NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1169554|sp|P45439|]
View 

RecName: Full=rRNA adenine N-6-methyltransferase; AltName: Full=Erythromycin resistance protein; AltName: Full=Macrolide-lincosamide-streptogramin B resistance protein

Protein Classification

ribosomal RNA small subunit methyltransferase A( domain architecture ID 10000482)

ribosomal RNA small subunit methyltransferase A specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.1.182
Gene Ontology:  GO:1904047|GO:0052908|GO:0031167
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 58-310 3.49e-67

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 211.14  E-value: 3.49e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   58 RARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFggPHHAHVRI 137
Cdd:COG0030  10 RPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETF--AAYPNLTV 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554  138 SGGDFLAAPVPR----EPFALAGNIPYSRTAGIVDWALRAR-TLTSATFVTQLEYARKRTGDYGR--WSLLTVRTWPRHE 210
Cdd:COG0030  88 IEGDALKVDLPAlaagEPLKVVGNLPYNISTPILFKLLEARpPIEDAVLMVQKEVAERLVAKPGSkdYGRLSVLVQYYAD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554  211 WRLLGRVSRREFRPVPRVDSGILRIERRERPLLPSAALGDYHRMVELGFSGVGGSLYASLRRAHRAGPLDAAFRAARLDR 290
Cdd:COG0030 168 VEILFTVPPEAFYPPPKVDSAVVRLTPRPEPLVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEALEAAGIDP 247

                       250       260
                ....*....|....*....|
gi 1169554  291 SVVVAYVTPEQWLTVFRTLR 310
Cdd:COG0030 248 TARAEELSVEEFARLANALK 267
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 58-310 3.49e-67

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 211.14  E-value: 3.49e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   58 RARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFggPHHAHVRI 137
Cdd:COG0030  10 RPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETF--AAYPNLTV 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554  138 SGGDFLAAPVPR----EPFALAGNIPYSRTAGIVDWALRAR-TLTSATFVTQLEYARKRTGDYGR--WSLLTVRTWPRHE 210
Cdd:COG0030  88 IEGDALKVDLPAlaagEPLKVVGNLPYNISTPILFKLLEARpPIEDAVLMVQKEVAERLVAKPGSkdYGRLSVLVQYYAD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554  211 WRLLGRVSRREFRPVPRVDSGILRIERRERPLLPSAALGDYHRMVELGFSGVGGSLYASLRRAHRAGPLDAAFRAARLDR 290
Cdd:COG0030 168 VEILFTVPPEAFYPPPKVDSAVVRLTPRPEPLVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEALEAAGIDP 247

                       250       260
                ....*....|....*....|
gi 1169554  291 SVVVAYVTPEQWLTVFRTLR 310
Cdd:COG0030 248 TARAEELSVEEFARLANALK 267
rADc smart00650
Ribosomal RNA adenine dimethylases;
73-239 3.11e-59

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 187.33  E-value: 3.11e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554      73 VAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFggPHHAHVRISGGDFLAAPVPRE-P 151
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKF--AAADNLTVIHGDALKFDLPKLqP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554     152 FALAGNIPYSRTAGIVDWALRARTL-TSATFVTQLEYARKRTGDYG--RWSLLTVRTWPRHEWRLLGRVSRREFRPVPRV 228
Cdd:smart00650  79 YKVVGNLPYNISTPILFKLLEEPPAfRDAVLMVQKEVARRLAAKPGskDYGRLSVLLQPYADVKILFKVPPSAFRPPPKV 158

                          170
                   ....*....|.
gi 1169554     229 DSGILRIERRE 239
Cdd:smart00650 159 DSAVVRLERRP 169
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
57-306 4.91e-43

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 149.05  E-value: 4.91e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554     57 DRARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFGGphHAHVR 136
Cdd:pfam00398   2 NKFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSL--DENLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    137 ISGGDFLAAPVP------REPFALAGNIPYSRTAGIVDWALRART--LTSATFVTQLEYARKRTGDYG--RWSLLTVRTW 206
Cdd:pfam00398  80 VIHQDFLKFEFPslvthiHQEFLVVGNLPYNISTPIVKQLLFESRfgIVDMLLMLQKEFARRLLARPGskLYSRLSVLRQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    207 PRHEWRLLGRVSRREFRPVPRVDSGILRIERRERPLLPSAALGDYHRMVELGFSGVGGSLYASLRRAHRAGPLDaAFRAA 286
Cdd:pfam00398 160 AFTDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQLQ-AFSSH 238

                         250       260
                  ....*....|....*....|
gi 1169554    287 RLDRSVVVAYVTPEQWLTVF 306
Cdd:pfam00398 239 GINDNALVKKLSPEQTLDIF 258
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 58-309 1.87e-35

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 128.89  E-value: 1.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554     58 RARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFGGPHhaHVRI 137
Cdd:TIGR00755   2 RPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYN--NLEI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    138 SGGDFLAAPVPR---EPFALAGNIPYSRTAGIVdWAL--RARTLTSATFVTQLEYARK-----RTGDYGRWSLLtVRTWp 207
Cdd:TIGR00755  80 IEGDALKFDLNElakDLTKVVGNLPYNISSPLI-FKLlkEKDAFKLAVLMVQKEVAERlvakpGSKDYGRLSVL-VQYY- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    208 rHEWRLLGRVSRREFRPVPRVDSGILRIERRERPLLPSaALGDYHRMVELGFSGVGGSLYASLRRAhrAGPLDAAFRAAR 287
Cdd:TIGR00755 157 -ANVEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPK-DFALFEELLKAAFQQRRKTLRNNLKNL--LSELVELLEELG 232

                         250       260
                  ....*....|....*....|..
gi 1169554    288 LDRSVVVAYVTPEQWLTVFRTL 309
Cdd:TIGR00755 233 IDPDKRVEQLSPEDFLRLANLL 254
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
58-241 7.19e-27

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 106.14  E-value: 7.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    58 RARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFggPHHAHVRI 137
Cdd:PRK14896   2 RMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDE--IAAGNVEI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   138 SGGDFLAAPVPREPFALAgNIPYSRTAGIVDWALRARTLTsATFVTQLEYARK-----RTGDYGRwslLTVRTWPRHEWR 212
Cdd:PRK14896  80 IEGDALKVDLPEFNKVVS-NLPYQISSPITFKLLKHGFEP-AVLMYQKEFAERmvakpGTKEYGR---LSVMVQYYADVE 154

                        170       180
                 ....*....|....*....|....*....
gi 1169554   213 LLGRVSRREFRPVPRVDSGILRIERRERP 241
Cdd:PRK14896 155 IVEKVPPGAFSPKPKVDSAVVRLTPREPK 183
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 58-310 3.49e-67

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 211.14  E-value: 3.49e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   58 RARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFggPHHAHVRI 137
Cdd:COG0030  10 RPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETF--AAYPNLTV 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554  138 SGGDFLAAPVPR----EPFALAGNIPYSRTAGIVDWALRAR-TLTSATFVTQLEYARKRTGDYGR--WSLLTVRTWPRHE 210
Cdd:COG0030  88 IEGDALKVDLPAlaagEPLKVVGNLPYNISTPILFKLLEARpPIEDAVLMVQKEVAERLVAKPGSkdYGRLSVLVQYYAD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554  211 WRLLGRVSRREFRPVPRVDSGILRIERRERPLLPSAALGDYHRMVELGFSGVGGSLYASLRRAHRAGPLDAAFRAARLDR 290
Cdd:COG0030 168 VEILFTVPPEAFYPPPKVDSAVVRLTPRPEPLVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEALEAAGIDP 247

                       250       260
                ....*....|....*....|
gi 1169554  291 SVVVAYVTPEQWLTVFRTLR 310
Cdd:COG0030 248 TARAEELSVEEFARLANALK 267
rADc smart00650
Ribosomal RNA adenine dimethylases;
73-239 3.11e-59

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 187.33  E-value: 3.11e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554      73 VAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFggPHHAHVRISGGDFLAAPVPRE-P 151
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKF--AAADNLTVIHGDALKFDLPKLqP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554     152 FALAGNIPYSRTAGIVDWALRARTL-TSATFVTQLEYARKRTGDYG--RWSLLTVRTWPRHEWRLLGRVSRREFRPVPRV 228
Cdd:smart00650  79 YKVVGNLPYNISTPILFKLLEEPPAfRDAVLMVQKEVARRLAAKPGskDYGRLSVLLQPYADVKILFKVPPSAFRPPPKV 158

                          170
                   ....*....|.
gi 1169554     229 DSGILRIERRE 239
Cdd:smart00650 159 DSAVVRLERRP 169
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
57-306 4.91e-43

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 149.05  E-value: 4.91e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554     57 DRARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFGGphHAHVR 136
Cdd:pfam00398   2 NKFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSL--DENLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    137 ISGGDFLAAPVP------REPFALAGNIPYSRTAGIVDWALRART--LTSATFVTQLEYARKRTGDYG--RWSLLTVRTW 206
Cdd:pfam00398  80 VIHQDFLKFEFPslvthiHQEFLVVGNLPYNISTPIVKQLLFESRfgIVDMLLMLQKEFARRLLARPGskLYSRLSVLRQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    207 PRHEWRLLGRVSRREFRPVPRVDSGILRIERRERPLLPSAALGDYHRMVELGFSGVGGSLYASLRRAHRAGPLDaAFRAA 286
Cdd:pfam00398 160 AFTDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQLQ-AFSSH 238

                         250       260
                  ....*....|....*....|
gi 1169554    287 RLDRSVVVAYVTPEQWLTVF 306
Cdd:pfam00398 239 GINDNALVKKLSPEQTLDIF 258
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 58-309 1.87e-35

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 128.89  E-value: 1.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554     58 RARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFGGPHhaHVRI 137
Cdd:TIGR00755   2 RPRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYN--NLEI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    138 SGGDFLAAPVPR---EPFALAGNIPYSRTAGIVdWAL--RARTLTSATFVTQLEYARK-----RTGDYGRWSLLtVRTWp 207
Cdd:TIGR00755  80 IEGDALKFDLNElakDLTKVVGNLPYNISSPLI-FKLlkEKDAFKLAVLMVQKEVAERlvakpGSKDYGRLSVL-VQYY- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    208 rHEWRLLGRVSRREFRPVPRVDSGILRIERRERPLLPSaALGDYHRMVELGFSGVGGSLYASLRRAhrAGPLDAAFRAAR 287
Cdd:TIGR00755 157 -ANVEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPK-DFALFEELLKAAFQQRRKTLRNNLKNL--LSELVELLEELG 232

                         250       260
                  ....*....|....*....|..
gi 1169554    288 LDRSVVVAYVTPEQWLTVFRTL 309
Cdd:TIGR00755 233 IDPDKRVEQLSPEDFLRLANLL 254
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
58-241 7.19e-27

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 106.14  E-value: 7.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    58 RARRELSQNFLARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFggPHHAHVRI 137
Cdd:PRK14896   2 RMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDE--IAAGNVEI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   138 SGGDFLAAPVPREPFALAgNIPYSRTAGIVDWALRARTLTsATFVTQLEYARK-----RTGDYGRwslLTVRTWPRHEWR 212
Cdd:PRK14896  80 IEGDALKVDLPEFNKVVS-NLPYQISSPITFKLLKHGFEP-AVLMYQKEFAERmvakpGTKEYGR---LSVMVQYYADVE 154

                        170       180
                 ....*....|....*....|....*....
gi 1169554   213 LLGRVSRREFRPVPRVDSGILRIERRERP 241
Cdd:PRK14896 155 IVEKVPPGAFSPKPKVDSAVVRLTPREPK 183
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 90-242 3.46e-17

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 80.05  E-value: 3.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554    90 LEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRF-GGPHHAHVRISGGDFLAAPVPrePFAL-AGNIPYSRTAGIV 167
Cdd:PTZ00338  41 LEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELKKRFqNSPLASKLEVIEGDALKTEFP--YFDVcVANVPYQISSPLV 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   168 DWALRARTL-TSATFVTQLEYARK---RTGD--YGRwslLTVRTwprhewRLLGR------VSRREFRPVPRVDSGILRI 235
Cdd:PTZ00338 119 FKLLAHRPLfRCAVLMFQKEFALRllaQPGDelYCR---LSVNT------QLLCRvthlmkVSKNSFNPPPKVESSVVRI 189


                 ....*..
gi 1169554   236 ERRERPL 242
Cdd:PTZ00338 190 EPKNPPP 196
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 69-152 9.78e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 9.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   69 ARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFgGPHHAHVRISGGDFLAAPVP 148
Cdd:COG2226   6 ARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERA-AEAGLNVEFVVGDAEDLPFP 84


                ....
gi 1169554  149 REPF 152
Cdd:COG2226  85 DGSF 88
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
73-155 9.78e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 45.37  E-value: 9.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   73 VAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRfggphHAHVRISGGDFLAAPVPREPF 152
Cdd:COG4976  34 LAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREK-----GVYDRLLVADLADLAEPDGRF 108


                ...
gi 1169554  153 ALA 155
Cdd:COG4976 109 DLI 111
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 69-152 5.94e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 41.93  E-value: 5.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   69 ARRAVAERVARLVRP--APGGLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFggpHHAHVRISGGDFLAAP 146
Cdd:COG2227   6 ARDFWDRRLAALLARllPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERA---AELNVDFVQGDLEDLP 82


                ....*.
gi 1169554  147 VPREPF 152
Cdd:COG2227  83 LEDGSF 88
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 90-152 5.86e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 38.31  E-value: 5.86e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1169554     90 LEVGAGRGVLTEALAPYCG-RLVAHEIDPRLLPALRDRFGGpHHAHVRISGGDFLAAPVPREPF 152
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGaRVTGVDLSPEMLERARERAAE-AGLNVEFVQGDAEDLPFPDGSF 64
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 90-152 6.55e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.41  E-value: 6.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169554     90 LEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFGGPHHAHVRisgGDFLAAPVPREPF 152
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVV---GDAEDLPFPDNSF 60
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 72-155 6.09e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 37.20  E-value: 6.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   72 AVAERVARLVRPAPGGLLLEVGAGRGVLTEALA-PYCGRLVAHEIDPRLLPALRDRFGGPHHAHVRISGGDFLA-APVPR 149
Cdd:COG0500  13 GLAALLALLERLPKGGRVLDLGCGTGRNLLALAaRFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAElDPLPA 92


                ....*.
gi 1169554  150 EPFALA 155
Cdd:COG0500  93 ESFDLV 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 69-152 6.65e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 36.83  E-value: 6.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169554   69 ARRAVAERVARLVRPAPGGLLLEVGAGRGVLTEALAPYCG-RLVAHEIDPRLLPALRDRF---GGPHHAHVRIsgGDFLA 144
Cdd:COG2230  35 AQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGvRVTGVTLSPEQLEYARERAaeaGLADRVEVRL--ADYRD 112


                ....*...
gi 1169554  145 APvPREPF 152
Cdd:COG2230 113 LP-ADGQF 119
NodS pfam05401
Nodulation protein S (NodS); This family consists of nodulation S (NodS) proteins. The ...
 87-132 6.97e-03

Nodulation protein S (NodS); This family consists of nodulation S (NodS) proteins. The products of the rhizobial nodulation genes are involved in the biosynthesis of lipochitin oligosaccharides (LCOs), which are host-specific signal molecules required for nodule formation. NodS is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase involved in N methylation of LCOs. NodS uses N-deacetylated chitooligosaccharides, the products of the NodBC proteins, as its methyl acceptors.


Pssm-ID: 428457  Cd Length: 201  Bit Score: 37.29  E-value: 6.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1169554     87 GLLLEVGAGRGVLTEALAPYCGRLVAHEIDPRLLPALRDRFGGPHH 132
Cdd:pfam05401  45 ADALEIGCAAGAFTEMLAILCERLTVVDLMPEAIAKAQERTGKWSD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH