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Conserved domains on  [gi|1176173632|gb|OQX88940|]
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hypothetical protein B6D60_00585 [candidate division KSB1 bacterium 4484_87]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 11432856)

lytic transglycosylase domain-containing protein similar to lytic transglycosylase which catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 93-234 6.07e-42

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 142.83  E-value: 6.07e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  93 EIHKMCQKYtNLNVDLICATITHESAlsWDPQVVSPVGAIGLMQIMPETGANLAKDEGINWTSAEdvLFDPIINIRLGCR 172
Cdd:COG0741   106 LIEEAAKKY-GVDPALVLALIRQESA--FNPNAVSPAGARGLMQLMPATARRLGLKLGLGPSPDD--LFDPETNIRAGAA 180

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176173632 173 YLSQLIQEYE--LDGGLAAYNGGEKRAKLWLEKRNNKSDFTLLWEETQFYVPSILKLYAQFQNQ 234
Cdd:COG0741   181 YLRELLDRFDgdLVLALAAYNAGPGRVRRWLRRNGDRDGEIIPYAETRNYVKKVLANYAIYRAG 244
 
Name Accession Description Interval E-value
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 93-234 6.07e-42

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 142.83  E-value: 6.07e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  93 EIHKMCQKYtNLNVDLICATITHESAlsWDPQVVSPVGAIGLMQIMPETGANLAKDEGINWTSAEdvLFDPIINIRLGCR 172
Cdd:COG0741   106 LIEEAAKKY-GVDPALVLALIRQESA--FNPNAVSPAGARGLMQLMPATARRLGLKLGLGPSPDD--LFDPETNIRAGAA 180

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176173632 173 YLSQLIQEYE--LDGGLAAYNGGEKRAKLWLEKRNNKSDFTLLWEETQFYVPSILKLYAQFQNQ 234
Cdd:COG0741   181 YLRELLDRFDgdLVLALAAYNAGPGRVRRWLRRNGDRDGEIIPYAETRNYVKKVLANYAIYRAG 244
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 86-228 3.84e-38

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 129.94  E-value: 3.84e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  86 LKYniAREIHKMCQKYtnlNVD--LICATITHESalSWDPQVVSPVGAIGLMQIMPETGANLAKDEGINWTSAEDvLFDP 163
Cdd:cd16896     2 LKY--REYIEKYAKEY---GVDplLVAAVIKVES--NFNPNAVSSKGAIGLMQIMPETAEWIAEKLGLEDFSEDD-LYDP 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176173632 164 IINIRLGCRYLSQLIQEY--ELDGGLAAYNGGEKRAKLWLEKRNNKSDFTLLWE----ETQFYVPSILKLY 228
Cdd:cd16896    74 ETNIRLGTWYLSYLLKEFdgNLVLALAAYNAGPGNVDKWLKDGGWSGDGKTLDQipfpETRHYVKKVLKNY 144
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 99-212 1.24e-21

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 86.21  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  99 QKYtNLNVDLICATITHESalSWDPQVVSPVGAIGLMQIMPETGANLAKDEGINwtsaEDVLFDPIINIRLGCRYLSQLI 178
Cdd:pfam01464   6 QKY-GVDPSLLLAIAQQES--GFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPG----VDDLFDPEKNIKAGTKYLKELY 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176173632 179 QEYELDGGLA--AYNGGEKRAKLWLEKRNNKSDFTL 212
Cdd:pfam01464  79 KQYGGDLWLAlaAYNAGPGRVRKWIKNAGAKDKKLL 114
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 116-235 6.47e-20

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 88.19  E-value: 6.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632 116 ESAlsWDPQVVSPVGAIGLMQIMPETGANLAKDEGINWTSAEDVLFDPIINIRLGCRYLSQLIQEYELDGGL--AAYNGG 193
Cdd:PRK11619  504 ESA--WNPKARSPVGASGLMQIMPGTATHTVKMFSIPGYSSSSQLLDPETNINIGTSYLEYVYQQFGNNRILasAAYNAG 581

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1176173632 194 EKRAKLWLEKRNNKSD---F--TLLWEETQFYVPSILK---LYAQFQNQK 235
Cdd:PRK11619  582 PGRVRTWLGNSAGRIDavaFveSIPFSETRGYVKNVLAydaYYRYFMGQK 631
 
Name Accession Description Interval E-value
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 93-234 6.07e-42

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 142.83  E-value: 6.07e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  93 EIHKMCQKYtNLNVDLICATITHESAlsWDPQVVSPVGAIGLMQIMPETGANLAKDEGINWTSAEdvLFDPIINIRLGCR 172
Cdd:COG0741   106 LIEEAAKKY-GVDPALVLALIRQESA--FNPNAVSPAGARGLMQLMPATARRLGLKLGLGPSPDD--LFDPETNIRAGAA 180

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176173632 173 YLSQLIQEYE--LDGGLAAYNGGEKRAKLWLEKRNNKSDFTLLWEETQFYVPSILKLYAQFQNQ 234
Cdd:COG0741   181 YLRELLDRFDgdLVLALAAYNAGPGRVRRWLRRNGDRDGEIIPYAETRNYVKKVLANYAIYRAG 244
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 86-228 3.84e-38

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 129.94  E-value: 3.84e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  86 LKYniAREIHKMCQKYtnlNVD--LICATITHESalSWDPQVVSPVGAIGLMQIMPETGANLAKDEGINWTSAEDvLFDP 163
Cdd:cd16896     2 LKY--REYIEKYAKEY---GVDplLVAAVIKVES--NFNPNAVSSKGAIGLMQIMPETAEWIAEKLGLEDFSEDD-LYDP 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176173632 164 IINIRLGCRYLSQLIQEY--ELDGGLAAYNGGEKRAKLWLEKRNNKSDFTLLWE----ETQFYVPSILKLY 228
Cdd:cd16896    74 ETNIRLGTWYLSYLLKEFdgNLVLALAAYNAGPGNVDKWLKDGGWSGDGKTLDQipfpETRHYVKKVLKNY 144
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 93-225 9.05e-37

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 126.44  E-value: 9.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  93 EIHKMCQKYtNLNVDLICATITHESAlsWDPQVVSPVGAIGLMQIMPETGANLAKDEGINWTSAEDvLFDPIINIRLGCR 172
Cdd:cd13401     9 LVERAAKKN-GLDPALVYAIIRQESA--FDPDAVSPAGALGLMQLMPATAKDVAKKLGLPYYSPRD-LFDPEYNIRLGSA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176173632 173 YLSQLIQEYelDG----GLAAYNGGEKRAKLWLEKRNNKSDFtlLW------EETQFYVPSIL 225
Cdd:cd13401    85 YLAELLDRF--DGnpvlALAAYNAGPGRVRRWLKRRGDLDPD--LWietipfSETRNYVKRVL 143
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 107-229 1.25e-33

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 117.31  E-value: 1.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632 107 DLICATITHESalSWDPQVVSPVGAIGLMQIMPETGANLAKDEGINwtsaedvLFDPIINIRLGCRYLSQLIQEYE--LD 184
Cdd:cd00254     2 ALVLAVIRVES--GFNPRAVSPAGARGLMQLMPGTARDLGRRGVDD-------LFDPEENIRAGARYLRELLDRFGgdLE 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1176173632 185 GGLAAYNGGEKRAKLWLEKRNnksdftLLWEETQFYVPSILKLYA 229
Cdd:cd00254    73 LALAAYNAGPGAVDRWGGGEV------PPYKETRNYVQRVLAYYQ 111
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 99-212 1.24e-21

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 86.21  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  99 QKYtNLNVDLICATITHESalSWDPQVVSPVGAIGLMQIMPETGANLAKDEGINwtsaEDVLFDPIINIRLGCRYLSQLI 178
Cdd:pfam01464   6 QKY-GVDPSLLLAIAQQES--GFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPG----VDDLFDPEKNIKAGTKYLKELY 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176173632 179 QEYELDGGLA--AYNGGEKRAKLWLEKRNNKSDFTL 212
Cdd:pfam01464  79 KQYGGDLWLAlaAYNAGPGRVRKWIKNAGAKDKKLL 114
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 99-233 2.73e-21

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 91.28  E-value: 2.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  99 QKY---TNLNVDLICATITHESAlsWDPQVVSPVGAIGLMQIMPETGANLAKDEginwtsaedvLFDPIINIRLGCRYLS 175
Cdd:COG4623   269 EKYaeeYGLDWRLLAALAYQESH--WNPRARSPTGARGLMQLMPATAKELGVDD----------RLDPEQSIRAGAKYLR 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632 176 QLIQEYELDGG--------LAAYNGGE-------KRAK-------LWLEKRNNKSDFTLLW----EETQFYVPSILKLYA 229
Cdd:COG4623   337 WLYDRFPEAIDepdrwwfaLAAYNAGPghvqdarRLAKkqgldpdRWFDVEKSQPKYYDTGyargRETVNYVPNIRAYYD 416


                  ....
gi 1176173632 230 QFQN 233
Cdd:COG4623   417 IYKR 420
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 116-235 6.47e-20

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 88.19  E-value: 6.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632 116 ESAlsWDPQVVSPVGAIGLMQIMPETGANLAKDEGINWTSAEDVLFDPIINIRLGCRYLSQLIQEYELDGGL--AAYNGG 193
Cdd:PRK11619  504 ESA--WNPKARSPVGASGLMQIMPGTATHTVKMFSIPGYSSSSQLLDPETNINIGTSYLEYVYQQFGNNRILasAAYNAG 581

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1176173632 194 EKRAKLWLEKRNNKSD---F--TLLWEETQFYVPSILK---LYAQFQNQK 235
Cdd:PRK11619  582 PGRVRTWLGNSAGRIDavaFveSIPFSETRGYVKNVLAydaYYRYFMGQK 631
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 96-193 8.08e-19

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 80.27  E-value: 8.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  96 KMCQKYtnlNVD--LICATITHESalSWDPQVVSPVGAIGLMQIMPETganlAKDEGINwtsaedVLFDPIINIRLGCRY 173
Cdd:cd13403     3 KYAEKY---GFDwrLLAAQAYQES--RFNPNARSPAGARGLMQLMPST----ARELGVN------DRLDPEQNIHAGAKY 67

                          90       100
                  ....*....|....*....|....*...
gi 1176173632 174 LSQLIQEY--ELDGG------LAAYNGG 193
Cdd:cd13403    68 LRYLRDRFppDIDEPdrlkfaLAAYNAG 95
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 99-193 3.00e-15

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 70.67  E-value: 3.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  99 QKYtNLNVDLICATITHESalSWDPQVVSPVGAIGLMQIMPETGanlAKD-----EGINWTSAEDVLFDPIINIRLGCRY 173
Cdd:cd16893     8 KKY-GVDPALILAIIETES--SFNPYAVSHSPAYGLMQIVPSTA---GRDvyrllGGKGGLPSKSYLFDPENNIDIGTAY 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1176173632 174 LSQL------------IQEYELdggLAAYNGG 193
Cdd:cd16893    82 LHILqnrylkgiknpkSREYCA---IAAYNGG 110
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 116-225 6.85e-15

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 68.70  E-value: 6.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632 116 ESALswDPQVVSPVGAIGLMQIMPETGANLakdeGINWTSAEDVLFDPIINIRLGCRYLSQLiqeYELDGG----LAAYN 191
Cdd:cd16894    17 ESGF--NPDAVSSAGAAGLWQFMPATAREY----GLRVDSWVDERRDPEKSTRAAARYLKDL---YKRFGDwllaLAAYN 87

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1176173632 192 GGEKRAKlWLEKRNNKSDFTLLW-----EETQFYVPSIL 225
Cdd:cd16894    88 AGEGRVR-RAIKRAGTDKWEDYYrlylpAETRRYVPKFL 125
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
94-193 3.30e-10

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 58.91  E-value: 3.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  94 IHKMCQKYtNLNVDLICATITHESalSWDPQVVSPVGAIGLMQIMPET-GANLAKDEGINWTSAEDVLFDPIINIRLGCR 172
Cdd:PRK11671  196 VRKASRKY-GVDESLILAIMQTES--SFNPYAVSRSDALGLMQVVQHTaGKDVFRMKGKSGQPSRSYLFDPANNIDTGTA 272

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1176173632 173 YLSQLIQEYeLDG----------GLAAYNGG 193
Cdd:PRK11671  273 YLAILQNVY-LGGitnptsrryaVITAYNGG 302
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 103-194 1.48e-08

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 51.16  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632 103 NLNVDLICATITHESalSWDPQ-VVSPVGAIGLMQIMPETGANLA----KDEGINWTSAEDVLFdpiiniRLGcRYLSQL 177
Cdd:cd13399     2 GVPPGILAAILGVES--GFGPNaGGSPAGAQGIAQFMPSTWKAYGvdgnGDGKADPFNPEDAIA------SAA-NYLCRH 72

                          90       100
                  ....*....|....*....|...
gi 1176173632 178 IQE------YELDGGLAAYNGGE 194
Cdd:cd13399    73 GWDlnaflgEDNFLALAAYNAGP 95
PHA00658 PHA00658
putative lysin
 125-233 1.95e-07

putative lysin


Pssm-ID: 106967 [Multi-domain]  Cd Length: 720  Bit Score: 51.36  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632 125 VVSPVGAIGLMQIMPETGANLAKDEGINWTSAEdVLFDPIINIRLGCRYLSQLIQEY--ELDGGLAAYNGGEKRAKLWLE 202
Cdd:PHA00658  324 LTSPKGAVGIAQVMPDTAPEAAKLAGLPWDENR-YRNDAAYNRALGMAYFQKQLRDFggDLPKAYAAYNAGPGALQSALK 402

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1176173632 203 KRNNKSDFTLLWEETQFYV----------------PSILKLYAQFQN 233
Cdd:PHA00658  403 DAKDGNWLALLPKETQDYVvknmqaynagqgrparPTLADIEAQLQN 449
PHA00368 PHA00368
internal virion protein D
 120-225 1.19e-05

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 45.93  E-value: 1.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632  120 SWDPQVVSPVGAIGLMQIMPETGANLAKdeginwTSAEDVLFDPIINIRLGCRYLSQLIQEY---ELDGGLaAYNGGEKR 196
Cdd:PHA00368    38 RFNPTAKSPTGPKGLMQFTKATAKALGL------IVDDDDRLDPELAIDAGARYLADLVGKYdgdELKAAL-AYNQGEGR 110

                           90       100
                   ....*....|....*....|....*....
gi 1176173632  197 AKLWLEKRNNKSDFTLLWEETQFYVPSIL 225
Cdd:PHA00368   111 LGAPQLEAYDKGDFASISEEGRNYLRNLL 139
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 103-193 1.47e-05

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 42.90  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632 103 NLNVDLICATITHESalSWDPQVVSP--VG--AIGLMQI----MPEtganLAKdEGInwtSAEDVLFDPIINIRLGCRYL 174
Cdd:cd13400     2 GVPPRLLRAIAKVES--GFNPNAINRnkNGsyDIGLMQInsiwLPE----LAR-YGI---TREELLNDPCTNIYVGAWIL 71

                          90       100
                  ....*....|....*....|...
gi 1176173632 175 SQLIQEYeldG----GLAAYNGG 193
Cdd:cd13400    72 ARNIKRY---GntwkAVGAYNSG 91
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
108-193 1.67e-04

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 42.17  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173632 108 LICATITHESalSWDPQVVSPVGAIGLMQIMPETganlAKDEGINwtsaeDVLfDPIINIRLGCRYLSQL-------IQE 180
Cdd:PRK10859  305 LLAAIAYQES--HWNPQATSPTGVRGLMMLTRNT----AQSMGVT-----DRL-DPEQSIRGGARYLQDLmerlpesIPE 372

                          90
                  ....*....|....
gi 1176173632 181 YE-LDGGLAAYNGG 193
Cdd:PRK10859  373 PErIWFALAAYNIG 386
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
108-177 4.54e-04

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 39.95  E-value: 4.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176173632 108 LICATITHESAlsWDPQVVSPVGAIGLMQIMPET-GANLAKDEGINWTSAEDVLFDPIINIRLGCRYLSQL 177
Cdd:PRK15470   56 LITAIIAIESG--GNPNAVSKSNAIGLMQLKASTsGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNIL 124
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 113-148 3.23e-03

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 35.08  E-value: 3.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1176173632 113 ITHESALSWDPQVVSPVGAIGLMQIMPETGANLAKD 148
Cdd:cd00442     6 IGQESGGNKPANAGSGSGAAGLFQFMPGTWKAYGKN 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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