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Conserved domains on  [gi|118601894|ref|NP_001073118|]
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WD repeat domain-containing protein 83 [Bos taurus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-295 7.97e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.94  E-value: 7.97e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVA 97
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDcrSRKPEPVQTLDEARDGISSVKVSDHE--VLAGSVDGRV 175
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 176 RRYDLRMGQLFSDYVG--SPITCICFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYTGHKNkeYKLDCCLSERDTHVVSC 253
Cdd:cd00200  160 KLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFSPDGYLLASG 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 118601894 254 SEDGKVFFWDLVEGALALALPVGPGVVQSLTYHPTEPCLLTA 295
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-295 7.97e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.94  E-value: 7.97e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVA 97
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDcrSRKPEPVQTLDEARDGISSVKVSDHE--VLAGSVDGRV 175
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 176 RRYDLRMGQLFSDYVG--SPITCICFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYTGHKNkeYKLDCCLSERDTHVVSC 253
Cdd:cd00200  160 KLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFSPDGYLLASG 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 118601894 254 SEDGKVFFWDLVEGALALALPVGPGVVQSLTYHPTEPCLLTA 295
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
16-307 2.30e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.13  E-value: 2.30e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEVLA-GSVDG 173
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSpDGRLLAsGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 174 RVRRYDLRMGQLFSDYVG--SPITCICFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYTGHKNKEYKLdcCLSERDTHV 250
Cdd:COG2319  269 TVRLWDLATGELLRTLTGhsGGVNSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTL 345

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 118601894 251 VSCSEDGKVFFWDLVEGALALALPVGPGVVQSLTYHPTEPCLLTA-MGGSIQCWREET 307
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGsADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 28-307 5.34e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 66.65  E-value: 5.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  28 VRAVRFNVDGNYCLTCGSDKTLKLWNPlrGTLLRTYSGHGYEVLDAAGSFDNSSLC----------SGGGDKAVVLWDVA 97
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFEC--ESIIKDGRDIHYPVVELASRSKLSGICwnsyiksqvaSSNFEGVVQVWDVA 563

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  98 SGQVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSTIRCWDCrsRKPEPVQTLdEARDGISSVKV---SDHEVLAGSVDG 173
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSI--NQGVSIGTI-KTKANICCVQFpseSGRSLAFGSADH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 174 RVRRYDLRMGQL-FSDYVGSPITcICFSR--DGQCTLVSSLDSTLRLLDKDTG------ELLGEYTGHKNkeYKLDCCLS 244
Cdd:PLN00181 641 KVYYYDLRNPKLpLCTMIGHSKT-VSYVRfvDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTN--VKNFVGLS 717

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118601894 245 ERDTHVVSCSEDGKVFFWDlvegaLALALPvgpgvVQSLTYHPTEPCLLTAMGGSIQ-----CWREET 307
Cdd:PLN00181 718 VSDGYIATGSETNEVFVYH-----KAFPMP-----VLSYKFKTIDPVSGLEVDDASQfissvCWRGQS 775
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 7.96e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 7.96e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 118601894    98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 6.90e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 6.90e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 118601894   99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-295 7.97e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.94  E-value: 7.97e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  18 LKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVA 97
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDcrSRKPEPVQTLDEARDGISSVKVSDHE--VLAGSVDGRV 175
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 176 RRYDLRMGQLFSDYVG--SPITCICFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYTGHKNkeYKLDCCLSERDTHVVSC 253
Cdd:cd00200  160 KLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFSPDGYLLASG 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 118601894 254 SEDGKVFFWDLVEGALALALPVGPGVVQSLTYHPTEPCLLTA 295
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
16-307 2.30e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.13  E-value: 2.30e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEVLA-GSVDG 173
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSpDGRLLAsGSADG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 174 RVRRYDLRMGQLFSDYVG--SPITCICFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYTGHKNKEYKLdcCLSERDTHV 250
Cdd:COG2319  269 TVRLWDLATGELLRTLTGhsGGVNSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTL 345

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 118601894 251 VSCSEDGKVFFWDLVEGALALALPVGPGVVQSLTYHPTEPCLLTA-MGGSIQCWREET 307
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGsADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
12-304 2.64e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.03  E-value: 2.64e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  12 ELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAV 91
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  92 VLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEVLA-G 169
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSpDGKLLAsG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 170 SVDGRVRRYDLRMGQLFSDYVG--SPITCICFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYTGHKNKEYKLdcCLSER 246
Cdd:COG2319  223 SADGTVRLWDLATGKLLRTLTGhsGSVRSVAFSPDGR-LLASgSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSPD 299

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 118601894 247 DTHVVSCSEDGKVFFWDLVEGALALALPVGPGVVQSLTYHPTEPCLLTA-MGGSIQCWR 304
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGsDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
24-303 2.16e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.54  E-value: 2.16e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  24 GQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVR 103
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 104 KFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDcrSRKPEPVQTLDEARDGISSVKVS-DHEVLA-GSVDGRVRRYDLR 181
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTSVAFSpDGKLLAsGSDDGTVRLWDLA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 182 MGQLFSDYVG--SPITCICFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYTGHKNKEYKLDccLSERDTHVVSCSEDGK 258
Cdd:COG2319  193 TGKLLRTLTGhtGAVRSVAFSPDGK-LLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSVA--FSPDGRLLASGSADGT 269

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 118601894 259 VFFWDLVEGALALALPVGPGVVQSLTYHPTEPCLLTA-MGGSIQCW 303
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGsDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-217 6.73e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 6.73e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDCRSRKpePVQTLDEARDGISSVKVSDHE--VLAGSVDG 173
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK--CLGTLRGHENGVNSVAFSPDGylLASGSEDG 241

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 118601894 174 RVRRYDLRMGQLFSDYVG--SPITCICFSRDGQCTLVSSLDSTLRL 217
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGhtNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-309 2.04e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 2.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  59 LLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDc 138
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 139 rSRKPEPVQTLDEARDGISSVKVSDHE--VLAGSVDGRVRRYDLRMGQLFSDYVG--SPITCICFSRDGQCTLVSSLDST 214
Cdd:cd00200   80 -LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVASSSQDGT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 215 LRLLDKDTGELLGEYTGHKNkeYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGPGVVQSLTYHPTEPCLLT 294
Cdd:cd00200  159 IKLWDLRTGKCVATLTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                        250
                 ....*....|....*.
gi 118601894 295 A-MGGSIQCWREETYE 309
Cdd:cd00200  237 GsEDGTIRVWDLRTGE 252
WD40 COG2319
WD40 repeat [General function prediction only];
15-181 2.97e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 2.97e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  15 QKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLW 94
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  95 DVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDCRSRKpePVQTLDEARDGISSVKVS-DHEVLA-GSVD 172
Cdd:COG2319  316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSpDGRTLAsGSAD 393


                 ....*....
gi 118601894 173 GRVRRYDLR 181
Cdd:COG2319  394 GTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
32-304 1.70e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 1.70e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  32 RFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGK 111
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 112 VNTVQFNEEATVILSGSIDSTIRCWDCRSrkPEPVQTLDEARDGISSVKVS-DHEVLA-GSVDGRVRRYDLRMGQLFSDY 189
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLAT--GLLLRTLTGHTGAVRSVAFSpDGKTLAsGSADGTVRLWDLATGKLLRTL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 190 VG--SPITCICFSRDGQcTLVS-SLDSTLRLLDKDTGELLGEYTGHKNKEYKLdcCLSERDTHVVSCSEDGKVFFWDLVE 266
Cdd:COG2319  159 TGhsGAVTSVAFSPDGK-LLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLWDLAT 235

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 118601894 267 GALALALPVGPGVVQSLTYHPTEPCLLTAMG-GSIQCWR 304
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-137 2.61e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.72  E-value: 2.61e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:cd00200  168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 118601894  96 VASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWD 137
Cdd:cd00200  248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 28-307 5.34e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 66.65  E-value: 5.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  28 VRAVRFNVDGNYCLTCGSDKTLKLWNPlrGTLLRTYSGHGYEVLDAAGSFDNSSLC----------SGGGDKAVVLWDVA 97
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFEC--ESIIKDGRDIHYPVVELASRSKLSGICwnsyiksqvaSSNFEGVVQVWDVA 563

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  98 SGQVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSTIRCWDCrsRKPEPVQTLdEARDGISSVKV---SDHEVLAGSVDG 173
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSI--NQGVSIGTI-KTKANICCVQFpseSGRSLAFGSADH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 174 RVRRYDLRMGQL-FSDYVGSPITcICFSR--DGQCTLVSSLDSTLRLLDKDTG------ELLGEYTGHKNkeYKLDCCLS 244
Cdd:PLN00181 641 KVYYYDLRNPKLpLCTMIGHSKT-VSYVRfvDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTN--VKNFVGLS 717

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118601894 245 ERDTHVVSCSEDGKVFFWDlvegaLALALPvgpgvVQSLTYHPTEPCLLTAMGGSIQ-----CWREET 307
Cdd:PLN00181 718 VSDGYIATGSETNEVFVYH-----KAFPMP-----VLSYKFKTIDPVSGLEVDDASQfissvCWRGQS 775
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 7.96e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 7.96e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 118601894    98 SGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWD 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-137 6.90e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 6.90e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 118601894   99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWD 137
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 14-53 2.82e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.82e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 118601894    14 PQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWN 53
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
16-53 5.65e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.65e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 118601894   16 KRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWN 53
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 222-263 1.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 118601894   222 TGELLGEYTGHKNkeYKLDCCLSERDTHVVSCSEDGKVFFWD 263
Cdd:smart00320   1 SGELLKTLKGHTG--PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
57-95 2.36e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.36e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 118601894   57 GTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-95 4.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.59e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 118601894    57 GTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWD 95
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 44-189 7.38e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 7.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  44 GSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAG----------KVN 113
Cdd:PTZ00421 145 GADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrclwakRKD 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 114 TVqfneeATVILSGSIDSTIRCWDCRsRKPEPVQTLDEARDGISSVKVSDHE----VLAGSVDGRVRRYDLRMGQLFSDY 189
Cdd:PTZ00421 225 LI-----ITLGCSKSQQRQIMLWDTR-KMASPYSTVDLDQSSALFIPFFDEDtnllYIGSKGEGNIRCFELMNERLTFCS 298
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 99-217 2.62e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894   99 GQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDC-RSRKPE--------------------PVQTLDEARDGIS 157
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlRGRSSEkrsrntqtefprkdhviaetPFHILCGHDDIIT 193

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  158 SVKVSdHE---VLAGSVDGRVRRYDLRMGQlfsdYV-------GSPITCICFSRDGQCTLVSSLDSTLRL 217
Cdd:pfam20426 194 CLYVS-VEldiVISGSKDGTCIFHTLREGR----YVrsirhpsGCPLSKLVASRHGRIVLYADDDLSLHL 258
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 118-226 3.35e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 38.75  E-value: 3.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894 118 NEEATVILSGSIDSTIRCWDCRS-RKP--------EPVQTLDEARDGissvkvsdHEVLAGSVDGRVRRYDLRMGQLFSD 188
Cdd:cd22857  189 KDDHRKIVTGTGYHQVRLYDTRAqRRPvvsvdfgeTPIKAVAEDPDG--------HTVYVGDTSGDLASIDLRTGKLLGC 260

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 118601894 189 YVG---SPITCIcfSRDGQCTLVSS--LDSTLRLLDKDTGELL 226
Cdd:cd22857  261 FKGkcgGSIRSI--ARHPELPLIAScgLDRYLRIWDTETRQLL 301
PTZ00421 PTZ00421
coronin; Provisional
 24-142 4.79e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.34  E-value: 4.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118601894  24 GQ-GAVRAVRFN-VDGNYCLTCGSDKTLKLWN-PLRGTLLRTYS------GHGYEVldAAGSFDNSS---LCSGGGDKAV 91
Cdd:PTZ00421  73 GQeGPIIDVAFNpFDPQKLFTASEDGTIMGWGiPEEGLTQNISDpivhlqGHTKKV--GIVSFHPSAmnvLASAGADMVV 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 118601894  92 VLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSTIRCWDCRSRK 142
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201
WD40 pfam00400
WD domain, G-beta repeat;
223-263 5.26e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 5.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 118601894  223 GELLGEYTGHKNKEYklDCCLSERDTHVVSCSEDGKVFFWD 263
Cdd:pfam00400   1 GKLLKTLEGHTGSVT--SLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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