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Conserved domains on  [gi|1159261116|ref|NP_001336357|]
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kelch-like protein 24 isoform c [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 18656853)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions; similar to Mus musculus Rab9 effector protein with kelch motifs, which is a Rab9 effector required for endosome to trans-Golgi network (TGN) transport

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
34-282 8.35e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 156.47  E-value: 8.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  34 IVVVGGCErvGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN-------SRDVWIYNSQLNIW 106
Cdd:COG3055    25 VYVAGGLS--GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGanpsstpLNDVYVYDPATNTW 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 107 IRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSP-AVTSCVGKLFVIGGgpddn 185
Cdd:COG3055   103 TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKILVIGG----- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 186 tcsdkvQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKA---IYCYDPVEDYWMHVQN-TFSRqENCGMSVC 261
Cdd:COG3055   178 ------RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFsdeVEAYDPATNTWTALGElPTPR-HGHAAVLT 250

                         250       260
                  ....*....|....*....|.
gi 1159261116 262 NGKIYILGGRRENGEATDTIL 282
Cdd:COG3055   251 DGKVYVIGGETKPGVRTPLVT 271
Kelch smart00612
Kelch domain;
264-310 3.38e-06

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 43.32  E-value: 3.38e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1159261116  264 KIYILGGRReNGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIH 310
Cdd:smart00612   1 KIYVVGGFD-GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
34-282 8.35e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 156.47  E-value: 8.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  34 IVVVGGCErvGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN-------SRDVWIYNSQLNIW 106
Cdd:COG3055    25 VYVAGGLS--GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGanpsstpLNDVYVYDPATNTW 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 107 IRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSP-AVTSCVGKLFVIGGgpddn 185
Cdd:COG3055   103 TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKILVIGG----- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 186 tcsdkvQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKA---IYCYDPVEDYWMHVQN-TFSRqENCGMSVC 261
Cdd:COG3055   178 ------RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFsdeVEAYDPATNTWTALGElPTPR-HGHAAVLT 250

                         250       260
                  ....*....|....*....|.
gi 1159261116 262 NGKIYILGGRRENGEATDTIL 282
Cdd:COG3055   251 DGKVYVIGGETKPGVRTPLVT 271
PHA03098 PHA03098
kelch-like protein; Provisional
 46-285 1.04e-27

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 112.55  E-value: 1.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  46 FNLPYTECYDPVTGEWKSLAKLPEFTKSEyavCALRNDILVS-GGRIN----SRDVWIYNSQLNIWIRVASLNKGRWRHK 120
Cdd:PHA03098  261 IFTYNYITNYSPLSEINTIIDIHYVYCFG---SVVLNNVIYFiGGMNKnnlsVNSVVSYDTKTKSWNKVPELIYPRKNPG 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 121 MAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNS 200
Cdd:PHA03098  338 VTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNK 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 201 WLLRAAIPIAKRCITAVSLNNLIYVAGGLT--------KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRR 272
Cdd:PHA03098  418 WSKGSPLPISHYGGCAIYHDGKIYVIGGISyidnikvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDK 497

                         250
                  ....*....|...
gi 1159261116 273 eNGEATDTILCYD 285
Cdd:PHA03098  498 -YEYYINEIEVYD 509
Kelch smart00612
Kelch domain;
127-171 2.35e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 60.65  E-value: 2.35e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1159261116  127 KVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSC 171
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 118-160 1.47e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 55.70  E-value: 1.47e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1159261116 118 RHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLK 160
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 126-234 9.12e-07

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 49.79  E-value: 9.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 126 GKVYVVGGYDGQNRLSSVECYD--SFSNRWTEVAPLK-EAVSSPAVTSCVGKLFVIGG--GPDDNTCSDKVQSYDPETNS 200
Cdd:TIGR03548 125 GKIYVGGGNANGKPSNKFYCLDlsNDTSGWEELPEFPgEARVQPVCQALHGKLYVFGGfqLGGDAIIYTDGYAYSPKTNT 204

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1159261116 201 W------LLRAAIPIAKRCITAVSLN-NLIYVAGGLTKAIY 234
Cdd:TIGR03548 205 WqtvadpVLSDGEPITLLGGNSVKLGdSLMLVIGGVNYDIF 245
Kelch smart00612
Kelch domain;
264-310 3.38e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 43.32  E-value: 3.38e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1159261116  264 KIYILGGRReNGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIH 310
Cdd:smart00612   1 KIYVVGGFD-GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
262-309 9.79e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.20  E-value: 9.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1159261116 262 NGKIYILGGR-RENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTI 309
Cdd:pfam13415   1 GDKLYIFGGLgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
34-282 8.35e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 156.47  E-value: 8.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  34 IVVVGGCErvGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN-------SRDVWIYNSQLNIW 106
Cdd:COG3055    25 VYVAGGLS--GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGanpsstpLNDVYVYDPATNTW 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 107 IRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSP-AVTSCVGKLFVIGGgpddn 185
Cdd:COG3055   103 TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKILVIGG----- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 186 tcsdkvQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKA---IYCYDPVEDYWMHVQN-TFSRqENCGMSVC 261
Cdd:COG3055   178 ------RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFsdeVEAYDPATNTWTALGElPTPR-HGHAAVLT 250

                         250       260
                  ....*....|....*....|.
gi 1159261116 262 NGKIYILGGRRENGEATDTIL 282
Cdd:COG3055   251 DGKVYVIGGETKPGVRTPLVT 271
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
59-309 2.09e-41

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.91  E-value: 2.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  59 GEWKSLAKLPeFTKSEYAVCALRNDILVSGGRIN---SRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLL-GKVYVVGGY 134
Cdd:COG3055     1 ATWSSLPDLP-TPRSEAAAALLDGKVYVAGGLSGgsaSNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQdGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 135 DGQNR----LSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGpDDNTCSDKVQSYDPETNSWLLRAAIPIA 210
Cdd:COG3055    80 TGANPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGW-DDGGNVAWVEVYDPATGTWTQLAPLPTP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 211 KRCITAVSL-NNLIYVAGGLTKAIYcydpvEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRrenGEATDTILCYDPATS 289
Cdd:COG3055   159 RDHLAAAVLpDGKILVIGGRNGSGF-----SNTWTTLAPLPTARAGHAAAVLGGKILVFGGE---SGFSDEVEAYDPATN 230

                         250       260
                  ....*....|....*....|
gi 1159261116 290 IITGVAAMPRPVSYHGCVTI 309
Cdd:COG3055   231 TWTALGELPTPRHGHAAVLT 250
PHA03098 PHA03098
kelch-like protein; Provisional
 46-285 1.04e-27

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 112.55  E-value: 1.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  46 FNLPYTECYDPVTGEWKSLAKLPEFTKSEyavCALRNDILVS-GGRIN----SRDVWIYNSQLNIWIRVASLNKGRWRHK 120
Cdd:PHA03098  261 IFTYNYITNYSPLSEINTIIDIHYVYCFG---SVVLNNVIYFiGGMNKnnlsVNSVVSYDTKTKSWNKVPELIYPRKNPG 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 121 MAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNS 200
Cdd:PHA03098  338 VTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNK 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 201 WLLRAAIPIAKRCITAVSLNNLIYVAGGLT--------KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRR 272
Cdd:PHA03098  418 WSKGSPLPISHYGGCAIYHDGKIYVIGGISyidnikvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDK 497

                         250
                  ....*....|...
gi 1159261116 273 eNGEATDTILCYD 285
Cdd:PHA03098  498 -YEYYINEIEVYD 509
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
34-195 5.53e-23

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 95.99  E-value: 5.53e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  34 IVVVGGceRVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSrdvwiynSQLNIWIRVASLN 113
Cdd:COG3055   124 IYVVGG--WDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDGKILVIGGRNGS-------GFSNTWTTLAPLP 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 114 KGRWRHKMAVLLGKVYVVGGYDGQNrlSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQS 193
Cdd:COG3055   195 TARAGHAAAVLGGKILVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTS 272


                  ..
gi 1159261116 194 YD 195
Cdd:COG3055   273 AE 274
PHA03098 PHA03098
kelch-like protein; Provisional
 175-312 3.14e-16

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 79.04  E-value: 3.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 175 LFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL-----TKAIYCYDPVEDYWMHVQNT 249
Cdd:PHA03098  297 IYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIynsisLNTVESWKPGESKWREEPPL 376

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1159261116 250 fsRQENCGMSVC--NGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRY 312
Cdd:PHA03098  377 --IFPRYNPCVVnvNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGK 439
PHA03098 PHA03098
kelch-like protein; Provisional
 34-201 1.80e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 70.57  E-value: 1.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  34 IVVVGGCErvGGFNLPYTECYDPVTGEWKSLAKLpEFTKSEYAVCALRNDILVSGGRI----NSRDVWIYNSQLNIWIRV 109
Cdd:PHA03098  345 IYVIGGIY--NSISLNTVESWKPGESKWREEPPL-IFPRYNPCVVNVNNLIYVIGGISkndeLLKTVECFSLNTNKWSKG 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 110 ASLNKGRWRHKMAVLLGKVYVVGGY---DGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNT 186
Cdd:PHA03098  422 SPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYY 501

                         170
                  ....*....|....*
gi 1159261116 187 cSDKVQSYDPETNSW 201
Cdd:PHA03098  502 -INEIEVYDDKTNTW 515
Kelch smart00612
Kelch domain;
127-171 2.35e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 60.65  E-value: 2.35e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1159261116  127 KVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSC 171
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 118-160 1.47e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 55.70  E-value: 1.47e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1159261116 118 RHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLK 160
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PLN02193 PLN02193
nitrile-specifier protein
 83-287 3.60e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 57.66  E-value: 3.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  83 DILVSGGRINSRDVWIynSQLNIWIRVASLNKG---RWRHKMAVLLGKVYVVGGYDGQNRLSSVECY--DSFSNRWTeVA 157
Cdd:PLN02193  132 DVLHSLGAYISLPSTP--KLLGKWIKVEQKGEGpglRCSHGIAQVGNKIYSFGGEFTPNQPIDKHLYvfDLETRTWS-IS 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 158 PlkeAVSSPAVTSCVG-KLFVIG------GGPDDNTCSDKVQSYDPETNSWLLRAAI---PIAKRCITAVSLNNLIYVAG 227
Cdd:PLN02193  209 P---ATGDVPHLSCLGvRMVSIGstlyvfGGRDASRQYNGFYSFDTTTNEWKLLTPVeegPTPRSFHSMAADEENVYVFG 285

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1159261116 228 GLT-----KAIYCYDPVEDYWMHVQN---TFSRQENCGMSVCNGKIYILGGRreNGEATDTILCYDPA 287
Cdd:PLN02193  286 GVSatarlKTLDSYNIVDKKWFHCSTpgdSFSIRGGAGLEVVQGKVWVVYGF--NGCEVDDVHYYDPV 351
PHA03098 PHA03098
kelch-like protein; Provisional
 27-165 7.18e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 56.70  E-value: 7.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  27 STGYSEVIVVVGGCERvGGFNLPYTECYDPVTGEWKSLAKLPeftKSEYAVCAL--RNDILVSGGRINSRD------VWI 98
Cdd:PHA03098  385 VVNVNNLIYVIGGISK-NDELLKTVECFSLNTNKWSKGSPLP---ISHYGGCAIyhDGKIYVIGGISYIDNikvyniVES 460

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1159261116  99 YNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSS 165
Cdd:PHA03098  461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGS 527
PLN02193 PLN02193
nitrile-specifier protein
 17-181 1.59e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 55.35  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  17 VTLLKLLSIRSTGYSEVIVVVGGCERVGGFNLPYTecYDPVTGEWKSLAKLPE--FTKSEYAVCALRNDILVSGG----- 89
Cdd:PLN02193  214 VPHLSCLGVRMVSIGSTLYVFGGRDASRQYNGFYS--FDTTTNEWKLLTPVEEgpTPRSFHSMAADEENVYVFGGvsata 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  90 RINSRDVwiYNSQLNIWIRVASLNKG---RWRHKMAVLLGKVYVVGGYDGqNRLSSVECYDSFSNRWTEVAPLKEAVSSP 166
Cdd:PLN02193  292 RLKTLDS--YNIVDKKWFHCSTPGDSfsiRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQVETFGVRPSER 368

                         170
                  ....*....|....*..
gi 1159261116 167 AV--TSCVGKLFVIGGG 181
Cdd:PLN02193  369 SVfaSAAVGKHIVIFGG 385
PHA02713 PHA02713
hypothetical protein; Provisional
 49-201 2.03e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 55.40  E-value: 2.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  49 PYTECYDPVTGEWKSLAKLPEFTKSeYAVCALRNDILVSGG----RINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVL 124
Cdd:PHA02713  272 PCILVYNINTMEYSVISTIPNHIIN-YASAIVDNEIIIAGGynfnNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVI 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 125 LGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGP-----------------DDNTC 187
Cdd:PHA02713  351 DDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTehidytsvhhmnsidmeEDTHS 430

                         170
                  ....*....|....
gi 1159261116 188 SDKVQSYDPETNSW 201
Cdd:PHA02713  431 SNKVIRYDTVNNIW 444
PLN02153 PLN02153
epithiospecifier protein
 23-201 1.15e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 52.68  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  23 LSIRSTGYSEVIVVVGGCERVGGFNLPYTecYDPVTGEWKSLAKLPEFTKSE----YAVCALRNDILV-----SGGRINS 93
Cdd:PLN02153   77 LGVRMVAVGTKLYIFGGRDEKREFSDFYS--YDTVKNEWTFLTKLDEEGGPEartfHSMASDENHVYVfggvsKGGLMKT 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  94 ----RDVWIYNSQLNIWIRVASLNKG---RWRHKMAVLLGKVYVVGGY------DGQNRLSS--VECYDSFSNRWTEVAP 158
Cdd:PLN02153  155 perfRTIEAYNIADGKWVQLPDPGENfekRGGAGFAVVQGKIWVVYGFatsilpGGKSDYESnaVQFFDPASGKWTEVET 234

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1159261116 159 L--KEAVSSPAVTSCVGKLFVIGGG---PDDN------TCSDKVQSYDPETNSW 201
Cdd:PLN02153  235 TgaKPSARSVFAHAVVGKYIIIFGGevwPDLKghlgpgTLSNEGYALDTETLVW 288
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 126-234 9.12e-07

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 49.79  E-value: 9.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 126 GKVYVVGGYDGQNRLSSVECYD--SFSNRWTEVAPLK-EAVSSPAVTSCVGKLFVIGG--GPDDNTCSDKVQSYDPETNS 200
Cdd:TIGR03548 125 GKIYVGGGNANGKPSNKFYCLDlsNDTSGWEELPEFPgEARVQPVCQALHGKLYVFGGfqLGGDAIIYTDGYAYSPKTNT 204

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1159261116 201 W------LLRAAIPIAKRCITAVSLN-NLIYVAGGLTKAIY 234
Cdd:TIGR03548 205 WqtvadpVLSDGEPITLLGGNSVKLGdSLMLVIGGVNYDIF 245
Kelch smart00612
Kelch domain;
264-310 3.38e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 43.32  E-value: 3.38e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1159261116  264 KIYILGGRReNGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIH 310
Cdd:smart00612   1 KIYVVGGFD-GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
150-234 8.52e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.93  E-value: 8.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 150 SNRWTEVAPLKEAVSSPAVTSCV-GKLFVIGGGPDDNTCS-----DKVQSYDPETNSWL-LRAAIPIAKRCITAVSLNN- 221
Cdd:PRK14131   61 SKGWTKIAAFPGGPREQAVAAFIdGKLYVFGGIGKTNSEGspqvfDDVYKYDPKTNSWQkLDTRSPVGLAGHVAVSLHNg 140

                          90
                  ....*....|...
gi 1159261116 222 LIYVAGGLTKAIY 234
Cdd:PRK14131  141 KAYITGGVNKNIF 153
PLN02193 PLN02193
nitrile-specifier protein
 86-201 2.85e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116  86 VSGGRINSRD---VWIYNSQLNIWIRVASLNKG---RWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPL 159
Cdd:PLN02193  233 VFGGRDASRQyngFYSFDTTTNEWKLLTPVEEGptpRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTP 312

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1159261116 160 KEAVSS---PAVTSCVGKLFVIGGGpddNTCS-DKVQSYDPETNSW 201
Cdd:PLN02193  313 GDSFSIrggAGLEVVQGKVWVVYGF---NGCEvDDVHYYDPVQDKW 355
Kelch_3 pfam13415
Galactose oxidase, central domain;
262-309 9.79e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.20  E-value: 9.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1159261116 262 NGKIYILGGR-RENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTI 309
Cdd:pfam13415   1 GDKLYIFGGLgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 164-201 2.25e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 2.25e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1159261116 164 SSPAVTSCVGKLFVIGGGpDDNTCSDKVQSYDPETNSW 201
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGF-DGNQSLNSVEVYDPETNTW 39
Kelch_3 pfam13415
Galactose oxidase, central domain;
126-170 3.22e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.04  E-value: 3.22e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1159261116 126 GKVYVVGGYD--GQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTS 170
Cdd:pfam13415   2 DKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
PHA02790 PHA02790
Kelch-like protein; Provisional
 100-288 4.52e-04

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 41.57  E-value: 4.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 100 NSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQnrlSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIG 179
Cdd:PHA02790  293 NYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNP---TSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIG 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 180 GGPDDNTCSDKVQsydPETNSWLLRAAI--PIAKRCitAVSLNNLIYVAgGLTKAIYCydPVEDYWMHVQNTFSRQENCG 257
Cdd:PHA02790  370 GHSETDTTTEYLL---PNHDQWQFGPSTyyPHYKSC--ALVFGRRLFLV-GRNAEFYC--ESSNTWTLIDDPIYPRDNPE 441

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1159261116 258 MSVCNGKIYILGGRREnGEATDTILCYDPAT 288
Cdd:PHA02790  442 LIIVDNKLLLIGGFYR-GSYIDTIEVYNNRT 471
Kelch smart00612
Kelch domain;
174-221 7.71e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.77  E-value: 7.71e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1159261116  174 KLFVIGGGpDDNTCSDKVQSYDPETNSWLLRAAIPIAkRCITAVSLNN 221
Cdd:smart00612   1 KIYVVGGF-DGGQRLKSVEVYDPETNKWTPLPSMPTP-RSGHGVAVIN 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 255-298 9.02e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 9.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1159261116 255 NCGMSVCNGKIYILGGRReNGEATDTILCYDPATSIITGVAAMP 298
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFD-GNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 115-159 1.26e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.16  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1159261116 115 GRWRHKMAVLLGKVYVVGGYDGQNRLSS--VECYDSFSNRWTEVAPL 159
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSsdVLVYDPETNVWTEVPRL 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 73-113 1.42e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 1.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1159261116  73 SEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVASLN 113
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQslnSVEVYDPETNTWSKLPSMP 46
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 153-234 1.77e-03

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 39.62  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 153 WTEVAPLKEAVSSPAVTS-CVGKLFVIGG-GPDDNTCS----DKVQSYDPETNSWL-LRAAIPIAKRCITAVSLNN-LIY 224
Cdd:TIGR03547  43 WQKIADFPGGPRNQAVAAaIDGKLYVFGGiGKANSEGSpqvfDDVYRYDPKKNSWQkLDTRSPVGLLGASGFSLHNgQAY 122

                          90
                  ....*....|
gi 1159261116 225 VAGGLTKAIY 234
Cdd:TIGR03547 123 FTGGVNKNIF 132
Kelch smart00612
Kelch domain;
33-82 2.06e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.61  E-value: 2.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1159261116   33 VIVVVGGCErvGGFNLPYTECYDPVTGEWKSLAKLPEfTKSEYAVCALRN 82
Cdd:smart00612   1 KIYVVGGFD--GGQRLKSVEVYDPETNKWTPLPSMPT-PRSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
116-160 2.22e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.39  E-value: 2.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1159261116 116 RWRHKMAVLLGKVYVVGGYDGQ-NRLSSVECYDSFSNRWTEVAPLK 160
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPLTKSWEELPPLP 47
PRK14131 PRK14131
N-acetylneuraminate epimerase;
201-274 2.42e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 39.23  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159261116 201 WLLRAAIPIAKRC-ITAVSLNNLIYVAGGLTKA-----------IYCYDPVEDYWMHVQNTFSRqencGMSVC------N 262
Cdd:PRK14131   64 WTKIAAFPGGPREqAVAAFIDGKLYVFGGIGKTnsegspqvfddVYKYDPKTNSWQKLDTRSPV----GLAGHvavslhN 139

                          90
                  ....*....|..
gi 1159261116 263 GKIYILGGRREN 274
Cdd:PRK14131  140 GKAYITGGVNKN 151
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 212-248 2.51e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 2.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1159261116 212 RCITAVSLNNLIYVAGG-----LTKAIYCYDPVEDYWMHVQN 248
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGfdgnqSLNSVEVYDPETNTWSKLPS 44
Kelch smart00612
Kelch domain;
84-126 2.97e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 2.97e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1159261116   84 ILVSGGRINS---RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLG 126
Cdd:smart00612   2 IYVVGGFDGGqrlKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
173-219 5.03e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.57  E-value: 5.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1159261116 173 GKLFVIGG-GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSL 219
Cdd:pfam13415   2 DKLYIFGGlGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
262-298 5.64e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.51  E-value: 5.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1159261116 262 NGKIYILGGRRENGEATDTILCYDPATSIITGVAAMP 298
Cdd:pfam13418  12 DDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSLP 48
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 32-68 7.43e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.12  E-value: 7.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1159261116  32 EVIVVVGGCerVGGFNLPYTECYDPVTGEWKSLAKLP 68
Cdd:pfam01344  12 GKIYVIGGF--DGNQSLNSVEVYDPETNTWSKLPSMP 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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