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Conserved domains on  [gi|1190398948|ref|XP_020849566|]
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fibrocystin isoform X1 [Phascolarctos cinereus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1938-2056 4.45e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.57  E-value: 4.45e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1938 SWIPEGRPQDGDNVTVESGQTLLLDITTSVLRMLHIKgGKLMFTGPGPIELHAHCILVsHGGELRIGSQDKPYHGKALIH 2017
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILV-QGGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1190398948 2018 LHGS--SPSTIFFPYGAKFLAVRN-GTLSLHGLMPEVSFTYL 2056
Cdd:pfam10162   79 LHGRpeLDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKL 120
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2777-2900 1.11e-33

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 127.34  E-value: 1.11e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2777 WGGYNHttPAPGDDVMILPNRTILVDTDLPFLKGLYILGTLEFPVNRSNILNATCIIVAGGELKVGNFSEPLQkgQTLLI 2856
Cdd:pfam10162    2 WGGGVV--PQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPFQ--GKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1190398948 2857 QLQASAgvYCDRLDGINIAPGTIGV--YGKLQLHSAYPRKAWTHLG 2900
Cdd:pfam10162   78 TLHGRP--ELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1202-1300 7.22e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 78.27  E-value: 7.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1202 KVFQIEPCCGSLLGGTTLTISGIGFSKDPSLVSVSLGNQTCSIVNSTEETIWCETSSAPYLPDtepqavmVPIEVSIGni 1281
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGE-------GPVEVTVD-- 72

                           90
                   ....*....|....*....
gi 1190398948 1282 hapHDPSFDLGKKDFTFTY 1300
Cdd:cd00603     73 ---GANVSARVLSNTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 258-318 2.76e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 2.76e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1190398948  258 EILSVFPATGSLGGGTDITITGDFFDF---PAQVTVADIPCEIKYISPRKIECTTGPLKQGTKL 318
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSgspRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEG 65
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1394-1482 1.70e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.46  E-value: 1.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1394 PQVTNIFPTHGSVCGGTLLTIVGLVFKSRMSVVQVDLsGPHTCAIWNWNDRMILCQVSlvGHLPKASRGLNVTITVNGII 1473
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTP--AAATPGEGPVEVTVDGANVS 77


                   ....*....
gi 1190398948 1474 SKCQGNCTF 1482
Cdd:cd00603     78 ARVLSNTTF 86
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1113-1197 1.14e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 54.76  E-value: 1.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1113 PVIVSLSRNRSNTAGDQRLFIGTTSLvNYTDLDVKVRIQDTLTQILKQGPQGLEVALPPLPTGWHSISVTMNGVNIRSEG 1192
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSP 79


                   ....*
gi 1190398948 1193 VDLQI 1197
Cdd:pfam01833   80 LTFTY 84
NosD super family cl34609
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3031-3241 1.32e-08

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG3420:

Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 59.93  E-value: 1.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3031 SIEFNNVSL-GSWII-SSTVHQSCGGGIRVYSSKSIFLYDNILFDTiGHGIDLEGQNHSLIKNLIVLTRQPQRAVDWVtG 3108
Cdd:COG3420     74 TITADNVTVrGLTITgSGDSLTDDDAGIYVRGADNAVIENNRIENN-LFGIYLEGSDNNVIRNNTISGNRDLRADRGN-G 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3109 IKLNQVNDVNLTGNAVAGSeRIGFHI-RGHSCSVaenpwVGNVVHSSLHGLHLHKGDG--------LYNCTGIsgFLSY- 3178
Cdd:COG3420    152 IHLWNSPGNVIEGNTISGG-RDGIYLeFSDNNVI-----RNNTIRNLRYGIHYMYSNDnlvegntfRDNGAGI--ALMYs 223

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1190398948 3179 -----------KNFDYGAMFHAESNLEIDNVTLVDNVVGllplIYTSSAEHCSLKKKQIVlRNSI-IVATSSSFD 3241
Cdd:COG3420    224 kgntvrgntilGNSGYGILLKESSDSVIEGNTISGNGKG----IFIYNSNRNTIRGNLFA-GNGIgIHLTAGSEG 293
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1019-1109 2.54e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 54.00  E-value: 2.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1019 PKLEVVEPSVAPEIGGFWATIQGTSLEEVSL---VLFGSQPCPINisSRNMERIQCKVPPwigfQGNDSGRLVNVTIITR 1095
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVL--NVSSTEIVCRTPA----AATPGEGPVEVTVDGA 74

                           90
                   ....*....|....*.
gi 1190398948 1096 NLSLAY--PEAFEYTP 1109
Cdd:cd00603     75 NVSARVlsNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1577-1647 1.37e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 48.98  E-value: 1.37e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1190398948 1577 PQVLGYHPQNFSVNGGGLLTIEGTTLR-GKHTTSVLVGHQPCLTVNISSLFIQCIIPPG-NGTLVLEIEVDGN 1647
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGtDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGtSGLVNVSVTVGGG 73
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2247-2450 1.58e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


:

Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 50.87  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2247 GLSLSRTSNIIVENNVFYNILGHGLLVGtymemrhlpwkavprrktdfSGQGNIVRNNVVIGVFGTeglssievlspaGI 2326
Cdd:pfam13229    2 GILLNGSSNATIKNNTISNNGGYGIYLR--------------------GSSNATIENNTITNNGGD------------GI 49

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2327 YIQDPTNVVERNmvcaagygyffhlatsetskatllsfsqNVAHSCTRYGLLVYprfeppranDTGPTLFQNFTVWGSQG 2406
Cdd:pfam13229   50 EISGSSNNTISN----------------------------NTISNNGGGGIALR---------GSSNNLIENNTISNNGG 92

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1190398948 2407 -GVQIFRSSNLQLKNFQIYPCKDFGIDILESDANSSITDSLLLGH 2450
Cdd:pfam13229   93 aGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTNN 137
PA14 super family cl08459
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 357-480 2.82e-04

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


The actual alignment was detected with superfamily member pfam07691:

Pssm-ID: 471833 [Multi-domain]  Cd Length: 141  Bit Score: 43.90  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948  357 SSPFGFwSEAGQRFRARLSGFFVAPETNNYTFWIQADSPASLYFSQsedpgtkVKVafiqagiadwFDSWetnghleTWQ 436
Cdd:pfam07691   34 TDVPGF-GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWIDG-------ELV----------IDNW-------GQH 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1190398948  437 QKSL------KLKLSGGAKYYLEAEHYGITPSRGMSIGvqihntWLNPDV 480
Cdd:pfam07691   89 PPDAspeesnTLYLVAGKLYPIRIEYFHAGTGGSVQLS------WTSPDG 132
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1742-1797 3.00e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 39.75  E-value: 3.00e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1190398948 1742 TITSIYSNFGCL-GGRVLHVHGSGFSPG--NISAAVCGVPCQILdNATMTTFSCLVLPL 1797
Cdd:cd00603      2 VITSISPSSGPLsGGTRLTITGSNLGSGspRVRVTVGGVPCKVL-NVSSTEIVCRTPAA 59
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1496-1563 4.09e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 38.97  E-value: 4.09e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1190398948 1496 TTSVSGTLTTILIGGQKLATDTDELVVLVDDhLSCDITFYNATHVECQLSGLDPGLHHFSLLNKRKGF 1563
Cdd:pfam01833    9 SSGPASGGTTITITGSNFGTDSSDLKVTIGG-TPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGI 75
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1938-2056 4.45e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.57  E-value: 4.45e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1938 SWIPEGRPQDGDNVTVESGQTLLLDITTSVLRMLHIKgGKLMFTGPGPIELHAHCILVsHGGELRIGSQDKPYHGKALIH 2017
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILV-QGGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1190398948 2018 LHGS--SPSTIFFPYGAKFLAVRN-GTLSLHGLMPEVSFTYL 2056
Cdd:pfam10162   79 LHGRpeLDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKL 120
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2777-2900 1.11e-33

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 127.34  E-value: 1.11e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2777 WGGYNHttPAPGDDVMILPNRTILVDTDLPFLKGLYILGTLEFPVNRSNILNATCIIVAGGELKVGNFSEPLQkgQTLLI 2856
Cdd:pfam10162    2 WGGGVV--PQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPFQ--GKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1190398948 2857 QLQASAgvYCDRLDGINIAPGTIGV--YGKLQLHSAYPRKAWTHLG 2900
Cdd:pfam10162   78 TLHGRP--ELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1202-1300 7.22e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 78.27  E-value: 7.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1202 KVFQIEPCCGSLLGGTTLTISGIGFSKDPSLVSVSLGNQTCSIVNSTEETIWCETSSAPYLPDtepqavmVPIEVSIGni 1281
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGE-------GPVEVTVD-- 72

                           90
                   ....*....|....*....
gi 1190398948 1282 hapHDPSFDLGKKDFTFTY 1300
Cdd:cd00603     73 ---GANVSARVLSNTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 258-318 2.76e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 2.76e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1190398948  258 EILSVFPATGSLGGGTDITITGDFFDF---PAQVTVADIPCEIKYISPRKIECTTGPLKQGTKL 318
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSgspRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEG 65
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1394-1482 1.70e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.46  E-value: 1.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1394 PQVTNIFPTHGSVCGGTLLTIVGLVFKSRMSVVQVDLsGPHTCAIWNWNDRMILCQVSlvGHLPKASRGLNVTITVNGII 1473
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTP--AAATPGEGPVEVTVDGANVS 77


                   ....*....
gi 1190398948 1474 SKCQGNCTF 1482
Cdd:cd00603     78 ARVLSNTTF 86
IPT smart00429
ig-like, plexins, transcription factors;
1202-1301 7.17e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 55.50  E-value: 7.17e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948  1202 KVFQIEPCCGSLLGGTTLTISGIGFSKDPSL-VSVSLGNQTCSIVNSTEETIWCETSSAPYLPDTepqavmVPI-EVSIG 1279
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVfVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGS------VPVrTVGLR 76

                            90       100
                    ....*....|....*....|..
gi 1190398948  1280 NIHAPHDPSfdlgkkdfTFTYH 1301
Cdd:smart00429   77 NGGVPSSPQ--------PFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1113-1197 1.14e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 54.76  E-value: 1.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1113 PVIVSLSRNRSNTAGDQRLFIGTTSLvNYTDLDVKVRIQDTLTQILKQGPQGLEVALPPLPTGWHSISVTMNGVNIRSEG 1192
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSP 79


                   ....*
gi 1190398948 1193 VDLQI 1197
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 259-316 1.26e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 54.76  E-value: 1.26e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1190398948  259 ILSVFPATGSLGGGTDITITGDFFDFP---AQVTVADIPCEIKYISPRKIECTTGPLKQGT 316
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDssdLKVTIGGTPCTVISVSSTTIVCTTPPGTSGL 63
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3031-3241 1.32e-08

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 59.93  E-value: 1.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3031 SIEFNNVSL-GSWII-SSTVHQSCGGGIRVYSSKSIFLYDNILFDTiGHGIDLEGQNHSLIKNLIVLTRQPQRAVDWVtG 3108
Cdd:COG3420     74 TITADNVTVrGLTITgSGDSLTDDDAGIYVRGADNAVIENNRIENN-LFGIYLEGSDNNVIRNNTISGNRDLRADRGN-G 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3109 IKLNQVNDVNLTGNAVAGSeRIGFHI-RGHSCSVaenpwVGNVVHSSLHGLHLHKGDG--------LYNCTGIsgFLSY- 3178
Cdd:COG3420    152 IHLWNSPGNVIEGNTISGG-RDGIYLeFSDNNVI-----RNNTIRNLRYGIHYMYSNDnlvegntfRDNGAGI--ALMYs 223

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1190398948 3179 -----------KNFDYGAMFHAESNLEIDNVTLVDNVVGllplIYTSSAEHCSLKKKQIVlRNSI-IVATSSSFD 3241
Cdd:COG3420    224 kgntvrgntilGNSGYGILLKESSDSVIEGNTISGNGKG----IFIYNSNRNTIRGNLFA-GNGIgIHLTAGSEG 293
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1019-1109 2.54e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 54.00  E-value: 2.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1019 PKLEVVEPSVAPEIGGFWATIQGTSLEEVSL---VLFGSQPCPINisSRNMERIQCKVPPwigfQGNDSGRLVNVTIITR 1095
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVL--NVSSTEIVCRTPA----AATPGEGPVEVTVDGA 74

                           90
                   ....*....|....*.
gi 1190398948 1096 NLSLAY--PEAFEYTP 1109
Cdd:cd00603     75 NVSARVlsNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1394-1482 1.07e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.06  E-value: 1.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1394 PQVTNIFPTHGSVCGGTLLTIVGLVFKSRMSVVQVDLSGPhTCAIWNWNDRMILCQVslvghlPKASRGL-NVTITVNGi 1472
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTT------PPGTSGLvNVSVTVGG- 72

                           90
                   ....*....|
gi 1190398948 1473 ISKCQGNCTF 1482
Cdd:pfam01833   73 GGISSSPLTF 82
IPT smart00429
ig-like, plexins, transcription factors;
258-316 4.67e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.50  E-value: 4.67e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1190398948   258 EILSVFPATGSLGGGTDITITGDFFDFPA----QVTVADIPCEIKYISPRKIECTTGPLKQGT 316
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISvvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIP 65
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1206-1300 1.18e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 48.98  E-value: 1.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1206 IEPCCGSLLGGTTLTISGIGFSKDPSLVSVSLGNQTCSIVNSTEETIWCETSSAPylpdtepqAVMVPIEVSIGNIHAPH 1285
Cdd:pfam01833    6 ISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT--------SGLVNVSVTVGGGGISS 77

                           90
                   ....*....|....*
gi 1190398948 1286 DPsfdlgkkdFTFTY 1300
Cdd:pfam01833   78 SP--------LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1577-1647 1.37e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 48.98  E-value: 1.37e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1190398948 1577 PQVLGYHPQNFSVNGGGLLTIEGTTLR-GKHTTSVLVGHQPCLTVNISSLFIQCIIPPG-NGTLVLEIEVDGN 1647
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGtDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGtSGLVNVSVTVGGG 73
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2247-2450 1.58e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 50.87  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2247 GLSLSRTSNIIVENNVFYNILGHGLLVGtymemrhlpwkavprrktdfSGQGNIVRNNVVIGVFGTeglssievlspaGI 2326
Cdd:pfam13229    2 GILLNGSSNATIKNNTISNNGGYGIYLR--------------------GSSNATIENNTITNNGGD------------GI 49

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2327 YIQDPTNVVERNmvcaagygyffhlatsetskatllsfsqNVAHSCTRYGLLVYprfeppranDTGPTLFQNFTVWGSQG 2406
Cdd:pfam13229   50 EISGSSNNTISN----------------------------NTISNNGGGGIALR---------GSSNNLIENNTISNNGG 92

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1190398948 2407 -GVQIFRSSNLQLKNFQIYPCKDFGIDILESDANSSITDSLLLGH 2450
Cdd:pfam13229   93 aGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTNN 137
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3032-3205 5.72e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 49.33  E-value: 5.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3032 IEFNNVSLGSwIISSTVHQSCGGGIRVYSSKSIFLYDNILFDTIGHGIDLEGQNHSLIKNLIVLTRqpqravdWVTGIKL 3111
Cdd:pfam13229    3 ILLNGSSNAT-IKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNN-------GGGGIAL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3112 NQVNDVNLTGNAVAGSERIGFHIRG------HSCSVAENPWVGNVVHSSLHGLHLHkgdglyNCTgISGflsykNFDYGA 3185
Cdd:pfam13229   75 RGSSNNLIENNTISNNGGAGIYLSDssnntiENNIIHNNGGSGIVIEDSSNNVTIS------NNT-VTN-----NKGAGI 142

                          170       180
                   ....*....|....*....|
gi 1190398948 3186 MFHAESNleidNVTLVDNVV 3205
Cdd:pfam13229  143 LIVGGSS----NNTVENNTF 158
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1577-1666 5.72e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 47.45  E-value: 5.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1577 PQVLGYHPQNFSVNGGGLLTIEGTTL-RGKHTTSVLVGHQPCLTVNISSLFIQCIIPPGNGTLVLEIEVdgnlyDVGMIG 1655
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLgSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEV-----TVDGAN 75

                           90
                   ....*....|.
gi 1190398948 1656 YSDAFTPALLF 1666
Cdd:cd00603     76 VSARVLSNTTF 86
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 357-480 2.82e-04

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 43.90  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948  357 SSPFGFwSEAGQRFRARLSGFFVAPETNNYTFWIQADSPASLYFSQsedpgtkVKVafiqagiadwFDSWetnghleTWQ 436
Cdd:pfam07691   34 TDVPGF-GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWIDG-------ELV----------IDNW-------GQH 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1190398948  437 QKSL------KLKLSGGAKYYLEAEHYGITPSRGMSIGvqihntWLNPDV 480
Cdd:pfam07691   89 PPDAspeesnTLYLVAGKLYPIRIEYFHAGTGGSVQLS------WTSPDG 132
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1742-1797 3.00e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 39.75  E-value: 3.00e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1190398948 1742 TITSIYSNFGCL-GGRVLHVHGSGFSPG--NISAAVCGVPCQILdNATMTTFSCLVLPL 1797
Cdd:cd00603      2 VITSISPSSGPLsGGTRLTITGSNLGSGspRVRVTVGGVPCKVL-NVSSTEIVCRTPAA 59
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1496-1563 4.09e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 38.97  E-value: 4.09e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1190398948 1496 TTSVSGTLTTILIGGQKLATDTDELVVLVDDhLSCDITFYNATHVECQLSGLDPGLHHFSLLNKRKGF 1563
Cdd:pfam01833    9 SSGPASGGTTITITGSNFGTDSSDLKVTIGG-TPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGI 75
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 1938-2056 4.45e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.57  E-value: 4.45e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1938 SWIPEGRPQDGDNVTVESGQTLLLDITTSVLRMLHIKgGKLMFTGPGPIELHAHCILVsHGGELRIGSQDKPYHGKALIH 2017
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFDDDKNITLRARYILV-QGGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1190398948 2018 LHGS--SPSTIFFPYGAKFLAVRN-GTLSLHGLMPEVSFTYL 2056
Cdd:pfam10162   79 LHGRpeLDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKL 120
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2777-2900 1.11e-33

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 127.34  E-value: 1.11e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2777 WGGYNHttPAPGDDVMILPNRTILVDTDLPFLKGLYILGTLEFPVNRSNILNATCIIVAGGELKVGNFSEPLQkgQTLLI 2856
Cdd:pfam10162    2 WGGGVV--PQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNITLRARYILVQGGRLIIGSEDCPFQ--GKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1190398948 2857 QLQASAgvYCDRLDGINIAPGTIGV--YGKLQLHSAYPRKAWTHLG 2900
Cdd:pfam10162   78 TLHGRP--ELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1202-1300 7.22e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 78.27  E-value: 7.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1202 KVFQIEPCCGSLLGGTTLTISGIGFSKDPSLVSVSLGNQTCSIVNSTEETIWCETSSAPYLPDtepqavmVPIEVSIGni 1281
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGE-------GPVEVTVD-- 72

                           90
                   ....*....|....*....
gi 1190398948 1282 hapHDPSFDLGKKDFTFTY 1300
Cdd:cd00603     73 ---GANVSARVLSNTTFTY 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1202-1302 2.75e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 68.26  E-value: 2.75e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1202 KVFQIEPCCGSLLGGTTLTISGIGFSKDPSL-VSVSlGNQTCSIVNSTEETIWCETSSAPYLPDtepqavmVPIEVSIGN 1280
Cdd:cd00102      2 VITSISPSSGPVSGGTEVTITGSNFGSGSNLrVTFG-GGVPCSVLSVSSTAIVCTTPPYANPGP-------GPVEVTVDR 73

                           90       100
                   ....*....|....*....|..
gi 1190398948 1281 ihaphdPSFDLGKKDFTFTYHT 1302
Cdd:cd00102     74 ------GNGGITSSPLTFTYVP 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 258-318 2.76e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 65.17  E-value: 2.76e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1190398948  258 EILSVFPATGSLGGGTDITITGDFFDF---PAQVTVADIPCEIKYISPRKIECTTGPLKQGTKL 318
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSgspRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEG 65
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 258-315 1.21e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 57.86  E-value: 1.21e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1190398948  258 EILSVFPATGSLGGGTDITITGDFFDFPAQVTV---ADIPCEIKYISPRKIECTTGPLKQG 315
Cdd:cd00102      2 VITSISPSSGPVSGGTEVTITGSNFGSGSNLRVtfgGGVPCSVLSVSSTAIVCTTPPYANP 62
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1394-1482 1.70e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.46  E-value: 1.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1394 PQVTNIFPTHGSVCGGTLLTIVGLVFKSRMSVVQVDLsGPHTCAIWNWNDRMILCQVSlvGHLPKASRGLNVTITVNGII 1473
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTV-GGVPCKVLNVSSTEIVCRTP--AAATPGEGPVEVTVDGANVS 77


                   ....*....
gi 1190398948 1474 SKCQGNCTF 1482
Cdd:cd00603     78 ARVLSNTTF 86
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 258-311 6.35e-09

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 55.78  E-value: 6.35e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1190398948  258 EILSVFPATGSLGGGTDITITGDFFDFPA-----QVTVADIPCEI---KYISPRKIECTTGP 311
Cdd:cd01180      2 VITEFFPLSGPLEGGTRLTICGSNLGLRKndvrhGVRVGGVPCNPeppEYSSSEKIVCTTGP 63
IPT smart00429
ig-like, plexins, transcription factors;
1202-1301 7.17e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 55.50  E-value: 7.17e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948  1202 KVFQIEPCCGSLLGGTTLTISGIGFSKDPSL-VSVSLGNQTCSIVNSTEETIWCETSSAPYLPDTepqavmVPI-EVSIG 1279
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISVVfVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGS------VPVrTVGLR 76

                            90       100
                    ....*....|....*....|..
gi 1190398948  1280 NIHAPHDPSfdlgkkdfTFTYH 1301
Cdd:smart00429   77 NGGVPSSPQ--------PFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1113-1197 1.14e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 54.76  E-value: 1.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1113 PVIVSLSRNRSNTAGDQRLFIGTTSLvNYTDLDVKVRIQDTLTQILKQGPQGLEVALPPLPTGWHSISVTMNGVNIRSEG 1192
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNF-GTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSP 79


                   ....*
gi 1190398948 1193 VDLQI 1197
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 259-316 1.26e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 54.76  E-value: 1.26e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1190398948  259 ILSVFPATGSLGGGTDITITGDFFDFP---AQVTVADIPCEIKYISPRKIECTTGPLKQGT 316
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDssdLKVTIGGTPCTVISVSSTTIVCTTPPGTSGL 63
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3031-3241 1.32e-08

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 59.93  E-value: 1.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3031 SIEFNNVSL-GSWII-SSTVHQSCGGGIRVYSSKSIFLYDNILFDTiGHGIDLEGQNHSLIKNLIVLTRQPQRAVDWVtG 3108
Cdd:COG3420     74 TITADNVTVrGLTITgSGDSLTDDDAGIYVRGADNAVIENNRIENN-LFGIYLEGSDNNVIRNNTISGNRDLRADRGN-G 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3109 IKLNQVNDVNLTGNAVAGSeRIGFHI-RGHSCSVaenpwVGNVVHSSLHGLHLHKGDG--------LYNCTGIsgFLSY- 3178
Cdd:COG3420    152 IHLWNSPGNVIEGNTISGG-RDGIYLeFSDNNVI-----RNNTIRNLRYGIHYMYSNDnlvegntfRDNGAGI--ALMYs 223

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1190398948 3179 -----------KNFDYGAMFHAESNLEIDNVTLVDNVVGllplIYTSSAEHCSLKKKQIVlRNSI-IVATSSSFD 3241
Cdd:COG3420    224 kgntvrgntilGNSGYGILLKESSDSVIEGNTISGNGKG----IFIYNSNRNTIRGNLFA-GNGIgIHLTAGSEG 293
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1394-1477 2.30e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 54.00  E-value: 2.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1394 PQVTNIFPTHGSVCGGTLLTIVGLVFKSRMSvVQVDLSGPHTCAIWNWNDRMILCQVSLVGHLPKASRGLNVTITVNGII 1473
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN-LRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRGNGGIT 79


                   ....
gi 1190398948 1474 SKCQ 1477
Cdd:cd00102     80 SSPL 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1019-1109 2.54e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 54.00  E-value: 2.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1019 PKLEVVEPSVAPEIGGFWATIQGTSLEEVSL---VLFGSQPCPINisSRNMERIQCKVPPwigfQGNDSGRLVNVTIITR 1095
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrvrVTVGGVPCKVL--NVSSTEIVCRTPA----AATPGEGPVEVTVDGA 74

                           90
                   ....*....|....*.
gi 1190398948 1096 NLSLAY--PEAFEYTP 1109
Cdd:cd00603     75 NVSARVlsNTTFTYVE 90
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1202-1298 5.27e-08

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 53.09  E-value: 5.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1202 KVFQIEPCCGSLLGGTTLTISGI--GFSKDPSLVSVSLGNQTCSIVN---STEETIWCETSSAPYLPDTepqavmVPIEV 1276
Cdd:cd01180      2 VITEFFPLSGPLEGGTRLTICGSnlGLRKNDVRHGVRVGGVPCNPEPpeySSSEKIVCTTGPAGNPVFN------GPVEV 75

                           90       100
                   ....*....|....*....|..
gi 1190398948 1277 SIGnihapHDPSFDLGKKDFTF 1298
Cdd:cd01180     76 TVG-----HGSFRTESSEGFSF 92
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1394-1482 1.07e-07

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.06  E-value: 1.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1394 PQVTNIFPTHGSVCGGTLLTIVGLVFKSRMSVVQVDLSGPhTCAIWNWNDRMILCQVslvghlPKASRGL-NVTITVNGi 1472
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGT-PCTVISVSSTTIVCTT------PPGTSGLvNVSVTVGG- 72

                           90
                   ....*....|
gi 1190398948 1473 ISKCQGNCTF 1482
Cdd:pfam01833   73 GGISSSPLTF 82
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 259-311 2.15e-07

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 51.07  E-value: 2.15e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1190398948  259 ILSVFPATGSLGGGTDITITGDFFD--FPAQVTVADIPCEIKYISPRKIECTTGP 311
Cdd:cd01179      3 ITSLSPSYGPQSGGTRLTITGKHLNagSSVRVTVGGQPCKILSVSSSQIVCLTPP 57
IPT smart00429
ig-like, plexins, transcription factors;
258-316 4.67e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.50  E-value: 4.67e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1190398948   258 EILSVFPATGSLGGGTDITITGDFFDFPA----QVTVADIPCEIKYISPRKIECTTGPLKQGT 316
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSISvvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIP 65
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1206-1300 1.18e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 48.98  E-value: 1.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1206 IEPCCGSLLGGTTLTISGIGFSKDPSLVSVSLGNQTCSIVNSTEETIWCETSSAPylpdtepqAVMVPIEVSIGNIHAPH 1285
Cdd:pfam01833    6 ISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT--------SGLVNVSVTVGGGGISS 77

                           90
                   ....*....|....*
gi 1190398948 1286 DPsfdlgkkdFTFTY 1300
Cdd:pfam01833   78 SP--------LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1577-1647 1.37e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 48.98  E-value: 1.37e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1190398948 1577 PQVLGYHPQNFSVNGGGLLTIEGTTLR-GKHTTSVLVGHQPCLTVNISSLFIQCIIPPG-NGTLVLEIEVDGN 1647
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGtDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGtSGLVNVSVTVGGG 73
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2247-2450 1.58e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 50.87  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2247 GLSLSRTSNIIVENNVFYNILGHGLLVGtymemrhlpwkavprrktdfSGQGNIVRNNVVIGVFGTeglssievlspaGI 2326
Cdd:pfam13229    2 GILLNGSSNATIKNNTISNNGGYGIYLR--------------------GSSNATIENNTITNNGGD------------GI 49

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2327 YIQDPTNVVERNmvcaagygyffhlatsetskatllsfsqNVAHSCTRYGLLVYprfeppranDTGPTLFQNFTVWGSQG 2406
Cdd:pfam13229   50 EISGSSNNTISN----------------------------NTISNNGGGGIALR---------GSSNNLIENNTISNNGG 92

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1190398948 2407 -GVQIFRSSNLQLKNFQIYPCKDFGIDILESDANSSITDSLLLGH 2450
Cdd:pfam13229   93 aGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNNVTISNNTVTNN 137
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1202-1301 4.48e-06

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 47.60  E-value: 4.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1202 KVFQIEPCCGSLLGGTTLTISG----IGfskdpSLVSVSLGNQTCSIVNSTEETIWCETSSAPYLPDtepqavmVPIEVS 1277
Cdd:cd01179      2 SITSLSPSYGPQSGGTRLTITGkhlnAG-----SSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGE-------APVKVL 69

                           90       100
                   ....*....|....*....|....
gi 1190398948 1278 IGniHAPHDPsfdlgkkDFTFTYH 1301
Cdd:cd01179     70 ID--GARRLA-------PLVFTYT 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1019-1109 4.61e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 47.46  E-value: 4.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1019 PKLEVVEPSVAPEIGGFWATIQGTSLEEVSLV---LFGSQPCPINisSRNMERIQCKVPPwigfQGNDSGRLVNVTIITR 1095
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLrvtFGGGVPCSVL--SVSSTAIVCTTPP----YANPGPGPVEVTVDRG 74

                           90
                   ....*....|....*
gi 1190398948 1096 NLSLAY-PEAFEYTP 1109
Cdd:cd00102     75 NGGITSsPLTFTYVP 89
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3032-3205 5.72e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 49.33  E-value: 5.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3032 IEFNNVSLGSwIISSTVHQSCGGGIRVYSSKSIFLYDNILFDTIGHGIDLEGQNHSLIKNLIVLTRqpqravdWVTGIKL 3111
Cdd:pfam13229    3 ILLNGSSNAT-IKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNN-------GGGGIAL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3112 NQVNDVNLTGNAVAGSERIGFHIRG------HSCSVAENPWVGNVVHSSLHGLHLHkgdglyNCTgISGflsykNFDYGA 3185
Cdd:pfam13229   75 RGSSNNLIENNTISNNGGAGIYLSDssnntiENNIIHNNGGSGIVIEDSSNNVTIS------NNT-VTN-----NKGAGI 142

                          170       180
                   ....*....|....*....|
gi 1190398948 3186 MFHAESNleidNVTLVDNVV 3205
Cdd:pfam13229  143 LIVGGSS----NNTVENNTF 158
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1577-1666 5.72e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 47.45  E-value: 5.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1577 PQVLGYHPQNFSVNGGGLLTIEGTTL-RGKHTTSVLVGHQPCLTVNISSLFIQCIIPPGNGTLVLEIEVdgnlyDVGMIG 1655
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLgSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEV-----TVDGAN 75

                           90
                   ....*....|.
gi 1190398948 1656 YSDAFTPALLF 1666
Cdd:cd00603     76 VSARVLSNTTF 86
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1019-1075 6.19e-06

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 47.22  E-value: 6.19e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1019 PKLEVVEPSVAPEIGGFWATIQGTSL---EEVSlVLFGSQPCPinISSRNMERIQCKVPP 1075
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLnagSSVR-VTVGGQPCK--ILSVSSSQIVCLTPP 57
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3011-3144 9.95e-06

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 48.56  E-value: 9.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3011 SGTLQISNVEIQNFGsllYPSIEFNNVSlGSWIISSTVHQSCGGGIRVYSSKSIFLYDNILFDTIGHGIDLEGQNHSLIK 3090
Cdd:pfam13229   31 SSNATIENNTITNNG---GDGIEISGSS-NNTISNNTISNNGGGGIALRGSSNNLIENNTISNNGGAGIYLSDSSNNTIE 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1190398948 3091 NLIVLTRQpqravdwVTGIKL-NQVNDVNLTGNAVAGSERIGFHIRGHS--CSVAEN 3144
Cdd:pfam13229  107 NNIIHNNG-------GSGIVIeDSSNNVTISNNTVTNNKGAGILIVGGSsnNTVENN 156
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1203-1302 1.09e-04

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 43.94  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1203 VFQIEPCCGSLLGGTTLTISGIGFS--KDPSLVsVSLGNQ---TCSIVNSTeeTIWCETSSAPYLPDTEPQAvMVPIEVS 1277
Cdd:cd01181      3 ITRIEPEWSFLSGGTPITVTGTNLNtvQEPRIR-VKYGGVektSCKVRNST--LMTCPAPSLALLNRSPEPG-ERPVEFG 78

                           90       100
                   ....*....|....*....|....*
gi 1190398948 1278 IGNIHAphdPSFDLGkKDFTFTYHT 1302
Cdd:cd01181     79 LDGDNV---QSLLIL-NRTSFSYYP 99
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2235-2380 1.97e-04

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 44.71  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2235 IRSCSVRDSFSRGLSLSRTSNIIVENNVFYNILGHGLLV--GTYMEMRHlpwkavprrktdfsgqgNIVRNNVVIGVFGT 2312
Cdd:pfam13229   13 IKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEIsgSSNNTISN-----------------NTISNNGGGGIALR 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1190398948 2313 EGLSS------IEVLSPAGIYIQDPTNVVERNMVCAAGYGYFFHLATSETSkatlLSFSQNVAHSCTRYGLLVY 2380
Cdd:pfam13229   76 GSSNNlienntISNNGGAGIYLSDSSNNTIENNIIHNNGGSGIVIEDSSNN----VTISNNTVTNNKGAGILIV 145
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 357-480 2.82e-04

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 43.90  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948  357 SSPFGFwSEAGQRFRARLSGFFVAPETNNYTFWIQADSPASLYFSQsedpgtkVKVafiqagiadwFDSWetnghleTWQ 436
Cdd:pfam07691   34 TDVPGF-GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWIDG-------ELV----------IDNW-------GQH 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1190398948  437 QKSL------KLKLSGGAKYYLEAEHYGITPSRGMSIGvqihntWLNPDV 480
Cdd:pfam07691   89 PPDAspeesnTLYLVAGKLYPIRIEYFHAGTGGSVQLS------WTSPDG 132
NosD pfam05048
Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to ...
 3017-3152 7.38e-04

Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ). This region forms a parallel beta helix domain.


Pssm-ID: 428281 [Multi-domain]  Cd Length: 215  Bit Score: 43.95  E-value: 7.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3017 SNVEI-QNFGSLLYPSIEFNNvsLGSWIISSTVHQSCGGGIRVYSSKSIFLYDNILFDTIGHGIDLEGQNHSLIKNLIVL 3095
Cdd:pfam05048   50 NNNTItGNRISNLRYGIHLMN--SNDNTISDNVFSGNTAGIALMSSSNNTLENNTISGNTNYGILLSDSSNNTISNNTIS 127

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1190398948 3096 TRQpqravdwVTGIKLNQVNDVNLTGNAVAGSErIGFHIRGHSCS--VAENPWVGNVVH 3152
Cdd:pfam05048  128 NNN-------GKGIFLYNSDYNTITGNRITSNG-IGIHFLAGSNGntIYNNYFINNSEN 178
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1577-1661 9.29e-04

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 40.91  E-value: 9.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 1577 PQVLGYHPQNFSVNGGGLLTIEGTTLRGKHTTSVLV-GHQPCLTVNISSLFIQCIIPPGNGTLVLEIEVDGNLYDVGMIG 1655
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRGNGGITS 80


                   ....*.
gi 1190398948 1656 YSDAFT 1661
Cdd:cd00102     81 SPLTFT 86
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1591-1646 1.40e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 40.29  E-value: 1.40e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1190398948 1591 GGGLLTIEGTTLRGKHTTSVLVGHQPCLTVNISSLFIQCIIPPGN--GTLVLEIEVDG 1646
Cdd:cd01179     15 GGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAspGEAPVKVLIDG 72
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 2231-2338 2.40e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 41.62  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 2231 KDSFIRSCSVRDSFSRGLSLSRTSNIIVENNVFYNILGHGLLVgtymemrhlpwkavprrktDFSGQGNIVRNNVVIGVF 2310
Cdd:pfam13229   78 SNNLIENNTISNNGGAGIYLSDSSNNTIENNIIHNNGGSGIVI-------------------EDSSNNVTISNNTVTNNK 138

                           90       100       110
                   ....*....|....*....|....*....|
gi 1190398948 2311 GteglssievlspAGIYI--QDPTNVVERN 2338
Cdd:pfam13229  139 G------------AGILIvgGSSNNTVENN 156
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1742-1797 3.00e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 39.75  E-value: 3.00e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1190398948 1742 TITSIYSNFGCL-GGRVLHVHGSGFSPG--NISAAVCGVPCQILdNATMTTFSCLVLPL 1797
Cdd:cd00603      2 VITSISPSSGPLsGGTRLTITGSNLGSGspRVRVTVGGVPCKVL-NVSSTEIVCRTPAA 59
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1496-1563 4.09e-03

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 38.97  E-value: 4.09e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1190398948 1496 TTSVSGTLTTILIGGQKLATDTDELVVLVDDhLSCDITFYNATHVECQLSGLDPGLHHFSLLNKRKGF 1563
Cdd:pfam01833    9 SSGPASGGTTITITGSNFGTDSSDLKVTIGG-TPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGI 75
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3054-3217 4.74e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.85  E-value: 4.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3054 GGIRVYSSKSIFLYDNILFDTIGHGIDLEGQNHSLIKNLIVLTRQpqravdwVTGIKLNQVNDVNLTGNAVAGSERIGFH 3133
Cdd:pfam13229    1 SGILLNGSSNATIKNNTISNNGGYGIYLRGSSNATIENNTITNNG-------GDGIEISGSSNNTISNNTISNNGGGGIA 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3134 IRGHSCSVAENpwvgNVVHSSL-HGLHLHKGDG--LYNCTgisgflSYKNFDYG-AMFHAESNLEIDNVTLVDNV-VGLl 3208
Cdd:pfam13229   74 LRGSSNNLIEN----NTISNNGgAGIYLSDSSNntIENNI------IHNNGGSGiVIEDSSNNVTISNNTVTNNKgAGI- 142


                   ....*....
gi 1190398948 3209 pLIYTSSAE 3217
Cdd:pfam13229  143 -LIVGGSSN 150
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3053-3152 9.19e-03

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 41.44  E-value: 9.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190398948 3053 GGGIRVYSSKSIFLYDNILFDTIGHGIDLEGQNHSLIKNLIVltrqpqraVDWVTGIKLNQVNDVNLTGNAVAGSErIGF 3132
Cdd:COG3420    215 GAGIALMYSKGNTVRGNTILGNSGYGILLKESSDSVIEGNTI--------SGNGKGIFIYNSNRNTIRGNLFAGNG-IGI 285

                           90       100
                   ....*....|....*....|..
gi 1190398948 3133 HIRGHSCS--VAENPWVGNVVH 3152
Cdd:COG3420    286 HLTAGSEGnrIYGNNFIGNRTQ 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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