|
Name |
Accession |
Description |
Interval |
E-value |
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
35-469 |
0e+00 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 618.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWGDLGANWAET-KDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGG 113
Cdd:cd16161 1 KPNFLLLFADDLGWGDLGANWAPNaILTPNLDKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVGHNFLPTSVGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHDmgctdtpgynhppcpacprgdrpsrsler 193
Cdd:cd16161 81 LPLNETTLAEVLRQAGYATGMIGKWHLGQREAYLPNSRGFDYYFGIPFSHD----------------------------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalplyenlniveqpvnlSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPISRTQL-SAVLRGRRPYGAG 272
Cdd:cd16161 132 -----------------------SSLADRYAQFATDFIQRASAKDRPFFLYAALAHVHVPLANLPRfQSPTSGRGPYGDA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 273 LREMDSLVGQIKDKVDR-TAKENTFLWFTGDNGPWAQKCELAgsVGPFTGLWQTHQGGSPAKQTTWEGGHRVPALAYWPG 351
Cdd:cd16161 189 LQEMDDLVGQIMDAVKHaGLKDNTLTWFTSDNGPWEVKCELA--VGPGTGDWQGNLGGSVAKASTWEGGHREPAIVYWPG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 352 RVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSGAAGeFGALQTVRLGSYKAF 431
Cdd:cd16161 267 RIPANSTSAALVSTLDIFPTVVALAGASLPPGRIYDGKDLSPVLFGGSKTGHRCLFHPNSGAAG-AGALSAVRCGDYKAH 345
|
410 420 430
....*....|....*....|....*....|....*...
gi 115503411 432 YVSGGAKACDGDVGREQHHDPPLIFNLEDDVAEAVPLD 469
Cdd:cd16161 346 YATGGALACCGSTGPKLYHDPPLLFDLEVDPAESFPLT 383
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
35-468 |
7.73e-174 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 495.93 E-value: 7.73e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHN-FAVTSVGG 113
Cdd:cd16026 1 KPNIVVILADDLGYGDLGCYGSPLIKTPNIDRLAAEGVRFTDFYAAAPVCSPSRAALLTGRYPVRVGLPGVvGPPGSKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPAcprgdrpsrsler 193
Cdd:cd16026 81 LPPDEITIAEVLKKAGYRTALVGKWHLGHQPEFLPTRHGFDEYFGIPYSNDMWPFPLYRNDPPGPLP------------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalPLYENLNIVEQPVNLSSLAHKYAEKAIQFIQhaSASGRPFLLYMGLAHMHVPISRTQLSAVLRGRRPYGAGL 273
Cdd:cd16026 148 --------PLMENEEVIEQPADQSSLTQRYTDEAVDFIE--RNKDQPFFLYLAHTMPHVPLFASEKFKGRSGAGLYGDVV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 274 REMDSLVGQIKDKVDRT-AKENTFLWFTGDNGPWAQKCELAGSVGPFTGlwqthqggspAKQTTWEGGHRVPALAYWPGR 352
Cdd:cd16026 218 EELDWSVGRILDALKELgLEENTLVIFTSDNGPWLEYGGHGGSAGPLRG----------GKGTTWEGGVRVPFIAWWPGV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 353 VPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSGaagefGALQTVRLGSYKAFY 432
Cdd:cd16026 288 IPAGTVSDELASTMDLLPTLAALAGAPLPEDRVIDGKDISPLLLGGSKSPPHPFFYYYDG-----GDLQAVRSGRWKLHL 362
|
410 420 430
....*....|....*....|....*....|....*.
gi 115503411 433 VSGGAKACDGDVGREQHHDPPLIFNLEDDVAEAVPL 468
Cdd:cd16026 363 PTTYRTGTDPGGLDPTKLEPPLLYDLEEDPGETYNV 398
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
35-515 |
1.51e-119 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 360.61 E-value: 1.51e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHN-FAVTSVGG 113
Cdd:cd16158 1 PPNIVLLFADDLGYGDLGCYGHPSSSTPNLDRLAANGLRFTDFYSSSPVCSPSRAALLTGRYQVRSGVYPGvFYPGSRGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHL--GHHGPYHPNFRGFDYYFGIPYSHDMG-CTDTPGYnhPPCPACPRGDRPSrs 190
Cdd:cd16158 81 LPLNETTIAEVLKTVGYQTAMVGKWHLgvGLNGTYLPTHQGFDHYLGIPYSHDQGpCQNLTCF--PPNIPCFGGCDQG-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 191 lerdcytDVALPLYENLNIVEQPVNLSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPISRTQLSAVLRGRRPYG 270
Cdd:cd16158 157 -------EVPCPLFYNESIVQQPVDLLTLEERYAKFAKDFIADNAKEGKPFFLYYASHHTHYPQFAGQKFAGRSSRGPFG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 271 AGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGPWAQKCELAGSvgpfTGLWQTHQGgspakqTTWEGGHRVPALAYW 349
Cdd:cd16158 230 DALAELDGSVGELLQTLKENGiDNNTLVFFTSDNGPSTMRKSRGGN----AGLLKCGKG------TTYEGGVREPAIAYW 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 350 PGRVPVNVTStALLSVLDIFPTVVALAGASLPqDRHFDGLDASEVLFGWSQTGHRVLFHPNSGAAGEFGALqTVRLGSYK 429
Cdd:cd16158 300 PGRIKPGVTH-ELASTLDILPTIAKLAGAPLP-NVTLDGVDMSPILFEQGKSPRQTFFYYPTSPDPDKGVF-AVRWGKYK 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 430 AFYVSGGA--------KACDGDVGReQHHDPPLIFNLEDDVAEAVPLDRGSaEYQGVLPKVREILADVLLDIA-GDntSR 500
Cdd:cd16158 377 AHFYTQGAahsgttpdKDCHPSAEL-TSHDPPLLFDLSQDPSENYNLLGLP-EYNQVLKQIQQVKERFEASMKfGE--SE 452
|
490
....*....|....*
gi 115503411 501 ADYTRHPSVTPCCNP 515
Cdd:cd16158 453 INKGEDPALEPCCKP 467
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
35-468 |
7.12e-113 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 342.10 E-value: 7.12e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGV---THNFAVTSV 111
Cdd:cd16160 1 KPNIVLFFADDMGYGDLASYGHPTQERGPIDDMAAEGIRFTQAYSADSVCTPSRAALLTGRLPIRSGMyggTRVFLPWDI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 112 GGLPLNETTLAEVLQQAGYVTGMIGKWHLG-----HHGPYH-PNFRGFDYY-FGIPYSHDMGCTDTPGYNhppcpacprg 184
Cdd:cd16160 81 GGLPKTEVTMAEALKEAGYTTGMVGKWHLGinennHSDGAHlPSHHGFDFVgTNLPFTNSWACDDTGRHV---------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 185 DRPSRSLerdCYtdvalpLYENLNIVEQPVNLSSLAHKYAEKAIQFIqHASASgRPFLLYMGLAHMHVPI--SRTQLSAV 262
Cdd:cd16160 151 DFPDRSA---CF------LYYNDTIVEQPIQHEHLTETLVGDAKSFI-EDNQE-NPFFLYFSFPQTHTPLfaSKRFKGKS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 263 LRGRrpYGAGLREMDSLVGQIKDK-VDRTAKENTFLWFTGDNGPWAQKCELAGSVGPFTGlwqthqggspAKQTTWEGGH 341
Cdd:cd16160 220 KRGR--YGDNINEMSWAVGEVLDTlVDTGLDQNTLVFFLSDHGPHVEYCLEGGSTGGLKG----------GKGNSWEGGI 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 342 RVPALAYWPGRVPVNVtSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHR-VLFHPNSgaagefgAL 420
Cdd:cd16160 288 RVPFIAYWPGTIKPRV-SHEVVSTMDIFPTFVDLAGGTLPTDRIYDGLSITDLLLGEADSPHDdILYYCCS-------RL 359
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115503411 421 QTVRLGSYKAFYVSGG-------AKACDGDVGREQH-------------HDPPLIFNLEDDVAEAVPL 468
Cdd:cd16160 360 MAVRYGSYKIHFKTQPlpsqeslDPNCDGGGPLSDYivcydcedecvtkHNPPLIFDVEKDPGEQYPL 427
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
35-488 |
1.23e-104 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 321.72 E-value: 1.23e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNG--VTHNFAVTS-- 110
Cdd:cd16157 1 KPNIILMLMDDMGWGDLGVFGEPSRETPNLDRMAAEGMLFTDFYSANPLCSPSRAALLTGRLPIRNGfyTTNAHARNAyt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 111 ----VGGLPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHdMGCTDTPgynhppcpacprgDR 186
Cdd:cd16157 81 pqniVGGIPDSEILLPELLKKAGYRNKIVGKWHLGHRPQYHPLKHGFDEWFGAPNCH-FGPYDNK-------------AY 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 187 PSRSLERDcyTDVALPLYENLNIvEQPVNLSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPI--SRTQLSAVLR 264
Cdd:cd16157 147 PNIPVYRD--WEMIGRYYEEFKI-DKKTGESNLTQIYLQEALEFIEKQHDAQKPFFLYWAPDATHAPVyaSKPFLGTSQR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 265 GRrpYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNG-PWAQKCELAGSVGPFTGlwqthqggspAKQTTWEGGHR 342
Cdd:cd16157 224 GL--YGDAVMELDSSVGKILESLKSLGiENNTFVFFSSDNGaALISAPEQGGSNGPFLC----------GKQTTFEGGMR 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 343 VPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSgaagefgALQT 422
Cdd:cd16157 292 EPAIAWWPGHIKPGQVSHQLGSLMDLFTTSLALAGLPIPSDRAIDGIDLLPVLLNGKEKDRPIFYYRGD-------ELMA 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 423 VRLGSYKAFY---------VSGGAKACDG-DVG------REQHHDPPLIFNLEDDVAEAVPLDRGSAEYQGVLPKVREIL 486
Cdd:cd16157 365 VRLGQYKAHFwtwsnsweeFRKGINFCPGqNVPgvtthnQTDHTKLPLLFHLGRDPGEKYPISFKSAEYKQAMPRISKVV 444
|
..
gi 115503411 487 AD 488
Cdd:cd16157 445 QQ 446
|
|
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
35-488 |
2.03e-102 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 317.69 E-value: 2.03e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHN------FAV 108
Cdd:cd16159 1 KPNIVLFMADDLGIGDVGCFGNDTIRTPNIDRLAKEGVKLTHHLAAAPLCTPSRAAFLTGRYPIRSGMASShgmrviLFT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 109 TSVGGLPLNETTLAEVLQQAGYVTGMIGKWHLGHH------GPYHPNFRGFDYYFGIPYSHDMGCTDTPG----YNHPP- 177
Cdd:cd16159 81 ASSGGLPPNETTFAEVLKQQGYSTALIGKWHLGLHcesrndFCHHPLNHGFDYFYGLPLTNLKDCGDGSNgeydLSFDPl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 178 -------CPAC-----------PRGDRPSRSLERDCYTDVALP-------------LYENLNIVEQPVNLSSLAHKYAEK 226
Cdd:cd16159 161 fplltafVLITaltiflllylgAVSKRFFVFLLILSLLFISLFflllitnryfnciLMRNHEVVEQPMSLENLTQRLTKE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 227 AIQFIQhaSASGRPFLLYMGLAHMHVPISRTQLsavLRGRR---PYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGD 302
Cdd:cd16159 241 AISFLE--RNKERPFLLVMSFLHVHTALFTSKK---FKGRSkhgRYGDNVEEMDWSVGQILDALDELGlKDNTFVYFTSD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 303 NGPWAqkcELAGSVGPFTGLWQTHQGGSpaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQ 382
Cdd:cd16159 316 NGGHL---EEISVGGEYGGGNGGIYGGK--KMGGWEGGIRVPTIVRWPGVIPPGSVIDEPTSLMDIFPTVAALAGAPLPS 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 383 DRHFDGLDASEVLFGWSQ-TGHRVLFH------------PNSGAAgefgalqtvrlgSYKAFYVS----GGAKACDG--- 442
Cdd:cd16159 391 DRIIDGRDLMPLLTGQEKrSPHEFLFHycgaelhavryrPRDGGA------------VWKAHYFTpnfyPGTEGCCGtll 458
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 115503411 443 ---DVGREQHHDPPLIFNLEDDVAEAVPLDRGSAEYQGVLPKVREILAD 488
Cdd:cd16159 459 crcFGDSVTHHDPPLLFDLSADPSESNPLDPTDEPYQEIIKKILEAVAE 507
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
36-461 |
2.69e-92 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 286.74 E-value: 2.69e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGAN---WAETKDTANLDKMAAEGMRFVDFHAAAStCSPSRASLLTGRLGLRNGVTHNFAVTSVG 112
Cdd:cd16142 1 PNILVILGDDIGWGDLGCYgggIGRGAPTPNIDRLAKEGLRFTSFYVEPS-CTPGRAAFITGRHPIRTGLTTVGLPGSPG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 113 GLPLNETTLAEVLQQAGYVTGMIGKWHLGHHgPYH-PNFRGFDYYFGIPYSHDmgctdtpgynhppcpacprgdrpsrsl 191
Cdd:cd16142 80 GLPPWEPTLAELLKDAGYATAQFGKWHLGDE-DGRlPTDHGFDEFYGNLYHTI--------------------------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 192 erDCYtdvalplyenlniveqpvnlsslahkYAEKAIQFIQHASASGRPFLLYMGLAHMHVPIS-RTQLSAVLRGRRPYG 270
Cdd:cd16142 132 --DEE--------------------------IVDKAIDFIKRNAKADKPFFLYVNFTKMHFPTLpSPEFEGKSSGKGKYA 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 271 AGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGPWAQKCELAGSvGPFTGlwqthqggspAKQTTWEGGHRVPALAYW 349
Cdd:cd16142 184 DSMVELDDHVGQILDALDELGiADNTIVIFTTDNGPEQDVWPDGGY-TPFRG----------EKGTTWEGGVRVPAIVRW 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 350 PGRVPVNVTSTALLSVLDIFPTVVALAGASLP------QDRHFDGLDASEVLFGWS-QTGHRVLFHpnsGAAGEFGAlqt 422
Cdd:cd16142 253 PGKIKPGRVSNEIVSHLDWFPTLAALAGAPDPkdkllgKDRHIDGVDQSPFLLGKSeKSRRSEFFY---FGEGELGA--- 326
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 115503411 423 VRLGSYKA-FYVSGGAKAcdGDVGREQHHDPPLIFNLEDD 461
Cdd:cd16142 327 VRWKNWKVhFKAQEDTGG--PTGEPFYVLTFPLIFNLRRD 364
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
34-497 |
1.74e-87 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 274.83 E-value: 1.74e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvTSVGG 113
Cdd:COG3119 22 KRPNILFILADDLGYGDLGCYGNPLIKTPNIDRLAAEGVRFTNAYVTSPVCSPSRASLLTGRYPHRTGVTDNGE-GYNGG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLghhgpyhpnfrgfdyyfgipyshdmgctdtpgynhppcpacprgdrpsrsler 193
Cdd:COG3119 101 LPPDEPTLAELLKEAGYRTALFGKWHL----------------------------------------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcYTDvalplyenlniveqpvnlsslaHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPI------------------- 254
Cdd:COG3119 128 --YLT----------------------DLLTDKAIDFLERQADKDKPFFLYLAFNAPHAPYqapeeyldkydgkdiplpp 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 255 ----SRTQLSAVLRGRRPYGAGLREMDSLVGQIKDKVDRT-AKENTFLWFTGDNGPWAQKcelagsvgpftglwQTHQGG 329
Cdd:COG3119 184 nlapRDLTEEELRRARAAYAAMIEEVDDQVGRLLDALEELgLADNTIVVFTSDNGPSLGE--------------HGLRGG 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 330 spaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDrhFDGLDASEVLFGWSQTGHRVLFHp 409
Cdd:COG3119 250 ---KGTLYEGGIRVPLIVRWPGKIKAGSVSDALVSLIDLLPTLLDLAGVPIPED--LDGRSLLPLLTGEKAEWRDYLYW- 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 410 nsgAAGEFGALQTVRLGSYKAFYvsggakacdgdvgREQHHDPPLIFNLEDDVAEAVPLdrgSAEYqgvlPKVREILADV 489
Cdd:COG3119 324 ---EYPRGGGNRAIRTGRWKLIR-------------YYDDDGPWELYDLKNDPGETNNL---AADY----PEVVAELRAL 380
|
....*...
gi 115503411 490 LLDIAGDN 497
Cdd:COG3119 381 LEAWLKEL 388
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
36-465 |
4.47e-87 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 274.81 E-value: 4.47e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNF--------- 106
Cdd:cd16144 1 PNIVLILVDDLGWADLGCYGSKFYETPNIDRLAKEGMRFTQAYAAAPVCSPSRASILTGQYPARLGITDVIpgrrgppdn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 107 ----AVTSVGGLPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGI-PYSHDMGCTDTPGYNHPPCPAC 181
Cdd:cd16144 81 tkliPPPSTTRLPLEEVTIAEALKDAGYATAHFGKWHLGGEGGYGPEDQGFDVNIGGtGNGGPPSYYFPPGKPNPDLEDG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 182 PRGDRPSRSLerdcytdvalplyenlniveqpvnlsslahkyAEKAIQFIQhaSASGRPFLLYmgLAH--MHVPI-SRTQ 258
Cdd:cd16144 161 PEGEYLTDRL--------------------------------TDEAIDFIE--QNKDKPFFLY--LSHyaVHTPIqARPE 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 259 LSAVLRGRRP----------YGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGPWAQKCELAGSVGPFTGlwqthq 327
Cdd:cd16144 205 LIEKYEKKKKglrkgqknpvYAAMIESLDESVGRILDALEELGlADNTLVIFTSDNGGLSTRGGPPTSNAPLRG------ 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 328 ggspAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHR--V 405
Cdd:cd16144 279 ----GKGSLYEGGIRVPLIVRWPGVIKPGSVSDVPVIGTDLYPTFLELAGGPLPPPQHLDGVSLVPLLKGGEADLPRraL 354
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115503411 406 LFH-PN-SGAAGEFGAlqTVRLGSYK--AFYVSGGAKacdgdvgreqhhdpplIFNLEDDVAEA 465
Cdd:cd16144 355 FWHfPHyHGQGGRPAS--AIRKGDWKliEFYEDGRVE----------------LYNLKNDIGET 400
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
36-464 |
1.65e-82 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 262.14 E-value: 1.65e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETK-DTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNfaVTSVGGL 114
Cdd:cd16143 1 PNIVIILADDLGYGDISCYNPDSKiPTPNIDRLAAEGMRFTDAHSPSSVCTPSRYGLLTGRYPWRSRLKGG--VLGGFSP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 PL---NETTLAEVLQQAGYVTGMIGKWHLG---------HHGPYH-------------PNFRGFDYYFGIPYShdmgctd 169
Cdd:cd16143 79 PLiepDRVTLAKMLKQAGYRTAMVGKWHLGldwkkkdgkKAATGTgkdvdyskpikggPLDHGFDYYFGIPAS------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 170 tpgynhppcpacprgdrpsrslerdcytDVaLPLyenlniveqpvnlsslahkYAEKAIQFIQHASASGRPFLLYMGLAH 249
Cdd:cd16143 152 ----------------------------EV-LPT-------------------LTDKAVEFIDQHAKKDKPFFLYFALPA 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 250 MHVPIS-------RTQLSavlrgrrPYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGP----WAQKCELAG--S 315
Cdd:cd16143 184 PHTPIVpspefqgKSGAG-------PYGDFVYELDWVVGRILDALKELGlAENTLVIFTSDNGPspyaDYKELEKFGhdP 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 316 VGPFTGLwqthqggspaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVL 395
Cdd:cd16143 257 SGPLRGM----------KADIYEGGHRVPFIVRWPGKIPAGSVSDQLVSLTDLFATLAAIVGQKLPDNAAEDSFSFLPAL 326
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115503411 396 FGWSQTGHRV-LFHpnSGAAGEFgalqTVRLGSYKaFYVSGGAKACDGDVGREQHHDPP-LIFNLEDDVAE 464
Cdd:cd16143 327 LGPKKQEVREsLVH--HSGNGSF----AIRKGDWK-LIDGTGSGGFSYPRGKEKLGLPPgQLYNLSTDPGE 390
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
36-464 |
7.12e-77 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 247.85 E-value: 7.12e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAaSTCSPSRASLLTGRLGLRNGVTHnfavTSVGG-- 113
Cdd:cd16146 1 PNVILILTDDQGYGDLGFHGNPILKTPNLDRLAAESVRFTNFHVS-PVCAPTRAALLTGRYPFRTGVWH----TILGRer 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHDmgcTDTPGY--NHPPCPACPRGDRPSRSl 191
Cdd:cd16146 76 MRLDETTLAEVFKDAGYRTGIFGKWHLGDNYPYRPQDRGFDEVLGHGGGGI---GQYPDYwgNDYFDDTYYHNGKFVKT- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 192 ERDCyTDValplyenlniveqpvnlsslahkYAEKAIQFIQhaSASGRPFLLYMGLAHMHVPIS-RTQLSAvlrgrRPYG 270
Cdd:cd16146 152 EGYC-TDV-----------------------FFDEAIDFIE--ENKDKPFFAYLATNAPHGPLQvPDKYLD-----PYKD 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 271 AGLRE-----------MDSLVGQIKDKVDRT-AKENTFLWFTGDNGPWaqkcelagsvGPFTGLWQTHQGGSpaKQTTWE 338
Cdd:cd16146 201 MGLDDklaafygmienIDDNVGRLLAKLKELgLEENTIVIFMSDNGPA----------GGVPKRFNAGMRGK--KGSVYE 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 339 GGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQ-TGHRVLF-HPNSGAAGE 416
Cdd:cd16146 269 GGHRVPFFIRWPGKILAGKDVDTLTAHIDLLPTLLDLCGVKLPEGIKLDGRSLLPLLKGESDpWPERTLFtHSGRWPPPP 348
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 115503411 417 FG-ALQTVRLGSYKafYVSGgakacdgdvgreqHHDPPLIFNLEDDVAE 464
Cdd:cd16146 349 KKkRNAAVRTGRWR--LVSP-------------KGFQPELYDIENDPGE 382
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
36-464 |
1.86e-75 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 244.43 E-value: 1.86e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGGLP 115
Cdd:cd16145 1 PNIIFILADDLGYGDLGCYGQKKIKTPNLDRLAAEGMRFTQHYAGAPVCAPSRASLLTGLHTGHTRVRGNSEPGGQDPLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHLG-HHGPYHPNFRGFDYYFGIpYSHdmgctdTPGYNH-PPcpacprgdrpsrSLER 193
Cdd:cd16145 81 PDDVTLAEVLKKAGYATAAFGKWGLGgPGTPGHPTKQGFDYFYGY-LDQ------VHAHNYyPE------------YLWR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 DcytDVALPLYENLNIVEQPVNLSSLAHK-YAE-----KAIQFIQ-HASasgRPFLLYMGL----AHMHVP--------- 253
Cdd:cd16145 142 N---GEKVPLPNNVIPPLDEGNNAGGGGGtYSHdlftdEALDFIReNKD---KPFFLYLAYtlphAPLQVPddgpykykp 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 254 --ISRTQLSAVLRGRRPYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGP-----WAQKCELAGSVGPFTGLwqt 325
Cdd:cd16145 216 kdPGIYAYLPWPQPEKAYAAMVTRLDRDVGRILALLKELGiDENTLVVFTSDNGPhseggSEHDPDFFDSNGPLRGY--- 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 326 hqggspaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDrhFDGLDASEVLFGWS-QTGHR 404
Cdd:cd16145 293 -------KRSLYEGGIRVPFIARWPGKIPAGSVSDHPSAFWDFMPTLADLAGAEPPED--IDGISLLPTLLGKPqQQQHD 363
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 405 VLFHpnsgAAGEFGALQTVRLGSYKAFYVSGGAkacdgdvgreqhhDPPLIFNLEDDVAE 464
Cdd:cd16145 364 YLYW----EFYEGGGAQAVRMGGWKAVRHGKKD-------------GPFELYDLSTDPGE 406
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
36-390 |
6.24e-69 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 221.54 E-value: 6.24e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNfaVTSVGGLP 115
Cdd:cd16022 1 PNILLIMTDDLGYDDLGCYGNPDIKTPNLDRLAAEGVRFTNAYVASPVCSPSRASLLTGRYPHRHGVRGN--VGNGGGLP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHlghhgpyhpnfrgfdyyfgipyshdmgctdtpgynhppcpacprgdrpsrslerdc 195
Cdd:cd16022 79 PDEPTLAELLKEAGYRTALIGKWH-------------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 196 ytdvalplyenlniveqpvnlsslahkyaEKAIQFIQHASASgRPFLLYMGLAHMHVPISrtqlsavlrgrrpYGAGLRE 275
Cdd:cd16022 103 -----------------------------DEAIDFIERRDKD-KPFFLYVSFNAPHPPFA-------------YYAMVSA 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 276 MDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcelaGSVGPFTGLWQthqggspaKQTTWEGGHRVPALAYWPGRVP 354
Cdd:cd16022 140 IDDQIGRILDALEELGLlDNTLIVFTSDHG---------DMLGDHGLRGK--------KGSLYEGGIRVPFIVRWPGKIP 202
|
330 340 350
....*....|....*....|....*....|....*.
gi 115503411 355 VNVTSTALLSVLDIFPTVVALAGASLPqdRHFDGLD 390
Cdd:cd16022 203 AGQVSDALVSLLDLLPTLLDLAGIEPP--EGLDGRS 236
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
36-390 |
3.53e-64 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 214.34 E-value: 3.53e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFvDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSV-GGL 114
Cdd:cd16029 1 PHIVFILADDLGWNDVGFHGSDQIKTPNLDALAADGVIL-NNYYVQPICTPSRAALMTGRYPIHTGMQHGVILAGEpYGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 PLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYH-PNFRGFDYYFGiPYShdmGCTDtpGYNHPPCPACPRGDRPSRSLE- 192
Cdd:cd16029 80 PLNETLLPQYLKELGYATHLVGKWHLGFYTWEYtPTNRGFDSFYG-YYG---GAED--YYTHTSGGANDYGNDDLRDNEe 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 193 -----RDCYTdvalplyenlniveqpvnlsslAHKYAEKAIQFIQHASASgRPFLLYMGLAHMHVPISRTQLSAVL---- 263
Cdd:cd16029 154 pawdyNGTYS----------------------TDLFTDRAVDIIENHDPS-KPLFLYLAFQAVHAPLQVPPEYADPyedk 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 264 ------RGRRPYGAGLREMDSLVGQIKDK-VDRTAKENTFLWFTGDNGPWAQKCElAGSVGPFTGlwqthqggspAKQTT 336
Cdd:cd16029 211 fahikdEDRRTYAAMVSALDESVGNVVDAlKAKGMLDNTLIVFTSDNGGPTGGGD-GGSNYPLRG----------GKNTL 279
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 115503411 337 WEGGHRVPALAYWPGRVPV-NVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLD 390
Cdd:cd16029 280 WEGGVRVPAFVWSPLLPPKrGTVSDGLMHVTDWLPTLLSLAGGDPDDLPPLDGVD 334
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
36-429 |
2.67e-61 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 206.30 E-value: 2.67e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAAStCSPSRASLLTGRLGLRNGVTHnfavtsvGGLP 115
Cdd:cd16151 1 PNIILIMADDLGYECIGCYGGESYKTPNIDALAAEGVRFNNAYAQPL-CTPSRVQLMTGKYNFRNYVVF-------GYLD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHLG---HHGPYHPNFrGFDYYFGIPYSHdmgcTDTPGYNHPPcpacprgdrpsrsLE 192
Cdd:cd16151 73 PKQKTFGHLLKDAGYATAIAGKWQLGggrGDGDYPHEF-GFDEYCLWQLTE----TGEKYSRPAT-------------PT 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 193 RDCYTDVALPLYENlniveqpvnlsslahKY-----AEKAIQFIQHASAsgRPFLLY--MGLAH---MHVPISR-TQLSA 261
Cdd:cd16151 135 FNIRNGKLLETTEG---------------DYgpdlfADFLIDFIERNKD--QPFFAYypMVLVHdpfVPTPDSPdWDPDD 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 262 VLRGRRP--YGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNgpwaqkcelaGSVGPFTGLW--QTHQGGspaKQTT 336
Cdd:cd16151 198 KRKKDDPeyFPDMVAYMDKLVGKLVDKLEELGlRENTIIIFTGDN----------GTHRPITSRTngREVRGG---KGKT 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 337 WEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSGAAGE 416
Cdd:cd16151 265 TDAGTHVPLIVNWPGLIPAGGVSDDLVDFSDFLPTLAELAGAPLPEDYPLDGRSFAPQLLGKTGSPRREWIYWYYRNPHK 344
|
410
....*....|...
gi 115503411 417 FGALQTVRLGSYK 429
Cdd:cd16151 345 KFGSRFVRTKRYK 357
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
36-378 |
2.05e-56 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 190.71 E-value: 2.05e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNfavtSVGGLP 115
Cdd:pfam00884 1 PNVVLVLGESLRAPDLGLYGYPRPTTPFLDRLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVS----TPVGLP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFG-IPYSHDMGCTDTPGYNHPPcpacprgdrpsrsleRD 194
Cdd:pfam00884 77 RTEPSLPDLLKRAGYNTGAIGKWHLGWYNNQSPCNLGFDKFFGrNTGSDLYADPPDVPYNCSG---------------GG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 195 CYTDValplyenlniveqpvnlsslahkYAEKAIQFIQHASasgRPFLLYMGLAHMHVP------------ISRTQLSAV 262
Cdd:pfam00884 142 VSDEA-----------------------LLDEALEFLDNND---KPFFLVLHTLGSHGPpyypdrypekyaTFKPSSCSE 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 263 LRGRRPYGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGPwaqkcelagSVGPFTGLWQTHQGGspakqTTWEGGH 341
Cdd:pfam00884 196 EQLLNSYDNTLLYTDDAIGRVLDKLEENGLlDNTLVVYTSDHGE---------SLGEGGGYLHGGKYD-----NAPEGGY 261
|
330 340 350
....*....|....*....|....*....|....*..
gi 115503411 342 RVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGA 378
Cdd:pfam00884 262 RVPLLIWSPGGKAKGQKSEALVSHVDLFPTILDLAGI 298
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
34-468 |
1.08e-54 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 189.19 E-value: 1.08e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 34 QKPNFVIILADDMGWGDLGANWAETkDTANLDKMAAEGMRFVDFHAAAsTCSPSRASLLTGRLGLRNGV-THNFAVTSVG 112
Cdd:cd16025 1 GRPNILLILADDLGFSDLGCFGGEI-PTPNLDALAAEGLRFTNFHTTA-LCSPTRAALLTGRNHHQVGMgTMAELATGKP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 113 G----LPLNETTLAEVLQQAGYVTGMIGKWHLGHHgpyhpnfrgfDYYFgipySHDmgctdtpgynhppcpacprgdrps 188
Cdd:cd16025 79 GyegyLPDSAATIAEVLKDAGYHTYMSGKWHLGPD----------DYYS----TDD------------------------ 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 189 rslerdcytdvalplyenlniveqpvnlsslahkYAEKAIQFIQHASASGRPFLLYM--GLAH--MHVP---ISR----- 256
Cdd:cd16025 121 ----------------------------------LTDKAIEYIDEQKAPDKPFFLYLafGAPHapLQAPkewIDKykgky 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 257 ------------------------TQLSAVLRGRRP------------------YGAGLREMDSLVGQIKDKVDRTAK-E 293
Cdd:cd16025 167 dagwdalreerlerqkelglipadTKLTPRPPGVPAwdslspeekklearrmevYAAMVEHMDQQIGRLIDYLKELGElD 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 294 NTFLWFTGDNGP-----WAQkcelAGSvGPFTGlwqthqggspAKQTTWEGGHRVPALAYWPGRV-PVNVTSTALLSVLD 367
Cdd:cd16025 247 NTLIIFLSDNGAsaepgWAN----ASN-TPFRL----------YKQASHEGGIRTPLIVSWPKGIkAKGGIRHQFAHVID 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 368 IFPTVVALAGASLPQDRH------FDGLDASEVLFG-WSQTGHRVLFHPNSGAAGefgalqtVRLGSYKAFYVSGGAkac 440
Cdd:cd16025 312 IAPTILELAGVEYPKTVNgvpqlpLDGVSLLPTLDGaAAPSRRRTQYFELFGNRA-------IRKGGWKAVALHPPP--- 381
|
490 500
....*....|....*....|....*...
gi 115503411 441 dGDVGREQhhdpplIFNLEDDVAEAVPL 468
Cdd:cd16025 382 -GWGDQWE------LYDLAKDPSETHDL 402
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
35-461 |
2.04e-50 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 177.76 E-value: 2.04e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVtsvggL 114
Cdd:cd16034 1 KPNILFIFADQHRAQALGCAGDDPVKTPNLDRLAKEGVVFTNAVSNYPVCSPYRASLLTGQYPLTNGVFGNDVP-----L 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 PLNETTLAEVLQQAGYVTGMIGKWHL-GHHGPYH--------PNFR-GFDYYFGipyshdMGCTDtpGYNHPpcpacPRG 184
Cdd:cd16034 76 PPDAPTIADVLKDAGYRTGYIGKWHLdGPERNDGraddytppPERRhGFDYWKG------YECNH--DHNNP-----HYY 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 185 DRPSRSLERDCYTDVALplyenlniveqpvnlsslahkyAEKAIQFIQHASASGRPFLLY--MGLAH------------M 250
Cdd:cd16034 143 DDDGKRIYIKGYSPDAE----------------------TDLAIEYLENQADKDKPFALVlsWNPPHdpyttapeeyldM 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 251 H----------VPISRTQLSAVLRGRRPYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGpwaqkcELAGSvgpf 319
Cdd:cd16034 201 YdpkklllrpnVPEDKKEEAGLREDLRGYYAMITALDDNIGRLLDALKELGlLENTIVVFTSDHG------DMLGS---- 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 320 tglwqtHqgGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGasLPQDRHFDGLDASEVLFGWS 399
Cdd:cd16034 271 ------H--GLMNKQVPYEESIRVPFIIRYPGKIKAGRVVDLLINTVDIMPTLLGLCG--LPIPDTVEGRDLSPLLLGGK 340
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115503411 400 QTGHR----VLFHPNSG-AAGEFGALQTVRLGSYKafYVsggakaCDGDvgreqhhDPPLIFNLEDD 461
Cdd:cd16034 341 DDEPDsvllQCFVPFGGgSARDGGEWRGVRTDRYT--YV------RDKN-------GPWLLFDNEKD 392
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
36-407 |
6.23e-50 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 175.77 E-value: 6.23e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGA--NWAETkdtANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFavTSVGG 113
Cdd:cd16027 1 PNILWIIADDLSPDLGGYggNVVKT---PNLDRLAAEGVRFTNAFTTAPVCSPSRSALLTGLYPHQNGAHGLR--SRGFP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWhlghHGPYHPNFRGFDYYFGIPYSHDMgctdtpgynhppcpacprgdrpsrsler 193
Cdd:cd16027 76 LPDGVKTLPELLREAGYYTGLIGKT----HYNPDAVFPFDDEMRGPDDGGRN---------------------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalplyenlniveqpvnlsslAHKYAEKAIQFIQHAsASGRPFLLYMGLAHMHVPisRTQLSAVLRGRRP----- 268
Cdd:cd16027 124 --------------------------AWDYASNAADFLNRA-KKGQPFFLWFGFHDPHRP--YPPGDGEEPGYDPekvkv 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 269 ----------------YGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcelagsvGPFTGlwqthqggsp 331
Cdd:cd16027 175 ppylpdtpevredladYYDEIERLDQQVGEILDELEEDGLlDNTIVIFTSDHG------------MPFPR---------- 232
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115503411 332 AKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQdrHFDGLDASEVLFGWSQTGHRVLF 407
Cdd:cd16027 233 AKGTLYDSGLRVPLIVRWPGKIKPGSVSDALVSFIDLAPTLLDLAGIEPPE--YLQGRSFLPLLKGEKDPGRDYVF 306
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
34-407 |
1.01e-42 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 157.69 E-value: 1.01e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvtsvGG 113
Cdd:cd16031 1 KRPNIIFILTDDHRYDALGCYGNPIVKTPNIDRLAKEGVRFDNAFVTTSICAPSRASILTGQYSHRHGVTDNNG----PL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGpYHPNfRGFDYYFGIPyshdmGctdtPGYNHPPCPACPRGDRPSRSLER 193
Cdd:cd16031 77 FDASQPTYPKLLRKAGYQTAFIGKWHLGSGG-DLPP-PGFDYWVSFP-----G----QGSYYDPEFIENGKRVGQKGYVT 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 DCYTDVALPLYENlNIVEQPVNLsSLAHK---------------YAEKAIQFIQHAS---ASGRPFLLYMGLAHMHVPIS 255
Cdd:cd16031 146 DIITDKALDFLKE-RDKDKPFCL-SLSFKaphrpftpaprhrglYEDVTIPEPETFDdddYAGRPEWAREQRNRIRGVLD 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 256 RTQLS--AVLRGRRPYGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcelagsvgpFT----GLwqthqG 328
Cdd:cd16031 224 GRFDTpeKYQRYMKDYLRTVTGVDDNVGRILDYLEEQGLaDNTIIIYTSDNG--------------FFlgehGL-----F 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115503411 329 GspaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPqdRHFDGLDASEVLFGWSQTGHRVLF 407
Cdd:cd16031 285 D---KRLMYEESIRVPLIIRDPRLIKAGTVVDALVLNIDFAPTILDLAGVPIP--EDMQGRSLLPLLEGEKPVDWRKEF 358
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
36-384 |
4.19e-42 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 151.24 E-value: 4.19e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGV-----THNFAVTS 110
Cdd:cd16149 1 PNILFILTDDQGPWALGCYGNSEAVTPNLDRLAAEGVRFENFFCTSPVCSPARASLLTGRMPSQHGIhdwivEGSHGKTK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 111 VG-GLPLNETTLAEVLQQAGYVTGMIGKWHLGhhgpyhpnfrgfdyyfgipyshdmgctdtpgynhppcpacprgdrpsr 189
Cdd:cd16149 81 KPeGYLEGQTTLPEVLQDAGYRCGLSGKWHLG------------------------------------------------ 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 190 slerdcytdvalplyenlniveqpvnlsslahkyaEKAIQFIQHASASGRPFLLYMGLAHMHVPISrtqlsavlrgrrpY 269
Cdd:cd16149 113 -----------------------------------DDAADFLRRRAEAEKPFFLSVNYTAPHSPWG-------------Y 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 270 GAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGpwaqkcelagsvgpFT----GLWQTHQGGSPakQTTWEGGHRVP 344
Cdd:cd16149 145 FAAVTGVDRNVGRLLDELEELGlTENTLVIFTSDNG--------------FNmghhGIWGKGNGTFP--LNMYDNSVKVP 208
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 115503411 345 ALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDR 384
Cdd:cd16149 209 FIIRWPGVVPAGRVVDSLVSAYDFFPTLLELAGVDPPADP 248
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
36-404 |
7.87e-40 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 148.27 E-value: 7.87e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWgDLGANWAETKD---TANLDKMAAEGMRFVDFHAAaSTCSPSRASLLTGRLGLRNGVThnfavtSVG 112
Cdd:cd16154 1 PNILLIIADDQGL-DSSAQYSLSSDlpvTPTLDSLANSGIVFDNLWAT-PACSPTRATILTGKYGFRTGVL------AVP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 113 G-LPLNETTL--AEVLQQ--AGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIpyshdmgctdTPGynhppcpacprgdrp 187
Cdd:cd16154 73 DeLLLSEETLlqLLIKDAttAGYSSAVIGKWHLGGNDNSPNNPGGIPYYAGI----------LGG--------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 188 srslerdcytdvALPLYENLNIVEQPVNLSSlaHKYA-----EKAIQFIQHASasgRPFLLYMGLAHMHVPI-------- 254
Cdd:cd16154 128 ------------GVQDYYNWNLTNNGQTTNS--TEYAttkltNLAIDWIDQQT---KPWFLWLAYNAPHTPFhlppaelh 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 255 SRT---QLSAVLRGRRP-YGAGLREMDSLVGQIKDKVDRTAKENTFLWFTGDNG-PwaqkcelagsvGPFTGLWQTHQGg 329
Cdd:cd16154 191 SRSllgDSADIEANPRPyYLAAIEAMDTEIGRLLASIDEEERENTIIIFIGDNGtP-----------GQVVDLPYTRNH- 258
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115503411 330 spAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQdrHFDGLDASEVLFGWSQTGHR 404
Cdd:cd16154 259 --AKGSLYEGGINVPLIVSGAGVERANERESALVNATDLYATIAELAGVDAAE--IHDSVSFKPLLSDVNASTRQ 329
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
35-388 |
1.77e-36 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 139.61 E-value: 1.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWgDLGANWAETKdTANLdkMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvtSVGGL 114
Cdd:cd16147 1 RPNIVLILTDDQDV-ELGSMDPMPK-TKKL--LADQGTTFTNAFVTTPLCCPSRASILTGQYAHNHGVTNNSP--PGGGY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 P------LNETTLAEVLQQAGYVTGMIGK----WHLGHHGPYHPnfRGFDYYFGIPyshdmgcTDTPGYNHppCPACPRG 184
Cdd:cd16147 75 PkfwqngLERSTLPVWLQEAGYRTAYAGKylngYGVPGGVSYVP--PGWDEWDGLV-------GNSTYYNY--TLSNGGN 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 185 DRPSRSLERDCYTDValplyenlniveqpvnlsslahkYAEKAIQFIQHASASGRPFLLYMGLAHMHVPI------SRTQ 258
Cdd:cd16147 144 GKHGVSYPGDYLTDV-----------------------IANKALDFLRRAAADDKPFFLVVAPPAPHGPFtpapryANLF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 259 LSAVLRGRRPYG--------AGLREM-------------------------DSLVGQIKDKVDRTAK-ENTFLWFTGDNG 304
Cdd:cd16147 201 PNVTAPPRPPPNnpdvsdkpHWLRRLpplnptqiayidelyrkrlrtlqsvDDLVERLVNTLEATGQlDNTYIIYTSDNG 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 305 pwaqkcelagsvgpftglwqTHQGG---SPAKQTTWEGGHRVPALAYWPGrVPVNVTSTALLSVLDIFPTVVALAGASLP 381
Cdd:cd16147 281 --------------------YHLGQhrlPPGKRTPYEEDIRVPLLVRGPG-IPAGVTVDQLVSNIDLAPTILDLAGAPPP 339
|
....*..
gi 115503411 382 qdRHFDG 388
Cdd:cd16147 340 --SDMDG 344
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
34-488 |
2.55e-34 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 133.07 E-value: 2.55e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAAST----CSPSRASLLTGRlglrngvtHNFAVT 109
Cdd:cd16155 1 KKPNILFILADDQRADTIGALGNPEIQTPNLDRLARRGTSFTNAYNMGGWsgavCVPSRAMLMTGR--------TLFHAP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 110 SVGG--LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPyhpnfrgfdyyfGIPYSHDMGCTDTP-----GYNHppcPACP 182
Cdd:cd16155 73 EGGKaaIPSDDKTWPETFKKAGYRTFATGKWHNGFADA------------AIEFLEEYKDGDKPffmyvAFTA---PHDP 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 183 RgDRPSRSLERdcYTDVALPLYENLnIVEQPVnlsslahkyaekaiqfiQHASASGRPFLLymglahmhVPISRTQlSAV 262
Cdd:cd16155 138 R-QAPPEYLDM--YPPETIPLPENF-LPQHPF-----------------DNGEGTVRDEQL--------APFPRTP-EAV 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 263 LRGRRPYGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkceLA-GSvgpfTGLwqthQGgspaKQTTWEGG 340
Cdd:cd16155 188 RQHLAEYYAMITHLDAQIGRILDALEASGElDNTIIVFTSDHG-------LAvGS----HGL----MG----KQNLYEHS 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 341 HRVPALAYWPGrVPVNVTSTALLSVLDIFPTVVALAGASLPQdrHFDGLDASEVLFGWSQTGHRVLFhpnsgaaGEFGAL 420
Cdd:cd16155 249 MRVPLIISGPG-IPKGKRRDALVYLQDVFPTLCELAGIEIPE--SVEGKSLLPVIRGEKKAVRDTLY-------GAYRDG 318
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115503411 421 Q-TVRLGSYKAFYVSGGAKacdgdvgREQhhdpplIFNLEDDVAEAVPLDrGSAEYQgvlPKVREILAD 488
Cdd:cd16155 319 QrAIRDDRWKLIIYVPGVK-------RTQ------LFDLKKDPDELNNLA-DEPEYQ---ERLKKLLAE 370
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
36-388 |
4.95e-34 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 133.12 E-value: 4.95e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNF--AVTSVGG 113
Cdd:cd16033 1 PNILFIMTDQQRYDTLGCYGNPIVKTPNIDRLAAEGVRFTNAYTPSPVCCPARASLLTGLYPHEHGVLNNVenAGAYSRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHgpYHPNFRGFDYYFgipyshdmgctdtpgynhppcpacprgdrpsrsler 193
Cdd:cd16033 81 LPPGVETFSEDLREAGYRNGYVGKWHVGPE--ETPLDYGFDEYL------------------------------------ 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalplyenlniveqPVNlSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVP-------------------- 253
Cdd:cd16033 123 -------------------PVE-TTIEYFLADRAIEMLEELAADDKPFFLRVNFWGPHDPyippepyldmydpediplpe 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 254 -----------ISR------TQLSAVLRGRRP----YGAGLREMDSLVGQIKDKVDRT-AKENTFLWFTGDNGpwaqkcE 311
Cdd:cd16033 183 sfaddfedkpyIYRrerkrwGVDTEDEEDWKEiiahYWGYITLIDDAIGRILDALEELgLADDTLVIFTSDHG------D 256
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115503411 312 LAGSvgpfTGLWQthQGGSPAKQTtweggHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDrhFDG 388
Cdd:cd16033 257 ALGA----HRLWD--KGPFMYEET-----YRIPLIIKWPGVIAAGQVVDEFVSLLDLAPTILDLAGVDVPPK--VDG 320
|
|
| Sulfatase_C |
pfam14707 |
C-terminal region of aryl-sulfatase; |
402-522 |
2.07e-33 |
|
C-terminal region of aryl-sulfatase;
Pssm-ID: 405407 [Multi-domain] Cd Length: 122 Bit Score: 123.19 E-value: 2.07e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 402 GHRVLFHpNSGAAgefgaLQTVRLGSYKAFYV-----SGGAKACDGDVGREQHHDPPLIFNLEDDVAEAVPLDRGSAEYQ 476
Cdd:pfam14707 2 PHEFLFH-YCGAA-----LHAVRWGPYKAHFFtpsfdPPGAEGCYGSKVPVTHHDPPLLFDLERDPSEKYPLSPDSPEYP 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 115503411 477 GVLPKVREILADVLLDI--AGDNTSRADYTRHPSVTPCCnPHHVACRC 522
Cdd:pfam14707 76 EVLAEIKAAVEEHKATLvpVPNQLSKGNYLWDPWLQPCC-PTFPACTC 122
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
31-490 |
1.50e-31 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 127.48 E-value: 1.50e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 31 TRGQKPNFVIILADDMGwGD-LGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLT-------GRLGLRNGV 102
Cdd:PRK13759 2 VQTKKPNIILIMVDQMR-GDcLGCNGNKAVETPNLDMLASEGYNFENAYSAVPSCTPARAALLTglsqwhhGRVGYGDVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 103 THNFavtsvgglplnETTLAEVLQQAGYVTGMIGKWHlghhgpYHP--NFRGFDYYFgipySHDmGCTDTPGYNHPPCPA 180
Cdd:PRK13759 81 PWNY-----------KNTLPQEFRDAGYYTQCIGKMH------VFPqrNLLGFHNVL----LHD-GYLHSGRNEDKSQFD 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 181 CP-------RGDRPSRSLER-----DCYTDVALP--LYENLNiveqPVNLSslahkyAEKAIQFIQHASaSGRPFLLYMG 246
Cdd:PRK13759 139 FVsdylawlREKAPGKDPDLtdigwDCNSWVARPwdLEERLH----PTNWV------GSESIEFLRRRD-PTKPFFLKMS 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 247 LAHMHVPI--------------------------------------SRTQLS--AVLRGRRPYGAGLREMDSLVGQIKDK 286
Cdd:PRK13759 208 FARPHSPYdppkryfdmykdadipdphigdweyaedqdpeggsidaLRGNLGeeYARRARAAYYGLITHIDHQIGRFLQA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 287 V-DRTAKENTFLWFTGDNGpwaqkcELAGSvgpfTGLWQthqggspaKQTTWEGGHRVPALAYWPG---RVPVNVTSTAL 362
Cdd:PRK13759 288 LkEFGLLDNTIILFVSDHG------DMLGD----HYLFR--------KGYPYEGSAHIPFIIYDPGgllAGNRGTVIDQV 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 363 LSVLDIFPTVVALAGASLPQDrhFDGLDASEVLFGwSQTGHRVLFHpnsgaaGEFG----ALQTVRLGSYKAFYVSGgak 438
Cdd:PRK13759 350 VELRDIMPTLLDLAGGTIPDD--VDGRSLKNLIFG-QYEGWRPYLH------GEHAlgysSDNYLTDGKWKYIWFSQ--- 417
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 115503411 439 acdgdVGREQhhdpplIFNLEDDVAEAVPLdRGSAEYQGVLPKVREILADVL 490
Cdd:PRK13759 418 -----TGEEQ------LFDLKKDPHELHNL-SPSEKYQPRLREMRKKLVDHL 457
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
36-461 |
2.21e-31 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 123.81 E-value: 2.21e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVtsvggLP 115
Cdd:cd16037 1 PNILIIMSDEHNPDAMGCYGHPVVRTPNLDRLAARGTRFENAYTPSPICVPSRASFLTGRYVHETGVWDNADP-----YD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHpnfrGFDYyfgipyshdmgctdtpgynhppcpacprgdrpsrslERDC 195
Cdd:cd16037 76 GDVPSWGHALRAAGYETVLIGKLHFRGEDQRH----GFRY------------------------------------DRDV 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 196 ytdvalplyenlniveqpvnlsslahkyAEKAIQFIQHASASGRPFLLYMGLAHMHVP-ISRTQLSA--VLRGRRPYGAG 272
Cdd:cd16037 116 ----------------------------TEAAVDWLREEAADDKPWFLFVGFVAPHFPlIAPQEFYDlyVRRARAAYYGL 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 273 LREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcELAGSvgpfTGLWQthqggspaKQTTWEGGHRVPALAYWPG 351
Cdd:cd16037 168 VEFLDENIGRVLDALEELGLlDNTLIIYTSDHG------DMLGE----RGLWG--------KSTMYEESVRVPMIISGPG 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 352 RVPVNVTSTALlSVLDIFPTVVALAGAslPQDRHFDGLDASEVLFGWSQTGHRVL--FHPNSGAAGEFgalqTVRLGSYK 429
Cdd:cd16037 230 IPAGKRVKTPV-SLVDLAPTILEAAGA--PPPPDLDGRSLLPLAEGPDDPDRVVFseYHAHGSPSGAF----MLRKGRWK 302
|
410 420 430
....*....|....*....|....*....|..
gi 115503411 430 AFYVSGgakacdgdvgreqhhDPPLIFNLEDD 461
Cdd:cd16037 303 YIYYVG---------------YPPQLFDLEND 319
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
36-461 |
2.90e-30 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 120.76 E-value: 2.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvtsvgGLP 115
Cdd:cd16032 1 PNILLIMADQLTAAALPAYGNTVVKTPNLDRLAARGVVFDNAYCNSPLCAPSRASMMTGRLPSRIGAYDNAA-----EFP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHLGhhGP--YHpnfrGFDYyfgipyshdmgctdtpgynhppcpacprgDRpsrsler 193
Cdd:cd16032 76 ADIPTFAHYLRAAGYRTALSGKMHFV--GPdqLH----GFDY-----------------------------DE------- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytDVALplyenlniveqpvnlsslahkyaeKAIQFI-QHA-SASGRPFLLYMGLAHMHVPISRTQ----LSaVLRGRR 267
Cdd:cd16032 114 ----EVAF------------------------KAVQKLyDLArGEDGRPFFLTVSFTHPHDPYVIPQeywdLY-VRRARR 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 268 PYGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcELAGSvgpfTGLWQthqggspaKQTTWEGGHRVPAL 346
Cdd:cd16032 165 AYYGMVSYVDDKVGQLLDTLERTGLaDDTIVIFTSDHG------DMLGE----RGLWY--------KMSFFEGSARVPLI 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 347 AYWPGR-VPVNVTstALLSVLDIFPTVVALAGASLPQDR-HFDGLDASEVLFGWSQTGHRVLFHPNSGaAGEFGALQTVR 424
Cdd:cd16032 227 ISAPGRfAPRRVA--EPVSLVDLLPTLVDLAGGGTAPHVpPLDGRSLLPLLEGGDSGGEDEVISEYLA-EGAVAPCVMIR 303
|
410 420 430
....*....|....*....|....*....|....*..
gi 115503411 425 LGSYKAFYVsggakacdgdvgreqHHDPPLIFNLEDD 461
Cdd:cd16032 304 RGRWKFIYC---------------PGDPDQLFDLEAD 325
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
36-390 |
3.73e-29 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 116.11 E-value: 3.73e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILAD----DMgwgdLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHnfavtsv 111
Cdd:cd16148 1 MNVILIVIDslraDH----LGCYGYDRVTTPNLDRLAAEGVVFDNHYSGSNPTLPSRFSLFTGLYPFYHGVWG------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 112 GGLPLNETTLAEVLQQAGYVTGMIGKW-HLGHHGPYHpnfRGFDYYFGIPYSHdmgctdtpgynhppcpacprGDRPSRS 190
Cdd:cd16148 70 GPLEPDDPTLAEILRKAGYYTAAVSSNpHLFGGPGFD---RGFDTFEDFRGQE--------------------GDPGEEG 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 191 LERdcytdvalplyenlniveqpvnlsslAHKYAEKAIQFIQHAsASGRPFLLYMglaHM---HVPisrtqlsavlrgrR 267
Cdd:cd16148 127 DER--------------------------AERVTDRALEWLDRN-ADDDPFFLFL---HYfdpHEP-------------Y 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 268 PYGAGLREMDSLVGQIKDKVDRT-AKENTFLWFTGDNGpwaqkcELAGSvgpfTGLWQTHQggspakQTTWEGGHRVPAL 346
Cdd:cd16148 164 LYDAEVRYVDEQIGRLLDKLKELgLLEDTLVIVTSDHG------EEFGE----HGLYWGHG------SNLYDEQLHVPLI 227
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 115503411 347 AYWPGRVPVNVTStALLSVLDIFPTVVALAGASLPQDrhFDGLD 390
Cdd:cd16148 228 IRWPGKEPGKRVD-ALVSHIDIAPTLLDLLGVEPPDY--SDGRS 268
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
34-388 |
1.78e-27 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 114.98 E-value: 1.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 34 QKPNFVIILADDM----GWgdLGANWAETkdtANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVtHNFAVT 109
Cdd:cd16030 1 KKPNVLFIAVDDLrpwlGC--YGGHPAKT---PNIDRLAARGVLFTNAYCQQPVCGPSRASLLTGRRPDTTGV-YDNNSY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 110 SVGGLPlNETTLAEVLQQAGYVTGMIGKwhlghhgPYHPNFRGFDYYfgiPYSHDMGCTDTPGYNHPPCPACPRGDRPSr 189
Cdd:cd16030 75 FRKVAP-DAVTLPQYFKENGYTTAGVGK-------IFHPGIPDGDDD---PASWDEPPNPPGPEKYPPGKLCPGKKGGK- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 190 slerdcyTDVALPLYENLNIVEqpvnlSSLA-HKYAEKAIQFIQHASASGRPFLLYMGLAHMHVP--------------- 253
Cdd:cd16030 143 -------GGGGGPAWEAADVPD-----EAYPdGKVADEAIEQLRKLKDSDKPFFLAVGFYKPHLPfvapkkyfdlyples 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 254 ------ISRTQLSAVLRGR----RPYGAGLRE---------------------------MDSLVGQIKDKVDRTA-KENT 295
Cdd:cd16030 211 iplpnpFDPIDLPEVAWNDlddlPKYGDIPALnpgdpkgplpdeqarelrqayyasvsyVDAQVGRVLDALEELGlADNT 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 296 FLWFTGDNGpWaqkcelagSVGPfTGLWqthqggspAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVAL 375
Cdd:cd16030 291 IVVLWSDHG-W--------HLGE-HGHW--------GKHTLFEEATRVPLIIRAPGVTKPGKVTDALVELVDIYPTLAEL 352
|
410
....*....|...
gi 115503411 376 AGasLPQDRHFDG 388
Cdd:cd16030 353 AG--LPAPPCLEG 363
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
36-384 |
1.77e-26 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 109.60 E-value: 1.77e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDM-GWGDLGANWAETKDTAnLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGGL 114
Cdd:cd16035 1 PNILLILTDQErYPPPWPAGWAALNLPA-RERLAANGLSFENHYTAACMCSPSRSTLYTGLHPQQTGVTDTLGSPMQPLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 PLNETTLAEVLQQAGYVTGMIGKWHLGHHGpyhpnfRGfdyyfgipyshdmgctdtpGYNHPPcpacprgdrpsrslerd 194
Cdd:cd16035 80 SPDVPTLGHMLRAAGYYTAYKGKWHLSGAA------GG-------------------GYKRDP----------------- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 195 cytdvalplyenlniveqpvnlsslahKYAEKAIQFIQHASAS---GRPFLLYMGLAHMH-VPISRTQLSAVLRGRRPYG 270
Cdd:cd16035 118 ---------------------------GIAAQAVEWLRERGAKnadGKPWFLVVSLVNPHdIMFPPDDEERWRRFRNFYY 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 271 AGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGpwaqkcELAGSVGpftGLwqtHQGGSPAKQTTwegghRVPALAYW 349
Cdd:cd16035 171 NLIRDVDRQIGRVLDALDASGlADNTIVVFTSDHG------EMGGAHG---LR---GKGFNAYEEAL-----HVPLIISH 233
|
330 340 350
....*....|....*....|....*....|....*
gi 115503411 350 PGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDR 384
Cdd:cd16035 234 PDLFGTGQTTDALTSHIDLLPTLLGLAGVDAEARA 268
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
35-390 |
1.82e-26 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 109.00 E-value: 1.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWGDLGA-NWAETKD---------TANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTH 104
Cdd:cd16153 1 KPNILWIITDDQRVDSLSCyNNAHTGKsesrlgyveSPNIDALAAEGVLFTNAYCNSPVCVPSRTSMLTGRYPHRTGVYG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 105 NFAVTSVGGLPLneTTLAEVLQQAGYVTGMIGKwhlGHHGPYhpnfrgfdyyfgipyshdmgcTDtpgynhppcpacprg 184
Cdd:cd16153 81 FEAAHPALDHGL--PTFPEVLKKAGYQTASFGK---SHLEAF---------------------QR--------------- 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 185 drpsrslerdcYTDVALPLYEnlniveqpvnlsSLAHKYAEKAiqfiqhasASGRPFLLYMGLAHMHVPIsrtQLSAVLR 264
Cdd:cd16153 120 -----------YLKNANQSYK------------SFWGKIAKGA--------DSDKPFFVRLSFLQPHTPV---LPPKEFR 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 265 GRRPYGAGLREMDSLVGQIKDKVDR----TAKENTFLWFTGDNGpwaqkcelagsvgpftglWQTHQGGSPAKQTTWEGG 340
Cdd:cd16153 166 DRFDYYAFCAYGDAQVGRAVEAFKAyslkQDRDYTIVYVTGDHG------------------WHLGEQGILAKFTFWPQS 227
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 115503411 341 HRVPALAYWPGR--VPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLD 390
Cdd:cd16153 228 HRVPLIVVSSDKlkAPAGKVRHDFVEFVDLAPTLLAAAGVDVDAPDYLDGRD 279
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
36-376 |
1.01e-24 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 102.88 E-value: 1.01e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCS-PSRASLLTGRLGLRNGVTHNFAVT----- 109
Cdd:cd00016 1 KHVVLIVLDGLGADDLGKAGNPAPTTPNLKRLASEGATFNFRSVSPPTSSaPNHAALLTGAYPTLHGYTGNGSADpelps 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 110 SVGGLPLNETTLAEVLQQAGYVTGMIGkwhlghhgpyhpnfrgfdyyfgipyshdmgctdtpgynhppcpacprgdrpsr 189
Cdd:cd00016 81 RAAGKDEDGPTIPELLKQAGYRTGVIG----------------------------------------------------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 190 slerdcytdvalplyenlniveqpvnlsslahkyAEKAIQFIqhasASGRPFLLYMGLAHMHVPisrtqLSAVLRGRRPY 269
Cdd:cd00016 108 ----------------------------------LLKAIDET----SKEKPFVLFLHFDGPDGP-----GHAYGPNTPEY 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 270 GAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcelagsvGPFTGLwqTHQGGSPAKQTTWEGGHRVPALAY 348
Cdd:cd00016 145 YDAVEEIDERIGKVLDALKKAGDaDDTVIIVTADHG------------GIDKGH--GGDPKADGKADKSHTGMRVPFIAY 210
|
330 340
....*....|....*....|....*...
gi 115503411 349 WPGrVPVNVTSTALLSVLDIFPTVVALA 376
Cdd:cd00016 211 GPG-VKKGGVKHELISQYDIAPTLADLL 237
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
35-140 |
1.06e-20 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 93.83 E-value: 1.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNfavtsVGGL 114
Cdd:cd16152 1 KPNVIVFFTDQQRWDTLGCYGQPLDLTPNLDALAEEGVLFENAFTPQPVCGPARACLQTGLYPTETGCFRN-----GIPL 75
|
90 100
....*....|....*....|....*.
gi 115503411 115 PLNETTLAEVLQQAGYVTGMIGKWHL 140
Cdd:cd16152 76 PADEKTLAHYFRDAGYETGYVGKWHL 101
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
36-429 |
1.33e-18 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 88.59 E-value: 1.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNG-VTHNFAVTSvggl 114
Cdd:cd16156 1 KQFIFIMTDTQRWDMVGCYGNKAMKTPNLDRLAAEGVRFDSAYTTQPVCGPARSGLFTGLYPHTNGsWTNCMALGD---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 plNETTLAEVLQQAGYVTGMIGKWHLGhhgpyhpnfrGFDYY-FGIpyshdmgctdtpgynhppcpaCPRGDRPSRSLER 193
Cdd:cd16156 77 --NVKTIGQRLSDNGIHTAYIGKWHLD----------GGDYFgNGI---------------------CPQGWDPDYWYDM 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 DCYTD-----------VALPLYENLNIVEQpvnlSSLAHKYAEKAIQFI-QHASasgRPFLL------------------ 243
Cdd:cd16156 124 RNYLDelteeerrksrRGLTSLEAEGIKEE----FTYGHRCTNRALDFIeKHKD---EDFFLvvsydephhpflcpkpya 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 244 --------------YMGLAH---MHVPISRTQLSAV---LRGRRPYGAGLRE-MDSLVGQIKDKVDRTAkENTFLWFTGD 302
Cdd:cd16156 197 smykdfefpkgenaYDDLENkplHQRLWAGAKPHEDgdkGTIKHPLYFGCNSfVDYEIGRVLDAADEIA-EDAWVIYTSD 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 303 NGpwaqkcELAGSvgpfTGLWqthqGGSPAkqtTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGasLPQ 382
Cdd:cd16156 276 HG------DMLGA----HKLW----AKGPA---VYDEITNIPLIIRGKGGEKAGTVTDTPVSHIDLAPTILDYAG--IPQ 336
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 115503411 383 DRHFDGLDASEVLFGWSQTGHRVLF---------HPNsgaageFGALQTVRL---GSYK 429
Cdd:cd16156 337 PKVLEGESILATIEDPEIPENRGVFvefgryevdHDG------FGGFQPVRCvvdGRYK 389
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
36-488 |
2.04e-17 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 84.62 E-value: 2.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvtsvgGLP 115
Cdd:cd16028 1 RNVLFITADQWRADCLSCLGHPLVKTPNLDRLAAEGVRFRNHYTQAAPCGPSRASLYTGRYLMNHRSVWNGT-----PLD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWH----LGHHGPYHPNFR-------GFDYYF---GIPYSH-------DMGCTDTPGYN 174
Cdd:cd16028 76 ARHLTLALELRKAGYDPALFGYTDtspdPRGLAPLDPRLLsyelampGFDPVDrldEYPAEDsdtafltDRAIEYLDERQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 175 -------------HPP--CPAcprgdrPSRSLerdcYTDVALPLyenlniveqPVNLSSLAhkyAEKAiqfiQHasasgr 239
Cdd:cd16028 156 depwflhlsyirpHPPfvAPA------PYHAL----YDPADVPP---------PIRAESLA---AEAA----QH------ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 240 PFLLYM------GLAHMHVPISRTQLSAVLRGRRPYGAGL-REMDSLVGQIKDKVDRTAKE-NTFLWFTGDNGpwaqkcE 311
Cdd:cd16028 204 PLLAAFleriesLSFSPGAANAADLDDEEVAQMRATYLGLiAEVDDHLGRLFDYLKETGQWdDTLIVFTSDHG------E 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 312 LAGsvgpftglwQTHQGGspaKQTTWEGGHRVPALAYWPGRvPVNVTS----TALLSVLDIFPTVVALAGasLPQDRHFD 387
Cdd:cd16028 278 QLG---------DHWLWG---KDGFFDQAYRVPLIVRDPRR-EADATRgqvvDAFTESVDVMPTILDWLG--GEIPHQCD 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 388 GLD-------------ASEVLFGW-----SQTGHRVLFHPNSGAAGefgaLQTVRLGSYKafYVsggakacdgdvgreqH 449
Cdd:cd16028 343 GRSllpllagaqpsdwRDAVHYEYdfrdvSTRRPQEALGLSPDECS----LAVIRDERWK--YV---------------H 401
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 115503411 450 HD--PPLIFNLEDDVAEAVplDRGS-AEYQGVLPKVREILAD 488
Cdd:cd16028 402 FAalPPLLFDLKNDPGELR--DLAAdPAYAAVVLRYAQKLLS 441
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
36-386 |
2.07e-17 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 84.59 E-value: 2.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGR----LGLRNgvTHNFavtsv 111
Cdd:cd16150 1 PNIVIFVADQLRADSLGHLGNPAAVTPNLDALAAEGVRFSNAYCQNPVCSPSRCSFLTGWyphvNGHRT--LHHL----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 112 ggLPLNETTLAEVLQQAGYVTGMIGKWHlghhgpyhpnfrgfdyyfgipyshdmgctDTPGynhppcpacprgdrpSRSL 191
Cdd:cd16150 74 --LRPDEPNLLKTLKDAGYHVAWAGKND-----------------------------DLPG---------------EFAA 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 192 ERDCYTDVAlplyenlniveqpvnlsslahkYAEKAIQFIQHASAsGRPFLLYMGLAHMHVP----------ISRTQL-- 259
Cdd:cd16150 108 EAYCDSDEA----------------------CVRTAIDWLRNRRP-DKPFCLYLPLIFPHPPygveepwfsmIDREKLpp 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 260 -----------SAVLRGRRPYG------AGLREM-----------DSLVGQIKDKVDRTA-KENTFLWFTGDNGPWAqkc 310
Cdd:cd16150 165 rrppglrakgkPSMLEGIEKQGldrwseERWRELratylgmvsrlDHQFGRLLEALKETGlYDDTAVFFFSDHGDYT--- 241
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115503411 311 elagsvGPFtGLWQTHQGGSPAKQTtwegghRVPALAYWPGRVPVNVTStALLSVLDIFPTVVALAGASLPQDrHF 386
Cdd:cd16150 242 ------GDY-GLVEKWPNTFEDCLT------RVPLIIKPPGGPAGGVSD-ALVELVDIPPTLLDLAGIPLSHT-HF 302
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
36-382 |
6.78e-16 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 79.51 E-value: 6.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGrlgLRNGVTHNFavTSVGGLP 115
Cdd:cd16171 1 PNVVMVMSDSFDGRLTFRPGNQVVDLPYINFMKQHGSVFLNAYTNSPICCPSRAAMWSG---LFTHLTESW--NNYKGLD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGK--WHLGHHGPYHpnfRGFDYYFGIPYshdmgctdTPGYNHPPCPACPRGDRPSRSLER 193
Cdd:cd16171 76 PNYPTWMDRLEKHGYHTQKYGKldYTSGHHSVSN---RVEAWTRDVPF--------LLRQEGRPTVNLVGDRSTVRVMLK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 DCytdvalplyenlniveqpvnlsslahKYAEKAIQFIQHASAS-GRPFLLYMGLAHMH---VPISRTQLSAVLRGRRPY 269
Cdd:cd16171 145 DW--------------------------QNTDKAVHWIRKEAPNlTQPFALYLGLNLPHpypSPSMGENFGSIRNIRAFY 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 270 GAGLREMDSLVGQIKDKVDRTAKEN-TFLWFTGDNGpwaqkcELAGSVGPFTglwqthqggspaKQTTWEGGHRVPALAY 348
Cdd:cd16171 199 YAMCAETDAMLGEIISALKDTGLLDkTYVFFTSDHG------ELAMEHRQFY------------KMSMYEGSSHVPLLIM 260
|
330 340 350
....*....|....*....|....*....|....
gi 115503411 349 WPGrVPVNVTSTALLSVLDIFPTVVALAGASLPQ 382
Cdd:cd16171 261 GPG-IKAGQQVSDVVSLVDIYPTMLDIAGVPQPQ 293
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
27-386 |
1.03e-06 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 51.58 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 27 PSGETRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVthnf 106
Cdd:COG1368 226 PNPFGPAKKPNVVVILLESFSDFFIGALGNGKDVTPFLDSLAKESLYFGNFYSQGGRTSRGEFAVLTGLPPLPGGS---- 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 107 AVTSVGGLPLNetTLAEVLQQAGYVTGMIgkwhlghHGpYHPNFR---------GFDYYFGI-----PYSHDMGCTDTPG 172
Cdd:COG1368 302 PYKRPGQNNFP--SLPSILKKQGYETSFF-------HG-GDGSFWnrdsfyknlGFDEFYDRedfddPFDGGWGVSDEDL 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 173 YNHppcpacprgdrpsrslerdcytdvalpLYENLNIVEQP-----VNLSSlaHkyaekaiqfiqhasasgRPFLLYMGL 247
Cdd:COG1368 372 FDK---------------------------ALEELEKLKKPffaflITLSN--H-----------------GPYTLPEED 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 248 AHMhVPISRTQLSAVLrgrrpygAGLREMDSLVGQIKDKVD-RTAKENTFLWFTGDngpwaqkcelagsvgpftglwqtH 326
Cdd:COG1368 406 KKI-PDYGKTTLNNYL-------NAVRYADQALGEFIEKLKkSGWYDNTIFVIYGD-----------------------H 454
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115503411 327 QGGSPAKQTTWE--GGHRVPALAYWPGRVPVNVTSTaLLSVLDIFPTVVALAGASLPQDRHF 386
Cdd:COG1368 455 GPRSPGKTDYENplERYRVPLLIYSPGLKKPKVIDT-VGSQIDIAPTLLDLLGIDYPSYYAF 515
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
14-162 |
4.49e-04 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 42.81 E-value: 4.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 14 TFLGCLYPLVDFCPSGeTRGQKPNFVIILADDMGWGDLGANwaetkDTANLDKMAAEGMRFVDFHAA--ASTCsPSRASL 91
Cdd:COG1524 3 RGLSLLLASLLAAAAA-AAPPAKKVVLILVDGLRADLLERA-----HAPNLAALAARGVYARPLTSVfpSTTA-PAHTTL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 92 LTGRLGLRNGVTHNF--------AVTSVGGLP--------LNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPN----FR 151
Cdd:COG1524 76 LTGLYPGEHGIVGNGwydpelgrVVNSLSWVEdgfgsnslLPVPTIFERARAAGLTTAAVFWPSFEGSGLIDAArpypYD 155
|
170
....*....|.
gi 115503411 152 GFDYYFGIPYS 162
Cdd:COG1524 156 GRKPLLGNPAA 166
|
|
| |
