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Conserved domains on  [gi|119369490|sp|Q6QEF8|]
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RecName: Full=Coronin-6; AltName: Full=Coronin-like protein E; Short=Clipin-E

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-454 4.05e-107

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 326.85  E-value: 4.05e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490   9 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  88 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVL 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 168 LSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeQARPHEGARPLRAVFTADGKLLST-GFSRMSERQL 246
Cdd:PTZ00421 162 EVIKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITlGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 247 ALWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPKRGL 326
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 327 DVSKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVP---- 397
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPelmg 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 398 ---------PKHRELRVTKRNILDVRPPS-------------GPRRSQSASDAPLSQQHTLETLL----EEIKALRERVQ 451
Cdd:PTZ00421 398 asalspsgkPRHSGVSVPASTSAMTHSFDdntskhadpcamgVKRMDEGILDERLGRLQALSEKLrtqhEEIKRCREALQ 477


                 ...
gi 119369490 452 AQE 454
Cdd:PTZ00421 478 KKE 480
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-454 4.05e-107

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 326.85  E-value: 4.05e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490   9 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  88 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVL 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 168 LSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeQARPHEGARPLRAVFTADGKLLST-GFSRMSERQL 246
Cdd:PTZ00421 162 EVIKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITlGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 247 ALWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPKRGL 326
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 327 DVSKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVP---- 397
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPelmg 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 398 ---------PKHRELRVTKRNILDVRPPS-------------GPRRSQSASDAPLSQQHTLETLL----EEIKALRERVQ 451
Cdd:PTZ00421 398 asalspsgkPRHSGVSVPASTSAMTHSFDdntskhadpcamgVKRMDEGILDERLGRLQALSEKLrtqhEEIKRCREALQ 477


                 ...
gi 119369490 452 AQE 454
Cdd:PTZ00421 478 KKE 480
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 3.96e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 3.96e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119369490    4 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-296 3.03e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 3.03e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  78 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 158 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeQARPHEGarPLRAV-FTADGKLLST 236
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVaFSPDGEKLLS 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 237 GFsrmSERQLALWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 296
Cdd:cd00200  195 SS---SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
78-298 1.22e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 1.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:COG2319  117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 158 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEqaRPHEGARPLRAVFTADGKLLSTG 237
Cdd:COG2319  188 LWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT--LTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119369490 238 fsrMSERQLALWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 298
Cdd:COG2319  265 ---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-109 2.03e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.03e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 119369490    78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 109
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-454 4.05e-107

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 326.85  E-value: 4.05e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490   9 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  88 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVL 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 168 LSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeQARPHEGARPLRAVFTADGKLLST-GFSRMSERQL 246
Cdd:PTZ00421 162 EVIKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITlGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 247 ALWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPKRGL 326
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 327 DVSKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVP---- 397
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPelmg 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 398 ---------PKHRELRVTKRNILDVRPPS-------------GPRRSQSASDAPLSQQHTLETLL----EEIKALRERVQ 451
Cdd:PTZ00421 398 asalspsgkPRHSGVSVPASTSAMTHSFDdntskhadpcamgVKRMDEGILDERLGRLQALSEKLrtqhEEIKRCREALQ 477


                 ...
gi 119369490 452 AQE 454
Cdd:PTZ00421 478 KKE 480
PTZ00420 PTZ00420
coronin; Provisional
 21-408 1.10e-68

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 229.07  E-value: 1.10e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  21 ADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGRvdkNYPLVT--GHTAPVLDIDWCPHNDNVIA 98
Cdd:PTZ00420  15 SNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSEILA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  99 SASDDTTIMVWQIP-DYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLddMHPDV 177
Cdd:PTZ00420  92 SGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI--NMPKK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 178 IHSVCWNSNGSLLATTCKDKTLRIIDPRKgQVVAEQARPHEGARPLRAVFT-----ADGKLLSTGFSRMSERQLALWDPN 252
Cdd:PTZ00420 170 LSSLKWNIKGNLLSGTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLK 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 253 NFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPpfVHYLNTFSSKEPQRGMGFMPKRGLDVSKCE 332
Cdd:PTZ00420 249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119369490 333 IARFYK-LHERKCEPIIMTVPRK-SDLFQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLRDgyvpPKHRELRVTKR 408
Cdd:PTZ00420 327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKK 400
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 3.96e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 3.96e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119369490    4 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-296 3.03e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 3.03e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  78 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 158 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeQARPHEGarPLRAV-FTADGKLLST 236
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVaFSPDGEKLLS 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 237 GFsrmSERQLALWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 296
Cdd:cd00200  195 SS---SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
78-298 1.22e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 1.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:COG2319  117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 158 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEqaRPHEGARPLRAVFTADGKLLSTG 237
Cdd:COG2319  188 LWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT--LTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119369490 238 fsrMSERQLALWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 298
Cdd:COG2319  265 ---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
77-292 3.59e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 3.59e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  77 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 156
Cdd:COG2319  200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 157 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEqaRPHEGARPLRAVFTADGKLLST 236
Cdd:COG2319  271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSVAFSPDGKTLAS 347

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119369490 237 GFsrmSERQLALWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 292
Cdd:COG2319  348 GS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-295 2.38e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 2.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  35 WDSSFCAVNPKFLAiiveAGGGGAFIVLPLaKTGRVDKNYplvTGHTAPVLDIDWCPHNDnVIASASDDTTIMVWQIPDY 114
Cdd:cd00200   55 RDVAASADGTYLAS----GSSDKTIRLWDL-ETGECVRTL---TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 115 tpmrnitEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTC 194
Cdd:cd00200  126 -------KCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 195 KDKTLRIIDPRKGQVVAeQARPHEGarPLRAV-FTADGKLLSTGFsrmSERQLALWDPNNFEEPVALQEmdTSNGVLLPF 273
Cdd:cd00200  197 SDGTIKLWDLSTGKCLG-TLRGHEN--GVNSVaFSPDGYLLASGS---EDGTIRVWDLRTGECVQTLSG--HTNSVTSLA 268

                        250       260
                 ....*....|....*....|..
gi 119369490 274 YDPDSSIVYLCGKgDSSIRYFE 295
Cdd:cd00200  269 WSPDGKRLASGSA-DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
77-292 4.23e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 4.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  77 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 156
Cdd:COG2319   74 LLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT-------GLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 157 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEqARPHEGaRPLRAVFTADGKLLST 236
Cdd:COG2319  145 RLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTG-AVRSVAFSPDGKLLAS 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119369490 237 GFsrmSERQLALWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 292
Cdd:COG2319  222 GS---ADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASGS-ADGTVR 271
WD40 COG2319
WD40 repeat [General function prediction only];
76-205 3.83e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 3.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  76 LVTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDYTPMRnitepiiTLEGHSKRVGILSWHPTARnVLLSAGGDNV 155
Cdd:COG2319  283 TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPDGK-TLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 119369490 156 IIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPR 205
Cdd:COG2319  354 VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 344-386 1.82e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 84.10  E-value: 1.82e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 119369490  344 CEPIIMTVPRKS-DLFQDDLYPDTPGPEPALEADEWLSGQDAEP 386
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-292 1.28e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 1.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 123 PIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRII 202
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 203 DPRKGQVVAEQaRPHEGarPLRAV-FTADGKLLSTGfsrMSERQLALWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIV 281
Cdd:cd00200   79 DLETGECVRTL-TGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFV 150

                        170
                 ....*....|.
gi 119369490 282 YlCGKGDSSIR 292
Cdd:cd00200  151 A-SSSQDGTIK 160
WD40 COG2319
WD40 repeat [General function prediction only];
78-163 5.51e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 5.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:COG2319  327 TGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVR 397


                 ....*.
gi 119369490 158 IWNVGT 163
Cdd:COG2319  398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 174-298 9.09e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 9.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 174 HPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEQaRPHEGarPLRAV-FTADGK-LLSTGfsrmSERQLALWDP 251
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTG--PVRDVaASADGTyLASGS----SDKTIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 119369490 252 NNFEEPVALqEMDTSnGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 298
Cdd:cd00200   81 ETGECVRTL-TGHTS-YVSSVAFSPDGRIL-SSSSRDKTIKVWDVET 124
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-109 2.03e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.03e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 119369490    78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 109
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 163-203 3.99e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.99e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 119369490   163 TGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIID 203
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 89-186 1.16e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.81  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490   89 WCPHNDnVIASASDDTTI--------MVWQIPdytpmrnitepiitLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWN 160
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 119369490  161 VGTGEVLLSLdDMHPDVIHSVCWNSN 186
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 122-160 1.35e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.35e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 119369490   122 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 160
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
118-261 1.45e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 118 RNITEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDK 197
Cdd:COG2319   23 AALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLG-HTAAVLSVAFSPDGRLLASASADG 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119369490 198 TLRIIDPRKGQVVAeQARPHEGArPLRAVFTADGKLLSTGFsrmSERQLALWDPNNFEEPVALQ 261
Cdd:COG2319  101 TVRLWDLATGLLLR-TLTGHTGA-VRSVAFSPDGKTLASGS---ADGTVRLWDLATGKLLRTLT 159
WD40 pfam00400
WD domain, G-beta repeat;
78-109 2.54e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.54e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119369490   78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 109
Cdd:pfam00400   8 EGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
174-203 1.46e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.46e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 119369490  174 HPDVIHSVCWNSNGSLLATTCKDKTLRIID 203
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
122-160 1.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 119369490  122 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 160
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
33-234 7.67e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 7.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490  33 VTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGRVDKNYPLVTGHTAPVLDIDwcpHNDNVIASASDDTTIMVWQIP 112
Cdd:COG3391   22 AVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGA---DGRRLYVANSGSGRVSVIDLA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119369490 113 DYTPMRNITepiitLEGHSKRVGIlswHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDdmHPDVIHSVCWNSNGSLLAT 192
Cdd:COG3391   99 TGKVVATIP-----VGGGPRGLAV---DPDGGRLYVADSGNGRVSVIDTATGKVVATIP--VGAGPHGIAVDPDGKRLYV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 119369490 193 TCKD-----KTLRIIDPRKGQVVaeqARPHEGARPLRAVFTADGKLL 234
Cdd:COG3391  169 ANSGsntvsVIVSVIDTATGKVV---ATIPVGGGPVGVAVSPDGRRL 212
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 178-210 4.73e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 4.73e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 119369490  178 IHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVV 210
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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