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Conserved domains on  [gi|116256449|ref|NP_975011|]
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zinc finger protein 254 isoform b [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 6.52e-33

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 6.52e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116256449    13 LTFRDVAIEFSLEEWQHLDIAQQNLYRNVMLENYRNLAFLGIAVSKPDLITCLEQGKEPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-625 1.35e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 264 KLYKCEECGEAFNRSSNLTTHKIIHTGEKPYKC--EECGKAFIWSSTLTEHKKIHTRKKPYKCE-ECGKAFIWSSTLTRH 340
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 341 KRMHTGEKPYKCEECGKAFSQSSTLT--THKIIHTGEKRYK---------------------CLECGKAFKQLSTLTTHK 397
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 398 IIHVGEKLYKCEECGKgFNRSSNLTTHKIIHTGEKPYKCEECGKAF-----IWSSTLTKHKRIHTREKP-YKCEECGKAF 471
Cdd:COG5048  192 VSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllSQSPSSLSSSDSSSSASEsPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 472 IWSSTLTRHKRMHTG-EKPYKCEECGKSFSQSSTLTTHK--IIHTGE--KPYKCEE--CGKAFNWSSTLTKHKIIHTEEK 544
Cdd:COG5048  271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 545 PYKC--EKCGKAFKQSSI-----LTNHKRIHTGEKPYKCE--ECGKSFNRSSTFTKHKVIHTGVKP--YKCEECGKAFFW 613
Cdd:COG5048  351 PAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410
                 ....*....|..
gi 116256449 614 SSTLTKHKRIHT 625
Cdd:COG5048  431 HYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 6.52e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 6.52e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116256449    13 LTFRDVAIEFSLEEWQHLDIAQQNLYRNVMLENYRNLAFLGIAVSKPDLITCLEQGKEPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 1.06e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 1.06e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 116256449   12 LLTFRDVAIEFSLEEWQHLDIAQQNLYRNVMLENYRNLAFLG 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 2.98e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 2.98e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 116256449  13 LTFRDVAIEFSLEEWQHLDIAQQNLYRNVMLENYRNLAFL 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-625 1.35e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 264 KLYKCEECGEAFNRSSNLTTHKIIHTGEKPYKC--EECGKAFIWSSTLTEHKKIHTRKKPYKCE-ECGKAFIWSSTLTRH 340
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 341 KRMHTGEKPYKCEECGKAFSQSSTLT--THKIIHTGEKRYK---------------------CLECGKAFKQLSTLTTHK 397
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 398 IIHVGEKLYKCEECGKgFNRSSNLTTHKIIHTGEKPYKCEECGKAF-----IWSSTLTKHKRIHTREKP-YKCEECGKAF 471
Cdd:COG5048  192 VSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllSQSPSSLSSSDSSSSASEsPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 472 IWSSTLTRHKRMHTG-EKPYKCEECGKSFSQSSTLTTHK--IIHTGE--KPYKCEE--CGKAFNWSSTLTKHKIIHTEEK 544
Cdd:COG5048  271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 545 PYKC--EKCGKAFKQSSI-----LTNHKRIHTGEKPYKCE--ECGKSFNRSSTFTKHKVIHTGVKP--YKCEECGKAFFW 613
Cdd:COG5048  351 PAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410
                 ....*....|..
gi 116256449 614 SSTLTKHKRIHT 625
Cdd:COG5048  431 HYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-501 4.98e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.98e-05
                          10        20
                  ....*....|....*....|....*
gi 116256449  477 LTRHKRMHTGEKPYKCEECGKSFSQ 501
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 6.52e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 6.52e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116256449    13 LTFRDVAIEFSLEEWQHLDIAQQNLYRNVMLENYRNLAFLGIAVSKPDLITCLEQGKEPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 1.06e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 1.06e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 116256449   12 LLTFRDVAIEFSLEEWQHLDIAQQNLYRNVMLENYRNLAFLG 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 2.98e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 2.98e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 116256449  13 LTFRDVAIEFSLEEWQHLDIAQQNLYRNVMLENYRNLAFL 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-625 1.35e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 264 KLYKCEECGEAFNRSSNLTTHKIIHTGEKPYKC--EECGKAFIWSSTLTEHKKIHTRKKPYKCE-ECGKAFIWSSTLTRH 340
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 341 KRMHTGEKPYKCEECGKAFSQSSTLT--THKIIHTGEKRYK---------------------CLECGKAFKQLSTLTTHK 397
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 398 IIHVGEKLYKCEECGKgFNRSSNLTTHKIIHTGEKPYKCEECGKAF-----IWSSTLTKHKRIHTREKP-YKCEECGKAF 471
Cdd:COG5048  192 VSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllSQSPSSLSSSDSSSSASEsPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 472 IWSSTLTRHKRMHTG-EKPYKCEECGKSFSQSSTLTTHK--IIHTGE--KPYKCEE--CGKAFNWSSTLTKHKIIHTEEK 544
Cdd:COG5048  271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 545 PYKC--EKCGKAFKQSSI-----LTNHKRIHTGEKPYKCE--ECGKSFNRSSTFTKHKVIHTGVKP--YKCEECGKAFFW 613
Cdd:COG5048  351 PAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410
                 ....*....|..
gi 116256449 614 SSTLTKHKRIHT 625
Cdd:COG5048  431 HYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-594 2.41e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 179 KKSFKCKKRVKLFCMLSHKTQHKSIYHREKSYKC--KECGKTFNWSSTLTNHRKIYTEEKPYKCEeyNKSPKQLSTLTTH 256
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 257 EIIHAGEKLYKCE-ECGEAFNRSSNLTTHKIIHTGEKPYKCEECGKAFIWSSTLTEHKKIHTRKKPykcEECGKAFIWSS 335
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 336 TLTRHKRMHTGEKPYKCEECGKAFSQSSTLTTHKIIHTgEKRYKCLECGKAFKQLST----LTTHKIIHVGEKLYKCEEC 411
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLsqspSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 412 G--KGFNRSSNLTTHKIIHTG-EKPYKCEECGKAFIWSSTLTKHKR--IHTRE--KPYKCEE--CGKAFIWSSTLTRHKR 482
Cdd:COG5048  265 LptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 483 MHTGEKPYKC--EECGKSFSQSST-----LTTHKIIHTGEKPYKCE--ECGKAFNWSSTLTKHKIIHTEEKP--YKCEKC 551
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 116256449 552 GKAFKQSSILTNHKRIHTGEKPYKCEECGKSFNRSSTFTKHKV 594
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-609 8.20e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 8.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 222 SSTLTNHRKIYTEEKPYKCEEYNKSPKQLSTLTTHEIIHAGEKLYKC--EECGEAFNRSSNLTTHKIIHTGEKPYKCE-E 298
Cdd:COG5048   18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 299 CGKAFIWSSTLTEHKKIHTRKKPYKCEECGKAFIWSSTLTRHKRMHTGEKPYKCEECGKAFSQSST-------------- 364
Cdd:COG5048   98 LPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpansls 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 365 --------LTTHKIIHTGEKRYKCLECGKAFKQLSTLTTHKIIHVGEKLYKCEECG----KGFNRSSNLTTHKIIHTGEK 432
Cdd:COG5048  178 kdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSSLSSSDSSSSA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 433 PYKCEECG--KAFIWSSTLTKHKRIHTR-EKPYKCEECGKAFIWSSTLTRHKRM--HTGE--KPYKCEE--CGKSFSQSS 503
Cdd:COG5048  258 SESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRND 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 504 TLTTHKIIHTGEKPYKCEEC-------GKAFNWSSTLTKHKIIHTEEKPYKCE--KCGKAFKQSSILTNHKRIHTGEKP- 573
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPy 417

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 116256449 574 -YKCEECGKSFNRSSTFTKHKVIHTGVKPYKCEECGK 609
Cdd:COG5048  418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
319-650 2.76e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 319 KKPYKCEECGKAFIWSSTLTRHKRMHTGEKPYKC--EECGKAFSQSSTLTTHKIIHTGEKRYkcLECGKAFKQLSTLTTH 396
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 397 KIIHVGEKLYKCE-ECGKGFNRSSNLTTHKIIHTGEKPYKCEEcgKAFIWSSTLTKH--KRIHTREKPykcEECGKAFIW 473
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPAN---SLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 474 SSTLTRHKRMHTGEKPYKCEECGKSFSQSSTLTTHKIIHTgEKPYKCEECGKAFN-----WSSTLTKHKIIHTEEKP-YK 547
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPksllsQSPSSLSSSDSSSSASEsPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 548 CEKCGKAFKQSSILTNHKRIHTG-EKPYKCEECGKSFNRSSTFTKHK--VIHTG--VKPYKCEE--CGKAFFWSSTLTKH 620
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 116256449 621 KRIHTGEQPYKW------EKFGKAFNRSSHLTTDKI 650
Cdd:COG5048  343 ILLHTSISPAKEkllnssSKFSPLLNNEPPQSLQQY 378
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
292-644 6.29e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 292 KPYKCEECGKAFIWSSTLTEHKKIHTRKKPYKC--EECGKAFIWSSTLTRHKRMHTGEKPYkcEECGKAFSQSSTLTTHK 369
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 370 IIHTGEKR-YKCLECGKAFKQLSTLTTHKIIHVGEKLYKCEECGKGFNRSSNLTTHKIIHTGEKPykcEECGKAFIWSST 448
Cdd:COG5048  110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 449 LTKHKRIHTREKPYKCEECGKAFIWSSTLTRHKRMHTgEKPYKCEECGKSFSQSSTLTTHKIIHTGEKPYKCEECGKAFN 528
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 529 WSSTLTKHKIIHTEE-------KPYKCEKCGKAFKQSSILTNHKR--IHTGE--KPYKCEE--CGKSFNRSSTFTKHKVI 595
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116256449 596 HTGVKPYKCeecgkafFWSSTLTKHKRIHTGE-----QPYKWEKFGKAFNRSSH 644
Cdd:COG5048  346 HTSISPAKE-------KLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSN 392
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 445-565 5.72e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.33  E-value: 5.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 445 WSSTLTKHKRIHTREKPYKCEECGKAFIWSSTL---TRHKRMHT-GEKPYKCE--ECGKSFSQSSTLTTHKiihtgekpy 518
Cdd:COG5189  301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM--------- 371

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 116256449 519 KCEECGKAFNWSSTLTKHKIIHTEEKPYKCEKCGKAFKQSSILTNHK 565
Cdd:COG5189  372 LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-501 4.98e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.98e-05
                          10        20
                  ....*....|....*....|....*
gi 116256449  477 LTRHKRMHTGEKPYKCEECGKSFSQ 501
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-361 5.82e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.82e-05
                          10        20
                  ....*....|....*....|....*
gi 116256449  337 LTRHKRMHTGEKPYKCEECGKAFSQ 361
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-585 1.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.97e-04
                          10        20
                  ....*....|....*....|....*
gi 116256449  561 LTNHKRIHTGEKPYKCEECGKSFNR 585
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 305-425 9.22e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256449 305 WSSTLTEHKKIHTRKKPYKCEECGKAFIWSSTL---TRHKRMHT-GEKPYKCE--ECGKAFSQSSTLTTHKIiHTgekry 378
Cdd:COG5189  301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHML-HG----- 374

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 116256449 379 kclECGKAFKQLSTLTTHKIIHVGEKLYKCEECGKGFNRSSNLTTHK 425
Cdd:COG5189  375 ---HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-303 9.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.45e-04
                          10        20
                  ....*....|....*....|....
gi 116256449  280 NLTTHKIIHTGEKPYKCEECGKAF 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-443 9.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.45e-04
                          10        20
                  ....*....|....*....|....
gi 116256449  420 NLTTHKIIHTGEKPYKCEECGKAF 443
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
449-471 1.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.79e-03
                          10        20
                  ....*....|....*....|...
gi 116256449  449 LTKHKRIHTREKPYKCEECGKAF 471
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-528 1.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|....
gi 116256449  505 LTTHKIIHTGEKPYKCEECGKAFN 528
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
533-557 2.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.55e-03
                          10        20
                  ....*....|....*....|....*
gi 116256449  533 LTKHKIIHTEEKPYKCEKCGKAFKQ 557
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-331 5.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.22e-03
                          10        20
                  ....*....|....*....|...
gi 116256449  309 LTEHKKIHTRKKPYKCEECGKAF 331
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-389 5.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.99e-03
                          10        20
                  ....*....|....*....|....*
gi 116256449  365 LTTHKIIHTGEKRYKCLECGKAFKQ 389
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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