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Conserved domains on  [gi|115528184|gb|AAI24797|]
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Zgc:154031 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
171-312 4.47e-06

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 4.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 171 GIHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVcVGDDGHNDWIFSIAWISD-TMAVSGSRDGSMGLWEISedvlsqa 249
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDD-GTVRLWDLATGKLL-RTLTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLA------- 360

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115528184 250 ekrqnvEGVPGYSHISHRAlkdipkeythpyncKVRALAFNNSHKELGAVSLDGYFHLWKAED 312
Cdd:COG2319  361 ------TGELLRTLTGHTG--------------AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
171-312 4.47e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 4.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 171 GIHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVcVGDDGHNDWIFSIAWISD-TMAVSGSRDGSMGLWEISedvlsqa 249
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDD-GTVRLWDLATGKLL-RTLTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLA------- 360

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115528184 250 ekrqnvEGVPGYSHISHRAlkdipkeythpyncKVRALAFNNSHKELGAVSLDGYFHLWKAED 312
Cdd:COG2319  361 ------TGELLRTLTGHTG--------------AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-309 9.01e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 9.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 172 IHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVCVGDdGHNDWIFSIAWISDT-MAVSGSRDGSMGLWEISEDVLSQAe 250
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQT- 256

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 115528184 251 krqnvegVPGYSHIshralkdipkeythpynckVRALAFNNSHKELGAVSLDGYFHLWK 309
Cdd:cd00200  257 -------LSGHTNS-------------------VTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
171-312 4.47e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 4.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 171 GIHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVcVGDDGHNDWIFSIAWISD-TMAVSGSRDGSMGLWEISedvlsqa 249
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDD-GTVRLWDLATGKLL-RTLTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLA------- 360

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115528184 250 ekrqnvEGVPGYSHISHRAlkdipkeythpyncKVRALAFNNSHKELGAVSLDGYFHLWKAED 312
Cdd:COG2319  361 ------TGELLRTLTGHTG--------------AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-309 9.01e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 9.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 172 IHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVCVGDdGHNDWIFSIAWISDT-MAVSGSRDGSMGLWEISEDVLSQAe 250
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQT- 256

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 115528184 251 krqnvegVPGYSHIshralkdipkeythpynckVRALAFNNSHKELGAVSLDGYFHLWK 309
Cdd:cd00200  257 -------LSGHTNS-------------------VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
171-312 1.53e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 171 GIHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVCVGDdGHNDWIFSIAWISD-TMAVSGSRDGSMGLWEISEdvlsqa 249
Cdd:COG2319  206 AVRSVAFSPDGKLLASGSAD-GTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDgRLLASGSADGTVRLWDLAT------ 277

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115528184 250 ekrqnvegvpgyshishralKDIPKEYTHPYNcKVRALAFNNSHKELGAVSLDGYFHLWKAED 312
Cdd:COG2319  278 --------------------GELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
171-312 3.00e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 3.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 171 GIHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVCVGDdGHNDWIFSIAWISD-TMAVSGSRDGSMGLWEISedvlsqa 249
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSAD-GTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDgKLLASGSDDGTVRLWDLA------- 318

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115528184 250 ekrqnvEGVPGYSHISHRAlkdipkeythpyncKVRALAFNNSHKELGAVSLDGYFHLWKAED 312
Cdd:COG2319  319 ------TGKLLRTLTGHTG--------------AVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
171-312 4.64e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 4.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 171 GIHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVCVGDdGHNDWIFSIAWISD-TMAVSGSRDGSMGLWEISedvlsqa 249
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDD-GTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDgKLLASGSADGTVRLWDLA------- 234

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115528184 250 ekrqnvEGVPGYSHISHRALkdipkeythpynckVRALAFNNSHKELGAVSLDGYFHLWKAED 312
Cdd:COG2319  235 ------TGKLLRTLTGHSGS--------------VRSVAFSPDGRLLASGSADGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 170-308 5.04e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 5.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 170 CGIHAIELNPSRTLLATGGDNpNSLAVYRLPTldPVCVGD-DGHNDWIFSIAWISD-TMAVSGSRDGSMGLWEISedvls 247
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRD-KTIKVWDVET--GKCLTTlRGHTDWVNSVAFSPDgTFVASSSQDGTIKLWDLR----- 165

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115528184 248 qaekrqnvEGVPGYSHISHralkdipkeythpyNCKVRALAFNNSHKELGAVSLDGYFHLW 308
Cdd:cd00200  166 --------TGKCVATLTGH--------------TGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
171-312 2.97e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 171 GIHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVCVGDdGHNDWIFSIAWISD-TMAVSGSRDGSMGLWEisedvLSQA 249
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDgKLLASGSDDGTVRLWD-----LATG 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115528184 250 EKRQNVEGVPGYshishralkdipkeythpynckVRALAFNNSHKELGAVSLDGYFHLWKAED 312
Cdd:COG2319  195 KLLRTLTGHTGA----------------------VRSVAFSPDGKLLASGSADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-400 7.46e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 7.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 171 GIHAIELNPSRTLLATGGDNpNSLAVYRLPTLDP-----------------------VCVGDD----------------- 210
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGD-GTIKVWDLETGELlrtlkghtgpvrdvaasadgtylASGSSDktirlwdletgecvrtl 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 211 -GHNDWIFSIAWISD-TMAVSGSRDGSMGLWEIsedvlSQAEKRQNVEGVPGYshishralkdipkeythpynckVRALA 288
Cdd:cd00200   90 tGHTSYVSSVAFSPDgRILSSSSRDKTIKVWDV-----ETGKCLTTLRGHTDW----------------------VNSVA 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115528184 289 FNNSHKELGAVSLDGYFHLWkaeDNLSKELSTKLPYCKENV-CLAYGLDWSVYAVGSQAHVSFLDPRQSSQNIKSVSSRE 367
Cdd:cd00200  143 FSPDGTFVASSSQDGTIKLW---DLRTGKCVATLTGHTGEVnSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 115528184 368 rgSGIRSVSFYEH--IVTVGTGQGSLLFYDIRAQR 400
Cdd:cd00200  220 --NGVNSVAFSPDgyLLASGSEDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-240 3.90e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 3.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115528184 171 GIHAIELNPSRTLLATGGDNpNSLAVYRLPTLDPVCVGDdGHNDWIFSIAWISDTMA-VSGSRDGSMGLWE 240
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSED-GTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRlASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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