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Conserved domains on  [gi|1159261216|ref|NP_001336318|]
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PEX5-related protein isoform 11 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11929115)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
378-647 5.56e-25

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 104.32  E-value: 5.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 378 DPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKykylvkskk 457
Cdd:COG0457     4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPD--------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 458 gspgltrrmskspvdssvlegvkelyleaahqngdmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLG 537
Cdd:COG0457    75 -------------------------------------DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLG 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 538 ATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALR 617
Cdd:COG0457   118 LALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLL 197

                         250       260       270
                  ....*....|....*....|....*....|
gi 1159261216 618 IALSLMDQPELFQAANLGDLDVLLRAFNLD 647
Cdd:COG0457   198 ALLLALEQALRKKLAILTLAALAELLLLAL 227
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 276-449 2.12e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.39  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 276 ALLSRNHSLEEEFERAKAAVESDTEfWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDW------- 348
Cdd:COG3914    33 EAAALAAALGLALLLLAALAEAAAA-ALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRAlalnpdn 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 349 -PGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYT 427
Cdd:COG3914   112 aEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191

                         170       180
                  ....*....|....*....|..
gi 1159261216 428 NTGHQQDACDALKNWIKQNPKY 449
Cdd:COG3914   192 DLGRLEEAIAAYRRALELDPDN 213
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
378-647 5.56e-25

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 104.32  E-value: 5.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 378 DPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKykylvkskk 457
Cdd:COG0457     4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPD--------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 458 gspgltrrmskspvdssvlegvkelyleaahqngdmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLG 537
Cdd:COG0457    75 -------------------------------------DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLG 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 538 ATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALR 617
Cdd:COG0457   118 LALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLL 197

                         250       260       270
                  ....*....|....*....|....*....|
gi 1159261216 618 IALSLMDQPELFQAANLGDLDVLLRAFNLD 647
Cdd:COG0457   198 ALLLALEQALRKKLAILTLAALAELLLLAL 227
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 353-583 3.14e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 66.65  E-value: 3.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 353 EEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQ 432
Cdd:TIGR02917  27 EAAKSYLQKNKYKAAIIQLKNALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKF 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 433 QDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMskspvdssvLEGVKELYLEAAHQNGDmiDPDLQTGLGVLFHLSGEF 512
Cdd:TIGR02917 107 QQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQ---------LELAQKSYEQALAIDPR--SLYAKLGLAQLALAENRF 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1159261216 513 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREA 583
Cdd:TIGR02917 176 DEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 276-449 2.12e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.39  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 276 ALLSRNHSLEEEFERAKAAVESDTEfWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDW------- 348
Cdd:COG3914    33 EAAALAAALGLALLLLAALAEAAAA-ALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRAlalnpdn 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 349 -PGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYT 427
Cdd:COG3914   112 aEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191

                         170       180
                  ....*....|....*....|..
gi 1159261216 428 NTGHQQDACDALKNWIKQNPKY 449
Cdd:COG3914   192 DLGRLEEAIAAYRRALELDPDN 213
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 370-584 2.65e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 46.47  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 370 FMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNL-KALMAL--------AVSYTNTGHQqdacdALK 440
Cdd:cd24142    22 FLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGyEKYLYLgqlsggeeALQYYEKGIE-----ILE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 441 NWIKQNPKYKYLvkSKKGSPGLTRRMskspvdSSVLEGVKELYL-------------EAAHQNGDMIDPD----LQTgLG 503
Cdd:cd24142    97 EELQALQAASAE--AEEEAEELKRKL------SSALCALAEIYMtdlcdepdaeqrcEELITKALELDPTnpeaLQT-LA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 504 VLfHLS-GEFNRAIDAFNAAltvrpedYSLWNRLGATLANGDRSEEAVEAYTRALEiqpgfirSRYNLGISCINLGAYRE 582
Cdd:cd24142   168 SL-RISqQRPDEAKEALRRS-------LELWKDLKEEDEEEAEEDEAEEEDVPSYE-------FRISLAKLLIELEMYEE 232


                  ..
gi 1159261216 583 AV 584
Cdd:cd24142   233 AL 234
TPR_12 pfam13424
Tetratricopeptide repeat;
531-596 3.22e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 3.22e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1159261216 531 SLWNRLGATLANGDRSEEAVEAYTRALEIQ--------PGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRK 596
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
PRK11189 PRK11189
lipoprotein NlpI; Provisional
 502-551 1.51e-03

lipoprotein NlpI; Provisional


Pssm-ID: 236875 [Multi-domain]  Cd Length: 296  Bit Score: 41.03  E-value: 1.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1159261216 502 LGVLFHLSGEFNRAIDAFNAALTVRPE-DYSLWNRlGATLANGDRSEEAVE 551
Cdd:PRK11189  104 LGIYLTQAGNFDAAYEAFDSVLELDPTyNYAYLNR-GIALYYGGRYELAQD 153
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 382-415 8.98e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.34  E-value: 8.98e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1159261216  382 AEAWQFLGITQAENENEQAAIVALQRCLELQPNN 415
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
378-647 5.56e-25

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 104.32  E-value: 5.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 378 DPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKykylvkskk 457
Cdd:COG0457     4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPD--------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 458 gspgltrrmskspvdssvlegvkelyleaahqngdmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLG 537
Cdd:COG0457    75 -------------------------------------DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLG 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 538 ATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALR 617
Cdd:COG0457   118 LALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLL 197

                         250       260       270
                  ....*....|....*....|....*....|
gi 1159261216 618 IALSLMDQPELFQAANLGDLDVLLRAFNLD 647
Cdd:COG0457   198 ALLLALEQALRKKLAILTLAALAELLLLAL 227
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 385-594 6.07e-18

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 84.40  E-value: 6.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 385 WQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKykylvkskkgSPGLTR 464
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD----------RAEALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 465 RMSKSPVDSSVLEGVKELYLEAAHQNGDmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGD 544
Cdd:COG2956    81 ELAQDYLKAGLLDRAEELLEKLLELDPD--DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQG 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1159261216 545 RSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQ 594
Cdd:COG2956   159 DYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
494-594 8.79e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 80.44  E-value: 8.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 494 IDPDL---QTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNL 570
Cdd:COG0457     3 LDPDDaeaYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                          90       100
                  ....*....|....*....|....
gi 1159261216 571 GISCINLGAYREAVSNFLTALSLQ 594
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELD 106
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
502-646 9.58e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 79.57  E-value: 9.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 502 LGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYR 581
Cdd:COG4785    79 RGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYE 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1159261216 582 EAVSNFLTALSLQRKSRNQqqvphpaisgNIWAALRI-------ALSLMDQPELFQAANLGDLDVLLRAFNL 646
Cdd:COG4785   159 LAIADLEKALELDPNDPER----------ALWLYLAErkldpekALALLLEDWATAYLLQGDTEEARELFKL 220
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 372-594 3.27e-16

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 82.35  E-value: 3.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 372 EAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYky 451
Cdd:COG3914    34 AAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDN-- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 452 lvkskkgspgltrrmskspvdssvlegvkelylEAAHQNgdmidpdlqtgLGVLFHLSGEFNRAIDAFNAALTVRPEDYS 531
Cdd:COG3914   112 ---------------------------------AEALFN-----------LGNLLLALGRLEEALAALRRALALNPDFAE 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1159261216 532 LWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQ 594
Cdd:COG3914   148 AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELD 210
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 351-570 4.89e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 78.50  E-value: 4.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 351 AFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTG 430
Cdd:COG3914    47 LLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALG 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 431 HQQDACDALKNWIKQNPKYkylvkskkgspgltrrmskspvdssvlegvkelylEAAHQNgdmidpdlqtgLGVLFHLSG 510
Cdd:COG3914   127 RLEEALAALRRALALNPDF-----------------------------------AEAYLN-----------LGEALRRLG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 511 EFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNL 570
Cdd:COG3914   161 RLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 380-563 3.88e-14

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 69.84  E-value: 3.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 380 GDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKykylvkskkgs 459
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD----------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 460 pgltrrmskspvdssvlegvkelyleaahqngdmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGAT 539
Cdd:COG4783    71 -----------------------------------EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA 115

                         170       180
                  ....*....|....*....|....
gi 1159261216 540 LANGDRSEEAVEAYTRALEIQPGF 563
Cdd:COG4783   116 YRALGRPDEAIAALEKALELDPDD 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 495-603 4.79e-14

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 69.26  E-value: 4.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 495 DPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISC 574
Cdd:COG4235    16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAA 95

                          90       100
                  ....*....|....*....|....*....
gi 1159261216 575 INLGAYREAVSNFLTALSLQRKSRNQQQV 603
Cdd:COG4235    96 FQQGDYAEAIAAWQKLLALLPADAPARLL 124
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 497-648 1.12e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.60  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 497 DLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCIN 576
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1159261216 577 LGAYREAVSNFLTALSLQRKsrnqqqvpHPAisgniwAALRIALSLMDQPELFQAanlgdLDVLLRAFNLDP 648
Cdd:COG4783    85 AGDYDEALALLEKALKLDPE--------HPE------AYLRLARAYRALGRPDEA-----IAALEKALELDP 137
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 368-541 1.84e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 64.64  E-value: 1.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 368 ILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNP 447
Cdd:COG4235     3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 448 KykylvkskkgspgltrrmskspvdssvlegvkelyleaahqngdmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRP 527
Cdd:COG4235    83 D----------------------------------------------NPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116

                         170
                  ....*....|....
gi 1159261216 528 EDySLWNRLGATLA 541
Cdd:COG4235   117 AD-APARLLEASIA 129
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
505-598 7.49e-12

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 61.72  E-value: 7.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 505 LFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAvEAYTRALEIQPGFIRSRYNLGISCINLGAYREAV 584
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                          90
                  ....*....|....
gi 1159261216 585 SNFLTALSLQRKSR 598
Cdd:COG3063    80 AYLERALELDPSAL 93
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 350-594 8.09e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.29  E-value: 8.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 350 GAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNT 429
Cdd:COG2956    10 GWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 430 GHQQDACDALKNWIKQNPK-----------YKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYL-----EAAHQNGDM 493
Cdd:COG2956    90 GLLDRAEELLEKLLELDPDdaealrllaeiYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLeqgdyDEAIEALEK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 494 ---IDPDL---QTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGfIRSR 567
Cdd:COG2956   170 alkLDPDCaraLLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPS-DDLL 248

                         250       260
                  ....*....|....*....|....*..
gi 1159261216 568 YNLGISCINLGAYREAVSNFLTALSLQ 594
Cdd:COG2956   249 LALADLLERKEGLEAALALLERQLRRH 275
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 476-594 9.42e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 62.90  E-value: 9.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 476 LEGVKELYLEAAHQNGDmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTR 555
Cdd:COG4783    20 YDEAEALLEKALELDPD--NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEK 97

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1159261216 556 ALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQ 594
Cdd:COG4783    98 ALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 476-594 1.17e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 63.06  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 476 LEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTR 555
Cdd:COG5010    34 ANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEK 113

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1159261216 556 ALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQ 594
Cdd:COG5010   114 ALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 400-561 1.17e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 400 AAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKykylvkskkgspgltrrmskspvdssvlegv 479
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD------------------------------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 480 kelyleaahqngdmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEI 559
Cdd:COG4235    50 ---------------NADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114


                  ..
gi 1159261216 560 QP 561
Cdd:COG4235   115 LP 116
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 353-583 3.14e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 66.65  E-value: 3.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 353 EEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQ 432
Cdd:TIGR02917  27 EAAKSYLQKNKYKAAIIQLKNALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKF 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 433 QDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMskspvdssvLEGVKELYLEAAHQNGDmiDPDLQTGLGVLFHLSGEF 512
Cdd:TIGR02917 107 QQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQ---------LELAQKSYEQALAIDPR--SLYAKLGLAQLALAENRF 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1159261216 513 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREA 583
Cdd:TIGR02917 176 DEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
523-648 2.12e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 2.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 523 LTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQrksrnqqq 602
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELD-------- 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1159261216 603 vphpaiSGNIWAALRIALSLMDQPELFQAanlgdLDVLLRAFNLDP 648
Cdd:COG0457    73 ------PDDAEALNNLGLALQALGRYEEA-----LEDYDKALELDP 107
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 350-570 3.69e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 63.18  E-value: 3.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 350 GAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNT 429
Cdd:TIGR02917 263 AHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRL 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 430 GHQQDACDALKNWIKQNP-----------KY----------KYLVKSKKGSPGL----TRR-MSK-SPVDSSvlEGVKEL 482
Cdd:TIGR02917 343 GRVDEAIATLSPALGLDPddpaalsllgeAYlalgdfekaaEYLAKATELDPENaaarTQLgISKlSQGDPS--EAIADL 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 483 yLEAAHQNGDMIDPDLqtgLGVLFHL-SGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQP 561
Cdd:TIGR02917 421 -ETAAQLDPELGRADL---LLILSYLrSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEP 496


                  ....*....
gi 1159261216 562 GFIRSRYNL 570
Cdd:TIGR02917 497 DFFPAAANL 505
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
346-451 6.61e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.54  E-value: 6.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 346 KDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVS 425
Cdd:COG4785    71 DLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                          90       100
                  ....*....|....*....|....*.
gi 1159261216 426 YTNTGHQQDACDALKNWIKQNPKYKY 451
Cdd:COG4785   151 LYYLGRYELAIADLEKALELDPNDPE 176
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 352-449 6.66e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.51  E-value: 6.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 352 FEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGH 431
Cdd:COG4783     8 YALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGD 87

                          90
                  ....*....|....*...
gi 1159261216 432 QQDACDALKNWIKQNPKY 449
Cdd:COG4783    88 YDEALALLEKALKLDPEH 105
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 276-449 2.12e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.39  E-value: 2.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 276 ALLSRNHSLEEEFERAKAAVESDTEfWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDW------- 348
Cdd:COG3914    33 EAAALAAALGLALLLLAALAEAAAA-ALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRAlalnpdn 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 349 -PGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYT 427
Cdd:COG3914   112 aEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191

                         170       180
                  ....*....|....*....|..
gi 1159261216 428 NTGHQQDACDALKNWIKQNPKY 449
Cdd:COG3914   192 DLGRLEEAIAAYRRALELDPDN 213
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 359-596 2.37e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 60.48  E-value: 2.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 359 LKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAvsytntghqqDACDA 438
Cdd:TIGR02917 578 LGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLA----------DAYAV 647

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 439 LKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELY--LEAAHQNgdmiDPDLQTGLGVLFHLSGEFNRAI 516
Cdd:TIGR02917 648 MKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAksLQKQHPK----AALGFELEGDLYLRQKDYPAAI 723

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 517 DAFNAALTVRPEDYSLWNRLGATLANGDRSeEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRK 596
Cdd:TIGR02917 724 QAYRKALKRAPSSQNAIKLHRALLASGNTA-EAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPD 802
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 359-449 1.18e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.04  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 359 LKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDA 438
Cdd:COG4783    49 LQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAA 128

                          90
                  ....*....|.
gi 1159261216 439 LKNWIKQNPKY 449
Cdd:COG4783   129 LEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 355-593 1.32e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.17  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 355 GLKRLK--EGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQ 432
Cdd:TIGR02917 164 GLAQLAlaENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEF 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 433 QDA---CDALKNWIKQNPK---YKYLVKSKKG-----SPGLTRRMSKSP--VDSSVLEGVKELYL---EAAHQNGDMI-- 494
Cdd:TIGR02917 244 EEAekhADALLKKAPNSPLahyLKALVDFQKKnyedaRETLQDALKSAPeyLPALLLAGASEYQLgnlEQAYQYLNQIlk 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 495 -DPDLQTG---LGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGAT-LANGDrSEEAVEAYTRALEIQPGFIRSRYN 569
Cdd:TIGR02917 324 yAPNSHQArrlLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAyLALGD-FEKAAEYLAKATELDPENAAARTQ 402

                         250       260
                  ....*....|....*....|....
gi 1159261216 570 LGISCINLGAYREAVSNFLTALSL 593
Cdd:TIGR02917 403 LGISKLSQGDPSEAIADLETAAQL 426
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
358-449 1.47e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 1.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 358 RLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACD 437
Cdd:COG0457    52 YLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIE 131

                          90
                  ....*....|..
gi 1159261216 438 ALKNWIKQNPKY 449
Cdd:COG0457   132 AYERALELDPDD 143
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 514-594 2.74e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.70  E-value: 2.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 514 RAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSL 593
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                  .
gi 1159261216 594 Q 594
Cdd:COG4235    81 D 81
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 342-448 3.55e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.32  E-value: 3.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 342 ENPfKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMA 421
Cdd:COG4235    12 ANP-NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                          90       100
                  ....*....|....*....|....*..
gi 1159261216 422 LAVSYTNTGHQQDACDALKNWIKQNPK 448
Cdd:COG4235    91 LGLAAFQQGDYAEAIAAWQKLLALLPA 117
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
494-561 7.50e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 53.38  E-value: 7.50e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1159261216 494 IDPDL---QTGLGVLFHLSGEFNRAIDAFNAALTVRPED-YSLWNRlGATLANGDRSEEAVEAYTRALEIQP 561
Cdd:COG4785   102 LDPDLaeaYNNRGLAYLLLGDYDAALEDFDRALELDPDYaYAYLNR-GIALYYLGRYELAIADLEKALELDP 172
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
512-648 1.35e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 52.61  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 512 FNRAIDAFNAALTvRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTAL 591
Cdd:COG4785    56 AALAAERIDRALA-LPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRAL 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1159261216 592 SLQRKsrnqqqvphpaiSGNIWAALRIALSLMDQPELFQAanlgDLDVLLRAFNLDP 648
Cdd:COG4785   135 ELDPD------------YAYAYLNRGIALYYLGRYELAIA----DLEKALELDPNDP 175
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 359-447 2.37e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.73  E-value: 2.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 359 LKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDA 438
Cdd:COG5010    65 NKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144


                  ....*....
gi 1159261216 439 LKNWIKQNP 447
Cdd:COG5010   145 LQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
359-448 2.47e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.01  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 359 LKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIvALQRCLELQPNNLKALMALAVSYTNTGHQQDACDA 438
Cdd:COG3063     3 LKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81

                          90
                  ....*....|
gi 1159261216 439 LKNWIKQNPK 448
Cdd:COG3063    82 LERALELDPS 91
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 476-648 2.61e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.84  E-value: 2.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 476 LEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTR 555
Cdd:COG3914    24 AELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRR 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 556 ALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQrksrnqqqvphpaiSGNIWAALRIALSLMDQpELFQAAnlg 635
Cdd:COG3914   104 ALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALN--------------PDFAEAYLNLGEALRRL-GRLEEA--- 165

                         170
                  ....*....|...
gi 1159261216 636 dLDVLLRAFNLDP 648
Cdd:COG3914   166 -IAALRRALELDP 177
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 476-561 5.72e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.57  E-value: 5.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 476 LEGVKELYLEAAHQNGDmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTR 555
Cdd:COG5010    70 FEESLALLEQALQLDPN--NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQR 147


                  ....*.
gi 1159261216 556 ALEIQP 561
Cdd:COG5010   148 ALGTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
372-452 1.84e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.62  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 372 EAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKY 451
Cdd:COG0457   100 DKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALL 179


                  .
gi 1159261216 452 L 452
Cdd:COG0457   180 A 180
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 377-561 2.78e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.47  E-value: 2.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 377 QDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYkylVKSK 456
Cdd:TIGR02917 460 KQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKN---LRAI 536

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 457 KGSPGLTRRMSKSpvdssvlEGVKELYLEAAHQNGDMIDPDLQtgLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRL 536
Cdd:TIGR02917 537 LALAGLYLRTGNE-------EEAVAWLEKAAELNPQEIEPALA--LAQYYLGKGQLKKALAILNEAADAAPDSPEAWLML 607

                         170       180
                  ....*....|....*....|....*.
gi 1159261216 537 GAT-LANGDrSEEAVEAYTRALEIQP 561
Cdd:TIGR02917 608 GRAqLAAGD-LNKAVSSFKKLLALQP 632
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 355-445 1.78e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.07  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 355 GLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQD 434
Cdd:COG3914   153 GEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEV 232

                          90
                  ....*....|.
gi 1159261216 435 AcDALKNWIKQ 445
Cdd:COG3914   233 Y-DRFEELLAA 242
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 370-584 2.65e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 46.47  E-value: 2.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 370 FMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNL-KALMAL--------AVSYTNTGHQqdacdALK 440
Cdd:cd24142    22 FLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGyEKYLYLgqlsggeeALQYYEKGIE-----ILE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 441 NWIKQNPKYKYLvkSKKGSPGLTRRMskspvdSSVLEGVKELYL-------------EAAHQNGDMIDPD----LQTgLG 503
Cdd:cd24142    97 EELQALQAASAE--AEEEAEELKRKL------SSALCALAEIYMtdlcdepdaeqrcEELITKALELDPTnpeaLQT-LA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 504 VLfHLS-GEFNRAIDAFNAAltvrpedYSLWNRLGATLANGDRSEEAVEAYTRALEiqpgfirSRYNLGISCINLGAYRE 582
Cdd:cd24142   168 SL-RISqQRPDEAKEALRRS-------LELWKDLKEEDEEEAEEDEAEEEDVPSYE-------FRISLAKLLIELEMYEE 232


                  ..
gi 1159261216 583 AV 584
Cdd:cd24142   233 AL 234
TPR_12 pfam13424
Tetratricopeptide repeat;
531-596 3.22e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 3.22e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1159261216 531 SLWNRLGATLANGDRSEEAVEAYTRALEIQ--------PGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRK 596
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 359-457 3.90e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 43.44  E-value: 3.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 359 LKEGDLPVTILFMEAAILQDPGD---AEAWQFLGITQAENENEQAAIVALQRCLELQPNNLK---ALMALAVSYTNTGHQ 432
Cdd:COG1729     4 LKAGDYDEAIAAFKAFLKRYPNSplaPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGDY 83

                          90       100
                  ....*....|....*....|....*
gi 1159261216 433 QDACDALKNWIKQNPKYKYLVKSKK 457
Cdd:COG1729    84 DKARATLEELIKKYPDSEAAKEARA 108
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 377-549 6.25e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.23  E-value: 6.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 377 QDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLkALMALAVSYTNTGHQQDACDALKNWIKQNPK-------- 448
Cdd:TIGR02917 698 QHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQ-NAIKLHRALLASGNTAEAVKTLEAWLKTHPNdavlrtal 776

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 449 ---YKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYL-----------EAAHQNGDMIDPDLQTgLGVLFHLSGEFNR 514
Cdd:TIGR02917 777 aelYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLelkdpraleyaERALKLAPNIPAILDT-LGWLLVEKGEADR 855

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1159261216 515 AIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEA 549
Cdd:TIGR02917 856 ALPLLRKAVNIAPEAAAIRYHLALALLATGRKAEA 890
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
376-558 1.42e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 43.75  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 376 LQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYlvks 455
Cdd:COG4785    67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAY---- 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 456 kkgspgltrrmskspvdssvlegvkelyleaAHQNgdmidpdlqtgLGVLFHLSGEFNRAIDAFNAALTVRPED--YSLW 533
Cdd:COG4785   143 -------------------------------AYLN-----------RGIALYYLGRYELAIADLEKALELDPNDpeRALW 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1159261216 534 NRL-------------------GATLANGDRsEEAVEAYTRALE 558
Cdd:COG4785   181 LYLaerkldpekalallledwaTAYLLQGDT-EEARELFKLALA 223
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 502-604 1.85e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.59  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 502 LGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRsEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYR 581
Cdd:TIGR00990 133 KGNKAYRNKDFNKAIKLYSKAIECKPDPVYYSNRAACHNALGDW-EKVVEDTTAALELDPDYSKALNRRANAYDGLGKYA 211

                          90       100
                  ....*....|....*....|...
gi 1159261216 582 EAVSNFlTALSLQRKSRNQQQVP 604
Cdd:TIGR00990 212 DALLDL-TASCIIDGFRNEQSAQ 233
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 372-449 2.02e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.25  E-value: 2.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1159261216 372 EAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKY 449
Cdd:COG5010    44 AAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDN 121
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
547-648 2.16e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.54  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 547 EEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSnFLTALSLQrksrnqqqvphpaiSGNIWAALRIALSLMDQP 626
Cdd:COG3063     9 EEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLD--------------PNNAEALLNLAELLLELG 73

                          90       100
                  ....*....|....*....|..
gi 1159261216 627 ELFQAanlgdLDVLLRAFNLDP 648
Cdd:COG3063    74 DYDEA-----LAYLERALELDP 90
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 509-587 4.94e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 4.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 509 SGEFNRAIDAFNAALTVRPEDYSLWN---RLGATLANGDRSEEAVEAYTRALEIQPGFIR---SRYNLGISCINLGAYRE 582
Cdd:COG1729     6 AGDYDEAIAAFKAFLKRYPNSPLAPDalyWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGDYDK 85


                  ....*
gi 1159261216 583 AVSNF 587
Cdd:COG1729    86 ARATL 90
TPR_1 pfam00515
Tetratricopeptide repeat;
533-563 9.22e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.02  E-value: 9.22e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1159261216 533 WNRLGATLANGDRSEEAVEAYTRALEIQPGF 563
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PRK11189 PRK11189
lipoprotein NlpI; Provisional
 502-551 1.51e-03

lipoprotein NlpI; Provisional


Pssm-ID: 236875 [Multi-domain]  Cd Length: 296  Bit Score: 41.03  E-value: 1.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1159261216 502 LGVLFHLSGEFNRAIDAFNAALTVRPE-DYSLWNRlGATLANGDRSEEAVE 551
Cdd:PRK11189  104 LGIYLTQAGNFDAAYEAFDSVLELDPTyNYAYLNR-GIALYYGGRYELAQD 153
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 404-562 1.62e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 41.05  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 404 ALQRCLELQPNNLKALMALAVSY----TNTGHQQDACDALKNWIKQNPkykylvkskkgSPGLTRRMSKSPVDS-----S 474
Cdd:COG3071   177 ALKALWKALPRAERRDPELAAAYaralIALGDHDEAERLLREALKRQW-----------DPRLVRLYGRLQGGDpakqlK 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 475 VLEGvkelyleAAHQNGDmiDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPeDYSLWNRLGATLANGDRSEEAVEAYT 554
Cdd:COG3071   246 RAEK-------WLKKHPN--DPDLLLALGRLCLRNQLWGKAREYLEAALALRP-SAEAYAELARLLEQLGDPEEAAEHYR 315


                  ....*...
gi 1159261216 555 RALEIQPG 562
Cdd:COG3071   316 KALALALG 323
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 528-648 2.24e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 528 EDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKsrnqqqvphpa 607
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD----------- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1159261216 608 isgNIWAALRIALSLMDQPELFQAanlgdLDVLLRAFNLDP 648
Cdd:COG4783    71 ---EPEARLNLGLALLKAGDYDEA-----LALLEKALKLDP 103
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 510-562 2.61e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 36.93  E-value: 2.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1159261216 510 GEFNRAIDAFNAALTVR---PEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 562
Cdd:pfam13432  11 GDYDDAAAALEAALARFpesPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPG 66
TPR_1 pfam00515
Tetratricopeptide repeat;
382-415 4.68e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 4.68e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1159261216 382 AEAWQFLGITQAENENEQAAIVALQRCLELQPNN 415
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR_12 pfam13424
Tetratricopeptide repeat;
498-559 5.66e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.21  E-value: 5.66e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261216 498 LQTGLGVLFHLSGEFNRAIDAFNAALTV--------RPEDYSLWNRLGATLANGDRSEEAVEAYTRALEI 559
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIarrllgpdHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 382-415 8.98e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.34  E-value: 8.98e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1159261216  382 AEAWQFLGITQAENENEQAAIVALQRCLELQPNN 415
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 533-563 9.71e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.34  E-value: 9.71e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1159261216  533 WNRLGATLANGDRSEEAVEAYTRALEIQPGF 563
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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