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Conserved domains on  [gi|1195515964|ref|XP_021070902|]
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nuclear pore complex protein Nup153 [Mus pahari]

Protein Classification

zinc finger Ran-binding domain-containing protein( domain architecture ID 12094997)

zinc finger Ran-binding domain-containing protein similar to Arabidopsis thaliana chloroplastic zinc finger protein VAR3, which is involved in C-to-U editing of chloroplastic RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 114-617 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


:

Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 644.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  114 PSTTSTASNYPDVLTRPSLHRSHLNFSVLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 193
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  194 EKDIAVSKNTSLPPLWSPEAERSHSLSQHTAISSKKPAFNLSAFGTLSTSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 273
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  274 VRQNKVRSTPYQAPVRRQMKAKQLNAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSAVSSPLNSPLDRSGIDSTVFQA 353
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSTVSSPLSSPLDRSDLDITNFQS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  354 KKEKVDSQYPPVQRLMTPKPVSIATNRTVYFKPSLTPSGDLRKTNQRIDKKNSTVDEKSVSRQNREQ-ESGFSYPNFSIP 432
Cdd:pfam08604  240 KRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRETEVRQSPEQAVEPsESSLSYPKFSTP 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  433 AANGLSSGVGSGGGKMRRERTHFVAPKP-SENEEVEAPLLPQISLPIGSSSLPTFSFSSPAISASPSPVSSSQPLP-NKV 510
Cdd:pfam08604  320 ASNSLSSGGNGGGGKMRRERGRRPSSKPaEEDEVVEVPVLPKISLPISTASLPTFNFSSPTSSTSSSSPPSVTKSAeNKA 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  511 QMTSLGSTGSPVFTFSSPIVKSTQADVLPPA-SIGFTFSVPLAKT-EFSGSNSSSETVLSSPaqDNTAVNSSSYKK-RSA 587
Cdd:pfam08604  400 QKQPPSTSGSPAFTFSSPIVKSTEASVPPPSpSIGFTFSVPVAKTaELSGSSGTSVVSVVST--ETTTVNSTSNKKeEEE 477

                          490       500       510
                   ....*....|....*....|....*....|
gi 1195515964  588 PCEDPFTPAKILREGSVLDILKTPGFMSPK 617
Cdd:pfam08604  478 EFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1374-1464 1.31e-18

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


:

Pssm-ID: 371156  Cd Length: 86  Bit Score: 82.03  E-value: 1.31e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964 1374 GSGTANASSVFQFGSSTTNFNFTNNNPSGVFTFGASPSTPAASAQPSGSGVFSFSQSPASFTVGSNGKNMFsssgtSVSG 1453
Cdd:pfam10599    1 KEGTPDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSNMF-----SVSG 75

                           90
                   ....*....|.
gi 1195515964 1454 RKIKTAVRRRK 1464
Cdd:pfam10599   76 RKIAQMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
718-746 1.01e-09

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 54.67  E-value: 1.01e-09
                           10        20
                   ....*....|....*....|....*....
gi 1195515964  718 IGTWDCDTCLVQNKPEAVKCVACETPKPG 746
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
842-871 1.80e-08

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.20  E-value: 1.80e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 1195515964  842 PEGSWDCEVCLVQNKADSAKCIACESAKPG 871
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
785-814 1.21e-07

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 48.89  E-value: 1.21e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1195515964  785 PVGSWECPVCCVCNKAEDNRCVSCTSEKPG 814
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
657-683 3.07e-07

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.07e-07
                           10        20
                   ....*....|....*....|....*..
gi 1195515964  657 SWQCDTCLLQNKVTDNKCIACQAAKLP 683
Cdd:pfam00641    4 DWDCSKCLVQNFATSTKCVACQAPKPD 30
 
Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 114-617 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 644.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  114 PSTTSTASNYPDVLTRPSLHRSHLNFSVLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 193
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  194 EKDIAVSKNTSLPPLWSPEAERSHSLSQHTAISSKKPAFNLSAFGTLSTSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 273
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  274 VRQNKVRSTPYQAPVRRQMKAKQLNAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSAVSSPLNSPLDRSGIDSTVFQA 353
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSTVSSPLSSPLDRSDLDITNFQS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  354 KKEKVDSQYPPVQRLMTPKPVSIATNRTVYFKPSLTPSGDLRKTNQRIDKKNSTVDEKSVSRQNREQ-ESGFSYPNFSIP 432
Cdd:pfam08604  240 KRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRETEVRQSPEQAVEPsESSLSYPKFSTP 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  433 AANGLSSGVGSGGGKMRRERTHFVAPKP-SENEEVEAPLLPQISLPIGSSSLPTFSFSSPAISASPSPVSSSQPLP-NKV 510
Cdd:pfam08604  320 ASNSLSSGGNGGGGKMRRERGRRPSSKPaEEDEVVEVPVLPKISLPISTASLPTFNFSSPTSSTSSSSPPSVTKSAeNKA 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  511 QMTSLGSTGSPVFTFSSPIVKSTQADVLPPA-SIGFTFSVPLAKT-EFSGSNSSSETVLSSPaqDNTAVNSSSYKK-RSA 587
Cdd:pfam08604  400 QKQPPSTSGSPAFTFSSPIVKSTEASVPPPSpSIGFTFSVPVAKTaELSGSSGTSVVSVVST--ETTTVNSTSNKKeEEE 477

                          490       500       510
                   ....*....|....*....|....*....|
gi 1195515964  588 PCEDPFTPAKILREGSVLDILKTPGFMSPK 617
Cdd:pfam08604  478 EFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1374-1464 1.31e-18

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


Pssm-ID: 371156  Cd Length: 86  Bit Score: 82.03  E-value: 1.31e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964 1374 GSGTANASSVFQFGSSTTNFNFTNNNPSGVFTFGASPSTPAASAQPSGSGVFSFSQSPASFTVGSNGKNMFsssgtSVSG 1453
Cdd:pfam10599    1 KEGTPDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSNMF-----SVSG 75

                           90
                   ....*....|.
gi 1195515964 1454 RKIKTAVRRRK 1464
Cdd:pfam10599   76 RKIAQMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
718-746 1.01e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 54.67  E-value: 1.01e-09
                           10        20
                   ....*....|....*....|....*....
gi 1195515964  718 IGTWDCDTCLVQNKPEAVKCVACETPKPG 746
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
842-871 1.80e-08

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.20  E-value: 1.80e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 1195515964  842 PEGSWDCEVCLVQNKADSAKCIACESAKPG 871
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
785-814 1.21e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 48.89  E-value: 1.21e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1195515964  785 PVGSWECPVCCVCNKAEDNRCVSCTSEKPG 814
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
657-683 3.07e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.07e-07
                           10        20
                   ....*....|....*....|....*..
gi 1195515964  657 SWQCDTCLLQNKVTDNKCIACQAAKLP 683
Cdd:pfam00641    4 DWDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 719-743 1.13e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 43.46  E-value: 1.13e-05
                            10        20
                    ....*....|....*....|....*
gi 1195515964   719 GTWDCDTCLVQNKPEAVKCVACETP 743
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 787-808 5.65e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 41.15  E-value: 5.65e-05
                            10        20
                    ....*....|....*....|..
gi 1195515964   787 GSWECPVCCVCNKAEDNRCVSC 808
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFAC 22
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 844-866 8.20e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 40.76  E-value: 8.20e-05
                            10        20
                    ....*....|....*....|...
gi 1195515964   844 GSWDCEVCLVQNKADSAKCIACE 866
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACG 23
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 656-679 1.69e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.99  E-value: 1.69e-04
                            10        20
                    ....*....|....*....|....
gi 1195515964   656 SSWQCDTCLLQNKVTDNKCIACQA 679
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGA 24
 
Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 114-617 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 644.63  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  114 PSTTSTASNYPDVLTRPSLHRSHLNFSVLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 193
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  194 EKDIAVSKNTSLPPLWSPEAERSHSLSQHTAISSKKPAFNLSAFGTLSTSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 273
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  274 VRQNKVRSTPYQAPVRRQMKAKQLNAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSAVSSPLNSPLDRSGIDSTVFQA 353
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSTVSSPLSSPLDRSDLDITNFQS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  354 KKEKVDSQYPPVQRLMTPKPVSIATNRTVYFKPSLTPSGDLRKTNQRIDKKNSTVDEKSVSRQNREQ-ESGFSYPNFSIP 432
Cdd:pfam08604  240 KRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRETEVRQSPEQAVEPsESSLSYPKFSTP 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  433 AANGLSSGVGSGGGKMRRERTHFVAPKP-SENEEVEAPLLPQISLPIGSSSLPTFSFSSPAISASPSPVSSSQPLP-NKV 510
Cdd:pfam08604  320 ASNSLSSGGNGGGGKMRRERGRRPSSKPaEEDEVVEVPVLPKISLPISTASLPTFNFSSPTSSTSSSSPPSVTKSAeNKA 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964  511 QMTSLGSTGSPVFTFSSPIVKSTQADVLPPA-SIGFTFSVPLAKT-EFSGSNSSSETVLSSPaqDNTAVNSSSYKK-RSA 587
Cdd:pfam08604  400 QKQPPSTSGSPAFTFSSPIVKSTEASVPPPSpSIGFTFSVPVAKTaELSGSSGTSVVSVVST--ETTTVNSTSNKKeEEE 477

                          490       500       510
                   ....*....|....*....|....*....|
gi 1195515964  588 PCEDPFTPAKILREGSVLDILKTPGFMSPK 617
Cdd:pfam08604  478 EFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1374-1464 1.31e-18

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


Pssm-ID: 371156  Cd Length: 86  Bit Score: 82.03  E-value: 1.31e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964 1374 GSGTANASSVFQFGSSTTNFNFTNNNPSGVFTFGASPSTPAASAQPSGSGVFSFSQSPASFTVGSNGKNMFsssgtSVSG 1453
Cdd:pfam10599    1 KEGTPDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSNMF-----SVSG 75

                           90
                   ....*....|.
gi 1195515964 1454 RKIKTAVRRRK 1464
Cdd:pfam10599   76 RKIAQMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
718-746 1.01e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 54.67  E-value: 1.01e-09
                           10        20
                   ....*....|....*....|....*....
gi 1195515964  718 IGTWDCDTCLVQNKPEAVKCVACETPKPG 746
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
842-871 1.80e-08

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.20  E-value: 1.80e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 1195515964  842 PEGSWDCEVCLVQNKADSAKCIACESAKPG 871
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
785-814 1.21e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 48.89  E-value: 1.21e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1195515964  785 PVGSWECPVCCVCNKAEDNRCVSCTSEKPG 814
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
657-683 3.07e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.07e-07
                           10        20
                   ....*....|....*....|....*..
gi 1195515964  657 SWQCDTCLLQNKVTDNKCIACQAAKLP 683
Cdd:pfam00641    4 DWDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 719-743 1.13e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 43.46  E-value: 1.13e-05
                            10        20
                    ....*....|....*....|....*
gi 1195515964   719 GTWDCDTCLVQNKPEAVKCVACETP 743
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 787-808 5.65e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 41.15  E-value: 5.65e-05
                            10        20
                    ....*....|....*....|..
gi 1195515964   787 GSWECPVCCVCNKAEDNRCVSC 808
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFAC 22
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 844-866 8.20e-05

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 40.76  E-value: 8.20e-05
                            10        20
                    ....*....|....*....|...
gi 1195515964   844 GSWDCEVCLVQNKADSAKCIACE 866
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACG 23
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 656-679 1.69e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.99  E-value: 1.69e-04
                            10        20
                    ....*....|....*....|....
gi 1195515964   656 SSWQCDTCLLQNKVTDNKCIACQA 679
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGA 24
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1322-1457 4.50e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 4.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1195515964 1322 ASQPNPPSFGSISSSTALFSAGSQPVP----PPTFGTVSSSSQPPVFGQQPSQSAFGSGTANASSVFQFGSSTTNfnftn 1397
Cdd:pfam03154  388 SNLPPPPALKPLSSLSTHHPPSAHPPPlqlmPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPF----- 462

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1195515964 1398 nnPSGVFTFGASPS-TPAASAQPSGSGVFSFSQSPASFTVGSNGkNMFSSSGTSVSGRKIK 1457
Cdd:pfam03154  463 --PQHPFVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSG-PVPAAVSCPLPPVQIK 520
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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