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Conserved domains on  [gi|1187837493|gb|ARM55339|]
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olfactory receptor family 5, partial [Vampyrum spectrum]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 1-118 2.16e-65

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15413:

Pssm-ID: 475119  Cd Length: 279  Bit Score: 199.09  E-value: 2.16e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15413   141 RLSFCGSNVINHFYCDDLPLLALSCSDTHEKELIILIFAGFNLISSLLIVLVSYlfilsAILRIRSAEGRQKAFSTCGSH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15413   221 LTVVTIFYGTLIFMYLQPKSSHSLDTDKMASVFYTLVIPMLNP 263
 
Name Accession Description Interval E-value
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 1-118 2.16e-65

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 199.09  E-value: 2.16e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15413   141 RLSFCGSNVINHFYCDDLPLLALSCSDTHEKELIILIFAGFNLISSLLIVLVSYlfilsAILRIRSAEGRQKAFSTCGSH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15413   221 LTVVTIFYGTLIFMYLQPKSSHSLDTDKMASVFYTLVIPMLNP 263
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 5-119 5.25e-11

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 57.51  E-value: 5.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   5 CDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHLTSI 79
Cdd:pfam13853 139 CGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLIVLSYglilrTVLGIASREGRLKALNTCGSHVCAV 218

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  80 TIFYGTIIFMYLLPKSSHSLN--TDKFASVFYVVAIPMLNPV 119
Cdd:pfam13853 219 LAFYTPMIGLSMVHRFGHNVPplLQIMMANAYLFFPPVLNPI 260
 
Name Accession Description Interval E-value
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 1-118 2.16e-65

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 199.09  E-value: 2.16e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15413   141 RLSFCGSNVINHFYCDDLPLLALSCSDTHEKELIILIFAGFNLISSLLIVLVSYlfilsAILRIRSAEGRQKAFSTCGSH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15413   221 LTVVTIFYGTLIFMYLQPKSSHSLDTDKMASVFYTLVIPMLNP 263
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 1-118 2.57e-59

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 183.09  E-value: 2.57e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15230   141 SLSFCGSNVINHFFCDIPPLLKLSCSDTHINELVLFAFSGFIGLSTLLIILISYlyiliTILRIRSAEGRRKAFSTCASH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15230   221 LTAVSLFYGTLIFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNP 263
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 2-119 5.66e-54

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 170.53  E-value: 5.66e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15410   155 LSFCGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYvfiivTILRIRSAEGRQKAFSTCASHL 234

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15410   235 TAITIFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 1-119 1.26e-52

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 166.12  E-value: 1.26e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd13954   141 QLPFCGSNVINHFFCDIPPLLKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYiyiisTILKIPSAEGRQKAFSTCASH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd13954   221 LTVVSLFYGTIIFMYVRPSSSYSSDLDKVVSVFYTVVTPMLNPI 264
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 1-119 2.90e-52

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 165.67  E-value: 2.90e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15407   141 RLSFCKSNVINHFFCDIPPVLALSCSDIHISEIVLFFLASFNVFFALLVILISYlfifiTILRMRSAEGHQKAFSTCASH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15407   221 LTAVSIFYGTVIFMYLQPSSSHSMDTDKMASVFYTMVIPMLNPL 264
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 1-119 3.36e-52

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 165.57  E-value: 3.36e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15408   154 RLSFCGSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYtyilaTILRMRSAEGRHKAFSTCASH 233

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15408   234 LTAVTLFYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 1-119 1.67e-51

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 164.07  E-value: 1.67e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15943   155 RLPFCGSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYvyilsAILRIHSSEGRRKAFSTCASH 234

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15943   235 LMAVTIFYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPL 278
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 1-119 2.79e-51

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 163.26  E-value: 2.79e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15411   141 RLSFCGSNVINHFFCDTPPLLKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYtyilsTILKIRSAEGRRKAFSTCASH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15411   221 LTAVTIFYGTGIFTYLRPSSSYSLGQDKVASVFYTVVIPMLNPL 264
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 2-119 6.06e-50

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 159.49  E-value: 6.06e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15412   142 LSFCGSNVINHFYCADPPLIKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYlfiliAILRIRSAEGRCKAFSTCGSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15412   222 TAVTIFYGTLFCMYLRPPSEESVEQSKIVAVFYTFVSPMLNPL 264
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 1-119 1.38e-49

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 158.77  E-value: 1.38e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15225   141 SLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASVLVILVPFLLILVSYifiisTILKIPSAEGRRKAFSTCSSH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15225   221 LIVVTLFYGCASFTYLRPKSSYSPETDKLLSLFYTVVTPMLNPI 264
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 1-118 1.69e-47

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 153.57  E-value: 1.69e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15417   141 QLSFCGPNVIDHFFCDIPPLLSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYgyiisTILKIRSAKGRSKAFNTCASH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15417   221 LTAVTLFYGTGLFVYLRPSSSHSQDQDKVASVFYTVVIPMLNP 263
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 2-118 8.72e-47

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 151.10  E-value: 8.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15912   142 LPFCGPNVINHFFCDSGPLLKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYiyiisTILRIPSASGRQKAFSTCASHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15912   222 TVVSIFYGSCIFMYVRPSQSSSLDLNKVVALLNTVVTPLLNP 263
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 1-119 5.97e-46

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 149.89  E-value: 5.97e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15945   154 RLSFCGSNTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYcyiiiTVLKIRSAEGRFKAFSTCASH 233

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15945   234 LTAVGLFYGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPL 277
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 2-118 2.11e-45

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 148.28  E-value: 2.11e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYA-----ILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15406   151 LSFCGDNVINHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAfilssILRIRSAEGRSKAFSTCSSHL 230

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15406   231 AAVGVFYGSIIFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNP 272
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 1-119 3.49e-45

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 147.55  E-value: 3.49e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15409   141 RLSFCGSNEINHFFCDIPPLLKISCTDPSINELVLFIFSGSIQVFTILTVLISYsyilfTILKMKSAEGRRKAFSTCGSH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15409   221 LLSVSLFYGSLFFMYVRPSSLYALDQDMMDSLFYTIVIPLLNPF 264
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 1-119 6.72e-45

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 146.74  E-value: 6.72e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15416   141 SLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKILPSISSGIIILVTVLTIIISYlyiliAILRIRSTEGRHKAFSTCASH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15416   221 LTAVTLFYGTITFIYVMPNSSYSMDQNKVVSVFYMVVIPMLNPL 264
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 1-119 7.39e-45

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 146.68  E-value: 7.39e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYA-----ILRIHSAEGRQKAFSTCASH 75
Cdd:cd15419   141 SLSFCGSNEIDHFFCDVPPLLKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAyilstILRIPSAEGRKKAFSTCASH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15419   221 LTAVSLFYGTVFFMYAQPGAVSSPEQSKVVSVFYTLVIPMLNPL 264
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 2-119 1.00e-44

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 146.09  E-value: 1.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15911   142 LTFCGPNEIDHFFCDFAPLLKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYiciisTILRIPSTTGRQKAFSTCSSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15911   222 IVVTIFYGTLIIVYVVPSTNTSRDLNKVFSLFYTVLTPLVNPL 264
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 1-119 3.57e-44

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 145.31  E-value: 3.57e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15944   154 SLSFCGSNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYlfilvAILRMRSAEGRRKAFSTCASH 233

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15944   234 FTGVTLFYGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 1-119 1.44e-43

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 143.38  E-value: 1.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15418   142 RLHFCGDNIIDHFFCDLPPLVKLACDDTRVYELILYFILGFNVIAPTALILASYtfilaAILRIHSASGRHKAFSTCSAH 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15418   222 LTSVTLYYGSILFIYSRPSSSHTPDRDKVVALFYTVVNPLLNPL 265
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 2-119 1.51e-42

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 141.02  E-value: 1.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15414   142 LPFCGPNVINHFFCDIPPLLSLSCADTQINKWVLFIMAGALGVLSGLIILVSYiyiliAILRIRSAEGRRKAFSTCSSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15414   222 TAVSILYGTLFFIYVRPSSSSSLDLDKVVSVFYTAVIPMLNPL 264
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 2-118 1.95e-42

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 140.05  E-value: 1.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15431   141 LHFCGPNVINHFFCEVQALLKLACSDTSLNEILMFATSIFTLLLPFSFILVSYirigvAVLRIRSAEGRRKAFSTCGSHL 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15431   221 TVVTIFYGTAIFMYLRPQSKSSSDQDKIISVFYGVVTPMLNP 262
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 2-119 1.13e-41

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 138.32  E-value: 1.13e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15415   142 LSFCGPNVINHYFCDIPPLLKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYifilfAILRIRSAEGRRKAFSTCASHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15415   222 TAVTLFYGSVSFSYIQPSSQYSLEQEKVSAVFYTLVIPMLNPL 264
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 2-119 1.33e-39

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 133.16  E-value: 1.33e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15231   142 LSFCGSNQISHFFCDIPPLLKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYvyiisTILKIRSAEGRRKAFSTCASHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15231   222 TVVTLFYGTAIFNYNRPSSGYSLDKDTLISVLYSIVTPMLNPI 264
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 2-118 1.43e-39

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 132.74  E-value: 1.43e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15918   142 LSFCASNEIPHFFCDLNPLLKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYvrivsAVLRIPSAGGKWKAFSTCGSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15918   222 SVVSLFYGTVIGVYLSPPSSHSASKDSVAAVMYTVVTPMLNP 263
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 1-119 2.41e-39

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 132.35  E-value: 2.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15235   142 RLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYarilaAVLKVPSAAGRRKAFSTCGSH 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15235   222 LTVVALFYGTIIGVYFQPSSSYSADKDRVATVMYTVVTPMLNPF 265
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 1-119 3.94e-39

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 131.63  E-value: 3.94e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15237   141 RLPFCGPNHINHFFCEAPAVLKLACADTSLNEAVIFVTSVLVLLIPFSLILASYirilaTILRIQSAEGRKKAFSTCASH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15237   221 LTVVTLFYGTAIFMYMRPHSTHSPDQDKMISVFYTIVTPMLNPL 264
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 2-118 2.00e-37

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 127.35  E-value: 2.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15947   142 LPLCGHHTLDHFFCEVPALIKLACVDTTFNELELFVASVFFLLVPLSLILVSYgfiarAVLRIKSAEGRRKAFGTCSSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15947   222 LVVSLFYGTAIYMYLQPPSSYSQDQGKFISLFYTVVTPTLNP 263
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 2-119 2.23e-37

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 127.01  E-value: 2.23e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15224   142 LSFCGPNVINHFFCDISPLLNLSCTDMSLAELVDFILALIILLVPLLVTVASYiciisTVLRIPSATGRQKAFSTCASHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15224   222 TVVIIFYSATLFMYARPKAISSFDSNKLVSVLYTVVTPLLNPI 264
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 2-119 1.24e-36

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 125.18  E-value: 1.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15430   142 LPFCGNNVINHFTCEILAVLKLACVDISLNEIIMLVGNIIFLVIPLLLICISYifilsTILRINSAEGRKKAFSTCSAHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15430   222 TVVIIFYGTILFMYMKPKSKNAQISDKLITLFYGVVTPMLNPI 264
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 1-119 1.40e-36

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 124.87  E-value: 1.40e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15227   141 SLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYvhifsTVLRIPSAQGRSKAFSTCLPH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15227   221 LIVVSLFLSTGSFAYLKPPSDSPSLLDLLLSVFYSVVPPTLNPI 264
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 2-119 5.03e-36

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 123.52  E-value: 5.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15232   142 LSFCGPNIINHFFCEIPPLLLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYgfiirSILRIRSTEGKKKAFSTCSSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15232   222 IVVSLYYSTVIYTYIRPSSSYSPEKDKVVAVLYSVVTPTLNPL 264
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 1-119 2.33e-35

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 121.93  E-value: 2.33e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15229   141 NLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYihiisTILRIRSAEGRSKAFSTCSSH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15229   221 LTVVGLFYGTGFFRYLRPNSASSSVLDRVFSIQYSILTPMLNPI 264
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 2-119 2.43e-35

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 122.14  E-value: 2.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYA-----ILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15405   142 LTFCDSNIINHYMCDILPLLQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYAlilsnILHISSTEGRSKAFSTCSSHI 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15405   222 IAVSLFFGSGAFMYLKPSSVGSVNQGKVSSVFYTNVVPMLNPL 264
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 2-119 7.64e-35

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 120.90  E-value: 7.64e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15420   142 LPFCGPNEVNHFFCEILAVLKLACADTWINEILIFAGCVFILLGPFSLILISYlhilaAILKIQSAEGRRKAFSTCSSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15420   222 CVVGLFYGTAMFMYMVPGSSNSAEQEKILSLFYSLFNPMLNPL 264
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 5-119 2.32e-34

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 119.58  E-value: 2.32e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   5 CDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHLTSI 79
Cdd:cd15421   145 CGSREIHHFFCEVPALLKLSCADTSAYETVVYVSGVLFLLIPFSLILASYalillTVLRMRSAEGRKKALATCSSHLTVV 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1187837493  80 TIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15421   225 SLYYGPAIFTYMRPGSYHSPEQDKVVSVFYTILTPMLNPL 264
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 1-118 1.67e-33

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 117.48  E-value: 1.67e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15434   141 SLPRCGHHRVDHFFCEMPALIKLACVDTTAYEATIFALGVFILLFPLSLILVSYgyiarAVLKIKSAAGRKKAFGTCGSH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15434   221 LTVVSLFYGTIIYMYLQPKNSVSQDQGKFLTLFYTIVTPSLNP 263
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 2-119 5.31e-33

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 116.05  E-value: 5.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15233   142 LKFCGPNVINHFFCDLPPLFQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYahvvaAVLRIRSAEGRRKAFSTCGSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15233   222 TVVCIFYGTGVFSYMRLGSVYSSDKDKVIGILNTVLSPMLNPL 264
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 2-119 7.76e-33

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 115.58  E-value: 7.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15429   142 LPFCGHNTINHFSCELLAVVRLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYihiisAILRIRSSEGRHKAFSTCASHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15429   222 TVVSLCYGTAIFTYMRPRSGSSALQEKMISLFYAVVTPMLNPL 264
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 2-119 3.33e-32

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 113.85  E-value: 3.33e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYAI----LRIHSAEGRQKAFSTCASHLT 77
Cdd:cd15939   142 LPFCGPNVIDHFFCDLFPLLKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVilysLRTHSSEGRRKALSTCGSHIT 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  78 SITIFYGTIIFMYLLPKSSHSLntDKFASVFYVVAIPMLNPV 119
Cdd:cd15939   222 VVVLFFVPCIFIYMRPVTTFPI--DKVVAVFYTIITPMLNPL 261
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 2-119 3.71e-32

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 113.55  E-value: 3.71e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYA------ILRIHSAEGRQKAFSTCASH 75
Cdd:cd15915   142 LPFCGPNKINHFFCDIKPLLKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIyiisflLLKVRSKEGRHKAFSTCASH 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15915   222 LTVVLLLYGPALFTYIRPSSGDSLEQDRIVALLYTVVTPVLNPL 265
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 1-119 5.21e-31

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 110.92  E-value: 5.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15914   141 TLPFCGPNQIQHIFCDFPPLLSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYvkiisVVLKIPSAEGRQKAFSTCAAH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15914   221 LTVVLLFFGSVSFMYLRLSKSYSLDYDRAIAVVYAVLTPFFNPI 264
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 2-118 6.78e-31

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 110.63  E-value: 6.78e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15236   142 LSFCADNVIPHFFCDLVALLKLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYiriaaTILKVPSTKGICKAFSTCGSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15236   222 SVVFLYYGTIIGVYFFPSSNNSSDKDIVASVMYTVVTPMLNP 263
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 1-119 4.14e-30

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 108.44  E-value: 4.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYAI----LRIHSAEGRQKAFSTCASHL 76
Cdd:cd15226   141 NLPFCGPNVVDSFFCDLPLVIKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVilvtVRKHSSGGSSKALSTCSAHI 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSlnTDKFASVFYVVAIPMLNPV 119
Cdd:cd15226   221 TVVVLFFGPCIFIYVWPFSTFP--VDKFLAVFYTVITPLLNPI 261
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 5-119 2.24e-28

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 104.05  E-value: 2.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   5 CDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYA-----ILRIHSAEGRQKAFSTCASHLTSI 79
Cdd:cd15424   145 CGPNHINHFFCELPVVLKLACADTHITEAIVFGAGVLILLVPLSVILTSYGlilasVLQMQSAAGRHKAFSTCASHLAVV 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1187837493  80 TIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15424   225 TLFYGTVISMYMRPRSGSTPDRDKQIAVFYIVITPLLNPI 264
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 2-119 4.27e-28

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 103.29  E-value: 4.27e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYAI----LRIHSAEGRQKAFSTCASHLT 77
Cdd:cd15940   142 LPYCGPNEIDSFFCDVPPVIKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVilvsLRKRSTEGRRKALSTCASHLT 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  78 SITIFYGTIIFMYLLPKSSHSLntDKFASVFYVVAIPMLNPV 119
Cdd:cd15940   222 VVTLFFGPCIFIYTRPSTSFSE--DKVVSVFYTVVTPLLNPI 261
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 1-119 6.98e-28

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 102.56  E-value: 6.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15946   141 RLPYCGPNEINHYFCEVPAVLKLACADTSLNEMVDFVLGVIVLVVPLSLILASYvnifkAILKIRSTQGRCKAFSTCASH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15946   221 ITVVTMFYGPAMFMYMRPGSNYSPERDKKISLFYNVFTALLNPV 264
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 2-119 1.05e-27

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 102.01  E-value: 1.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15913   142 LPFCGPNIIDHFLCDPGPLLALSCVPAPGTELICYTLSSLIIFGTFLFILGSYtlvlrAVLRVPSAAGRHKAFSTCGSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15913   222 AVVSLFYGSVMVMYVSPGSGNSTGMQKIVTLFYSVVTPLLNPL 264
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 2-119 1.32e-27

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 102.14  E-value: 1.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15916   143 LPFCGPNRIDYFFCDIPPLLKLACADTTINELVIFASIGVVALGCFILILLSYgnivrAILRIRTAEGRRRAFSTCASHL 222

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLntDKFASVFYVVAIPMLNPV 119
Cdd:cd15916   223 IVVLCFYVPCVFIYLRPGSKEAL--DGVIAVFYTVVTPLLNPL 263
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 2-118 7.08e-27

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 100.20  E-value: 7.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15228   142 LPYCGSNVVDYFFCDIFPVLKLACADTSIAETVSFTNVGLVPLTCFLLILASYvriviSILKMRSAEGRRKAFSTCSSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTdkFASVFYVVAIPMLNP 118
Cdd:cd15228   222 TVVTLFFGPCALIYTQPTPSPVLVT--PVQIFNNVVTPMLNP 261
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 4-119 3.11e-26

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 98.32  E-value: 3.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   4 LCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHLTS 78
Cdd:cd15432   144 RCGRRRVDHFFCEVPALLKLSCVDTTANEAELFVISVLLLLIPLGLILISYifivrAVLRIRSAEGRRKAFNTCGSHLLV 223

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1187837493  79 ITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15432   224 VSLFYGTAISMYLQPPSNSSHDRGKMVALFYGIITPMLNPL 264
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 2-119 6.44e-26

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 97.55  E-value: 6.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYA-----ILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15428   142 LSFGGHNKINHFLCEMPALLKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTriiytVFGMQSLTGRLKAFSTCSSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15428   222 MVVSLFYGSVLSTYMRPKSSTSKEYDKMISVFYIIVTPMLNPL 264
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 2-118 8.85e-26

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 97.23  E-value: 8.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15941   144 LPYCGPCQIAYFFCDIPPVLKLACADTTINELVILANIGIVAAGCFLLIVISYiyivaAVLRIRTAEGRQRAFSTCSAHL 223

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSlnTDKFASVFYVVAIPMLNP 118
Cdd:cd15941   224 TGVLLYYVPSVFIYLQPSSSQA--GAGAPAVFYTIVTPMLNP 263
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 2-119 3.86e-25

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 95.32  E-value: 3.86e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYA--ILRIHSAEGRQKAFSTCASHLTSI 79
Cdd:cd15938   142 LPFCGPNQVNNFFCDVPPVIKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTtiLVTIRSTEGRRKALSTCASHLMVV 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1187837493  80 TIFYGTIIFMYLLPKSSHSlnTDKFASVFYVVAIPMLNPV 119
Cdd:cd15938   222 TLFFGPCIFIYARPFSTFP--VDKHVSVLYNVITPMLNPL 259
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 12-118 1.60e-24

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 93.80  E-value: 1.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493  12 HFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHLTSITIFYGTI 86
Cdd:cd15234   152 HFFCELAQVLKLACSDTLINNILIYLATVIFGGIPLSGIIFSYykivsSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTG 231

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1187837493  87 IFMYLLPKSSHSLNTDKFASVFYVVAIPMLNP 118
Cdd:cd15234   232 LGVYISSAVTHSSRKTAVASVMYTVVTPMLNP 263
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 2-119 1.67e-24

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 93.55  E-value: 1.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYAI----LRIHSAEGRQKAFSTCASHLT 77
Cdd:cd15936   142 LPFCGPNVLDNFYCDVPQVIKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVilvkIRTHVTEGKRKALSTCASQIT 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  78 SITIFYGTIIFMYLLPksSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15936   222 VVTLIFVPCIYIYARP--FQTFPMDKAVSVLYTVITPMLNPM 261
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 2-119 2.27e-24

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 93.29  E-value: 2.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYAI----LRIHSAEGRQKAFSTCASHLT 77
Cdd:cd15935   143 LPFCGPNELDNFYCDVPQVIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIilttLRGRFREGGGKALSTCSSHLT 222

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  78 SITIFYGTIIFMYLLPKSSHSLntDKFASVFYVVAIPMLNPV 119
Cdd:cd15935   223 VVSLIFVPCIFVYLRPFSSSSV--DKVASVFYTLITPALNPL 262
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 2-119 3.55e-23

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 90.57  E-value: 3.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15942   142 LPYGQKNEVDYIFCDIPAMLKLACADTAFNELVTFIDIGLVAMTCFLLILMSYvyivsAILKIPSAEGQRRAFSTCTAHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLntDKFASVFYVVAIPMLNPV 119
Cdd:cd15942   222 TVVVIYYVPLTFIYLRPGSQDPL--DGVVAVFYTTVTPLLNPV 262
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 2-119 2.72e-20

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 82.92  E-value: 2.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15433   142 RPLCGHRLLDHFFCEMPVFLKLACGDDETTEVQMFVARVVILLLPAALILGSYghvahAVLRIKSSAGRRRAFGTCGSHL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15433   222 MVVFLFYGSAIYTYLQPIHRYSQAHGKFVSLFYTVMTPALNPL 264
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 1-119 8.79e-20

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 81.57  E-value: 8.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15223   141 QLSYCSSNVIEHCYCDHMALVSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYalilrAVLRLASGEARSKALNTCGSH 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1187837493  76 LTSITIFYGTIIFMYLLPKSSHSLNTD--KFASVFYVVAIPMLNPV 119
Cdd:cd15223   221 LIVILFFYTAVLVSSLTYRFGKTIPPDvhVLLSVLYILIPPALNPI 266
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 2-119 2.90e-18

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 77.33  E-value: 2.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15917   142 LPYCGSNVISHSYCEHMAVVKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYvlilrAVLQLPSKEARLKALSTCGSHI 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSL--NTDKFASVFYVVAIPMLNPV 119
Cdd:cd15917   222 CVILIFYTPALFSFLTHRFGHHVppHVHILLANLYLLLPPMLNPI 266
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 2-119 6.11e-18

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 76.31  E-value: 6.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISYAIL----RIHSAEGRQKAFSTCASHLT 77
Cdd:cd15937   142 LPFCGPNVLDNFFCDITQVIKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLlaklRTHSSKGKSKAASTCITHII 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  78 SITIFYGTIIFMYLLPKSSHSLntDKFASVFYVVAIPMLNPV 119
Cdd:cd15937   222 IVFVMFGPAIYIYARPFRSFPM--DKVVAVFHTVIFPLLNPM 261
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 5-119 7.34e-16

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 70.84  E-value: 7.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   5 CDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHLTSI 79
Cdd:cd15951   145 CRTNIIPHTYCEHMAVVKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYiqilrAVFKLPSKEARLKTFGTCGSHICVI 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  80 TIFYGTIIFMYLLPKSSHS--LNTDKFASVFYVVAIPMLNPV 119
Cdd:cd15951   225 LVFYIPALFSFLTHRFGHNvpPHVHILIANVYLLVPPMLNPI 266
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 2-119 2.38e-15

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 69.60  E-value: 2.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15953   142 LPFCANRIIPHTYCEHMAVVKLACGDTTINRIYGLVVALLVVGLDLLLIALSYaliirAVLRLSSKKARQKALNTCTAHI 221

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1187837493  77 TSITIFYGTIIFMYL-------LPKSSHSLntdkFASVFYVVAiPMLNPV 119
Cdd:cd15953   222 CVILMSYTPALFSFLthrfgqgIAPHIHII----LANLYLLVP-PMLNPI 266
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 1-119 3.80e-15

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 68.98  E-value: 3.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   1 SLVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASH 75
Cdd:cd15950   141 SLPYCGSRVVPHSYCEHMAVVKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYglilrAVLGLSSKEARLKAFSTCGSH 220

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1187837493  76 LTSITIFY-GTIIFMYL------LPKSSHSLNTDkfasvFYVVAIPMLNPV 119
Cdd:cd15950   221 VCVILLFYiPGLLSIYTqrfgqgVPPHTQVLLAD-----LYLLVPPMLNPI 266
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 2-119 6.11e-15

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 68.56  E-value: 6.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVI----ISYAILRIHSAEGRQKAFSTCASHLT 77
Cdd:cd15952   142 LPFCGHNIIPHTYCEHMGIAKLACASIRINIIYGLFAISVLVLDVILIALsyvlILRAVFRLPSHDARLKALSTCGSHVC 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1187837493  78 SITIFYGTIIFMYL-------LPKSSHSLntdkfASVFYVVAIPMLNPV 119
Cdd:cd15952   222 VILAFYTPALFSFLthrfghnIPRYIHIL-----LANLYVVLPPMLNPV 265
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 2-119 2.33e-14

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 66.93  E-value: 2.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15221   142 LPYCGHNVIPHTYCEHMGIARLACADITVNIWYGLTVALLTVGLDVVLIAVSYalilrAVFRLPSKDARLKALSTCGSHV 221

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1187837493  77 TSITIFYGTIIFMYL-------LPKSSHSLntdkFASVfYVVAIPMLNPV 119
Cdd:cd15221   222 CVILMFYTPAFFSFLthrfgrhIPRHVHIL----LANL-YVLVPPMLNPI 266
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 5-119 2.40e-14

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 66.85  E-value: 2.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   5 CDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHLTSI 79
Cdd:cd15948   146 CRSHVIAHCYCEHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYvfilrAVLSLASKEEQLKAFGTCGSHICAI 225

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  80 TIFYGTIIFMYLLPKSSHSL--NTDKFASVFYVVAIPMLNPV 119
Cdd:cd15948   226 LVFYTPVVLSSTMHRFARHVapHVHILLANFYLLFPPMMNPI 267
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 2-119 5.17e-13

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 63.26  E-value: 5.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15949   158 LPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYimilrVVQRLATSEARLKTFGTCVSHV 237

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLN--TDKFASVFYVVAIPMLNPV 119
Cdd:cd15949   238 CAILAFYVPIAVSSLIHRFGQNVPppTHILLANFYLLIPPMLNPI 282
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 2-119 2.93e-12

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 61.03  E-value: 2.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   2 LVLCDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHL 76
Cdd:cd15956   142 LSFCASHTIAHTYCEHMAVVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYglivkTVLRLPSPEARGKAFSTCSAHI 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1187837493  77 TSITIFYGTIIFMYLLPKSSHSLNTDK--FASVFYVVAIPMLNPV 119
Cdd:cd15956   222 CVILFFYIPGLLSVLMHRFGHSVPSAAhvLLSNLYLLLPPALNPI 266
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 5-119 8.55e-12

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 59.82  E-value: 8.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   5 CDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHLTSI 79
Cdd:cd15222   145 CHSNVLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYvlilkTVLGIASREERLKALNTCVSHICAV 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  80 TIFYGTII---FMYLLPKSSHSLNTDKFASVfYVVAIPMLNPV 119
Cdd:cd15222   225 LIFYVPMIglsMVHRFGKHASPLVHVLMANV-YLLVPPVLNPI 266
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 5-119 1.08e-11

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 59.45  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   5 CDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVA----GFNTLC-SLLIVIISYAILRIHSAEGRQKAFSTCASHLTSI 79
Cdd:cd15954   145 CRGNFIPHTYCDHMSVVKLACANIRVDAIYGLMVAlligGFDILCiSVSYAMILRAVVSLSSKEARSKAFSTCTAHICAI 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1187837493  80 TIFYGTIIFMYLLPK-SSHSL--NTDKFASVFYVVAIPMLNPV 119
Cdd:cd15954   225 VITYTPAFFTFFAHRfGGHHItpHIHIIMANLYLLLPPMMNPI 267
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 5-119 5.25e-11

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 57.51  E-value: 5.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   5 CDSNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHLTSI 79
Cdd:pfam13853 139 CGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLIVLSYglilrTVLGIASREGRLKALNTCGSHVCAV 218

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837493  80 TIFYGTIIFMYLLPKSSHSLN--TDKFASVFYVVAIPMLNPV 119
Cdd:pfam13853 219 LAFYTPMIGLSMVHRFGHNVPplLQIMMANAYLFFPPVLNPI 260
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 7-119 1.41e-07

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 48.23  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837493   7 SNVVNHFYCDGVPLVALACSDTQVKELLLLIVAGFNTLCSLLIVIISY-----AILRIHSAEGRQKAFSTCASHLTSITI 81
Cdd:cd15955   148 STVISHSYCEHMAVVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYalifrAVFRLPQKEARLKAFNTCTAHIFVFLL 227

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1187837493  82 FYGTIIFMYLLPKSSHSL--NTDKFASVFYVVAIPMLNPV 119
Cdd:cd15955   228 FYTLAFFSFFAHRFGHHVapYVHILLSNLYLLVPPVLNPI 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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