|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
1081-1216 |
2.83e-41 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 148.63 E-value: 2.83e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 1081 FDAFISYSSKDeaFVAEELAPMLENEDPSYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFKSA 1160
Cdd:smart00255 2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116116753 1161 HHQVLRDRRRRLIVILLGEVPQ--KDLDPDIRLYLKTNtYLQWGDKL---FWEKLRFALPD 1216
Cdd:smart00255 80 LENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVFKKN-YLKWPEDEkeqFWKKALYAVPS 139
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
267-647 |
1.67e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 98.85 E-value: 1.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 267 LNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPATFGVVQAHPTRSFKQQNNEA 346
Cdd:COG4886 2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 347 RAHDLPRSDQRAGVALRKTSSKASAKTFLGLGALHTVILSNNRLCTVDHFtFSGLNSLALLSLDYNRISRIDRqALRNHS 426
Cdd:COG4886 82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 427 ALQELHLNGNKLLQVPDALYDVPLLRTLDLGENHISNIDNAsfrhmahlyglrltennieiirrgtFEAMKSLHILNLSQ 506
Cdd:COG4886 160 NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP-------------------------LGNLTNLEELDLSG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 507 NRLKTVEqASFDNNTKLQAIRLDGNYLTDIAGLfTKLPNLLWLNISDNHLEVFDYALIPTGLQWLDIHANKITELG-NYF 585
Cdd:COG4886 215 NQLTDLP-EPLANLTNLETLDLSNNQLTDLPEL-GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlKEL 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116116753 586 EIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLISKVQSYTFFKKPNLTRVDLFGN 647
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
1084-1190 |
2.61e-20 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 87.76 E-value: 2.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 1084 FISYSSKDEAFVaEELAPMLENEDpsYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFKSAHHq 1163
Cdd:pfam13676 2 FISYAGEDRAWA-EWLADALEAAG--YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA- 77
|
90 100
....*....|....*....|....*..
gi 116116753 1164 vLRDRRRRLIVILLGEvpqKDLDPDIR 1190
Cdd:pfam13676 78 -DPEGRKRLIPVRLEC---DLELPGLA 100
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
37-326 |
2.08e-18 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 89.61 E-value: 2.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 37 WDGYTEDDLTLLCRLRTINSELENTNFSVLHPENTVRLRLQCNDGLFfqsslspgsfkQLTKLHALSIEYCKIANLSEgS 116
Cdd:COG4886 64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-----------NLTNLESLDLSGNQLTDLPE-E 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 117 FQGLKQLVNLTLRthNTDWSSISLDIapqvftSELAKLQRLDLSQNNMWSVPDgFICPLARLSYINLTQNRLRDLSvfhf 196
Cdd:COG4886 132 LANLTNLKELDLS--NNQLTDLPEPL------GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 197 sASLSTRlskkcgSSIVTLDLSHNTIDNLPPAIfSGLGKLTDLRLQSNGLNYIADraFEGLVSLSRLELSLNRLTNLPPE 276
Cdd:COG4886 199 -EPLGNL------TNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 116116753 277 lfSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPA 326
Cdd:COG4886 269 --ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
139-578 |
7.79e-15 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 79.89 E-value: 7.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 139 SLDIAPQVFTSEL-------AKLQRLDLSQNNMWSVPDGFICPLARLSYINLTQNRL-----------RDLSVFHFS-AS 199
Cdd:PLN00113 144 TLDLSNNMLSGEIpndigsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgqiprelgqmKSLKWIYLGyNN 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 200 LSTRLSKKCG--SSIVTLDLSHNtidNLPPAIFSGLGKLTDLR---LQSNGLNYIADRAFEGLVSLSRLELSLNRLTNLP 274
Cdd:PLN00113 224 LSGEIPYEIGglTSLNHLDLVYN---NLTGPIPSSLGNLKNLQylfLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEI 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 275 PELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWinPATFGVVQAHPTRSFKQQNNEARAHD-LPR 353
Cdd:PLN00113 301 PELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI--PKNLGKHNNLTVLDLSTNNLTGEIPEgLCS 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 354 SDQRAGVALRKTSSKASAKTFLGL-GALHTVILSNNRLCTVDHFTFSGLNSLALLSLDYNRIS-RIDRQALrNHSALQEL 431
Cdd:PLN00113 379 SGNLFKLILFSNSLEGEIPKSLGAcRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQML 457
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 432 HLNGNKLL-QVPDaLYDVPLLRTLDLGENHISNIDNASFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLK 510
Cdd:PLN00113 458 SLARNKFFgGLPD-SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116116753 511 TVEQASFDNNTKLQAIRLDGNYLT-DIAGLFTKLPNLLWLNISDNHlevFDYALIPTGlQWLDIHANKI 578
Cdd:PLN00113 537 GQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNH---LHGSLPSTG-AFLAINASAV 601
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
838-897 |
7.12e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.69 E-value: 7.12e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 838 ELEILQLDHNLLTALNGFEFEGLDSLKELFLQYNRIASIANHTFDHLHGLKILRLDHNRL 897
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
259-318 |
1.96e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.84 E-value: 1.96e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 259 SLSRLELSLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNEL 318
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
792-917 |
3.11e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.72 E-value: 3.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 792 TQIYLDGNNFRSLSShAFLGRKRLKILFLNGSNVETVSNrTFYGLKELEILQLDHNLLTALnGFEFEGLDSLKELFLQYN 871
Cdd:COG4886 139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 116116753 872 RIASIANhTFDHLHGLKILRLDHNRLVEFNVWLLPKQLNDIRLAFN 917
Cdd:COG4886 216 QLTDLPE-PLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
431-651 |
9.61e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 57.10 E-value: 9.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 431 LHLNGNKLLQVPDaLYDVPLLRTLDLGENHISNIDN-ASFRHMAHLYglrLTENNIEIIRRgtFEAMKSLHILNLSQNRL 509
Cdd:cd21340 7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIENlEFLTNLTHLY---LQNNQIEKIEN--LENLVNLKKLYLGGNRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 510 KTVEqasfdnntklqairldgnyltdiaGLfTKLPNLLWLNISDNHLevfdyaliPTGLQWLdihankitelgnyFEIES 589
Cdd:cd21340 81 SVVE------------------------GL-ENLTNLEELHIENQRL--------PPGEKLT-------------FDPRS 114
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116116753 590 QLALS----TIDASSNQLTEITGSAIPNSVELLYLNDNLISKVQ--SYTFFKKPNLTRVDLFGNKITT 651
Cdd:cd21340 115 LAALSnslrVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCK 182
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
794-849 |
1.10e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.53 E-value: 1.10e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 116116753 794 IYLDGNNFRSLSSHAFLGRKRLKILFLNGSNVETVSNRTFYGLKELEILQLDHNLL 849
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
210-270 |
4.03e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.99 E-value: 4.03e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116116753 210 SSIVTLDLSHNTIDNLPPAIFSGLGKLTDLRLQSNGLNYIADRAFEGLVSLSRLELSLNRL 270
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
118-321 |
4.35e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 56.59 E-value: 4.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 118 QGLKQLVNLTLRTHNTdwSSISLDiAPQVFTSELAK--LQRLDLSQNNMWSVPDGFIC-----PLARLSYINLTQNRLRD 190
Cdd:cd00116 75 QGLTKGCGLQELDLSD--NALGPD-GCGVLESLLRSssLQELKLNNNGLGDRGLRLLAkglkdLPPALEKLVLGRNRLEG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 191 LSvfhfSASLSTRLSKKCgsSIVTLDLSHNTI-DNLPPAIFSGL---GKLTDLRLQSNGLNYIADRAFEGLV----SLSR 262
Cdd:cd00116 152 AS----CEALAKALRANR--DLKELNLANNGIgDAGIRALAEGLkanCNLEVLDLNNNGLTDEGASALAETLaslkSLEV 225
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116116753 263 LELSLNRLTN-----LPPELFSEAKHIKEIYLQNNSLNVLAPGIFS----DLKQLLVLDLSNNELTSE 321
Cdd:cd00116 226 LNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGEE 293
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
792-897 |
8.80e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 51.33 E-value: 8.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 792 TQIYLDGNNFRSLSSHAFLgrKRLKILFLNGSNVETVSNrtFYGLKELEILQLDHNLLTALNGFEfeGLDSLKELFLQYN 871
Cdd:cd21340 5 THLYLNDKNITKIDNLSLC--KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLE--NLVNLKKLYLGGN 78
|
90 100
....*....|....*....|....*.
gi 116116753 872 RIASIANhtFDHLHGLKILRLDHNRL 897
Cdd:cd21340 79 RISVVEG--LENLTNLEELHIENQRL 102
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
136-354 |
1.66e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 49.31 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 136 SSISLDIAPQVFTselaklqrLDLSQNNMWSVPDGFICPLARLSYI--NLTQ--NRLRD-LSVFHFSASLSTRLSKKCGS 210
Cdd:PRK15370 191 TTIPACIPEQITT--------LILDNNELKSLPENLQGNIKTLYANsnQLTSipATLPDtIQEMELSINRITELPERLPS 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 211 SIVTLDLSHNTIDNLPPAIFSGLGKL------------------TDLRLQSNGLNYIADRAFEGLVSLSRLELSLNRL-T 271
Cdd:PRK15370 263 ALQSLDLFHNKISCLPENLPEELRYLsvydnsirtlpahlpsgiTHLNVQSNSLTALPETLPPGLKTLEAGENALTSLpA 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 272 NLPPELfseakhiKEIYLQNNSLNVLAPGIFSDLKQllvLDLSNNELTSEWIN-PATFGVVQAhptrsfkQQNNEARahd 350
Cdd:PRK15370 343 SLPPEL-------QVLDVSKNQITVLPETLPPTITT---LDVSRNALTNLPENlPAALQIMQA-------SRNNLVR--- 402
|
....
gi 116116753 351 LPRS 354
Cdd:PRK15370 403 LPES 406
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
829-920 |
4.43e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.62 E-value: 4.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 829 SNRTFYGLKELEILQLDHNLLTALnGFEFEGLDSLKELFLQYNRIASIANhTFDHLHGLKILRLDHNRLVEFNVWLLP-K 907
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNlT 182
|
90
....*....|...
gi 116116753 908 QLNDIRLAFNAWS 920
Cdd:COG4886 183 NLKELDLSNNQIT 195
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
792-917 |
5.12e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.93 E-value: 5.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 792 TQIYLDGNNFRSLSShaFLGRKRLKILFLNGSNVETVSNrtFYGLKELEILQLDHNLLTALNGFEFEG------LDSLKE 865
Cdd:cd21340 49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRV 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 116116753 866 LFLQYNRIASIANhtFDHLHGLKILRLDHNRLVEFN--VWLLPK--QLNDIRLAFN 917
Cdd:cd21340 125 LNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSwpSLRELDLTGN 178
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
1081-1216 |
2.83e-41 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 148.63 E-value: 2.83e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 1081 FDAFISYSSKDeaFVAEELAPMLENEDPSYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFKSA 1160
Cdd:smart00255 2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116116753 1161 HHQVLRDRRRRLIVILLGEVPQ--KDLDPDIRLYLKTNtYLQWGDKL---FWEKLRFALPD 1216
Cdd:smart00255 80 LENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVFKKN-YLKWPEDEkeqFWKKALYAVPS 139
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
267-647 |
1.67e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 98.85 E-value: 1.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 267 LNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPATFGVVQAHPTRSFKQQNNEA 346
Cdd:COG4886 2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 347 RAHDLPRSDQRAGVALRKTSSKASAKTFLGLGALHTVILSNNRLCTVDHFtFSGLNSLALLSLDYNRISRIDRqALRNHS 426
Cdd:COG4886 82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 427 ALQELHLNGNKLLQVPDALYDVPLLRTLDLGENHISNIDNAsfrhmahlyglrltennieiirrgtFEAMKSLHILNLSQ 506
Cdd:COG4886 160 NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP-------------------------LGNLTNLEELDLSG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 507 NRLKTVEqASFDNNTKLQAIRLDGNYLTDIAGLfTKLPNLLWLNISDNHLEVFDYALIPTGLQWLDIHANKITELG-NYF 585
Cdd:COG4886 215 NQLTDLP-EPLANLTNLETLDLSNNQLTDLPEL-GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlKEL 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116116753 586 EIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLISKVQSYTFFKKPNLTRVDLFGN 647
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
139-584 |
4.97e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 97.31 E-value: 4.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 139 SLDIAPQVFTSELAKLQRLDLSQNNMWSVPDGFICPLARLSYINLTQNRLRDLSVFHFSASLSTRLSKKCgssIVTLDLS 218
Cdd:COG4886 4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLL---LLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 219 HNTIDNLPPAIFSGLGKLTDLRLQSNglnyiadRAFEGLVSLSRLELSLNRLTNLPPELfSEAKHIKEIYLQNNSLNVLA 298
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 299 PGIfSDLKQLLVLDLSNNELTsewinpatfgvvqahptrsfkqqnnearahDLPRSdqragvalrktsskasaktFLGLG 378
Cdd:COG4886 153 EPL-GNLTNLKSLDLSNNQLT------------------------------DLPEE-------------------LGNLT 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 379 ALHTVILSNNRLCTVDHfTFSGLNSLALLSLDYNRISRIDrQALRNHSALQELHLNGNKLLQVPDaLYDVPLLRTLDLGE 458
Cdd:COG4886 183 NLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSN 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 459 NHISNIDNASfrHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLKtvEQASFDNNTKLQAIRLDGNYLTDIAG 538
Cdd:COG4886 260 NQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN--LLELLILLLLLTTLLLLLLLLKGLLV 335
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 116116753 539 LFTKLPNLLWLNISDNHLEVFDYALIPTGLQWLDIHANKITELGNY 584
Cdd:COG4886 336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
1084-1190 |
2.61e-20 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 87.76 E-value: 2.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 1084 FISYSSKDEAFVaEELAPMLENEDpsYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFKSAHHq 1163
Cdd:pfam13676 2 FISYAGEDRAWA-EWLADALEAAG--YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA- 77
|
90 100
....*....|....*....|....*..
gi 116116753 1164 vLRDRRRRLIVILLGEvpqKDLDPDIR 1190
Cdd:pfam13676 78 -DPEGRKRLIPVRLEC---DLELPGLA 100
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
400-691 |
2.67e-20 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 95.39 E-value: 2.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 400 GLNSLALLSLDYNRISRIDRQALRNHSALQELHLNGNkllqvpDALYDVPLLRTLDLGENHISNIDnASFRHMAHLYGLR 479
Cdd:COG4886 70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELD 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 480 LTENNIEIIRRgTFEAMKSLHILNLSQNRLKTVEqASFDNNTKLQAIRLDGNYLTDIAGLFTKLPNLLWLNISDNHLEVF 559
Cdd:COG4886 143 LSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 560 DYALIP-TGLQWLDIHANKITELGnyfEIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLISKVQSYTFFKKPN 638
Cdd:COG4886 221 PEPLANlTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLG 297
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 116116753 639 LTRVDLFGNKITTLDPNALRISAVPDDRPLPEFYIGGNPYQCDCNLNWLQKSN 691
Cdd:COG4886 298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
37-326 |
2.08e-18 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 89.61 E-value: 2.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 37 WDGYTEDDLTLLCRLRTINSELENTNFSVLHPENTVRLRLQCNDGLFfqsslspgsfkQLTKLHALSIEYCKIANLSEgS 116
Cdd:COG4886 64 SLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-----------NLTNLESLDLSGNQLTDLPE-E 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 117 FQGLKQLVNLTLRthNTDWSSISLDIapqvftSELAKLQRLDLSQNNMWSVPDgFICPLARLSYINLTQNRLRDLSvfhf 196
Cdd:COG4886 132 LANLTNLKELDLS--NNQLTDLPEPL------GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 197 sASLSTRlskkcgSSIVTLDLSHNTIDNLPPAIfSGLGKLTDLRLQSNGLNYIADraFEGLVSLSRLELSLNRLTNLPPE 276
Cdd:COG4886 199 -EPLGNL------TNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 116116753 277 lfSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPA 326
Cdd:COG4886 269 --ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
126-585 |
1.07e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 87.30 E-value: 1.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 126 LTLRTHNTDWSSISLDIAPQVFTSELAKLQRLDLSQNNMWSVPDGFICPLARLSYINLTQNRLRDLSVFHFSASLSTRLS 205
Cdd:COG4886 12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 206 KKCGSSIVTLDLSHNTIdnlppaiFSGLGKLTDLRLQSNGLNYIADrAFEGLVSLSRLELSLNRLTNLPPELfSEAKHIK 285
Cdd:COG4886 92 LGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPL-GNLTNLK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 286 EIYLQNNSLNVLaPGIFSDLKQLLVLDLSNNELTsewinpatfgvvqahptrsfkqqnnearahDLPrsdqragvalrkt 365
Cdd:COG4886 163 SLDLSNNQLTDL-PEELGNLTNLKELDLSNNQIT------------------------------DLP------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 366 sskasaKTFLGLGALHTVILSNNRLCTVDHfTFSGLNSLALLSLDYNRISRIDrqALRNHSALQELHLNGNKLLQVPDaL 445
Cdd:COG4886 199 ------EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-L 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 446 YDVPLLRTLDLGENHISNIdnaSFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLKTVEQASFDNNTKLQA 525
Cdd:COG4886 269 ANLTNLKTLDLSNNQLTDL---KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 526 IRLDGNYLTDIAGLFTKLPNLLWLNISDNHLEVFDYALIPTGLQWLDIHANKITELGNYF 585
Cdd:COG4886 346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
149-537 |
6.10e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 84.99 E-value: 6.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 149 SELAKLQRLDLSQNNmwsvpdgFICPLARLSYINLTQNRLRDLSvfhfsASLStRLSKkcgssIVTLDLSHNTIDNLPPA 228
Cdd:COG4886 93 GDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLP-----EELA-NLTN-----LKELDLSNNQLTDLPEP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 229 IfSGLGKLTDLRLQSNGLNYIaDRAFEGLVSLSRLELSLNRLTNLPPELfSEAKHIKEIYLQNNSLNVLaPGIFSDLKQL 308
Cdd:COG4886 155 L-GNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDL-PEPLANLTNL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 309 LVLDLSNNELTsewinpatfgvvqahptrsfkqqnnearahDLPrsdqragvalrktsskasakTFLGLGALHTVILSNN 388
Cdd:COG4886 231 ETLDLSNNQLT------------------------------DLP--------------------ELGNLTNLEELDLSNN 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 389 RLCTVDHftFSGLNSLALLSLDYNRISRIDRQAL---RNHSALQELHLNGNKLLQVPDALYDVPLLRTLDLGENHISNID 465
Cdd:COG4886 261 QLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELellLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116116753 466 NASFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLKTVEQASFDNNTKLQAIRLDGNYLTDIA 537
Cdd:COG4886 339 TLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
139-578 |
7.79e-15 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 79.89 E-value: 7.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 139 SLDIAPQVFTSEL-------AKLQRLDLSQNNMWSVPDGFICPLARLSYINLTQNRL-----------RDLSVFHFS-AS 199
Cdd:PLN00113 144 TLDLSNNMLSGEIpndigsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgqiprelgqmKSLKWIYLGyNN 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 200 LSTRLSKKCG--SSIVTLDLSHNtidNLPPAIFSGLGKLTDLR---LQSNGLNYIADRAFEGLVSLSRLELSLNRLTNLP 274
Cdd:PLN00113 224 LSGEIPYEIGglTSLNHLDLVYN---NLTGPIPSSLGNLKNLQylfLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEI 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 275 PELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWinPATFGVVQAHPTRSFKQQNNEARAHD-LPR 353
Cdd:PLN00113 301 PELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI--PKNLGKHNNLTVLDLSTNNLTGEIPEgLCS 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 354 SDQRAGVALRKTSSKASAKTFLGL-GALHTVILSNNRLCTVDHFTFSGLNSLALLSLDYNRIS-RIDRQALrNHSALQEL 431
Cdd:PLN00113 379 SGNLFKLILFSNSLEGEIPKSLGAcRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQML 457
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 432 HLNGNKLL-QVPDaLYDVPLLRTLDLGENHISNIDNASFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLK 510
Cdd:PLN00113 458 SLARNKFFgGLPD-SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116116753 511 TVEQASFDNNTKLQAIRLDGNYLT-DIAGLFTKLPNLLWLNISDNHlevFDYALIPTGlQWLDIHANKI 578
Cdd:PLN00113 537 GQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNH---LHGSLPSTG-AFLAINASAV 601
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
62-657 |
1.44e-14 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 79.12 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 62 NFSVLHPENTVRLrlqcndgLFFQSSLSpGSFKQLTKLHAlSIEYCKianlsegsFQGLkqLVNLTLRTHNTDWS--SIS 139
Cdd:PLN00113 22 NFSMLHAEELELL-------LSFKSSIN-DPLKYLSNWNS-SADVCL--------WQGI--TCNNSSRVVSIDLSgkNIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 140 LDIAPQVFtsELAKLQRLDLSQNNM-WSVPDGFICPLARLSYINLTQNrlrdlsvfHFSASLStrlsKKCGSSIVTLDLS 218
Cdd:PLN00113 83 GKISSAIF--RLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNN--------NFTGSIP----RGSIPNLETLDLS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 219 HNTIDNlppAIFSGLGKLTDLRLQSNGLNYIADRAFEGLVSLSRLE---LSLNRLTNLPPELFSEAKHIKEIYLQNNSLN 295
Cdd:PLN00113 149 NNMLSG---EIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEfltLASNQLVGQIPRELGQMKSLKWIYLGYNNLS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 296 VLAPGIFSDLKQLLVLDLSNNELTSEWinPATFGvvqahptrsfkqqnnearahdlprsdqragvalrktsskasaktfl 375
Cdd:PLN00113 226 GEIPYEIGGLTSLNHLDLVYNNLTGPI--PSSLG---------------------------------------------- 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 376 GLGALHTVILSNNRLCTVDHFTFSGLNSLALLSLDYNRISRIDRQALRNHSALQELHLNGNKLL-QVPDALYDVPLLRTL 454
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVL 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 455 DLGENHISNIDNASFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLKTVEQASFDNNTKLQAIRLDGNYLT 534
Cdd:PLN00113 338 QLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFS 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 535 -DIAGLFTKLPNLLWLNISDNHLE--VFDYALIPTGLQWLDIHANKItelgnyfeiesqlalstidasSNQLTEITGSai 611
Cdd:PLN00113 418 gELPSEFTKLPLVYFLDISNNNLQgrINSRKWDMPSLQMLSLARNKF---------------------FGGLPDSFGS-- 474
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 116116753 612 pNSVELLYLNDNLISKVQSYTFFKKPNLTRVDLFGNKITTLDPNAL 657
Cdd:PLN00113 475 -KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDEL 519
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
1081-1176 |
2.33e-14 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 72.40 E-value: 2.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 1081 FDAFISYSSKD--EAFVAEELAPMLENedpSYKLCLHYRDFPVGAYIADNILQAVESSRRTIMVLSENFIKSEWCRFEFK 1158
Cdd:pfam01582 1 YDVFLSFRGSDtrEWFVSHLLKELKQK---GIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELV 77
|
90
....*....|....*...
gi 116116753 1159 SAHHQVLRDrrrRLIVIL 1176
Cdd:pfam01582 78 KILECALDL---GQKVIP 92
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
90-351 |
4.36e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 73.04 E-value: 4.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 90 PGSFKQLTKLHALSIEYCKIANLSEgSFQGLKQLVNLTLrtHNTDWSSISLDIapqvftSELAKLQRLDLSQNNMWSVPD 169
Cdd:COG4886 152 PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDL--SNNQITDLPEPL------GNLTNLEELDLSGNQLTDLPE 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 170 GfICPLARLSYINLTQNRLRDLSVFhfsaslsTRLSKkcgssIVTLDLSHNTIDNLPPAifSGLGKLTDLRLQSNGLNYI 249
Cdd:COG4886 223 P-LANLTNLETLDLSNNQLTDLPEL-------GNLTN-----LEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDL 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 250 ADRAFEGLVSLSRLELSLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPATFG 329
Cdd:COG4886 288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367
|
250 260
....*....|....*....|..
gi 116116753 330 VVQAHPTRSFKQQNNEARAHDL 351
Cdd:COG4886 368 TLGLLGLLEATLLTLALLLLTL 389
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
90-462 |
2.82e-12 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 71.80 E-value: 2.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 90 PGSFKQLTKLHALSIEYCKIANLSEGSFQGLKQLVNLTLRThntdwSSISLDIAPQVFtsELAKLQRLDLSQNNMWSVPD 169
Cdd:PLN00113 253 PSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSD-----NSLSGEIPELVI--QLQNLEILHLFSNNFTGKIP 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 170 GFICPLARLSYINLTQNRlrdlsvfhFSASLSTRLSKKcgSSIVTLDLSHNTIDNLPPAIFSGLGKLTDLRLQSNGLnyi 249
Cdd:PLN00113 326 VALTSLPRLQVLQLWSNK--------FSGEIPKNLGKH--NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL--- 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 250 adrafEGlvslsrlelslnrltNLPPELfSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELtsewinpatfg 329
Cdd:PLN00113 393 -----EG---------------EIPKSL-GACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL----------- 440
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 330 vvqahptrsfkQQNNEARAHDLPrsdQRAGVALRKTSSKASAKTFLGLGALHTVILSNNRLCTVDHFTFSGLNSLALLSL 409
Cdd:PLN00113 441 -----------QGRINSRKWDMP---SLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 116116753 410 DYNRISRIDRQALRNHSALQELHLNGNKLL-QVPDALYDVPLLRTLDLGENHIS 462
Cdd:PLN00113 507 SENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS 560
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
838-897 |
7.12e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.69 E-value: 7.12e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 838 ELEILQLDHNLLTALNGFEFEGLDSLKELFLQYNRIASIANHTFDHLHGLKILRLDHNRL 897
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
814-873 |
6.95e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.99 E-value: 6.95e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 814 RLKILFLNGSNVETVSNRTFYGLKELEILQLDHNLLTALNGFEFEGLDSLKELFLQYNRI 873
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
178-650 |
9.43e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 63.33 E-value: 9.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 178 LSYINLTQNRLRDLSVFHFSASLSTRLSKKCGSS--IVTLDLSHNTID-NLPPAIFsGLGKLTDLRLQSNGLNY-IADRA 253
Cdd:PLN00113 35 LSFKSSINDPLKYLSNWNSSADVCLWQGITCNNSsrVVSIDLSGKNISgKISSAIF-RLPYIQTINLSNNQLSGpIPDDI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 254 FEGLVSLSRLELSLNRLTNLPPELFseAKHIKEIYLQNNSLNVLAP---GIFSDLKqllVLDLSNNELTSEWinPATFGV 330
Cdd:PLN00113 114 FTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPndiGSFSSLK---VLDLGGNVLVGKI--PNSLTN 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 331 VQAHPTRSFKqqnnearahdlprSDQRAGVALRKTSSKASAKTflglgalhtVILSNNRLCTVDHFTFSGLNSLALLSLD 410
Cdd:PLN00113 187 LTSLEFLTLA-------------SNQLVGQIPRELGQMKSLKW---------IYLGYNNLSGEIPYEIGGLTSLNHLDLV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 411 YNRISRIDRQALRNHSALQELHLNGNKLL-QVPDALYDVPLLRTLDLGENHISNIDNASFRHMAHLYGLRLTENNIEIIR 489
Cdd:PLN00113 245 YNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKI 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 490 RGTFEAMKSLHILNLSQNRLK-------------TVEQASFDNNT----------------------------------- 521
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKFSgeipknlgkhnnlTVLDLSTNNLTgeipeglcssgnlfklilfsnslegeipkslgacr 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 522 KLQAIRLDGNYLT-DIAGLFTKLPNLLWLNISDNHLE--VFDYALIPTGLQWLDIHANKIT-ELGNYFEIESqlaLSTID 597
Cdd:PLN00113 405 SLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKR---LENLD 481
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 116116753 598 ASSNQLTEITGSAIPNSVEL--LYLNDNLISKVQSYTFFKKPNLTRVDLFGNKIT 650
Cdd:PLN00113 482 LSRNQFSGAVPRKLGSLSELmqLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
259-318 |
1.96e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.84 E-value: 1.96e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 259 SLSRLELSLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNEL 318
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
380-438 |
2.48e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.45 E-value: 2.48e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 116116753 380 LHTVILSNNRLCTVDHFTFSGLNSLALLSLDYNRISRIDRQALRNHSALQELHLNGNKL 438
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
792-917 |
3.11e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.72 E-value: 3.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 792 TQIYLDGNNFRSLSShAFLGRKRLKILFLNGSNVETVSNrTFYGLKELEILQLDHNLLTALnGFEFEGLDSLKELFLQYN 871
Cdd:COG4886 139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 116116753 872 RIASIANhTFDHLHGLKILRLDHNRLVEFNVWLLPKQLNDIRLAFN 917
Cdd:COG4886 216 QLTDLPE-PLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
449-509 |
4.73e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 53.68 E-value: 4.73e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116116753 449 PLLRTLDLGENHISNIDNASFRHMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRL 509
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
431-651 |
9.61e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 57.10 E-value: 9.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 431 LHLNGNKLLQVPDaLYDVPLLRTLDLGENHISNIDN-ASFRHMAHLYglrLTENNIEIIRRgtFEAMKSLHILNLSQNRL 509
Cdd:cd21340 7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIENlEFLTNLTHLY---LQNNQIEKIEN--LENLVNLKKLYLGGNRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 510 KTVEqasfdnntklqairldgnyltdiaGLfTKLPNLLWLNISDNHLevfdyaliPTGLQWLdihankitelgnyFEIES 589
Cdd:cd21340 81 SVVE------------------------GL-ENLTNLEELHIENQRL--------PPGEKLT-------------FDPRS 114
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116116753 590 QLALS----TIDASSNQLTEITGSAIPNSVELLYLNDNLISKVQ--SYTFFKKPNLTRVDLFGNKITT 651
Cdd:cd21340 115 LAALSnslrVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCK 182
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
474-533 |
1.00e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.91 E-value: 1.00e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 474 HLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLKTVEQASFDNNTKLQAIRLDGNYL 533
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
794-849 |
1.10e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.53 E-value: 1.10e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 116116753 794 IYLDGNNFRSLSSHAFLGRKRLKILFLNGSNVETVSNRTFYGLKELEILQLDHNLL 849
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
210-270 |
4.03e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.99 E-value: 4.03e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116116753 210 SSIVTLDLSHNTIDNLPPAIFSGLGKLTDLRLQSNGLNYIADRAFEGLVSLSRLELSLNRL 270
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
118-321 |
4.35e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 56.59 E-value: 4.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 118 QGLKQLVNLTLRTHNTdwSSISLDiAPQVFTSELAK--LQRLDLSQNNMWSVPDGFIC-----PLARLSYINLTQNRLRD 190
Cdd:cd00116 75 QGLTKGCGLQELDLSD--NALGPD-GCGVLESLLRSssLQELKLNNNGLGDRGLRLLAkglkdLPPALEKLVLGRNRLEG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 191 LSvfhfSASLSTRLSKKCgsSIVTLDLSHNTI-DNLPPAIFSGL---GKLTDLRLQSNGLNYIADRAFEGLV----SLSR 262
Cdd:cd00116 152 AS----CEALAKALRANR--DLKELNLANNGIgDAGIRALAEGLkanCNLEVLDLNNNGLTDEGASALAETLaslkSLEV 225
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116116753 263 LELSLNRLTN-----LPPELFSEAKHIKEIYLQNNSLNVLAPGIFS----DLKQLLVLDLSNNELTSE 321
Cdd:cd00116 226 LNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGEE 293
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
498-556 |
1.35e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.45 E-value: 1.35e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 498 SLHILNLSQNRLKTVEQASFDNNTKLQAIRLDGNYLTDI-AGLFTKLPNLLWLNISDNHL 556
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
235-294 |
8.67e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.13 E-value: 8.67e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 235 KLTDLRLQSNGLNYIADRAFEGLVSLSRLELSLNRLTNLPPELFSEAKHIKEIYLQNNSL 294
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
792-897 |
8.80e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 51.33 E-value: 8.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 792 TQIYLDGNNFRSLSSHAFLgrKRLKILFLNGSNVETVSNrtFYGLKELEILQLDHNLLTALNGFEfeGLDSLKELFLQYN 871
Cdd:cd21340 5 THLYLNDKNITKIDNLSLC--KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLE--NLVNLKKLYLGGN 78
|
90 100
....*....|....*....|....*.
gi 116116753 872 RIASIANhtFDHLHGLKILRLDHNRL 897
Cdd:cd21340 79 RISVVEG--LENLTNLEELHIENQRL 102
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
421-651 |
1.26e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 421 ALRNHSALQELHLNGNKLLQVPDALYDVP-------LLRTLDLGenhisniDNASFRHMAHLYglrltenniEIIRRGTf 493
Cdd:cd00116 46 ALRPQPSLKELCLSLNETGRIPRGLQSLLqgltkgcGLQELDLS-------DNALGPDGCGVL---------ESLLRSS- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 494 eamkSLHILNLSQNRL-----KTVEQASFDNNTKLQAIRLDGNYLT-----DIAGLFTKLPNLLWLNISDNHLEVFDYAL 563
Cdd:cd00116 109 ----SLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEgasceALAKALRANRDLKELNLANNGIGDAGIRA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 564 I------PTGLQWLDIHANKITELGNYF---EIESQLALSTIDASSNQLTEITGSAIPN-------SVELLYLNDNLISK 627
Cdd:cd00116 185 LaeglkaNCNLEVLDLNNNGLTDEGASAlaeTLASLKSLEVLNLGDNNLTDAGAAALASallspniSLLTLSLSCNDITD 264
|
250 260
....*....|....*....|....*...
gi 116116753 628 VQSYTF----FKKPNLTRVDLFGNKITT 651
Cdd:cd00116 265 DGAKDLaevlAEKESLLELDLRGNKFGE 292
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
376-594 |
1.48e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 376 GLGALHTVILSNNRLCTVDHFT--FSGLNSLALlsldynrisridrQALRNHSALQELHLNGNKLLQ-----VPDALYDV 448
Cdd:cd00116 69 GLQSLLQGLTKGCGLQELDLSDnaLGPDGCGVL-------------ESLLRSSSLQELKLNNNGLGDrglrlLAKGLKDL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 449 PL-LRTLDLGENHISNIDNAS----FRHMAHLYGLRLTENNI--EIIRRgTFEAMKS---LHILNLSQNRLkTVEQAS-- 516
Cdd:cd00116 136 PPaLEKLVLGRNRLEGASCEAlakaLRANRDLKELNLANNGIgdAGIRA-LAEGLKAncnLEVLDLNNNGL-TDEGASal 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 517 ---FDNNTKLQAIRLDGNYLTD--IA----GLFTKLPNLLWLNISDNHLE----------VFDYALiptgLQWLDIHANK 577
Cdd:cd00116 214 aetLASLKSLEVLNLGDNNLTDagAAalasALLSPNISLLTLSLSCNDITddgakdlaevLAEKES----LLELDLRGNK 289
|
250
....*....|....*..
gi 116116753 578 ITELGNYFEIESQLALS 594
Cdd:cd00116 290 FGEEGAQLLAESLLEPG 306
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
236-511 |
1.86e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 236 LTDLRLQSNGLNYIADRAFEGLV----SLSRLELSLNRL------TNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDL 305
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALrpqpSLKELCLSLNETgriprgLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 306 KQ---LLVLDLSNNELTSEwinpatfgvVQAHPTRSFKQQNNEARAHDLPRSdqragvALRKTSSKASAKTFLGLGALHT 382
Cdd:cd00116 105 LRsssLQELKLNNNGLGDR---------GLRLLAKGLKDLPPALEKLVLGRN------RLEGASCEALAKALRANRDLKE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 383 VILSNNrlctvdHFTFSGLNSLAllsldynrisridrQALRNHSALQELHLNGNKL-----LQVPDALYDVPLLRTLDLG 457
Cdd:cd00116 170 LNLANN------GIGDAGIRALA--------------EGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLG 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116116753 458 ENHISN-----IDNASFRHMAHLYGLRLTENNIEIIRRGTF----EAMKSLHILNLSQNRLKT 511
Cdd:cd00116 230 DNNLTDagaaaLASALLSPNISLLTLSLSCNDITDDGAKDLaevlAEKESLLELDLRGNKFGE 292
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
283-328 |
2.09e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 46.36 E-value: 2.09e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 116116753 283 HIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSewINPATF 328
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAF 45
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
403-461 |
2.33e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.98 E-value: 2.33e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 403 SLALLSLDYNRISRIDRQALRNHSALQELHLNGNKLLQV-PDALYDVPLLRTLDLGENHI 461
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
428-485 |
6.22e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.82 E-value: 6.22e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 116116753 428 LQELHLNGNKLLQV-PDALYDVPLLRTLDLGENHISNIDNASFRHMAHLYGLRLTENNI 485
Cdd:pfam13855 3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
136-354 |
1.66e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 49.31 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 136 SSISLDIAPQVFTselaklqrLDLSQNNMWSVPDGFICPLARLSYI--NLTQ--NRLRD-LSVFHFSASLSTRLSKKCGS 210
Cdd:PRK15370 191 TTIPACIPEQITT--------LILDNNELKSLPENLQGNIKTLYANsnQLTSipATLPDtIQEMELSINRITELPERLPS 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 211 SIVTLDLSHNTIDNLPPAIFSGLGKL------------------TDLRLQSNGLNYIADRAFEGLVSLSRLELSLNRL-T 271
Cdd:PRK15370 263 ALQSLDLFHNKISCLPENLPEELRYLsvydnsirtlpahlpsgiTHLNVQSNSLTALPETLPPGLKTLEAGENALTSLpA 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 272 NLPPELfseakhiKEIYLQNNSLNVLAPGIFSDLKQllvLDLSNNELTSEWIN-PATFGVVQAhptrsfkQQNNEARahd 350
Cdd:PRK15370 343 SLPPEL-------QVLDVSKNQITVLPETLPPTITT---LDVSRNALTNLPENlPAALQIMQA-------SRNNLVR--- 402
|
....
gi 116116753 351 LPRS 354
Cdd:PRK15370 403 LPES 406
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
90-318 |
1.90e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.78 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 90 PGSFKQLTKLHALSIEYCKIANLSEgSFQGLKQLVNLTLRtHN--TDWSSISldiapqvftsELAKLQRLDLSQNNMWSV 167
Cdd:COG4886 198 PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLS-NNqlTDLPELG----------NLTNLEELDLSNNQLTDL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 168 PDgfICPLARLSYINLTQNRLRDLSVFHFSASLSTRLSKKCGSSIVTLDLSHNTIDNLPPAIFSGLGKLTDLRLQSNGLN 247
Cdd:COG4886 266 PP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116116753 248 YIADRAFEGLVSLSRLELSLNRLTNLPPELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNEL 318
Cdd:COG4886 344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
377-556 |
3.48e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 46.70 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 377 LGALHTVILSNNRLCTVDHFtfSGLNSLALLSLDYNRISRIDrqALRNHSALQELHLNGNKL--LQVPDALydvPLLRTL 454
Cdd:cd21340 1 LKRITHLYLNDKNITKIDNL--SLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIekIENLENL---VNLKKL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 455 DLGENHISNIDNasfrhmahLYGLR-LTENNIE--IIRRG---TFEAM------KSLHILNLSQNRLKTVEQ-ASFDNnt 521
Cdd:cd21340 74 YLGGNRISVVEG--------LENLTnLEELHIEnqRLPPGeklTFDPRslaalsNSLRVLNISGNNIDSLEPlAPLRN-- 143
|
170 180 190
....*....|....*....|....*....|....*...
gi 116116753 522 kLQAIRLDGNYLTD---IAGLFTKLPNLLWLNISDNHL 556
Cdd:cd21340 144 -LEQLDASNNQISDleeLLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
829-920 |
4.43e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.62 E-value: 4.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 829 SNRTFYGLKELEILQLDHNLLTALnGFEFEGLDSLKELFLQYNRIASIANhTFDHLHGLKILRLDHNRLVEFNVWLLP-K 907
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNlT 182
|
90
....*....|...
gi 116116753 908 QLNDIRLAFNAWS 920
Cdd:COG4886 183 NLKELDLSNNQIT 195
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
792-917 |
5.12e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.93 E-value: 5.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 792 TQIYLDGNNFRSLSShaFLGRKRLKILFLNGSNVETVSNrtFYGLKELEILQLDHNLLTALNGFEFEG------LDSLKE 865
Cdd:cd21340 49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRV 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 116116753 866 LFLQYNRIASIANhtFDHLHGLKILRLDHNRLVEFN--VWLLPK--QLNDIRLAFN 917
Cdd:cd21340 125 LNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSwpSLRELDLTGN 178
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
241-657 |
7.35e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 46.71 E-value: 7.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 241 LQSNGLNYIADRAFEGLVSLSRLELSLNRLTNLPPELFSEAKHIKeIYLqnNSLNVLAPGIFSDLKQLLVLDLSNNELTS 320
Cdd:COG5238 16 LSANPATTEQSELTKRATIVNLRSYHLHGGAILLARYLQSRSSIT-QYL--RFEGQGDPGLNPVALEKAAEAFPTQLLVV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 321 EWINPA----TFGVVQAHPTRSFKQQNNEARAHDLPRSDQRAGVALRKTSSKASAKTFLGLGALHTVILSNNRLCTVDHF 396
Cdd:COG5238 93 DWEGAEevspVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAIS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 397 TFSGL--NSLALLSLDYNRISridrqalrnhsalqelhLNGNKLLQvpDALYDVPLLRTLDLGENHISniDNASFRHMAH 474
Cdd:COG5238 173 MAKALqnNSVETVYLGCNQIG-----------------DEGIEELA--EALTQNTTVTTLWLKRNPIG--DEGAEILAEA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 475 LYGLrltennieiirrgtfeamKSLHILNLSQNRLKTVEQASF----DNNTKLQAIRLDGNYLTD-----IAGLFTKLPN 545
Cdd:COG5238 232 LKGN------------------KSLTTLDLSNNQIGDEGVIALaealKNNTTVETLYLSGNQIGAegaiaLAKALQGNTT 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 546 LLWLNISDNHLEVFDYALIPTGLQW------LDIHANKITELGNYF---EIESQLALSTIDASSNQLTEITGSAIPNsve 616
Cdd:COG5238 294 LTSLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGIGAQGAIAlakALQENTTLHSLDLSDNQIGDEGAIALAK--- 370
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 116116753 617 llYLNDNliskvqsytffkkPNLTRVDLFGNKITTLDPNAL 657
Cdd:COG5238 371 --YLEGN-------------TTLRELNLGKNNIGKQGAEAL 396
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
251-580 |
9.94e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 46.32 E-value: 9.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 251 DRAFEGLVSLSR-LELSLNRLTNLPpELFSEAKHIKEIYLQNNSLNVLAPGIFSDLKQLL-----VLDLSNNELTSEWIn 324
Cdd:COG5238 120 RRIMAKTLEDSLiLYLALPRRINLI-QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQnnsveTVYLGCNQIGDEGI- 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 325 patfgvvqahptRSFKQ---QNNEARAHDLPRSdqragvALRKTSSKASAKTFLGLGALHTVILSNNrlctvdHFTFSGL 401
Cdd:COG5238 198 ------------EELAEaltQNTTVTTLWLKRN------PIGDEGAEILAEALKGNKSLTTLDLSNN------QIGDEGV 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 402 NSLAllsldynrisridrQALRNHSALQELHLNGNKL-----LQVPDALYDVPLLRTLDLGENHISNidnasfrhmahly 476
Cdd:COG5238 254 IALA--------------EALKNNTTVETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGD------------- 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 477 glrltENNIEIIRrgTFEAMKSLHILNLSQNRLKTVEQ----ASFDNNTKLQAIRLDGNYLTD-----IAGLFTKLPNLL 547
Cdd:COG5238 307 -----EGAIALAE--GLQGNKTLHTLNLAYNGIGAQGAialaKALQENTTLHSLDLSDNQIGDegaiaLAKYLEGNTTLR 379
|
330 340 350
....*....|....*....|....*....|....*....
gi 116116753 548 WLNISDNHL------EVFDyALIPTGLQWLDIHANKITE 580
Cdd:COG5238 380 ELNLGKNNIgkqgaeALID-ALQTNRLHTLILDGNLIGA 417
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
521-578 |
1.15e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.36 E-value: 1.15e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116116753 521 TKLQAIRLDGNYLTDI-AGLFTKLPNLLWLNISDNHLEVFDYALI--PTGLQWLDIHANKI 578
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
792-920 |
1.91e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.69 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 792 TQIYLDGNNFRSLSShAFLGRKRLKILFLNGSNVETVSNrtFYGLKELEILQLDHNLLTALNgfEFEGLDSLKELFLQYN 871
Cdd:COG4886 208 EELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNN 282
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 116116753 872 RIASIANHTFDHLHGLKILRLDHNRLVEFNVWLLPKQLNDIRLAFNAWS 920
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
93-321 |
2.31e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 45.04 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 93 FKQLTKLHALSIEYCkiaNLSEGSFQGL-------KQLVNLTLRTHNTDWSSISLDIAPQVFTSeLAKLQRLDLSQNNMW 165
Cdd:cd00116 19 LPKLLCLQVLRLEGN---TLGEEAAKALasalrpqPSLKELCLSLNETGRIPRGLQSLLQGLTK-GCGLQELDLSDNALG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 166 SVPDGFICPLAR---LSYINLTQNRLRDLSVFHFSASLstrlsKKCGSSIVTLDLSHNTIDNLPPA----IFSGLGKLTD 238
Cdd:cd00116 95 PDGCGVLESLLRsssLQELKLNNNGLGDRGLRLLAKGL-----KDLPPALEKLVLGRNRLEGASCEalakALRANRDLKE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 239 LRLQSNGLNyiaDRAFEGLVslsrlelslnrltnlppELFSEAKHIKEIYLQNNSLN----VLAPGIFSDLKQLLVLDLS 314
Cdd:cd00116 170 LNLANNGIG---DAGIRALA-----------------EGLKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLG 229
|
....*..
gi 116116753 315 NNELTSE 321
Cdd:cd00116 230 DNNLTDA 236
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
175-320 |
1.05e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.08 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 175 LARLSYINLTQNRLRDLSVFHFSASLST------RLSK----KCGSSIVTLDLSHN---TIDNLppaifSGLGKLTDLRL 241
Cdd:cd21340 1 LKRITHLYLNDKNITKIDNLSLCKNLKVlylydnKITKienlEFLTNLTHLYLQNNqieKIENL-----ENLVNLKKLYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 242 qsnGLNYIadRAFEGLVSLSRL-ELSLNRlTNLPPE---------LFSEAKHIKEIYLQNNSLNVLAPgiFSDLKQLLVL 311
Cdd:cd21340 76 ---GGNRI--SVVEGLENLTNLeELHIEN-QRLPPGekltfdprsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQL 147
|
....*....
gi 116116753 312 DLSNNELTS 320
Cdd:cd21340 148 DASNNQISD 156
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
862-901 |
2.01e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 2.01e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 116116753 862 SLKELFLQYNRIASIANHTFDHLHGLKILRLDHNRLVEFN 901
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS 41
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
370-414 |
6.00e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 36.35 E-value: 6.00e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 116116753 370 SAKTFLGLGALHTVILSNNRLCTVDHFTFSGLNSLALLSLDYNRI 414
Cdd:pfam13855 17 DDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
614-658 |
6.49e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 36.35 E-value: 6.49e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 116116753 614 SVELLYLNDNLISKVQSYTFFKKPNLTRVDLFGNKITTLDPNALR 658
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS 46
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
463-534 |
7.33e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 40.57 E-value: 7.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116116753 463 NIDNASFR--------HMAHLYGLRLTENNIEIIRRGTFEAMKSLHILNLSQNRLKTVEQASFDNNTKLQAIRLDGNYLT 534
Cdd:PLN03150 424 GLDNQGLRgfipndisKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
|
|
| |
