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Conserved domains on  [gi|1176173640|gb|OQX88948|]
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hypothetical protein B6D60_00625 [candidate division KSB1 bacterium 4484_87]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
6-171 2.12e-23

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 91.11  E-value: 2.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640   6 DKAAKKSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEHGFLSLMELWETNIAkRIFRITDPEEK 85
Cdd:COG1309     3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALE-EALAAEDPRER 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  86 LKAIFYSFLDFFEgDHSEIIDVMLDFWAEAIRQKDEqrlrvinLEKIYQDFREIIIAVLKEGiriGRFKPMNTFMVASLL 165
Cdd:COG1309    82 LRALLRAYLEFLA-ENPALARLLLAEAAELPELRAA-------LRALLRRLRALLAELLRAG---GLLADVDPDALARAL 150


                  ....*.
gi 1176173640 166 IGMTDG 171
Cdd:COG1309   151 LALLDG 156
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
6-171 2.12e-23

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 91.11  E-value: 2.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640   6 DKAAKKSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEHGFLSLMELWETNIAkRIFRITDPEEK 85
Cdd:COG1309     3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALE-EALAAEDPRER 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  86 LKAIFYSFLDFFEgDHSEIIDVMLDFWAEAIRQKDEqrlrvinLEKIYQDFREIIIAVLKEGiriGRFKPMNTFMVASLL 165
Cdd:COG1309    82 LRALLRAYLEFLA-ENPALARLLLAEAAELPELRAA-------LRALLRRLRALLAELLRAG---GLLADVDPDALARAL 150


                  ....*.
gi 1176173640 166 IGMTDG 171
Cdd:COG1309   151 LALLDG 156
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 1-197 2.16e-15

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 71.03  E-value: 2.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640   1 MPKVVDKAAKKSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEHGFLSLM-ELWETNIAKRIFRI 79
Cdd:PRK00767    1 MPKVGMEPIRRQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLrQLGDAVLARLAAAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  80 TDPEEKLKAIFY-SFLDF-FEgdhSEIIDVMLDFWAEAIRQKDEQRLRVINLEKIYQ----DFREIiiaVLKEGIRIgrf 153
Cdd:PRK00767   81 DTPRARLRAIVEaNFDASqFS---SPAMKTWLAFWASSMHSPDLRRLQRINSRRLYSnllfEFRRL---LPREQARE--- 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1176173640 154 kpmntfmVASLLIGMTDGLMLQWIMNKDLIDIKEAyRCLIEEVL 197
Cdd:PRK00767  152 -------AAEGLAALIDGLWLRGALSGDPEDAEAA-RALAYDYI 187
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
14-58 3.22e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 61.27  E-value: 3.22e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1176173640  14 IVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFE 58
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
14-69 4.31e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 48.36  E-value: 4.31e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  14 IVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKND----IFEHGFLSLMELWE 69
Cdd:NF041196   11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAlaraVLEEQVARLREAVE 70
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 11-96 4.57e-07

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 48.29  E-value: 4.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  11 KSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEH-------GFLSLMElwetnIAKRIFRITDPE 83
Cdd:NF037937    1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEYlvtsffeGYLEILE-----EGFEELKNLSAK 75

                          90
                  ....*....|...
gi 1176173640  84 EKLKAIFYSFLDF 96
Cdd:NF037937   76 ECLKQLVRNILHY 88
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
6-171 2.12e-23

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 91.11  E-value: 2.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640   6 DKAAKKSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEHGFLSLMELWETNIAkRIFRITDPEEK 85
Cdd:COG1309     3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALE-EALAAEDPRER 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  86 LKAIFYSFLDFFEgDHSEIIDVMLDFWAEAIRQKDEqrlrvinLEKIYQDFREIIIAVLKEGiriGRFKPMNTFMVASLL 165
Cdd:COG1309    82 LRALLRAYLEFLA-ENPALARLLLAEAAELPELRAA-------LRALLRRLRALLAELLRAG---GLLADVDPDALARAL 150


                  ....*.
gi 1176173640 166 IGMTDG 171
Cdd:COG1309   151 LALLDG 156
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 1-197 2.16e-15

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 71.03  E-value: 2.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640   1 MPKVVDKAAKKSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEHGFLSLM-ELWETNIAKRIFRI 79
Cdd:PRK00767    1 MPKVGMEPIRRQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLrQLGDAVLARLAAAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  80 TDPEEKLKAIFY-SFLDF-FEgdhSEIIDVMLDFWAEAIRQKDEQRLRVINLEKIYQ----DFREIiiaVLKEGIRIgrf 153
Cdd:PRK00767   81 DTPRARLRAIVEaNFDASqFS---SPAMKTWLAFWASSMHSPDLRRLQRINSRRLYSnllfEFRRL---LPREQARE--- 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1176173640 154 kpmntfmVASLLIGMTDGLMLQWIMNKDLIDIKEAyRCLIEEVL 197
Cdd:PRK00767  152 -------AAEGLAALIDGLWLRGALSGDPEDAEAA-RALAYDYI 187
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
14-58 3.22e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 61.27  E-value: 3.22e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1176173640  14 IVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFE 58
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
TetR_C_6 pfam13977
BetI-type transcriptional repressor, C-terminal; This family comprises the C-terminal portion ...
 83-190 4.13e-13

BetI-type transcriptional repressor, C-terminal; This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.


Pssm-ID: 433619  Cd Length: 112  Bit Score: 63.09  E-value: 4.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  83 EEKLKAIFYSFLDFFEGDHSEIiDVMLDFWAEAIRQKDEQRLRVINlekiYQDFREIIIAVLKEGIRIGRFKPMNTFMVA 162
Cdd:pfam13977   1 RERLRAILEALLPLDQERRAEA-RVWLAFWAEALRDPELAELQREL----YRRLRSNLAALLRRLAEGGLFADADAEAEA 75

                          90       100
                  ....*....|....*....|....*...
gi 1176173640 163 SLLIGMTDGLMLQWIMNKDLIDIKEAYR 190
Cdd:pfam13977  76 ERLAALIDGLWLRALLSPDRLDPERARA 103
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
2-200 5.10e-13

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 64.57  E-value: 5.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640   2 PKVVDKAAKKSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEHGFLSLMELWETNIAKRIFRITD 81
Cdd:COG3226     1 PRRRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  82 PEEKLKAIFYSFLDFFEGDHSEIIdVMLDFWAEAIRQKdeqRLRVInLEKIYQDFREIIIAVLKegiRIGRFKPMNTfmv 161
Cdd:COG3226    81 LEDAAEALADLLAELLPADRDRLL-ARYELYLEALRDP---ELRAL-LRRWRDRLREALARLLA---ALGSPDPPET--- 149

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1176173640 162 ASLLIGMTDGLMLQWIMNKDLIDiKEAYRCLIEEVLSGI 200
Cdd:COG3226   150 ARALVALIDGLTLHALLDPDPLT-REELRAALRRLLRAL 187
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 11-197 1.64e-11

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 60.91  E-value: 1.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  11 KSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEHGFL---SLMELWETNIAKRIFRitDPEEKLK 87
Cdd:PRK09975   13 RQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLqqpPLRELIQEHLTAGLEH--DPLQQLR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  88 AIFYsfldffegdhseiidVMLDFWAEAIRQK-----------------DEQRLRvinlEKI---YQDFREiiiaVLKEG 147
Cdd:PRK09975   91 EKFI---------------AGLQYIAKIPRQQallqilyhkcefndemlSEGVIR----EKMgfnPQTLRE----VLQRC 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1176173640 148 IRIGRFKP-MNTFMVASLLIGMTDGLMLQWIMNKDLIDIKEAYRCLIEEVL 197
Cdd:PRK09975  148 QQQGCIANnLDLDVVLIILHGAFSGIVKNWLMNPAGYDLYKQAPALVDNVL 198
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 11-197 7.50e-10

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 56.17  E-value: 7.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  11 KSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEhgflslmELWETNIAKrifrITDPEEKLKAIf 90
Cdd:PRK10668   13 RQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFS-------EIWELSESK----IGELELEYQAK- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  91 ysfldfFEGDHSEIIDVMLDFWAEAIRqkDEQRLRVInLEKIY------------QDFREI--------IIAVLKEGIRI 150
Cdd:PRK10668   81 ------FPDDPLSVLREILIYILEATV--TDERRRLL-MEIIFhkcefvgemavvQQAQRNlclesydrIEQTLKHCIEA 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1176173640 151 GRFkPMN--TFMVASLLIGMTDGLMLQWIMNKDLIDIKEAYRCLIEEVL 197
Cdd:PRK10668  152 KQL-PANlmTRRAAIIMRGYISGLMENWLFAPESFDLKKEARDLVDILL 199
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
14-69 4.31e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 48.36  E-value: 4.31e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  14 IVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKND----IFEHGFLSLMELWE 69
Cdd:NF041196   11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAlaraVLEEQVARLREAVE 70
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 11-96 4.57e-07

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 48.29  E-value: 4.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  11 KSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEH-------GFLSLMElwetnIAKRIFRITDPE 83
Cdd:NF037937    1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEYlvtsffeGYLEILE-----EGFEELKNLSAK 75

                          90
                  ....*....|...
gi 1176173640  84 EKLKAIFYSFLDF 96
Cdd:NF037937   76 ECLKQLVRNILHY 88
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 81-177 2.15e-05

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 42.16  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  81 DPEEKLKAIFYSFLDFFEGDHSEIIdVmldFWAEAIRQKDEQRLRVINLEKiyqDFREIIIAVLKEGIRIGRFKPMNTFM 160
Cdd:pfam17932   3 SPVERLRALVRAHVRVHAERRDEAA-V---FLRELRSLSPEHRAEIRALRR---EYERLLRDLIEEGVAAGEFRDLDPKL 75

                          90
                  ....*....|....*..
gi 1176173640 161 VASLLIGmtdglMLQWI 177
Cdd:pfam17932  76 AALAILG-----MLNWV 87
TetR_C_17 pfam17922
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 107-174 1.24e-03

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain present in Yfir transcription regulator proteins found in Bacillus subtilus. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.


Pssm-ID: 436144  Cd Length: 100  Bit Score: 36.88  E-value: 1.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173640 107 VMLDFWAEAIRQKDEQRLrvinLEKIYQDFREIIIAVLKEGIRIGRFKP-MNTFMVASLLIGMTDGLML 174
Cdd:pfam17922  23 VAYEYFVTSWREKERRAY----LQNRYERAVKVFKAFLQKGVDRGEFKPvLPLESIARFFISFIDGLIL 87
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 8-68 1.38e-03

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 38.37  E-value: 1.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176173640   8 AAKKSEIVNAAMKVFAQKGFANTKMSDIARAAKIGKGTIYEYFHNKNDIFEHGFLSLMELW 68
Cdd:PRK15008   17 SAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIW 77
TetR_C_4 pfam08359
YsiA-like protein, C-terminal region; The members of this family are thought to be TetR-type ...
 72-193 1.63e-03

YsiA-like protein, C-terminal region; The members of this family are thought to be TetR-type transcriptional regulators that bear particular similarity to YsiA, a hypothetical protein expressed by B. subtilis.


Pssm-ID: 285548  Cd Length: 133  Bit Score: 37.35  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173640  72 IAKRIFRITDPEEKLKAIFYSFLDFFEGDHSEIIDVMLDfwaeaIRQKDEQ-RLRVINLEKIYQDFREIIIAvlkEGIRI 150
Cdd:pfam08359  12 IREAIAGKVSAEEKLRLLIEMHFSQLSADPHLAIVTQLE-----LRQSNLElRQKINEVLKGYLTLIDEIIA---EGKES 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1176173640 151 GRFKP-MNTFMVASLLIGMTDGLMLQWIMNKDLIDI----KEAYRCLI 193
Cdd:pfam08359  84 GEFREeLDVRLARQMIFGTLDETVTNWVMNDQKYDLvalaEPVHELLI 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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