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Conserved domains on  [gi|119569421|gb|EAW49036|]
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WD repeat domain 36, isoform CRA_b [Homo sapiens]

Protein Classification

WD40 and Utp21 domain-containing protein( domain architecture ID 13235296)

WD40 and Utp21 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 689-891 1.79e-68

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


:

Pssm-ID: 461219  Cd Length: 209  Bit Score: 226.26  E-value: 1.79e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  689 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAP------EQNNDPQQSKVVNL 762
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  763 GVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLspDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLA 842
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119569421  843 LFLKLHLKMLPSEPV--LLEEITNLSSQVEENWTHLQSLFNQSMCILNYLK 891
Cdd:pfam04192 159 VFLKLHGDVIHSNEEeeLREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 COG2319
WD40 repeat [General function prediction only];
164-636 4.05e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 4.05e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 164 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 243
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 244 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 323
Cdd:COG2319   89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 324 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 403
Cdd:COG2319  163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 404 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 483
Cdd:COG2319  191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 484 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 560
Cdd:COG2319  247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119569421 561 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 636
Cdd:COG2319  325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-217 3.25e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 3.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  93 ARNKEIVHTFKGHKAEIHFLQPFGD--HIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 169
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119569421 170 QGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVII 217
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 689-891 1.79e-68

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 226.26  E-value: 1.79e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  689 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAP------EQNNDPQQSKVVNL 762
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  763 GVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLspDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLA 842
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119569421  843 LFLKLHLKMLPSEPV--LLEEITNLSSQVEENWTHLQSLFNQSMCILNYLK 891
Cdd:pfam04192 159 VFLKLHGDVIHSNEEeeLREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 COG2319
WD40 repeat [General function prediction only];
164-636 4.05e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 4.05e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 164 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 243
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 244 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 323
Cdd:COG2319   89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 324 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 403
Cdd:COG2319  163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 404 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 483
Cdd:COG2319  191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 484 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 560
Cdd:COG2319  247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119569421 561 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 636
Cdd:COG2319  325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 276-594 6.55e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 6.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 276 HSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIRYYGqNGQQILSASQDGTLQSFSTVH 355
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 356 EKFNKSL-GHglinKKRVkrkglqntMSVRLPPITKFAAEeareSDWDGIIAChqgklscstWNyqksTIGAYFLKPKEL 434
Cdd:cd00200   83 GECVRTLtGH----TSYV--------SSVAFSPDGRILSS----SSRDKTIKV---------WD----VETGKCLTTLRG 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 435 KKDDITAtaVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKN 514
Cdd:cd00200  134 HTDWVNS--VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 515 KILIHSvsLSSSPNI---MLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIR 591
Cdd:cd00200  209 GKCLGT--LRGHENGvnsVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                 ...
gi 119569421 592 TWD 594
Cdd:cd00200  287 IWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-594 1.09e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 1.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 119569421   555 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 594
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
556-594 2.48e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 2.48e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 119569421  556 RKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 594
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-217 3.25e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 3.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  93 ARNKEIVHTFKGHKAEIHFLQPFGD--HIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 169
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119569421 170 QGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVII 217
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 517-625 6.91e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 45.80  E-value: 6.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  517 LIHSVSLSSSPNIMLLHRDSGILGLA-LDDFSISVLDIETRKIVrefsghqGQIN------DMAFSPDGRWLISAAMDCS 589
Cdd:TIGR03866  75 VLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL-------AQIDvgvepeGMAVSPDGKIVVNTSETTN 147

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 119569421  590 IRTW-DLPSGCLIDCFLLDSAPLNVSMSPTGDFLATS 625
Cdd:TIGR03866 148 MAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-132 3.93e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 119569421    95 NKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWH 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 689-891 1.79e-68

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 226.26  E-value: 1.79e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  689 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAP------EQNNDPQQSKVVNL 762
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  763 GVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLspDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLA 842
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119569421  843 LFLKLHLKMLPSEPV--LLEEITNLSSQVEENWTHLQSLFNQSMCILNYLK 891
Cdd:pfam04192 159 VFLKLHGDVIHSNEEeeLREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 COG2319
WD40 repeat [General function prediction only];
164-636 4.05e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 4.05e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 164 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 243
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 244 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 323
Cdd:COG2319   89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 324 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 403
Cdd:COG2319  163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 404 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 483
Cdd:COG2319  191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 484 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 560
Cdd:COG2319  247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119569421 561 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 636
Cdd:COG2319  325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
164-597 2.59e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 2.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 164 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 243
Cdd:COG2319   51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 244 DGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifDGPTGegRLLRFRMGHS 323
Cdd:COG2319  131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATG--KLLRTLTGHT 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 324 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 403
Cdd:COG2319  205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL---------------WD- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 404 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGkdqAHK 483
Cdd:COG2319  233 ---LATGKL------------------LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHS 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 484 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIML-LHRDSGILGLALDDFSISVLDIETRKIVR 560
Cdd:COG2319  289 GGVNSVAFspDG--KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVaFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 119569421 561 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPS 597
Cdd:COG2319  367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 276-594 6.55e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 6.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 276 HSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIRYYGqNGQQILSASQDGTLQSFSTVH 355
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 356 EKFNKSL-GHglinKKRVkrkglqntMSVRLPPITKFAAEeareSDWDGIIAChqgklscstWNyqksTIGAYFLKPKEL 434
Cdd:cd00200   83 GECVRTLtGH----TSYV--------SSVAFSPDGRILSS----SSRDKTIKV---------WD----VETGKCLTTLRG 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 435 KKDDITAtaVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKN 514
Cdd:cd00200  134 HTDWVNS--VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 515 KILIHSvsLSSSPNI---MLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIR 591
Cdd:cd00200  209 GKCLGT--LRGHENGvnsVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                 ...
gi 119569421 592 TWD 594
Cdd:cd00200  287 IWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-364 6.59e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.58  E-value: 6.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  99 VHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFKISAILHpstyLNKILLGSEQGSLQL 175
Cdd:cd00200    2 RRTLKGHTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD----GTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 176 WNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHpVMAAGSPC 255
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 256 GHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDgptgEGRLLRFRMGHSAPLTNIRYyGQN 335
Cdd:cd00200  157 GTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVAF-SPD 230

                        250       260       270
                 ....*....|....*....|....*....|
gi 119569421 336 GQQILSASQDGTLQSFSTVHEKFNKSL-GH 364
Cdd:cd00200  231 GYLLASGSEDGTIRVWDLRTGECVQTLsGH 260
WD40 COG2319
WD40 repeat [General function prediction only];
3-349 4.34e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 4.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421   3 RASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFyVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMA--ADGRL 80
Cdd:COG2319   56 GDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAfsPDGKT 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  81 VFAAYGN----VFSAfaRNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSA 153
Cdd:COG2319  135 LASGSADgtvrLWDL--ATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVR--SV 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 154 ILHPStylNKILL-GSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVIIHNIKFNETLMKFRQD 232
Cdd:COG2319  211 AFSPD---GKLLAsGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 233 WGPITSISFRTDGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptge 312
Cdd:COG2319  288 SGGVNSVAFSPDGKLLASGSDD-GTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT---- 361

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 119569421 313 GRLLRFRMGHSAPLTNIRYyGQNGQQILSASQDGTLQ 349
Cdd:COG2319  362 GELLRTLTGHTGAVTSVAF-SPDGRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-348 4.31e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 4.31e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  71 ICCMA--ADGRLVFAAYGN----VFSAFarNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQL 142
Cdd:cd00200   12 VTCVAfsPDGKLLATGSGDgtikVWDLE--TGELLRTLKGHTGPVRDVAasADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 143 T-FDKSVFKISaiLHPSTYLnkILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVIIHNIK 221
Cdd:cd00200   90 TgHTSYVSSVA--FSPDGRI--LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 222 FNETLMKFRQDWGPITSISFRTDGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNAL 301
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDGTI 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 119569421 302 RIWifDGPTGEgRLLRFRmGHSAPLTNIRYYGqNGQQILSASQDGTL 348
Cdd:cd00200  244 RVW--DLRTGE-CVQTLS-GHTNSVTSLAWSP-DGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
31-304 2.71e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 2.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  31 VRFSALKRRFyVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMA--ADGRLVFAAYGN----VFSAfaRNKEIVHTFKG 104
Cdd:COG2319  126 VAFSPDGKTL-ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDgtvrLWDL--ATGKLLRTLTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 105 HKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEeyLQLTFDKSVFKISAI-LHPStylNKILL-GSEQGSLQLWNVKS 180
Cdd:COG2319  203 HTGAVRSVAfsPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVaFSPD---GRLLAsGSADGTVRLWDLAT 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 181 NKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVmAAGSPCGHIGL 260
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRL 356

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 119569421 261 WDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIW 304
Cdd:COG2319  357 WDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 442-636 1.65e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 442 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIH-- 519
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRtl 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 520 --------SVSLSSSPNIML---------------------------------LHRDSGILGLALDDFSISVLDIETRKI 558
Cdd:cd00200   90 tghtsyvsSVAFSPDGRILSsssrdktikvwdvetgkclttlrghtdwvnsvaFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119569421 559 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 636
Cdd:cd00200  170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsVAFSPDGYLLASGSEDG-TIRVWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 480-636 2.67e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 2.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 480 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILI-----HSVSLSSSpnimLLHRDSGILGLALDDFSISVLDIE 554
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrtlkgHTGPVRDV----AASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 555 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLgIY 633
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNsVAFSPDGTFVASSSQDGT-IK 160


                 ...
gi 119569421 634 LWS 636
Cdd:cd00200  161 LWD 163
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-304 6.53e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 6.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  94 RNKEIVHTFKGHKAEI---HFLQpfGDHIISVD-TDGILIIWHIysEEEYLQLTFD---KSVFKISaiLHPStylNKILL 166
Cdd:cd00200   81 ETGECVRTLTGHTSYVssvAFSP--DGRILSSSsRDKTIKVWDV--ETGKCLTTLRghtDWVNSVA--FSPD---GTFVA 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 167 GSEQ-GSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDG 245
Cdd:cd00200  152 SSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119569421 246 HpVMAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIW 304
Cdd:cd00200  232 Y-LLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-636 5.79e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 5.79e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119569421 559 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLgIYLWS 636
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRdVAASADGTYLASGSSDKT-IRLWD 79
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-594 1.09e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 1.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 119569421   555 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 594
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
556-594 2.48e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 2.48e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 119569421  556 RKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 594
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
439-622 2.60e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.47  E-value: 2.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 439 ITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGlNQLTVTTGSEGLLKFWNFKNKILI 518
Cdd:COG3391   25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADG-RRLYVANSGSGRVSVIDLATGKVV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421 519 HSVSLSSSPNIMLLHRDSGILGLA-LDDFSISVLDIETRKIVREFSGHqGQINDMAFSPDGRWLISAAMDCS-----IRT 592
Cdd:COG3391  104 ATIPVGGGPRGLAVDPDGGRLYVAdSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNtvsviVSV 182

                        170       180       190
                 ....*....|....*....|....*....|
gi 119569421 593 WDLPSGCLIDCFLLDSAPLNVSMSPTGDFL 622
Cdd:COG3391  183 IDTATGKVVATIPVGGGPVGVAVSPDGRRL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-217 3.25e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 3.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  93 ARNKEIVHTFKGHKAEIHFLQPFGD--HIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 169
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119569421 170 QGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAVGLMSGQVII 217
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 517-625 6.91e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 45.80  E-value: 6.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  517 LIHSVSLSSSPNIMLLHRDSGILGLA-LDDFSISVLDIETRKIVrefsghqGQIN------DMAFSPDGRWLISAAMDCS 589
Cdd:TIGR03866  75 VLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL-------AQIDvgvepeGMAVSPDGKIVVNTSETTN 147

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 119569421  590 IRTW-DLPSGCLIDCFLLDSAPLNVSMSPTGDFLATS 625
Cdd:TIGR03866 148 MAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 201-285 1.54e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119569421  201 PAVDVVAVGLMSGQVIIHNIKFNE--TLMKFRQDwGPITSISFRTDGHpVMAAGSPCGHIGLWDLEDKKLINQmRNAHST 278
Cdd:pfam12894   5 PTMDLIALATEDGELLLHRLNWQRvwTLSPDKED-LEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHH-FSAGSD 81


                  ....*..
gi 119569421  279 AIAGLTF 285
Cdd:pfam12894  82 LITCLGW 88
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 544-581 2.27e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.95  E-value: 2.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 119569421  544 DDFSISVLDIET---RKIVRefSGHQGQINDMAFSPDGRWL 581
Cdd:COG4946   408 NRGRLWVVDLASgkvRKVDT--DGYGDGISDLAWSPDSKWL 446
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-132 3.93e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 119569421    95 NKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWH 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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