NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|118572663|sp|P46013|]
View 

RecName: Full=Proliferation marker protein Ki-67; AltName: Full=Antigen identified by monoclonal antibody Ki-67; Short=Antigen KI-67; Short=Antigen Ki67

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1001-1112 8.97e-56

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 189.73  E-value: 8.97e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1001 KITKMPCQSLQPEPINTPTHTKQQLKASLGKVGVKEELLAVGKFTRTSGETTHTHREPAGDGKSIRTFKESPKQILDPAA 1080
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1081 RVTGMKKWPRTPKEEAQSLEDLAGFKELFQTP 1112
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1367-1477 3.50e-54

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 185.50  E-value: 3.50e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1367 KTTKMPCESSPPESADTPTSTRRQPKTPLEKRDVQKELSALKKLTQTSGETTHTDKVPGGEDKSINAFRETAKQKLDPAA 1446
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1447 SVTGSKRHPKT-KEKAQPLEDLAGLKELFQTP 1477
Cdd:pfam08065   81 NVTGSKRRPRTpKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1123-1234 1.11e-52

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 181.26  E-value: 1.11e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1123 KTTKIACKSPPPESVDTPTSTKQWPKRSLRKADVEEEFLALRKLTPSAGKAMLTPKPAGGDEKDIKAFMGTPVQKLDLAG 1202
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1203 TLPGSKRQLQTPKEKAQALEDLAGFKELFQTP 1234
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2097-2204 3.21e-52

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 179.72  E-value: 3.21e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2097 KTTKIACKSPPPESMDTPTSTRRRPKTPLGKRDIVEELSALKQLTQT----THTDKVPGDEDKGINVFRETAKQKLDPAA 2172
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTpgetTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2173 SVTGSKRQPRTPKGKAQPLEDLAGLKELFQTP 2204
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1975-2086 1.52e-51

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 177.79  E-value: 1.52e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1975 KITEVSCKSPQPDPVKTPTSSKQRLKISLGKVGVKEEVLPVGKLTQTSGKTTQTHRETAGDGKSIKAFKESAKQMLDPAN 2054
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2055 YGTGMERWPRTPKEEAQSLEDLAGFKELFQTP 2086
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2215-2326 3.03e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 173.94  E-value: 3.03e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2215 KTTKIACRSPQPDPVGTPTIFKPQSKRSLRKADVEEESLALRKRTPSVGKAMDTPKPAGGDEKDMKAFMGTPVQKLDLPG 2294
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2295 NLPGSKRWPQTPKEKAQALEDLAGFKELFQTP 2326
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1245-1356 4.97e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 173.55  E-value: 4.97e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1245 KTTKIPCDSPQSDPVDTPTSTKQRPKRSIRKADVEGELLACRNLMPSAGKAMHTPKPSVGEEKDIIIFVGTPVQKLDLTE 1324
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1325 NLTGSKRRPQTPKEEAQALEDLTGFKELFQTP 1356
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2336-2447 6.92e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 173.17  E-value: 6.92e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2336 KTTKIACKSPQPDPVDTPASTKQRPKRNLRKADVEEEFLALRKRTPSAGKAMDTPKPAVSDEKNINTFVETPVQKLDLLG 2415
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2416 NLPGSKRQPQTPKEKAEALEDLVGFKELFQTP 2447
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1488-1597 8.56e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 172.78  E-value: 8.56e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1488 KTTKIACRS-QPDPVDTPTSSKPQSKRSLRKVDVEEEFFALRKRTPSAGKAMHTPKPAVSGEKNIYAFMGTPVQKLDLTE 1566
Cdd:pfam08065    1 KTTKMPCKSpQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 118572663  1567 NLTGSKRRLQTPKEKAQALEDLAGFKELFQT 1597
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQT 111
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2819-2928 1.08e-48

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 169.70  E-value: 1.08e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2819 KTTKIPCKSS-PELEDTATSSKRRPRTRAQKVEVKEELLAVGKLTQTSGETTHTDKEPVGEGKGTKAFKQPAKRKLD-AE 2896
Cdd:pfam08065    1 KTTKMPCKSPqPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDpAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2897 DVIGSRRQPRAPKEKAQPLEDLASFQELSQTP 2928
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2458-2569 6.41e-48

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 167.39  E-value: 6.41e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2458 KITEVSCKSPQPESFKTSRSSKQRLKIPLVKVDMKEEPLAVSKLTRTSGETTQTHTEPTGDSKSIKAFKESPKQILDPAA 2537
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2538 SVTGSRRQLRTRKEKARALEDLVDFKELFSAP 2569
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1852-1964 1.30e-47

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 166.62  E-value: 1.30e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1852 KTTKkILCKSPQSDPADTPTNTKQRPKRSLKKADVEEEFLAFRKLTPSAGKAMHTPKAAVGEEKDINTFVGTPVEKLDLL 1931
Cdd:pfam08065    1 KTTK-MPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPA 79

                           90       100       110
                   ....*....|....*....|....*....|...
gi 118572663  1932 GNLPGSKRRPQTPKEKAKALEDLAGFKELFQTP 1964
Cdd:pfam08065   80 ENVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1731-1842 3.92e-44

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 156.61  E-value: 3.92e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1731 KTTKVSYRASQPDLVDTPTSSKPQPKRSLRKADTEEEFLAFRKQTPSAGKAMHTPKPAVGEEKDINTFLGTPVQKLDQPG 1810
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1811 NLPGSNRRLQTRKEKAQALEELTGFRELFQTP 1842
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
 6-98 5.57e-44

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


:

Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 155.45  E-value: 5.57e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    6 RLVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQ-EAILHNFSSTNPTQVNGSVIDEPVRLKH 84
Cdd:cd22673     2 KLVVIKKDGTDGSRFPLTKKSCTFGRDLSCDIRIQLPGVSREHCRIEVDENgKAYLENLSTTNPTLVNGKAIEKSAELKD 81

                          90
                  ....*....|....
gi 118572663   85 GDVITIIDRSFRYE 98
Cdd:cd22673    82 GDVITIGGRSFRFE 95
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1609-1720 4.74e-43

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 153.52  E-value: 4.74e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1609 KTAKVACKSSQPDPDKNPASSKRRLKTSLGKVGVKEELLAVGKLTQTSGETTHTHTEPTGDGKSMKAFMESPKQILDSAA 1688
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1689 SLTGSKRQLRTPKGKSEVPEDLAGFIELFQTP 1720
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2580-2688 2.12e-41

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 148.90  E-value: 2.12e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2580 KNTKIPCKSPPPELTDTATSTKRCPKTRPRK-EVKEELSAVERLTQTSGQSTHTHKEPASGDEGIKVLKQRAKKKPNPVE 2658
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKvDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 118572663  2659 EEP-SRRRPRAPKEKAQPLEDLAGFTELSET 2688
Cdd:pfam08065   81 NVTgSKRRPRTPKEKAQPLEDLAGFKELFQT 111
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2700-2804 2.16e-40

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


:

Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 145.82  E-value: 2.16e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2700 KATKIPCESPPLEVVDTTASTKRHLRTRVQKVQVKEEPSAV-KFTQTSGETTDADKEPAGEDKGIKALKESAKQTPAPAA 2778
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALrKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100
                   ....*....|....*....|....*.
gi 118572663  2779 SVTGSRRRPRAPRESAQAIEDLAGFK 2804
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFK 106
PP1_bind super family cl21128
Protein phosphatase 1 binding; This domain contains a protein phosphatase 1 (PP1) binding site.
 502-557 6.98e-10

Protein phosphatase 1 binding; This domain contains a protein phosphatase 1 (PP1) binding site.


The actual alignment was detected with superfamily member pfam15276:

Pssm-ID: 434590 [Multi-domain]  Cd Length: 62  Bit Score: 57.07  E-value: 6.98e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 118572663   502 KRRRVSFGGHLRPELFDENLPPNTPLKRGEAPTKRKSLVMHTPP-VLKKIIKEQ-PQP 557
Cdd:pfam15276    1 KKKRVTFGEDLSPEVFDESLPANTPLRKGGTPARKKDPSNTSPPpPLQSPVPEAlPQP 58
 
Name Accession Description Interval E-value
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1001-1112 8.97e-56

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 189.73  E-value: 8.97e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1001 KITKMPCQSLQPEPINTPTHTKQQLKASLGKVGVKEELLAVGKFTRTSGETTHTHREPAGDGKSIRTFKESPKQILDPAA 1080
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1081 RVTGMKKWPRTPKEEAQSLEDLAGFKELFQTP 1112
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1367-1477 3.50e-54

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 185.50  E-value: 3.50e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1367 KTTKMPCESSPPESADTPTSTRRQPKTPLEKRDVQKELSALKKLTQTSGETTHTDKVPGGEDKSINAFRETAKQKLDPAA 1446
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1447 SVTGSKRHPKT-KEKAQPLEDLAGLKELFQTP 1477
Cdd:pfam08065   81 NVTGSKRRPRTpKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1123-1234 1.11e-52

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 181.26  E-value: 1.11e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1123 KTTKIACKSPPPESVDTPTSTKQWPKRSLRKADVEEEFLALRKLTPSAGKAMLTPKPAGGDEKDIKAFMGTPVQKLDLAG 1202
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1203 TLPGSKRQLQTPKEKAQALEDLAGFKELFQTP 1234
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2097-2204 3.21e-52

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 179.72  E-value: 3.21e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2097 KTTKIACKSPPPESMDTPTSTRRRPKTPLGKRDIVEELSALKQLTQT----THTDKVPGDEDKGINVFRETAKQKLDPAA 2172
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTpgetTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2173 SVTGSKRQPRTPKGKAQPLEDLAGLKELFQTP 2204
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1975-2086 1.52e-51

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 177.79  E-value: 1.52e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1975 KITEVSCKSPQPDPVKTPTSSKQRLKISLGKVGVKEEVLPVGKLTQTSGKTTQTHRETAGDGKSIKAFKESAKQMLDPAN 2054
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2055 YGTGMERWPRTPKEEAQSLEDLAGFKELFQTP 2086
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2215-2326 3.03e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 173.94  E-value: 3.03e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2215 KTTKIACRSPQPDPVGTPTIFKPQSKRSLRKADVEEESLALRKRTPSVGKAMDTPKPAGGDEKDMKAFMGTPVQKLDLPG 2294
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2295 NLPGSKRWPQTPKEKAQALEDLAGFKELFQTP 2326
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1245-1356 4.97e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 173.55  E-value: 4.97e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1245 KTTKIPCDSPQSDPVDTPTSTKQRPKRSIRKADVEGELLACRNLMPSAGKAMHTPKPSVGEEKDIIIFVGTPVQKLDLTE 1324
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1325 NLTGSKRRPQTPKEEAQALEDLTGFKELFQTP 1356
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2336-2447 6.92e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 173.17  E-value: 6.92e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2336 KTTKIACKSPQPDPVDTPASTKQRPKRNLRKADVEEEFLALRKRTPSAGKAMDTPKPAVSDEKNINTFVETPVQKLDLLG 2415
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2416 NLPGSKRQPQTPKEKAEALEDLVGFKELFQTP 2447
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1488-1597 8.56e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 172.78  E-value: 8.56e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1488 KTTKIACRS-QPDPVDTPTSSKPQSKRSLRKVDVEEEFFALRKRTPSAGKAMHTPKPAVSGEKNIYAFMGTPVQKLDLTE 1566
Cdd:pfam08065    1 KTTKMPCKSpQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 118572663  1567 NLTGSKRRLQTPKEKAQALEDLAGFKELFQT 1597
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQT 111
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2819-2928 1.08e-48

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 169.70  E-value: 1.08e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2819 KTTKIPCKSS-PELEDTATSSKRRPRTRAQKVEVKEELLAVGKLTQTSGETTHTDKEPVGEGKGTKAFKQPAKRKLD-AE 2896
Cdd:pfam08065    1 KTTKMPCKSPqPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDpAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2897 DVIGSRRQPRAPKEKAQPLEDLASFQELSQTP 2928
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2458-2569 6.41e-48

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 167.39  E-value: 6.41e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2458 KITEVSCKSPQPESFKTSRSSKQRLKIPLVKVDMKEEPLAVSKLTRTSGETTQTHTEPTGDSKSIKAFKESPKQILDPAA 2537
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2538 SVTGSRRQLRTRKEKARALEDLVDFKELFSAP 2569
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1852-1964 1.30e-47

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 166.62  E-value: 1.30e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1852 KTTKkILCKSPQSDPADTPTNTKQRPKRSLKKADVEEEFLAFRKLTPSAGKAMHTPKAAVGEEKDINTFVGTPVEKLDLL 1931
Cdd:pfam08065    1 KTTK-MPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPA 79

                           90       100       110
                   ....*....|....*....|....*....|...
gi 118572663  1932 GNLPGSKRRPQTPKEKAKALEDLAGFKELFQTP 1964
Cdd:pfam08065   80 ENVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1731-1842 3.92e-44

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 156.61  E-value: 3.92e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1731 KTTKVSYRASQPDLVDTPTSSKPQPKRSLRKADTEEEFLAFRKQTPSAGKAMHTPKPAVGEEKDINTFLGTPVQKLDQPG 1810
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1811 NLPGSNRRLQTRKEKAQALEELTGFRELFQTP 1842
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
 6-98 5.57e-44

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 155.45  E-value: 5.57e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    6 RLVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQ-EAILHNFSSTNPTQVNGSVIDEPVRLKH 84
Cdd:cd22673     2 KLVVIKKDGTDGSRFPLTKKSCTFGRDLSCDIRIQLPGVSREHCRIEVDENgKAYLENLSTTNPTLVNGKAIEKSAELKD 81

                          90
                  ....*....|....
gi 118572663   85 GDVITIIDRSFRYE 98
Cdd:cd22673    82 GDVITIGGRSFRFE 95
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1609-1720 4.74e-43

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 153.52  E-value: 4.74e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1609 KTAKVACKSSQPDPDKNPASSKRRLKTSLGKVGVKEELLAVGKLTQTSGETTHTHTEPTGDGKSMKAFMESPKQILDSAA 1688
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1689 SLTGSKRQLRTPKGKSEVPEDLAGFIELFQTP 1720
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2580-2688 2.12e-41

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 148.90  E-value: 2.12e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2580 KNTKIPCKSPPPELTDTATSTKRCPKTRPRK-EVKEELSAVERLTQTSGQSTHTHKEPASGDEGIKVLKQRAKKKPNPVE 2658
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKvDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 118572663  2659 EEP-SRRRPRAPKEKAQPLEDLAGFTELSET 2688
Cdd:pfam08065   81 NVTgSKRRPRTPKEKAQPLEDLAGFKELFQT 111
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2700-2804 2.16e-40

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 145.82  E-value: 2.16e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2700 KATKIPCESPPLEVVDTTASTKRHLRTRVQKVQVKEEPSAV-KFTQTSGETTDADKEPAGEDKGIKALKESAKQTPAPAA 2778
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALrKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100
                   ....*....|....*....|....*.
gi 118572663  2779 SVTGSRRRPRAPRESAQAIEDLAGFK 2804
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFK 106
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
6-98 5.73e-20

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 86.94  E-value: 5.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    6 RLVtIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHG 85
Cdd:COG1716     3 RLV-VLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNGQRVTEPAPLRDG 81

                          90
                  ....*....|...
gi 118572663   86 DVITIIDRSFRYE 98
Cdd:COG1716    82 DVIRLGKTELRFR 94
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 27-90 4.92e-16

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 74.92  E-value: 4.92e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 118572663    27 CLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAI-LHNFSSTNPTQVNGSVI-DEPVRLKHGDVITI 90
Cdd:pfam00498    1 VTIGRSPDCDIVLDDPSVSRRHAEIRYDGGGRFyLEDLGSTNGTFVNGQRLgPEPVRLKDGDVIRL 66
PP1_bind pfam15276
Protein phosphatase 1 binding; This domain contains a protein phosphatase 1 (PP1) binding site.
 502-557 6.98e-10

Protein phosphatase 1 binding; This domain contains a protein phosphatase 1 (PP1) binding site.


Pssm-ID: 434590 [Multi-domain]  Cd Length: 62  Bit Score: 57.07  E-value: 6.98e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 118572663   502 KRRRVSFGGHLRPELFDENLPPNTPLKRGEAPTKRKSLVMHTPP-VLKKIIKEQ-PQP 557
Cdd:pfam15276    1 KKKRVTFGEDLSPEVFDESLPANTPLRKGGTPARKKDPSNTSPPpPLQSPVPEAlPQP 58
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 29-76 1.45e-08

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 52.95  E-value: 1.45e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 118572663     29 FGRGIE-CDIRIQLPVVSKQHCKIEIHEQ-EAILHNFSSTNPTQVNGSVI 76
Cdd:smart00240    3 IGRSSEdCDIQLDGPSISRRHAVIVYDGGgRFYLIDLGSTNGTFVNGKRI 52
 
Name Accession Description Interval E-value
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1001-1112 8.97e-56

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 189.73  E-value: 8.97e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1001 KITKMPCQSLQPEPINTPTHTKQQLKASLGKVGVKEELLAVGKFTRTSGETTHTHREPAGDGKSIRTFKESPKQILDPAA 1080
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1081 RVTGMKKWPRTPKEEAQSLEDLAGFKELFQTP 1112
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1367-1477 3.50e-54

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 185.50  E-value: 3.50e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1367 KTTKMPCESSPPESADTPTSTRRQPKTPLEKRDVQKELSALKKLTQTSGETTHTDKVPGGEDKSINAFRETAKQKLDPAA 1446
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1447 SVTGSKRHPKT-KEKAQPLEDLAGLKELFQTP 1477
Cdd:pfam08065   81 NVTGSKRRPRTpKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1123-1234 1.11e-52

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 181.26  E-value: 1.11e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1123 KTTKIACKSPPPESVDTPTSTKQWPKRSLRKADVEEEFLALRKLTPSAGKAMLTPKPAGGDEKDIKAFMGTPVQKLDLAG 1202
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1203 TLPGSKRQLQTPKEKAQALEDLAGFKELFQTP 1234
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2097-2204 3.21e-52

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 179.72  E-value: 3.21e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2097 KTTKIACKSPPPESMDTPTSTRRRPKTPLGKRDIVEELSALKQLTQT----THTDKVPGDEDKGINVFRETAKQKLDPAA 2172
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTpgetTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2173 SVTGSKRQPRTPKGKAQPLEDLAGLKELFQTP 2204
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1975-2086 1.52e-51

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 177.79  E-value: 1.52e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1975 KITEVSCKSPQPDPVKTPTSSKQRLKISLGKVGVKEEVLPVGKLTQTSGKTTQTHRETAGDGKSIKAFKESAKQMLDPAN 2054
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2055 YGTGMERWPRTPKEEAQSLEDLAGFKELFQTP 2086
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2215-2326 3.03e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 173.94  E-value: 3.03e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2215 KTTKIACRSPQPDPVGTPTIFKPQSKRSLRKADVEEESLALRKRTPSVGKAMDTPKPAGGDEKDMKAFMGTPVQKLDLPG 2294
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2295 NLPGSKRWPQTPKEKAQALEDLAGFKELFQTP 2326
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1245-1356 4.97e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 173.55  E-value: 4.97e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1245 KTTKIPCDSPQSDPVDTPTSTKQRPKRSIRKADVEGELLACRNLMPSAGKAMHTPKPSVGEEKDIIIFVGTPVQKLDLTE 1324
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1325 NLTGSKRRPQTPKEEAQALEDLTGFKELFQTP 1356
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2336-2447 6.92e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 173.17  E-value: 6.92e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2336 KTTKIACKSPQPDPVDTPASTKQRPKRNLRKADVEEEFLALRKRTPSAGKAMDTPKPAVSDEKNINTFVETPVQKLDLLG 2415
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2416 NLPGSKRQPQTPKEKAEALEDLVGFKELFQTP 2447
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1488-1597 8.56e-50

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 172.78  E-value: 8.56e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1488 KTTKIACRS-QPDPVDTPTSSKPQSKRSLRKVDVEEEFFALRKRTPSAGKAMHTPKPAVSGEKNIYAFMGTPVQKLDLTE 1566
Cdd:pfam08065    1 KTTKMPCKSpQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 118572663  1567 NLTGSKRRLQTPKEKAQALEDLAGFKELFQT 1597
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQT 111
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2819-2928 1.08e-48

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 169.70  E-value: 1.08e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2819 KTTKIPCKSS-PELEDTATSSKRRPRTRAQKVEVKEELLAVGKLTQTSGETTHTDKEPVGEGKGTKAFKQPAKRKLD-AE 2896
Cdd:pfam08065    1 KTTKMPCKSPqPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDpAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2897 DVIGSRRQPRAPKEKAQPLEDLASFQELSQTP 2928
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2458-2569 6.41e-48

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 167.39  E-value: 6.41e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2458 KITEVSCKSPQPESFKTSRSSKQRLKIPLVKVDMKEEPLAVSKLTRTSGETTQTHTEPTGDSKSIKAFKESPKQILDPAA 2537
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  2538 SVTGSRRQLRTRKEKARALEDLVDFKELFSAP 2569
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1852-1964 1.30e-47

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 166.62  E-value: 1.30e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1852 KTTKkILCKSPQSDPADTPTNTKQRPKRSLKKADVEEEFLAFRKLTPSAGKAMHTPKAAVGEEKDINTFVGTPVEKLDLL 1931
Cdd:pfam08065    1 KTTK-MPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPA 79

                           90       100       110
                   ....*....|....*....|....*....|...
gi 118572663  1932 GNLPGSKRRPQTPKEKAKALEDLAGFKELFQTP 1964
Cdd:pfam08065   80 ENVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1731-1842 3.92e-44

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 156.61  E-value: 3.92e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1731 KTTKVSYRASQPDLVDTPTSSKPQPKRSLRKADTEEEFLAFRKQTPSAGKAMHTPKPAVGEEKDINTFLGTPVQKLDQPG 1810
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1811 NLPGSNRRLQTRKEKAQALEELTGFRELFQTP 1842
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
 6-98 5.57e-44

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 155.45  E-value: 5.57e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    6 RLVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQ-EAILHNFSSTNPTQVNGSVIDEPVRLKH 84
Cdd:cd22673     2 KLVVIKKDGTDGSRFPLTKKSCTFGRDLSCDIRIQLPGVSREHCRIEVDENgKAYLENLSTTNPTLVNGKAIEKSAELKD 81

                          90
                  ....*....|....
gi 118572663   85 GDVITIIDRSFRYE 98
Cdd:cd22673    82 GDVITIGGRSFRFE 95
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 1609-1720 4.74e-43

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 153.52  E-value: 4.74e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  1609 KTAKVACKSSQPDPDKNPASSKRRLKTSLGKVGVKEELLAVGKLTQTSGETTHTHTEPTGDGKSMKAFMESPKQILDSAA 1688
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 118572663  1689 SLTGSKRQLRTPKGKSEVPEDLAGFIELFQTP 1720
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFKELFQTP 112
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2580-2688 2.12e-41

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 148.90  E-value: 2.12e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2580 KNTKIPCKSPPPELTDTATSTKRCPKTRPRK-EVKEELSAVERLTQTSGQSTHTHKEPASGDEGIKVLKQRAKKKPNPVE 2658
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKvDVEEELSALRKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 118572663  2659 EEP-SRRRPRAPKEKAQPLEDLAGFTELSET 2688
Cdd:pfam08065   81 NVTgSKRRPRTPKEKAQPLEDLAGFKELFQT 111
KI67R pfam08065
KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this ...
 2700-2804 2.16e-40

KI67R (NUC007) repeat; This family represents the KI67/Chmadrin repeat. The function of this repeat is unknown.


Pssm-ID: 462351 [Multi-domain]  Cd Length: 112  Bit Score: 145.82  E-value: 2.16e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663  2700 KATKIPCESPPLEVVDTTASTKRHLRTRVQKVQVKEEPSAV-KFTQTSGETTDADKEPAGEDKGIKALKESAKQTPAPAA 2778
Cdd:pfam08065    1 KTTKMPCKSPQPEPVNTPTSRKRQLKTSLGKVDVEEELSALrKPTQTPGETTHTPKEPEGDDKDIKLFKETPKQKLDPAE 80

                           90       100
                   ....*....|....*....|....*.
gi 118572663  2779 SVTGSRRRPRAPRESAQAIEDLAGFK 2804
Cdd:pfam08065   81 NVTGSKRRPRTPKEKAQPLEDLAGFK 106
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 8-98 3.05e-24

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 99.27  E-value: 3.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    8 VTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHGDV 87
Cdd:cd00060     2 LIVLDGDGGGREFPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGGGVYLEDLGSTNGTFVNGKRITPPVPLQDGDV 81

                          90
                  ....*....|.
gi 118572663   88 ITIIDRSFRYE 98
Cdd:cd00060    82 IRLGDTTFRFE 92
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
6-98 5.73e-20

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 86.94  E-value: 5.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    6 RLVtIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHG 85
Cdd:COG1716     3 RLV-VLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNGQRVTEPAPLRDG 81

                          90
                  ....*....|...
gi 118572663   86 DVITIIDRSFRYE 98
Cdd:COG1716    82 DVIRLGKTELRFR 94
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 27-90 4.92e-16

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 74.92  E-value: 4.92e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 118572663    27 CLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAI-LHNFSSTNPTQVNGSVI-DEPVRLKHGDVITI 90
Cdd:pfam00498    1 VTIGRSPDCDIVLDDPSVSRRHAEIRYDGGGRFyLEDLGSTNGTFVNGQRLgPEPVRLKDGDVIRL 66
FHA_DgcB-like cd22682
forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB ...
 8-98 7.11e-15

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.


Pssm-ID: 438734 [Multi-domain]  Cd Length: 96  Bit Score: 72.56  E-value: 7.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    8 VTIKRSG--VDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVR--LK 83
Cdd:cd22682     1 ALLMIIGppGVGKQFPITESTIVIGRSVESQVQIDDDSVSRYHAKLAVNPSAVSIIDLGSTNGTIVNGKKIPKLAScdLQ 80

                          90
                  ....*....|....*
gi 118572663   84 HGDVITIIDRSFRYE 98
Cdd:cd22682    81 NGDQIKIGNTIFKFH 95
FHA_CHFR cd22672
forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains ...
 13-99 1.50e-10

forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains protein (CHFR); CHFR, also called RING finger protein 196 (RNF196), is a checkpoint protein that delays entry into mitosis in response to stress. It functions as an E3 ubiquitin ligase that ubiquitinates and degrades its target proteins, such as Aurora-A, Plk1, Kif22 and PARP-1, which are critical for proper mitotic transitions. It also plays an important role in cell cycle progression and tumor suppression and is negatively regulated by SUMOylation-mediated proteasomal ubiquitylation. Moreover, CHFR is involved in the early stage of the DNA damage response, which mediates the crosstalk between ubiquitination and poly-ADP-ribosylation. CHFR contains a fork head associated-(FHA) domain and a RING-HC finger. The CHFR FHA domain has been crystallized as a segment-swapped dimer. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438724 [Multi-domain]  Cd Length: 108  Bit Score: 60.77  E-value: 1.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663   13 SGVDGPHFPLSLSTCLFGRGIECDIRI---QLpvVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVI--DEPVRLKHGDV 87
Cdd:cd22672     9 TEESSPPILLRKDEFTIGRAKDCDLSFpgnKL--VSGDHCKIIRDEKGQVWLEDTSTNGTLVNKVKVvkGQKVELKHGDV 86

                          90       100
                  ....*....|....*....|
gi 118572663   88 ITIIDR--------SFRYEN 99
Cdd:cd22672    87 IYLVYRkndpeqnvAYLFQS 106
FHA_MEK1-like cd22670
forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine ...
 9-90 6.66e-10

forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438722 [Multi-domain]  Cd Length: 105  Bit Score: 58.78  E-value: 6.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    9 TIKRSGVDGPHFPLSLST---CLFGRGIECDIRIQLPVVSKQHCKIE-IHEQEAILHNFS----STNPTQVNGSVIDE-- 78
Cdd:cd22670     3 KLEVSSPGSTDIVLPIYKnqvITIGRSPSCDIVINDPFVSRTHCRIYsVQFDESSAPLVYvedlSSNGTYLNGKLIGRnn 82

                          90
                  ....*....|..
gi 118572663   79 PVRLKHGDVITI 90
Cdd:cd22670    83 TVLLSDGDVIEI 94
PP1_bind pfam15276
Protein phosphatase 1 binding; This domain contains a protein phosphatase 1 (PP1) binding site.
 502-557 6.98e-10

Protein phosphatase 1 binding; This domain contains a protein phosphatase 1 (PP1) binding site.


Pssm-ID: 434590 [Multi-domain]  Cd Length: 62  Bit Score: 57.07  E-value: 6.98e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 118572663   502 KRRRVSFGGHLRPELFDENLPPNTPLKRGEAPTKRKSLVMHTPP-VLKKIIKEQ-PQP 557
Cdd:pfam15276    1 KKKRVTFGEDLSPEVFDESLPANTPLRKGGTPARKKDPSNTSPPpPLQSPVPEAlPQP 58
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
 6-92 3.91e-09

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 56.08  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    6 RLVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEP---VRL 82
Cdd:cd22665     2 RLKVFSQAHGPEKDFPLYEGENVIGRDPSCSVVLPDKSVSKQHACIEVDGGTHLIEDLGSTNGTRIGNKVRLKPnvrYEL 81

                          90
                  ....*....|
gi 118572663   83 KHGDVITIID 92
Cdd:cd22665    82 IDGDLLLFGD 91
FHA_FhaA-like cd22668
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
 20-90 5.32e-09

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438720 [Multi-domain]  Cd Length: 91  Bit Score: 55.55  E-value: 5.32e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 118572663   20 FPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHGDVITI 90
Cdd:cd22668    13 YQLREGSNIIGRGSDADFRLPDTGVSRRHAEIRWDGQVAHLTDLGSTNGTTVNNAPVTPEWRLADGDVITL 83
COG3456 COG3456
Predicted component of the type VI protein secretion system, contains a FHA domain [Signal ...
 29-90 5.47e-09

Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442679 [Multi-domain]  Cd Length: 402  Bit Score: 61.32  E-value: 5.47e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118572663   29 FGRGIECDIRIQLP--VVSKQHCKIEIHEQEAILHNfSSTNPTQVNGSVI----DEPVRLKHGDVITI 90
Cdd:COG3456    30 IGRSADCDWVLPDPdrSVSRRHAEIRFRDGAFCLTD-LSTNGTFLNGSDHplgpGRPVRLRDGDRLRI 96
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 29-76 1.45e-08

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 52.95  E-value: 1.45e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 118572663     29 FGRGIE-CDIRIQLPVVSKQHCKIEIHEQ-EAILHNFSSTNPTQVNGSVI 76
Cdd:smart00240    3 IGRSSEdCDIQLDGPSISRRHAVIVYDGGgRFYLIDLGSTNGTFVNGKRI 52
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
 17-90 3.30e-08

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 53.42  E-value: 3.30e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 118572663    17 GPH----FPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEP-VRLKHGDVITI 90
Cdd:pfam16697    5 GPHagaeFPLEGGRYRIGSDPDCDIVLSDKEVSRVHLKLEVDDEGWRLDDLGSGNGTLVNGQRVTELgIALRPGDRIEL 83
FHA_EspA-like cd22698
forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA ...
 6-98 1.49e-07

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438750 [Multi-domain]  Cd Length: 93  Bit Score: 51.64  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    6 RLVTIKRSG-VDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEpVRLKH 84
Cdd:cd22698     1 PLILIEQKGsEEGKDYELDQDEFTIGRSSNNDIRLNDHSVSRHHARIVRQGDKCNLTDLGSTNGTFLNGIRVGT-HELKH 79

                          90
                  ....*....|....
gi 118572663   85 GDVITIIDRSFRYE 98
Cdd:cd22698    80 GDRIQLGETIFRFI 93
FHA_ArnA-like cd22680
forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing ...
 7-90 2.55e-07

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438732 [Multi-domain]  Cd Length: 96  Bit Score: 51.19  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    7 LVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSV-IDEPVRLKHG 85
Cdd:cd22680     3 LEILSSPNLTGKKFPFDFSSVSIGRDPENVIVIPDPFVSRNHARITVDSNEIYIEDLGSTNGTFVNDFKrIKGPAKLHPN 82


                  ....*
gi 118572663   86 DVITI 90
Cdd:cd22680    83 DIIKL 87
FHA_KIF16 cd22708
forkhead associated (FHA) domain found in the kinesin-like protein KIF16 family; The KIF16 ...
 29-89 3.99e-07

forkhead associated (FHA) domain found in the kinesin-like protein KIF16 family; The KIF16 family includes StARD9/KIF16A and KIF16B. StARD9, also called START domain-containing protein 9, or kinesin-like protein KIF16A, is a microtubule-dependent motor protein required for spindle pole assembly during mitosis. It is required to stabilize the pericentriolar material (PCM). KIF16B, also called sorting nexin-23, is a plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. It regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). It regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.


Pssm-ID: 438760 [Multi-domain]  Cd Length: 109  Bit Score: 50.73  E-value: 3.99e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118572663   29 FGRG---IECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTnPTQVNGSVIDEPVRLKHGDVIT 89
Cdd:cd22708    35 IGREdapQEQDIVLDGEDIEAEHCIIENVGGVVTLHPLPGA-LCAVNGQVITQPTRLTQGDVIL 97
FHA_FHAD1 cd22700
forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 ...
 20-88 4.40e-07

forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins; FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438752 [Multi-domain]  Cd Length: 96  Bit Score: 50.33  E-value: 4.40e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 118572663   20 FPLSLSTCLFGRGiECDIRIQLPVVSKQHCKIEIHEQEA--ILHNFSSTNPTQVNGSVI-DEPVRLKHGDVI 88
Cdd:cd22700    11 FQLDPKVTTIGRE-GCDLVLQSPGVEEQHAVIEYSEQENcfVLQDLNTAQGTYVNDCRIqNAAVRLAPGDVL 81
FHA_FhaB-like cd22693
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
 17-90 7.47e-07

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaB and similar proteins; FhaB, also called FtsZ-interacting protein A (FipA), is a putative virulence factor involved in regulating cell shape. It can interact with polyketide-associated protein PapA5, a putative membrane protein involved in the biosynthesis of virulence enhancing lipids. FhaB regulates growth and cell division. It is probably required for divisomal protein assembly under oxidative stress. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438745 [Multi-domain]  Cd Length: 91  Bit Score: 49.61  E-value: 7.47e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118572663   17 GPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHGDVITI 90
Cdd:cd22693    10 GQTFPIDKSGITIGRADDNDLVLSDDFVSSRHARIYLQGSSWYLEDLGSTNGTFVNGNRVTQPVVVQPGDTIRI 83
FHA_RAD53-like_rpt2 cd22690
second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine ...
 6-92 1.95e-06

second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the second one. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438742 [Multi-domain]  Cd Length: 105  Bit Score: 48.83  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    6 RLVTIKRSGvdgPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKI-EIHEQEAILHNF---SSTNPTQVNGSVIDEPVR 81
Cdd:cd22690     3 RLKSLNPSY---PDIELTQNTTFIGRSKDCDEEITDPRISKHHCIItRKRSGKGLDDVYvtdTSTNGTFINNNRLGKGSQ 79

                          90
                  ....*....|...
gi 118572663   82 --LKHGDVITIID 92
Cdd:cd22690    80 slLQDGDEIVLIW 92
FHA_Rv1747-like_rpt2 cd22737
second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
 8-98 2.20e-06

second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the second FHA domain, which has a circularly permuted FHA domain fold with a conserved pThr-binding interface.


Pssm-ID: 439356 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 2.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    8 VTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVrLKHGDV 87
Cdd:cd22737     4 MKITRPDGDTLTFELPPQAVRIGRASDNDIVIPEGSVSRHHATLVPTPGGTQIRDLRSTNGTFVNGLRVDAAL-LHDGDV 82

                          90
                  ....*....|.
gi 118572663   88 ITIIDRSFRYE 98
Cdd:cd22737    83 VTIGDIDFVFE 93
FHA_PML1-like cd22681
forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 ...
 25-94 2.44e-06

forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 (PML1) and similar proteins; PML1 is an FHA domain-containing protein required for efficient splicing and pre-mRNA nuclear retention. It is a component of the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3, and PML1. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438733 [Multi-domain]  Cd Length: 129  Bit Score: 49.36  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663   25 STCLFGRGIE-------CDIRIQLPVVSKQHCKIEIHEQEAILH----NFSSTNPTQVNGSVIDEP--VRLKHGDVITII 91
Cdd:cd22681    40 SCYLIGREKGesteivvADIGIPEETCSKQHCVIQFRNVKGILKpyimDLDSSNGTCLNDNVIPSSryVELRSGDVITFS 119


                  ...
gi 118572663   92 DRS 94
Cdd:cd22681   120 KSN 122
FHA_Cep170 cd22704
forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) ...
 16-88 4.59e-05

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438756 [Multi-domain]  Cd Length: 102  Bit Score: 45.00  E-value: 4.59e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 118572663   16 DGPHFPLSLSTCLFGRGiECDIRIQLPVVSKQHCKI--EIHEQEAILHNFSSTNPTQVNGSVIDE--PVRLKHGDVI 88
Cdd:cd22704     8 DGTRHRLPRSMLFVGRE-DCDLILQSRSVDKQHAVItyDQIDNEFKIKDLGSLNGTFVNDSRIPEqtYITLKLGDSI 83
FHA_KIF13 cd22706
forkhead associated (FHA) domain found in the kinesin-like protein KIF13 family; The KIF13 ...
 34-88 7.86e-05

forkhead associated (FHA) domain found in the kinesin-like protein KIF13 family; The KIF13 family includes KIF13A and KIF13B. KIF13A, also called kinesin-like protein RBKIN, is a plus end-directed microtubule-dependent motor protein involved in intracellular transport and in regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis, and cytokinesis. It mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, KIF13A is required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. It is also required for the abscission step in cytokinesis: it mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. KIF13B, also called kinesin-like protein GAKIN, is a novel kinesin-like protein that associates with the human homolog of the Drosophila discs large tumor suppressor in T lymphocytes. It is involved in reorganization of the cortical cytoskeleton. It regulates axon formation by promoting the formation of extra axons. KIF13B may be functionally important for the intracellular trafficking of membrane-associated guanylate kinase homologs (MAGUKs) and associated protein complexes. The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.


Pssm-ID: 438758 [Multi-domain]  Cd Length: 101  Bit Score: 44.21  E-value: 7.86e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 118572663   34 ECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTnPTQVNGSVIDEPVRLKHGDVI 88
Cdd:cd22706    35 QQDIQLSGLGIQPEHCIITIENEDVYLTPLEGA-RTCVNGSIVTEKTQLRHGDRI 88
FHA_SNIP1_DDL-like cd22676
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA ...
 25-90 1.88e-04

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438728 [Multi-domain]  Cd Length: 111  Bit Score: 43.44  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663   25 STCLFGRGIE-CDIRIQLPVVSKQHC---------KIEIHEQEAI---LHNFSSTNPTQVNGSVIdEP---VRLKHGDVI 88
Cdd:cd22676    21 SAYLIGRDRRvADIPLDHPSCSKQHAviqfrevekRNEGDVIENIrpyIIDLGSTNGTFLNGEKI-EPrryYELREKDVL 99


                  ..
gi 118572663   89 TI 90
Cdd:cd22676   100 KF 101
FHA_Ct664-like cd22696
forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar ...
 35-95 2.58e-04

forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Chlamydia trachomatis Ct664 protein. Ct664 situates within the type III secretion system cluster that also encodes an STPK (CT673 in C. trachomatis), suggesting a role of CT664 in the chlamydial type III secretion system by mediating phosphorylation-dependent protein-protein interactions. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438748 [Multi-domain]  Cd Length: 97  Bit Score: 42.48  E-value: 2.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 118572663   35 CDIRIQLPVVSKQHCKIEI-HEQEAILHNFSSTNPTQVNGSVIDEPVRLKHGDVITIIDRSF 95
Cdd:cd22696    32 CDIVLQDPSISRQHARLSIdQDNRVFIEDLSSKNGVLVNGKPIEGKEEISGSDVISLGTTSF 93
FHA_KIF14 cd22707
forkhead associated (FHA) domain found in kinesin-like protein KIF14 and similar proteins; ...
 34-99 3.51e-04

forkhead associated (FHA) domain found in kinesin-like protein KIF14 and similar proteins; KIF14 is a microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity. It plays a role in many processes like cell division, cytokinesis and in cell proliferation and apoptosis. KIF14 is a potential oncogene and is involved in the metastasis of various cancers. Mutations of KIF14 cause primary microcephaly by impairing cytokinesis. The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.


Pssm-ID: 438759 [Multi-domain]  Cd Length: 108  Bit Score: 42.64  E-value: 3.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 118572663   34 ECDIRIQLPVVSKQHCKIEiHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHGD-VITIIDRSFRYEN 99
Cdd:cd22707    42 SHDIQLSGALIADDHCTIE-NNGGKVTIIPVGDAETYVNGELISEPTVLHHGDrVILGGDHYFRFNH 107
FHA_GarA_OdhI-like cd22684
forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium ...
 7-90 4.30e-04

forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium glutamicum OdhI and similar proteins; This family includes Mycobacterium tuberculosis glycogen accumulation regulator GarA and Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI). GarA is involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB. GarA binds to Kgd, Gdh, GltB, PknB, and the N-terminal region of PknG via its FHA domain. OdhI is an essential component of the PknG signaling pathway. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438736 [Multi-domain]  Cd Length: 94  Bit Score: 41.98  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    7 LVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEpVRLKHGD 86
Cdd:cd22684     3 LLVVRRGPNAGARFLLDQDVTTAGRHPESDIFLDDVTVSRRHAEFRRAEGGFVVRDVGSLNGTYVNRERIDS-AVLRNGD 81


                  ....
gi 118572663   87 VITI 90
Cdd:cd22684    82 EVQI 85
FHA_EmbR-like cd22669
forkhead associated (FHA) domain found in Mycobacterium tuberculosis transcriptional ...
 6-98 5.06e-04

forkhead associated (FHA) domain found in Mycobacterium tuberculosis transcriptional regulatory protein EmbR and similar proteins; EmbR is a transcriptional regulator of the embCAB operon encoding cell wall arabinosyltransferases (EmbC, -A, and -B), and is phosphorylated by the cognate mycobacterial serine/threonine protein kinase PknH. It interacts with RNA polymerase and possesses a phosphorylation-dependent ATPase activity. EmbR contains a regulatory C-terminal forkhead-associated (FHA) domain, which mediates binding to a threonine-phosphorylated site in PknH. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438721 [Multi-domain]  Cd Length: 89  Bit Score: 41.63  E-value: 5.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663    6 RLVTIkrsgVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHG 85
Cdd:cd22669     1 YLHDI----ASGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSAVTLNDG 76

                          90
                  ....*....|...
gi 118572663   86 DVITIIDRSFRYE 98
Cdd:cd22669    77 DHIRICDHEFTFQ 89
FHA_DUN1-like cd22683
forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein ...
 30-90 8.12e-04

forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein kinase DUN1 and similar proteins; DUN1 is a protein kinase that controls the DNA damage response in yeast. It phosphorylates SML1 on serine residues and cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438735 [Multi-domain]  Cd Length: 96  Bit Score: 40.94  E-value: 8.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 118572663   30 GRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEP-VRLKHGDVITI 90
Cdd:cd22683    26 GRSRSCDLVLSDPSISRFHAELRLEQNGINVIDNNSANGTFINGKRIKGKtYILKNGDIIVF 87
FHA_Rv1747-like_rpt1 cd22694
first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
 16-88 9.52e-04

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438746 [Multi-domain]  Cd Length: 93  Bit Score: 40.77  E-value: 9.52e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118572663   16 DGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEiHEQEA-ILHNFSSTNPTQVNGSVIDEpVRLKHGDVI 88
Cdd:cd22694     7 GGELRFDPGSSVRIGRDPDADVRLDDPRVSRRHALLE-FDGDGwVYTDLGSRNGTYLNGRRVQQ-VKLSDGTRV 78
FHA_AGGF1 cd22686
forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 ...
 30-90 1.55e-03

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438738 [Multi-domain]  Cd Length: 123  Bit Score: 41.11  E-value: 1.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 118572663   30 GRGIECDIRIQLP--VVSKQHCKIEIHEQEAILH--NFSSTNPTQVNGSVI------DEPVRLKHGDVITI 90
Cdd:cd22686    31 GREKDHGHTIRIPelGVSKFHAEIYYDDDEQSYTivDLGSQNGTYLNGVRIsqpkekSDPYPLTHGDELKI 101
FHA_APTX-like cd22671
forkhead associated (FHA) domain found in aprataxin, bifunctional polynucleotide phosphatase ...
 14-98 1.75e-03

forkhead associated (FHA) domain found in aprataxin, bifunctional polynucleotide phosphatase/kinase (PNKP), aprataxin and PNK-like factor (APLF), and similar proteins; The family includes aprataxin, PNKP, and APLF. Aprataxin (EC 3.6.1.71/EC 3.6.1.72), also called forkhead-associated domain histidine triad-like protein (FHA-HIT), is a DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair, and base excision repair. It catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. It can also hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, it catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA but has higher specific activity with 5'-linked adenosine (AppDNA). PNKP (EC 3.1.3.32/EC 2.7.1.78), also called DNA 5'-kinase/3'-phosphatase, or polynucleotide kinase-3'-phosphatase, plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNKP ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. APLF, also called apurinic-apyrimidinic endonuclease APLF, PNK and APTX-like FHA domain-containing protein, or XRCC1-interacting protein 1 (XIP1), is a novel apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease with conserved zinc-finger-like motifs involved in single-strand and double-strand DNA break repair. It is recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. It can introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, APLF promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Members of this family contain an FHA domain at their N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438723 [Multi-domain]  Cd Length: 101  Bit Score: 40.37  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663   14 GVDGPHFPLSL--STCLfGRGIECDIRIQLpvVSKQHCKIEIHEQEAILH-NFSSTNPTQVN-----GSVI--DEPVRLK 83
Cdd:cd22671     7 GGGGPPIELKEggPTVL-GRGPLLGIRDKR--VSRKQAEITVDDDTGSVTvTQLGTNPSFVNradgeGKVLkkGESVELK 83

                          90
                  ....*....|....*
gi 118572663   84 HGDVITIIDRSFRYE 98
Cdd:cd22671    84 DGDVISLLPGKYPFR 98
FHA_Par42-like cd22675
forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar ...
 12-88 1.82e-03

forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar proteins; TbPar42 is a nuclear protein that plays a key role in parasite cell proliferation. It exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Its PPIase domain adopts a parvulin fold and reflects structural elements of Pin1-type proteins but is catalytically inactive. Its FHA domain may be involved in the binding of phosphorylated target proteins. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438727 [Multi-domain]  Cd Length: 113  Bit Score: 40.62  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118572663   12 RSGVDGPHFPLS-LSTCLFGRGIECDIRIQLPVVSKQHCKIEIH--EQEAILHNFSSTNPTQVNGSVIDE--PVRLKHGD 86
Cdd:cd22675    15 RDGVPLPPLGLDrFPFYLFGRSPVCDYVLEHPSISSVHAVLVFHgeQKCFVLMDLGSTNGVKLNGKRIEKgrPLPLPVGS 94


                  ..
gi 118572663   87 VI 88
Cdd:cd22675    95 VI 96
FHA_NBN cd22667
forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also ...
 29-89 2.96e-03

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438719 [Multi-domain]  Cd Length: 108  Bit Score: 40.00  E-value: 2.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 118572663   29 FGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNP----------TQVNGSVI--DEPVRLKHGDVIT 89
Cdd:cd22667    24 VGRKDCDIIIVDDSSISRKHATLTVLHPEANLSDPDTRPEltlkdlskygTFVNGEKLkgGSEVTLKDGDVIT 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH