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Conserved domains on  [gi|119360|sp|P14625|]
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RecName: Full=Endoplasmin; AltName: Full=94 kDa glucose-regulated protein; Short=GRP-94; AltName: Full=Heat shock protein 90 kDa beta member 1; AltName: Full=Heat shock protein family C member 4; AltName: Full=Tumor rejection antigen 1; AltName: Full=gp96 homolog; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HSP90 pfam00183
Hsp90 protein;
257-755 0e+00

Hsp90 protein;


:

Pssm-ID: 459703  Cd Length: 516  Bit Score: 780.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     257 DYLELDTIKNLVKKYSQFINFPIYVWSSKTETV-EEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWEL 335
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVeVPDEEEEEEEEEEEEEDDDPKVEEEDEEEEKKKTKKVKETVWEWEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     336 MNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYgsKKSDYIKLYVRR 415
Cdd:pfam00183  81 LNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEGEVEFKSLLFIPKRAPFDLFENK--KKKNNIKLYVRR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     416 VFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYN-DTFWKEFGTNIKL 494
Cdd:pfam00183 159 VFITDDFEDLIPEYLNFVKGVVDSDDLPLNVSRETLQQNKILKVIKKKLVRKALDMFKEIAEEKEDyKKFWKEFGKNLKL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     495 GVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDE 574
Cdd:pfam00183 239 GIIEDSSNRNKLAKLLRFYSSKSGDELTSLDDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKKGYEVLYLTDPIDE 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     575 YCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDkALKDKIEKAVVSQRLTESPCALVASQYGW 654
Cdd:pfam00183 319 YAVQQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKD-VLGDKVEKVVVSNRLVDSPCVLVTSQYGW 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     655 SGNMERIMKAQAYQtgKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKA 734
Cdd:pfam00183 398 SANMERIMKAQALR--KDSSMSSYMSSKKTLEINPRHPIIKELLKRVEADKDDKTAKDLALLLYETALLRSGFSLEDPAS 475
                         490       500
                  ....*....|....*....|.
gi 119360     735 YGDRIERMLRLSLNIDPDAKV 755
Cdd:pfam00183 476 FASRIYRMLKLGLGIDEDEIV 496
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
83-275 9.03e-99

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


:

Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 304.06  E-value: 9.03e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    83 NRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKN 162
Cdd:cd16927   1 NQLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   163 LGTIAKSGTSEFLNKMTEAQEDgqstSELIGQFGVGFYSAFLVADKVIVTSKHN-NDTQHIWESDSNEFSVIADPRGNtL 241
Cdd:cd16927  81 LGTIARSGTKAFLEALQEGAKD----SDLIGQFGVGFYSAFMVADKVTVTTKSAgDDEGYRWESDGGGSYTIEEAEGE-L 155
                       170       180       190
                ....*....|....*....|....*....|....
gi 119360   242 GRGTTITLVLKEEASDYLELDTIKNLVKKYSQFI 275
Cdd:cd16927 156 GRGTKITLHLKEDAKEFLEEARIKELVKKYSDFI 189
 
Name Accession Description Interval E-value
HSP90 pfam00183
Hsp90 protein;
257-755 0e+00

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 780.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     257 DYLELDTIKNLVKKYSQFINFPIYVWSSKTETV-EEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWEL 335
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVeVPDEEEEEEEEEEEEEDDDPKVEEEDEEEEKKKTKKVKETVWEWEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     336 MNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYgsKKSDYIKLYVRR 415
Cdd:pfam00183  81 LNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEGEVEFKSLLFIPKRAPFDLFENK--KKKNNIKLYVRR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     416 VFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYN-DTFWKEFGTNIKL 494
Cdd:pfam00183 159 VFITDDFEDLIPEYLNFVKGVVDSDDLPLNVSRETLQQNKILKVIKKKLVRKALDMFKEIAEEKEDyKKFWKEFGKNLKL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     495 GVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDE 574
Cdd:pfam00183 239 GIIEDSSNRNKLAKLLRFYSSKSGDELTSLDDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKKGYEVLYLTDPIDE 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     575 YCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDkALKDKIEKAVVSQRLTESPCALVASQYGW 654
Cdd:pfam00183 319 YAVQQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKD-VLGDKVEKVVVSNRLVDSPCVLVTSQYGW 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     655 SGNMERIMKAQAYQtgKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKA 734
Cdd:pfam00183 398 SANMERIMKAQALR--KDSSMSSYMSSKKTLEINPRHPIIKELLKRVEADKDDKTAKDLALLLYETALLRSGFSLEDPAS 475
                         490       500
                  ....*....|....*....|.
gi 119360     735 YGDRIERMLRLSLNIDPDAKV 755
Cdd:pfam00183 476 FASRIYRMLKLGLGIDEDEIV 496
PRK05218 PRK05218
heat shock protein 90; Provisional
74-746 0e+00

heat shock protein 90; Provisional


Pssm-ID: 235366 [Multi-domain]  Cd Length: 613  Bit Score: 714.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     74 EKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVG 153
Cdd:PRK05218   4 ETGEFQAEVKQLLHLMIHSLYSNKEIFLRELISNASDAIDKLRFEALTDPALYEGDGDLKIRISFDKEARTLTISDNGIG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    154 MTREELVKNLGTIAKSGTSEFLNKMTEAQEDGqstSELIGQFGVGFYSAFLVADKVIVTSKH--NNDTQHIWESD-SNEF 230
Cdd:PRK05218  84 MTREEVIENLGTIAKSGTKEFLEKLKGDQKKD---SQLIGQFGVGFYSAFMVADKVTVITRSagPAAEAVRWESDgEGEY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    231 SvIADPRGNTlgRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWssktetveepmeeeeaakeekeesddea 310
Cdd:PRK05218 161 T-IEEIEKEE--RGTEITLHLKEDEDEFLDEWRIRSIIKKYSDFIPVPIKLE---------------------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    311 aveeeeeekkpktkkvektVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVP 390
Cdd:PRK05218 210 -------------------KEEEETINSASALWTRSKSEITDEEYKEFYKHLAHDFDDPLFWIHNNVEGPFEYTGLLYIP 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    391 TSAPRGLFD-EYGSKksdyIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTL 469
Cdd:PRK05218 271 KKAPFDLFNrDRKGG----LKLYVKRVFIMDDAEELLPEYLRFVKGVIDSEDLPLNVSREILQEDRVVKKIRKAITKKVL 346
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    470 DMIKKIADD---KYNdTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHpTDITSLDQYVERMKEKQDKIYFMAGSSR 546
Cdd:PRK05218 347 DELEKLAKNdreKYE-KFWKEFGPVLKEGLYEDFANREKLAKLLRFASTHE-GKYVSLAEYVERMKEGQKKIYYITGDSR 424
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    547 KEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFD-ESEKTKESREAVEKEFEPLLNWMKdK 625
Cdd:PRK05218 425 EAAKNSPHLELFKKKGIEVLLLTDPIDEFWISYLEEFDGKPFKSVARGDLDLGkEDEEEKEEKEEAEEEFKPLLERLK-E 503
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    626 ALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKaQAYQTGKDIstnyyasqKKTFEINPRHPLIrdmlRRIKEDE 705
Cdd:PRK05218 504 ALGDKVKDVRLSHRLTDSPACLVADEGDMSTQMEKLLK-AAGQEVPES--------KPILEINPNHPLV----KKLADEA 570
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 119360    706 DDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRI-ERMLRLS 746
Cdd:PRK05218 571 DEAKFKDLAELLYDQALLAEGGSLEDPAAFVKRLnELLLKLL 612
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
72-748 0e+00

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 713.43  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    72 KSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTG 151
Cdd:COG0326   2 AKETGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   152 VGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGqstSELIGQFGVGFYSAFLVADKVIVTSK-HNNDTQ-HIWESD-SN 228
Cdd:COG0326  82 IGMTREEVIENLGTIAKSGTREFLEKLKGDQKKD---SDLIGQFGVGFYSAFMVADKVEVVTRsAGEDAEaVRWESDgDG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   229 EFSVIADPRgntLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVeepmeeeeaakeekeesdd 308
Cdd:COG0326 159 EYTIEEAEK---AERGTEITLHLKEDAEEFLEEWRLREIIKKYSDFIPVPIKMEGEEEETE------------------- 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   309 eaaveeeeeekkpktkkvektvwDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILF 388
Cdd:COG0326 217 -----------------------EDETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDPLFWIHLNVEGPFEYTGLLY 273
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   389 VPTSAPRGLFDEYGSKKsdyIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKT 468
Cdd:COG0326 274 IPKKAPFDLYDRDRKGG---IKLYVKRVFIMDDAEDLLPEYLRFVRGVVDSPDLPLNVSREILQEDRQLKKIRKAITKKV 350
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   469 LDMIKKIADD---KYNdTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHhPTDITSLDQYVERMKEKQDKIYFMAGSS 545
Cdd:COG0326 351 LDELEKLAKNdreKYE-KFWKEFGLVLKEGALEDFKNREKIADLLRFESTK-EGGYVTLAEYVERMKEGQKKIYYITGES 428
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   546 RKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESrEAVEKEFEPLLNWMKdK 625
Cdd:COG0326 429 REAAEQSPHLEIFKAKGIEVLLLTDPIDEFLISHLEEFDGKKFKSVDSGDLDLDKLEEKKES-EEEEEEFKPLLERFK-E 506
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   626 ALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQayqtGKDIStnyyaSQKKTFEINPRHPLIrdmlRRIKEDE 705
Cdd:COG0326 507 ALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKAM----GQDMP-----EAKPILEINPNHPLV----KKLAAEE 573
                       650       660       670       680
                ....*....|....*....|....*....|....*....|...
gi 119360   706 DDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLN 748
Cdd:COG0326 574 DEELFKDLAELLYDQALLAEGGLLEDPAAFVKRLNKLLEKALG 616
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
83-275 9.03e-99

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 304.06  E-value: 9.03e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    83 NRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKN 162
Cdd:cd16927   1 NQLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   163 LGTIAKSGTSEFLNKMTEAQEDgqstSELIGQFGVGFYSAFLVADKVIVTSKHN-NDTQHIWESDSNEFSVIADPRGNtL 241
Cdd:cd16927  81 LGTIARSGTKAFLEALQEGAKD----SDLIGQFGVGFYSAFMVADKVTVTTKSAgDDEGYRWESDGGGSYTIEEAEGE-L 155
                       170       180       190
                ....*....|....*....|....*....|....
gi 119360   242 GRGTTITLVLKEEASDYLELDTIKNLVKKYSQFI 275
Cdd:cd16927 156 GRGTKITLHLKEDAKEFLEEARIKELVKKYSDFI 189
PRK14083 PRK14083
HSP90 family protein; Provisional
77-464 1.09e-27

HSP90 family protein; Provisional


Pssm-ID: 237603 [Multi-domain]  Cd Length: 601  Bit Score: 118.89  E-value: 1.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     77 AFQAEVNRMMKLIINSLYKNKEIFLRELISNASDAldkIRLISLTDENAlsgNEELTVKIKCDKEKNLLhVTDTGVGMTR 156
Cdd:PRK14083   4 RFQVDLRGVIDLLSRHLYSSPRVYVRELLQNAVDA---ITARRALDPTA---PGRIRIELTDAGGGTLI-VEDNGIGLTE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    157 EELVKNLGTIAKSGTSEflnkmteaQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHI-W--ESDSNeFSVI 233
Cdd:PRK14083  77 EEVHEFLATIGRSSKRD--------ENLGFARNDFLGQFGIGLLSCFLVADEIVVVSRSAKDGPAVeWrgKADGT-YSVR 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    234 ADPrGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVwssktetveepmeeeeaakeekeesddeaave 313
Cdd:PRK14083 148 KLE-TERAEPGTTVYLRPRPDAEEWLERETVEELAKKYGSLLPVPIRV-------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    314 eeeeekkpktkkvektVWDWELMNDIKPIWQR--PSKEVEEDEYKAFYKS-FSKEsddPMAYIHFTAEGEVTFkSILFV- 389
Cdd:PRK14083 195 ----------------EGEKGGVNETPPPWTRdyPDPETRREALLAYGEElLGFT---PLDVIPLDVPSGGLE-GVAYVl 254
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119360    390 PTSAPrglfdeYGSKKSDyiKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKL 464
Cdd:PRK14083 255 PYAVS------PAARRKH--RVYLKRMLLSEEAENLLPDWAFFVRCVVNTDELRPTASREALYEDDALAAVREEL 321
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
96-254 5.09e-09

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 54.58  E-value: 5.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360       96 NKEIFLRELISNASDaldkirlisltdeNAL---SGNEELTVKIKCDKEKNLLHVTDTGVGMTREElvknlgtiaksgts 172
Cdd:smart00387   1 GDPDRLRQVLSNLLD-------------NAIkytPEGGRITVTLERDGDHVEITVEDNGPGIPPED-------------- 53
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360      173 efLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNndtqhiwesdsnefsviadprgNTLGRGTTITLVLK 252
Cdd:smart00387  54 --LEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVELHGGEISVE----------------------SEPGGGTTFTITLP 109

                   ..
gi 119360      253 EE 254
Cdd:smart00387 110 LE 111
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
124-222 8.41e-06

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 46.17  E-value: 8.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     124 NALSGNEElTVKIKCDKEKNL---LHVTDTGVGMTREELVKNLGtIAKSgtseflNKMTEAQEDGqstselIGQFGVGFY 200
Cdd:pfam13589  11 NSIDADAT-NIKIEVNKNRGGgteIVIEDDGHGMSPEELINALR-LATS------AKEAKRGSTD------LGRYGIGLK 76
                          90       100
                  ....*....|....*....|...
gi 119360     201 SAFLV-ADKVIVTSKHNNDTQHI 222
Cdd:pfam13589  77 LASLSlGAKLTVTSKKEGKSSTL 99
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
125-165 1.92e-03

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 41.39  E-value: 1.92e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 119360   125 ALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELvKNLGT 165
Cdd:COG5806 326 AMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQL-ERLGE 365
 
Name Accession Description Interval E-value
HSP90 pfam00183
Hsp90 protein;
257-755 0e+00

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 780.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     257 DYLELDTIKNLVKKYSQFINFPIYVWSSKTETV-EEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWEL 335
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVeVPDEEEEEEEEEEEEEDDDPKVEEEDEEEEKKKTKKVKETVWEWEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     336 MNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYgsKKSDYIKLYVRR 415
Cdd:pfam00183  81 LNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEGEVEFKSLLFIPKRAPFDLFENK--KKKNNIKLYVRR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     416 VFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYN-DTFWKEFGTNIKL 494
Cdd:pfam00183 159 VFITDDFEDLIPEYLNFVKGVVDSDDLPLNVSRETLQQNKILKVIKKKLVRKALDMFKEIAEEKEDyKKFWKEFGKNLKL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     495 GVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDE 574
Cdd:pfam00183 239 GIIEDSSNRNKLAKLLRFYSSKSGDELTSLDDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKKGYEVLYLTDPIDE 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     575 YCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDkALKDKIEKAVVSQRLTESPCALVASQYGW 654
Cdd:pfam00183 319 YAVQQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKD-VLGDKVEKVVVSNRLVDSPCVLVTSQYGW 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     655 SGNMERIMKAQAYQtgKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKA 734
Cdd:pfam00183 398 SANMERIMKAQALR--KDSSMSSYMSSKKTLEINPRHPIIKELLKRVEADKDDKTAKDLALLLYETALLRSGFSLEDPAS 475
                         490       500
                  ....*....|....*....|.
gi 119360     735 YGDRIERMLRLSLNIDPDAKV 755
Cdd:pfam00183 476 FASRIYRMLKLGLGIDEDEIV 496
PRK05218 PRK05218
heat shock protein 90; Provisional
74-746 0e+00

heat shock protein 90; Provisional


Pssm-ID: 235366 [Multi-domain]  Cd Length: 613  Bit Score: 714.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     74 EKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVG 153
Cdd:PRK05218   4 ETGEFQAEVKQLLHLMIHSLYSNKEIFLRELISNASDAIDKLRFEALTDPALYEGDGDLKIRISFDKEARTLTISDNGIG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    154 MTREELVKNLGTIAKSGTSEFLNKMTEAQEDGqstSELIGQFGVGFYSAFLVADKVIVTSKH--NNDTQHIWESD-SNEF 230
Cdd:PRK05218  84 MTREEVIENLGTIAKSGTKEFLEKLKGDQKKD---SQLIGQFGVGFYSAFMVADKVTVITRSagPAAEAVRWESDgEGEY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    231 SvIADPRGNTlgRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWssktetveepmeeeeaakeekeesddea 310
Cdd:PRK05218 161 T-IEEIEKEE--RGTEITLHLKEDEDEFLDEWRIRSIIKKYSDFIPVPIKLE---------------------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    311 aveeeeeekkpktkkvektVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVP 390
Cdd:PRK05218 210 -------------------KEEEETINSASALWTRSKSEITDEEYKEFYKHLAHDFDDPLFWIHNNVEGPFEYTGLLYIP 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    391 TSAPRGLFD-EYGSKksdyIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTL 469
Cdd:PRK05218 271 KKAPFDLFNrDRKGG----LKLYVKRVFIMDDAEELLPEYLRFVKGVIDSEDLPLNVSREILQEDRVVKKIRKAITKKVL 346
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    470 DMIKKIADD---KYNdTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHpTDITSLDQYVERMKEKQDKIYFMAGSSR 546
Cdd:PRK05218 347 DELEKLAKNdreKYE-KFWKEFGPVLKEGLYEDFANREKLAKLLRFASTHE-GKYVSLAEYVERMKEGQKKIYYITGDSR 424
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    547 KEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFD-ESEKTKESREAVEKEFEPLLNWMKdK 625
Cdd:PRK05218 425 EAAKNSPHLELFKKKGIEVLLLTDPIDEFWISYLEEFDGKPFKSVARGDLDLGkEDEEEKEEKEEAEEEFKPLLERLK-E 503
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    626 ALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKaQAYQTGKDIstnyyasqKKTFEINPRHPLIrdmlRRIKEDE 705
Cdd:PRK05218 504 ALGDKVKDVRLSHRLTDSPACLVADEGDMSTQMEKLLK-AAGQEVPES--------KPILEINPNHPLV----KKLADEA 570
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 119360    706 DDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRI-ERMLRLS 746
Cdd:PRK05218 571 DEAKFKDLAELLYDQALLAEGGSLEDPAAFVKRLnELLLKLL 612
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
72-748 0e+00

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 713.43  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    72 KSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTG 151
Cdd:COG0326   2 AKETGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   152 VGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGqstSELIGQFGVGFYSAFLVADKVIVTSK-HNNDTQ-HIWESD-SN 228
Cdd:COG0326  82 IGMTREEVIENLGTIAKSGTREFLEKLKGDQKKD---SDLIGQFGVGFYSAFMVADKVEVVTRsAGEDAEaVRWESDgDG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   229 EFSVIADPRgntLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVeepmeeeeaakeekeesdd 308
Cdd:COG0326 159 EYTIEEAEK---AERGTEITLHLKEDAEEFLEEWRLREIIKKYSDFIPVPIKMEGEEEETE------------------- 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   309 eaaveeeeeekkpktkkvektvwDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILF 388
Cdd:COG0326 217 -----------------------EDETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDPLFWIHLNVEGPFEYTGLLY 273
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   389 VPTSAPRGLFDEYGSKKsdyIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKT 468
Cdd:COG0326 274 IPKKAPFDLYDRDRKGG---IKLYVKRVFIMDDAEDLLPEYLRFVRGVVDSPDLPLNVSREILQEDRQLKKIRKAITKKV 350
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   469 LDMIKKIADD---KYNdTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHhPTDITSLDQYVERMKEKQDKIYFMAGSS 545
Cdd:COG0326 351 LDELEKLAKNdreKYE-KFWKEFGLVLKEGALEDFKNREKIADLLRFESTK-EGGYVTLAEYVERMKEGQKKIYYITGES 428
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   546 RKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESrEAVEKEFEPLLNWMKdK 625
Cdd:COG0326 429 REAAEQSPHLEIFKAKGIEVLLLTDPIDEFLISHLEEFDGKKFKSVDSGDLDLDKLEEKKES-EEEEEEFKPLLERFK-E 506
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   626 ALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQayqtGKDIStnyyaSQKKTFEINPRHPLIrdmlRRIKEDE 705
Cdd:COG0326 507 ALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKAM----GQDMP-----EAKPILEINPNHPLV----KKLAAEE 573
                       650       660       670       680
                ....*....|....*....|....*....|....*....|...
gi 119360   706 DDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLN 748
Cdd:COG0326 574 DEELFKDLAELLYDQALLAEGGLLEDPAAFVKRLNKLLEKALG 616
PTZ00272 PTZ00272
heat shock protein 83 kDa (Hsp83); Provisional
73-754 0e+00

heat shock protein 83 kDa (Hsp83); Provisional


Pssm-ID: 240341  Cd Length: 701  Bit Score: 650.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     73 SEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGV 152
Cdd:PTZ00272   2 TETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    153 GMTREELVKNLGTIAKSGTSEFLnkmtEAQEDGQSTSeLIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSN-EFS 231
Cdd:PTZ00272  82 GMTKADLVNNLGTIARSGTKAFM----EALEAGGDMS-MIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGgTFT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    232 VIADPRGNtLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKE--ESDDE 309
Cdd:PTZ00272 157 ITSTPESD-MKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDEEDTKKADEdgEEPKV 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    310 AAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFV 389
Cdd:PTZ00272 236 EEVKEGDEGKKKKTKKVKEVTKEYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEFRSIMFV 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    390 PTSAPRGLFDEygSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTL 469
Cdd:PTZ00272 316 PKRAPFDMFEP--NKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKCL 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    470 DMIKKIADDKYN-DTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKE 548
Cdd:PTZ00272 394 EMFDEVAENKEDyKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITGDSKKK 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    549 AESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDkALK 628
Cdd:PTZ00272 474 LETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKE-VLG 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    629 DKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYqtgKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDK 708
Cdd:PTZ00272 553 DKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQAL---RDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADENDK 629
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*.
gi 119360    709 TVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAK 754
Cdd:PTZ00272 630 AVKDLVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEEE 675
PTZ00130 PTZ00130
heat shock protein 90; Provisional
9-755 0e+00

heat shock protein 90; Provisional


Pssm-ID: 185466 [Multi-domain]  Cd Length: 814  Bit Score: 539.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360      9 LCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQirelreksekfaFQAEVNRMMKL 88
Cdd:PTZ00130  13 ICALQPNWVPQLCNVLCESDEGKSEEKEEKEEVKKDRDNIPEIEDGEKPTSGIEQHQ------------YQTEVTRLMDI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     89 IINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAK 168
Cdd:PTZ00130  81 IVNSLYTQKEVFLRELISNAADALEKIRFLSLSDESVLGEEKKLEIRISANKEKNILSITDTGIGMTKEDLINNLGTIAK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    169 SGTSEFLNKMTEAQEDgqstSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSN-EFSVIADPRGNTLGRGTTI 247
Cdd:PTZ00130 161 SGTSNFLEAISKSGGD----MSLIGQFGVGFYSAFLVADKVIVYTKNNNDEQYIWESTADaKFTIYKDPRGSTLKRGTRI 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    248 TLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKtetVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVE 327
Cdd:PTZ00130 237 SLHLKEDATNLMNDKKLVDLISKYSQFIQYPIYLLHEN---VYTEEVLADIAKEMENDPNYDSVKVEETDDPNKKTRTVE 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    328 KTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRglFDEYGSKKSD 407
Cdd:PTZ00130 314 KKVKKWKLMNEQKPIWLRPPKELTDEDYKKFFSVLSGFNDEPLYHIHFFAEGEIEFKCLIYIPSRAPS--INDHLFTKQN 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    408 YIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLD----------------- 470
Cdd:PTZ00130 392 SIKLYVRRVLVADEFVEFLPRYMSFVKGVVDSDDLPLNVSREQLQQNKILKAVSKRIVRKILDtfrtlykegkknketlr 471
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    471 --------------MIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDItSLDQYVERMKEKQD 536
Cdd:PTZ00130 472 aelaketdeekkkeIQKKINEPSTYKLIYKEYRKYLKTGCYEDDINRNKIVKLLLFKTMLHPKSI-SLDTYIENMKPDQK 550
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    537 KIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFE 616
Cdd:PTZ00130 551 FIYYASGDSYEYLSKIPQLQIFKKKNIDVVFLTESVDESCVQRVQEYDGKKFKSIQKGEITFELTEDEKKKEEKVKKMYK 630
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    617 PLLNWMKDkALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTnyyaSQKKTFEINPRHPLIRD 696
Cdd:PTZ00130 631 ALIDVISD-TLRNQIFKVEISRRLVDAPCAVVSTEWGLSGQMEKLMKINVNNSDQIKAM----SGQKILEINPDHPIMID 705
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119360    697 MLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKV 755
Cdd:PTZ00130 706 LLKRSVSNPKDSQLTESIKIIYQSAKLASGFDLEDTADLAQIVYDHINQKLGVDNNLKI 764
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
83-275 9.03e-99

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 304.06  E-value: 9.03e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    83 NRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKN 162
Cdd:cd16927   1 NQLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   163 LGTIAKSGTSEFLNKMTEAQEDgqstSELIGQFGVGFYSAFLVADKVIVTSKHN-NDTQHIWESDSNEFSVIADPRGNtL 241
Cdd:cd16927  81 LGTIARSGTKAFLEALQEGAKD----SDLIGQFGVGFYSAFMVADKVTVTTKSAgDDEGYRWESDGGGSYTIEEAEGE-L 155
                       170       180       190
                ....*....|....*....|....*....|....
gi 119360   242 GRGTTITLVLKEEASDYLELDTIKNLVKKYSQFI 275
Cdd:cd16927 156 GRGTKITLHLKEDAKEFLEEARIKELVKKYSDFI 189
PRK14083 PRK14083
HSP90 family protein; Provisional
77-464 1.09e-27

HSP90 family protein; Provisional


Pssm-ID: 237603 [Multi-domain]  Cd Length: 601  Bit Score: 118.89  E-value: 1.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     77 AFQAEVNRMMKLIINSLYKNKEIFLRELISNASDAldkIRLISLTDENAlsgNEELTVKIKCDKEKNLLhVTDTGVGMTR 156
Cdd:PRK14083   4 RFQVDLRGVIDLLSRHLYSSPRVYVRELLQNAVDA---ITARRALDPTA---PGRIRIELTDAGGGTLI-VEDNGIGLTE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    157 EELVKNLGTIAKSGTSEflnkmteaQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHI-W--ESDSNeFSVI 233
Cdd:PRK14083  77 EEVHEFLATIGRSSKRD--------ENLGFARNDFLGQFGIGLLSCFLVADEIVVVSRSAKDGPAVeWrgKADGT-YSVR 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    234 ADPrGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVwssktetveepmeeeeaakeekeesddeaave 313
Cdd:PRK14083 148 KLE-TERAEPGTTVYLRPRPDAEEWLERETVEELAKKYGSLLPVPIRV-------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360    314 eeeeekkpktkkvektVWDWELMNDIKPIWQR--PSKEVEEDEYKAFYKS-FSKEsddPMAYIHFTAEGEVTFkSILFV- 389
Cdd:PRK14083 195 ----------------EGEKGGVNETPPPWTRdyPDPETRREALLAYGEElLGFT---PLDVIPLDVPSGGLE-GVAYVl 254
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119360    390 PTSAPrglfdeYGSKKSDyiKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKL 464
Cdd:PRK14083 255 PYAVS------PAARRKH--RVYLKRMLLSEEAENLLPDWAFFVRCVVNTDELRPTASREALYEDDALAAVREEL 321
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
96-254 5.09e-09

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 54.58  E-value: 5.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360       96 NKEIFLRELISNASDaldkirlisltdeNAL---SGNEELTVKIKCDKEKNLLHVTDTGVGMTREElvknlgtiaksgts 172
Cdd:smart00387   1 GDPDRLRQVLSNLLD-------------NAIkytPEGGRITVTLERDGDHVEITVEDNGPGIPPED-------------- 53
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360      173 efLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNndtqhiwesdsnefsviadprgNTLGRGTTITLVLK 252
Cdd:smart00387  54 --LEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVELHGGEISVE----------------------SEPGGGTTFTITLP 109

                   ..
gi 119360      253 EE 254
Cdd:smart00387 110 LE 111
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
124-222 8.41e-06

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 46.17  E-value: 8.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360     124 NALSGNEElTVKIKCDKEKNL---LHVTDTGVGMTREELVKNLGtIAKSgtseflNKMTEAQEDGqstselIGQFGVGFY 200
Cdd:pfam13589  11 NSIDADAT-NIKIEVNKNRGGgteIVIEDDGHGMSPEELINALR-LATS------AKEAKRGSTD------LGRYGIGLK 76
                          90       100
                  ....*....|....*....|...
gi 119360     201 SAFLV-ADKVIVTSKHNNDTQHI 222
Cdd:pfam13589  77 LASLSlGAKLTVTSKKEGKSSTL 99
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
96-254 4.38e-05

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 43.13  E-value: 4.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360      96 NKEIFLRELISNASDALDKirlisltdenALSGNEELTVKIKCDkEKNLLHVTDTGVGMTREELvKNLGtiaksgtsefl 175
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALK----------HAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDL-PRIF----------- 57
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119360     176 nkmteaqeDGQSTSELIGQFGVGFysAFLVADKVIvtSKHNNDtqhIWesdsnefsviadpRGNTLGRGTTITLVLKEE 254
Cdd:pfam02518  58 --------EPFSTADKRGGGGTGL--GLSIVRKLV--ELLGGT---IT-------------VESEPGGGTTVTLTLPLA 108
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
101-217 5.37e-04

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 40.47  E-value: 5.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360   101 LRELISNASDAldkirlisltDENALsgnEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTiaksGTSeflnkmte 180
Cdd:cd16931  16 VAELVDNARDA----------DATRL---DIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISF----GFS-------- 70
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 119360   181 aqEDGQSTSELIGQFGVGFYS-AFLVADKVIVTSKHNN 217
Cdd:cd16931  71 --DKRSDDHDHIGRYGNGFKSgSMRLGRDVIVFTKKDE 106
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
125-165 1.92e-03

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 41.39  E-value: 1.92e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 119360   125 ALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELvKNLGT 165
Cdd:COG5806 326 AMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQL-ERLGE 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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