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Conserved domains on  [gi|119392098|ref|NP_062514|]
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C-X-C motif chemokine 14 precursor [Mus musculus]

Protein Classification

CC/CxC family chemokine( domain architecture ID 10441213)

CC/CxC family chemokine similar to human C-X-C motif chemokine 14, which is preferentially expressed in normal vs malignant tissue and as a chemokine is involved in the regulation of leukocyte infiltration into inflamed tissue and may affect disease processes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
33-86 4.17e-06

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


:

Pssm-ID: 459650  Cd Length: 60  Bit Score: 40.71  E-value: 4.17e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119392098  33 KIRYSDVKKLEMKPKYPHCEEKMVIVTTKsmsryRGQEHCLHPKLQSTKRFIKW 86
Cdd:pfam00048 11 PIPLKRVKSYEIQPASSSCPKPAVIFLTK-----KGRQVCADPKAKWVQRLIKK 59
 
Name Accession Description Interval E-value
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
33-86 4.17e-06

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 40.71  E-value: 4.17e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119392098  33 KIRYSDVKKLEMKPKYPHCEEKMVIVTTKsmsryRGQEHCLHPKLQSTKRFIKW 86
Cdd:pfam00048 11 PIPLKRVKSYEIQPASSSCPKPAVIFLTK-----KGRQVCADPKAKWVQRLIKK 59
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
24-85 5.02e-05

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238171  Cd Length: 64  Bit Score: 38.01  E-value: 5.02e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119392098 24 KCKCSRKGPK-IRYSDVKKLEMKPKYPHCEEKMVIVTTKSmsryrGQEHCLHPKLQSTKRFIK 85
Cdd:cd00273   3 RCRCIKTTSGfVHPKSIKKLEVIPPGPHCPNTEIIATLKN-----GRKVCLNPEAPWVQKIIK 60
 
Name Accession Description Interval E-value
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
33-86 4.17e-06

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 40.71  E-value: 4.17e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119392098  33 KIRYSDVKKLEMKPKYPHCEEKMVIVTTKsmsryRGQEHCLHPKLQSTKRFIKW 86
Cdd:pfam00048 11 PIPLKRVKSYEIQPASSSCPKPAVIFLTK-----KGRQVCADPKAKWVQRLIKK 59
Chemokine_CXC cd00273
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
24-85 5.02e-05

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238171  Cd Length: 64  Bit Score: 38.01  E-value: 5.02e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119392098 24 KCKCSRKGPK-IRYSDVKKLEMKPKYPHCEEKMVIVTTKSmsryrGQEHCLHPKLQSTKRFIK 85
Cdd:cd00273   3 RCRCIKTTSGfVHPKSIKKLEVIPPGPHCPNTEIIATLKN-----GRKVCLNPEAPWVQKIIK 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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