NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|11761629|ref|NP_068657|]
View 

fibrinogen alpha chain isoform alpha precursor [Homo sapiens]

Protein Classification

Fib_alpha and Fibrinogen_aC domain-containing protein( domain architecture ID 10554886)

protein containing domains Fib_alpha, Fibrinogen_aC, and PI3K_1B_p101

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 49-191 3.01e-63

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


:

Pssm-ID: 462570  Cd Length: 143  Bit Score: 205.47  E-value: 3.01e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629    49 DSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYN 128
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11761629   129 RVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALARE 191
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
Fibrinogen_aC pfam12160
Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 ...
 445-509 8.86e-23

Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with pfam08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.


:

Pssm-ID: 432370  Cd Length: 68  Bit Score: 92.21  E-value: 8.86e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11761629   445 GKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLG---TLSGIGTLDGF 509
Cdd:pfam12160   1 GKEKVTSGGTTTTRRSCSKTITKTVIGPDGRKEVTKEVVTSEDGSDCGDATDLDtfhTFSGRGSLDEF 68
PI3K_1B_p101 super family cl11126
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
 465-644 1.18e-04

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


The actual alignment was detected with superfamily member pfam10486:

Pssm-ID: 463109  Cd Length: 860  Bit Score: 45.45  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629   465 VTKTVIGPDGH--KEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRhpdeAAFFDTAS---TGKTF--PGFFSPML 537
Cdd:pfam10486 296 VLNEILLKESDldSPVDSEDEEEEDEVDFDEEEDLEEDDELPERDSLAHR----ASTFSTASsssTDSMFstLSLSSSSL 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629   538 GEFVSETESrGSESGIFTNTKESSShhpgiaEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTH 617
Cdd:pfam10486 372 TPSVSSLSS-GVDSDYCEDSDESSS------SSPRAEKPREKSKKKSRSRLSQRIYRLFKPKSPLVLRRAKSLGNPEAKD 444

                         170       180       190
                  ....*....|....*....|....*....|.
gi 11761629   618 ST----KRGHAKSRPVRGIHTSPLGKPSLSP 644
Cdd:pfam10486 445 LIpvrsKRSNSLPQQVLLRSLEPPPLPPLSA 475
 
Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 49-191 3.01e-63

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 205.47  E-value: 3.01e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629    49 DSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYN 128
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11761629   129 RVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALARE 191
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
Fibrinogen_aC pfam12160
Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 ...
 445-509 8.86e-23

Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with pfam08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.


Pssm-ID: 432370  Cd Length: 68  Bit Score: 92.21  E-value: 8.86e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11761629   445 GKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLG---TLSGIGTLDGF 509
Cdd:pfam12160   1 GKEKVTSGGTTTTRRSCSKTITKTVIGPDGRKEVTKEVVTSEDGSDCGDATDLDtfhTFSGRGSLDEF 68
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
 465-644 1.18e-04

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 463109  Cd Length: 860  Bit Score: 45.45  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629   465 VTKTVIGPDGH--KEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRhpdeAAFFDTAS---TGKTF--PGFFSPML 537
Cdd:pfam10486 296 VLNEILLKESDldSPVDSEDEEEEDEVDFDEEEDLEEDDELPERDSLAHR----ASTFSTASsssTDSMFstLSLSSSSL 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629   538 GEFVSETESrGSESGIFTNTKESSShhpgiaEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTH 617
Cdd:pfam10486 372 TPSVSSLSS-GVDSDYCEDSDESSS------SSPRAEKPREKSKKKSRSRLSQRIYRLFKPKSPLVLRRAKSLGNPEAKD 444

                         170       180       190
                  ....*....|....*....|....*....|.
gi 11761629   618 ST----KRGHAKSRPVRGIHTSPLGKPSLSP 644
Cdd:pfam10486 445 LIpvrsKRSNSLPQQVLLRSLEPPPLPPLSA 475
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 522-627 9.80e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 39.22  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629   522 TASTGKTFPgfFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEfpSRGKSSSYSKQFTSSTSYNRGDSTFESKSY 601
Cdd:NF033849  256 SHSVGTSES--HSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSS--SVGTSESQSHGTTEGTSTTDSSSHSQSSSY 331

                          90       100
                  ....*....|....*....|....*...
gi 11761629   602 KMADEAGSEADH--EGTHSTKRGHAKSR 627
Cdd:NF033849  332 NVSSGTGVSSSHsdGTSQSTSISHSESS 359
 
Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 49-191 3.01e-63

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 205.47  E-value: 3.01e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629    49 DSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYN 128
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11761629   129 RVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALARE 191
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
Fibrinogen_aC pfam12160
Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 ...
 445-509 8.86e-23

Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with pfam08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.


Pssm-ID: 432370  Cd Length: 68  Bit Score: 92.21  E-value: 8.86e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11761629   445 GKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLG---TLSGIGTLDGF 509
Cdd:pfam12160   1 GKEKVTSGGTTTTRRSCSKTITKTVIGPDGRKEVTKEVVTSEDGSDCGDATDLDtfhTFSGRGSLDEF 68
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
 465-644 1.18e-04

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 463109  Cd Length: 860  Bit Score: 45.45  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629   465 VTKTVIGPDGH--KEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRhpdeAAFFDTAS---TGKTF--PGFFSPML 537
Cdd:pfam10486 296 VLNEILLKESDldSPVDSEDEEEEDEVDFDEEEDLEEDDELPERDSLAHR----ASTFSTASsssTDSMFstLSLSSSSL 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629   538 GEFVSETESrGSESGIFTNTKESSShhpgiaEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTH 617
Cdd:pfam10486 372 TPSVSSLSS-GVDSDYCEDSDESSS------SSPRAEKPREKSKKKSRSRLSQRIYRLFKPKSPLVLRRAKSLGNPEAKD 444

                         170       180       190
                  ....*....|....*....|....*....|.
gi 11761629   618 ST----KRGHAKSRPVRGIHTSPLGKPSLSP 644
Cdd:pfam10486 445 LIpvrsKRSNSLPQQVLLRSLEPPPLPPLSA 475
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 522-627 9.80e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 39.22  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11761629   522 TASTGKTFPgfFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEfpSRGKSSSYSKQFTSSTSYNRGDSTFESKSY 601
Cdd:NF033849  256 SHSVGTSES--HSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSS--SVGTSESQSHGTTEGTSTTDSSSHSQSSSY 331

                          90       100
                  ....*....|....*....|....*...
gi 11761629   602 KMADEAGSEADH--EGTHSTKRGHAKSR 627
Cdd:NF033849  332 NVSSGTGVSSSHsdGTSQSTSISHSESS 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH