NCBI Conserved Domain Search

Conserved domains on [gi|1187837058|gb|ARM55162|]

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olfactory receptor family 14, partial [Vampyrum spectrum]

Protein Classification

olfactory receptor family 14 protein( domain architecture ID 11607040)

olfactory receptor family 14 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

1-232

1.45e-132

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 374.10 E-value: 1.45e-132

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15227    32 HTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHYEVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15227   112 MNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFII 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15227   192 VSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLLLSVFYSVVPPTLNP 263

Name

Accession

Description

Interval

E-value

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

1-232

1.45e-132

Pssm-ID: 320355 Cd Length: 270 Bit Score: 374.10 E-value: 1.45e-132

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15227    32 HTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHYEVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15227   112 MNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFII 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15227   192 VSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLLLSVFYSVVPPTLNP 263

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

1-232

7.90e-28

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 106.82 E-value: 7.90e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:pfam13853  26 HQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:pfam13853 106 LTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLIV 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFL--LTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:pfam13853 186 LSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYtpMIGLSMVHRFGHNVPPLLQIMMANAYLFFPPVLNP 259

Name

Accession

Description

Interval

E-value

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

1-232

1.45e-132

Pssm-ID: 320355 Cd Length: 270 Bit Score: 374.10 E-value: 1.45e-132

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15227    32 HTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHYEVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15227   112 MNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFII 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15227   192 VSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLLLSVFYSVVPPTLNP 263

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

1-232

1.97e-92

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 272.43 E-value: 1.97e-92

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd13954    32 HTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAVMAYDRYVAICHPLHYPTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd13954   112 MNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNELVIFILAGFVGLGSFLLTL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd13954   192 VSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSDLDKVVSVFYTVVTPMLNP 263

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

1-232

6.90e-85

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 253.15 E-value: 6.90e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15225    32 HTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAYDRYVAICNPLRYTLI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15225   112 MNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASVLVILVPFLLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15225   192 VSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDKLLSLFYTVVTPMLNP 263

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

1-232

7.68e-84

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 250.50 E-value: 7.68e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15230    32 HTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAYDRYVAICNPLLYTVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15230   112 MSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHINELVLFAFSGFIGLSTLLIIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15230   192 ISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNP 263

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

1-232

1.47e-79

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 239.86 E-value: 1.47e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15231    32 HTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAYDRYVAICNPLHYAVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15231   112 MSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTSLNEVLLLVASVFIGLTPFLFIV 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15231   192 ISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLDKDTLISVLYSIVTPMLNP 263

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

1-232

1.11e-78

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 237.49 E-value: 1.11e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15229    32 HTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAYDRYAAICHPLHYVQI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWlnggALGILYSTG----TFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCL 156
Cdd:cd15229   112 MSKQVCVQLVGGAW----ALGFLYALIntllLLNLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLLTSSVIFGLGSF 187

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1187837058 157 VCIVVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15229   188 LLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVLDRVFSIQYSILTPMLNP 263

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

1-232

3.97e-76

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 230.90 E-value: 3.97e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15421    32 HTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLLALMAYDRYVAICHPLRYPVL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15421   112 MSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTSAYETVVYVSGVLFLLIPFSLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15421   192 ASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSPEQDKVVSVFYTILTPMLNP 263

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

1-232

5.99e-76

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 230.24 E-value: 5.99e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15237    32 HTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRYSVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15237   112 MSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEAVIFVTSVLVLLIPFSLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15237   192 ASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPDQDKMISVFYTIVTPMLNP 263

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

1-232

1.02e-73

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 224.80 E-value: 1.02e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15918    32 HTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVMAYDRYVAICHPLHYTTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15918   112 MSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHLNELVILVLGGLVGLVPFLCIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15918   192 VSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDSVAAVMYTVVTPMLNP 263

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

1-232

1.85e-73

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 224.94 E-value: 1.85e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15943    46 HTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVI 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15943   126 MSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEIL 205

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15943   206 VSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNP 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

1-232

9.65e-73

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 222.36 E-value: 9.65e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15911    32 HTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSYDRYLAICKPLHYASL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15911   112 MNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSLVELVTFILSSIVTLPPFLLTL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837058 161 VSYIHIFSTVLKIP-TRQRQsKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15911   192 TSYICIISTILRIPsTTGRQ-KAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRDLNKVFSLFYTVLTPLVNP 263

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

1-232

3.50e-71

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 218.12 E-value: 3.50e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15912    32 HTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMSFDRYVAICNPLHYPTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLnGGALGILYSTG-TFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCI 159
Cdd:cd15912   112 MNSRVCLQLVLGSWV-GGFLLILPPTIlVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRLIELLDFILASVVLLGSLLLT 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837058 160 VVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15912   191 IVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSLDLNKVVALLNTVVTPLLNP 263

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

1-232

5.63e-71

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 217.86 E-value: 5.63e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15235    33 HTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYATV 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15235   113 MSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIV 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15235   193 LSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADKDRVATVMYTVVTPMLNP 264

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

1-232

1.24e-70

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 217.18 E-value: 1.24e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15419    32 HTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAYDRFIAICNPLLYPVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15419   112 MSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTFINELVMFVLCGLIIVSTILVIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15419   192 VSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPEQSKVVSVFYTLVIPMLNP 263

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

1-232

1.95e-68

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 211.41 E-value: 1.95e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15411    32 HTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAYDRYVAICNPLLYTVV 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15411   112 MSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVNEMLIFILAGLTLVGSLLIIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15411   192 VSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDKVASVFYTVVIPMLNP 263

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

1-232

3.53e-68

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 210.96 E-value: 3.53e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15417    32 HTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAAMAYDRYVAICNPLLYSVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15417   112 MSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFISQVVLFLVAVLFGVFSVLVVL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15417   192 ISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQDKVASVFYTVVIPMLNP 263

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

1-232

4.64e-67

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 207.86 E-value: 4.64e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15947    32 HTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAVMAFDRYVAVCRPLHYTVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15947   112 MHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTTFNELELFVASVFFLLVPLSLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15947   192 VSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDQGKFISLFYTVVTPTLNP 263

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

1-232

7.03e-67

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 208.28 E-value: 7.03e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15410    45 HTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVI 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15410   125 MSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIIL 204

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15410   205 TSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNP 276

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

1-232

2.24e-66

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 206.41 E-value: 2.24e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15420    32 HTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15420   112 MNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWINEILIFAGCVFILLGPFSLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15420   192 ISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEKILSLFYSLFNPMLNP 263

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

1-232

3.31e-66

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 206.02 E-value: 3.31e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15408    45 HTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVI 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLnGGALGILYSTGT-FSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCI 159
Cdd:cd15408   125 MSQRVCVSLVAGSYL-AGFLNSTVHTGFiLRLSFCGSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVI 203

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837058 160 VVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15408   204 LISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNP 276

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

1-232

1.31e-65

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 204.52 E-value: 1.31e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15416    32 HTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAAMAYDRYVAICNPLLYSTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15416   112 MSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKILPSISSGIIILVTVLTII 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15416   192 ISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQNKVVSVFYMVVIPMLNP 263

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

1-232

1.80e-65

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 203.64 E-value: 1.80e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15232    32 HTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAYDRYVAICHPLHYSTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15232   112 MRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSLNEIMAFVADVFFGVGNFLLTL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15232   192 TSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPEKDKVVAVLYSVVTPTLNP 263

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

1-232

6.96e-64

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 199.82 E-value: 6.96e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15224    32 HKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYDRYVAICHPLRYPVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15224   112 MTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSLAELVDFILALIILLVPLLVTV 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15224   192 ASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDSNKLVSVLYTVVTPLLNP 263

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

1-232

7.62e-64

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 199.52 E-value: 7.62e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15430    32 HTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYPII 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15430   112 MNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEIIMLVGNIIFLVIPLLLIC 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15430   192 ISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISDKLITLFYGVVTPMLNP 263

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

1-232

8.82e-63

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 196.68 E-value: 8.82e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15431    32 HTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAVMAYDRFVAICNPLRYTLI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYStGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15431   112 MSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALLKLACSDTSLNEILMFATSIFTLLLPFSFIL 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15431   191 VSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQDKIISVFYGVVTPMLNP 262

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

1-232

1.25e-62

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 196.64 E-value: 1.25e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15234    32 HTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVMAYDRYVAICHPLHYTVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15234   112 MNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLINNILIYLATVIFGGIPLSGII 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15234   192 FSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSSRKTAVASVMYTVVTPMLNP 263

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

1-232

4.82e-62

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 195.31 E-value: 4.82e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15429    32 HTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLAVMAYDRYVAVCHPLRYTVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15429   112 MSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLNEVAILVSSVVVLLTPCFLVL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15429   192 LSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEKMISLFYAVVTPMLNP 263

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

1-232

1.03e-61

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 194.96 E-value: 1.03e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15945    45 HTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15945   125 MSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAII 204

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15945   205 ISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNP 276

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

1-232

1.08e-61

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 194.18 E-value: 1.08e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15424    32 HTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAYDRYLAICHPLLYAAA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15424   112 MGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHITEAIVFGAGVLILLVPLSVIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15424   192 TSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTPDRDKQIAVFYIVITPLLNP 263

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

1-232

3.85e-61

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 193.00 E-value: 3.85e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15412    32 HTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVMAYDRYMAICNPLLYSVK 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15412   112 MSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVKETAMFIVAGFNLSSSLLIIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15412   192 ISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVEQSKIVAVFYTFVSPMLNP 263

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

1-232

5.15e-61

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 192.54 E-value: 5.15e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15413    32 QTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSAMAYDRYVAICNPLLYTVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15413   112 MSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHEKELIILIFAGFNLISSLLIVL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15413   192 VSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDKMASVFYTLVIPMLNP 263

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

1-232

8.53e-61

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 192.24 E-value: 8.53e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15409    32 HTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAYDRYVAICNPLLYPVV 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVS-VAIGVCYAFSCLVcI 159
Cdd:cd15409   112 MSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSINELVLfIFSGSIQVFTILT-V 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837058 160 VVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15409   191 LISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDMMDSLFYTIVIPLLNP 263

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

1-232

9.06e-60

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 189.23 E-value: 9.06e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15432    32 HTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAVMAFDRFAAICQPLHYSVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15432   112 MHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTANEAELFVISVLLLLIPLGLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15432   192 ISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDRGKMVALFYGIITPMLNP 263

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

1-232

5.42e-59

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 187.63 E-value: 5.42e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15407    32 HTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLLASMAYDRHAAVCKPLHYTTT 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15407   112 MTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIHISEIVLFFLASFNVFFALLVIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15407   192 ISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMDTDKMASVFYTMVIPMLNP 263

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

1-232

5.76e-59

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 187.03 E-value: 5.76e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15226    32 HSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAMAFDRYVAICKPLHYLTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15226   112 MSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYVLELMVVANSGLISLVCFLLLL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRqSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPslLDLLVSVFYSVAPPTLNP 232
Cdd:cd15226   192 ISYIVILVTVRKHSSGGS-SKALSTCSAHITVVVLFFGPCIFIYVWPFSTFP--VDKFLAVFYTVITPLLNP 260

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

1-232

5.98e-59

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 187.68 E-value: 5.98e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15944    45 HTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15944   125 MSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIIL 204

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15944   205 ISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNP 276

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

1-232

6.48e-59

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 187.58 E-value: 6.48e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15406    41 HTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVT 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15406   121 MSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAIL 200

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15406   201 ISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNP 272

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

1-232

1.21e-58

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 186.43 E-value: 1.21e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15434    32 HTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAVMAYDRYAAVCQPLHYTVV 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15434   112 MHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTAYEATIFALGVFILLFPLSLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15434   192 VSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDQGKFLTLFYTIVTPSLNP 263

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

1-232

2.05e-58

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 185.59 E-value: 2.05e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15915    32 HSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAVMAYDRYVAICNPLRYTVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15915   112 MNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSLNLWLLNIVTGSIALGTFILTL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837058 161 VSYIHIFSTVLKIPTRQR-QSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15915   192 LSYIYIISFLLLKVRSKEgRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQDRIVALLYTVVTPVLNP 264

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

1-232

2.42e-58

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 185.73 E-value: 2.42e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTF-TDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEA 79
Cdd:cd15916    32 HRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPgGKVISFGGCVAQLYFFHFLGSTECFLYTLMAYDRYLAICHPLHYPT 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  80 IMSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVA-IGVCyAFSCLVC 158
Cdd:cd15916   112 IMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTTINELVIFAsIGVV-ALGCFIL 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837058 159 IVVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPslLDLLVSVFYSVAPPTLNP 232
Cdd:cd15916   191 ILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEA--LDGVIAVFYTVVTPLLNP 262

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

1-232

1.13e-57

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 183.57 E-value: 1.13e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15939    32 GSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAYDRYVAICKPLHYTTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLnggaLGILYSTG----TFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCL 156
Cdd:cd15939   112 MNRRVCGLLVGVAWV----GGFLHSTIqillTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYVIGLLVVANSGLICLLSF 187

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1187837058 157 VCIVVSYIHIFSTvLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPslLDLLVSVFYSVAPPTLNP 232
Cdd:cd15939   188 LILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFP--IDKVVAVFYTIITPMLNP 260

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

1-232

3.29e-57

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 182.68 E-value: 3.29e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15946    32 HTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMAYDRYVAICHPLRYKVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15946   112 MSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTSLNEMVDFVLGVIVLVVPLSLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15946   192 ASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSPERDKKISLFYNVFTALLNP 263

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

1-232

1.93e-56

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 180.72 E-value: 1.93e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15940    32 HTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIMAYDRYVAICNPLHYPTV 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15940   112 MNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTYLIDILIVSNSGLISLVCFVALL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQsKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPslLDLLVSVFYSVAPPTLNP 232
Cdd:cd15940   192 GSYIVILVSLRKRSTEGRR-KALSTCASHLTVVTLFFGPCIFIYTRPSTSFS--EDKVVSVFYTVVTPLLNP 260

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

1-232

2.03e-56

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 180.64 E-value: 2.03e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15914    32 HTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAMAYDRYLAICNPLHYPSI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15914   112 MTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSLNVLVDFVIHAVIILLTFLLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15914   192 LSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDRAIAVVYAVLTPFFNP 263

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

1-232

2.68e-56

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 180.35 E-value: 2.68e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15236    32 HTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAVMAYDRYVAICHPLHYTAI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15236   112 MRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLNELVIFTEGGLLFVLPLLLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15236   192 GSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIVASVMYTVVTPMLNP 263

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

1-232

4.87e-56

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 179.93 E-value: 4.87e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15414    32 HTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLLASMAYDRYVAICNPLLYTVI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHV----SVAIGVcyaFSCL 156
Cdd:cd15414   112 MSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQINKWVlfimAGALGV---LSGL 188

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1187837058 157 VcIVVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15414   189 I-ILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLDKVVSVFYTAVIPMLNP 263

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

1-232

9.12e-56

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 179.15 E-value: 9.12e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15415    32 HTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAYDRYVAICNPLLYTVA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15415   112 MTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHINELLLLTFSGVIAMSTLLTII 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15415   192 ISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQEKVSAVFYTLVIPMLNP 263

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

1-232

5.41e-55

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 176.74 E-value: 5.41e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15913    32 HTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSVMAFDRYLAICRPLHYPTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLnGGALGILYSTGTFS-LKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCI 159
Cdd:cd15913   112 MTGQLCGKLVAFCWV-CGFLWFLIPVVLISqLPFCGPNIIDHFLCDPGPLLALSCVPAPGTELICYTLSSLIIFGTFLFI 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837058 160 VVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15913   191 LGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNSTGMQKIVTLFYSVVTPLLNP 263

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

1-232

5.51e-54

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 174.58 E-value: 5.51e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15418    33 HTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAMAYDRYVAICNPLLYSSA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15418   113 MSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRVYELILYFILGFNVIAPTALIL 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15418   193 ASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDRDKVVALFYTVVNPLLNP 264

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

1-232

6.98e-54

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 174.21 E-value: 6.98e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15233    32 HTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTAMAYDRYLAICQPLTYSVR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15233   112 MSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHLNELLLFVFAFFMALAPCVLIV 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15233   192 VSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSDKDKVIGILNTVLSPMLNP 263

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

1-232

1.40e-53

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 173.29 E-value: 1.40e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15936    32 HTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15936   112 MNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFLLELLMVSNSGLVTLLIFFILL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFsTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPslLDLLVSVFYSVAPPTLNP 232
Cdd:cd15936   192 ISYTVIL-VKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFP--MDKAVSVLYTVITPMLNP 260

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

1-232

1.56e-53

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 173.43 E-value: 1.56e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15428    32 HTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLSVMSYDRYVAICLPLRYSLI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15428   112 MTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQAEMAMFIMCVFTLVLPVLLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15428   192 ASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSKEYDKMISVFYIIVTPMLNP 263

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

1-232

2.40e-53

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 172.99 E-value: 2.40e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15405    32 HTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAMAYDRYVAICNPLLYTVT 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVT-IHVSVAIGVCYAFSCLVcI 159
Cdd:cd15405   112 MSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYVNeLVVFVVVGINIIVPSVT-I 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837058 160 VVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15405   191 FISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGKVSSVFYTNVVPMLNP 263

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

2-232

4.36e-52

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 169.28 E-value: 4.36e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIM 81
Cdd:cd15938    33 SPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAYDRYVAICKPLHYTTIM 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  82 SKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIVV 161
Cdd:cd15938   113 SRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCVTELLMVSNSGLISTVCFVVLVT 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1187837058 162 SYIHIfstVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSllDLLVSVFYSVAPPTLNP 232
Cdd:cd15938   193 SYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPV--DKHVSVLYNVITPMLNP 258

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

3-232

4.49e-52

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 169.64 E-value: 4.49e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   3 PMYFLLRHLSFLDLCLISATVPKSILNYVTFT-DSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIM 81
Cdd:cd15941    35 PMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFHFLASTECFLYTVMAYDRYLAICHPLHYPTAM 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  82 SKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIVV 161
Cdd:cd15941   115 NRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTTINELVILANIGIVAAGCFLLIVI 194

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1187837058 162 SYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSllDLLVSVFYSVAPPTLNP 232
Cdd:cd15941   195 SYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQAG--AGAPAVFYTIVTPMLNP 263

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

1-232

1.54e-50

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 165.68 E-value: 1.54e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15942    32 HKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTVMAYDRFLAICKPLHYSTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15942   112 MNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTAFNELVTFIDIGLVAMTCFLLIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPslLDLLVSVFYSVAPPTLNP 232
Cdd:cd15942   192 MSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDP--LDGVVAVFYTTVTPLLNP 261

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

1-232

2.02e-50

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 165.30 E-value: 2.02e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15228    32 HTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAYDRYVAICHPLRYLLI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVS-VAIGVCyAFSCLVCI 159
Cdd:cd15228   112 MNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSIAETVSfTNVGLV-PLTCFLLI 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837058 160 VVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKpsLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15228   191 LASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSP--VLVTPVQIFNNVVTPMLNP 261

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

2-232

5.79e-50

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 164.17 E-value: 5.79e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIM 81
Cdd:cd15935    34 SPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVM 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  82 SKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIVV 161
Cdd:cd15935   114 NRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTYVVEVLMVANSGLLSLVCFLVLLV 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1187837058 162 SYIHIFSTvLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPslLDLLVSVFYSVAPPTLNP 232
Cdd:cd15935   194 SYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSS--VDKVASVFYTLITPALNP 261

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

1-232

8.90e-49

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 161.31 E-value: 8.90e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15223    32 HQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVMALDRYVAICKPLRYPSI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15223   112 ITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTTINSIYGLAVAWLIVGSDIILIF 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15223   192 FSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGKTIPPDVHVLLSVLYILIPPALNP 265

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

1-232

6.94e-46

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 153.79 E-value: 6.94e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15433    32 HTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAVMAFDRYAAVCRPLHYAAL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15433   112 MSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDETTEVQMFVARVVILLLPAALIL 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15433   192 GSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQAHGKFVSLFYTVMTPALNP 263

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

1-232

9.00e-44

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 148.21 E-value: 9.00e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15917    32 HEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15917   112 LTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTRVNSIYGLFVALLIVGFDLLFIA 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15917   192 LSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthRFGHHVPPHVHILLANLYLLLPPMLNP 265

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

2-232

2.14e-43

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 147.19 E-value: 2.14e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIM 81
Cdd:cd15937    33 SPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLVAMAYDRYVAICKPLHYTTVV 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  82 SKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIVV 161
Cdd:cd15937   113 NRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYTVELLMFSNSGLVILLCFLLLLI 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1187837058 162 SYIHIFSTvLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKPASDKPslLDLLVSVFYSVAPPTLNP 232
Cdd:cd15937   193 SYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFP--MDKVVAVFHTVIFPLLNP 260

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

1-232

8.13e-40

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 137.93 E-value: 8.13e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15950    32 HEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15950   112 LTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRPSSLYSITGSTLVVGTDSAFIA 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15950   192 VSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYtqRFGQGVPPHTQVLLADLYLLVPPMLNP 265

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

1-232

1.10e-37

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 132.47 E-value: 1.10e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15951    32 HEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIFVAMALDRYVAICNPLRHSTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15951   112 LTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADTRVSRAYGLSVAFLVGGLDVIFIA 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15951   192 VSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLthRFGHNVPPHVHILIANVYLLVPPMLNP 265

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

1-232

7.31e-37

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 130.19 E-value: 7.31e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15952    32 HQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVaIGVCYAFSCLVCIV 160
Cdd:cd15952   112 LTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASIRINIIYGL-FAISVLVLDVILIA 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15952   191 LSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthRFGHNIPRYIHILLANLYVVLPPMLNP 264

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

1-232

7.97e-37

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 130.10 E-value: 7.97e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYeai 80
Cdd:cd15221    32 HEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESAILLAMAFDRYVAICYPLRY--- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 mskgTSVLLTAVSWLNGGALGI----LYSTGTFSLK---FCGSNKIQQFFCDVPALLKLTCSEqhvtIHVSVAIGVCYAF 153
Cdd:cd15221   109 ----TTILTHSVIGKIGVAAVArsfcIVFPFVFLLKrlpYCGHNVIPHTYCEHMGIARLACAD----ITVNIWYGLTVAL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058 154 SC----LVCIVVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAP 227
Cdd:cd15221   181 LTvgldVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGRHIPRHVHILLANLYVLVP 260


                  ....*
gi 1187837058 228 PTLNP 232
Cdd:cd15221   261 PMLNP 265

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

1-232

2.60e-33

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 121.12 E-value: 2.60e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15956    32 HQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGVLVAMALDRFVAICNPLHYATI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd15956   112 LTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATTVDSLYGLALALFIGGGDVLFIA 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15956   192 YSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhRFGHSVPSAAHVLLSNLYLLLPPALNP 265

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

1-232

1.49e-32

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 119.14 E-value: 1.49e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPkSILNYVTF-TDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEA 79
Cdd:cd15222    32 HEPMYYFLSMLAVTDLGLSLSTLP-TVLGIFWFnAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYAS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  80 IMSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCI 159
Cdd:cd15222   111 ILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLI 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1187837058 160 VVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMF---LLTGAVAYlKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15222   191 LLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFyvpMIGLSMVH-RFGKHASPLVHVLMANVYLLVPPVLNP 265

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

1-232

4.44e-30

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 112.95 E-value: 4.44e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15949    48 HQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTI 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNggalGILYSTGTF----SLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCL 156
Cdd:cd15949   128 LTNTTVIRIGLAAVIR----GVLYISPLPllvrRLPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDS 203

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1187837058 157 VCIVVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15949   204 LFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAFYVPIAVSSLihRFGQNVPPPTHILLANFYLLIPPMLNP 281

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

1-232

1.07e-28

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 108.89 E-value: 1.07e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15953    32 HKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAVLVAMAFDRYVAICNPLRYATI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEqhvtIHVSVAIGVCYAFSC----L 156
Cdd:cd15953   112 LTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGD----TTINRIYGLVVALLVvgldL 187

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1187837058 157 VCIVVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15953   188 LLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGIAPHIHIILANLYLLVPPMLNP 265

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

1-232

1.61e-28

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 108.76 E-value: 1.61e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15954    32 HRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLMALDRYVAICYPLRYATI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHV-TIHVSVAIGVCYAFSCLvCI 159
Cdd:cd15954   112 LTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIRVdAIYGLMVALLIGGFDIL-CI 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1187837058 160 VVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYLKP---ASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15954   191 SVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHrfgGHHITPHIHIIMANLYLLLPPMMNP 266

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

1-232

4.97e-28

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 107.30 E-value: 4.97e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15948    33 HEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATI 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MskgTSVLLTAVSWLNGGALGILYSTGTFSLK---FCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLV 157
Cdd:cd15948   113 L---TNSVITKIGLAALARAVTLMTPLPFLLRrlpYCRSHVIAHCYCEHMAVVKLACGDTRFNNIYGIAVALFIVGLDLM 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837058 158 CIVVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15948   190 FIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhRFARHVAPHVHILLANFYLLFPPMMNP 266

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

1-232

7.90e-28

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 106.82 E-value: 7.90e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:pfam13853  26 HQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:pfam13853 106 LTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLIV 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFL--LTGAVAYLKPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:pfam13853 186 LSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYtpMIGLSMVHRFGHNVPPLLQIMMANAYLFFPPVLNP 259

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

1-232

2.68e-25

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 99.84 E-value: 2.68e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15955    32 HQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAMALDRYVAICHPLRHSSI 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALgILYSTGTFS--LKFCGSNKIQQFFCDVPALLKLTCSEqhvtIHVSVAIGVCYAFSCLVC 158
Cdd:cd15955   112 LTPQVLLGIGVLVVVRAVVL-IIPCPLLIKlrLHHFRSTVISHSYCEHMAVVKLAADD----VRVNKIYGLFVAFSILGF 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058 159 ----IVVSYIHIFSTVLKIPTRQRQSKAFSTCLPHLLVVSMFLLTGAVAYL--KPASDKPSLLDLLVSVFYSVAPPTLNP 232
Cdd:cd15955   187 diifITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahRFGHHVAPYVHILLSNLYLLVPPVLNP 266

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

1-232

1.24e-24

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 97.75 E-value: 1.24e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVT-FTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEA 79
Cdd:pfam00001  16 RTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  80 IMSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNkiqQFFCDVPALLKLTCSEqhvtIHVSVAIGVCYAFSCLVcI 159
Cdd:pfam00001  96 RRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPV----SYTLLISVLGFLLPLLV-I 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058 160 VVSYIHIFSTVLKIPTRQRQS-------KAFSTCLPHLLVVSM----FLLTGAVAYLKPASDKPSLLD--LLVSVFYSVA 226
Cdd:pfam00001 168 LVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILcwlpYHIVNLLDSLALDCELSRLLDkaLSVTLWLAYV 247


                  ....*.
gi 1187837058 227 PPTLNP 232
Cdd:pfam00001 248 NSCLNP 253

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

1-180

3.16e-15

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 72.71 E-value: 3.16e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd00637    30 RTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRR 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGILYSTGTFSLKFCGSNKIQQFFCDvpallkltcsEQHVTIHVSVAIGVCYAFsCLVCIV 160
Cdd:cd00637   110 FTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPD----------LTLSKAYTIFLFVLLFLL-PLLVII 178

                         170       180
                  ....*....|....*....|
gi 1187837058 161 VSYIHIFSTVLKIPTRQRQS 180
Cdd:cd00637   179 VCYVRIFRKLRRHRRRIRSS 198

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

1-199

2.31e-08

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 52.95 E-value: 2.31e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd14967    31 RTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWlnggalgiLYSTGTFSLKFCGSNKIQQFFCDVPallklTCSEQHVTIHVSVAIGVCYAFSCLVCIV 160
Cdd:cd14967   111 MTKKRALIMIAAVW--------VYSLLISLPPLVGWRDETQPSVVDC-----ECEFTPNKIYVLVSSVISFFIPLLIMIV 177

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1187837058 161 VsYIHIFSTVlkiptrQRQSKAFSTClphLLVVSMFLLT 199
Cdd:cd14967   178 L-YARIFRVA------RRELKAAKTL---AIIVGAFLLC 206

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

1-181

4.63e-07

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 49.51 E-value: 4.63e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYeAI 80
Cdd:cd14969    32 RTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKA-FR 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGIlystgtfsLKFCGSNKIqqffcdVPALLKLTCS---EQHVTIHVS--VAIGV-CYAFS 154
Cdd:cd14969   111 LSKRRALILIAFIWLYGLFWAL--------PPLFGWSSY------VPEGGGTSCSvdwYSKDPNSLSyiVSLFVfCFFLP 176

                         170       180
                  ....*....|....*....|....*..
gi 1187837058 155 cLVCIVVSYIHIFSTVLKIPTRQRQSK 181
Cdd:cd14969   177 -LAIIIFCYYKIYRTLRKMSKRAARRK 202

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

1-119

2.57e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 47.35 E-value: 2.57e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTftdSISFLG---CAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHY 77
Cdd:cd15312    32 HSPTNFLILSLAITDFLLGFLVMPYSMVRSVE---SCWYFGdlfCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHY 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837058  78 EAIMSKGTSVLLTAVSWLnggaLGILYStgtFSLKFCGSNKI 119
Cdd:cd15312   109 RTKITTPVIKVFLVISWS----VPCLFA---FGVVFSEVNLE 143

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

2-97

1.47e-05

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 44.73 E-value: 1.47e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAiM 81
Cdd:cd15073    33 TPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPDLGRK-M 111

                          90
                  ....*....|....*.
gi 1187837058  82 SKGTSVLLTAVSWLNG 97
Cdd:cd15073   112 TTNTYTVMILLAWTNA 127

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

1-116

3.92e-05

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 43.38 E-value: 3.92e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDL--CLISaTVPKSILNyVTFTDSISFLGC-AVQLFLVVLMAGSEIgILTAMSYDRYVAICRPLHY 77
Cdd:cd15196    32 LSRMHLFILHLSVADLlvALFN-VLPQLIWD-ITYRFYGGDLLCrLVKYLQVVGMYASSY-VLVATAIDRYIAICHPLSS 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1187837058  78 EAIMSKgTSVLLTAVSWlnggALGILYST---GTFSLKFCGS 116
Cdd:cd15196   109 HRWTSR-RVHLMVAIAW----VLSLLLSIpqlFIFSYQEVGS 145

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

6-95

4.68e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 43.25 E-value: 4.68e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   6 FLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGT 85
Cdd:cd15063    37 LFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKR 116

                          90
                  ....*....|
gi 1187837058  86 SVLLTAVSWL 95
Cdd:cd15063   117 AKCLIAGVWV 126

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

42-95

6.06e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 42.93 E-value: 6.06e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837058  42 CAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGTSVLLTAVSWL 95
Cdd:cd15055    73 CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWF 126

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

2-101

8.79e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 42.66 E-value: 8.79e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLISATVPKSILNyvTFTDSISFLG---CAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYE 78
Cdd:cd14997    33 TPTNIFLVNLSVADLLVLLVCMPVALVE--TWAREPWLLGefmCKLVPFVELTVAHASVLTILAISFERYYAICHPLQAK 110

                          90       100
                  ....*....|....*....|...
gi 1187837058  79 AIMSKGTSVLLTAVSWLNGGALG 101
Cdd:cd14997   111 YVCTKRRALVIIALIWLLALLTS 133

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

5-95

9.46e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 42.30 E-value: 9.46e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   5 YFLLRhLSFLDLCLISATVPKSILNYVTFTD-SISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSK 83
Cdd:cd15052    37 YFLMS-LAIADLLVGLLVMPLSILTELFGGVwPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSR 115

                          90
                  ....*....|..
gi 1187837058  84 GTSVLLTAVSWL 95
Cdd:cd15052   116 TTVFLKIAIVWL 127

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

42-103

1.06e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 42.36 E-value: 1.06e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1187837058  42 CAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGTSVLLTAVSWLNGGALGIL 103
Cdd:cd15104    73 CLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFL 134

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

11-95

2.17e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 41.28 E-value: 2.17e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  11 LSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGTSVLLT 90
Cdd:cd15058    42 LACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIV 121


                  ....*
gi 1187837058  91 AVSWL 95
Cdd:cd15058   122 CVVWI 126

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

2-102

3.12e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 40.94 E-value: 3.12e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIM 81
Cdd:cd15386    33 SRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMFASTYMLIMMTVDRYIAVCHPLRTLQQP 112

                          90       100
                  ....*....|....*....|.
gi 1187837058  82 SKGTSVLLtAVSWLNGGALGI 102
Cdd:cd15386   113 SRQAYLMI-GATWLLSCILSL 132

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

42-95

4.10e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 40.59 E-value: 4.10e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1187837058  42 CAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGTSVLLTAVSWL 95
Cdd:cd15306    74 CPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWL 127

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

2-104

6.09e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 40.12 E-value: 6.09e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIM 81
Cdd:cd15012    32 TITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLL 111

                          90       100
                  ....*....|....*....|...
gi 1187837058  82 SKGTSVLLTAVSWLNGGALGILY 104
Cdd:cd15012   112 TAARLRVTIVTVWLTSAVYNTPY 134

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

3-95

9.26e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 39.57 E-value: 9.26e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   3 PMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPlHYEAIMS 82
Cdd:cd15074    34 PAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTAISIYRYLKICHP-PYGPKLS 112

                          90
                  ....*....|...
gi 1187837058  83 KGTSVLLTAVSWL 95
Cdd:cd15074   113 RRHVCIVIVAIWL 125

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

1-102

9.43e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 39.53 E-value: 9.43e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTftdSISFLG---CAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHY 77
Cdd:cd15314    32 HTPTNYLILSLAVADLLVGGLVMPPSMVRSVE---TCWYFGdlfCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLLY 108

                          90       100
                  ....*....|....*....|....*
gi 1187837058  78 EAIMSKGTSVLLTAVSWLNGGALGI 102
Cdd:cd15314   109 RSKITVRVVLVMILISWSVSALVGF 133

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

1-95

9.79e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 39.28 E-value: 9.79e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFL-VVLMAGSEIgILTAMSYDRYVAICRPLHyea 79
Cdd:cd14986    32 RSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLqVVGLFASTY-ILVSMSLDRYQAIVKPMS--- 107

                          90
                  ....*....|....*...
gi 1187837058  80 iMSKG--TSVLLTAVSWL 95
Cdd:cd14986   108 -SLKPrkRARLMIVVAWV 124

7tmA_GPR61_GPR62-like

cd15220

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...

10-110

9.86e-04

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.

Pssm-ID: 410633 [Multi-domain] Cd Length: 264 Bit Score: 39.36 E-value: 9.86e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  10 HLSFLDLCLISATVPKSILNYVTFTDSISF--LGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGTSV 87
Cdd:cd15220    38 HLCVVDLLAALLLMPLGILSSSPFFLGVVFgeAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVA 117

                          90       100
                  ....*....|....*....|...
gi 1187837058  88 LLTAVSWLNGGALGILYSTGTFS 110
Cdd:cd15220   118 AVLVGVWVKALLLGLLPVLGWPS 140

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

1-96

1.24e-03

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 39.24 E-value: 1.24e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15083    32 RTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVR 111

                          90
                  ....*....|....*.
gi 1187837058  81 MSKGTSVLLTAVSWLN 96
Cdd:cd15083   112 ISHRRALIVIAVVWLY 127

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

60-167

1.42e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 38.87 E-value: 1.42e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  60 LTAMSYDRYVAICRPLHYEAIMSKGTSVLLTAVSWLNGGALGILystgTFSLKFCGSNKIQQFFCDVPALLKLTCSEQHV 139
Cdd:cd15065    90 LCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFL----PIHLGWHRLSQDEIKGLNHASNPKPSCALDLN 165

                          90       100
                  ....*....|....*....|....*...
gi 1187837058 140 TIHVSVAIGVCYAFSCLVCIVVsYIHIF 167
Cdd:cd15065   166 PTYAVVSSLISFYIPCLVMLLI-YSRLY 192

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

1-75

1.47e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 39.03 E-value: 1.47e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPL 75
Cdd:cd15387    32 HSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPL 106

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

37-103

1.69e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 38.78 E-value: 1.69e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1187837058  37 ISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGTSVLLTAVSWLNGGALGIL 103
Cdd:cd14968    66 TNFHGCLFMACLVLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLT 132

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

2-95

1.70e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 38.56 E-value: 1.70e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAim 81
Cdd:cd15197    33 SRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQ-- 110

                          90
                  ....*....|....
gi 1187837058  82 SKGTSVLLTAVSWL 95
Cdd:cd15197   111 SGRQARVLICVAWI 124

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

2-95

1.84e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 38.71 E-value: 1.84e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLIsATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAiM 81
Cdd:cd15079    33 TPSNMLVVNLAISDFLMM-IKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNP-L 110

                          90
                  ....*....|....
gi 1187837058  82 SKGTSVLLTAVSWL 95
Cdd:cd15079   111 TRGKALLLILFIWL 124

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

1-102

2.93e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 37.71 E-value: 2.93e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSIlnYVTFTDSISFLG---CAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHY 77
Cdd:cd15053    32 QTATNYFIVSLAVADLLVAILVMPFAV--YVEVNGGKWYLGpilCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKY 109

                          90       100
                  ....*....|....*....|....*
gi 1187837058  78 EAIMSKGTSVLLTAVSWLNGGALGI 102
Cdd:cd15053   110 ARQKNSKRVLLTIAIVWVVSAAIAC 134

7tmA_GPR39

cd15135

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...

33-108

3.43e-03

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.

Pssm-ID: 320263 [Multi-domain] Cd Length: 320 Bit Score: 37.85 E-value: 3.43e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1187837058  33 FTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAImSKGTSVLLTAVSWLNGG--ALGILYSTGT 108
Cdd:cd15135    69 FATPSGNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKAL-SGSRVRLLICFVWLTSAlvALPLLFAMGT 145

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

1-95

3.63e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 37.53 E-value: 3.63e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVtftDSISFLG---CAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHY 77
Cdd:cd15318    32 HTPTNFLLLSLALADMLLGLTVLPFSTIRSV---ESCWYFGdsfCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLLY 108

                          90
                  ....*....|....*...
gi 1187837058  78 EAIMSKGTSVLLTAVSWL 95
Cdd:cd15318   109 PSKFTIRVACIFIAAGWL 126

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

1-103

3.66e-03

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 37.66 E-value: 3.66e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDlCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd14972    30 HKPMYILIANLAAAD-LLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLLAIAVDRYISIVHGLTYVNN 108

                          90       100
                  ....*....|....*....|...
gi 1187837058  81 MSKGTSVLLTAVSWLNGGALGIL 103
Cdd:cd14972   109 VTNKRVKVLIALVWVWSVLLALL 131

7tmA_NTSR2

cd15356

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...

11-95

3.67e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320478 [Multi-domain] Cd Length: 285 Bit Score: 37.54 E-value: 3.67e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058  11 LSFLDLCLISATVPKSILNYVTFTDSISF--LGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGTSVL 88
Cdd:cd15356    45 LALSDLLILLISVPIELYNFVWFHYPWVFgdLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKW 124


                  ....*..
gi 1187837058  89 LTAVSWL 95
Cdd:cd15356   125 LLALIWA 131

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

41-103

3.90e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 37.58 E-value: 3.90e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1187837058  41 GCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGTSVLLTAVSWLNGGALGIL 103
Cdd:cd15959    72 VCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFL 134

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

50-95

4.43e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 37.36 E-value: 4.43e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1187837058  50 VLMAGSEIGILTAMSYDRYVAICRPLHYEAIMSKGTSVLLTAVSWL 95
Cdd:cd15066    80 VYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWI 125

7tmA_NTSR

cd15130

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

1-102

5.09e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320258 [Multi-domain] Cd Length: 281 Bit Score: 37.23 E-value: 5.09e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISF--LGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYE 78
Cdd:cd15130    35 QSTVRYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFgdAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAK 114

                          90       100
                  ....*....|....*....|....
gi 1187837058  79 AIMSKGTSVLLTAVSWLNGGALGI 102
Cdd:cd15130   115 TLMSRSRTKKFISAIWLASALLAI 138

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

1-100

5.22e-03

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 37.44 E-value: 5.22e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSI-SFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEA 79
Cdd:cd15005    32 HRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHRFYAK 111

                          90       100
                  ....*....|....*....|.
gi 1187837058  80 IMSKGTSVLLTAVSWLNGGAL 100
Cdd:cd15005   112 RMTFWTCLAVICMAWTLSVAM 132

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

1-95

5.77e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 37.04 E-value: 5.77e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYV-----------TFTDSISFLGCAVQLFLVVLMAgseigiltamsYDRYV 69
Cdd:cd15317    32 HSPTNMLVLSLATADFLLGLCVMPFSMIRTVetcwyfgdlfcKFHTGLDLLLCTTSIFHLCFIA-----------IDRYY 100

                          90       100
                  ....*....|....*....|....*.
gi 1187837058  70 AICRPLHYEAIMSKGTSVLLTAVSWL 95
Cdd:cd15317   101 AVCDPLRYPSKITVQVAWRFIAIGWL 126

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

1-104

6.43e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 37.08 E-value: 6.43e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCL----ISATVPKSILNYVTFTDSISFLGCAVQLF--LVVLMAGSEIGILTAMSYDRYVAICRP 74
Cdd:cd15103    32 HSPMYFFICSLAVADMLVsvsnALETIVIILLNNGYLVPRDSFEQHIDNVIdsMICSSLLASICSLLAIAVDRYITIFYA 111

                          90       100       110
                  ....*....|....*....|....*....|
gi 1187837058  75 LHYEAIMSKGTSVLLTAVSWLNGGALGILY 104
Cdd:cd15103   112 LRYHSIMTVRRAGVIITAIWVFCTVCGILF 141

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

2-102

6.88e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 36.83 E-value: 6.88e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   2 SPMYFLLRHLSFLDLCLISATVPKSILNYVTFtdSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAIM 81
Cdd:cd15069    33 TPTNYFLVSLAAADVAVGLFAIPFAITISLGF--CTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLV 110

                          90       100
                  ....*....|....*....|.
gi 1187837058  82 SKGTSVLLTAVSWLNGGALGI 102
Cdd:cd15069   111 TGKRARGVIAVLWVLAFGIGL 131

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

1-95

9.66e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 36.31 E-value: 9.66e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYVTFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEAI 80
Cdd:cd15062    32 RTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTI 111

                          90
                  ....*....|....*
gi 1187837058  81 MSKGTSVLLTAVSWL 95
Cdd:cd15062   112 VTARRATVALLIVWV 126

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

1-95

9.71e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 36.56 E-value: 9.71e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187837058   1 HSPMYFLLRHLSFLDLCLISATVPKSILNYV-TFTDSISFLGCAVQLFLVVLMAGSEIGILTAMSYDRYVAICRPLHYEA 79
Cdd:cd14979    32 RTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKT 111

                          90
                  ....*....|....*.
gi 1187837058  80 IMSKGTSVLLTAVSWL 95
Cdd:cd14979   112 LVTKRRVKRFILAIWL 127

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01