NCBI Conserved Domain Search

Conserved domains on [gi|1187837223|gb|ARM55243|]

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olfactory receptor family 4, partial [Vampyrum spectrum]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

1-222

1.67e-142

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 398.51 E-value: 1.67e-142

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15939    39 LSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15939   119 LLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 LHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15939   199 YSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPIDKVVAVFYTIITPMLNP 260

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

1-222

1.67e-142

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 398.51 E-value: 1.67e-142

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15939    39 LSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15939   119 LLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 LHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15939   199 YSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPIDKVVAVFYTIITPMLNP 260

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

1-222

5.62e-29

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 109.51 E-value: 5.62e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:pfam13853  33 LAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTILTNPVIS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSD---TFLIGLLIVAnggTLSVFCFVILLTSYV 157
Cdd:pfam13853 113 RIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADikvNNIYGLFVVT---STFGIDSLLIVLSYG 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223 158 VILLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYL--RPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:pfam13853 190 LILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPplLQIMMANAYLFFPPVLNP 259

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

1-222

1.67e-142

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 398.51 E-value: 1.67e-142

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15939    39 LSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15939   119 LLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 LHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15939   199 YSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPIDKVVAVFYTIITPMLNP 260

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

1-222

9.98e-118

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 335.71 E-value: 9.98e-118

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15226    39 LANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15226   119 LLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 LHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15226   199 VTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPVDKFLAVFYTVITPLLNP 260

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

1-222

6.51e-110

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 315.96 E-value: 6.51e-110

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd13954    39 LSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd13954   119 LLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd13954   199 STiLKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSsySSDLDKVVSVFYTVVTPMLNP 263

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

1-222

5.31e-109

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 313.99 E-value: 5.31e-109

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15940    39 LSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15940   119 WLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 LHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15940   199 VSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSEDKVVSVFYTVVTPLLNP 260

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

1-222

1.07e-105

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 305.41 E-value: 1.07e-105

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15936    39 LANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCT 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15936   119 GLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 LHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15936   199 VKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPMDKAVSVLYTVITPMLNP 260

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

1-222

1.41e-104

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 302.50 E-value: 1.41e-104

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15230    39 LSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15230   119 QLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPM--DKVVAVFYTVITPLLNP 222
Cdd:cd15230   199 ITiLRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNP 263

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

1-222

1.43e-101

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 295.13 E-value: 1.43e-101

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15225    39 LRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15225   119 QLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRP--SATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15225   199 STiLKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPksSYSPETDKLLSLFYTVVTPMLNP 263

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

1-222

2.80e-93

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 274.06 E-value: 2.80e-93

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15938    39 LGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCW 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15938   119 VLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 lhLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15938   199 --VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPVDKHVSVLYNVITPMLNP 258

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

1-222

1.61e-91

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 269.35 E-value: 1.61e-91

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15912    39 LRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15912   119 QLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSAT--LPMDKVVAVFYTVITPLLNP 222
Cdd:cd15912   199 STiLRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSssLDLNKVVALLNTVVTPLLNP 263

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

1-222

2.54e-90

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 266.77 E-value: 2.54e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15229    39 LSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15229   119 QLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSAT--LPMDKVVAVFYTVITPLLNP 222
Cdd:cd15229   199 STiLRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAssSVLDRVFSIQYSILTPMLNP 263

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

1-222

2.94e-90

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 266.22 E-value: 2.94e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15937    39 LANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCC 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15937   119 VLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 LHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15937   199 AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFPMDKVVAVFHTVIFPLLNP 260

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

1-222

3.42e-90

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 266.24 E-value: 3.42e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15227    39 LKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15227   119 QMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIF 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15227   199 STvLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPslLDLLLSVFYSVVPPTLNP 263

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

1-222

4.42e-89

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 263.16 E-value: 4.42e-89

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15935    40 LANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15935   120 KLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIIL 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 LHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15935   200 TTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSSVDKVASVFYTLITPALNP 261

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

1-222

1.21e-88

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 262.58 E-value: 1.21e-88

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15417    39 LSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15417   119 QLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15417   199 STiLKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSshSQDQDKVASVFYTVVIPMLNP 263

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

1-222

2.86e-88

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 262.30 E-value: 2.86e-88

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15943    53 LSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCI 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15943   133 QLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYIL 212

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15943   213 SAiLRIHSSEGRRKAFSTCASHLMAVTIFYGTTLFMYLRPSSsySLDQDKVVSVFYTVVIPMLNP 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

1-222

1.27e-87

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 259.72 E-value: 1.27e-87

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15911    39 LGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15911   119 QLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15911   199 STiLRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSrdLNKVFSLFYTVLTPLVNP 263

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

1-222

6.79e-87

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 257.86 E-value: 6.79e-87

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15421    39 LSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15421   119 LMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTSAYETVVYVSGVLFLLIPFSLILASYALIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15421   199 LTvLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSyhSPEQDKVVSVFYTILTPMLNP 263

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

1-222

2.89e-86

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 256.42 E-value: 2.89e-86

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15231    39 LSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15231   119 QLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSAT--LPMDKVVAVFYTVITPLLNP 222
Cdd:cd15231   199 STiLKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGysLDKDTLISVLYSIVTPMLNP 263

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

1-222

6.45e-86

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 255.23 E-value: 6.45e-86

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15918    39 LANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15918   119 LLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIV 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPM--DKVVAVFYTVITPLLNP 222
Cdd:cd15918   199 SAvLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSAskDSVAAVMYTVVTPMLNP 263

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

1-222

1.94e-85

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 254.45 E-value: 1.94e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15235    40 LSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15235   120 LLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARIL 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15235   200 AAvLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSsySADKDRVATVMYTVVTPMLNP 264

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

1-222

2.64e-85

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 253.77 E-value: 2.64e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15915    39 LGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15915   119 LLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1187837223 161 LHL--RTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15915   199 SFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSgdSLEQDRIVALLYTVVTPVLNP 264

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

1-222

9.26e-85

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 253.01 E-value: 9.26e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15408    52 LSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCV 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15408   132 SLVAGSYLAGFLNSTVHTGFILRLSFCGSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYIL 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15408   212 ATiLRMRSAEGRHKAFSTCASHLTAVTLFYGSLAFMYLRPSSrySLDLDKVASVFYTVVIPMLNP 276

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

1-222

3.35e-84

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 251.04 E-value: 3.35e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15237    39 LSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15237   119 RLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15237   199 ATiLRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSpdQDKMISVFYTIVTPMLNP 263

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

1-222

2.16e-83

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 249.29 E-value: 2.16e-83

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKR-KTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQAC 79
Cdd:cd15916    39 LGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLC 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  80 AVLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVI 159
Cdd:cd15916   119 TRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTTINELVIFASIGVVALGCFILILLSYGNI 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837223 160 LLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15916   199 VRAiLRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEALDGVIAVFYTVVTPLLNP 262

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

1-222

2.56e-83

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 249.50 E-value: 2.56e-83

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15410    52 LSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCV 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15410   132 LLVAGSYLWGIVCSLIHTCGLLRLSFCGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFII 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15410   212 VTiLRIRSAEGRQKAFSTCASHLTAITIFHGTILFMYCRPSSsySLDTDKVASVFYTVVIPMLNP 276

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

4-222

5.24e-82

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 245.25 E-value: 5.24e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   4 LSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLV 83
Cdd:cd15232    42 LSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  84 GIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVILLH- 162
Cdd:cd15232   122 TGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSi 201

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 163 LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15232   202 LRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSsySPEKDKVVAVLYSVVTPTLNP 263

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

1-222

6.20e-82

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 245.69 E-value: 6.20e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15411    39 LSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15411   119 KLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRP--SATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15411   199 STiLKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPssSYSLGQDKVASVFYTVVIPMLNP 263

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

1-222

6.00e-81

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 243.11 E-value: 6.00e-81

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15228    39 LCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15228   119 LLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIV 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15228   199 ISiLKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPVLVTPVQIFNNVVTPMLNP 261

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

1-222

7.69e-81

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 242.66 E-value: 7.69e-81

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15416    39 LSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15416   119 LLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMD--KVVAVFYTVITPLLNP 222
Cdd:cd15416   199 IAiLRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDqnKVVSVFYMVVIPMLNP 263

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

1-222

3.97e-80

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 240.69 E-value: 3.97e-80

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15420    39 LSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCT 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15420   119 TLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWINEILIFAGCVFILLGPFSLILISYLHIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15420   199 AAiLKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSaeQEKILSLFYSLFNPMLNP 263

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

1-222

4.74e-80

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 240.69 E-value: 4.74e-80

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15413    39 LRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15413   119 VLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSAT--LPMDKVVAVFYTVITPLLNP 222
Cdd:cd15413   199 SAiLRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSShsLDTDKMASVFYTLVIPMLNP 263

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

1-222

8.52e-80

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 240.29 E-value: 8.52e-80

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15419    39 LMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15419   119 QLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPM--DKVVAVFYTVITPLLNP 222
Cdd:cd15419   199 STiLRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPeqSKVVSVFYTLVIPMLNP 263

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

1-222

9.63e-80

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 239.43 E-value: 9.63e-80

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15431    39 LSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQIlLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15431   119 QLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALLKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIG 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15431   198 VAvLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSksSSDQDKIISVFYGVVTPMLNP 262

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

1-222

2.43e-78

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 236.03 E-value: 2.43e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15224    39 LSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15224   119 QLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSLAELVDFILALIILLVPLLVTVASYICII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMD--KVVAVFYTVITPLLNP 222
Cdd:cd15224   199 STvLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDsnKLVSVLYTVVTPLLNP 263

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

1-222

3.73e-78

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 235.76 E-value: 3.73e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15409    39 LGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15409   119 QLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15409   199 FTiLKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSlyALDQDMMDSLFYTIVIPLLNP 263

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

1-222

1.15e-77

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 234.60 E-value: 1.15e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15429    39 LSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15429   119 QLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15429   199 SAiLRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSalQEKMISLFYAVVTPMLNP 263

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

1-222

4.41e-77

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 232.90 E-value: 4.41e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15947    39 LSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTfliglliVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15947   119 QLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDT-------TFNELELFVASVFFLLVPLSLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 161 LH--------LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMD--KVVAVFYTVITPLLNP 222
Cdd:cd15947   192 VSygfiaravLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDqgKFISLFYTVVTPTLNP 263

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

1-222

1.44e-76

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 231.90 E-value: 1.44e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15412    39 LSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFL--IGLLIVAnGGTLSVFCFVILLtSYVV 158
Cdd:cd15412   119 SLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVkeTAMFIVA-GFNLSSSLLIILI-SYLF 196

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837223 159 ILLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15412   197 ILIAiLRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSeeSVEQSKIVAVFYTFVSPMLNP 263

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

1-222

3.45e-76

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 230.76 E-value: 3.45e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15415    39 LSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15415   119 QLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15415   199 FAiLRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSqySLEQEKVSAVFYTLVIPMLNP 263

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

1-222

1.95e-75

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 229.24 E-value: 1.95e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15414    39 LSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15414   119 QLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15414   199 IAiLRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSssSLDLDKVVSVFYTAVIPMLNP 263

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

1-222

2.34e-74

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 226.16 E-value: 2.34e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15942    39 LCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15942   119 CLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIV 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15942   199 SAiLKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPLDGVVAVFYTTVTPLLNP 261

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

1-222

1.53e-73

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 223.79 E-value: 1.53e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15914    39 ISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCT 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYV-VI 159
Cdd:cd15914   119 QLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVkII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 160 LLHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPM--DKVVAVFYTVITPLLNP 222
Cdd:cd15914   199 SVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLdyDRAIAVVYAVLTPFFNP 263

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

1-222

3.83e-73

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 223.47 E-value: 3.83e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15945    52 LSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCY 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15945   132 LLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYII 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15945   212 ITvLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYLRPSSsySLDTDKMTSVFYTLVIPMLNP 276

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

1-222

1.37e-71

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 219.33 E-value: 1.37e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKR-KTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQAC 79
Cdd:cd15941    40 LGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMC 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  80 AVLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVI 159
Cdd:cd15941   120 AGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTTINELVILANIGIVAAGCFLLIVISYIYI 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837223 160 LLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15941   200 VAAvLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQAGAGAPAVFYTIVTPMLNP 263

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

1-222

2.84e-71

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 218.78 E-value: 2.84e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15406    48 LSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCS 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15406   128 LLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFIL 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMD--KVVAVFYTVITPLLNP 222
Cdd:cd15406   208 SSiLRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNP 272

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

1-222

9.04e-71

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 216.85 E-value: 9.04e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15430    39 LGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15430   119 QMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15430   199 STiLRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSknAQISDKLITLFYGVVTPMLNP 263

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

1-222

1.23e-68

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 212.34 E-value: 1.23e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15944    52 LCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCL 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15944   132 QLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFIL 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15944   212 VAiLRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYLRPTSvySLDQDKWASVFYTVVIPMLNP 276

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

1-222

1.87e-67

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 208.59 E-value: 1.87e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15234    39 LSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15234   119 LLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIV 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSAT-LPMDKVVA-VFYTVITPLLNP 222
Cdd:cd15234   199 SSiLRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVThSSRKTAVAsVMYTVVTPMLNP 263

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

1-222

3.08e-67

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 208.05 E-value: 3.08e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15424    39 LSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15424   119 QLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRP-SATLP-MDKVVAVFYTVITPLLNP 222
Cdd:cd15424   199 ASvLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPrSGSTPdRDKQIAVFYIVITPLLNP 263

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

4-222

3.75e-67

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 208.10 E-value: 3.75e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   4 LSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLV 83
Cdd:cd15418    43 LSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  84 GIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVILLH- 162
Cdd:cd15418   123 AASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAi 202

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 163 LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSA--TLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15418   203 LRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSshTPDRDKVVALFYTVVNPLLNP 264

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

1-222

9.44e-67

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 206.89 E-value: 9.44e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15407    39 LSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15407   119 CLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIF 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPM--DKVVAVFYTVITPLLNP 222
Cdd:cd15407   199 ITiLRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMdtDKMASVFYTMVIPMLNP 263

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

1-222

1.17e-66

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 206.46 E-value: 1.17e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15434    39 LANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCW 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15434   119 KLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIA 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMD--KVVAVFYTVITPLLNP 222
Cdd:cd15434   199 RAvLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDqgKFLTLFYTIVTPSLNP 263

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

4-222

1.45e-65

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 203.80 E-value: 1.45e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   4 LSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLV 83
Cdd:cd15405    42 LSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLM 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  84 GIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVILLH- 162
Cdd:cd15405   122 LGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNi 201

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 163 LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMD--KVVAVFYTVITPLLNP 222
Cdd:cd15405   202 LHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNqgKVSSVFYTNVVPMLNP 263

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

1-222

1.60e-65

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 203.32 E-value: 1.60e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15913    39 LGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15913   119 KLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15913   199 RAvLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNStgMQKIVTLFYSVVTPLLNP 263

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

1-222

6.93e-64

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 199.24 E-value: 6.93e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15946    39 LSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15946   119 LMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIF 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15946   199 KAiLKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSpeRDKKISLFYNVFTALLNP 263

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

1-222

2.11e-63

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 198.45 E-value: 2.11e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15236    39 LSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15236   119 LLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIA 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDK--VVAVFYTVITPLLNP 222
Cdd:cd15236   199 ATiLKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKdiVASVMYTVVTPMLNP 263

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

1-222

4.67e-61

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 192.31 E-value: 4.67e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15432    39 LSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQ 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15432   119 QLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIV 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLPMD--KVVAVFYTVITPLLNP 222
Cdd:cd15432   199 RAvLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDrgKMVALFYGIITPMLNP 263

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

1-222

1.57e-60

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 191.16 E-value: 1.57e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15233    39 LGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQT 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYV-VI 159
Cdd:cd15233   119 ALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVV 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 160 LLHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15233   199 AAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSsdKDKVIGILNTVLSPMLNP 263

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

1-222

1.67e-59

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 188.46 E-value: 1.67e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15428    39 LSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15428   119 SLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRII 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRP--SATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15428   199 YTvFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPksSTSKEYDKMISVFYIIVTPMLNP 263

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

1-222

1.68e-54

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 175.37 E-value: 1.68e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15433    39 LCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQ 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15433   119 TLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVA 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRP--SATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15433   199 HAvLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPihRYSQAHGKFVSLFYTVMTPALNP 263

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

1-222

4.12e-47

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 156.68 E-value: 4.12e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15223    39 LGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFIL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15223   119 KLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFF--GPCIFIYLRPSATLPMD--KVVAVFYTVITPLLNP 222
Cdd:cd15223   199 RAvLRLASGEARSKALNTCGSHLIVILFFYtaVLVSSLTYRFGKTIPPDvhVLLSVLYILIPPALNP 265

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

1-222

3.55e-45

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 151.38 E-value: 3.55e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15952    39 LAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVIS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDtflIGLLIVANGGTLSVFCFVILL--TSYVV 158
Cdd:cd15952   119 VIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACAS---IRINIIYGLFAISVLVLDVILiaLSYVL 195

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1187837223 159 ILLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYL--RPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15952   196 ILRAvFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthRFGHNIPryIHILLANLYVVLPPMLNP 264

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

1-222

6.48e-43

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 145.51 E-value: 6.48e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15917    39 LAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGL--LIVANGGTLSVFCFVILltSYVV 158
Cdd:cd15917   119 KIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTRVNSIygLFVALLIVGFDLLFIAL--SYVL 196

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1187837223 159 ILLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLRP----SATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15917   197 ILRAvLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHrfghHVPPHVHILLANLYLLLPPMLNP 265

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

1-222

2.38e-41

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 141.66 E-value: 2.38e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15221    39 LSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDT-------FLIGLLIVanggtlsVFCFVILL 153
Cdd:cd15221   119 KIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACADItvniwygLTVALLTV-------GLDVVLIA 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837223 154 TSYVVILLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYL--RPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15221   192 VSYALILRAvFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGRHIPrhVHILLANLYVLVPPMLNP 265

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

1-222

2.54e-41

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 141.40 E-value: 2.54e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15950    39 LCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVAnGGTLSVFCFVILLT-SYVVI 159
Cdd:cd15950   119 QIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRPSSLYSIT-GSTLVVGTDSAFIAvSYGLI 197

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1187837223 160 LLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIF-IYL-RPSATLPMDK--VVAVFYTVITPLLNP 222
Cdd:cd15950   198 LRAvLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTqRFGQGVPPHTqvLLADLYLLVPPMLNP 265

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

1-193

1.18e-36

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 129.54 E-value: 1.18e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15222    39 LSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTF---LIGLLIVANggTLSVFCFVILLtSYV 157
Cdd:cd15222   119 KIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRvnsIYGLFVVLS--TMGLDSLLILL-SYV 195

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1187837223 158 VILLH-LRTRSSEGRRKALSTCASHITVVILFFGPCI 193
Cdd:cd15222   196 LILKTvLGIASREERLKALNTCVSHICAVLIFYVPMI 232

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

1-222

4.93e-35

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 125.07 E-value: 4.93e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15953    39 LCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDT---FLIGLLIvanggTLSVFCFVILL--TS 155
Cdd:cd15953   119 KLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDTtinRIYGLVV-----ALLVVGLDLLLiaLS 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837223 156 YVVILLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYL--RPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15953   194 YALIIRAvLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGIAphIHIILANLYLLVPPMLNP 265

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

1-222

1.94e-34

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 123.61 E-value: 1.94e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15951    39 LCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTF---LIGLLIVANGGTLSVFCFVIlltSYV 157
Cdd:cd15951   119 KIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADTRvsrAYGLSVAFLVGGLDVIFIAV---SYI 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223 158 VILLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYLR----PSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15951   196 QILRAvFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLThrfgHNVPPHVHILIANVYLLVPPMLNP 265

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

1-222

1.11e-30

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 113.81 E-value: 1.11e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15956    39 LAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15956   119 KAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIV 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837223 161 LH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYL----RPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15956   199 KTvLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHSVPSAAHVLLSNLYLLLPPALNP 265

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

1-222

3.22e-30

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 112.69 E-value: 3.22e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNrQACA 80
Cdd:cd15948    40 LAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATILT-NSVI 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQI-LLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVI 159
Cdd:cd15948   119 TKIGLAALARAVTLMTPLpFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFI 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1187837223 160 LLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFI----YLRPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15948   199 LRAvLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSstmhRFARHVAPHVHILLANFYLLFPPMMNP 266

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

1-222

6.90e-30

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 111.84 E-value: 6.90e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15954    39 LSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVIT 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15954   119 KAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMIL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1187837223 161 LHLRTRSS-EGRRKALSTCASHITVVILFFGPCIFIYLR-----PSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15954   199 RAVVSLSSkEARSKAFSTCTAHICAIVITYTPAFFTFFAhrfggHHITPHIHIIMANLYLLLPPMMNP 266

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

1-222

5.62e-29

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 109.51 E-value: 5.62e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:pfam13853  33 LAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTILTNPVIS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSD---TFLIGLLIVAnggTLSVFCFVILLTSYV 157
Cdd:pfam13853 113 RIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADikvNNIYGLFVVT---STFGIDSLLIVLSYG 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223 158 VILLH-LRTRSSEGRRKALSTCASHITVVILFFGPCIFIYL--RPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:pfam13853 190 LILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPplLQIMMANAYLFFPPVLNP 259

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

1-222

2.08e-27

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 105.63 E-value: 2.08e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACA 80
Cdd:cd15949    55 LSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVI 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSYVVIL 160
Cdd:cd15949   135 RIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMIL 214

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837223 161 -LHLRTRSSEGRRKALSTCASHITVVILFFGPCIFIYL----RPSATLPMDKVVAVFYTVITPLLNP 222
Cdd:cd15949   215 rVVQRLATSEARLKTFGTCVSHVCAILAFYVPIAVSSLihrfGQNVPPPTHILLANFYLLIPPMLNP 281

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

4-222

3.14e-24

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 96.60 E-value: 3.14e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   4 LSFVEICYASTTAPK-LISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVL 82
Cdd:pfam00001  26 LAVADLLFSLLTLPFwLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  83 VGIAWLGGFVHSFAQILLTFRLPFCGPNVIdhyFCDLLPLLKLACSDTFLIGLLIVAnggtlSVFCFVILLTSYVVILLH 162
Cdd:pfam00001 106 ILVIWVLALLLSLPPLLFGWTLTVPEGNVT---VCFIDFPEDLSKPVSYTLLISVLG-----FLLPLLVILVCYTLIIRT 177

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1187837223 163 LRTRSSEG--------RRKALSTCASHITVVILFFGPCIFIYLRPSATLP------MDKV--VAVFYTVITPLLNP 222
Cdd:pfam00001 178 LRKSASKQkssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDcelsrlLDKAlsVTLWLAYVNSCLNP 253

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

1-222

1.29e-20

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 87.13 E-value: 1.29e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   1 LSYLSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQaca 80
Cdd:cd15955    39 LAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAMALDRYVAICHPLRHSSILTPQ--- 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  81 VLVGIAWL----GGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPLLKLACSDTFLIGLLIVANGGTLSVFCFVILLTSY 156
Cdd:cd15955   116 VLLGIGVLvvvrAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSY 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1187837223 157 VVILLHL-RTRSSEGRRKALSTCASHITVVILFFGPCIFIYL--RPSATLP--MDKVVAVFYTVITPLLNP 222
Cdd:cd15955   196 ALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahRFGHHVApyVHILLSNLYLLVPPVLNP 266

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

4-217

6.15e-12

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 63.08 E-value: 6.15e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   4 LSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLV 83
Cdd:cd00637    40 LAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  84 GIAWLGGFVHSFAQILLTFRLPFCGPNVIDHYFCDLLPllklacSDTFLIGLLIVanggtLSVFCFVILLTSYVVILLHL 163
Cdd:cd00637   120 ALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTL------SKAYTIFLFVL-----LFLLPLLVIIVCYVRIFRKL 188

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1187837223 164 RTRSSEG---------------RRKALSTCASHITVVILFFGPCIFIYLRPSATLPMDKVVAVFYTVIT 217
Cdd:cd00637   189 RRHRRRIrssssnssrrrrrrrERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPLPRILYFLAL 257

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

24-172

3.04e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 46.82 E-value: 3.04e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  24 LAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQAcAVLVGIAWLGGFVHSFAqilltfr 103
Cdd:cd14969    62 LSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRA-LILIAFIWLYGLFWALP------- 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837223 104 lPFCGPNVI----DHYFCDLLPLLKLACSDTFLIgllivanggTLSVFCFV----ILLTSYVVILLHLRTRSSEGRR 172
Cdd:cd14969   134 -PLFGWSSYvpegGGTSCSVDWYSKDPNSLSYIV---------SLFVFCFFlplaIIIFCYYKIYRTLRKMSKRAAR 200

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

51-113

2.71e-05

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 43.76 E-value: 2.71e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837223  51 FLLTMMAYDRYVAICKPLNYTTIMNRQaCAVLVGIAWLGGFVHSFAQILLtFRLPFCGPNVID 113
Cdd:cd15196    89 YVLVATAIDRYIAICHPLSSHRWTSRR-VHLMVAIAWVLSLLLSIPQLFI-FSYQEVGSGVYD 149

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

48-95

3.90e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 43.50 E-value: 3.90e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1187837223  48 TEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLVGIAWLGGFVHSF 95
Cdd:cd15312    86 TSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAF 133

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

44-100

9.28e-05

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 42.16 E-value: 9.28e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837223  44 FFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLVGIAWLGGFVHSFAQILL 100
Cdd:cd14967    81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVG 137

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

48-98

7.02e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 39.74 E-value: 7.02e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1187837223  48 TEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLVGIAWLGGFVHSFAQI 98
Cdd:cd15317    86 TSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLI 136

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

50-105

1.05e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 39.07 E-value: 1.05e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1187837223  50 IFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLVGIAWLGGFVHSFAQILLTFRLP 105
Cdd:cd15055    88 IFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQP 143

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

51-181

1.16e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 39.28 E-value: 1.16e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  51 FLLTMMAYDRYVAICKPLNytTIMNRQACAVLVGIAWLGGFVHSFAQiLLTFRLPFCGPNVIDhyfcdllpllklaCSDT 130
Cdd:cd14986    89 YILVSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIPQ-LVIFVERELGDGVHQ-------------CWSS 152

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1187837223 131 F--LIGLLIVANGGTLSVFC--FVILLTSYVVILLHLRTRSSEGRRKALSTCASH 181
Cdd:cd14986   153 FytPWQRKVYITWLATYVFVipLIILSYCYGRILRTIWIRSRQKTDRPIAPTAMS 207

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

41-192

2.08e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 38.17 E-value: 2.08e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  41 FIHFFGGT----EIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLVGIAWLGGFVHSfAQILLTFRLpFCGPNVIDHYF 116
Cdd:cd15098    77 FVHYFFTVsmlvSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMA-SPVAVHQDL-VHHWTASNQTF 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223 117 C-------DLLPLLKLAcsdTFLIGLLIVanggtlsvfcFVILLTSYVVILLHLRTRSSEGRRKALST---CASHITVVI 186
Cdd:cd15098   155 CwenwpekQQKPVYVVC---TFVFGYLLP----------LLLITFCYAKVLNHLHKKLKNMSKKSERSkkkTAQTVLVVV 221


                  ....*.
gi 1187837223 187 LFFGPC 192
Cdd:cd15098   222 VVFGIS 227

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

34-92

2.33e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 38.22 E-value: 2.33e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1187837223  34 GCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLVgIAWLGGFV 92
Cdd:cd15075    72 GCVLEGFAVAFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIA-SSWLWSLI 129

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

50-102

2.43e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 38.18 E-value: 2.43e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1187837223  50 IFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLVGIAWLGGFVHSFAQILLTF 102
Cdd:cd15057    88 ILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGW 140

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

51-100

2.68e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 37.86 E-value: 2.68e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1187837223  51 FLLTMMAYDRYVAICKPLNYTTIMNRQACaVLVGIAWLGGFVHSFAQILL 100
Cdd:cd15386    89 YMLIMMTVDRYIAVCHPLRTLQQPSRQAY-LMIGATWLLSCILSLPQVFI 137

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

53-100

3.27e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 37.82 E-value: 3.27e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1187837223  53 LTMMAYDRYVAICKPLNYTTIMNRQACAVLVGIAWLGGFVHSFAQILL 100
Cdd:cd15058    91 LCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMN 138

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

51-97

4.24e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 37.49 E-value: 4.24e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1187837223  51 FLLTMMAYDRYVAICKPLNyTTIMNRQACAVLVGIAWLGGFVHSFAQ 97
Cdd:cd15385    89 YMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSFILSTPQ 134

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

48-189

4.72e-03

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 37.19 E-value: 4.72e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223  48 TEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLVGIAWLGGFVHSfaqilltfrLPFCGPNVIDHYFCDLL-PLLKLA 126
Cdd:cd14993    86 ASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIM---------LPLLVVYELEEIISSEPgTITIYI 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223 127 CSDTFLIGLLIVANGGTLSVFCFV----ILLTSYVVILLHLRTRSSEGRRKALSTCASH-------------ITVVILFF 189
Cdd:cd14993   157 CTEDWPSPELRKAYNVALFVVLYVlpllIISVAYSLIGRRLWRRKPPGDRGSANSTSSRrilrskkkvarmlIVVVVLFA 236

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

4-92

4.98e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 37.25 E-value: 4.98e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837223   4 LSFVEICYASTTAPKLISDLLAKRKTISLWGCMTQLFFIHFFGGTEIFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLV 83
Cdd:cd15074    42 LAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIV 121


                  ....*....
gi 1187837223  84 GIaWLGGFV 92
Cdd:cd15074   122 AI-WLYALF 129

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

50-92

6.84e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 36.85 E-value: 6.84e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1187837223  50 IFLLTMMAYDRYVAICKPLNYTTIMNRQACAVLVGIAWLGGFV 92
Cdd:cd14968    86 IFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFL 128

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01