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Conserved domains on  [gi|1191704879|ref|NP_001238433|]
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uncharacterized protein LOC100306155 [Glycine max]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Biotinyl_lipoyl_domains super family cl11404
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 143-196 3.83e-04

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


The actual alignment was detected with superfamily member pfam01597:

Pssm-ID: 448245  Cd Length: 122  Bit Score: 38.85  E-value: 3.83e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191704879 143 VKGSLLEINQQLIKQPELLNVSAGREGYIAIIMPKPADWLKvkaSLVSLQEYKK 196
Cdd:pfam01597  67 VSGEVVEVNEKLEDNPGLINKDPYEDGWIAKLKPSNLEELE---SLMTAEQYEK 117
 
Name Accession Description Interval E-value
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 143-196 3.83e-04

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 38.85  E-value: 3.83e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191704879 143 VKGSLLEINQQLIKQPELLNVSAGREGYIAIIMPKPADWLKvkaSLVSLQEYKK 196
Cdd:pfam01597  67 VSGEVVEVNEKLEDNPGLINKDPYEDGWIAKLKPSNLEELE---SLMTAEQYEK 117
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 66-199 9.64e-04

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 37.89  E-value: 9.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191704879  66 QYVYRHANGLCVIGLapSHIAFNDEGGITAVDF-NVGKSDRSGikvtgkrkknaqhfESNTALCKISTKNDTYivrCCVK 144
Cdd:TIGR00527  13 EWVRVEGDKTATVGI--TKFAQDELGDIVFVELpEVGAEVAAG--------------ESLGSVESVKAASDIY---APVD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1191704879 145 GSLLEINQQLIKQPELLNVSAGREGYIAIImpKPADWLKVKASLVSLQEYKKSRE 199
Cdd:TIGR00527  74 GTVVEVNTALEDSPELVNEDPYGDGWLIKV--KLSDGESEVEGLMSAEQYEATLE 126
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 143-196 1.25e-03

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 37.41  E-value: 1.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191704879 143 VKGSLLEINQQLIKQPELLNVSAGREGYIAIImpKPADWLKVKAsLVSLQEYKK 196
Cdd:COG0509    73 VSGEVVEVNEALEDDPELVNEDPYGEGWLFKI--KPSDPAELDD-LLDAEAYAA 123
PRK01202 PRK01202
glycine cleavage system protein GcvH;
143-196 8.83e-03

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 35.13  E-value: 8.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191704879 143 VKGSLLEINQQLIKQPELLNVSAGREGYIAIIMPKPADWLKvkaSLVSLQEYKK 196
Cdd:PRK01202   73 VSGEVVEVNEALEDSPELVNEDPYGEGWLFKIKPSDESELD---DLLDAEAYEA 123
 
Name Accession Description Interval E-value
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 143-196 3.83e-04

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 38.85  E-value: 3.83e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191704879 143 VKGSLLEINQQLIKQPELLNVSAGREGYIAIIMPKPADWLKvkaSLVSLQEYKK 196
Cdd:pfam01597  67 VSGEVVEVNEKLEDNPGLINKDPYEDGWIAKLKPSNLEELE---SLMTAEQYEK 117
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 66-199 9.64e-04

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 37.89  E-value: 9.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191704879  66 QYVYRHANGLCVIGLapSHIAFNDEGGITAVDF-NVGKSDRSGikvtgkrkknaqhfESNTALCKISTKNDTYivrCCVK 144
Cdd:TIGR00527  13 EWVRVEGDKTATVGI--TKFAQDELGDIVFVELpEVGAEVAAG--------------ESLGSVESVKAASDIY---APVD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1191704879 145 GSLLEINQQLIKQPELLNVSAGREGYIAIImpKPADWLKVKASLVSLQEYKKSRE 199
Cdd:TIGR00527  74 GTVVEVNTALEDSPELVNEDPYGDGWLIKV--KLSDGESEVEGLMSAEQYEATLE 126
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 143-196 1.25e-03

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 37.41  E-value: 1.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191704879 143 VKGSLLEINQQLIKQPELLNVSAGREGYIAIImpKPADWLKVKAsLVSLQEYKK 196
Cdd:COG0509    73 VSGEVVEVNEALEDDPELVNEDPYGEGWLFKI--KPSDPAELDD-LLDAEAYAA 123
PRK01202 PRK01202
glycine cleavage system protein GcvH;
143-196 8.83e-03

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 35.13  E-value: 8.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191704879 143 VKGSLLEINQQLIKQPELLNVSAGREGYIAIIMPKPADWLKvkaSLVSLQEYKK 196
Cdd:PRK01202   73 VSGEVVEVNEALEDSPELVNEDPYGEGWLFKIKPSDESELD---DLLDAEAYEA 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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