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Conserved domains on  [gi|116241236|sp|P30154|]
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RecName: Full=Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; AltName: Full=PP2A subunit A isoform PR65-beta; AltName: Full=PP2A subunit A isoform R1-beta

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein may function as a scaffold, anchoring and/or adaptor protein

CATH:  1.25.10.110
Gene Ontology:  GO:0005515
PubMed:  35552740|10378263
SCOP:  4001283

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
193-364 2.07e-07

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.40  E-value: 2.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 193 VRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVR 272
Cdd:COG1413    1 VRRAAARALGRLGD--------PAAVPALIAALADEDPDVRAAAARA---LGRLGDPRAVPALL-----EALKDPDPEVR 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 273 YMVADrfselqkAMGpKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGEnlpiedretiimNQILPYIKELVSDTNQH 352
Cdd:COG1413   65 AAAAE-------ALG-RIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD------------PAAVPALLEALKDPDWE 124
                        170
                 ....*....|..
gi 116241236 353 VKSALASVIMGL 364
Cdd:COG1413  125 VRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
102-239 5.53e-05

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 5.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 102 LPPLENLATVEETVVRDKAVESLRQIsqeHTPVALEayfvPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAeirqq 181
Cdd:COG1413   18 VPALIAALADEDPDVRAAAARALGRL---GDPRAVP----ALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIA----- 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 116241236 182 frsLCSDDTPMVRRAAASKLGEFAKVleldsvksEIVPLFTSLASDEQDSVRLLAVEA 239
Cdd:COG1413   86 ---ALKDEDPEVRRAAAEALGRLGDP--------AAVPALLEALKDPDWEVRRAAARA 132
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
193-364 2.07e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.40  E-value: 2.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 193 VRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVR 272
Cdd:COG1413    1 VRRAAARALGRLGD--------PAAVPALIAALADEDPDVRAAAARA---LGRLGDPRAVPALL-----EALKDPDPEVR 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 273 YMVADrfselqkAMGpKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGEnlpiedretiimNQILPYIKELVSDTNQH 352
Cdd:COG1413   65 AAAAE-------ALG-RIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD------------PAAVPALLEALKDPDWE 124
                        170
                 ....*....|..
gi 116241236 353 VKSALASVIMGL 364
Cdd:COG1413  125 VRRAAARALGRL 136
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
187-322 7.96e-06

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 49.08  E-value: 7.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 187 SDDTPMVRRAAASKLGEFAKVLE--------LDS----VKSEIV-----------PLFTSLASDEQDSVRLLAVEACVSI 243
Cdd:PRK13800 662 GDGAAAVRRAAAEGLRELVEVLPpapalrdhLGSpdpvVRAAALdvlralragdaALFAAALGDPDHRVRIEAVRALVSV 741
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116241236 244 aqllsqDDLETLVMptlrqAAEDKSWRVRYMVADRFSELQKAMGPKitlndlIPAFQNLLKDCEAEVRAAAAHKVKELG 322
Cdd:PRK13800 742 ------DDVESVAG-----AATDENREVRIAVAKGLATLGAGGAPA------GDAVRALTGDPDPLVRAAALAALAELG 803
HEAT COG1413
HEAT repeat [General function prediction only];
102-239 5.53e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 5.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 102 LPPLENLATVEETVVRDKAVESLRQIsqeHTPVALEayfvPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAeirqq 181
Cdd:COG1413   18 VPALIAALADEDPDVRAAAARALGRL---GDPRAVP----ALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIA----- 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 116241236 182 frsLCSDDTPMVRRAAASKLGEFAKVleldsvksEIVPLFTSLASDEQDSVRLLAVEA 239
Cdd:COG1413   86 ---ALKDEDPEVRRAAAEALGRLGDP--------AAVPALLEALKDPDWEVRRAAARA 132
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
217-316 6.25e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 41.94  E-value: 6.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236  217 IVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDdletlVMPTLRQAAEDKSWRVRYMVAdrfselqKAMGpKITLNDLI 296
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRA---LGRIGDPE-----AVPALLELLKDEDPAVRRAAA-------EALG-KIGDPEAL 64
                          90       100
                  ....*....|....*....|.
gi 116241236  297 PAFQNLLKDCEAE-VRAAAAH 316
Cdd:pfam13646  65 PALLELLRDDDDDvVRAAAAE 85
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
193-364 2.07e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.40  E-value: 2.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 193 VRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVR 272
Cdd:COG1413    1 VRRAAARALGRLGD--------PAAVPALIAALADEDPDVRAAAARA---LGRLGDPRAVPALL-----EALKDPDPEVR 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 273 YMVADrfselqkAMGpKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGEnlpiedretiimNQILPYIKELVSDTNQH 352
Cdd:COG1413   65 AAAAE-------ALG-RIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD------------PAAVPALLEALKDPDWE 124
                        170
                 ....*....|..
gi 116241236 353 VKSALASVIMGL 364
Cdd:COG1413  125 VRRAAARALGRL 136
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
187-322 7.96e-06

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 49.08  E-value: 7.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 187 SDDTPMVRRAAASKLGEFAKVLE--------LDS----VKSEIV-----------PLFTSLASDEQDSVRLLAVEACVSI 243
Cdd:PRK13800 662 GDGAAAVRRAAAEGLRELVEVLPpapalrdhLGSpdpvVRAAALdvlralragdaALFAAALGDPDHRVRIEAVRALVSV 741
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116241236 244 aqllsqDDLETLVMptlrqAAEDKSWRVRYMVADRFSELQKAMGPKitlndlIPAFQNLLKDCEAEVRAAAAHKVKELG 322
Cdd:PRK13800 742 ------DDVESVAG-----AATDENREVRIAVAKGLATLGAGGAPA------GDAVRALTGDPDPLVRAAALAALAELG 803
HEAT COG1413
HEAT repeat [General function prediction only];
102-239 5.53e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 5.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236 102 LPPLENLATVEETVVRDKAVESLRQIsqeHTPVALEayfvPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAeirqq 181
Cdd:COG1413   18 VPALIAALADEDPDVRAAAARALGRL---GDPRAVP----ALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIA----- 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 116241236 182 frsLCSDDTPMVRRAAASKLGEFAKVleldsvksEIVPLFTSLASDEQDSVRLLAVEA 239
Cdd:COG1413   86 ---ALKDEDPEVRRAAAEALGRLGDP--------AAVPALLEALKDPDWEVRRAAARA 132
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
217-316 6.25e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 41.94  E-value: 6.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236  217 IVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDdletlVMPTLRQAAEDKSWRVRYMVAdrfselqKAMGpKITLNDLI 296
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRA---LGRIGDPE-----AVPALLELLKDEDPAVRRAAA-------EALG-KIGDPEAL 64
                          90       100
                  ....*....|....*....|.
gi 116241236  297 PAFQNLLKDCEAE-VRAAAAH 316
Cdd:pfam13646  65 PALLELLRDDDDDvVRAAAAE 85
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
185-272 5.25e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241236  185 LCSDDTPMVRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEACVSIAqllSQDDLETLvmptLRQAA 264
Cdd:pfam13646   8 LLRDPDPEVRAAAIRALGRIGD--------PEAVPALLELLKDEDPAVRRAAAEALGKIG---DPEALPAL----LELLR 72

                  ....*...
gi 116241236  265 EDKSWRVR 272
Cdd:pfam13646  73 DDDDDVVR 80
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
191-240 9.36e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 34.65  E-value: 9.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 116241236  191 PMVRRAAASKLGEFAKVLE--LDSVKSEIVPLFTSLASDEQDSVRLLAVEAC 240
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPdlLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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