 27-151 4.82e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 44.19  E-value: 4.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  27 VFFLFCYIAIWMGNV-LIMVSITCTHLIEQPMYFFLNyLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd15074     5 IYLTVIGILSTLGNGtVLFVLYRRRSKLKPAELLTVN-LAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLF 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGF 151
Cdd:cd15074    84 GCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALF 129
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 23-144 5.07e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 44.11  E-value: 5.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIwMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15326     2 LLGLVLGAFILFAI-VGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIM 144
Cdd:cd15326    81 VLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALL 122
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 38-144 6.73e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 43.73  E-value: 6.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  38 MGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGIEIFILTGMA 117
Cdd:cd15325    16 LGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIIS 95

                          90       100
                  ....*....|....*....|....*..
gi 1195703378 118 YDRYVAICRPLHYTIIMSRHRCNLIIM 144
Cdd:cd15325    96 IDRYIGVSYPLRYPSIMTERRGLLALL 122
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
 38-148 1.61e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 42.61  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  38 MGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERK-VITYNNCMIQLFTTHLFGGIEIFILTGM 116
Cdd:cd15304    16 AGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLFSTASIMHLCAI 95

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1195703378 117 AYDRYVAICRPLHYTIIMSRHRCNLIIMTCCT 148
Cdd:cd15304    96 SLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWT 127
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
 23-295 3.36e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 41.33  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15063     1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVhsasqlllTIFLPFCGPNEIDHYFCDVYPL 182
Cdd:cd15063    81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFV--------ICFPPLVGWNDGKDGIMDYSGS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 --LKLACSNTHIIGLLVIANSGLIALVTFVVLmasyFFILYTIRTYSAEsrSKALSTCSSHLTVVVLFFAPALFIYIRPA 260
Cdd:cd15063   153 ssLPCTCELTNGRGYVIYSALGSFYIPMLVML----FFYFRIYRAARME--TKAAKTVAIIVGCFIFCWLPFFTVYLVRA 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195703378 261 ttFPEDKVFALFYTII------APMFNPLIYTLRNTEMKNA 295
Cdd:cd15063   227 --FCEDCIPPLLFSVFfwlgycNSALNPCIYALFSRDFRFA 265
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 94-296 3.71e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 41.47  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  94 NCMIQLFTThlfggIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFvhsasqllLTIFLPFCGPNEiD 173
Cdd:cd14968    75 ACLVLVLTQ-----SSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSF--------LVGLTPMFGWNN-G 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 174 HYFCDVYPLLKLACSNTHIIGL--LVIANSGLIALVTFVVLMASYFFILYTIRTysaESRSKALSTCSSH---------- 241
Cdd:cd14968   141 APLESGCGEGGIQCLFEEVIPMdyMVYFNFFACVLVPLLIMLVIYLRIFRVIRK---QLRQIESLLRSRRsrstlqkevk 217

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1195703378 242 ----LTVVVLFFAPA-LFIYIRPATTF--PEDKV--FALFYTII----APMFNPLIYTLRNTEMKNAL 296
Cdd:cd14968   218 aaksLAIILFLFALCwLPLHIINCITLfcPECKVpkILTYIAILlshaNSAVNPIVYAYRIRKFRQTF 285
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 95-146 1.21e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 39.84  E-value: 1.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1195703378  95 CMIQLFTTHLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTC 146
Cdd:cd15055    73 CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLC 124
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 30-296 1.29e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 39.51  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  30 LFCYIAIwMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGIE 109
Cdd:cd15327     9 IFILMAI-VGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTAS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 110 IFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLlltifLPFCGPNEIDHYFCDV-----YPLLK 184
Cdd:cd15327    88 ILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPL-----LGWKEPPPPDESICSIteepgYALFS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 185 LACSnthiigllviansgliALVTFVVLMASYFFILYTIRTYSAEsrSKALSTCSSHLTVVVLFFAPalFIYIRPATTF- 263
Cdd:cd15327   163 SLFS----------------FYLPLMVILVMYFRVYVVALKFSRE--KKAAKTLAIVVGVFILCWFP--FFFVLPLGSFf 222

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 264 ----PEDKVFALFYTI--IAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15327   223 palkPSEMVFKVIFWLgyFNSCVNPIIYPCSSKEFKRAF 261
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 34-145 1.53e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 39.74  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  34 IAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPklMTDLLAERKVITYNNCMIQLFTThlfggIEIFIL 113
Cdd:cd15058    12 LAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVP--LGATIVVTGKWQLGNFWCELWTS-----VDVLCV 84

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1195703378 114 TG-------MAYDRYVAICRPLHYTIIMSRHRCNLIIMT 145
Cdd:cd15058    85 TAsietlcvIAVDRYIAITRPLRYQVLLTKRRARVIVCV 123
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
 39-285 1.73e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 39.20  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  39 GNVLIMVSI-------TCTHlieqpmYFFLNyLSLSDLCYTSTVtPKLMTDLLAERKVITYNNCMIQLFTTHLFGGIEIF 111
Cdd:cd14970    17 GNSLVIYVIlryskmkTVTN------IYILN-LAVADELFLLGL-PFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 112 ILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTcctggfVHSASQLLLTIFLPFCG--PNEIDHYFCdvypLLKLACSN 189
Cdd:cd14970    89 CLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLC------VWALSLVLGLPVIIFARtlQEEGGTISC----NLQWPDPP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 190 THIIGLLVIANSGLIALVTFVVLMASYFFILYTIRTYSAESRSKALSTCSSH-------LTVVVLFFAPALFIYI----R 258
Cdd:cd14970   159 DYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKRRARrkvtrlvLVVVAVFVVCWLPFHVfqivR 238

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1195703378 259 PATTFPEDKVF-ALFYTIIAPMF-----NPLIY 285
Cdd:cd14970   239 LLIDPPETLTVvGVFLFCIALSYansclNPILY 271
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 29-143 2.03e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 39.01  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  29 FLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQlfttHLFGGI 108
Cdd:cd15351     7 FLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQ----HMDNVI 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1195703378 109 EIFILTGM----------AYDRYVAICRPLHYTIIMSRHRCNLII 143
Cdd:cd15351    83 DTMICSSVvsslsflgaiAVDRYITIFYALRYHSIMTLQRAVNAI 127
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
 23-128 2.60e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 38.68  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIeQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTT 102
Cdd:cd15085     2 ILSFLMFLNATFSIFNNVLVIAVTLKNPQLR-NPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAV 80

                          90       100
                  ....*....|....*....|....*.
gi 1195703378 103 HLFGGIEIFILTGMAYDRYVAICRPL 128
Cdd:cd15085    81 NYFGIVSLWSLTLLAYERYNVVCKPM 106
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 26-296 2.81e-03

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 38.81  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  26 FVFFLFCYIAIWMgNVLIMVSITCTHLIEQPMYFFLNYLSLSDlCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLF 105
Cdd:cd14972     3 VVAIVLGVFIVVE-NSLVLAAIIKNRRLHKPMYILIANLAAAD-LLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 106 GGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSAsqllltifLPFCGPN--EIDHYFC-DVYPL 182
Cdd:cd14972    81 LLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNcvLCDQESCsPLGPG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 183 LklacSNTHIIGLLVIAnsgLIALVTFVVLMASYFFILYT----IRTYSAESRSKALST-CSSHLTVVVLF------FAP 251
Cdd:cd14972   153 L----PKSYLVLILVFF---FIALVIIVFLYVRIFWCLWRhanaIAARQEAAVPAQPSTsRKLAKTVVIVLgvflvcWLP 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1195703378 252 aLFIYIRPATTFPEDK------VFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd14972   226 -LLILLVLDVLCPSVCdiqavfYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
 31-296 2.91e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 38.76  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  31 FCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGIEI 110
Cdd:cd15323     9 FLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 111 FILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCctggfvhsasqLLLTIFLPFcgPNEIDHY---FCDVYPLLKLAC 187
Cdd:cd15323    89 VHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTV-----------WLISAVISF--PPLISMYrdpEGDVYPQCKLND 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 188 SNTHIIgllviaNSGLIALVTFVVLMasyffILYTIRTYS-AESRSKALSTCsshLTVVV---------LFFAPALFIYI 257
Cdd:cd15323   156 ETWYIL------SSCIGSFFAPCLIM-----ILVYIRIYRvAKAREKRFTFV---LAVVMgvfvvcwfpFFFSYSLYGIC 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1195703378 258 RPATTFPEdKVFALFYTI--IAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15323   222 REACEVPE-PLFKFFFWIgyCNSSLNPVIYTIFNQDFRRSF 261
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 23-296 3.14e-03

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 38.39  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  23 ILCFVFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTP-KLMTDLLAERKVITYNNCMIQLFT 101
Cdd:cd15328     1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPlSLVHELSGRRWQLGRSLCQVWISF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 102 THLFGGIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTiflpfcgpneidhyFCDVYP 181
Cdd:cd15328    81 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFG--------------WGETYS 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 182 LLKLACSNTHIIGLLVIANSGLIALVTFVVLmasyfFILYTIRTySAESRSKALSTCSSHLTVVVL----FFAPALFIYI 257
Cdd:cd15328   147 EDSEECQVSQEPSYTVFSTFGAFYLPLCVVL-----FVYWKIYK-AAQKEKRAALMVGILIGVFVLcwipFFLTELISPL 220

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1195703378 258 RPATTFPEDKVFALFYTIIAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15328   221 CSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 39-224 5.36e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 38.00  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  39 GNVLIMVSITCTHLIeQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNN-----CMIQLFTTHLFGGIEIFIL 113
Cdd:cd14978    17 GNILNLVVLTRKSMR-SSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYfyayfLPYIYPLANTFQTASVWLT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378 114 TGMAYDRYVAICRPLHYTIIMSRHRCNLIIMTCCTGGFVHSASQLLLTIFLPFCGPNEIDHYFCDVYPLLKLACSNTHIi 193
Cdd:cd14978    96 VALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNETYLLKY- 174

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1195703378 194 glLVIANSGLIALVTFVVLMASYFFILYTIR 224
Cdd:cd14978   175 --YFWLYAIFVVLLPFILLLILNILLIRALR 203
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 27-145 5.93e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 37.81  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  27 VFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFG 106
Cdd:cd15012     4 ILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSY 83

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1195703378 107 GIEIFILTGMAYDRYVAICRPLHYTIIMSRHRCNLIIMT 145
Cdd:cd15012    84 TASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVT 122
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
 31-143 6.91e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 37.58  E-value: 6.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  31 FCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGIEI 110
Cdd:cd15959     9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASI 88

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1195703378 111 FILTGMAYDRYVAICRPLHYTIIMSRHRCNLII 143
Cdd:cd15959    89 ETLCAIAVDRYLAITNPLRYEALVTKRRARTAV 121
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 60-159 9.03e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 37.21  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  60 FLNYLSLSDLCYTSTVTPKLMTDLLAERKVITYNNCMIQLFTTHLFGGIEIFILTGMAYDRYVAICRPLHytiimsRHRC 139
Cdd:cd15123    38 FITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPLE------LQTS 111

                          90       100
                  ....*....|....*....|
gi 1195703378 140 NLIIMTCCTGGFVHSASQLL 159
Cdd:cd15123   112 DAVLKTCCKAGCVWIVSMLF 131
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
 27-146 9.37e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 37.17  E-value: 9.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195703378  27 VFFLFCYIAIWMGNVLIMVSITCTHLIEQPMYFFLNYLSLSDLCYTSTvTPKLMTDLLAERKVITYNNCMIQLFTTHLFG 106
Cdd:cd15079     5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIK-MPIFIYNSFYEGWALGPLGCQIYAFLGSLSG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1195703378 107 GIEIFILTGMAYDRYVAICRPLHYTiIMSRHRCNLIIMTC 146
Cdd:cd15079    84 IGSIWTNAAIAYDRYNVIVKPLNGN-PLTRGKALLLILFI 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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