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Conserved domains on  [gi|1176161350|gb|OQX77725|]
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hypothetical protein B6D54_01280, partial [Epsilonproteobacteria bacterium 4484_65]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 1562436)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 8-184 4.25e-47

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


:

Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 159.98  E-value: 4.25e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   8 DQIKAYVDTK--QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTaFDVELASQAEELAKKVGMTLELGNYVDSI 85
Cdd:COG0446   113 DALREALKEFkgKRAVVIGGGPIGLELAEALRKRGLKVTLVERAPRLLGV-LDPEMAALLEEELREHGVELRLGETVVAI 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  86 KEENGIvtGVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRDFITREPS 165
Cdd:COG0446   192 DGDDKV--AVTLTDGEEIPADLVVVAPGVRPNTELAKDAGLALGERGWIKVDETLQTSDPDVYAAGDCAEVPHPVTGKTV 269

                         170
                  ....*....|....*....
gi 1176161350 166 KVMLASTSVAEARAAGSSL 184
Cdd:COG0446   270 YIPLASAANKQGRVAAENI 288
Pyr_redox_dim super family cl38095
Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both ...
 199-276 1.80e-09

Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.


The actual alignment was detected with superfamily member pfam02852:

Pssm-ID: 427019 [Multi-domain]  Cd Length: 109  Bit Score: 54.10  E-value: 1.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 199 IFSTVIMERAFASAGVTEVQAKMQNLDIVTGT--FEGMNRhpATIPDAVKQSVKLIAMNHSGRIIGGQIVgGPEVGELIS 276
Cdd:pfam02852   1 IPSVVFTDPEIASVGLTEEEAKEKGGEVKVGKfpFAANGR--ALAYGDTDGFVKLVADRETGKILGAHIV-GPNAGELIQ 77
 
Name Accession Description Interval E-value
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 8-184 4.25e-47

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 159.98  E-value: 4.25e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   8 DQIKAYVDTK--QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTaFDVELASQAEELAKKVGMTLELGNYVDSI 85
Cdd:COG0446   113 DALREALKEFkgKRAVVIGGGPIGLELAEALRKRGLKVTLVERAPRLLGV-LDPEMAALLEEELREHGVELRLGETVVAI 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  86 KEENGIvtGVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRDFITREPS 165
Cdd:COG0446   192 DGDDKV--AVTLTDGEEIPADLVVVAPGVRPNTELAKDAGLALGERGWIKVDETLQTSDPDVYAAGDCAEVPHPVTGKTV 269

                         170
                  ....*....|....*....
gi 1176161350 166 KVMLASTSVAEARAAGSSL 184
Cdd:COG0446   270 YIPLASAANKQGRVAAENI 288
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 17-267 3.02e-45

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 158.28  E-value: 3.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  17 KQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDVELASQAEELAKKVGMTLELGNYVDSIKEENGiVTGVE 96
Cdd:PRK09564  149 IKNIVIIGAGFIGLEAVEAAKHLGKNVRIIQLEDRILPDSFDKEITDVMEEELRENGVELHLNEFVKSLIGEDK-VEGVV 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  97 LCGGKvIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRDFITREPSKVMLASTSVAE 176
Cdd:PRK09564  228 TDKGE-YEADVVIVATGVKPNTEFLEDTGLKTLKNGAIIVDEYGETSIENIYAAGDCATIYNIVSNKNVYVPLATTANKL 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 177 ARAAGSSLY-KIKYIKGFNGTIAIfstVIMERAFASAGVTEVQAKMQNLDIVTGTFEGMNrHPATIPDAVKQSVKLIAMN 255
Cdd:PRK09564  307 GRMVGENLAgRHVSFKGTLGSACI---KVLDLEAARTGLTEEEAKKLGIDYKTVFIKDKN-HTNYYPGQEDLYVKLIYEA 382

                         250
                  ....*....|..
gi 1176161350 256 HSGRIIGGQIVG 267
Cdd:PRK09564  383 DTKVILGGQIIG 394
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 13-177 2.15e-33

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 123.58  E-value: 2.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  13 YVDTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNtAFDVELASQAEELAKKVGMTLELGNYVDSIKEENGIV 92
Cdd:pfam07992 148 LKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEALDRLLR-AFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGDGV 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  93 TgVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRdfitrepskVMLAST 172
Cdd:pfam07992 227 E-VILKDGTEIDADLVVVAIGRRPNTELLEAAGLELDERGGIVVDEYLRTSVPGIYAAGDCRVGG---------PELAQN 296


                  ....*
gi 1176161350 173 SVAEA 177
Cdd:pfam07992 297 AVAQG 301
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 8-157 3.45e-18

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 84.49  E-value: 3.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   8 DQIKAYVDTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDVELASQAEELAKKVGMTLELGNYVDSIKE 87
Cdd:TIGR02374 131 DAIMAMAQRFKKAAVIGGGLLGLEAAVGLQNLGMDVSVIHHAPGLMAKQLDQTAGRLLQRELEQKGLTFLLEKDTVEIVG 210

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  88 EnGIVTGVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARygGIWVDEYMRTRDHDIFAVGDCAARR 157
Cdd:TIGR02374 211 A-TKADRIRFKDGSSLEADLIVMAAGIRPNDELAVSAGIKVNR--GIIVNDSMQTSDPDIYAVGECAEHN 277
Pyr_redox_dim pfam02852
Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both ...
 199-276 1.80e-09

Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.


Pssm-ID: 427019 [Multi-domain]  Cd Length: 109  Bit Score: 54.10  E-value: 1.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 199 IFSTVIMERAFASAGVTEVQAKMQNLDIVTGT--FEGMNRhpATIPDAVKQSVKLIAMNHSGRIIGGQIVgGPEVGELIS 276
Cdd:pfam02852   1 IPSVVFTDPEIASVGLTEEEAKEKGGEVKVGKfpFAANGR--ALAYGDTDGFVKLVADRETGKILGAHIV-GPNAGELIQ 77
 
Name Accession Description Interval E-value
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 8-184 4.25e-47

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 159.98  E-value: 4.25e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   8 DQIKAYVDTK--QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTaFDVELASQAEELAKKVGMTLELGNYVDSI 85
Cdd:COG0446   113 DALREALKEFkgKRAVVIGGGPIGLELAEALRKRGLKVTLVERAPRLLGV-LDPEMAALLEEELREHGVELRLGETVVAI 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  86 KEENGIvtGVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRDFITREPS 165
Cdd:COG0446   192 DGDDKV--AVTLTDGEEIPADLVVVAPGVRPNTELAKDAGLALGERGWIKVDETLQTSDPDVYAAGDCAEVPHPVTGKTV 269

                         170
                  ....*....|....*....
gi 1176161350 166 KVMLASTSVAEARAAGSSL 184
Cdd:COG0446   270 YIPLASAANKQGRVAAENI 288
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 17-267 3.02e-45

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 158.28  E-value: 3.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  17 KQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDVELASQAEELAKKVGMTLELGNYVDSIKEENGiVTGVE 96
Cdd:PRK09564  149 IKNIVIIGAGFIGLEAVEAAKHLGKNVRIIQLEDRILPDSFDKEITDVMEEELRENGVELHLNEFVKSLIGEDK-VEGVV 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  97 LCGGKvIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRDFITREPSKVMLASTSVAE 176
Cdd:PRK09564  228 TDKGE-YEADVVIVATGVKPNTEFLEDTGLKTLKNGAIIVDEYGETSIENIYAAGDCATIYNIVSNKNVYVPLATTANKL 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 177 ARAAGSSLY-KIKYIKGFNGTIAIfstVIMERAFASAGVTEVQAKMQNLDIVTGTFEGMNrHPATIPDAVKQSVKLIAMN 255
Cdd:PRK09564  307 GRMVGENLAgRHVSFKGTLGSACI---KVLDLEAARTGLTEEEAKKLGIDYKTVFIKDKN-HTNYYPGQEDLYVKLIYEA 382

                         250
                  ....*....|..
gi 1176161350 256 HSGRIIGGQIVG 267
Cdd:PRK09564  383 DTKVILGGQIIG 394
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
8-270 4.99e-42

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 148.75  E-value: 4.99e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   8 DQIKAYVDTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDVELASQAEELAKKVGMTLELGNYVDSIKE 87
Cdd:COG1251   133 DALRAALAPGKRVVVIGGGLIGLEAAAALRKRGLEVTVVERAPRLLPRQLDEEAGALLQRLLEALGVEVRLGTGVTEIEG 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  88 ENGiVTGVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARygGIWVDEYMRTRDHDIFAVGDCAARRDFITREPsKV 167
Cdd:COG1251   213 DDR-VTGVRLADGEELPADLVVVAIGVRPNTELARAAGLAVDR--GIVVDDYLRTSDPDIYAAGDCAEHPGPVYGRR-VL 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 168 MLASTSVAEARAAGSSLYKIKyiKGFNGTIAIFSTVIMERAFASAGVTEvqakMQNLDIVTGtfegmnrhpatipDAVKQ 247
Cdd:COG1251   289 ELVAPAYEQARVAAANLAGGP--AAYEGSVPSTKLKVFGVDVASAGDAE----GDEEVVVRG-------------DPARG 349

                         250       260
                  ....*....|....*....|...
gi 1176161350 248 SVKLIAMnHSGRIIGGQIVGGPE 270
Cdd:COG1251   350 VYKKLVL-RDGRLVGAVLVGDTS 371
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 18-276 1.51e-38

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 140.61  E-value: 1.51e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTaFDVELASQAEELAKKVGMTLELGNYVDSIKEENGIVTgVEL 97
Cdd:COG1249   169 KSLVVIGGGYIGLEFAQIFARLGSEVTLVERGDRLLPG-EDPEISEALEKALEKEGIDILTGAKVTSVEKTGDGVT-VTL 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  98 CGGKVIKS---EVVILATGYKPETDL--AKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARrdfitrepskVMLAST 172
Cdd:COG1249   247 EDGGGEEAveaDKVLVATGRRPNTDGlgLEAAGVELDERGGIKVDEYLRTSVPGIYAIGDVTGG----------PQLAHV 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 173 SVAEARAAGSSLYKIKyIKGFNGTI---AIFSTVimerAFASAGVTEVQAKMQNLDIVTGT--FEGMNRhpATIPDAVKQ 247
Cdd:COG1249   317 ASAEGRVAAENILGKK-PRPVDYRAipsVVFTDP----EIASVGLTEEEAREAGIDVKVGKfpFAANGR--ALALGETEG 389

                         250       260
                  ....*....|....*....|....*....
gi 1176161350 248 SVKLIAMNHSGRIIGGQIVgGPEVGELIS 276
Cdd:COG1249   390 FVKLIADAETGRILGAHIV-GPHAGELIH 417
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
8-154 5.07e-36

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 132.35  E-value: 5.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   8 DQIKAYVDTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDVELASQAEELAKKVGMTLELGNYVDSI-K 86
Cdd:PRK04965  132 RAAETQLRDAQRVLVVGGGLIGTELAMDLCRAGKAVTLVDNAASLLASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLeK 211

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161350  87 EENGIVtgVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARygGIWVDEYMRTRDHDIFAVGDCA 154
Cdd:PRK04965  212 TDSGIR--ATLDSGRSIEVDAVIAAAGLRPNTALARRAGLAVNR--GIVVDSYLQTSAPDIYALGDCA 275
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 13-177 2.15e-33

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 123.58  E-value: 2.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  13 YVDTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNtAFDVELASQAEELAKKVGMTLELGNYVDSIKEENGIV 92
Cdd:pfam07992 148 LKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEALDRLLR-AFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGDGV 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  93 TgVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRdfitrepskVMLAST 172
Cdd:pfam07992 227 E-VILKDGTEIDADLVVVAIGRRPNTELLEAAGLELDERGGIVVDEYLRTSVPGIYAAGDCRVGG---------PELAQN 296


                  ....*
gi 1176161350 173 SVAEA 177
Cdd:pfam07992 297 AVAQG 301
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 18-275 2.95e-31

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 121.05  E-value: 2.95e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTaFDVELASQAEELAKKVgMTLELGNYVDSIKEENGIVTGVEL 97
Cdd:PRK06292  170 KSLAVIGGGVIGLELGQALSRLGVKVTVFERGDRILPL-EDPEVSKQAQKILSKE-FKIKLGAKVTSVEKSGDEKVEELE 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  98 CGGKV--IKSEVVILATGYKPETDL--AKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRdfitrepskvMLASTS 173
Cdd:PRK06292  248 KGGKTetIEADYVLVATGRRPNTDGlgLENTGIELDERGRPVVDEHTQTSVPGIYAAGDVNGKP----------PLLHEA 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 174 VAEARAAGSSLykIKYIKGFNGTIAIFSTVIMERAFASAGVTEVQAKMQNLDIVTGTFEGMNRHPATIPDAVKQSVKLIA 253
Cdd:PRK06292  318 ADEGRIAAENA--AGDVAGGVRYHPIPSVVFTDPQIASVGLTEEELKAAGIDYVVGEVPFEAQGRARVMGKNDGFVKVYA 395

                         250       260
                  ....*....|....*....|..
gi 1176161350 254 MNHSGRIIGGQIVgGPEVGELI 275
Cdd:PRK06292  396 DKKTGRLLGAHII-GPDAEHLI 416
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 18-276 4.35e-28

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 112.16  E-value: 4.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTaFDVELASQAEELAKKVGMTLELGNYVDSIKE-ENGIVTGVE 96
Cdd:PRK06416  173 KSLVVIGGGYIGVEFASAYASLGAEVTIVEALPRILPG-EDKEISKLAERALKKRGIKIKTGAKAKKVEQtDDGVTVTLE 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  97 LCGG-KVIKSEVVILATGYKPETD---LAkKAGLKLARyGGIWVDEYMRTRDHDIFAVGDCAArrdfitrepsKVMLAST 172
Cdd:PRK06416  252 DGGKeETLEADYVLVAVGRRPNTEnlgLE-ELGVKTDR-GFIEVDEQLRTNVPNIYAIGDIVG----------GPMLAHK 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 173 SVAEARAAgsslykIKYIKGFNGTI-------AIFStvimERAFASAGVTEVQAKMQNLDIVTGT--FEGMNRhpATIPD 243
Cdd:PRK06416  320 ASAEGIIA------AEAIAGNPHPIdyrgipaVTYT----HPEVASVGLTEAKAKEEGFDVKVVKfpFAGNGK--ALALG 387

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1176161350 244 AVKQSVKLIAMNHSGRIIGGQIVgGPEVGELIS 276
Cdd:PRK06416  388 ETDGFVKLIFDKKDGEVLGAHMV-GARASELIQ 419
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
 18-276 5.65e-22

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 94.99  E-value: 5.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAfDVELASQAEELAKKVGMTLELGNYVDSIKE-ENGIVTGVE 96
Cdd:PRK06327  184 KKLAVIGAGVIGLELGSVWRRLGAEVTILEALPAFLAAA-DEQVAKEAAKAFTKQGLDIHLGVKIGEIKTgGKGVSVAYT 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  97 LCGGKVIKSEV--VILATGYKPETD--LAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDcaarrdfITREPskvMLAST 172
Cdd:PRK06327  263 DADGEAQTLEVdkLIVSIGRVPNTDglGLEAVGLKLDERGFIPVDDHCRTNVPNVYAIGD-------VVRGP---MLAHK 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 173 SVAEARAAGSSlykikyIKGFNGTI---AIFSTVIMERAFASAGVTEVQAKMQNLDIVTGTFEGMNRHPATIPDAVKQSV 249
Cdd:PRK06327  333 AEEEGVAVAER------IAGQKGHIdynTIPWVIYTSPEIAWVGKTEQQLKAEGVEYKAGKFPFMANGRALAMGEPDGFV 406

                         250       260
                  ....*....|....*....|....*..
gi 1176161350 250 KLIAMNHSGRIIGGQIVgGPEVGELIS 276
Cdd:PRK06327  407 KIIADAKTDEILGVHVI-GPNASELIA 432
PRK06370 PRK06370
FAD-containing oxidoreductase;
18-276 3.66e-21

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 92.57  E-value: 3.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTaFDVELASQAEELAKKVGMTLELGNYVDSI-KEENGIVTGVE 96
Cdd:PRK06370  172 EHLVIIGGGYIGLEFAQMFRRFGSEVTVIERGPRLLPR-EDEDVAAAVREILEREGIDVRLNAECIRVeRDGDGIAVGLD 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  97 LCGGK--VIKSEvVILATGYKPETD---LAkKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRDFITrepskvmlas 171
Cdd:PRK06370  251 CNGGApeITGSH-ILVAVGRVPNTDdlgLE-AAGVETDARGYIKVDDQLRTTNPGIYAAGDCNGRGAFTH---------- 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 172 TSVAEAR-AAGSSLykikyikgFNGTIAIfSTVIMERA------FASAGVTEVQAKMQNLDIVTGTFEgMNRHPATIPDA 244
Cdd:PRK06370  319 TAYNDARiVAANLL--------DGGRRKV-SDRIVPYAtytdppLARVGMTEAEARKSGRRVLVGTRP-MTRVGRAVEKG 388

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1176161350 245 VKQS-VKLIAMNHSGRIIGGQIVgGPEVGELIS 276
Cdd:PRK06370  389 ETQGfMKVVVDADTDRILGATIL-GVHGDEMIH 420
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
11-181 4.80e-21

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 91.73  E-value: 4.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  11 KAYVDTKQRVTIVGSGFIGVEIGLEFAKSGK-------------EVTIIDGAEHILNtAFDVELASQAEELAKKVGMTLE 77
Cdd:COG1252   143 RAERRRLLTIVVVGGGPTGVELAGELAELLRkllrypgidpdkvRITLVEAGPRILP-GLGEKLSEAAEKELEKRGVEVH 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  78 LGNYVDSIKEEngivtGVELCGGKVIKSEVVILATGYKPeTDLAKKAGLKLARYGGIWVDEYMRTRDHD-IFAVGDCAAR 156
Cdd:COG1252   222 TGTRVTEVDAD-----GVTLEDGEEIPADTVIWAAGVKA-PPLLADLGLPTDRRGRVLVDPTLQVPGHPnVFAIGDCAAV 295

                         170       180
                  ....*....|....*....|....*
gi 1176161350 157 RDFITREPSKVmlASTSVAEARAAG 181
Cdd:COG1252   296 PDPDGKPVPKT--AQAAVQQAKVLA 318
PRK07846 PRK07846
mycothione reductase; Reviewed
 18-275 9.27e-20

mycothione reductase; Reviewed


Pssm-ID: 181142 [Multi-domain]  Cd Length: 451  Bit Score: 88.47  E-value: 9.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILnTAFDVELASQAEELAKKvGMTLELGNYVDSIKEENGIVTgVEL 97
Cdd:PRK07846  167 ESLVIVGGGFIAAEFAHVFSALGVRVTVVNRSGRLL-RHLDDDISERFTELASK-RWDVRLGRNVVGVSQDGSGVT-LRL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  98 CGGKVIKSEVVILATGYKPETDL--AKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAarrdfitrepSKVMLASTSVA 175
Cdd:PRK07846  244 DDGSTVEADVLLVATGRVPNGDLldAAAAGVDVDEDGRVVVDEYQRTSAEGVFALGDVS----------SPYQLKHVANH 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 176 EARAAGSSLYKIKYIKGFNGTI---AIFStvimERAFASAGVTEVQAKMQNLDIVTGTFE------GMNRHPATipdavk 246
Cdd:PRK07846  314 EARVVQHNLLHPDDLIASDHRFvpaAVFT----HPQIASVGLTENEARAAGLDITVKVQNygdvayGWAMEDTT------ 383

                         250       260
                  ....*....|....*....|....*....
gi 1176161350 247 QSVKLIAMNHSGRIIGGQIVgGPEVGELI 275
Cdd:PRK07846  384 GFVKLIADRDTGRLLGAHII-GPQASTLI 411
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
18-186 5.30e-19

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 84.79  E-value: 5.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIdgaehILNTAFDVELASQaEELAKKVGMTLELGNYVDSIKEENGiVTGVEL 97
Cdd:COG0492   142 KDVVVVGGGDSALEEALYLTKFASKVTLI-----HRRDELRASKILV-ERLRANPKIEVLWNTEVTEIEGDGR-VEGVTL 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  98 CGGK-----VIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARrdfitrepsKVMLAST 172
Cdd:COG0492   215 KNVKtgeekELEVDGVFVAIGLKPNTELLKGLGLELDEDGYIVVDEDMETSVPGVFAAGDVRDY---------KYRQAAT 285

                         170
                  ....*....|....
gi 1176161350 173 SVAEARAAGSSLYK 186
Cdd:COG0492   286 AAGEGAIAALSAAR 299
PRK06116 PRK06116
glutathione reductase; Validated
 18-275 2.31e-18

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 84.44  E-value: 2.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTaFDVELASQ-AEELAKKvGMTLELGNYVDSI-KEENGIVTgV 95
Cdd:PRK06116  168 KRVAVVGAGYIAVEFAGVLNGLGSETHLFVRGDAPLRG-FDPDIRETlVEEMEKK-GIRLHTNAVPKAVeKNADGSLT-L 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  96 ELCGGKVIKSEVVILATGYKPETD---LAKkAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARrdfitrepskVMLAST 172
Cdd:PRK06116  245 TLEDGETLTVDCLIWAIGREPNTDglgLEN-AGVKLNEKGYIIVDEYQNTNVPGIYAVGDVTGR----------VELTPV 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 173 SVAEARAAGSSLYKIKYIKGF---NGTIAIFSTvimeRAFASAGVTEVQAKMQ----NLDIVTGTFEGMNrhpATIPDAV 245
Cdd:PRK06116  314 AIAAGRRLSERLFNNKPDEKLdysNIPTVVFSH----PPIGTVGLTEEEAREQygedNVKVYRSSFTPMY---TALTGHR 386

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1176161350 246 KQS-VKLIAMNHSGRIIGGQIVgGPEVGELI 275
Cdd:PRK06116  387 QPClMKLVVVGKEEKVVGLHGI-GFGADEMI 416
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 8-157 3.45e-18

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 84.49  E-value: 3.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   8 DQIKAYVDTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDVELASQAEELAKKVGMTLELGNYVDSIKE 87
Cdd:TIGR02374 131 DAIMAMAQRFKKAAVIGGGLLGLEAAVGLQNLGMDVSVIHHAPGLMAKQLDQTAGRLLQRELEQKGLTFLLEKDTVEIVG 210

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  88 EnGIVTGVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARygGIWVDEYMRTRDHDIFAVGDCAARR 157
Cdd:TIGR02374 211 A-TKADRIRFKDGSSLEADLIVMAAGIRPNDELAVSAGIKVNR--GIIVNDSMQTSDPDIYAVGECAEHN 277
PRK13748 PRK13748
putative mercuric reductase; Provisional
 18-275 2.42e-14

putative mercuric reductase; Provisional


Pssm-ID: 184298 [Multi-domain]  Cd Length: 561  Bit Score: 72.88  E-value: 2.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIdgAEHILNTAFDVELASQAEELAKKVGMTLELGNYVDSIKEENG---IVTG 94
Cdd:PRK13748  271 ERLAVIGSSVVALELAQAFARLGSKVTIL--ARSTLFFREDPAIGEAVTAAFRAEGIEVLEHTQASQVAHVDGefvLTTG 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  95 V-ELCGGKVIksevviLATGYKPET-DLA-KKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCaarrdfiTREPSKVMLAS 171
Cdd:PRK13748  349 HgELRADKLL------VATGRAPNTrSLAlDAAGVTVNAQGAIVIDQGMRTSVPHIYAAGDC-------TDQPQFVYVAA 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 172 TsvAEARAAgsslykIKYIKGfNGTI---AIFSTVIMERAFASAGVTEVQAKMQNLDIVTGTFEGMNrhpatIPDAV--- 245
Cdd:PRK13748  416 A--AGTRAA------INMTGG-DAALdltAMPAVVFTDPQVATVGYSEAEAHHDGIETDSRTLTLDN-----VPRALanf 481

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1176161350 246 --KQSVKLIAMNHSGRIIGGQIVgGPEVGELI 275
Cdd:PRK13748  482 dtRGFIKLVIEEGSGRLIGVQAV-APEAGELI 512
Nterm_to_SelD TIGR03169
pyridine nucleotide-disulfide oxidoreductase family protein; Members of this protein family ...
 15-155 3.46e-14

pyridine nucleotide-disulfide oxidoreductase family protein; Members of this protein family include N-terminal sequence regions of (probable) bifunctional proteins whose C-terminal sequences are SelD, or selenide,water dikinase, the selenium donor protein necessary for selenium incorporation into protein (as selenocysteine), tRNA (as 2-selenouridine), or both. However, some members of this family occur in species that do not show selenium incorporation, and the function of this protein family is unknown.


Pssm-ID: 274465  Cd Length: 364  Bit Score: 71.85  E-value: 3.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  15 DTKQRVTIVGSGFIGVEIGLEFAK------SGKEVTIIDGAEHILnTAFDVELASQAEELAKKVGMTLELGNYVDSIKEe 88
Cdd:TIGR03169 142 QQPPRIAVIGGGAAGVELALAMAHrlrqlgRNAEVTLIDRGNVLL-PGHNARVRRRLERALQERGVTLHLGATVAEVTA- 219

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161350  89 ngivTGVELCGGKVIKSEVVILATGYKPETDLAKkAGLKLARYGGIWVDEYMRTRDH-DIFAVGDCAA 155
Cdd:TIGR03169 220 ----DAVRLEDGQTLPADFTFWATGARPPGWLAE-SGLALDEDGFIRVGPTLQSLSHpDIFAAGDCAH 282
PRK07251 PRK07251
FAD-containing oxidoreductase;
18-277 1.44e-13

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 70.16  E-value: 1.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAfDVELASQAEELAKKVGMTLELGNYVDSIKEENGIVtgVEL 97
Cdd:PRK07251  158 ERLGIIGGGNIGLEFAGLYNKLGSKVTVLDAASTILPRE-EPSVAALAKQYMEEDGITFLLNAHTTEVKNDGDQV--LVV 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  98 CGGKVIKSEVVILATGYKPET-DLA-KKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRDFitrepSKVMLASTSVA 175
Cdd:PRK07251  235 TEDETYRFDALLYATGRKPNTePLGlENTDIELTERGAIKVDDYCQTSVPGVFAVGDVNGGPQF-----TYISLDDFRIV 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 176 EARAAGSSLYKIKYIKgfngtiAIFSTVIMERAFASAGVTEVQAKMQNLDIVTGTFEGMNRHPATIPDAVKQSVKLIAMN 255
Cdd:PRK07251  310 FGYLTGDGSYTLEDRG------NVPTTMFITPPLSQVGLTEKEAKEAGLPYAVKELLVAAMPRAHVNNDLRGAFKVVVNT 383

                         250       260
                  ....*....|....*....|....
gi 1176161350 256 HSGRIIGGQIVG--GPEVGELISM 277
Cdd:PRK07251  384 ETKEILGATLFGegSQEIINLITM 407
PRK13512 PRK13512
coenzyme A disulfide reductase; Provisional
 8-267 5.40e-13

coenzyme A disulfide reductase; Provisional


Pssm-ID: 184103 [Multi-domain]  Cd Length: 438  Bit Score: 68.66  E-value: 5.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   8 DQIKAYVDTKQ--RVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHIlNTAFDVELASQAEELAKKVGMTLELGNYVDSI 85
Cdd:PRK13512  137 DAIDQFIKANQvdKALVVGAGYISLEVLENLYERGLHPTLIHRSDKI-NKLMDADMNQPILDELDKREIPYRLNEEIDAI 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  86 KEENgivtgVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRDFITREPS 165
Cdd:PRK13512  216 NGNE-----VTFKSGKVEHYDMIIEGVGTHPNSKFIESSNIKLDDKGFIPVNDKFETNVPNIYAIGDIITSHYRHVDLPA 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 166 KVMLA-----STSVAEARAAGSSlyKIKYiKGFNGTIAIfstVIMERAFASAGVTEVQAKmqNLDIVTGTFEGMNrHPAT 240
Cdd:PRK13512  291 SVPLAwgahrAASIVAEQIAGND--TIEF-KGFLGNNIV---KFFDYTFASVGVKPNELK--QFDYKMVEVTQGA-HANY 361

                         250       260
                  ....*....|....*....|....*..
gi 1176161350 241 IPDAVKQSVKLIAMNHSGRIIGGQIVG 267
Cdd:PRK13512  362 YPGNSPLHLRVYYDTSNRKILRAAAVG 388
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 9-165 1.14e-12

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 67.64  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   9 QIKAYVDTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDVELASQAEELAKKVGMTLELGNYVDSIKEE 88
Cdd:PRK09754  136 RLREVLQPERSVVIVGAGTIGLELAASATQRRCKVTVIELAATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHVVDG 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176161350  89 NGIVtgVELCGGKVIKSEVVILATGYKPETDLAKKAGLklARYGGIWVDEYMRTRDHDIFAVGDCAarrdfITREPS 165
Cdd:PRK09754  216 EKVE--LTLQSGETLQADVVIYGIGISANDQLAREANL--DTANGIVIDEACRTCDPAIFAGGDVA-----ITRLDN 283
PRK08010 PRK08010
pyridine nucleotide-disulfide oxidoreductase; Provisional
 19-266 2.84e-12

pyridine nucleotide-disulfide oxidoreductase; Provisional


Pssm-ID: 181196 [Multi-domain]  Cd Length: 441  Bit Score: 66.58  E-value: 2.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  19 RVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAfDVELASQAEELAKKVGMTLELGNYVDSIKEENGIVTgVELC 98
Cdd:PRK08010  160 HLGILGGGYIGVEFASMFANFGSKVTILEAASLFLPRE-DRDIADNIATILRDQGVDIILNAHVERISHHENQVQ-VHSE 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  99 GGKVIkSEVVILATGYKPETD--LAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARRDF--ITREPSKVmLASTSV 174
Cdd:PRK08010  238 HAQLA-VDALLIASGRQPATAslHPENAGIAVNERGAIVVDKYLHTTADNIWAMGDVTGGLQFtyISLDDYRI-VRDELL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 175 AEARAAGSSLYKIKYikgfngtiaifsTVIMERAFASAGVTEVQAKMQNLDIVTGTFEGMNRHPATIPDAVKQSVKLIAM 254
Cdd:PRK08010  316 GEGKRSTDDRKNVPY------------SVFMTPPLSRVGMTEEQARESGADIQVVTLPVAAIPRARVMNDTRGVLKAIVD 383

                         250
                  ....*....|..
gi 1176161350 255 NHSGRIIGGQIV 266
Cdd:PRK08010  384 NKTQRILGASLL 395
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
8-182 4.06e-12

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 65.95  E-value: 4.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350   8 DQIKAYVDTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILntAF-DVELaSQA-----EELakkvGMTLELGNY 81
Cdd:PRK05249  166 DSILSLDHLPRSLIIYGAGVIGCEYASIFAALGVKVTLINTRDRLL--SFlDDEI-SDAlsyhlRDS----GVTIRHNEE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  82 VDSIKEENGIVTgVELCGGKVIKSEVVILATGYKPETD-LA-KKAGLKLARYGGIWVDEYMRTR-DHdIFAVGDcaarrd 158
Cdd:PRK05249  239 VEKVEGGDDGVI-VHLKSGKKIKADCLLYANGRTGNTDgLNlENAGLEADSRGQLKVNENYQTAvPH-IYAVGD------ 310

                         170       180
                  ....*....|....*....|....
gi 1176161350 159 fITREPSkvmLASTSVAEARAAGS 182
Cdd:PRK05249  311 -VIGFPS---LASASMDQGRIAAQ 330
PLN02546 PLN02546
glutathione reductase
 18-271 5.28e-11

glutathione reductase


Pssm-ID: 215301 [Multi-domain]  Cd Length: 558  Bit Score: 62.97  E-value: 5.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNtAFDVELASQAEELAKKVGMTLELGNYVDSIKEENGIVTGVEL 97
Cdd:PLN02546  253 EKIAIVGGGYIALEFAGIFNGLKSDVHVFIRQKKVLR-GFDEEVRDFVAEQMSLRGIEFHTEESPQAIIKSADGSLSLKT 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  98 CGGKVIKSEVVILATGYKPET-DLA-KKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARrdfitrepskVMLASTSVA 175
Cdd:PLN02546  332 NKGTVEGFSHVMFATGRKPNTkNLGlEEVGVKMDKNGAIEVDEYSRTSVPSIWAVGDVTDR----------INLTPVALM 401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 176 EARAAGSSLYKIKYIKGfnGTIAIFSTVIMERAFASAGVTEVQAKMQ--NLDIVTGTFEGMNRHPATIPDAVkqSVKLIA 253
Cdd:PLN02546  402 EGGALAKTLFGNEPTKP--DYRAVPSAVFSQPPIGQVGLTEEQAIEEygDVDVFTANFRPLKATLSGLPDRV--FMKLIV 477

                         250       260
                  ....*....|....*....|
gi 1176161350 254 MNHSGRIIGGQIVG--GPEV 271
Cdd:PLN02546  478 CAKTNKVLGVHMCGedAPEI 497
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
17-151 6.66e-11

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 61.47  E-value: 6.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  17 KQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDVelaSQA---------EELAKKVGMTLELGNYVDSIKE 87
Cdd:pfam13738 155 GQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEWEDRDSDP---SYSlspdtlnrlEELVKNGKIKAHFNAEVKEITE 231

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176161350  88 ENGIVTgVELCGGKVIKSE-VVILATGYKPETDLAKKAGLKLARYGGIWVD-EYMRTRDHDIFAVG 151
Cdd:pfam13738 232 VDVSYK-VHTEDGRKVTSNdDPILATGYHPDLSFLKKGLFELDEDGRPVLTeETESTNVPGLFLAG 296
PTZ00058 PTZ00058
glutathione reductase; Provisional
 18-153 2.02e-10

glutathione reductase; Provisional


Pssm-ID: 185420 [Multi-domain]  Cd Length: 561  Bit Score: 61.17  E-value: 2.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTaFDVELASQAEELAKKVGMTLELGNYVDSIK--EENGIVTGV 95
Cdd:PTZ00058  238 KRIGIAGSGYIAVELINVVNRLGAESYIFARGNRLLRK-FDETIINELENDMKKNNINIITHANVEEIEkvKEKNLTIYL 316

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1176161350  96 ELcGGKVIKSEVVILATGYKPET-DLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDC 153
Cdd:PTZ00058  317 SD-GRKYEHFDYVIYCVGRSPNTeDLNLKALNIKTPKGYIKVDDNQRTSVKHIYAVGDC 374
trypano_reduc TIGR01423
trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of ...
 18-271 2.86e-10

trypanothione-disulfide reductase; Trypanothione, a glutathione-modified derivative of spermidine, is (in its reduced form) an important antioxidant found in trypanosomatids (Crithidia, Leishmania, Trypanosoma). This model describes trypanothione reductase, a possible antitrypanosomal drug target closely related to some forms of glutathione reductase.


Pssm-ID: 200098 [Multi-domain]  Cd Length: 486  Bit Score: 60.37  E-value: 2.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVE---IGLEFAKSGKEVTIIDGAEHILNtAFDVELASQAEELAKKVGMTLELGNYVDSIKEENGIVTG 94
Cdd:TIGR01423 188 RRVLTVGGGFISVEfagIFNAYKPRGGKVTLCYRNNMILR-GFDSTLRKELTKQLRANGINIMTNENPAKVTLNADGSKH 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  95 VELCGGKVIKSEVVILATGYKPETDLAK--KAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARrdfitrepskVMLAST 172
Cdd:TIGR01423 267 VTFESGKTLDVDVVMMAIGRVPRTQTLQldKVGVELTKKGAIQVDEFSRTNVPNIYAIGDVTDR----------VMLTPV 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 173 SVAEARAAGSSLYKIKYIKGFNGTIAifSTVIMERAFASAGVTEVQA--KMQNLDIVTGTFEGMNRHPATipDAVKQSVK 250
Cdd:TIGR01423 337 AINEGAAFVDTVFGNKPRKTDHTRVA--SAVFSIPPIGTCGLVEEDAakKFEKVAVYESSFTPLMHNISG--SKYKKFVA 412

                         250       260
                  ....*....|....*....|....
gi 1176161350 251 LIAMNHS-GRIIGGQIVG--GPEV 271
Cdd:TIGR01423 413 KIVTNHAdGTVLGVHLLGdsSPEI 436
PRK07845 PRK07845
flavoprotein disulfide reductase; Reviewed
 22-275 3.28e-10

flavoprotein disulfide reductase; Reviewed


Pssm-ID: 236112 [Multi-domain]  Cd Length: 466  Bit Score: 60.26  E-value: 3.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  22 IVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAfDVELASQAEELAKKVGMTLELGNYVDSIK-EENGIVtgVELCGG 100
Cdd:PRK07845  182 VVGSGVTGAEFASAYTELGVKVTLVSSRDRVLPGE-DADAAEVLEEVFARRGMTVLKRSRAESVErTGDGVV--VTLTDG 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 101 KVIKSEVVILATGYKPET-DLA-KKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAArrdfitrepsKVMLASTS----- 173
Cdd:PRK07845  259 RTVEGSHALMAVGSVPNTaGLGlEEAGVELTPSGHITVDRVSRTSVPGIYAAGDCTG----------VLPLASVAamqgr 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 174 VAEARAAGSSLYKIKYikgfnGTIAifSTVIMERAFASAGVTE-------VQAKMQNLDIvtgtfegmnrhpATIPDAVK 246
Cdd:PRK07845  329 IAMYHALGEAVSPLRL-----KTVA--SNVFTRPEIATVGVSQaaidsgeVPARTVMLPL------------ATNPRAKM 389

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1176161350 247 QS-----VKLIAMNHSGRIIGGQIVgGPEVGELI 275
Cdd:PRK07845  390 SGlrdgfVKLFCRPGTGVVIGGVVV-APRASELI 422
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 19-100 6.44e-10

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 54.52  E-value: 6.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  19 RVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNtAFDVELASQAEELAKKVGMTLELGNYVDSIkEENGIVTGVELC 98
Cdd:pfam00070   1 RVVVVGGGYIGLELAGALARLGSKVTVVERRDRLLP-GFDPEIAKILQEKLEKNGIEFLLNTTVEAI-EGNGDGVVVVLT 78


                  ..
gi 1176161350  99 GG 100
Cdd:pfam00070  79 DG 80
Pyr_redox_dim pfam02852
Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both ...
 199-276 1.80e-09

Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.


Pssm-ID: 427019 [Multi-domain]  Cd Length: 109  Bit Score: 54.10  E-value: 1.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 199 IFSTVIMERAFASAGVTEVQAKMQNLDIVTGT--FEGMNRhpATIPDAVKQSVKLIAMNHSGRIIGGQIVgGPEVGELIS 276
Cdd:pfam02852   1 IPSVVFTDPEIASVGLTEEEAKEKGGEVKVGKfpFAANGR--ALAYGDTDGFVKLVADRETGKILGAHIV-GPNAGELIQ 77
PLN02507 PLN02507
glutathione reductase
 15-275 5.82e-09

glutathione reductase


Pssm-ID: 215281 [Multi-domain]  Cd Length: 499  Bit Score: 56.36  E-value: 5.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  15 DTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILnTAFDVEL-ASQAEELAKKvGMTLELG-NYVDSIKEENGIv 92
Cdd:PLN02507  201 ELPKRAVVLGGGYIAVEFASIWRGMGATVDLFFRKELPL-RGFDDEMrAVVARNLEGR-GINLHPRtNLTQLTKTEGGI- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  93 tGVELCGGKVIKSEVVILATGYKPETDLA--KKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAARrdfITREPSKVMLA 170
Cdd:PLN02507  278 -KVITDHGEEFVADVVLFATGRAPNTKRLnlEAVGVELDKAGAVKVDEYSRTNIPSIWAIGDVTNR---INLTPVALMEG 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 171 sTSVAEARAAGSSLyKIKYIkgfNGTIAIFSTVIMerafASAGVTEVQAKMQ-NLDIV--TGTFEGMNRhpaTIPDAVKQ 247
Cdd:PLN02507  354 -TCFAKTVFGGQPT-KPDYE---NVACAVFCIPPL----SVVGLSEEEAVEQaKGDILvfTSSFNPMKN---TISGRQEK 421

                         250       260
                  ....*....|....*....|....*....
gi 1176161350 248 SV-KLIAMNHSGRIIGGQIVgGPEVGELI 275
Cdd:PLN02507  422 TVmKLIVDAETDKVLGASMC-GPDAPEIM 449
PRK14989 PRK14989
nitrite reductase subunit NirD; Provisional
 10-155 2.26e-08

nitrite reductase subunit NirD; Provisional


Pssm-ID: 184951 [Multi-domain]  Cd Length: 847  Bit Score: 55.12  E-value: 2.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  10 IKAYVDTKQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDVELASQAEELAKKVGMTLELG-NYVDSIKEE 88
Cdd:PRK14989  138 IEACARRSKRGAVVGGGLLGLEAAGALKNLGVETHVIEFAPMLMAEQLDQMGGEQLRRKIESMGVRVHTSkNTLEIVQEG 217

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176161350  89 NGIVTGVELCGGKVIKSEVVILATGYKPETDLAKKAGLKLARYGGIWVDEYMRTRDHDIFAVGDCAA 155
Cdd:PRK14989  218 VEARKTMRFADGSELEVDFIVFSTGIRPQDKLATQCGLAVAPRGGIVINDSCQTSDPDIYAIGECAS 284
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 85-180 1.36e-06

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 48.98  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  85 IKEENGIVTGVELC---------GGK-----------VIKSEVVILATGYKPETD-LAKKAGLKLARYGGIWVDE-YMRT 142
Cdd:COG0493   320 IGDENGRVTGLECVrmelgepdeSGRrrpvpiegsefTLPADLVILAIGQTPDPSgLEEELGLELDKRGTIVVDEeTYQT 399

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1176161350 143 RDHDIFAVGDCAarrdfitREPSKVMLAstsVAEARAA 180
Cdd:COG0493   400 SLPGVFAGGDAV-------RGPSLVVWA---IAEGRKA 427
TRX_reduct TIGR01292
thioredoxin-disulfide reductase; This model describes thioredoxin-disulfide reductase, a ...
 18-186 2.62e-06

thioredoxin-disulfide reductase; This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport]


Pssm-ID: 273540 [Multi-domain]  Cd Length: 299  Bit Score: 48.01  E-value: 2.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  18 QRVTIVGSGFIGVEIGLEFAKSGKEVTII---DG--AEHILntafdvelasqAEELAKKVGMTLELGNYVDSIKEENGI- 91
Cdd:TIGR01292 141 KEVAVVGGGDSAIEEALYLTRIAKKVTLVhrrDKfrAEKIL-----------LDRLKKNPKIEFLWNSTVEEIVGDNKVe 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  92 -------VTGVElcggKVIKSEVVILATGYKPETDLAKKAgLKLARYGGIWVDEYMRTRDHDIFAVGDCaarRDFITREp 164
Cdd:TIGR01292 210 gvkikntVTGEE----EELEVDGVFIAIGHEPNTELLKGL-LELDENGYIVTDEGMRTSVPGVFAAGDV---RDKGYRQ- 280

                         170       180
                  ....*....|....*....|..
gi 1176161350 165 skvmlASTSVAEARAAGSSLYK 186
Cdd:TIGR01292 281 -----AVTAAGDGCIAALSAER 297
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 22-154 6.13e-06

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 47.10  E-value: 6.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  22 IVGSGFIGVEIGLEFAKS------------GKEVTIIDGAehilNTAFDV---------------------EL-ASQAE- 66
Cdd:PRK11749  243 IPGENLGGVYSAVDFLTRvnqavadydlpvGKRVVVIGGG----NTAMDAartakrlgaesvtivyrrgreEMpASEEEv 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  67 ELAKKVGMTLELGNYVDSIKEENGIVTGVEL-----------------CGGK--VIKSEVVILATGYKPETDLAKKA-GL 126
Cdd:PRK11749  319 EHAKEEGVEFEWLAAPVEILGDEGRVTGVEFvrmelgepdasgrrrvpIEGSefTLPADLVIKAIGQTPNPLILSTTpGL 398

                         170       180
                  ....*....|....*....|....*....
gi 1176161350 127 KLARYGGIWVDE-YMRTRDHDIFAVGDCA 154
Cdd:PRK11749  399 ELNRWGTIIADDeTGRTSLPGVFAGGDIV 427
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 22-155 2.70e-05

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 45.14  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  22 IVGSGFIGVEIGLEFAKSGKE--------------VTIIDGAEHILNTaFDVELASQAEELAKKVGMTLELGNYVDSIKE 87
Cdd:PTZ00318  178 VVGGGPTGVEFAAELADFFRDdvrnlnpelveeckVTVLEAGSEVLGS-FDQALRKYGQRRLRRLGVDIRTKTAVKEVLD 256

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176161350  88 ENgivtgVELCGGKVIKSEVVILATGYKPETdLAKKAGLKLARYGGIWVDEYMRTRDH-DIFAVGDCAA 155
Cdd:PTZ00318  257 KE-----VVLKDGEVIPTGLVVWSTGVGPGP-LTKQLKVDKTSRGRISVDDHLRVKPIpNVFALGDCAA 319
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
20-116 1.55e-04

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 42.41  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  20 VTIVGSGFIGVEIGLEFAKSGKEVTIIDGAE--HILNTAFDV-------------ELASQAEELAKKVGMTLELGNyVDS 84
Cdd:COG0492     3 VVIIGAGPAGLTAAIYAARAGLKTLVIEGGEpgGQLATTKEIenypgfpegisgpELAERLREQAERFGAEILLEE-VTS 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1176161350  85 IKEENGIVTgVELCGGKVIKSEVVILATGYKP 116
Cdd:COG0492    82 VDKDDGPFR-VTTDDGTEYEAKAVIIATGAGP 112
PTZ00153 PTZ00153
lipoamide dehydrogenase; Provisional
 17-180 1.96e-04

lipoamide dehydrogenase; Provisional


Pssm-ID: 173442 [Multi-domain]  Cd Length: 659  Bit Score: 42.59  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  17 KQRVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILnTAFDVELASQAEEL-------------------AKKVGMTLE 77
Cdd:PTZ00153  312 QNYMGIVGMGIIGLEFMDIYTALGSEVVSFEYSPQLL-PLLDADVAKYFERVflkskpvrvhlntlieyvrAGKGNQPVI 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  78 LGNYVDSIKEENGivTGVELCGGKVIKSEVVILATGYKPETDLA--KKAGLKLARyGGIWVDEYMRTRDHD------IFA 149
Cdd:PTZ00153  391 IGHSERQTGESDG--PKKNMNDIKETYVDSCLVATGRKPNTNNLglDKLKIQMKR-GFVSVDEHLRVLREDqevydnIFC 467

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1176161350 150 VGDCAARRdfitrepskvMLASTSVAEARAA 180
Cdd:PTZ00153  468 IGDANGKQ----------MLAHTASHQALKV 488
TGR TIGR01438
thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member ...
 22-275 5.01e-04

thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member of the pyridine nucleotide disulfide oxidoreductase family contains a C-terminal motif Cys-SeCys-Gly, where SeCys is selenocysteine encoded by TGA (in some sequence reports interpreted as a stop codon). In some members of this subfamily, Cys-SeCys-Gly is replaced by Cys-Cys-Gly. The reach of the selenium atom at the C-term arm of the protein is proposed to allow broad substrate specificity.


Pssm-ID: 273624 [Multi-domain]  Cd Length: 484  Bit Score: 41.38  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  22 IVGSGFIGVEIGLEFAKSGKEVTIIdgAEHILNTAFDVELASQAEELAKKVGMTLElgNYVDSIK----EENGIVTGVEL 97
Cdd:TIGR01438 185 VVGASYVALECAGFLAGIGLDVTVM--VRSILLRGFDQDCANKVGEHMEEHGVKFK--RQFVPIKveqiEAKVLVEFTDS 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  98 CGGKVIKSEVVILATGYKPETDLA--KKAGLKL-ARYGGIWVDEYMRTRDHDIFAVGDCAArrdfitrepSKVMLASTSV 174
Cdd:TIGR01438 261 TNGIEEEYDTVLLAIGRDACTRKLnlENVGVKInKKTGKIPADEEEQTNVPYIYAVGDILE---------DKPELTPVAI 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 175 AEARAAGSSLYK-IKYIKGFNGtiaIFSTVIMERAFASAGVTEVQA----KMQNLDIVTGTFegmNRHPATIPDAVKQS- 248
Cdd:TIGR01438 332 QAGRLLAQRLFKgSTVICDYEN---VPTTVFTPLEYGACGLSEEKAvekfGEENVEVFHSYF---WPLEWTIPSRDNHNk 405

                         250       260       270
                  ....*....|....*....|....*....|
gi 1176161350 249 --VKLIAM-NHSGRIIGGQIVgGPEVGELI 275
Cdd:TIGR01438 406 cyAKLVCNkKENERVVGFHVV-GPNAGEVT 434
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 19-70 8.51e-04

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 40.41  E-value: 8.51e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1176161350  19 RVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHILNTAFDvELASQAEELAK 70
Cdd:PRK06129    4 SVAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPA-YIAGRLEDLAA 54
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
36-127 1.47e-03

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 39.57  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  36 FAKSGKEVTIIDGAEHILN---TAFDVELASQAEELakkvGMTLELGNYVDSIKEENGIVTgVELCGGKVIKSEVVILAT 112
Cdd:COG0644    64 YSPGGKSVELPPGRGGGYVvdrARFDRWLAEQAEEA----GAEVRTGTRVTDVLRDDGRVV-VRTGDGEEIRADYVVDAD 138

                          90
                  ....*....|....*
gi 1176161350 113 GYKPEtdLAKKAGLK 127
Cdd:COG0644   139 GARSL--LARKLGLK 151
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 103-184 2.62e-03

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 39.33  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350 103 IKSEVVILATGYKPETDLAKKAGLKLARYGGIWVD-EYMRTRDHDIFAVGDCAARRDfitrepskvmLASTSVAEARAAG 181
Cdd:PRK12814  424 LQADTVISAIGQQVDPPIAEAAGIGTSRNGTVKVDpETLQTSVAGVFAGGDCVTGAD----------IAINAVEQGKRAA 493


                  ...
gi 1176161350 182 SSL 184
Cdd:PRK12814  494 HAI 496
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 84-180 4.85e-03

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 38.22  E-value: 4.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  84 SIKEENGIVTGVELC----GG----------KVIKSEVVILATGYK-PETDLAKKAGLKLARYGGIWVDEY-MRTRDHDI 147
Cdd:PRK12810  354 EFEGENGKVTGVKVVrtelGEgdfepvegseFVLPADLVLLAMGFTgPEAGLLAQFGVELDERGRVAAPDNaYQTSNPKV 433

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1176161350 148 FAVGDCAARRDfitrepskvmLASTSVAEARAA 180
Cdd:PRK12810  434 FAAGDMRRGQS----------LVVWAIAEGRQA 456
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 19-133 8.92e-03

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 37.38  E-value: 8.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161350  19 RVTIVGSGFIGVEIGLEFAKSGKEVTIIDGAEHI------LNTAFdveLASQAEELAKK--VGMTLELGNYVDSIKEENG 90
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPgsgasgRNAGL---IHPGLRYLEPSelARLALEALDLWEELEEELG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1176161350  91 IVTGVELCGgkvikseVVILATGYKPEtDLAKKAGLkLARYGG 133
Cdd:pfam01266  78 IDCGFRRCG-------VLVLARDEEEE-ALEKLLAA-LRRLGV 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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