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Conserved domains on  [gi|1176173580|gb|OQX88894|]
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DNA-directed RNA polymerase subunit beta [candidate division KSB1 bacterium 4484_87]

Protein Classification

DNA-directed RNA polymerase subunit beta( domain architecture ID 11478603)

DNA-directed RNA polymerase subunit beta catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1266 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


:

Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2135.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580    1 MQKTKRQRKSFSKIQTIVDLPDLLNIQLESFKEFVQPDVPPEkreNKGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKY 80
Cdd:PRK00405     5 YTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPPE---DEGLEEVFRSIFPIEDFNGNLSLEFVSYELGEPKY 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   81 SVDECQERGNTYAAPLKAKLRLSIRDpesdSGEIIdsmEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEM 160
Cdd:PRK00405    82 DVEECKERGLTYSAPLRVKLRLINKE----TGEIK---EQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDHD 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  161 KH--PNDTKIYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYsTDREIYELFDMVEEVGVD-DKKIES 237
Cdd:PRK00405   155 KDktSSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGY-SDEEILDLFYEKEEFGKEiEVPVEY 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  238 YFGKTVLMDVIDYETGEILLEKDSTLDQESlanlrahhiekvkfvksESPYspeiINNTIRKDPTKSEKEALEMIYRHLR 317
Cdd:PRK00405   234 LLGKVLAEDIVDEETGEVLAEANDEITEEL-----------------DGPY----IRNTLEKDPTSSREEALVEIYRRLR 292
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  318 SGDAPDLETARNLVFRFFFNPKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNR 397
Cdd:PRK00405   293 PGEPPTVEAARSLLENLFFDPKRYDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNR 372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  398 RIKTVGEQLAAQMSVGLSRLARTVKERMNLRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLS 477
Cdd:PRK00405   373 RVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLS 452
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  478 ALGPGGLTRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRVTDEIHYLSADDE 557
Cdd:PRK00405   453 ALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEE 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  558 ENLRVAQANAPIDEKGNFINDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVP 637
Cdd:PRK00405   533 DNYVIAQANAPLDEDGRFVDELVTARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVP 612
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  638 LLKPEAPIVGTGVEAKVALDSRAMIVCRRSGVVERVDATKIVVRADDLDAdaelnveslldfDSDETDVYPLQKFKRSNQ 717
Cdd:PRK00405   613 LLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRVEELDP------------GEDGVDIYNLIKFQRSNQ 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  718 DTCTNQIPLVREGDRVQKGDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVR 797
Cdd:PRK00405   681 NTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEAR 760
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  798 DTKRGEEELTREIPNVSEEATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAP 877
Cdd:PRK00405   761 DTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVP 840
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  878 TGLHGTVIATKLFSRkkrdaknkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvl 957
Cdd:PRK00405   841 HGEEGTVIDVKVFTR----------------------------------------------------------------- 855
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  958 kkdllenldfdaldltrplvddaernelvaeileqyykkldslqedyenqkfkVTVGDELPPGIVQMAKVYVAKKRKLMI 1037
Cdd:PRK00405   856 -----------------------------------------------------IEQGDELPPGVNKLVKVYIAQKRKIQV 882
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1038 GDKMAGRHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGASLEEVQ 1117
Cdd:PRK00405   883 GDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIKFATPVFDGAKEEEIK 962
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1118 TEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVW 1197
Cdd:PRK00405   963 ELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVW 1042
                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173580 1198 ALEAYGAAHTLQEILTVKSDDVRGRSKAYEAIVKGESLPDPGVPESFNVLIRELMGLGLDVELLNLKDE 1266
Cdd:PRK00405  1043 ALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVELLDEDGN 1111
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1266 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2135.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580    1 MQKTKRQRKSFSKIQTIVDLPDLLNIQLESFKEFVQPDVPPEkreNKGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKY 80
Cdd:PRK00405     5 YTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPPE---DEGLEEVFRSIFPIEDFNGNLSLEFVSYELGEPKY 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   81 SVDECQERGNTYAAPLKAKLRLSIRDpesdSGEIIdsmEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEM 160
Cdd:PRK00405    82 DVEECKERGLTYSAPLRVKLRLINKE----TGEIK---EQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDHD 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  161 KH--PNDTKIYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYsTDREIYELFDMVEEVGVD-DKKIES 237
Cdd:PRK00405   155 KDktSSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGY-SDEEILDLFYEKEEFGKEiEVPVEY 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  238 YFGKTVLMDVIDYETGEILLEKDSTLDQESlanlrahhiekvkfvksESPYspeiINNTIRKDPTKSEKEALEMIYRHLR 317
Cdd:PRK00405   234 LLGKVLAEDIVDEETGEVLAEANDEITEEL-----------------DGPY----IRNTLEKDPTSSREEALVEIYRRLR 292
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  318 SGDAPDLETARNLVFRFFFNPKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNR 397
Cdd:PRK00405   293 PGEPPTVEAARSLLENLFFDPKRYDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNR 372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  398 RIKTVGEQLAAQMSVGLSRLARTVKERMNLRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLS 477
Cdd:PRK00405   373 RVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLS 452
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  478 ALGPGGLTRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRVTDEIHYLSADDE 557
Cdd:PRK00405   453 ALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEE 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  558 ENLRVAQANAPIDEKGNFINDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVP 637
Cdd:PRK00405   533 DNYVIAQANAPLDEDGRFVDELVTARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVP 612
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  638 LLKPEAPIVGTGVEAKVALDSRAMIVCRRSGVVERVDATKIVVRADDLDAdaelnveslldfDSDETDVYPLQKFKRSNQ 717
Cdd:PRK00405   613 LLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRVEELDP------------GEDGVDIYNLIKFQRSNQ 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  718 DTCTNQIPLVREGDRVQKGDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVR 797
Cdd:PRK00405   681 NTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEAR 760
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  798 DTKRGEEELTREIPNVSEEATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAP 877
Cdd:PRK00405   761 DTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVP 840
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  878 TGLHGTVIATKLFSRkkrdaknkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvl 957
Cdd:PRK00405   841 HGEEGTVIDVKVFTR----------------------------------------------------------------- 855
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  958 kkdllenldfdaldltrplvddaernelvaeileqyykkldslqedyenqkfkVTVGDELPPGIVQMAKVYVAKKRKLMI 1037
Cdd:PRK00405   856 -----------------------------------------------------IEQGDELPPGVNKLVKVYIAQKRKIQV 882
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1038 GDKMAGRHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGASLEEVQ 1117
Cdd:PRK00405   883 GDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIKFATPVFDGAKEEEIK 962
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1118 TEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVW 1197
Cdd:PRK00405   963 ELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVW 1042
                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173580 1198 ALEAYGAAHTLQEILTVKSDDVRGRSKAYEAIVKGESLPDPGVPESFNVLIRELMGLGLDVELLNLKDE 1266
Cdd:PRK00405  1043 ALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVELLDEDGN 1111
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
4-1260 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1846.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580    4 TKRQRKSFSKIQTIVDLPDLLNIQLESFKEFVQPDVPPEKRENKGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKYSVD 83
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPPEKRKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   84 ECQERGNTYAAPLKAKLRLSIRDpESDSGEIIdsmEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEMK-- 161
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINKE-EDGTKEIK---EQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKdt 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  162 HPNDTKIYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYSTDREIYELFDmveevgvddkkiesyfgk 241
Cdd:TIGR02013  157 TKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLILNRLG------------------ 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  242 tvlmdvidyetgeillekdstldqeslanlrahhiekvkfvksespySPEIINNTIRKDPTKSEKEALEMIYRHLRSGDA 321
Cdd:TIGR02013  219 -----------------------------------------------SGEYIRNTLRKDPTNSEEEALVEIYRKLRPGEP 251
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  322 PDLETARNLVFRFFFNPKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNRRIKT 401
Cdd:TIGR02013  252 PTVEAARSLLENLFFDPKRYDLGRVGRYKLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRS 331
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  402 VGEQLAAQMSVGLSRLARTVKERMNLRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLSALGP 481
Cdd:TIGR02013  332 VGELLQNQFRVGLARMERIVRERMSTQDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGP 411
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  482 GGLTRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRV--TDEIHYLSADDEEN 559
Cdd:TIGR02013  412 GGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEEDN 491
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  560 LRVAQANAPIDEKGNFINDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVPLL 639
Cdd:TIGR02013  492 YVIAQANAPLDENGRFVEDLVVARYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLL 571
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  640 KPEAPIVGTGVEAKVALDSRAMIVCRRSGVVERVDATKIVVRADDLDADAELNVeslldfdsdetDVYPLQKFKRSNQDT 719
Cdd:TIGR02013  572 RSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRYDEDEEEPDGGI-----------DIYRLLKYQRSNQDT 640
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  720 CTNQIPLVREGDRVQKGDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDT 799
Cdd:TIGR02013  641 CINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDT 720
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  800 KRGEEELTREIPNVSEEATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAPTG 879
Cdd:TIGR02013  721 KLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPG 800
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  880 LHGTVIATKLFSRKKrdaknkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvlkk 959
Cdd:TIGR02013  801 VEGTVIDVKVFSREQ----------------------------------------------------------------- 815
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  960 dllenldfdaldltrplvddaernelvaeileqyykkldslqedyenqkfkvtvGDELPPGIVQMAKVYVAKKRKLMIGD 1039
Cdd:TIGR02013  816 ------------------------------------------------------GDELPPGVNKLVKVYIAQKRKIQVGD 841
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1040 KMAGRHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILD---VMYSTPVFDGASLEEV 1116
Cdd:TIGR02013  842 KMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGrkgVPIATPVFDGASEEEI 921
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1117 QTEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEV 1196
Cdd:TIGR02013  922 KEYLEKAGLPRDGKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEV 1001
                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176173580 1197 WALEAYGAAHTLQEILTVKSDDVRGRSKAYEAIVKGESLPDPGVPESFNVLIRELMGLGLDVEL 1260
Cdd:TIGR02013 1002 WALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
8-1262 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1737.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580    8 RKSFSKIQTIVDLPDLLNIQLESFKEFVqpdvppekreNKGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKYSVDECQE 87
Cdd:COG0085      1 RWSFAKIKEPLELPNLLEIQLDSFNWFL----------EEGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKE 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   88 RGNTYAAPLKAKLRLSirdpESDSGEIIdsmEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEMKHPNDTK 167
Cdd:COG0085     71 RDLTYAAPLYVKVRLV----NKETGEIK---EQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDKSGKD 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  168 IYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYSTDREIYELFDmveevgvddkkiesyfgktvlmDV 247
Cdd:COG0085    144 LYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLETDEEILEAFG----------------------DD 201
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  248 IDYEtgeillekdstldqeslanlrahhiekvkfvksespyspeIINNTIRKDPTKSEKEALEMIYRHLRSGDAPDLETA 327
Cdd:COG0085    202 PIQE----------------------------------------YILATLEKDNTKTQEEALLEIYRKLRPGEPPTIERA 241
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  328 RNLVFRFFFNPKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNRRIKTVGEQLA 407
Cdd:COG0085    242 EQLLDNLFFDPKRYDLAHVGRYKINKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQ 321
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  408 AQMSVGLSRLARTVKERMNLRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLSALGPGGLTRE 487
Cdd:COG0085    322 NQFRVGLSRMERVVRERMTTQDVEAITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRE 401
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  488 RAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRVTDEIHYLSADDEENLRVAQANA 567
Cdd:COG0085    402 RAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANA 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  568 PIDEKGNFINDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVPLLKPEAPIvg 647
Cdd:COG0085    482 PLDEDGNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAPL-- 559
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  648 tgveakvaldsramivcrrsgvvervdatkivvraddldadaelnveslldfdsdetDVYPLQKFKRSNQDTCTNQIPLV 727
Cdd:COG0085    560 ---------------------------------------------------------LHYPLQKFQRSNQGTCINQRPIV 582
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  728 REGDRVQKGDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDTKRGEEELT 807
Cdd:COG0085    583 RVGDRVEKGDVLADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEIT 662
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  808 REIPNVSEEATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAPTGLHGTVIAT 887
Cdd:COG0085    663 RDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDV 742
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  888 KLFSRKKrdaknkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvlkkdllenldf 967
Cdd:COG0085    743 KVFSREE------------------------------------------------------------------------- 749
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  968 daldltrplvddaernelvaeileqyykkldslqedyenqkfkvtvGDELPPGIVQMAKVYVAKKRKLMIGDKMAGRHGN 1047
Cdd:COG0085    750 ----------------------------------------------GDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGN 783
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1048 KGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGASLEEVQTEMEEAGLPR 1127
Cdd:COG0085    784 KGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEEIRELLEKAGLPP 863
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1128 DGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHT 1207
Cdd:COG0085    864 DGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYT 943
                         1210      1220      1230      1240      1250
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1176173580 1208 LQEILTVKSDDVRGRSKAYEAIVKGESLPDPGVPESFNVLIRELMGLGLDVELLN 1262
Cdd:COG0085    944 LQERLTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLGLDVEVLS 998
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
23-1260 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 906.17  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   23 LLNIQLESFKEFVqpdvppekreNKGLQAVFNSIFPIED--SRENFVLDFISYYLEKP---------KYSVDECQERGNT 91
Cdd:cd00653      1 LVKQQIDSFNYFL----------NVGLQEIVKSIPPITDtdDDGRLKLKFGDIYLGKPkveeggvtrKLTPNECRLRDLT 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   92 YAAPLKAKLRLSIRDpesdsgeIIDSMEQTVYLGNIPMMTE------------------------KGTFIINGAERIVVS 147
Cdd:cd00653     71 YSAPLYVDIRLTVND-------KGKIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIIN 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  148 QLHRSPGAFFDEmkHPNDTKIYSARIIP----LRGSWLEFVTDI-NDVMYFYIDRRKKfpvttllraigystdreiyelf 222
Cdd:cd00653    144 QEQRSPNVIIVE--DSKGKRIYTKTSIPsyspYRGSWLEVKSDKkKDRIYVRIDLKRQ---------------------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  223 dmveevgvddkkiesyfgktvlmdvidyetgeillekdstldqeslanlrahhiekvkfvksespyspeiinntirkdpt 302
Cdd:cd00653        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  303 kseKEALEMIYRHLrsgdapdletarnlvfrfffnpkrydlgevgryrlnnklglsidpdvtvltkEDIIAIINYLLDLR 382
Cdd:cd00653    200 ---EEALKYIGKRF----------------------------------------------------EDLIYMIRKLILLV 224
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  383 NGKIQADDIDHLGNRRIKTVGEQLAAQMSVGLSRLARTVKERMN--LRDNEELTPQDLVNARTILSVINTFFGTSQ---- 456
Cdd:cd00653    225 LGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQkqLSKKKDLTPQLLINSKPITSGIKEFLATGNwgsk 304
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  457 --------LSQFMDQTNPLAEMTHKRRLSAlgpGGLTRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRIN 528
Cdd:cd00653    305 rflmqrsgLSQVLDRLNPLSELSHKRRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS 381
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  529 klGFIETPYRKVVdgrvtdeihylsaddeenlrvaqanapidekgnfindrvqvrfrgdfplvtpKEVDYMDVSPTQMVS 608
Cdd:cd00653    382 --GRIERPYRIVE----------------------------------------------------KEVTHIEISPSQILS 407
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  609 AAASLIPFLEHDDANRALMGSNMQRQSVP----------------LLKPEAPIVGTGVEAKVALdsramivcrrsgvver 672
Cdd:cd00653    408 VAASLIPFPEHNQSPRNLYQSNMQKQAVGtpalnqqyrmdtklylLLYPQKPLVGTGIEEYIAF---------------- 471
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  673 vdatkivvraddldadaelnveslldfdsdetdvyplqkfkrsnqdtctnqiplvregdrvqkgdvladgcategGELAL 752
Cdd:cd00653    472 ---------------------------------------------------------------------------GELPL 476
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  753 GRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDTKRGEEELTR-EIPNVSEEATKDLDENGIIRVGA 831
Cdd:cd00653    477 GQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGA 556
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  832 EVHEGDILVGKVTPKGETDPTPeekllkaIFGEKAGDVKDASLKAPTGLHGTVIATKLFSRkkrdaknkrlekkelekve 911
Cdd:cd00653    557 RVEPGDILVGKITPKGETESTP-------IFGEKARDVRDTSLKYPGGEKGIVDDVKIFSR------------------- 610
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  912 kwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvlkkdllenldfdaldltrplvddaernelvaeile 991
Cdd:cd00653        --------------------------------------------------------------------------------
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  992 qyykkldslqedyenqkfkvtvgdELPPGIVQMAKVYVAKKRKLMIGDKMAGRHGNKGVVATIVPVEDMPFLPDGTPVDI 1071
Cdd:cd00653    611 ------------------------ELNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDI 666
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1072 VLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGASLEEVQTEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFI 1151
Cdd:cd00653    667 ILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGLNYYGKEVLYDGRTGEPLEAPIFVGPV 746
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1152 YIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVRGRSKAYEAIV- 1230
Cdd:cd00653    747 YYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIIl 826
                         1290      1300      1310
                   ....*....|....*....|....*....|....*....
gi 1176173580 1231 ---------KGESLPDPGVPESFNVLIRELMGLGLDVEL 1260
Cdd:cd00653    827 sanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRL 865
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
663-1185 9.18e-163

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 489.73  E-value: 9.18e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  663 VCRRSGVVERVDATKIVVRADdldadaelnveslldFDSDETDVYPLQKFKRSNQDT---CTNQIPLVREGdRVQKGDVl 739
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCA---------------MGKQAMGIYTLNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGGF- 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  740 adgcategGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEvlETQVRDTKRGE-EELTREIPNVSEEAT 818
Cdd:pfam00562   64 --------GELPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIK--EIEARKTKLGPiEEITRDIPNVSEEAL 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  819 KDLDENGIIRVGAEVHEGDILVGKVtpkGETDPTpeeKLLKAIFGEKAGDVKDASLKAPTGLHGTVIATKLFsrkkrdak 898
Cdd:pfam00562  134 KKLDEDGIVRVGAEVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVF-------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  899 nkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvlkkdllenldfdaldltrplvd 978
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  979 daernelvaeileqyykkldslqedyenqkfkvtvgdELPPGIVQMAKVYVAKKRKLMIGDKMAGRHGNKGVVATIVPVE 1058
Cdd:pfam00562  200 -------------------------------------ELPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQE 242
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1059 DMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGAS--LEEVQTEMEEAGLPRDGKSILFDG 1136
Cdd:pfam00562  243 DMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFDGASteVEDIGELLEKAGYNYYGKEVLYDG 322
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1176173580 1137 RTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQ 1185
Cdd:pfam00562  323 RTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1266 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2135.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580    1 MQKTKRQRKSFSKIQTIVDLPDLLNIQLESFKEFVQPDVPPEkreNKGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKY 80
Cdd:PRK00405     5 YTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPPE---DEGLEEVFRSIFPIEDFNGNLSLEFVSYELGEPKY 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   81 SVDECQERGNTYAAPLKAKLRLSIRDpesdSGEIIdsmEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEM 160
Cdd:PRK00405    82 DVEECKERGLTYSAPLRVKLRLINKE----TGEIK---EQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDHD 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  161 KH--PNDTKIYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYsTDREIYELFDMVEEVGVD-DKKIES 237
Cdd:PRK00405   155 KDktSSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGY-SDEEILDLFYEKEEFGKEiEVPVEY 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  238 YFGKTVLMDVIDYETGEILLEKDSTLDQESlanlrahhiekvkfvksESPYspeiINNTIRKDPTKSEKEALEMIYRHLR 317
Cdd:PRK00405   234 LLGKVLAEDIVDEETGEVLAEANDEITEEL-----------------DGPY----IRNTLEKDPTSSREEALVEIYRRLR 292
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  318 SGDAPDLETARNLVFRFFFNPKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNR 397
Cdd:PRK00405   293 PGEPPTVEAARSLLENLFFDPKRYDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNR 372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  398 RIKTVGEQLAAQMSVGLSRLARTVKERMNLRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLS 477
Cdd:PRK00405   373 RVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLS 452
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  478 ALGPGGLTRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRVTDEIHYLSADDE 557
Cdd:PRK00405   453 ALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEE 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  558 ENLRVAQANAPIDEKGNFINDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVP 637
Cdd:PRK00405   533 DNYVIAQANAPLDEDGRFVDELVTARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVP 612
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  638 LLKPEAPIVGTGVEAKVALDSRAMIVCRRSGVVERVDATKIVVRADDLDAdaelnveslldfDSDETDVYPLQKFKRSNQ 717
Cdd:PRK00405   613 LLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRVEELDP------------GEDGVDIYNLIKFQRSNQ 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  718 DTCTNQIPLVREGDRVQKGDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVR 797
Cdd:PRK00405   681 NTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEAR 760
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  798 DTKRGEEELTREIPNVSEEATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAP 877
Cdd:PRK00405   761 DTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVP 840
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  878 TGLHGTVIATKLFSRkkrdaknkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvl 957
Cdd:PRK00405   841 HGEEGTVIDVKVFTR----------------------------------------------------------------- 855
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  958 kkdllenldfdaldltrplvddaernelvaeileqyykkldslqedyenqkfkVTVGDELPPGIVQMAKVYVAKKRKLMI 1037
Cdd:PRK00405   856 -----------------------------------------------------IEQGDELPPGVNKLVKVYIAQKRKIQV 882
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1038 GDKMAGRHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGASLEEVQ 1117
Cdd:PRK00405   883 GDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIKFATPVFDGAKEEEIK 962
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1118 TEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVW 1197
Cdd:PRK00405   963 ELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVW 1042
                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173580 1198 ALEAYGAAHTLQEILTVKSDDVRGRSKAYEAIVKGESLPDPGVPESFNVLIRELMGLGLDVELLNLKDE 1266
Cdd:PRK00405  1043 ALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVELLDEDGN 1111
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
4-1260 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1846.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580    4 TKRQRKSFSKIQTIVDLPDLLNIQLESFKEFVQPDVPPEKRENKGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKYSVD 83
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPPEKRKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   84 ECQERGNTYAAPLKAKLRLSIRDpESDSGEIIdsmEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEMK-- 161
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINKE-EDGTKEIK---EQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKdt 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  162 HPNDTKIYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYSTDREIYELFDmveevgvddkkiesyfgk 241
Cdd:TIGR02013  157 TKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLILNRLG------------------ 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  242 tvlmdvidyetgeillekdstldqeslanlrahhiekvkfvksespySPEIINNTIRKDPTKSEKEALEMIYRHLRSGDA 321
Cdd:TIGR02013  219 -----------------------------------------------SGEYIRNTLRKDPTNSEEEALVEIYRKLRPGEP 251
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  322 PDLETARNLVFRFFFNPKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNRRIKT 401
Cdd:TIGR02013  252 PTVEAARSLLENLFFDPKRYDLGRVGRYKLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRS 331
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  402 VGEQLAAQMSVGLSRLARTVKERMNLRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLSALGP 481
Cdd:TIGR02013  332 VGELLQNQFRVGLARMERIVRERMSTQDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGP 411
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  482 GGLTRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRV--TDEIHYLSADDEEN 559
Cdd:TIGR02013  412 GGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEEDN 491
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  560 LRVAQANAPIDEKGNFINDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVPLL 639
Cdd:TIGR02013  492 YVIAQANAPLDENGRFVEDLVVARYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLL 571
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  640 KPEAPIVGTGVEAKVALDSRAMIVCRRSGVVERVDATKIVVRADDLDADAELNVeslldfdsdetDVYPLQKFKRSNQDT 719
Cdd:TIGR02013  572 RSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRYDEDEEEPDGGI-----------DIYRLLKYQRSNQDT 640
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  720 CTNQIPLVREGDRVQKGDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDT 799
Cdd:TIGR02013  641 CINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDT 720
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  800 KRGEEELTREIPNVSEEATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAPTG 879
Cdd:TIGR02013  721 KLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPG 800
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  880 LHGTVIATKLFSRKKrdaknkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvlkk 959
Cdd:TIGR02013  801 VEGTVIDVKVFSREQ----------------------------------------------------------------- 815
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  960 dllenldfdaldltrplvddaernelvaeileqyykkldslqedyenqkfkvtvGDELPPGIVQMAKVYVAKKRKLMIGD 1039
Cdd:TIGR02013  816 ------------------------------------------------------GDELPPGVNKLVKVYIAQKRKIQVGD 841
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1040 KMAGRHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILD---VMYSTPVFDGASLEEV 1116
Cdd:TIGR02013  842 KMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGrkgVPIATPVFDGASEEEI 921
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1117 QTEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEV 1196
Cdd:TIGR02013  922 KEYLEKAGLPRDGKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEV 1001
                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176173580 1197 WALEAYGAAHTLQEILTVKSDDVRGRSKAYEAIVKGESLPDPGVPESFNVLIRELMGLGLDVEL 1260
Cdd:TIGR02013 1002 WALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
8-1262 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1737.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580    8 RKSFSKIQTIVDLPDLLNIQLESFKEFVqpdvppekreNKGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKYSVDECQE 87
Cdd:COG0085      1 RWSFAKIKEPLELPNLLEIQLDSFNWFL----------EEGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKE 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   88 RGNTYAAPLKAKLRLSirdpESDSGEIIdsmEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEMKHPNDTK 167
Cdd:COG0085     71 RDLTYAAPLYVKVRLV----NKETGEIK---EQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDKSGKD 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  168 IYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYSTDREIYELFDmveevgvddkkiesyfgktvlmDV 247
Cdd:COG0085    144 LYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLETDEEILEAFG----------------------DD 201
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  248 IDYEtgeillekdstldqeslanlrahhiekvkfvksespyspeIINNTIRKDPTKSEKEALEMIYRHLRSGDAPDLETA 327
Cdd:COG0085    202 PIQE----------------------------------------YILATLEKDNTKTQEEALLEIYRKLRPGEPPTIERA 241
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  328 RNLVFRFFFNPKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNRRIKTVGEQLA 407
Cdd:COG0085    242 EQLLDNLFFDPKRYDLAHVGRYKINKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQ 321
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  408 AQMSVGLSRLARTVKERMNLRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLSALGPGGLTRE 487
Cdd:COG0085    322 NQFRVGLSRMERVVRERMTTQDVEAITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRE 401
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  488 RAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRVTDEIHYLSADDEENLRVAQANA 567
Cdd:COG0085    402 RAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANA 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  568 PIDEKGNFINDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVPLLKPEAPIvg 647
Cdd:COG0085    482 PLDEDGNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAPL-- 559
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  648 tgveakvaldsramivcrrsgvvervdatkivvraddldadaelnveslldfdsdetDVYPLQKFKRSNQDTCTNQIPLV 727
Cdd:COG0085    560 ---------------------------------------------------------LHYPLQKFQRSNQGTCINQRPIV 582
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  728 REGDRVQKGDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDTKRGEEELT 807
Cdd:COG0085    583 RVGDRVEKGDVLADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEIT 662
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  808 REIPNVSEEATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAPTGLHGTVIAT 887
Cdd:COG0085    663 RDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDV 742
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  888 KLFSRKKrdaknkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvlkkdllenldf 967
Cdd:COG0085    743 KVFSREE------------------------------------------------------------------------- 749
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  968 daldltrplvddaernelvaeileqyykkldslqedyenqkfkvtvGDELPPGIVQMAKVYVAKKRKLMIGDKMAGRHGN 1047
Cdd:COG0085    750 ----------------------------------------------GDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGN 783
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1048 KGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGASLEEVQTEMEEAGLPR 1127
Cdd:COG0085    784 KGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEEIRELLEKAGLPP 863
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1128 DGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHT 1207
Cdd:COG0085    864 DGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYT 943
                         1210      1220      1230      1240      1250
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1176173580 1208 LQEILTVKSDDVRGRSKAYEAIVKGESLPDPGVPESFNVLIRELMGLGLDVELLN 1262
Cdd:COG0085    944 LQERLTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLGLDVEVLS 998
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
6-1269 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 1218.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580    6 RQRKSFSKIQTIVDLPDLLNIQLESFKEFVQPDvppEKRENkGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKYSVDEC 85
Cdd:PRK09603    10 RLRADFTKTPTDLEVPNLLLLQRDSYDSFLYSK---DGKES-GIEKVFKSIFPIQDEHNRITLEYAGCEFGKSKYTVREA 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   86 QERGNTYAAPLKAKLRLSIRDPESDSGE---IIDSMEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEMKH 162
Cdd:PRK09603    86 MERGITYSIPLKIKVRLILWEKDTKSGEkngIKDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSPGVIFKEEES 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  163 PNDTK--IYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYSTdREIYELFDMVEEVGVDDKKI----- 235
Cdd:PRK09603   166 STSLNklIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDYQK-QDIIKMFYPLVKVRYENDKYlipfa 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  236 ESYFGKTVLMDVIDYEtGEILLEKDSTLDQESLANLRAHHIEKV---------KFVKSESPYSPEIINNTIRK-DPTKSE 305
Cdd:PRK09603   245 SLDANQRMEFDLKDPQ-GKIILLAGKKLTSRKIKELKENHLEWVeypmdillnRHLAEPVMVGKEVLLDMLTQlDKNKLE 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  306 K-------------------------------EALEM-----------------IYRHLRSGDAPDLETARNLVFRFFFN 337
Cdd:PRK09603   324 KihdlgvqefviindlalghdasiihsfsadsESLKLlkqtekiddenalaairIHKVMKPGDPVTTEVAKQFVKKLFFD 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  338 PKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNRRIKTVGEQLAAQMSVGLSRL 417
Cdd:PRK09603   404 PERYDLTMVGRMKMNHKLGLHVPDYITTLTHEDIITTVKYLMKIKNNQGKIDDRDHLGNRRIRAVGELLANELHSGLVKM 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  418 ARTVKERMNLRDN--EELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLSALGPGGLTRERAGFEVRD 495
Cdd:PRK09603   484 QKTIKDKLTTMSGafDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKDRVGFEARD 563
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  496 VHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRVTDEIHYLSADDEENLRVAQANAPIDEKGNF 575
Cdd:PRK09603   564 VHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKVVDGKVVGETIYLTAIQEDSHIIAPASTPIDEEGNI 643
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  576 INDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVPLLKPEAPIVGTGVEAKVA 655
Cdd:PRK09603   644 LGDLIETRVEGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIVGTGIEKIIA 723
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  656 LDSRAMIVCRRSGVVERVDATKIVVRADDlDADAELnveslldfdsdetDVYPLQKFKRSNQDTCTNQIPLVREGDRVQK 735
Cdd:PRK09603   724 RDSWGAIKANRAGVVEKIDSKNIYILGEG-KEEAYI-------------DAYSLQKNLRTNQNTSFNQVPIVKVGDKVEA 789
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  736 GDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDTKRGEEELTREIPNVSE 815
Cdd:PRK09603   790 GQIIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSTHIYEKEVDARELKHGVEEFTADIPDVKE 869
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  816 EATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAPTGLHGTVIATKLFSRKKR 895
Cdd:PRK09603   870 EALAHLDESGIVKVGTYVSAGMILVGKTSPKGEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKVFTKKGY 949
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  896 DaKNKRLEKKelekvekwYTAEKQRI-----KRL----RDKKLRRVLLDQKSAGISELD-GGKVVVRAKTVLKKDL--LE 963
Cdd:PRK09603   950 E-KDARVLSA--------YEEEKAKLdmehfDRLtmlnREELLRVSSLLSQAILEEPFShNGKDYKEGDQIPKEEIasIN 1020
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  964 NLDFDALDLTRPLVDDAERNELVAEILEQyyKKldSLQEDYENQKFKVTVGDELPPGIVQMAKVYVAKKRKLMIGDKMAG 1043
Cdd:PRK09603  1021 RFTLASLVKKYSKEVQNHYEITKNNFLEQ--KK--VLGEEHEEKLSILEKDDILPNGVIKKVKLYIATKRKLKVGDKMAG 1096
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1044 RHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKIL------------------------ 1099
Cdd:PRK09603  1097 RHGNKGIVSNIVPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFgkqiasmledktkdfakelrakml 1176
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1100 ----------------------------------DVMYSTPVFDGASLEEVQTEMEEAGLPRDGKSILFDGRTGEQFDNP 1145
Cdd:PRK09603  1177 eianainekdpltihalencsdeelleyakdwskGVKMAIPVFEGISQEKFYKLFELAKIAMDGKMDLYDGRTGEKMRER 1256
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1146 VTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVRGRSKA 1225
Cdd:PRK09603  1257 VNVGYMYMIKLHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENA 1336
                         1370      1380      1390      1400
                   ....*....|....*....|....*....|....*....|....*
gi 1176173580 1226 YEAIVKGESLPDPGVPESFNVLIRELMGLGLDVELL-NLKDEGGI 1269
Cdd:PRK09603  1337 YRAIAKGEQVGESEIPETFYVLTKELQSLALDINIFgDDVDEDGA 1381
rpoB CHL00207
RNA polymerase beta subunit; Provisional
20-1265 0e+00

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 1153.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   20 LPDLLNIQLESFKEFVqpdvppekreNKGLQAVFNSIFPIEDSRENFVLDFIS--YYLEKPKYSVDECQERGNTYAA--P 95
Cdd:CHL00207     7 LPDFLEIQRTSFCWFL----------NEGLNEELNIFSKIFDYTGNLELLLFGknYKLKYPKYNLLSAKSYDSNYSIqiY 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   96 LKAKLRlsirdpESDSGEIIdsmEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEMKHPNDTKIYSARIIP 175
Cdd:CHL00207    77 LPLKFI------NLKTNKIK---FINYLIGNLPKMTQRGTFIINGLERVIVSQIIRSPGIYFKKEIKKNSNKIYSATLIP 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  176 LRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYStdreiyelfdmveevgvddkkiesyfgktvlmdvidyetgei 255
Cdd:CHL00207   148 NRGSWIKFELDKNKEIWIRIDKNRKKPLIIFLKALGLT------------------------------------------ 185
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  256 llekdstlDQESLANLRAHhiekvkfvksespYSPEIINNTIRKDPTKSEKEALEMIYRHLRSGDAPDLETARNLVFRFF 335
Cdd:CHL00207   186 --------DQDIYSRLTKS-------------EFLKKLKPILLNSNSYTNEEILLEIYKNLSPIEPATVNDANQNLFSRF 244
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  336 FNPKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNRRIKTVGEQLAAQMSVGLS 415
Cdd:CHL00207   245 FDPKNYDLGKVGRYKINNKLNLNIPERVRNLTYEDILSIIDKLINLKINKGNFDDIDHLKNRRVRSVGELLQNQFRIGLK 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  416 RLARTVKERMNLRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLSALGPGGLTRERAGFEVRD 495
Cdd:CHL00207   325 RLERILRNRMTICDIDSLSKFNLINPKPLIALIREFFGSSQLSQYMDQTNPLSELTHKRRISILGPGGLDKDRISFAVRD 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  496 VHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRV--TDEIHYLSADDEENLRVAQANAPIDEKG 573
Cdd:CHL00207   405 IHPSHYGRICPIETPEGPNCGLIGSLATNARINKFGFIETPFYKVINGKVkkFGNPIYLTADSEDLYRIAPNDINLNKNN 484
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  574 NFINDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVPLLKPEAPIVGTGVEAK 653
Cdd:CHL00207   485 YFKKNIIPVRYKQEFKTVNPSKVDFIAISPIQVFSIAESLIPFLEHNDANRALMGSNMQRQAVPLLYPEKPIVGTGYEKQ 564
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  654 VALDSRAMIVCRRSGVVERVDATKIVVRAddldadaelnveslldfDSDETDVYPLQKFKRSNQDTCTNQIPLVREGDRV 733
Cdd:CHL00207   565 IALDSGMTIISLTEGIVVSVSAYKIIIQD-----------------DNNRYIHYYLQKYQRSNQNTCINYRPIVWVGEKI 627
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  734 QKGDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDTKRGEEELTREIPNV 813
Cdd:CHL00207   628 NIGQILADGSDIDNSELALGQNVLVAYMPWEGYNFEDAILINKRLVYEDLFTSIHIEKYEIELRQTKLGSEEITRNIPNV 707
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  814 SEEATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAPTGLHGTVIATKLFSRK 893
Cdd:CHL00207   708 SEYSLKNLDENGIISIGSKVLAGDILVGKITPKGESDQLPEGKLLRAIFGEKAKDVKDTSLRMPNGGYGRVIKVEIFSRS 787
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  894 Krdaknkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvlkkdllenldfdaldlt 973
Cdd:CHL00207   788 K------------------------------------------------------------------------------- 788
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  974 rplvddaernelvaeileqyykkldslqedyenqkfkvtvGDELPPGIVQMAKVYVAKKRKLMIGDKMAGRHGNKGVVAT 1053
Cdd:CHL00207   789 ----------------------------------------GDELKFGYYLKIRVFIAQIRKIQVGDKLAGRHGNKGIISR 828
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1054 IVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGAS------------LEEVQTEME 1121
Cdd:CHL00207   829 ILPRQDMPYLPDGTPPDIILNPLGVPSRMNVGQLFECLLGLAGDNLNKRFKILPFDEMYgseysrilinnkLNQASIKNN 908
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1122 EAGLPRD---GKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWA 1198
Cdd:CHL00207   909 EYWLFNSyhpGKMVLRDGRTGYKFKNPVTVGIAYMLKLIHLVDDKIHARTTGPYSLVTQQPLGGKAQHGGQRFGEMEVWA 988
                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176173580 1199 LEAYGAAHTLQEILTVKSDDVRGRSKAYEAIVKGESLPDPGVPESFNVLIRELMGLGLDVELLNLKD 1265
Cdd:CHL00207   989 LEAFGAAYTLKELLTIKSDDMQGRNETLNAIVKGQPIPKPGTPESFKVLMRELQSLGLDIEAYKIEN 1055
rpoB CHL00001
RNA polymerase beta subunit
20-1259 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1143.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   20 LPDLLNIQLESFKEFVqpdvppekreNKGLQAVFNSIFPIEDSRENFVLDFIS--YYLEKPKYSVDECQERGNTYAAPLK 97
Cdd:CHL00001    12 IPGFNQIQFEGFCRFI----------DQGLTEELSKFPKIEDTDQEIEFQLFVetYQLVEPLIKERDAVYESLTYSSELY 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   98 AKLRLSIRdpesdsgEIIDSMEQTVYLGNIPMMTEKGTFIINGAERIVVSQLHRSPGAFFDEMKHPNDTKIYSARIIPLR 177
Cdd:CHL00001    82 VPAGLIWK-------KSRDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYRSELDHNGISVYTGTIISDW 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  178 GSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGySTDREIyelfdmveevgvddkkiesyfgktvlmdvidyetgeill 257
Cdd:CHL00001   155 GGRLELEIDRKARIWARVSRKQKISILVLLSAMG-LNLREI--------------------------------------- 194
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  258 ekdstldqesLANLRahhiekvkfvksespySPEIINNTIR---KDPTKSEKEALEMIYRHL--RSGDAPDLETARNLVF 332
Cdd:CHL00001   195 ----------LDNVC----------------YPEIFLSFLNdkeKKKIGSKENAILEFYQQFacVGGDPVFSESLCKELQ 248
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  333 RFFFNpKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNRRIKTVGEQLAAQMSV 412
Cdd:CHL00001   249 KKFFQ-QRCELGRIGRRNMNRKLNLDIPENNTFLLPQDVLAAADYLIGMKFGMGTLDDIDHLKNKRIRSVADLLQDQFGL 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  413 GLSRLARTVKERMN--LRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLSALGPGGLTRERAG 490
Cdd:CHL00001   328 ALNRLENAVRGTICgaIRRKLIPTPQNLVTSTPLTTTYESFFGSHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTGRTAS 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  491 FEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRVTDEIHYLSADDEENLRVAQANAPID 570
Cdd:CHL00001   408 FRVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHARIGHWGSLESPFYEISERSKEERMVYLSPSEDEYYMIAAGNSLAL 487
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  571 EKGNFINDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVPLLKPEAPIVGTGV 650
Cdd:CHL00001   488 NQGIQEEQVVPARYRQEFLTIAWEQIHLRSIFPFQYFSIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCIVGTGL 567
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  651 EAKVALDSRAMIVCRRSGVVERVDATKIVVraddldadaelnveslldFDSDETDVYPLQKFKRSNQDTCTNQIPLVREG 730
Cdd:CHL00001   568 ERQVALDSGVVAIAEHEGKIIYTDTDKIIL------------------SGNGDTLSIPLVMYQRSNKNTCMHQKPQVRRG 629
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  731 DRVQKGDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDTKRGEEELTREI 810
Cdd:CHL00001   630 KCVKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITKEI 709
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  811 PNVSEEATKDLDENGIIRVGAEVHEGDILVGKVTPK--GETDPTPEEKLLKAIFGEKAGDVKDASLKAPTGLHGTVIatk 888
Cdd:CHL00001   710 PHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQeaEESSYAPEGRLLRAIFGIQVSTSKETCLKLPIGGRGRVI--- 786
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  889 lfsrkkrDaknkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvVRakTVLKKDLLENldfd 968
Cdd:CHL00001   787 -------D------------------------------------------------------VR--WIQKKGGSSY---- 799
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  969 aldltrplvddaernelvaeileqyykkldslqedyenqkfkvtvgdelppgIVQMAKVYVAKKRKLMIGDKMAGRHGNK 1048
Cdd:CHL00001   800 ----------------------------------------------------NPETIHVYILQKREIQVGDKVAGRHGNK 827
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1049 GVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFD-----GASLEEVQTEMEEA 1123
Cdd:CHL00001   828 GIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVGQIFECLLGLAGDLLNRHYRIAPFDeryeqEASRKLVFSELYEA 907
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1124 GL------------PrdGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRF 1191
Cdd:CHL00001   908 SKqtanpwvfepeyP--GKSRLFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRV 985
                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173580 1192 GEMEVWALEAYGAAHTLQEILTVKSDDVRGRSKAYEAIVKGESLPDP-GVPESFNVLIRELMGLGLDVE 1259
Cdd:CHL00001   986 GEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGAIITGGTIPKPeDAPESFRLLVRELRSLALELN 1054
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
8-1260 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 1128.95  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580    8 RKSFSKIQTIVD-LPDLLNIQLESFKEFVqpdvpPEKRENKGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKYSVDECQ 86
Cdd:PRK14844    16 RVSYSRSIDLKDsLLDLVKVQKESYDSFT-----PKNKGNERLEVIFHTIFPINDPLHRATIEFISCRVDDPKYDESECI 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   87 ERGNTYAAPLKAKLRLSI---------------RDPESDSGEIIDSM-EQTVYLGNIPMMTEKGTFIINGAERIVVSQLH 150
Cdd:PRK14844    91 KRGITFSAQVIASIRLVImqdgisldeyksikeSGDHSKLATVIKSIeEQEVHFCELPMMTDKGTFIINGVEKVIVSQMH 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  151 RSPGAFFD--EMKHPNDTK-IYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYSTD---REIYEL--- 221
Cdd:PRK14844   171 RSPGVFFDsdKGKTYNSGKlIYSARVIPYRGSWLDIEFDVKDHLYFRIDRKRKLPISVLLKALGLSNNdilDRFYEKiky 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  222 ----------------------FDMVEEVG-----------------VDDKKIESYF-------GKTVLMDVIDYETGEI 255
Cdd:PRK14844   251 ikhkdgwkvpfvpdkfkgvrlpFDLMDVEGnvllkanvritsrlakkLYDNELKEYLvpfdsicGLFLAEDLIDSASSTK 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  256 LLEKDSTLDQESLANLRAHHIEKVKFVKSESPYSPEIINNTIRKDPTKSEKEALEMIYRHLRSGDAPDLETARNLVFRFF 335
Cdd:PRK14844   331 ILSAGESIKLEDIKKLELLSIDEISVLNIDNLSVGPYILNTLFLDENMSYQDALYEIYKVLRPGEVPVLEIVEEFFRNLF 410
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  336 FNPKRYDLGEVGRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQADDIDHLGNRRIKTVGEQLAAQMSVGLS 415
Cdd:PRK14844   411 FSPEYYDLSNIGRLKLNSYLGLNYDEDLTVLTHEDIIEIVRKIVLLRDGQGSVDDIDHLGNRRVRSVGEFIENQFRTGLL 490
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  416 RLARTVKERMNLRDNEELTPQDLVNARTILSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLSALGPGGLTRERAGFEVRD 495
Cdd:PRK14844   491 KLERAVVDSMSTSSLDKVSPSDFINPKVLTNVLRDFFNSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRD 570
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  496 VHYTHYGRLCPIETPEGPNIGLISSLTTFGRINKLGFIETPYRKVVDGRVTDEIHYLSADDEENLRVAQANAPIDEKGNF 575
Cdd:PRK14844   571 VHPTHYGRICPIETPEGQNIGLINSLAIYARINKYGFIESPYRKVVNRVVTDQIEYLSAIDEGLYYIADTSAKLDENNCF 650
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  576 INDRVQVRFRGDFPLVTPKEVDYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVPLLKPEAPIVGTGVEAKVA 655
Cdd:PRK14844   651 VDDMLYCRYAGSFVMVSSDQVSYIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLLKPTAPLVATGMESFVA 730
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  656 LDSRAMIVCRRSGVVERVDATKIVVRADDLDADAELNVeslldfdsdetDVYPLQKFKRSNQDTCTNQIPLVREGDRVQK 735
Cdd:PRK14844   731 SGSGAVVLAKRDGIVDSSDSNSIVIRAFDKERVNYLDV-----------DIYHLRKFQRSNHNTCINQKPLVCVGDYVKE 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  736 GDVLADGCATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDTKRGEEELTREIPNVSE 815
Cdd:PRK14844   800 GDVIADGPAINSGELALGQNLLVAFMSWQGYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPLGSEKITRAIPGVNE 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  816 EATKDLDENGIIRVGAEVHEGDILVGKVTPKGETDPTPEEKLLKAIFGEKAGDVKDASLKAPTGLHGTVIATKLFSRKKR 895
Cdd:PRK14844   880 ENLYHLDDSGIVKIGTRVGPGYILVGKVTPKPSLSLPPETKLLMTIFGEKSFDCADSSLYTSPDVEGTVIDVQVFTRRGV 959
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  896 DaKNKRLEKKELEKVEKWytaEKQR------IKRLRDKKLRRVLLDQKSAGISELDGGK------VVVRAKTVLKKdlLE 963
Cdd:PRK14844   960 E-ENERALLIKQKEINDF---EKERdyiinvTSEYFYDELKKLLINSGSQDREKFDSIEreqwwgIGLKNQSISEQ--VK 1033
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  964 NL--DFDaldltrplvddaernELVAEILEQYYKKLDSLQEDYenqkfkvtvgdELPPGIVQMAKVYVAKKRKLMIGDKM 1041
Cdd:PRK14844  1034 SLkkDFD---------------EKVSHAIAQFKRKVEKLHEGY-----------DLPQGVSMSVKVFIAVKHSLQPGDKM 1087
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1042 AGRHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWA--------GKILD------------- 1100
Cdd:PRK14844  1088 AGRHGNKGVISRVVPVEDMPYLEDGTPVDIILNPLGVPSRMNVGQILETHVGWAckklgekvGNILDeinkiksafckgi 1167
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1101 ------------VMY----------------------------------------------------------------- 1103
Cdd:PRK14844  1168 rslnddnftkfaAAYldnkkienidddeitasvlntpnknalndelnelvenylnscksaysnlrnflievyscgsnvsi 1247
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1104 -------------------------STPVFDGASLEEVQTEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFIYIMKLSH 1158
Cdd:PRK14844  1248 cnnirdisdnnliefarklrdgipvAAPVFEGPKDEQIAKLFELAGLDNSGQAVLYDGCSGEKFDRKVTVGYMYMLKLHH 1327
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1159 LVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVRGRSKAYEAIVKGESLPDP 1238
Cdd:PRK14844  1328 LVDGKIHARSVGPYSLVTQQPLGGKSHFGGQRFGEMECWALQAYGAAYTLQEMLTVKSDDINGRVKIYESIIKGDSNFEC 1407
                         1450      1460
                   ....*....|....*....|..
gi 1176173580 1239 GVPESFNVLIRELMGLGLDVEL 1260
Cdd:PRK14844  1408 GIPESFNVMIKELRSLCLNVDL 1429
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
23-1260 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 906.17  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   23 LLNIQLESFKEFVqpdvppekreNKGLQAVFNSIFPIED--SRENFVLDFISYYLEKP---------KYSVDECQERGNT 91
Cdd:cd00653      1 LVKQQIDSFNYFL----------NVGLQEIVKSIPPITDtdDDGRLKLKFGDIYLGKPkveeggvtrKLTPNECRLRDLT 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   92 YAAPLKAKLRLSIRDpesdsgeIIDSMEQTVYLGNIPMMTE------------------------KGTFIINGAERIVVS 147
Cdd:cd00653     71 YSAPLYVDIRLTVND-------KGKIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIIN 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  148 QLHRSPGAFFDEmkHPNDTKIYSARIIP----LRGSWLEFVTDI-NDVMYFYIDRRKKfpvttllraigystdreiyelf 222
Cdd:cd00653    144 QEQRSPNVIIVE--DSKGKRIYTKTSIPsyspYRGSWLEVKSDKkKDRIYVRIDLKRQ---------------------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  223 dmveevgvddkkiesyfgktvlmdvidyetgeillekdstldqeslanlrahhiekvkfvksespyspeiinntirkdpt 302
Cdd:cd00653        --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  303 kseKEALEMIYRHLrsgdapdletarnlvfrfffnpkrydlgevgryrlnnklglsidpdvtvltkEDIIAIINYLLDLR 382
Cdd:cd00653    200 ---EEALKYIGKRF----------------------------------------------------EDLIYMIRKLILLV 224
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  383 NGKIQADDIDHLGNRRIKTVGEQLAAQMSVGLSRLARTVKERMN--LRDNEELTPQDLVNARTILSVINTFFGTSQ---- 456
Cdd:cd00653    225 LGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQkqLSKKKDLTPQLLINSKPITSGIKEFLATGNwgsk 304
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  457 --------LSQFMDQTNPLAEMTHKRRLSAlgpGGLTRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTFGRIN 528
Cdd:cd00653    305 rflmqrsgLSQVLDRLNPLSELSHKRRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS 381
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  529 klGFIETPYRKVVdgrvtdeihylsaddeenlrvaqanapidekgnfindrvqvrfrgdfplvtpKEVDYMDVSPTQMVS 608
Cdd:cd00653    382 --GRIERPYRIVE----------------------------------------------------KEVTHIEISPSQILS 407
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  609 AAASLIPFLEHDDANRALMGSNMQRQSVP----------------LLKPEAPIVGTGVEAKVALdsramivcrrsgvver 672
Cdd:cd00653    408 VAASLIPFPEHNQSPRNLYQSNMQKQAVGtpalnqqyrmdtklylLLYPQKPLVGTGIEEYIAF---------------- 471
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  673 vdatkivvraddldadaelnveslldfdsdetdvyplqkfkrsnqdtctnqiplvregdrvqkgdvladgcategGELAL 752
Cdd:cd00653    472 ---------------------------------------------------------------------------GELPL 476
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  753 GRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDTKRGEEELTR-EIPNVSEEATKDLDENGIIRVGA 831
Cdd:cd00653    477 GQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGA 556
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  832 EVHEGDILVGKVTPKGETDPTPeekllkaIFGEKAGDVKDASLKAPTGLHGTVIATKLFSRkkrdaknkrlekkelekve 911
Cdd:cd00653    557 RVEPGDILVGKITPKGETESTP-------IFGEKARDVRDTSLKYPGGEKGIVDDVKIFSR------------------- 610
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  912 kwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvlkkdllenldfdaldltrplvddaernelvaeile 991
Cdd:cd00653        --------------------------------------------------------------------------------
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  992 qyykkldslqedyenqkfkvtvgdELPPGIVQMAKVYVAKKRKLMIGDKMAGRHGNKGVVATIVPVEDMPFLPDGTPVDI 1071
Cdd:cd00653    611 ------------------------ELNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDI 666
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1072 VLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGASLEEVQTEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFI 1151
Cdd:cd00653    667 ILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGLNYYGKEVLYDGRTGEPLEAPIFVGPV 746
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1152 YIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVRGRSKAYEAIV- 1230
Cdd:cd00653    747 YYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIIl 826
                         1290      1300      1310
                   ....*....|....*....|....*....|....*....
gi 1176173580 1231 ---------KGESLPDPGVPESFNVLIRELMGLGLDVEL 1260
Cdd:cd00653    827 sanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRL 865
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
663-1185 9.18e-163

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 489.73  E-value: 9.18e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  663 VCRRSGVVERVDATKIVVRADdldadaelnveslldFDSDETDVYPLQKFKRSNQDT---CTNQIPLVREGdRVQKGDVl 739
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCA---------------MGKQAMGIYTLNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGGF- 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  740 adgcategGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEvlETQVRDTKRGE-EELTREIPNVSEEAT 818
Cdd:pfam00562   64 --------GELPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIK--EIEARKTKLGPiEEITRDIPNVSEEAL 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  819 KDLDENGIIRVGAEVHEGDILVGKVtpkGETDPTpeeKLLKAIFGEKAGDVKDASLKAPTGLHGTVIATKLFsrkkrdak 898
Cdd:pfam00562  134 KKLDEDGIVRVGAEVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVF-------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  899 nkrlekkelekvekwytaekqrikrlrdkklrrvlldqksagiseldggkvvvraktvlkkdllenldfdaldltrplvd 978
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  979 daernelvaeileqyykkldslqedyenqkfkvtvgdELPPGIVQMAKVYVAKKRKLMIGDKMAGRHGNKGVVATIVPVE 1058
Cdd:pfam00562  200 -------------------------------------ELPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQE 242
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1059 DMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWAGKILDVMYSTPVFDGAS--LEEVQTEMEEAGLPRDGKSILFDG 1136
Cdd:pfam00562  243 DMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFDGASteVEDIGELLEKAGYNYYGKEVLYDG 322
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1176173580 1137 RTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQ 1185
Cdd:pfam00562  323 RTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
23-1266 4.17e-103

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 353.11  E-value: 4.17e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   23 LLNIQLESFKEFVqpdvppekreNKGLQAVFNSIFPIEDSRENFVLDFISYYLEKPKY-SVD---------ECQERGNTY 92
Cdd:PRK08565    14 LVRQHLDSYNDFI----------ERGLQEIVDEFGEIKTEIPGLKIVLGKIRVGEPEIkEADgserpitpmEARLRNLTY 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   93 AAPLKAKLRLSIRDPESDsgeiidsmEQTVYLGNIPMM----------------TEKGT--------FIINGAERIVVSQ 148
Cdd:PRK08565    84 AAPLYLTMIPVENGIEYE--------PEEVKIGDLPIMvkskicplsglspdelIEIGEdpkdpggyFIINGSERVIVSQ 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  149 LHRSPGAFFDEMKHPNDTKIYSARIIPLRGSWLEFVTdindvmyfyIDRRK-------------KFPVTTLLRAIGYSTD 215
Cdd:PRK08565   156 EDLAPNRVLVDKGEAGSSITHTAKVISSRAGYRAQVT---------VERRKdgtiyvsfpavpgKIPFVILMRALGLETD 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  216 REIyelfdmVEEVGVDDKkiesyfgktvlmdvidyetgeillekdstLDQESLANLrahhiEKVKfvksespyspeiinn 295
Cdd:PRK08565   227 RDI------VYAVSLDPE-----------------------------IQQELLPSL-----EQAS--------------- 251
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  296 tirkDPTKSEKEALEMIYRHLRSGDAPD--LETARNLVFRFFFnPKrydlgevgryrlnnkLGLSidpdvtvltKEDIIA 373
Cdd:PRK08565   252 ----SIAATVEDALDYIGKRVAIGQPREyrIERAEQILDKYLL-PH---------------LGTS---------PEDRIK 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  374 -------IINYLLDLRNGKIQADDIDHLGNRRIKTVGEQLAAQMSVGLSRLARTVK----------ERMNLRDneeLTPQ 436
Cdd:PRK08565   303 kayflgqMASKLLELYLGRREPDDKDHYANKRLRLAGDLLAELFRVAFKQLVKDLKyqleksyargRKLDLRA---IVRP 379
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  437 DLVNARTI--LSVINTFFGTSQLSQFMDQTNPLAEMTHKRRLsaLGPggLTRERAGFEVRDVHYTHYGRLCPIETPEGPN 514
Cdd:PRK08565   380 DIITERIRhaLATGNWVGGRTGVSQLLDRTNYLSTLSHLRRV--VSP--LSRGQPHFEARDLHGTQWGRICPFETPEGPN 455
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  515 IGLISSLTTF----------------------------------------------------------------GRIN-- 528
Cdd:PRK08565   456 CGLVKNLALMaqisvgvdeeeveeilyelgvvpveeareeeyiswsrvylngrligyhpdgeelaekirelrrsGKISde 535
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  529 -KLGFIETPYRKVV-----DGRV--------------TDE--------------------IHYLSADDEENLRVAQAnaP 568
Cdd:PRK08565   536 vNVAYIETGEINEVyvncdSGRVrrplivvengkpklTREhveklkkgeltfddlvkmgvIEYLDAEEEENAYVALD--P 613
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  569 IDekgnfindrvqvrfrgdfplVTPKEVdYMDVSPTQMVSAAASLIPFLEHDDANRALMGSNMQRQSVPLlkPEApivgt 648
Cdd:PRK08565   614 ED--------------------LTPEHT-HLEIWPPAILGITASIIPYPEHNQSPRNTYQAAMAKQSLGL--YAA----- 665
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  649 gvEAKVALDSRAMIVcrrsgvvervdatkivvraddldadaelnveslldfdsdetdVYPlqkfkrsnqdtctnQIPLVR 728
Cdd:PRK08565   666 --NFRIRTDTRGHLL------------------------------------------HYP--------------QRPLVQ 687
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  729 egdrvqkgdvladgcaTEGGEL------ALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIHIEVLETQVRDTKRG 802
Cdd:PRK08565   688 ----------------TRALEIigyndrPAGQNAVVAVLSYTGYNIEDAIIMNKASIERGLARSTFFRTYETEERKYPGG 751
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  803 EEElTREIP--NVS----EEATKDLDENGIIRVGAEVHEGDILVGKVTPkgetdP--TPEEKLLKAIFGEKagdvKDASL 874
Cdd:PRK08565   752 QED-KIEIPepNVRgyrgEEYYRKLDEDGIVSPEVEVKGGDVLIGKTSP-----PrfLEELEELSLGLQER----RDTSV 821
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  875 KAPTGLHGTViatklfsrkkrdaknkrlekkelekvekwytaekqrikrlrdkklRRVLLDQKSagiselDGGKVVvrak 954
Cdd:PRK08565   822 TVRHGEKGIV---------------------------------------------DTVLITESP------EGNKLV---- 846
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  955 tvlkkdllenldfdaldltrplvddaernelvaeileqyykkldslqedyenqkfKVTVGDELPPgivqmakvyvakkrk 1034
Cdd:PRK08565   847 -------------------------------------------------------KVRVRDLRIP--------------- 856
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1035 lMIGDKMAGRHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWA----GKILDvmySTPvFDG 1110
Cdd:PRK08565   857 -ELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVaaleGRFVD---ATP-FYG 931
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1111 ASLEEVQTEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQPLGGKAQFGGQR 1190
Cdd:PRK08565   932 EPEEELRKELLKLGYKPDGTEVMYDGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLR 1011
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1191 FGEMEVWALEAYGAAHTLQEILTVKSD----------------DVrgRSKAYEAIVKGES--LPDPGVPESFNVLIRELM 1252
Cdd:PRK08565  1012 FGEMERDCLIGHGAAMLLKERLLDSSDkttiyvcelcghiawyDR--RKNKYVCPIHGDKgnISPVEVSYAFKLLLQELM 1089
                         1450
                   ....*....|....
gi 1176173580 1253 GLGLDVELLnLKDE 1266
Cdd:PRK08565  1090 SMGISPRLK-LGDK 1102
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
549-1265 1.57e-65

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 233.77  E-value: 1.57e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  549 IHYLSADDEENLRVAQanapiDEKGnfindrvqvrfrgdfplVTPKEVdYMDVSPTQMVSAAASLIPFLEHDDANRALMG 628
Cdd:TIGR03670   92 IEYLDAEEEENAYIAL-----DPEE-----------------LTPEHT-HLEIDPSAILGIIASTIPYPEHNQSPRNTMG 148
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  629 SNMQRQSVPLlkPEAPIvgtgveaKVALDSRAmivcrrsgvvervdatkivvraddldadaelnveSLLDfdsdetdvYP 708
Cdd:TIGR03670  149 AAMAKQSLGL--YAANY-------RIRLDTRG----------------------------------HLLH--------YP 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  709 lqkfkrsnqdtctnQIPLVREgdRVQKgdvladgcATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIH 788
Cdd:TIGR03670  178 --------------QKPLVKT--RVLE--------LIGYDDRPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTF 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  789 IEVLETQVRDTKRGEEELTrEIPNV------SEEATKDLDENGIIRVGAEVHEGDILVGKVTPkgetdPTPEEKLlkAIF 862
Cdd:TIGR03670  234 FRTYEAEERRYPGGQEDRF-EIPEPdvrgyrGEEAYKHLDEDGIVYPEVEVKGGDVLIGKTSP-----PRFLEEL--REF 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  863 GEKAGDVKDASLKAPTGLHGTViatklfsrkkrdaknkrlekkelekvekwytaekqrikrlrDKklrrvlldqksagis 942
Cdd:TIGR03670  306 GLVTERRRDTSVTVRHGEKGIV-----------------------------------------DK--------------- 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  943 eldggkvVVRAKTVlkkdllenldfdaldltrplvddaERNELVaeileqyykkldslqedyenqkfKVTVGDELPPgiv 1022
Cdd:TIGR03670  330 -------VIITETE------------------------EGNKLV-----------------------KVRVRDLRIP--- 352
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1023 qmakvyvakkrklMIGDKMAGRHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWA----GKI 1098
Cdd:TIGR03670  353 -------------ELGDKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEMIAGKVaaleGRR 419
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1099 LDvmySTPvFDGASLEEVQTEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLITQQ 1178
Cdd:TIGR03670  420 VD---GTP-FEGEPEEELRKELLKLGFKPDGKEVMYDGITGEKLEAEIFIGVIYYQKLHHMVADKIHARSRGPVQVLTRQ 495
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1179 PLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDV---------------RGRSKAYEAIVKGESLPDP-GVPE 1242
Cdd:TIGR03670  496 PTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESDKYvvyvcencghiawedKRKGTAYCPVCGETGDISPvEMSY 575
                          730       740
                   ....*....|....*....|...
gi 1176173580 1243 SFNVLIRELMGLGLDVElLNLKD 1265
Cdd:TIGR03670  576 AFKLLLDELKSLGISPR-LELGD 597
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
549-1265 1.52e-57

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 210.59  E-value: 1.52e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  549 IHYLSADDEENLRVAQANAPIDEKGnfindrvqvrfrgdfplvTPKEVDymdvsPTQMVSAAASLIPFLEHDDANRALMG 628
Cdd:PRK07225    98 IEYLDAEEEENAYIAVYEEDLTEEH------------------THLEID-----PSLILGIGAGMIPYPEHNASPRITMG 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  629 SNMQRQSVPLlkPEAPIvgtgveaKVALDSRAmivcrrsgvvervdatkivvraddldadaelnveSLLDfdsdetdvYP 708
Cdd:PRK07225   155 AGMIKQSLGL--PAANY-------KLRPDTRG----------------------------------HLLH--------YP 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  709 lqkfkrsnqdtctnQIPLVREgdRVQKgdvladgcATEGGELALGRNVLVAFMPWRGYNFEDAIVISERVVQEDVYTSIH 788
Cdd:PRK07225   184 --------------QVPLVKT--QTQE--------IIGFDERPAGQNFVVAVMSYEGYNIEDALIMNKASIERGLGRSHF 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  789 IEVLETQVRDTKRGEEElTREIPNV------SEEATKDLDENGIIRVGAEVHEGDILVGKVTPkgetdptP---EEKllk 859
Cdd:PRK07225   240 FRTYEGEERRYPGGQED-RFEIPDKdvrgyrGEEAYRHLDEDGLVNPETEVKEGDVLIGKTSP-------PrflEEP--- 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  860 AIFGEKAGDVKDASLKAPTGLHGTViatklfsrkkrDAknkrlekkelekvekwytaekqrikrlrdkklrrVLLDQKSa 939
Cdd:PRK07225   309 DDFGISPEKRRETSVTMRSGEEGIV-----------DT----------------------------------VILTETE- 342
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  940 giselDGGKVVvraktvlkkdllenldfdaldltrplvddaernelvaeileqyykkldslqedyenqkfKVTVGDELPP 1019
Cdd:PRK07225   343 -----EGSRLV-----------------------------------------------------------KVRVRDLRIP 358
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1020 givqmakvyvakkrklMIGDKMAGRHGNKGVVATIVPVEDMPFLPDGTPVDIVLNPLGVPSRMNLGQIMETSLGWA---- 1095
Cdd:PRK07225   359 ----------------ELGDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLEMIGGKVgsle 422
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1096 GKILDvmySTPvFDGASLEEVQTEMEEAGLPRDGKSILFDGRTGEQFDNPVTIGFIYIMKLSHLVEDKIHARSIGPYSLI 1175
Cdd:PRK07225   423 GRRVD---GTA-FSGEDEEDLREALEKLGFEHTGKEVMYDGITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVL 498
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1176 TQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDV---------------RGRSKAYEAIVKGES-LPDPG 1239
Cdd:PRK07225   499 TRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESDKVeiyvcakcgmiaiydKKRNRKYCPICGEETdIYPVE 578
                          730       740
                   ....*....|....*....|....*.
gi 1176173580 1240 VPESFNVLIRELMGLGLDVElLNLKD 1265
Cdd:PRK07225   579 MSYAFKLLLDELKSLGIAPR-LELED 603
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
23-444 2.75e-57

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 203.77  E-value: 2.75e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   23 LLNIQLESFKEFVQPDVPPEKRENKGLQAVFNSIFPIEDSrENFVLDFISYYLEKPKYSVD----------ECQERGNTY 92
Cdd:pfam04563    2 LVRQQLDSFNEFVDNDLQKIIDENALIESEFEIQHPGENG-DKLSLKFGQIRLGKPMFDETdgstreiypqECRLRNLTY 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   93 AAPLKAKLRLSIRDPEsdsgeiiDSMEQTVYLGNIPMMTEK------------------------GTFIINGAERIVVSQ 148
Cdd:pfam04563   81 SAPLYVDLELSVYNGE-------DIKPIEVFIGRLPIMLRSnacilsgateselvklgecpldpgGYFIINGSEKVIVAQ 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  149 LHRS---PGAFFDemKHPNDT----KIYSARII---PLRGSWLEFV-TDINDVMYFYIDRRKK-FPVTTLLRAIGYSTDR 216
Cdd:pfam04563  154 EHRSrnhPIVFKK--ADPKKRgsvaSVRSSAEIsvrPDSTSWVNVLeYLSNGTIYFKFPYIKKeIPIVIILRALGFTSDR 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  217 EIYELfdmveevgvddkkiesyfgktVLMDVIDYETGEILLEkdsTLDQEslANLRAHHIEKVKfvksespyspEIINNT 296
Cdd:pfam04563  232 EIFEL---------------------ICYDVNDQQLQEELLP---SLEEG--FKIRIQTQEQAL----------DYIGGR 275
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  297 IRKdptksekealemIYRHLRSGDAPDLETARNLVFRFFFNPKRYDLGEVGRYRLnnklglsidpdvtvltkedIIAIIN 376
Cdd:pfam04563  276 GRA------------IFRMGRPREPRIKYAEEILQKEVLPHLGTYELDETKKAYF-------------------IGYMIR 324
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  377 YLLDLRNGKIQADDIDHLGNRRIKTVGEQLAAQMSVGLSRLARTVKERMN--LRDNEELTPQDLVNARTI 444
Cdd:pfam04563  325 RLLLLALGRREVDDRDHLGNKRLRLAGPLLASLFRVLFKKLVRDVRERLQkvLGSPDDLMLQLLVNAKPI 394
RNA_pol_Rpb2_45 pfam10385
RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent ...
537-602 3.58e-37

RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region.


Pssm-ID: 463067 [Multi-domain]  Cd Length: 66  Bit Score: 133.64  E-value: 3.58e-37
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176173580  537 YRKVVDGRVTDEIHYLSADDEENLRVAQANAPIDEKGNFINDRVQVRFRGDFPLVTPKEVDYMDVS 602
Cdd:pfam10385    1 YRKVEDGKVTDEIVYLTADEEDGYVIAQANAPLDEDGRFVDERVSARYRGEFPLVPPEEVDYMDVS 66
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
459-524 2.93e-34

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 125.72  E-value: 2.93e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176173580  459 QFMDQTNPLAEMTHKRRLSAlGPGGLTRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLTTF 524
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNS-PRGGLFREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALY 65
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
1187-1261 1.37e-33

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 124.24  E-value: 1.37e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580 1187 GGQRFGEMEVWALEAYGAAHTLQEILTVKSD----DVRGRSKAYEA-----IVKGESLPDPG-VPESFNVLIRELMGLGL 1256
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDayevDVCGRCGLYAAynkcpICKGETDISPGyIPESFKLLFQELQSLGI 80

                   ....*
gi 1176173580 1257 DVELL 1261
Cdd:pfam04560   81 DPRLL 85
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
27-522 3.06e-31

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 129.68  E-value: 3.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   27 QLESFKEFVqpdvppekreNKGLQAVFNSIFPIE-DSRENFVLDFISYYLEKP----------KYSVDECQERGNTYAAP 95
Cdd:PRK09606    22 HIDSYNDFV----------DNGLQKIIDEQGPIEtEIEDGVYVELGKIRVGKPvvkeadgserEIYPMEARLRNLTYSAP 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580   96 LKAKLRLSIRDPESDSGEiidsmeqtVYLGNIPMM-----------TEK-------------GTFIINGAERIVVSQLHR 151
Cdd:PRK09606    92 LYLEMSPVEGGEEEEPEE--------VYIGELPVMvgskicnlyglSEEelievgedpldpgGYFIVNGSERVLMTLEDL 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  152 SPGAFFDEMKHPNDTKIYSARIIPLRGSWLEFVT-DINDVMYFYID---RRKKFPVTTLLRAIGYSTDREIyelfdmVEE 227
Cdd:PRK09606   164 APNKILVEKDERYGDRIEVAKVFSQRRGYRALVTvERNRDGLLEVSfpsVPGSIPFVILMRALGLETDEEI------VEA 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  228 VGVDDkkiesyfgktvlmdvidyETGEILLEkdstldqeslaNLRAHHIEkvkfvksespyspeiinntirkdptkSEKE 307
Cdd:PRK09606   238 VSDDP------------------EIVKFMLE-----------NLEEAEVD--------------------------TQEE 262
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  308 ALEMIYRHLRSGDAPDLETARnlvfrfffnpkrydlgevGRYRLNNKLGLSIDPDvtvltKEDIIAIINYL-------LD 380
Cdd:PRK09606   263 ALEYIGKRVAPGQTKEYRIKR------------------AEYVIDRYLLPHLGVE-----PEVRRAKAHYLgrmaeacFE 319
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  381 LRNGKIQADDIDHLGNRRIKTVGEQLAAQMSVGLSRLARTVK---ERMNLRdNEELTPQDLVNA-------RTILSVINT 450
Cdd:PRK09606   320 LALGRREEDDKDHYANKRLKLAGDLMEDLFRVAFNRLARDVKyqlERANMR-NRELSIKTAVRSdvlterlEHAMATGNW 398
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176173580  451 FFGTSQLSQFMDQTNPLAEMTHKRRLSAlgpgGLTRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLT 522
Cdd:PRK09606   399 VGGRTGVSQLLDRTDYMATLSHLRRVVS----PLSRSQPHFEARDLHPTQWGRICPSETPEGPNCGLVKNFA 466
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
151-400 2.16e-22

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 95.88  E-value: 2.16e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  151 RSPGAFFDEMKHPND-TKIYSARIIPLRGSWLEFVTDINDVMYFYIDRRKKFPVTTLLRAIGYSTDREIYELfdmVEEVG 229
Cdd:pfam04561    1 RSNGIYVEKELDKNGiIATYTSSLISNRGSWLKLEIDGKTLIWSRPSKKRKIPIVIFLKALGLVSDREILDR---LCYDF 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  230 VDDKKIESYFGKTvlmdvidyetgeillekdstldqeslanLRAHHIEkvkfvksespyspeiinntirkdptkSEKEAL 309
Cdd:pfam04561   78 NDPQMLELLKPEL----------------------------EEAENIY--------------------------TQEEAL 103
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173580  310 EMIYRH--LRSGDAPDLETARNlVFRFFFNpkrydlgevgRYRLNNKLGLSIDPDVTVLTKEDIIAIINYLLDLRNGKIQ 387
Cdd:pfam04561  104 DYIGKGfaLRRGEEPRLQRARE-ILYSRDP----------KYNLNKHLGLNEPFENERLKAQDILYMIDRLLNLKLGRRK 172
                          250
                   ....*....|...
gi 1176173580  388 ADDIDHLGNRRIK 400
Cdd:pfam04561  173 PDDIDHLGNKRVR 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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