|
Name |
Accession |
Description |
Interval |
E-value |
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
1-423 |
0e+00 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 835.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 1 MFALADVNSFYASCEKVFRPDLRGKPVICLSNNDGCVIARSPEAKRrLGIKMGTPWFQLKDVQFPEKLFVFSSNYELYAS 80
Cdd:PRK03609 1 MFALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKA-LGIKMGDPWFKQKDLFRRCGVVCFSSNYELYAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 81 LSNRVVALLEELSPRVEQYSIDECFLDARGIGHCMDLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKEW-PQ 159
Cdd:PRK03609 80 MSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWqRQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 160 FRGVLALSpdNPGRTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKNFNVVLERTVRELNGESCISL 239
Cdd:PRK03609 160 TGGVVDLS--NLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 240 EEAPPPKQQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAVKEPYYGNISTEKLSTPTR 319
Cdd:PRK03609 238 EEFAPTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQ 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 320 DSRDIIAAAVNALDRIWVPGHRYAKAGVMLNDFCPNGVSQLNLFDEIQPRPHSDALMKVLDGIN-HSGLGKIWFAGRGIA 398
Cdd:PRK03609 318 DSRDIIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMKVLDTLNaKSGKGTLYFAGQGIA 397
|
410 420
....*....|....*....|....*
gi 1172515803 399 PEWQMKRDMLSPAYTTRWKELPVAR 423
Cdd:PRK03609 398 QQWQMKREMLSPRYTTRWSDLLRVK 422
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
3-351 |
1.08e-180 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 506.70 E-value: 1.08e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 3 ALADVNSFYASCEKVFRPDLRGKPVICLSNNDGCVIARSPEAKRrLGIKMGTPWFQLKDvqFPEKLF--VFSSNYELYAS 80
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKA-LGIKMGSPYFKVPD--LLERHGvaVFSSNYALYGD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 81 LSNRVVALLEELSPRVEQYSIDECFLDARGIGHCMDLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKEWPQF 160
Cdd:cd01700 78 MSRRIMSILERFSPDVEVYSIDESFLDLTGSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 161 RGVLALspDNPGRTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKNFNVVLERTVRELNGESCISLE 240
Cdd:cd01700 158 GGVVDL--TDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 241 EAPPPKQQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAVKEPYYGNisTEKLSTPTRD 320
Cdd:cd01700 236 EYPPPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYYSA--TNTLPYPTND 313
|
330 340 350
....*....|....*....|....*....|.
gi 1172515803 321 SRDIIAAAVNALDRIWVPGHRYAKAGVMLND 351
Cdd:cd01700 314 TREIVKAALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-349 |
3.43e-124 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 362.92 E-value: 3.43e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 1 MFALADVNSFYASCEKVFRPDLRGKPVI-CLSNNDGCVIARSPEAkRRLGIKMGTPWFQLKDVqFPEkLFVFSSNYELYA 79
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAvGGDNNRGVVAAASYEA-RAFGVRSGMPLFQARRL-CPD-LVVLPPDFELYR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 80 SLSNRVVALLEELSPRVEQYSIDECFLDARGIGHCM-DLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKEwp 158
Cdd:COG0389 79 DVSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFgSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 159 qfRGVLALSPdnpGRTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKNFNVVLERTVRELNGESCIS 238
Cdd:COG0389 157 --DGLTVIPP---GEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 239 LEEAPPPKqQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAVKEpyygniSTEKLSTPT 318
Cdd:COG0389 232 VEPRRPRK-SIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTT------RSRTLPEPT 304
|
330 340 350
....*....|....*....|....*....|.
gi 1172515803 319 RDSRDIIAAAVNALDRIWVPGHRYAKAGVML 349
Cdd:COG0389 305 DDTAELLRAARELLERIYRPGRPVRLLGVRL 335
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
6-336 |
4.16e-56 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 188.11 E-value: 4.16e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPVICLSNNDGCVIAR-SPEAkRRLGIKMGTPWFQLKDVqFPEKLFVfSSNYELYASLSNR 84
Cdd:cd03586 4 DMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVSTaSYEA-RKFGVRSAMPIFQAKKL-CPNLIFV-PPRFDKYREVSRQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 85 VVALLEELSPRVEQYSIDECFLDARGIGHC-MDLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKewPqfRGV 163
Cdd:cd03586 81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLfGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNK--P--NGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 164 LALSPDNpgrTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKNFNVVLERTVRELNGESCISLEEAP 243
Cdd:cd03586 157 TVIPPED---VEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 244 PPKqQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAVKEPyygnisTEKLSTPTRDSRD 323
Cdd:cd03586 234 ERK-SIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTR------SRTLPEPTDDAED 306
|
330
....*....|...
gi 1172515803 324 IIAAAVNALDRIW 336
Cdd:cd03586 307 IYELALELLEELL 319
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
4-384 |
2.59e-49 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 172.49 E-value: 2.59e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 4 LADVNSFYASCEKVFRPDLRGKPVICL---SNNDGCVIARSPEAKRRlGIKMGTPWFQLKDvQFPEkLFVFSSNYELYAS 80
Cdd:PRK03103 7 LVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAY-GVKTAERLWEAQQ-KCPD-LVVVKPRMQRYID 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 81 LSNRVVALLEELSPRVEQYSIDECFLDARGIGHCM-DLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSA--QWASKEw 157
Cdd:PRK03103 84 VSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFgSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMAcdNFAKKN- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 158 PQfrGVLALSPDNpgRTAKLLSLqPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKNFNVVLERTVRELNGesci 237
Cdd:PRK03103 163 PD--GLFTLDKED--VPADLWPL-PVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANG---- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 238 sLEEAPPPKQQIVCSRSFGQRIT------TYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAVKEPYYGNIst 311
Cdd:PRK03103 234 -IDYSPVTPHSLDRQKAIGHQMTlprdyrGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTGFSRQM-- 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1172515803 312 eKLSTPTRDSRDIIAAAVNALDRIWvPGHRYAKAGVMLNDFCPNGVSQLNLFDEiqpRPHSDALMKVLDGINH 384
Cdd:PRK03103 311 -TLPEPTNLAMEVYEAACKLFHRHW-DGKPVRRVGVTLSNLVSDDVWQLSLFGD---RERKRSLGYVMDDIKN 378
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-350 |
3.75e-47 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 164.84 E-value: 3.75e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPVICLSNND--GCVIARSPEAkRRLGIKMGTPWFQLKDVqFPEkLFVFSSNYELYASLSN 83
Cdd:cd00424 4 DFDNFFASVEQLARPELKGRPVVVVPFNSdsTCVIACSYEA-RKYGVKRGMPVREARKM-CPN-LILVPARLDLYRRLSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 84 RVVALLEELSPRVEQYSIDECFLDARGIGHCM-DLEEFGRQLRGHVLSGTG-LTIGVGFGATKTLAKSAQWASKewPQfr 161
Cdd:cd00424 81 RLLSELEEVAPLVEVASIDELFLDLTGSARLLgLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAK--PD-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 162 GVLALSPDN-PGRTAKLlslqPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKN-FNVVLERTVRELNGESCISL 239
Cdd:cd00424 157 GLTILDPEDlPGFLSKL----PLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALwGGVSGERLWYALRGIDDEPL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 240 EEaPPPKQQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKT--SPFAVKEPYYGNISTEKLSTP 317
Cdd:cd00424 233 SP-PRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTvdGRWSGHADIPSRSAPRPISTE 311
|
330 340 350
....*....|....*....|....*....|...
gi 1172515803 318 TRDSRDIIAAAVNALDRIWvPGHRYAKAGVMLN 350
Cdd:cd00424 312 DGELLHALDKLWRALLDDK-GPRRLRRLGVRLS 343
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
6-150 |
2.19e-39 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 138.09 E-value: 2.19e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPVICLSNN-DGCVIARSPEAkRRLGIKMGTPWFQLKDVqFPEkLFVFSSNYELYASLSNR 84
Cdd:pfam00817 2 DMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEA-RKYGVRSGMPVFEAKKL-CPN-LIVVPPDLELYRRASRK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1172515803 85 VVALLEEL-SPRVEQYSIDECFLDARGIGHCMDLEE-FGRQLRGHVLSGTGLTIGVGFGATKTLAKSA 150
Cdd:pfam00817 79 IFEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEEaLAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
6-335 |
3.96e-38 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 140.93 E-value: 3.96e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPVICLSNND-----GCVIARSPEAkRRLGIKMGTPwFQLKDVQFPEKLFVfSSNYELYAS 80
Cdd:PRK03352 11 DLDQFIAAVELLRRPELAGLPVIVGGNGDpteprKVVTCASYEA-RAFGVRAGMP-LRTAARRCPDAVFL-PSDPAAYDA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 81 LSNRVVALLEELSPRVEQYSIDECFLDARgighCMDLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKEwpqf 160
Cdd:PRK03352 88 ASEEVMATLRDLGVPVEVWGWDEAFLGVD----TDDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKP---- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 161 RGVLALSPDNpgrTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKNFN-------VVLERTVrelnG 233
Cdd:PRK03352 160 AGVFRLTDAN---WMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpttgpwlLLLARGG----G 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 234 ESCISlEEAPPPKqqivcSRS----FGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFavkepyYGNI 309
Cdd:PRK03352 233 DTEVS-AEPWVPR-----SRSrevtFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATF------YTRT 300
|
330 340
....*....|....*....|....*.
gi 1172515803 310 STEKLSTPTRDSRDIIAAAVNALDRI 335
Cdd:PRK03352 301 KIRKLPEPTTDPDVIEAAALDVLDRF 326
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
6-334 |
3.29e-33 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 129.67 E-value: 3.29e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPVIC--LSNNdGCVIARSPEAkRRLGIKMGTPWFQLKDVqFPEKLFVFSSNYELYASLSN 83
Cdd:PRK03348 11 DMDAFFASVEQLTRPTLRGRPVLVggLGGR-GVVAGASYEA-RVFGARSAMPMHQARRL-VGNGAVVLPPRFVVYRAASR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 84 RVVALLEELSPRVEQYSIDECFLDARGIG--HCMDLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKewpqfr 161
Cdd:PRK03348 88 RVFDTLRELSPVVEQLSFDEAFVEPAELAgaSAEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLAK------ 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 162 gvlalsPDN-----PGRTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIrknfnvvlertVRELNGESC 236
Cdd:PRK03348 162 ------PDGirvvpPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEV-----------ANLLGATVG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 237 ISL-------------EEAppPKQQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAVke 303
Cdd:PRK03348 225 PALhrlargiddrpvaERA--EAKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFST-- 300
|
330 340 350
....*....|....*....|....*....|..
gi 1172515803 304 pyygnIS-TEKLSTPTRDSRDIIAAAVNALDR 334
Cdd:PRK03348 301 -----LTrSATLPYATDDAAVLAATARRLLLD 327
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
6-383 |
3.62e-32 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 125.91 E-value: 3.62e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPVICLSN---NDGCVIARSPEAKRRlGIKMGTPWFQLKDvQFPEkLFVFSSNYELYASLS 82
Cdd:PRK01810 11 DMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAY-GIRTTMPLWEAKR-LCPQ-LIVRRPNFDRYREAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 83 NRVVALLEELSPRVEQYSIDECFLDARGIGHCMDLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQwaskEWPQFRG 162
Cdd:PRK01810 88 RQMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMAS----DMKKPLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 163 VLALSP-DNPgrtAKLLSLqPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKNFNVVLERTVRELNGEscislEE 241
Cdd:PRK01810 164 ITVLRKrDVP---EMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGI-----DD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 242 APPPKQQIVCSRSFG------QRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAvkepyygNIS-TEKL 314
Cdd:PRK01810 235 RPVDPEAIYQFKSVGnsttlsHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRR-------TITrSKTL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1172515803 315 STPTRDSRDIIAAAVNALDRIWvPGHRYAKAGVMLNDFC--PNGVSQLNLF---DEIQPRPhsdaLMKVLDGIN 383
Cdd:PRK01810 308 KNPIWEKRDIFQAASRLFKQHW-NGDPVRLLGVTATDLEwkTEAVKQLDLFsfeEDAKEEP----LLAVIDQIN 376
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
5-288 |
3.01e-31 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 123.17 E-value: 3.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 5 ADVNSFYASCEKVFRPDLRGKPVIClsnNDGCVIARSPEAKRRlGIKMGTPWFQLKDVqFPEKLFVfSSNYELYASLSNR 84
Cdd:PRK03858 9 ADLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAY-GVRTAMGGRQARRL-CPQAVVV-PPRMSAYSRASKA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 85 VVALLEELSPRVEQYSIDECFLDARGIGHCMDL-EEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKewPQfrGV 163
Cdd:PRK03858 83 VFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTpVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAK--PD--GL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 164 LALSPDnpGRTAKLLSLqPVEEIWGVGNRIAKKLKAMGITTALQLSLTNptfirknfNVVLERTVRELNGE--SCISLEE 241
Cdd:PRK03858 159 LVVPPD--RELAFLHPL-PVRRLWGVGPVTAAKLRAHGITTVGDVAELP--------ESALVSLLGPAAGRhlHALAHNR 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1172515803 242 APPP------KQQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCR 288
Cdd:PRK03858 228 DPRRvetgrrRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGR 280
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
6-363 |
3.89e-31 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 122.13 E-value: 3.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPVIC--LSNNdGCVIARSPEAkRRLGIKMGTPWFQLKDvQFPEKLFVfSSNYELYASLSN 83
Cdd:PRK14133 9 DMDAFFASVEQMDNPKLKGKPVIVggISER-GVVSTCSYEA-RKYGVHSAMPVFMAKK-RCPHGIFL-PVRHERYKEVSK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 84 RVVALLEELSPRVEQYSIDECFLDARGIGHcmDLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQwaskEWPQFRGV 163
Cdd:PRK14133 85 NIFKILYEVTPIVEPVSIDEAYLDITNIKE--EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLAS----DWNKPDGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 164 LALSPDnpgRTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTA---LQLSLTNPTFIRKNFNVVLERTVRELNGESCISLE 240
Cdd:PRK14133 159 KIITED---MIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIedlLKLSREFLIEYFGKFGVEIYERIRGIDYREVEVSR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 241 EapppKQQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAVkepyygNISTEKLSTPTRD 320
Cdd:PRK14133 236 E----RKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQT------HTKSKTLNDYIRD 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1172515803 321 SRDIIAAAVNALDRIWVpgHRYAK-AGVMLNDFCPNGVSQLNLF 363
Cdd:PRK14133 306 KEEIYNVACEILEHINI--KEPIRlIGLSVSNLSENKIEQLSFL 347
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
246-356 |
8.84e-27 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 103.02 E-value: 8.84e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 246 KQQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFavkepyyGNIS-TEKLSTPTRDSRDI 324
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDF-------RTITrSVTLPSPTDDTDEI 73
|
90 100 110
....*....|....*....|....*....|..
gi 1172515803 325 IAAAVNALDRIWvPGHRYAKAGVMLNDFCPNG 356
Cdd:pfam11799 74 YRAALRLLRRLY-RGRPVRLLGVSLSNLVPEG 104
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
1-202 |
7.23e-23 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 98.71 E-value: 7.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 1 MFALADVNSFYASCEKVFRPDLRGKPVI-CL---SNNDGCVIARSPEAKRRLGIKMGTPWFQLKDVqFPEKLFVfSSNYE 76
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVvCVysgRFEDSGAVATANYEARKLGIKAGMPIVEAKKI-LPNAVYL-PMRKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 77 LYASLSNRVVALLEELSPRVEQYSIDECFLD-ARGIGHCMDLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAqwASK 155
Cdd:PRK01216 80 VYQQVSNRIMKLLREYSEKIEIASIDEAYLDiSDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIA--ADM 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1172515803 156 EWPQfrGVLALSPDNPGRTAKLLSlqpVEEIWGVGNRIAKKLKAMGI 202
Cdd:PRK01216 158 AKPN--GIKVIDDEEVKRFINELD---IADIPGIGDITAEKLKKLGV 199
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
6-354 |
4.44e-22 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 97.31 E-value: 4.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPVICLSNNDG-----CVIARspeakrRLGIKMGTPWFQ-LKDVqfPEKLfVFSSNYELYA 79
Cdd:PRK02794 42 DCDAFYASVEKRDNPELRDKPVIIGGGKRGvvstaCYIAR------IHGVRSAMPMFKaLKLC--PDAV-VIKPDMEKYV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 80 SLSNRVVALLEELSPRVEQYSIDECFLDARGIG--HCMD----LEEFGRQLRGHVlsgtGLTIGVGFGATKTLAKSAQWA 153
Cdd:PRK02794 113 RVGREVRAMMQALTPLVEPLSIDEAFLDLSGTErlHGAPpavvLARFARRVEREI----GITVSVGLSYNKFLAKIASDL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 154 SKewPqfRGVLALSPDNpgrTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKNFNVVLERTVRELNG 233
Cdd:PRK02794 189 DK--P--RGFSVIGRAE---ALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 234 ESCISLEEAPPPKqQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAVKepyygnISTEK 313
Cdd:PRK02794 262 IDDRKVSPDREAK-SVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLR------TRRRT 334
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1172515803 314 LSTPTRDSRDIIAAAVNALDRIwVPGHRYAKAGVMLNDFCP 354
Cdd:PRK02794 335 LEDPTQLADRIFRTARELLEKE-TDGTAFRLIGIGVSDLSP 374
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
375-422 |
5.65e-21 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 85.23 E-value: 5.65e-21
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1172515803 375 LMKVLDGINHS-GLGKIWFAGRGIAPEWQMKRDMLSPAYTTRWKELPVA 422
Cdd:pfam13438 1 LMAALDAINRRyGRGTVRLAAQGLKRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
6-332 |
8.52e-21 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 93.53 E-value: 8.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPV-ICLSNNDGCVIARSPEAKRRLGIKMGTpWF-QLKDVqFPEkLFVFSSNYELYASLSN 83
Cdd:cd01701 53 DFDCFFVSVSIRNRPDLKGKPVaVCHGKGPNSEIASCNYEARSYGIKNGM-WVgQAKKL-CPQ-LVTLPYDFEAYEEVSL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 84 RVVALLEELSPRVEQYSIDECFLDARGIGHCM--DLEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKewPQfr 161
Cdd:cd01701 130 TFYEILASYTDNIEAVSCDEALIDITSLLEETyeLPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAK--PD-- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 162 GVLALSPDNpgrTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRknfnvvLERTVRELNGESCISL-- 239
Cdd:cd01701 206 GQYHLSAEK---VEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRSKTKEK------LQKVLGPKTGEKLYDYcr 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 240 ------EEAPPPKQQIVCSRSFGQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKT-SPFAVKEP--YYG--- 307
Cdd:cd01701 277 giddrpVTGEKERKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGRQITLKLMKrAPGAPIEPpkYMGhgi 356
|
330 340
....*....|....*....|....*...
gi 1172515803 308 --NIS-TEKLSTPTRDSRdIIAAAVNAL 332
Cdd:cd01701 357 cdSFSkSSTLGVATDDSG-VIGTEAKKL 383
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
10-363 |
1.38e-10 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 62.44 E-value: 1.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 10 FYASCEKVFRPDLRGKPVICLSNND--GCVIARSPEAkRRLGIK--MGTpWFQLKdvQFPEKLFVfSSNYELYASLSNRV 85
Cdd:PRK02406 4 FYAAVEMRDNPELRGKPVAVGGSPGrrGVISTCNYEA-RKFGVRsaMPT-AQALK--LCPDLIFV-PGRFDVYKEVSRQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 86 VALLEELSPRVEQYSIDECFLDARGIGHCMdleefG------RQLRGHVLSGTGLTIGVGFGATKTLAKSaqwASkEW-- 157
Cdd:PRK02406 79 REIFRRYTDLIEPLSLDEAYLDVTDNKLCI-----GsatliaQEIRQDIFEELGLTASAGVAPNKFLAKI---AS-DWnk 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 158 P--QFrgVlaLSPDNPgrTAKLLSLqPVEEIWGVGNRIAKKLKAMGITTALQLSLTNPTFIRKNFNV---VL-------- 224
Cdd:PRK02406 150 PngLF--V--ITPEEV--DAFLATL-PVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKfgrRLyerargid 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 225 ERTV---RELngEScISLEeapppkqqivcsRSFGQRITTYDELRQAICQ-------YAERAAEKLRGERQYCRhisafI 294
Cdd:PRK02406 223 ERPVkpdRER--KS-VGVE------------RTFAEDLYDLEACLAELPRlaeklerRLERAKPDKRIKTVGVK-----L 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1172515803 295 KTSPFAVkepyygnISTEKLSTPTRDSRDIIAAAVNALDRIWVPGHRYAKAGVMLndFCPNGVSQLNLF 363
Cdd:PRK02406 283 KFADFQQ-------TTKEHTADPLDKADLIELLAQALLRRLGGRGVRLLGVGVTL--LEPQLERQLLLD 342
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
3-261 |
4.35e-09 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 57.71 E-value: 4.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 3 ALADVNSFYASCEKVFRPDLRGKPVICLSNNDgcVIARSPEAkRRLGIKMGT------------------PWFQLKDVQF 64
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNS--IIAVSYAA-RAFGVTRFMtideakkkcpdlilahvaTYKKGEDEAD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 65 PEKLFVFSS---NYELYASLSNRVVALLEELSPRVEQYSIDECFLDargIGHCMDLEefgrqLRGHVLSGTGLTIGVGFG 141
Cdd:cd01702 78 YHENPSPARhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYLD---LGSRIVEE-----IRQQVYDELGYTCSAGIA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 142 ATKTLAKSAQWASKewpqfrgvlalsPDN-----PGRTAKLLSLQPVEEIWGVGNRIAKKLKA-MGITTALQLSLTN--P 213
Cdd:cd01702 150 HNKMLAKLASGMNK------------PNAqtilrNDAVASFLSSLPITSIRGLGGKLGEEIIDlLGLPTEGDVAGFRssE 217
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1172515803 214 TFIRKNFNVVLERTV-RELNGESCISLEEAPPPKqQIVCSRSFGQRITT 261
Cdd:cd01702 218 SDLQEHFGEKLGEWLyNLLRGIDHEPVKPRPLPK-SMGSSKNFPGKTAL 265
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
6-256 |
2.87e-08 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 55.17 E-value: 2.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPVICLSNNdgcVIARSPEAKRRLGIK--MgtpwfQLKDVQ--FPEKLFVFSSNYELYASL 81
Cdd:cd01703 4 DLDCFYAQVEEIRDPSLKSKPLGIQQKY---IVVTCNYEARRLGVKklM-----SIKDAKeiCPDLVLVNGEDLTPFRDM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 82 SNRVVALLEELSP--RVEQYSIDECFLDARGighcMDL---EEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKE 156
Cdd:cd01703 76 SKKVYRLLRSYSWndRVERLGFDENFMDVTE----MRLlvaSHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 157 WPQfrgvLALSPDNPGRTAKLLSLQPVEEIWGVGNRIAKKLKAMGITTA--LQLSLTNPTFIRKNFNVVLE--------- 225
Cdd:cd01703 152 NQQ----TTLLPPSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVrdLQEFSNRNRQTVGAAPSLLElllmvkefg 227
|
250 260 270
....*....|....*....|....*....|....*.
gi 1172515803 226 -----RTVRELNGESCISLEEAPPPKQQIVCSRSFG 256
Cdd:cd01703 228 egigqRIWKLLFGRDTSPVKPASDFPQQISIEDSYK 263
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
6-369 |
1.73e-07 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 53.48 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 6 DVNSFYASCEKVFRPDLRGKPvicLSNNDGCVIARSPEAKRRLGIKMGTPWFQlkDVQFPEKLFVFSSNYELYASLSNRV 85
Cdd:PTZ00205 139 DMDMFYAAVEIKKHPEYAAIP---LAIGTMTMLQTANYVARGRGIRQGMPGFL--ALKICPNLLILPPDFDAYNEESNTV 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 86 VALLEELSPRVEQYSIDECFLDARGIGHCMD----LEEFGRQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKewPQFR 161
Cdd:PTZ00205 214 RRIVAEYDPNYISFGLDELTLEVSAYIERFEgtktAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINK--PNGQ 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 162 GVLALSPDNPGRT-AKLLSLQPVEeiwGVGNRIAKKLKAMGITT---------ALQLSLTNPTF---IRKNFNVV-LERT 227
Cdd:PTZ00205 292 HDLNLHTRGDVMTyVRDLGLRSVP---GVGKVTEALLKGLGITTlsdiynrrvELCYILHNNLFrflLGASIGIMqWPDA 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172515803 228 VRELNGESCislEEAP-PPKQQIVCSRSFgQRITTYDELRQAICQYAERAAEKLRGERQYCRHISAFIKTSPFAVKEpyy 306
Cdd:PTZ00205 369 ATAANTENC---EGATgGQRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQQ--- 441
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1172515803 307 gniSTEKLSTPTRDSrdiiAAAVNALDRIWVP-GHRYAKA---GVMLNDFCP--------NGVSQLNLFDEIQPR 369
Cdd:PTZ00205 442 ---YTKSLIQYSDDS----ATLRRAVDGLLLPhAAKYSEMcllGVRFLDLISakdfhmkrKGGNQLSISQFIRPK 509
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
171-202 |
6.06e-04 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 36.99 E-value: 6.06e-04
10 20 30
....*....|....*....|....*....|..
gi 1172515803 171 PGRTAKLLSLQPVEEIWGVGNRIAKKLKAMGI 202
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| H3TH |
COG3743 |
Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain ... |
186-218 |
9.68e-03 |
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Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain [Replication, recombination and repair];
Pssm-ID: 442957 [Multi-domain] Cd Length: 92 Bit Score: 35.29 E-value: 9.68e-03
10 20 30
....*....|....*....|....*....|...
gi 1172515803 186 IWGVGNRIAKKLKAMGITTALQLSLTNPTFIRK 218
Cdd:COG3743 28 IKGIGPKIEKKLNELGIFTFAQIAAWTPEDIAW 60
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