NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|118197478|gb|ABK78702|]
View 

ubiquitin protein ligase E3A, partial [Notamacropus eugenii]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HECTc super family cl27008
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 1-51 6.84e-19

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


The actual alignment was detected with superfamily member cd00078:

Pssm-ID: 474882 [Multi-domain]  Cd Length: 352  Bit Score: 76.83  E-value: 6.84e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 118197478   1 EFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKyLFRPEEIELLICGS 51
Cdd:cd00078  190 EYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLS-LFTPEELELLICGS 239
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 1-51 6.84e-19

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 76.83  E-value: 6.84e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 118197478   1 EFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKyLFRPEEIELLICGS 51
Cdd:cd00078  190 EYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLS-LFTPEELELLICGS 239
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 1-52 6.54e-18

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 73.80  E-value: 6.54e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 118197478    1 EFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKyLFRPEEIELLICGSR 52
Cdd:pfam00632 140 EYIRLYVDYRLNKSIEPQLEAFRKGFYSVIPKEALS-LFTPEELELLICGSP 190
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 1-52 8.40e-18

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 73.81  E-value: 8.40e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 118197478     1 EFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKyLFRPEEIELLICGSR 52
Cdd:smart00119 167 EYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLK-LFDPEELELLICGSP 217
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
1-52 4.28e-11

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 55.16  E-value: 4.28e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 118197478   1 EFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKYlFRPEEIELLICGSR 52
Cdd:COG5021  703 EYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQI-FDESELELLIGGIP 753
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 1-51 6.84e-19

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 76.83  E-value: 6.84e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 118197478   1 EFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKyLFRPEEIELLICGS 51
Cdd:cd00078  190 EYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLS-LFTPEELELLICGS 239
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 1-52 6.54e-18

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 73.80  E-value: 6.54e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 118197478    1 EFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKyLFRPEEIELLICGSR 52
Cdd:pfam00632 140 EYIRLYVDYRLNKSIEPQLEAFRKGFYSVIPKEALS-LFTPEELELLICGSP 190
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 1-52 8.40e-18

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 73.81  E-value: 8.40e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 118197478     1 EFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKyLFRPEEIELLICGSR 52
Cdd:smart00119 167 EYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLK-LFDPEELELLICGSP 217
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
1-52 4.28e-11

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 55.16  E-value: 4.28e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 118197478   1 EFVSLYADYILNKSVEKQFKAFRRGFHMVTNESPLKYlFRPEEIELLICGSR 52
Cdd:COG5021  703 EYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQI-FDESELELLIGGIP 753
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH