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Conserved domains on  [gi|1176161353|gb|OQX77728|]
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histidine kinase [Epsilonproteobacteria bacterium 4484_65]

Protein Classification

HAMP domain-containing histidine kinase( domain architecture ID 17609529)

two-component sensor histidine kinase with a HAMP signaling domain, similar to RstB, which functions as a membrane-associated protein kinase that phosphorylates RstA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsS_fam_HK super family cl45818
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ...
 5-396 1.00e-137

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.


The actual alignment was detected with superfamily member NF038389:

Pssm-ID: 468500 [Multi-domain]  Cd Length: 402  Bit Score: 398.83  E-value: 1.00e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353   5 TSLRSKINLVFSIILLLLAILFTVSIKYDHAKFEEHTAAQERVMSHYLYMYYLKHG--EIDQAYLDAQNISLITDKGKKV 82
Cdd:NF038389    1 HSIFFKITILFAIALVSVSALFLILLKYQKENYNEELNKKYSLIANTLLQLYQKNIneEELEKYLKNFGFMPITDKKLEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353  83 QIERYFKDKGKLKRY---AVDTYHLKRIIIINNDRFKLILENKNKMQYPLKRVMVF-TIVFLLIILLYLWIIKSLKPLSE 158
Cdd:NF038389   81 EILEIGKNKFILKENgsfRILKYNDKIYLLIKNDGFSLLLEDNEKKSYRYYYIIVFfIFLILLLLILYISVLKSLKPLKK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 159 LKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLHDEKNKARM 238
Cdd:NF038389  161 LKKQIKKFANGDFDFIKSESNGDEIGEVANEFDKAVKKIKALNESRQLFLRNIMHELKTPITKGRIVAEMLEDEKQKERL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 239 HSIFERLNLLIDEFAKIEKITSKNFELTIKPYKMSDLLEASIDMLMIEnPKHLITTEIKEDYILDVDFELFTLVIKNLLD 318
Cdd:NF038389  241 ISIFERLESLINEFAKIEQLTSKNYKLNKKEYRLSDIIDEAIDMLMID-DSSVIIKVSLEDFKLNVDFELFSLAIKNLID 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 319 NGIKYSIDKHITVVIDENRLEIINRGEALTEPLENYFKPFH----TSKKGLGLGLYIVKSILDIHQMELGYQHEESKNIF 394
Cdd:NF038389  320 NAIKYSPDKKVTIEIKGDKIEFKNKGEPLEEPLEYYFEPFFkgneKSKSGFGLGLYIVKNILKAHGFKLEYEYENGYNIF 399


                  ..
gi 1176161353 395 TV 396
Cdd:NF038389  400 II 401
 
Name Accession Description Interval E-value
ArsS_fam_HK NF038389
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ...
 5-396 1.00e-137

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.


Pssm-ID: 468500 [Multi-domain]  Cd Length: 402  Bit Score: 398.83  E-value: 1.00e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353   5 TSLRSKINLVFSIILLLLAILFTVSIKYDHAKFEEHTAAQERVMSHYLYMYYLKHG--EIDQAYLDAQNISLITDKGKKV 82
Cdd:NF038389    1 HSIFFKITILFAIALVSVSALFLILLKYQKENYNEELNKKYSLIANTLLQLYQKNIneEELEKYLKNFGFMPITDKKLEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353  83 QIERYFKDKGKLKRY---AVDTYHLKRIIIINNDRFKLILENKNKMQYPLKRVMVF-TIVFLLIILLYLWIIKSLKPLSE 158
Cdd:NF038389   81 EILEIGKNKFILKENgsfRILKYNDKIYLLIKNDGFSLLLEDNEKKSYRYYYIIVFfIFLILLLLILYISVLKSLKPLKK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 159 LKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLHDEKNKARM 238
Cdd:NF038389  161 LKKQIKKFANGDFDFIKSESNGDEIGEVANEFDKAVKKIKALNESRQLFLRNIMHELKTPITKGRIVAEMLEDEKQKERL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 239 HSIFERLNLLIDEFAKIEKITSKNFELTIKPYKMSDLLEASIDMLMIEnPKHLITTEIKEDYILDVDFELFTLVIKNLLD 318
Cdd:NF038389  241 ISIFERLESLINEFAKIEQLTSKNYKLNKKEYRLSDIIDEAIDMLMID-DSSVIIKVSLEDFKLNVDFELFSLAIKNLID 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 319 NGIKYSIDKHITVVIDENRLEIINRGEALTEPLENYFKPFH----TSKKGLGLGLYIVKSILDIHQMELGYQHEESKNIF 394
Cdd:NF038389  320 NAIKYSPDKKVTIEIKGDKIEFKNKGEPLEEPLEYYFEPFFkgneKSKSGFGLGLYIVKNILKAHGFKLEYEYENGYNIF 399


                  ..
gi 1176161353 395 TV 396
Cdd:NF038389  400 II 401
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
189-396 3.94e-32

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 121.55  E-value: 3.94e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 189 EFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLHDEKNK---------ARMHSIFERLNLLIDEFAKIEKIT 259
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLspeerrellEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 260 SKNFELTIKPYKMSDLLEASIDMLMIENPKHLITTEIK---EDYILDVDFELFTLVIKNLLDNGIKYSIDK-HITVVIDE 335
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDlppELPLVYADPELLEQVLANLLDNAIKYSPPGgTITISARR 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176161353 336 N----RLEIINRGEALTEP-LENYFKPFHT-----SKKGLGLGLYIVKSILDIHQMELGYQHEESK-NIFTV 396
Cdd:COG2205   161 EgdgvRISVSDNGPGIPEEeLERIFERFYRgdnsrGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTV 232
PRK10337 PRK10337
sensor protein QseC; Provisional
 197-389 1.22e-13

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 71.99  E-value: 1.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 197 IRELLQS-RQLFLR--AIM-----------HELKTPIAKGRL---VSEMLHD-----EKNKARMHSIFERLNLLIDEFAK 254
Cdd:PRK10337  216 VRPLVEAlNQLFARthAMMvrerrftsdaaHELRSPLAALKVqteVAQLSDDdpqarKKALLQLHAGIDRATRLVDQLLT 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 255 IEKITSKNFELTIKPYKMSDLLE-ASIDMLM------IENPKHLITTEIkedyILDVDFELFTLVIKNLLDNGIKYS-ID 326
Cdd:PRK10337  296 LSRLDSLDNLQDVAEIPLEDLLQsAVMDIYHtaqqagIDVRLTLNAHPV----IRTGQPLLLSLLVRNLLDNAIRYSpQG 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161353 327 KHITVVIDENRLEIINRG-----EALTEPLENYFKPFHTSKKGLGLGLYIVKSILDIHQMELGYQHEE 389
Cdd:PRK10337  372 SVVDVTLNARNFTVRDNGpgvtpEALARIGERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAP 439
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 305-396 1.54e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 60.84  E-value: 1.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 305 DFELFTLVIKNLLDNGIKYS-IDKHITVVI---DENRLEIINRGEALT-EPLENYFKPFHTSKK----GLGLGLYIVKSI 375
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAaKAGEITVTLsegGELTLTVEDNGIGIPpEDLPRIFEPFSTADKrgggGTGLGLSIVRKL 81

                          90       100
                  ....*....|....*....|..
gi 1176161353 376 LDIHQMELGYQHEESKN-IFTV 396
Cdd:pfam02518  82 VELLGGTITVESEPGGGtTVTL 103
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 305-396 3.29e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 59.97  E-value: 3.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353  305 DFELFTLVIKNLLDNGIKYSIDK-HITVVI----DENRLEIINRGEALTEP-LENYFKPFHTSKK------GLGLGLYIV 372
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGgRITVTLerdgDHVEITVEDNGPGIPPEdLEKIFEPFFRTDKrsrkigGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*
gi 1176161353  373 KSILDIHQMELGYQHEESKN-IFTV 396
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGtTFTI 106
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 152-396 4.11e-10

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 61.25  E-value: 4.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 152 SLKPLSELKDKIQTFSQGNLDIECK-SNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAkgrlvSEMLH 230
Cdd:TIGR01386 188 GLEPLRRLSAVAARISPESLDQRLDpSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLT-----NLLGQ 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 231 DEKNKARMHSIFERLNLL---IDEFAKIEKITS-----------------KNFELTIKPYKMSDLLEASIDmlmienpKH 290
Cdd:TIGR01386 263 TQVALSQPRTGEEYREVLesnLEELERLSRMVSdmlflaradngqlalerVRLDLAAELAKVAEYFEPLAE-------ER 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 291 LITTEIKEDYILDVDFELFTLVIKNLLDNGIKYSID-KHITVVI----DENRLEIINRGEAL-TEPLENYFKPF------ 358
Cdd:TIGR01386 336 GVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDgGTITVRIerrsDEVRVSVSNPGPGIpPEHLSRLFDRFyrvdpa 415

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1176161353 359 -HTSKKGLGLGLYIVKSILDIHQMELGYQHEESKNIFTV 396
Cdd:TIGR01386 416 rSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFIL 454
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-396 1.25e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 46.61  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 312 VIKNLLDNGIKYSIDK---HITVVIDEN--RLEIINRGEA-LTEPLENYFKPFH---TSKK--GLGLGLYIVKSILDIHQ 380
Cdd:cd16923     4 VFSNLLSNAIKYSPENtriYITSFLTDDvvNIMFKNPSSHpLDFKLEKLFERFYrgdNSRNteGAGLGLSIAKAIIELHG 83

                          90
                  ....*....|....*.
gi 1176161353 381 MELGYQHEESKNIFTV 396
Cdd:cd16923    84 GSASAEYDDNHDLFKV 99
 
Name Accession Description Interval E-value
ArsS_fam_HK NF038389
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ...
 5-396 1.00e-137

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.


Pssm-ID: 468500 [Multi-domain]  Cd Length: 402  Bit Score: 398.83  E-value: 1.00e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353   5 TSLRSKINLVFSIILLLLAILFTVSIKYDHAKFEEHTAAQERVMSHYLYMYYLKHG--EIDQAYLDAQNISLITDKGKKV 82
Cdd:NF038389    1 HSIFFKITILFAIALVSVSALFLILLKYQKENYNEELNKKYSLIANTLLQLYQKNIneEELEKYLKNFGFMPITDKKLEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353  83 QIERYFKDKGKLKRY---AVDTYHLKRIIIINNDRFKLILENKNKMQYPLKRVMVF-TIVFLLIILLYLWIIKSLKPLSE 158
Cdd:NF038389   81 EILEIGKNKFILKENgsfRILKYNDKIYLLIKNDGFSLLLEDNEKKSYRYYYIIVFfIFLILLLLILYISVLKSLKPLKK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 159 LKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLHDEKNKARM 238
Cdd:NF038389  161 LKKQIKKFANGDFDFIKSESNGDEIGEVANEFDKAVKKIKALNESRQLFLRNIMHELKTPITKGRIVAEMLEDEKQKERL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 239 HSIFERLNLLIDEFAKIEKITSKNFELTIKPYKMSDLLEASIDMLMIEnPKHLITTEIKEDYILDVDFELFTLVIKNLLD 318
Cdd:NF038389  241 ISIFERLESLINEFAKIEQLTSKNYKLNKKEYRLSDIIDEAIDMLMID-DSSVIIKVSLEDFKLNVDFELFSLAIKNLID 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 319 NGIKYSIDKHITVVIDENRLEIINRGEALTEPLENYFKPFH----TSKKGLGLGLYIVKSILDIHQMELGYQHEESKNIF 394
Cdd:NF038389  320 NAIKYSPDKKVTIEIKGDKIEFKNKGEPLEEPLEYYFEPFFkgneKSKSGFGLGLYIVKNILKAHGFKLEYEYENGYNIF 399


                  ..
gi 1176161353 395 TV 396
Cdd:NF038389  400 II 401
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
189-396 3.94e-32

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 121.55  E-value: 3.94e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 189 EFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLHDEKNK---------ARMHSIFERLNLLIDEFAKIEKIT 259
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLspeerrellEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 260 SKNFELTIKPYKMSDLLEASIDMLMIENPKHLITTEIK---EDYILDVDFELFTLVIKNLLDNGIKYSIDK-HITVVIDE 335
Cdd:COG2205    81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDlppELPLVYADPELLEQVLANLLDNAIKYSPPGgTITISARR 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176161353 336 N----RLEIINRGEALTEP-LENYFKPFHT-----SKKGLGLGLYIVKSILDIHQMELGYQHEESK-NIFTV 396
Cdd:COG2205   161 EgdgvRISVSDNGPGIPEEeLERIFERFYRgdnsrGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTV 232
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
191-396 5.71e-30

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 119.27  E-value: 5.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 191 DHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLHDEKNK---------ARMHSIFERLNLLIDEFAKIEKITSK 261
Cdd:COG5002   152 ERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADdpeerreylEIILEEAERLSRLVNDLLDLSRLESG 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 262 NFELTIKPYKMSDLLEASIDMLMIENPKHLITTEIK---EDYILDVDFELFTLVIKNLLDNGIKYS-IDKHITVVIDEN- 336
Cdd:COG5002   232 ELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDlpeDPLLVLGDPDRLEQVLTNLLDNAIKYTpEGGTITVSLREEd 311

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176161353 337 ---RLEIINRGEALT-EPLENYFKPFHTSKK-------GLGLGLYIVKSILDIHQMELGYQHEESK-NIFTV 396
Cdd:COG5002   312 dqvRISVRDTGIGIPeEDLPRIFERFYRVDKsrsretgGTGLGLAIVKHIVEAHGGRIWVESEPGKgTTFTI 383
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
181-396 9.72e-28

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 111.54  E-value: 9.72e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 181 DEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLHDEKNK------ARMHSIFERLNLLIDEFAK 254
Cdd:COG0642    87 LLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEeqreylETILRSADRLLRLINDLLD 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 255 IEKITSKNFELTIKPYKMSDLLEASIDML--MIENPKHLITTEIKED-YILDVDFELFTLVIKNLLDNGIKYS-IDKHIT 330
Cdd:COG0642   167 LSRLEAGKLELEPEPVDLAELLEEVVELFrpLAEEKGIELELDLPDDlPTVRGDPDRLRQVLLNLLSNAIKYTpEGGTVT 246

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176161353 331 VVIDEN----RLEIINRGEALT-EPLENYFKPFHTSK-----KGLGLGLYIVKSILDIHQMELGYQHEESKN-IFTV 396
Cdd:COG0642   247 VSVRREgdrvRISVEDTGPGIPpEDLERIFEPFFRTDpsrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKGtTFTV 323
PRK10337 PRK10337
sensor protein QseC; Provisional
 197-389 1.22e-13

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 71.99  E-value: 1.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 197 IRELLQS-RQLFLR--AIM-----------HELKTPIAKGRL---VSEMLHD-----EKNKARMHSIFERLNLLIDEFAK 254
Cdd:PRK10337  216 VRPLVEAlNQLFARthAMMvrerrftsdaaHELRSPLAALKVqteVAQLSDDdpqarKKALLQLHAGIDRATRLVDQLLT 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 255 IEKITSKNFELTIKPYKMSDLLE-ASIDMLM------IENPKHLITTEIkedyILDVDFELFTLVIKNLLDNGIKYS-ID 326
Cdd:PRK10337  296 LSRLDSLDNLQDVAEIPLEDLLQsAVMDIYHtaqqagIDVRLTLNAHPV----IRTGQPLLLSLLVRNLLDNAIRYSpQG 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161353 327 KHITVVIDENRLEIINRG-----EALTEPLENYFKPFHTSKKGLGLGLYIVKSILDIHQMELGYQHEE 389
Cdd:PRK10337  372 SVVDVTLNARNFTVRDNGpgvtpEALARIGERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAP 439
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 197-380 1.08e-11

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 65.75  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 197 IRELLQSRQL-----FLRAIMHELKTPIAKGRLVSEMLHD--EKNKARMHSIF-----------ERLNLLIDEFAKIeki 258
Cdd:COG5000   189 ITELLRAERLaawgeLARRIAHEIKNPLTPIQLSAERLRRklADKLEEDREDLeraldtiirqvDRLKRIVDEFLDF--- 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 259 tSKNFELTIKPYKMSDLLEASIDMLMIENPKHLITTEI---KEDYILDVDFELFTLVIKNLLDNGIkYSIDKHITVVI-- 333
Cdd:COG5000   266 -ARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELdldPDLPEVLADRDQLEQVLINLLKNAI-EAIEEGGEIEVst 343

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1176161353 334 ----DENRLEIINRGEALT-EPLENYFKPFHTSK-KGLGLGLYIVKSILDIHQ 380
Cdd:COG5000   344 rredGRVRIEVSDNGPGIPeEVLERIFEPFFTTKpKGTGLGLAIVKKIVEEHG 396
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 305-396 1.54e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 60.84  E-value: 1.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 305 DFELFTLVIKNLLDNGIKYS-IDKHITVVI---DENRLEIINRGEALT-EPLENYFKPFHTSKK----GLGLGLYIVKSI 375
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAaKAGEITVTLsegGELTLTVEDNGIGIPpEDLPRIFEPFSTADKrgggGTGLGLSIVRKL 81

                          90       100
                  ....*....|....*....|..
gi 1176161353 376 LDIHQMELGYQHEESKN-IFTV 396
Cdd:pfam02518  82 VELLGGTITVESEPGGGtTVTL 103
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 305-396 3.29e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 59.97  E-value: 3.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353  305 DFELFTLVIKNLLDNGIKYSIDK-HITVVI----DENRLEIINRGEALTEP-LENYFKPFHTSKK------GLGLGLYIV 372
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGgRITVTLerdgDHVEITVEDNGPGIPPEdLEKIFEPFFRTDKrsrkigGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*
gi 1176161353  373 KSILDIHQMELGYQHEESKN-IFTV 396
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGtTFTI 106
PRK10604 PRK10604
sensor protein RstB; Provisional
 154-380 6.67e-11

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 63.47  E-value: 6.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 154 KPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLHD-- 231
Cdd:PRK10604  162 QDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNls 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 232 EKNKARMHSIFERLNLLIDEFAKIEKITSKNFELTIKPYKMSDLLEASI-DMLMIENPKHL-ITTEIKEDYILdVDFELF 309
Cdd:PRK10604  242 AAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLaDIQAVTPEKTVrLDTPHQGDYGA-LDMRLM 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 310 TLVIKNLLDNGIKYSIDK-HITVVIDENR--LEIINRGEAL-TEPLENYFKPF-------HTSKKGLGLGLYIVKSILDI 378
Cdd:PRK10604  321 ERVLDNLLNNALRYAHSRvRVSLLLDGNQacLIVEDDGPGIpPEERERVFEPFvrldpsrDRATGGCGLGLAIVHSIALA 400


                  ..
gi 1176161353 379 HQ 380
Cdd:PRK10604  401 MG 402
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
154-383 2.44e-10

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 61.52  E-value: 2.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 154 KPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLhdEK 233
Cdd:PRK10755   87 RPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELL--EK 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 234 NK--------AR----MHSIfERLNLLidefAKIEKitsknfELTIKPYKMSDLLEASIDMLMIE-------NPKHLITT 294
Cdd:PRK10755  165 QHhidvapliARldqmMHTV-EQLLQL----ARAGQ------SFSSGHYQTVKLLEDVILPSQDElsemleqRQQTLLLP 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 295 EIKEDYILDVDFELFTLVIKNLLDNGIKYSID-KHITVVIDEN----RLEIINRG--------EALTEPlenyFKPFHTS 361
Cdd:PRK10755  234 ESAADITVQGDATLLRLLLRNLVENAHRYSPEgSTITIKLSQEdggaVLAVEDEGpgideskcGELSKA----FVRMDSR 309

                         250       260
                  ....*....|....*....|..
gi 1176161353 362 KKGLGLGLYIVKSILDIHQMEL 383
Cdd:PRK10755  310 YGGIGLGLSIVSRITQLHHGQF 331
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 152-396 4.11e-10

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 61.25  E-value: 4.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 152 SLKPLSELKDKIQTFSQGNLDIECK-SNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAkgrlvSEMLH 230
Cdd:TIGR01386 188 GLEPLRRLSAVAARISPESLDQRLDpSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLT-----NLLGQ 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 231 DEKNKARMHSIFERLNLL---IDEFAKIEKITS-----------------KNFELTIKPYKMSDLLEASIDmlmienpKH 290
Cdd:TIGR01386 263 TQVALSQPRTGEEYREVLesnLEELERLSRMVSdmlflaradngqlalerVRLDLAAELAKVAEYFEPLAE-------ER 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 291 LITTEIKEDYILDVDFELFTLVIKNLLDNGIKYSID-KHITVVI----DENRLEIINRGEAL-TEPLENYFKPF------ 358
Cdd:TIGR01386 336 GVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDgGTITVRIerrsDEVRVSVSNPGPGIpPEHLSRLFDRFyrvdpa 415

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1176161353 359 -HTSKKGLGLGLYIVKSILDIHQMELGYQHEESKNIFTV 396
Cdd:TIGR01386 416 rSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFIL 454
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 180-380 8.69e-10

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 59.81  E-value: 8.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 180 QDEIAEVANEFDHAVTMIRELLQSRQLFLRA------------IMHELKTPIAKGRLVSEMLHDE-KNKARMHSIFERLN 246
Cdd:COG4191   106 NAELEELERDITELERAEEELRELQEQLVQSeklaalgelaagIAHEINNPLAAILGNAELLRRRlEDEPDPEELREALE 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 247 LLIDEFAKIEKITS--KNF----ELTIKPYKMSDLLEASIDMLMIENPKHLITTEIK---EDYILDVDFELFTLVIKNLL 317
Cdd:COG4191   186 RILEGAERAAEIVRslRAFsrrdEEEREPVDLNELIDEALELLRPRLKARGIEVELDlppDLPPVLGDPGQLEQVLLNLL 265

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176161353 318 DNGIkYSIDK------HITVVIDEN--RLEIINRGEALTEP-LENYFKPFHTSK---KGLGLGLYIVKSILDIHQ 380
Cdd:COG4191   266 INAI-DAMEEgeggriTISTRREGDyvVISVRDNGPGIPPEvLERIFEPFFTTKpvgKGTGLGLSISYGIVEKHG 339
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
154-380 1.28e-09

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 59.56  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 154 KPLSELKDKIQTFSQGNLDI--ECKSNNQdEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEML-- 229
Cdd:PRK09470  192 KPARKLKNAADEVAQGNLRQhpELETGPQ-EFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLrr 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 230 -HDEKNK-ARMHSIFERLNLLIDEFAKIEKITSKNfELTIKPYKMSDLLEASIDMLMIE---NPKHLITTEIKEDYILDV 304
Cdd:PRK09470  271 rQGESKElERIETEAQRLDSMINDLLVLSRNQQKN-HLERETFKANSLWSEVLEDAKFEaeqMGKSLTVSAPPGPWPING 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 305 DFELFTLVIKNLLDNGIKYSiDKHITVVI--DENRLEII--NRGEALTEP-LENYFKPFH-------TSKKGLGLGLYIV 372
Cdd:PRK09470  350 NPNALASALENIVRNALRYS-HTKIEVAFsvDKDGLTITvdDDGPGVPEEeREQIFRPFYrvdeardRESGGTGLGLAIV 428


                  ....*...
gi 1176161353 373 KSILDIHQ 380
Cdd:PRK09470  429 ENAIQQHR 436
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 197-379 1.37e-09

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 59.80  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 197 IRELLQS-RQL--FLRAIMHELKTPIAK----GRLVSEMLH---DEKNK---ARMHSIFERLNLLID---EFAKIEKIts 260
Cdd:COG4251   272 TAELERSnEELeqFAYVASHDLREPLRKisgfSQLLEEDYGdklDEEGReylERIRDAAERMQALIDdllAYSRVGRQ-- 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 261 knfELTIKPYKMSDLLEASIDMLMIENPKHLITTEIKEDYILDVDFELFTLVIKNLLDNGIKYSIDK-----HITVVIDE 335
Cdd:COG4251   350 ---ELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGeppriEIGAEREG 426

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1176161353 336 NRLEI--------INRGEAlteplENYFKPF---HTSKK--GLGLGLYIVKSILDIH 379
Cdd:COG4251   427 GEWVFsvrdngigIDPEYA-----EKIFEIFqrlHSRDEyeGTGIGLAIVKKIVERH 478
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 181-383 7.38e-09

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 57.16  E-value: 7.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 181 DEIAEVANEFDHavtMiRELLQSRQL---FLRAIMHELKTPIAKGRLVSEMLHDEKNKARM----HSIFE---RLNLLID 250
Cdd:PRK11100  234 SELRELAQALES---M-RVKLEGKAYveqYVQTLTHELKSPLAAIRGAAELLQEDPPPEDRarftGNILTqsaRLQQLID 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 251 ---EFAKIEkitSKNFELTIKPYKMSDLLEASIDMLMIENPKHLITTEIK-EDYILDVDFELFTLVIKNLLDNGIKYS-- 324
Cdd:PRK11100  310 rllELARLE---QRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRpDDARVLGDPFLLRQALGNLLDNAIDFSpe 386

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176161353 325 ---IDKHITVVIDENRLEIINRGEALTEP-LENYFKPF------HTSKKGLGLGLYIVKSILDIHQMEL 383
Cdd:PRK11100  387 ggtITLSAEVDGEQVALSVEDQGPGIPDYaLPRIFERFyslprpANGRKSTGLGLAFVREVARLHGGEV 455
envZ PRK09467
osmolarity sensor protein; Provisional
 182-380 3.02e-08

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 55.30  E-value: 3.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 182 EIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLHDEKN--KARMHSIFERLNLLIDEFakIEKIT 259
Cdd:PRK09467  207 EVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMSEEDGylAESINKDIEECNAIIEQF--IDYLR 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 260 SKNfELTIKPYKMSDLLEasiDMLMIENP-KHLITTEIKeDYILDVDFELFTL--VIKNLLDNGIKYSIDK-HITVVIDE 335
Cdd:PRK09467  285 TGQ-EMPMEMADLNALLG---EVIAAESGyEREIETALQ-PGPIEVPMNPIAIkrALANLVVNAARYGNGWiKVSSGTEG 359

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1176161353 336 NRLEII--NRGEAL-TEPLENYFKPF-----HTSKKGLGLGLYIVKSILDIHQ 380
Cdd:PRK09467  360 KRAWFQveDDGPGIpPEQLKHLFQPFtrgdsARGSSGTGLGLAIVKRIVDQHN 412
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
153-379 7.49e-08

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 54.25  E-value: 7.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 153 LKPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIA--KGRLvsEMLH 230
Cdd:PRK10549  189 LAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAvlRGEL--EAIQ 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 231 DEKNKARMHSIferlNLLIDEFAKIEKITSKNFELTI----------KPYKMSDLLEASIDML--MIENPKHLITTEIKE 298
Cdd:PRK10549  267 DGVRKFTPESV----ASLQAEVGTLTKLVDDLHQLSLsdegalayrkTPVDLVPLLEVAGGAFreRFASRGLTLQLSLPD 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 299 DYIL--DVD--FELFTlvikNLLDNGIKYSIDK---HITVVIDENRLEIINRGEA---LTEPLENYFKPFHTSKK----- 363
Cdd:PRK10549  343 SATVfgDPDrlMQLFN----NLLENSLRYTDSGgslHISAEQRDKTLRLTFADSApgvSDEQLQKLFERFYRTEGsrnra 418

                         250
                  ....*....|....*...
gi 1176161353 364 --GLGLGLYIVKSILDIH 379
Cdd:PRK10549  419 sgGSGLGLAICLNIVEAH 436
PRK10490 PRK10490
sensor protein KdpD; Provisional
 198-379 9.85e-08

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 54.27  E-value: 9.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 198 REllQSRQLFLRAIMHELKTPIAKGRLVSEML----------HDEK-NKARMHSI-FERL--NLLidEFAKIEkitSKNF 263
Cdd:PRK10490  660 RE--QLRNALLAALSHDLRTPLTVLFGQAEILtldlasegspHARQaSEIRQQVLnTTRLvnNLL--DMARIQ---SGGF 732

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 264 ELTIKPYKMSDLLEASIDMLMIENPKHLITTEIKEDYIL-DVDFELFTLVIKNLLDNGIKYSIDKH---ITVVIDENRLE 339
Cdd:PRK10490  733 NLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLiHVDGPLFERVLINLLENAVKYAGAQAeigIDAHVEGERLQ 812

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1176161353 340 II--NRGEALTEPLENY-FKPFHTSKK-----GLGLGLYIVKSILDIH 379
Cdd:PRK10490  813 LDvwDNGPGIPPGQEQLiFDKFARGNKesaipGVGLGLAICRAIVEVH 860
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 153-383 4.60e-07

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 52.00  E-value: 4.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 153 LKPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDH----AVTMIRELLQ------SRQLFLRAIM---------- 212
Cdd:COG4192   352 VKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLRVfrdqAIEKTQELETeieerkRIEKNLRQTQdeliqaakma 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 213 ----------HELKTPIAKGRLVSEMLH---DEKNKARMHSIFERLNLLIDEFAKIEK---ITSKNFELTIKPYKMSDLL 276
Cdd:COG4192   432 vvgqtmtslaHELNQPLNAMSMYLFSAKkalEQENYAQLPTSLDKIEGLIERMDKIIKslrQFSRKSDTPLQPVDLRQVI 511

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 277 EASIDMLMIENPKHLITTEIKEDYILDVDFELFTLVIKNLLDNGIKYSID-KHITVVIDEN----RLEIINRGE--ALTE 349
Cdd:COG4192   512 EQAWELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATqPQISVDLLSNaenlRVAISDNGNgwPLVD 591

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1176161353 350 PLenyFKPFHTSKK-GLGLGLYIVKSILDIHQMEL 383
Cdd:COG4192   592 KL---FTPFTTTKEvGLGLGLSICRSIMQQFGGDL 623
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
198-380 8.49e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 50.62  E-value: 8.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 198 RELLQSRQL-----FLRAIMHELKTPIA--KG--RLVSEMLHDEKNKARMHSIFE---RLNLLIDEFakieKITSKNFEL 265
Cdd:COG3852   124 RELRRAEKLaavgeLAAGLAHEIRNPLTgiRGaaQLLERELPDDELREYTQLIIEeadRLNNLVDRL----LSFSRPRPP 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 266 TIKPYKMSDLLEASIDMLMIENPKHLittEIKEDY---ILDV--DFELFTLVIKNLLDNG-----------IKYSIDKHI 329
Cdd:COG3852   200 EREPVNLHEVLERVLELLRAEAPKNI---RIVRDYdpsLPEVlgDPDQLIQVLLNLVRNAaeampeggtitIRTRVERQV 276

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 330 TVVIDENR----LEIINRG----EALtepLENYFKPFHTSK-KGLGLGLYIVKSILDIHQ 380
Cdd:COG3852   277 TLGGLRPRlyvrIEVIDNGpgipEEI---LDRIFEPFFTTKeKGTGLGLAIVQKIVEQHG 333
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-396 1.25e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 46.61  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 312 VIKNLLDNGIKYSIDK---HITVVIDEN--RLEIINRGEA-LTEPLENYFKPFH---TSKK--GLGLGLYIVKSILDIHQ 380
Cdd:cd16923     4 VFSNLLSNAIKYSPENtriYITSFLTDDvvNIMFKNPSSHpLDFKLEKLFERFYrgdNSRNteGAGLGLSIAKAIIELHG 83

                          90
                  ....*....|....*.
gi 1176161353 381 MELGYQHEESKNIFTV 396
Cdd:cd16923    84 GSASAEYDDNHDLFKV 99
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
203-396 1.42e-06

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 50.50  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353  203 SRQLFLRAIMHELKTPIAKGRLVSEMLHDE--KNKARMHSIF------ERLNLLIDEFAKIEKITSKNFELTIKPYKMSD 274
Cdd:PRK09959   711 AKSQFLATMSHEIRTPISSIMGFLELLSGSglSKEQRVEAISlayatgQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353  275 LLEASIDML-MIENPKHL---ITTEIKEDYILDVDFELFTLVIKNLLDNGIKYSIDKHITVV-----IDEN----RLEII 341
Cdd:PRK09959   791 LVQNTCHSFgAIAASKSIalsCSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITtslghIDDNhaviKMTIM 870

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176161353  342 NRGEALT-EPLENYFKPFHTS-----KKGLGLGLYIVKSILDIHQMELGYQ-HEESKNIFTV 396
Cdd:PRK09959   871 DSGSGLSqEEQQQLFKRYSQTsagrqQTGSGLGLMICKELIKNMQGDLSLEsHPGIGTTFTI 932
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 308-393 1.43e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 46.63  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 308 LFTLVIKNLLDNGIKYSIDKHITVVIDENR----LEIINRG-----EALTEPLENYFKPFHTSKKGLGLGLYIVKSILDI 378
Cdd:cd16940    13 LLFLLLRNLVDNAVRYSPQGSRVEIKLSADdgavIRVEDNGpgideEELEALFERFYRSDGQNYGGSGLGLSIVKRIVEL 92

                          90
                  ....*....|....*
gi 1176161353 379 HQMELGYQHEESKNI 393
Cdd:cd16940    93 HGGQIFLGNAQGGGL 107
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 180-396 1.36e-05

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 46.77  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 180 QDEIAEVANEFDHAVTMIRELlqsrqlflRAIMHELKTpiakgRL--VSEMLHDEKNKarmhsifERLNLLIDEFAKIEK 257
Cdd:COG3290   173 RTELERLEEELEGVKELAEAL--------RAQRHDFRN-----HLhtISGLLQLGEYD-------EALEYIDEISEELQE 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 258 ITSKNFELTIKPY-------KMSDLLEASIDMLMIENpkhlitTEIKEDYILDVDFelfTLVIKNLLDNGIKY-----SI 325
Cdd:COG3290   233 LIDSLLSRIGNPVlaalllgKAARARERGIDLTIDID------SDLPDLPLSDTDL---VTILGNLLDNAIEAveklpEE 303

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176161353 326 DKHITVVI----DENRLEIINRGEALT-EPLENYFKPFHTSKKGL--GLGLYIVKSILDIHQMELGYQHEESKN-IFTV 396
Cdd:COG3290   304 ERRVELSIrddgDELVIEVEDSGPGIPeELLEKIFERGFSTKLGEgrGLGLALVKQIVEKYGGTIEVESEEGEGtVFTV 382
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 312-396 2.60e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 42.87  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 312 VIKNLLDNGIKYSIDKHITVVIdeNRLEIINRGEALT------------EPLENYFKPFH-----TSKK--GLGLGLYIV 372
Cdd:cd16922     4 ILLNLLGNAIKFTEEGEVTLRV--SLEEEEEDGVQLRfsvedtgigipeEQQARLFEPFSqadssTTRKygGTGLGLAIS 81

                          90       100
                  ....*....|....*....|....*
gi 1176161353 373 KSILDIHQMELGYQHEESK-NIFTV 396
Cdd:cd16922    82 KKLVELMGGDISVESEPGQgSTFTF 106
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
153-202 3.05e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 41.08  E-value: 3.05e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1176161353  153 LKPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRELLQ 202
Cdd:smart00304   4 LRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
154-380 3.92e-05

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 45.53  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 154 KPLSELKDKIQTFSQGNLDIECKSNNQD-EIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELKTPIAKGRLVSEMLhde 232
Cdd:PRK09835  211 APIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIA--- 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 233 KNKARMHSIFERL---NLliDEFAKIEKITS-----------------KNFELTIKPYKMSDLLEASID----MLMIENP 288
Cdd:PRK09835  288 LSQSRSQKELEDVlysNL--EELTRMAKMVSdmlflaqadnnqlipekKMLDLADEVGKVFDFFEAWAEergvELRFVGD 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 289 KHLITTeikedyildvDFELFTLVIKNLLDNGIKYSIDKH-ITVVIDEN----RLEIINRGEALT-EPLENYFKPFHT-- 360
Cdd:PRK09835  366 PCQVAG----------DPLMLRRAISNLLSNALRYTPAGEaITVRCQEVdhqvQLVVENPGTPIApEHLPRLFDRFYRvd 435

                         250       260
                  ....*....|....*....|....*
gi 1176161353 361 -----SKKGLGLGLYIVKSILDIHQ 380
Cdd:PRK09835  436 psrqrKGEGSGIGLAIVKSIVVAHK 460
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
153-203 5.26e-05

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 45.40  E-value: 5.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1176161353 153 LKPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRELLQS 203
Cdd:COG0840   207 TRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQ 257
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 211-380 5.96e-05

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 45.11  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 211 IMHELKTPIA--KGRLvsEMLHDEKNKARmhsifERLNLLIDEFAKIEKITS------KNFELTIKPYKMSDLLEASIdM 282
Cdd:COG5805   294 IAHEIRNPLTsiKGFL--QLLQPGIEDKE-----EYFDIMLSELDRIESIISeflalaKPQAVNKEKENINELIQDVV-T 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 283 LM----IENPKHLITTEIKEDYILDVDFELFTLVIKNLLDNGIKY-----SIDKHITVVIDENRLEIINRGEAL-TEPLE 352
Cdd:COG5805   366 LLeteaILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAmpnggTITIHTEEEDNSVIIRVIDEGIGIpEERLK 445

                         170       180
                  ....*....|....*....|....*....
gi 1176161353 353 NYFKPFHTSK-KGLGLGLYIVKSILDIHQ 380
Cdd:COG5805   446 KLGEPFFTTKeKGTGLGLMVSYKIIENHN 474
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-383 6.03e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 42.00  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 312 VIKNLLDNGIKYSIDKH-------ITVVIDENR---LEIINRGEALTEPL-ENYFKPFHTSKK-GLGLGLYIVKSILDIH 379
Cdd:cd16920     4 VLINLVRNGIEAMSEGGcerreltIRTSPADDRavtISVKDTGPGIAEEVaGQLFDPFYTTKSeGLGMGLSICRSIIEAH 83


                  ....
gi 1176161353 380 QMEL 383
Cdd:cd16920    84 GGRL 87
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 211-380 6.88e-05

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 44.97  E-value: 6.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 211 IMHELKTPIA--KG--RLVSEMLHDEKNK--ARMHSIFERLNLLIDEFAKIEKITSKNFEltikPYKMSDLLEASIDMLM 284
Cdd:COG5809   277 IAHEIRNPLTslKGfiQLLKDTIDEEQKTylDIMLSELDRIESIISEFLVLAKPQAIKYE----PKDLNTLIEEVIPLLQ 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 285 IE-NPKHL-ITTEIkEDYILDV--DFELFTLVIKNLLDNGIKySIDKHITVVIDENRLE-------IINRGEALTEP-LE 352
Cdd:COG5809   353 PQaLLKNVqIELEL-EDDIPDIlgDENQLKQVFINLLKNAIE-AMPEGGNITIETKAEDddkvvisVTDEGCGIPEErLK 430

                         170       180
                  ....*....|....*....|....*....
gi 1176161353 353 NYFKPFHTSK-KGLGLGLYIVKSILDIHQ 380
Cdd:COG5809   431 KLGEPFYTTKeKGTGLGLMVSYKIIEEHG 459
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
304-380 7.24e-05

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 44.96  E-value: 7.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 304 VDFELFTLVIKNLLDNG-------------IKYSIDKHITVVIDENRLEIINrgealtEPLENYFKPFHTSK-KGLGLGL 369
Cdd:PRK11360  496 ADPELLKQVLLNILINAvqaisargkirirTWQYSDGQVAVSIEDNGCGIDP------ELLKKIFDPFFTTKaKGTGLGL 569

                          90
                  ....*....|.
gi 1176161353 370 YIVKSILDIHQ 380
Cdd:PRK11360  570 ALSQRIINAHG 580
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
153-347 1.37e-04

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 43.95  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 153 LKPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMHELktpiakgRLVSEMLHDE 232
Cdd:COG2770   237 TRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAEL-------ARLLEALLEL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 233 KNKARMHSIFERLNLLIDEFAKIEKITSKNFELTIKPYKMSDLLEASIDMLMIENPKHLITTEIKEDYILDVDFELFTLV 312
Cdd:COG2770   310 LLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELA 389

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1176161353 313 IKNLLDNGIKYSIDKHITVVIDENRLEIINRGEAL 347
Cdd:COG2770   390 AVLALLAALAAALLLLELALEELVLALLALALLAL 424
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 313-383 1.43e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 40.91  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 313 IKNLLDNGIKYSIDKHITVVI-----DENRLEIINRGEALTE-PLENYFKPF------HTSKKGLGLGLYIVKSILDIHQ 380
Cdd:cd16945     9 INNLLDNAIDFSPEGGLIALQleadtEGIELLVFDEGSGIPDyALNRVFERFyslprpHSGQKSTGLGLAFVQEVAQLHG 88


                  ...
gi 1176161353 381 MEL 383
Cdd:cd16945    89 GRI 91
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 203-256 1.87e-04

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 39.50  E-value: 1.87e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176161353 203 SRQLFLRAIMHELKTPIAKGRLVSEMLHDEKNKARMHSIFE-------RLNLLID---EFAKIE 256
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLEtilrsaeRLLRLINdllDLSRIE 64
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-380 3.43e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 39.74  E-value: 3.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161353 312 VIKNLLDNGIKY---SIDKHITVVIDENRLEIINRGEALT-EPLENYFKPFHTSKK-----GLGLGLYIVKSILDIHQ 380
Cdd:cd16950     4 VLSNLVDNALRYgggWVEVSSDGEGNRTRIQVLDNGPGIApEEVDELFQPFYRGDNargtsGTGLGLAIVQRISDAHG 81
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 153-200 4.06e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 37.81  E-value: 4.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1176161353 153 LKPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHavtMIREL 200
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQ---MAERL 45
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 274-387 4.06e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 40.31  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 274 DLLEASIDML-MIENPKHL-ITTEIKEDYILDVDFELFTLVIKNLLDNGIKYSI----------DKHITVVIDEN----- 336
Cdd:cd16954     1 PLLDSLCSALnKVYQRKGVsISLDISPELRFPGERNDLMELLGNLLDNACKWCLefvevtarqtDGGLHLIVDDDgpgvp 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1176161353 337 ---RLEIINRGEALTEplenyfkpfhtSKKGLGLGLYIVKSILDIHQMELGYQH 387
Cdd:cd16954    81 esqRSKIFQRGQRLDE-----------QRPGQGLGLAIAKEIVEQYGGELSLSD 123
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 201-252 6.30e-04

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 37.96  E-value: 6.30e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 201 LQSRQLFLRAIMHELKTPIAKGRLVSEMLHDEKNK--------ARMHSIFERLNLLIDEF 252
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDdeeqreylERIREEAERLLRLINDL 60
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
154-379 8.06e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 41.54  E-value: 8.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 154 KPLSELKDKIQTFSQGNLdIECKSNNQDEIAEVANEFDHAVTMIRELLQSRQLFLRAIMH-ELKTpiakgrlvsemlhde 232
Cdd:COG2972   183 RPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEaELKA--------------- 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 233 kNKARM--HSIFERLNlLIDEFAKIEkitsknfeltiKPYKMSDLLEASIDML--MIENPKHLIT--TEIK--EDYI--- 301
Cdd:COG2972   247 -LQAQInpHFLFNTLN-SIRWLAELE-----------DPEEAEEMLEALSKLLrySLSKGDELVTleEELEliKSYLeiq 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 302 -------LDVDFE---------LFTLVIKNLLDNGIKYSIDK-------HITVVIDENRL--EIINRGEALT-EPLENYF 355
Cdd:COG2972   314 klrfgdrLEVEIEideelldllIPKLILQPLVENAIEHGIEPkegggtiRISIRKEGDRLviTVEDNGVGMPeEKLEKLL 393

                         250       260
                  ....*....|....*....|....
gi 1176161353 356 KPFHTSKKGLGLGLYIVKSILDIH 379
Cdd:COG2972   394 EELSSKGEGRGIGLRNVRERLKLY 417
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
307-396 1.63e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 38.36  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 307 ELFTlvikNLLDNGIKYSIDKHITVV--IDENRLEII--NRGEALtePLENYFKPFHTSKKGlGLGLYIVKSILDihqmE 382
Cdd:COG2172    41 EAVT----NAVRHAYGGDPDGPVEVEleLDPDGLEIEvrDEGPGF--DPEDLPDPYSTLAEG-GRGLFLIRRLMD----E 109

                          90
                  ....*....|....
gi 1176161353 383 LGYQHEESKNIFTV 396
Cdd:COG2172   110 VEYESDPGGTTVRL 123
HAMP pfam00672
HAMP domain;
153-199 1.70e-03

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 36.06  E-value: 1.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1176161353 153 LKPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIRE 199
Cdd:pfam00672   7 LRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 153-347 1.96e-03

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 40.25  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 153 LKPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHavtMIRElLQSRQLFLRAIMHELKTpiakgrlvSEMLHDE 232
Cdd:COG3850   143 VRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNR---MADE-LQELYAELEEEEELEAE--------LELLALL 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 233 KNKARMHSIFERLNLLIDEFAKIEKITSKNFELTIKPYKMSDLLEASIDMLMIENPKHLITTEIKEDYILDVDFELFTLV 312
Cdd:COG3850   211 DELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLL 290

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1176161353 313 IKNLLDNGIKYSIDKHITVVIDENRLEIINRGEAL 347
Cdd:COG3850   291 ELVELLALAAAEEALLLLVELAALLLLLLLQAIAN 325
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 305-383 2.63e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 37.06  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 305 DFELFTLVIKNLLDNGIKYSIDK---HITVVIDENRL--EIINRGEALTEP-LENYFKPFHT------SKKGLGLGLYIV 372
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGgtvSISIYDEEEYLyfEIWDNGHGFSEQdLKKALELFYRddtsrrSGGHYGMGLYIA 80

                          90
                  ....*....|.
gi 1176161353 373 KSILDIHQMEL 383
Cdd:cd16975    81 KNLVEKHGGSL 91
PRK09303 PRK09303
histidine kinase;
198-333 2.81e-03

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 39.55  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 198 RELLQSRQLFLRAIMHELKTPIAKGRLVSEML----HDEKNKARMHSI----------FERLNLLIDEFakIEKITSKNF 263
Cdd:PRK09303  145 LEQLKFKDRVLAMLAHDLRTPLTAASLALETLelgqIDEDTELKPALIeqlqdqarrqLEEIERLITDL--LEVGRTRWE 222

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176161353 264 ELTIKPYKM--SDLLEASIDML--MIENPKHLITTEIKEDY-ILDVDFELFTLVIKNLLDNGIKYSIDK-HITVVI 333
Cdd:PRK09303  223 ALRFNPQKLdlGSLCQEVILELekRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGgTITLSM 298
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 321-379 3.06e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 37.13  E-value: 3.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176161353 321 IKYSIDKHITVVIDenrleIINRGEAL-TEPLENYFKPFHTSK-KGLGLGLYIVKSILDIH 379
Cdd:cd16944    32 IRVEADQDGRIVLI-----VCDNGKGFpREMRHRATEPYVTTRpKGTGLGLAIVKKIMEEH 87
PRK15347 PRK15347
two component system sensor kinase;
154-375 4.26e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 39.24  E-value: 4.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 154 KPLSELKDKIQTFSQGNLDIECKSNNQDEIAEVANEFDHAVTMIR---------------ELLQSRQLFLRA-------- 210
Cdd:PRK15347  323 KPLWRFVDIINKTGPAALEPRLPENRLDELGSIAKAYNQLLDTLNeqydtlenkvaertqALAEAKQRAEQAnkrksehl 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 211 --IMHELKTPI--AKGRLvsEMLHDEKNKARMH-----------SIFERLNLLIDeFAKIEkitSKNFELTIKPYKMSDL 275
Cdd:PRK15347  403 ttISHEIRTPLngVLGAL--ELLQNTPLTAEQMdladtarqctlSLLAIINNLLD-FSRIE---SGQMTLSLEETALLPL 476

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161353 276 LEASidMLMIENPKH--------LITTEIKEDYILDvdfelfTLVIK----NLLDNGIKYSIDKHI--TVVIDENRL--E 339
Cdd:PRK15347  477 LDQA--MLTIQGPAQsksltlrtFVGAHVPLYLHLD------SLRLRqilvNLLGNAVKFTETGGIrlRVKRHEQQLcfT 548

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1176161353 340 IINRGEALTEPLEN-YFKPFH---TSKKGLGLGLYIVKSI 375
Cdd:PRK15347  549 VEDTGCGIDIQQQQqIFTPFYqadTHSQGTGLGLTIASSL 588
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 203-256 4.54e-03

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 35.23  E-value: 4.54e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176161353  203 SRQLFLRAIMHELKTPIAKGRLVSEML-------HDEKNKARMHSIFERLNLLID---EFAKIE 256
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLldtelseEQREYLETILREAERLLRLINdllDLSRIE 64
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-377 5.75e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 36.11  E-value: 5.75e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161353 312 VIKNLLDNGIKYSIDK-HITVVIDEN----RLEIINRGEAL-TEPLENYFKPFHTSKKG------LGLGLYIVKSILD 377
Cdd:cd16948     9 IIGQIVSNALKYSKQGgKIEIYSETNeqgvVLSIKDFGIGIpEEDLPRVFDKGFTGENGrnfqesTGMGLYLVKKLCD 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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