seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257   7 PQDVNELLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLL 86
Cdd:cd15235    56 PKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  87 HVLLVNQLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAF 166
Cdd:cd15235   136 HTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAF 215

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1187837257 167 STCSSHLTVVTLFYGSIGFVYFQPLSSYTA-KDRIATIIYTVLTPM 211
Cdd:cd15235   216 STCGSHLTVVALFYGTIIGVYFQPSSSYSAdKDRVATVMYTVVTPM 261

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257   7 PQDVNELLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLL 86
Cdd:cd15235    56 PKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  87 HVLLVNQLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAF 166
Cdd:cd15235   136 HTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAF 215

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1187837257 167 STCSSHLTVVTLFYGSIGFVYFQPLSSYTA-KDRIATIIYTVLTPM 211
Cdd:cd15235   216 STCGSHLTVVALFYGTIIGVYFQPSSSYSAdKDRVATVMYTVVTPM 261

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257   7 PQDVNELLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLL 86
Cdd:cd15235    56 PKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  87 HVLLVNQLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAF 166
Cdd:cd15235   136 HTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAF 215

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1187837257 167 STCSSHLTVVTLFYGSIGFVYFQPLSSYTA-KDRIATIIYTVLTPM 211
Cdd:cd15235   216 STCGSHLTVVALFYGTIIGVYFQPSSSYSAdKDRVATVMYTVVTPM 261

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  13 LLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLLHVLLVN 92
Cdd:cd15225    61 LLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  93 QLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSSH 172
Cdd:cd15225   141 SLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSH 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1187837257 173 LTVVTLFYGSIGFVYFQPLSSYTA-KDRIATIIYTVLTPM 211
Cdd:cd15225   221 LIVVTLFYGCASFTYLRPKSSYSPeTDKLLSLFYTVVTPM 260

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  13 LLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLLHVLLVN 92
Cdd:cd15230    61 FLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  93 QLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSSH 172
Cdd:cd15230   141 SLSFCGSNVINHFFCDIPPLLKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASH 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1187837257 173 LTVVTLFYGSIGFVYFQPLSSY-TAKDRIATIIYTVLTPM 211
Cdd:cd15230   221 LTAVSLFYGTLIFMYLRPSSSYsLDQDKVVSVFYTVVIPM 260

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257   7 PQDVNELLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLL 86
Cdd:cd15408    68 PKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTV 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  87 HVLLVNQLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAF 166
Cdd:cd15408   148 HTGFILRLSFCGSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAF 227

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1187837257 167 STCSSHLTVVTLFYGSIGFVYFQPLSSYTAK-DRIATIIYTVLTPM 211
Cdd:cd15408   228 STCASHLTAVTLFYGSLAFMYLRPSSRYSLDlDKVASVFYTVVIPM 273

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  13 LLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLLHVLLVN 92
Cdd:cd15911    61 LLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMS 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  93 QLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSSH 172
Cdd:cd15911   141 QLTFCGPNEIDHFFCDFAPLLKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSH 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1187837257 173 LTVVTLFYGSIGFVYFQPlSSYTAKD--RIATIIYTVLTPM 211
Cdd:cd15911   221 LIVVTIFYGTLIIVYVVP-STNTSRDlnKVFSLFYTVLTPL 260

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257   7 PQDVNELLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLL 86
Cdd:cd15237    55 PQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  87 HVLLVNQLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAF 166
Cdd:cd15237   135 LTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAF 214

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1187837257 167 STCSSHLTVVTLFYGSIGFVYFQPLSSYTA-KDRIATIIYTVLTPM 211
Cdd:cd15237   215 STCASHLTVVTLFYGTAIFMYMRPHSTHSPdQDKMISVFYTIVTPM 260

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  14 LSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLLHVLLVNQ 93
Cdd:cd15227    62 LTNTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFS 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  94 LTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSSHL 173
Cdd:cd15227   142 LPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHL 221

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1187837257 174 TVVTLFYGSIGFVYFQPLSSY-TAKDRIATIIYTVLTPM 211
Cdd:cd15227   222 IVVSLFLSTGSFAYLKPPSDSpSLLDLLLSVFYSVVPPT 260

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  13 LLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLLHVLLVN 92
Cdd:cd15419    61 FLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  93 QLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSSH 172
Cdd:cd15419   141 SLSFCGSNEIDHFFCDVPPLLKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASH 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1187837257 173 LTVVTLFYGSIGFVYFQPLS-SYTAKDRIATIIYTVLTPM 211
Cdd:cd15419   221 LTAVSLFYGTVFFMYAQPGAvSSPEQSKVVSVFYTLVIPM 260

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257   7 PQDVNELLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLL 86
Cdd:cd15411    55 PKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLI 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  87 HVLLVNQLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAF 166
Cdd:cd15411   135 HTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAF 214

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1187837257 167 STCSSHLTVVTLFYGSIGFVYFQPLSSYT-AKDRIATIIYTVLTPM 211
Cdd:cd15411   215 STCASHLTAVTIFYGTGIFTYLRPSSSYSlGQDKVASVFYTVVIPM 260

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  14 LSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLL--VFSIAFSCLHSLLHVLLv 91
Cdd:cd15406    71 VSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVagVYIMGLIGATVHTSCML- 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  92 nQLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSS 171
Cdd:cd15406   150 -RLSFCGDNVINHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSS 228

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1187837257 172 HLTVVTLFYGSIGFVYFQPLSSY-TAKDRIATIIYTVLTPM 211
Cdd:cd15406   229 HLAAVGVFYGSIIFMYLKPSSSSsMTQEKVSSVFYTTVIPM 269

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  18 KTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLLHVLLVNQLTFC 97
Cdd:cd15234    66 KSISYTGCLTQMCFFLLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFC 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  98 ASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSSHLTVVT 177
Cdd:cd15234   146 TDVEIPHFFCELAQVLKLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVS 225

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1187837257 178 LFYGSIGFVYFQP-LSSYTAKDRIATIIYTVLTPM 211
Cdd:cd15234   226 LFYGTGLGVYISSaVTHSSRKTAVASVMYTVVTPM 260

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  13 LLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLLHVLLVN 92
Cdd:cd15229    61 LLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  93 QLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSSH 172
Cdd:cd15229   141 NLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSH 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1187837257 173 LTVVTLFYGSIGFVYFQPLS-SYTAKDRIATIIYTVLTPM 211
Cdd:cd15229   221 LTVVGLFYGTGFFRYLRPNSaSSSVLDRVFSIQYSILTPM 260

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257   7 PQDVNELLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLL 86
Cdd:cd15420    55 PHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  87 HVLLVNQLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAF 166
Cdd:cd15420   135 HVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAF 214

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1187837257 167 STCSSHLTVVTLFYGSIGFVYFQPLSSYTA-KDRIATIIYTVLTPM 211
Cdd:cd15420   215 STCSSHLCVVGLFYGTAMFMYMVPGSSNSAeQEKILSLFYSLFNPM 260

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  13 LLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLLHVLLVN 92
Cdd:cd15430    61 FLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAM 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  93 QLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSSH 172
Cdd:cd15430   141 QLPFCGNNVINHFTCEILAVLKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAH 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1187837257 173 LTVVTLFYGSIGFVYFQPLSSYT-AKDRIATIIYTVLTPM 211
Cdd:cd15430   221 LTVVIIFYGTILFMYMKPKSKNAqISDKLITLFYGVVTPM 260

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  13 LLSDAKTISYAECLAQMYFFLLFGNMDSYLLAAMAIDRYVAICNPFYYVTVMNHRCCMSLLVFSIAFSCLHSLLHVLLVN 92
Cdd:cd15416    61 FLVEKTTISYPGCAAQLCSAATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837257  93 QLTFCASNVILPLFCDVNPVLKLACSSTSVNEVVAKTEGIVSVMAPFACIIISYLRILIAVFNIPSVAGKCKAFSTCSSH 172
Cdd:cd15416   141 SLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASH 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1187837257 173 LTVVTLFYGSIGFVYFQPLSSYTA-KDRIATIIYTVLTPM 211
Cdd:cd15416   221 LTAVTLFYGTITFIYVMPNSSYSMdQNKVVSVFYMVVIPM 260