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Conserved domains on  [gi|1183153492|gb|ARJ54492|]
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growth hormone 1, partial [Upupa epops]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
growth_hormone_like super family cl07831
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
 1-84 1.72e-48

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


The actual alignment was detected with superfamily member cd10285:

Pssm-ID: 324147  Cd Length: 180  Bit Score: 151.45  E-value: 1.72e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183153492   1 LAAETYKEFERTYIPEDQRHANKNSQVAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLSPVQYLSKVFTNNLVF 80
Cdd:cd10285    15 LAADIYKDFERSYIPEEQRQSNKNSPAAFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLKPVQFLSSVFTNQLHF 94


                  ....
gi 1183153492  81 GTSD 84
Cdd:cd10285    95 GSSD 98
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
 1-84 1.72e-48

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 151.45  E-value: 1.72e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183153492   1 LAAETYKEFERTYIPEDQRHANKNSQVAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLSPVQYLSKVFTNNLVF 80
Cdd:cd10285    15 LAADIYKDFERSYIPEEQRQSNKNSPAAFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLKPVQFLSSVFTNQLHF 94


                  ....
gi 1183153492  81 GTSD 84
Cdd:cd10285    95 GSSD 98
Hormone_1 pfam00103
Somatotropin hormone family;
1-84 1.87e-16

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 70.10  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183153492   1 LAAETYKEFERTYIPEDQRHANKNSqvaFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLSPVQYL----SKVFTN 76
Cdd:pfam00103  46 LASDMFTEFDENYAQGKGYFIRRTT---SCHTNSIHTPENREKAQQTSNEELLKWSLMLLYSWLEPLYHLvtelSSMKEV 122


                  ....*...
gi 1183153492  77 NLVFGTSD 84
Cdd:pfam00103 123 SDTILSKA 130
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
 1-84 1.72e-48

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 151.45  E-value: 1.72e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183153492   1 LAAETYKEFERTYIPEDQRHANKNSQVAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLSPVQYLSKVFTNNLVF 80
Cdd:cd10285    15 LAADIYKDFERSYIPEEQRQSNKNSPAAFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLKPVQFLSSVFTNQLHF 94


                  ....
gi 1183153492  81 GTSD 84
Cdd:cd10285    95 GSSD 98
growth_hormone_like cd10284
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
 1-76 3.68e-21

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


Pssm-ID: 198434  Cd Length: 178  Bit Score: 81.77  E-value: 3.68e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1183153492   1 LAAETYKEFERTYIPEDQRhanKNSQVAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLSPVQYLSKVFTN 76
Cdd:cd10284    15 LSSEAYAEFEEKYIPGENP---PNNVVMSCHTASIPTPSSKEEAQQKSDKELLRISLELLQSWSEPLLHLHTVLAN 87
Hormone_1 pfam00103
Somatotropin hormone family;
1-84 1.87e-16

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 70.10  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183153492   1 LAAETYKEFERTYIPEDQRHANKNSqvaFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLSPVQYL----SKVFTN 76
Cdd:pfam00103  46 LASDMFTEFDENYAQGKGYFIRRTT---SCHTNSIHTPENREKAQQTSNEELLKWSLMLLYSWLEPLYHLvtelSSMKEV 122


                  ....*...
gi 1183153492  77 NLVFGTSD 84
Cdd:pfam00103 123 SDTILSKA 130
somatolactin cd10286
Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to ...
 1-70 5.48e-09

Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to Actinopterygii is expressed in the pars intermedia bordering the neurohypophysis (posterior pituitary). Somatolactin appears to be involved in acid-base regulation, but much of its physiological role remains to be understood.


Pssm-ID: 198436  Cd Length: 207  Bit Score: 50.24  E-value: 5.48e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183153492   1 LAAETYKEFERTYIPEDQRhANKNSQVAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLSPVQYL 70
Cdd:cd10286    37 VSEESCTLFEEMFIPFSVR-ALLIQEGNACSTKTVSIPTSKTEIQQISDKWLLHSVLILVQFWIDPLVDL 105
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
 1-70 9.61e-06

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 41.48  E-value: 9.61e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183153492   1 LAAETYKEFERTYiPEDQRHANKNSQVafCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLSPVQYL 70
Cdd:cd10288    32 LSSEMFNEFDENY-AQGRGFVDRALTS--CHTSSLTTPENKEQAQQIKNEDLLKLIISLLRSWNEPLKHL 98
prolactin_2 cd10287
Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the ...
 1-70 2.43e-04

Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the growth-hormone-like helical cytokines, which is found in vertebrata (except for mammals). The protein has been shown to be expressed in the zebrafish eye and brain, but not the pituitary gland, and might play a role in retina development.


Pssm-ID: 198437  Cd Length: 184  Bit Score: 37.55  E-value: 2.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1183153492   1 LAAETYKEFERTYIPE-DQRHANKnsqvafCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLSPVQYL 70
Cdd:cd10287    18 LSSELHWELEQYFLPSrNIRRKRK------CHTAGILTPNGKENAQKLEREELTEVILRLLGAWREPLSHF 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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