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Conserved domains on  [gi|1159331295|ref|WP_079261610|]
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c-type cytochrome [Campylobacter jejuni]

Protein Classification

c-type cytochrome( domain architecture ID 11461647)

c-type cytochrome is an electron carrier protein that contains one or more heme groups; such as thiosulfate dehydrogenase and cytochrome bc1 complex cytochrome c subunit, both of which bind 2 heme c groups per subunit

CATH:  1.10.760.10
Gene Ontology:  GO:0020037|GO:0009055|GO:0046872
PubMed:  31252007|22723177|18568041|12594933|10647174|10395550
SCOP:  3000815

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TsdA COG3258
Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion ...
 8-139 2.42e-56

Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion transport and metabolism];


:

Pssm-ID: 442489 [Multi-domain]  Cd Length: 216  Bit Score: 175.81  E-value: 2.42e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159331295   8 VGIWARFPQYNARGDKVITLADRINGCFERSTNGKRMPSDTPEMKAMLTYMQWLSQGVPVGAKIEGQGLKKIDFILKAAD 87
Cdd:COG3258    37 WGVAAAYPAYRARNGKVVTLEDRINGCFTRSMNGKPLPLDSAEMKALVAYLRWLSRGLPVGVKLDGRGLPKLPKPAASAD 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1159331295  88 PKKGKAIYMDKCAVCHQENGLGLKNEDSTgayYLYPPLWGDDSYNTGAGMYR 139
Cdd:COG3258   117 VERGKALYAERCASCHGADGEGQGRADGQ---YGFPPLWGGDSYNDGAGMAR 165
 
Name Accession Description Interval E-value
TsdA COG3258
Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion ...
 8-139 2.42e-56

Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion transport and metabolism];


Pssm-ID: 442489 [Multi-domain]  Cd Length: 216  Bit Score: 175.81  E-value: 2.42e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159331295   8 VGIWARFPQYNARGDKVITLADRINGCFERSTNGKRMPSDTPEMKAMLTYMQWLSQGVPVGAKIEGQGLKKIDFILKAAD 87
Cdd:COG3258    37 WGVAAAYPAYRARNGKVVTLEDRINGCFTRSMNGKPLPLDSAEMKALVAYLRWLSRGLPVGVKLDGRGLPKLPKPAASAD 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1159331295  88 PKKGKAIYMDKCAVCHQENGLGLKNEDSTgayYLYPPLWGDDSYNTGAGMYR 139
Cdd:COG3258   117 VERGKALYAERCASCHGADGEGQGRADGQ---YGFPPLWGGDSYNDGAGMAR 165
thiosulf_SoxA TIGR04484
sulfur oxidation c-type cytochrome SoxA; Members of this family are SoxA, a c-type cytochrome ...
 9-106 3.22e-16

sulfur oxidation c-type cytochrome SoxA; Members of this family are SoxA, a c-type cytochrome with a CxxCH motif, part of a heterodimer with SoxX. SoxXA, SoxYZ, and SoxB contribute to thiosulfate oxidation to sulfate.


Pssm-ID: 275277 [Multi-domain]  Cd Length: 211  Bit Score: 72.24  E-value: 3.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159331295   9 GIWARFPQYNARGDKVITLADRINGCFERSTNGKRMPSDTPEMKAMLTYMQWLSQGVPVGAKIEGQGLKkidfilkaADP 88
Cdd:TIGR04484  37 GAAAQYPRYDEDTGKVVTLEQRINACREANQGEKPLKVKSGEMEALTAYIASQSRGMPINVKIDHPRAK--------AAY 108

                          90       100
                  ....*....|....*....|....*
gi 1159331295  89 KKGKAIYMDK-------CAVCHQEN 106
Cdd:TIGR04484 109 ELGKELFYTRrgqldlsCASCHVQN 133
Cytochrom_C pfam00034
Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and ...
 89-127 5.33e-06

Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.


Pssm-ID: 459641 [Multi-domain]  Cd Length: 89  Bit Score: 42.53  E-value: 5.33e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1159331295  89 KKGKAIYMDKCAVCHQENGlglknedsTGAYYLYPPLWG 127
Cdd:pfam00034   1 ARGKKLFAANCAACHGVNG--------EGAGAGGPDLAG 31
PRK14486 PRK14486
putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional
 50-109 6.72e-04

putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional


Pssm-ID: 184704 [Multi-domain]  Cd Length: 294  Bit Score: 38.65  E-value: 6.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1159331295  50 EMKAMLTYMQWLSQGVPVGAKIEGQ--GLKKIDFILKAADPKKGKAIYMDKCAVCHQENGLG 109
Cdd:PRK14486  175 EMDAMVAYMQSLGKAIPRRAAGGAEvdLELPNPFATDVAAIAKGKALYDANCAACHGDEAQG 236
 
Name Accession Description Interval E-value
TsdA COG3258
Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion ...
 8-139 2.42e-56

Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion transport and metabolism];


Pssm-ID: 442489 [Multi-domain]  Cd Length: 216  Bit Score: 175.81  E-value: 2.42e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159331295   8 VGIWARFPQYNARGDKVITLADRINGCFERSTNGKRMPSDTPEMKAMLTYMQWLSQGVPVGAKIEGQGLKKIDFILKAAD 87
Cdd:COG3258    37 WGVAAAYPAYRARNGKVVTLEDRINGCFTRSMNGKPLPLDSAEMKALVAYLRWLSRGLPVGVKLDGRGLPKLPKPAASAD 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1159331295  88 PKKGKAIYMDKCAVCHQENGLGLKNEDSTgayYLYPPLWGDDSYNTGAGMYR 139
Cdd:COG3258   117 VERGKALYAERCASCHGADGEGQGRADGQ---YGFPPLWGGDSYNDGAGMAR 165
thiosulf_SoxA TIGR04484
sulfur oxidation c-type cytochrome SoxA; Members of this family are SoxA, a c-type cytochrome ...
 9-106 3.22e-16

sulfur oxidation c-type cytochrome SoxA; Members of this family are SoxA, a c-type cytochrome with a CxxCH motif, part of a heterodimer with SoxX. SoxXA, SoxYZ, and SoxB contribute to thiosulfate oxidation to sulfate.


Pssm-ID: 275277 [Multi-domain]  Cd Length: 211  Bit Score: 72.24  E-value: 3.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159331295   9 GIWARFPQYNARGDKVITLADRINGCFERSTNGKRMPSDTPEMKAMLTYMQWLSQGVPVGAKIEGQGLKkidfilkaADP 88
Cdd:TIGR04484  37 GAAAQYPRYDEDTGKVVTLEQRINACREANQGEKPLKVKSGEMEALTAYIASQSRGMPINVKIDHPRAK--------AAY 108

                          90       100
                  ....*....|....*....|....*
gi 1159331295  89 KKGKAIYMDK-------CAVCHQEN 106
Cdd:TIGR04484 109 ELGKELFYTRrgqldlsCASCHVQN 133
Cytochrom_C pfam00034
Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and ...
 89-127 5.33e-06

Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.


Pssm-ID: 459641 [Multi-domain]  Cd Length: 89  Bit Score: 42.53  E-value: 5.33e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1159331295  89 KKGKAIYMDKCAVCHQENGlglknedsTGAYYLYPPLWG 127
Cdd:pfam00034   1 ARGKKLFAANCAACHGVNG--------EGAGAGGPDLAG 31
Cyc7 COG3474
Cytochrome c2 [Energy production and conversion];
86-127 3.78e-04

Cytochrome c2 [Energy production and conversion];


Pssm-ID: 442697 [Multi-domain]  Cd Length: 101  Bit Score: 37.55  E-value: 3.78e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1159331295  86 ADPKKGKAIYMDKCAVCHQENGLGlknEDSTGayylyPPLWG 127
Cdd:COG3474     1 GDAAAGEKLFNRKCAACHSVDGGA---GNRVG-----PNLNG 34
CccA COG2010
Cytochrome c, mono- and diheme variants [Energy production and conversion];
84-136 5.38e-04

Cytochrome c, mono- and diheme variants [Energy production and conversion];


Pssm-ID: 441613 [Multi-domain]  Cd Length: 169  Bit Score: 38.39  E-value: 5.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1159331295  84 KAADPKKGKAIYMDKCAVCHQENGLGlknedSTGAyylYPPLWGDDSYNTGAG 136
Cdd:COG2010    85 DAEALARGKALYEQNCAACHGADGKG-----GLGA---APNLTDDALYGGDPE 129
PRK14486 PRK14486
putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional
 50-109 6.72e-04

putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional


Pssm-ID: 184704 [Multi-domain]  Cd Length: 294  Bit Score: 38.65  E-value: 6.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1159331295  50 EMKAMLTYMQWLSQGVPVGAKIEGQ--GLKKIDFILKAADPKKGKAIYMDKCAVCHQENGLG 109
Cdd:PRK14486  175 EMDAMVAYMQSLGKAIPRRAAGGAEvdLELPNPFATDVAAIAKGKALYDANCAACHGDEAQG 236
CxxCH_TIGR02603 TIGR02603
putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain ...
 86-109 1.26e-03

putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain limited to very few species but expanded into large paralogous families in some species that conain it. We find it in over 20 copies each in Pirellula sp. strain 1 (phylum Planctomycetes) and Verrucomicrobium spinosum DSM 4136 (phylum Verrucomicrobia), and no matches above trusted cutoff an any other species so far. This domain, about 140 amino acids long, contains an absolutely conserved motif CxxCH, the cytochrome c family heme-binding site signature (PS00190).


Pssm-ID: 274224  Cd Length: 133  Bit Score: 36.95  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|....
gi 1159331295  86 ADPKKGKAIYMDKCAVCHQENGLG 109
Cdd:TIGR02603   1 GDAARGKAVFAKVCYLCHRIGGQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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