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Conserved domains on  [gi|1175880215|ref|XP_020593725|]
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zinc finger CCCH domain-containing protein 32-like [Phalaenopsis equestris]

Protein Classification

zinc finger CCCH domain-containing protein( domain architecture ID 709945)

zinc finger CCCH domain-containing protein similar to Arabidopsis thaliana zinc finger C-x8-C-x5-C-x3-H type family protein

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|27990022
SCOP:  3001741

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-CCCH_3 super family cl25863
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 21-139 1.57e-12

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


The actual alignment was detected with superfamily member pfam15663:

Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 64.41  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175880215  21 NTDCVYFLASplTCKKGSECEYRHSEDARINPRDCKFWLSGKCLNPKCFFRHPPLDGmivsprttsaktaafshvppsmp 100
Cdd:pfam15663   5 GDDCYFFYYS--TCTKGDSCPFRHCEAALGNETVCTLWQEGRCFRPVCRFRHMEIDK----------------------- 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1175880215 101 lpmakfftynfGRNNVPCYYYLK-GACLKgDKCPFMHGPP 139
Cdd:pfam15663  60 -----------NRKEIPCYWENQpGGCQK-PHCAFHHTKP 87
 
Name Accession Description Interval E-value
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 21-139 1.57e-12

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 64.41  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175880215  21 NTDCVYFLASplTCKKGSECEYRHSEDARINPRDCKFWLSGKCLNPKCFFRHPPLDGmivsprttsaktaafshvppsmp 100
Cdd:pfam15663   5 GDDCYFFYYS--TCTKGDSCPFRHCEAALGNETVCTLWQEGRCFRPVCRFRHMEIDK----------------------- 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1175880215 101 lpmakfftynfGRNNVPCYYYLK-GACLKgDKCPFMHGPP 139
Cdd:pfam15663  60 -----------NRKEIPCYWENQpGGCQK-PHCAFHHTKP 87
ZnF_C3H1 smart00356
zinc finger;
116-138 1.57e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.85  E-value: 1.57e-05
                           10        20
                   ....*....|....*....|...
gi 1175880215  116 VPCYYYLKGACLKGDKCPFMHGP 138
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 21-139 1.57e-12

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 64.41  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175880215  21 NTDCVYFLASplTCKKGSECEYRHSEDARINPRDCKFWLSGKCLNPKCFFRHPPLDGmivsprttsaktaafshvppsmp 100
Cdd:pfam15663   5 GDDCYFFYYS--TCTKGDSCPFRHCEAALGNETVCTLWQEGRCFRPVCRFRHMEIDK----------------------- 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1175880215 101 lpmakfftynfGRNNVPCYYYLK-GACLKgDKCPFMHGPP 139
Cdd:pfam15663  60 -----------NRKEIPCYWENQpGGCQK-PHCAFHHTKP 87
ZnF_C3H1 smart00356
zinc finger;
116-138 1.57e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.85  E-value: 1.57e-05
                           10        20
                   ....*....|....*....|...
gi 1175880215  116 VPCYYYLKGACLKGDKCPFMHGP 138
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 118-136 3.75e-05

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 40.86  E-value: 3.75e-05
                          10
                  ....*....|....*....
gi 1175880215 118 CYYYLKGACLKGDKCPFMH 136
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
zf-CCCH_2 pfam14608
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented ...
 117-137 4.18e-03

RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA.


Pssm-ID: 464217  Cd Length: 19  Bit Score: 35.18  E-value: 4.18e-03
                          10        20
                  ....*....|....*....|.
gi 1175880215 117 PCYYYlkGACLKGDKCPFMHG 137
Cdd:pfam14608   1 PCRFG--GNCTFGPKCPFSHP 19
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
116-138 7.65e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 34.48  E-value: 7.65e-03
                          10        20
                  ....*....|....*....|....
gi 1175880215 116 VPCYYYLK-GACLKGDKCPFMHGP 138
Cdd:pfam00642   4 ELCRFFLRtGYCKYGDRCKFAHGQ 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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