NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|115503411|sp|Q32KH9|]
View 

RecName: Full=Arylsulfatase G; Short=ASG; AltName: Full=N-sulfoglucosamine-3-sulfatase; Flags: Precursor

Protein Classification

alkaline phosphatase family protein( domain architecture ID 10888435)

alkaline phosphatase (ALP) family protein may catalyze the hydrolysis of substrates; the ALP superfamily includes alkaline phosphatases and sulfatases

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ARSG cd16161
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ...
35-469 0e+00

arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.


:

Pssm-ID: 293780 [Multi-domain]  Cd Length: 383  Bit Score: 618.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAET-KDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGG 113
Cdd:cd16161    1 KPNFLLLFADDLGWGDLGANWAPNaILTPNLDKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVGHNFLPTSVGG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHDmgctdtpgynhppcpacprgdrpsrsler 193
Cdd:cd16161   81 LPLNETTLAEVLRQAGYATGMIGKWHLGQREAYLPNSRGFDYYFGIPFSHD----------------------------- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalplyenlniveqpvnlSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPISRTQL-SAVLRGRRPYGAG 272
Cdd:cd16161  132 -----------------------SSLADRYAQFATDFIQRASAKDRPFFLYAALAHVHVPLANLPRfQSPTSGRGPYGDA 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 273 LREMDSLVGQIKDKVDR-TAKENTFLWFTGDNGPWAQKCELAgsVGPFTGLWQTHQGGSPAKQTTWEGGHRVPALAYWPG 351
Cdd:cd16161  189 LQEMDDLVGQIMDAVKHaGLKDNTLTWFTSDNGPWEVKCELA--VGPGTGDWQGNLGGSVAKASTWEGGHREPAIVYWPG 266
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 352 RVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSGAAGeFGALQTVRLGSYKAF 431
Cdd:cd16161  267 RIPANSTSAALVSTLDIFPTVVALAGASLPPGRIYDGKDLSPVLFGGSKTGHRCLFHPNSGAAG-AGALSAVRCGDYKAH 345
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 115503411 432 YVSGGAKACDGDVGREQHHDPPLIFNLEDDVAEAVPLD 469
Cdd:cd16161  346 YATGGALACCGSTGPKLYHDPPLLFDLEVDPAESFPLT 383
 
Name Accession Description Interval E-value
ARSG cd16161
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ...
35-469 0e+00

arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.


Pssm-ID: 293780 [Multi-domain]  Cd Length: 383  Bit Score: 618.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAET-KDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGG 113
Cdd:cd16161    1 KPNFLLLFADDLGWGDLGANWAPNaILTPNLDKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVGHNFLPTSVGG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHDmgctdtpgynhppcpacprgdrpsrsler 193
Cdd:cd16161   81 LPLNETTLAEVLRQAGYATGMIGKWHLGQREAYLPNSRGFDYYFGIPFSHD----------------------------- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalplyenlniveqpvnlSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPISRTQL-SAVLRGRRPYGAG 272
Cdd:cd16161  132 -----------------------SSLADRYAQFATDFIQRASAKDRPFFLYAALAHVHVPLANLPRfQSPTSGRGPYGDA 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 273 LREMDSLVGQIKDKVDR-TAKENTFLWFTGDNGPWAQKCELAgsVGPFTGLWQTHQGGSPAKQTTWEGGHRVPALAYWPG 351
Cdd:cd16161  189 LQEMDDLVGQIMDAVKHaGLKDNTLTWFTSDNGPWEVKCELA--VGPGTGDWQGNLGGSVAKASTWEGGHREPAIVYWPG 266
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 352 RVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSGAAGeFGALQTVRLGSYKAF 431
Cdd:cd16161  267 RIPANSTSAALVSTLDIFPTVVALAGASLPPGRIYDGKDLSPVLFGGSKTGHRCLFHPNSGAAG-AGALSAVRCGDYKAH 345
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 115503411 432 YVSGGAKACDGDVGREQHHDPPLIFNLEDDVAEAVPLD 469
Cdd:cd16161  346 YATGGALACCGSTGPKLYHDPPLLFDLEVDPAESFPLT 383
AslA COG3119
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
34-497 1.74e-87

Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 442353 [Multi-domain]  Cd Length: 393  Bit Score: 274.83  E-value: 1.74e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvTSVGG 113
Cdd:COG3119   22 KRPNILFILADDLGYGDLGCYGNPLIKTPNIDRLAAEGVRFTNAYVTSPVCSPSRASLLTGRYPHRTGVTDNGE-GYNGG 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLghhgpyhpnfrgfdyyfgipyshdmgctdtpgynhppcpacprgdrpsrsler 193
Cdd:COG3119  101 LPPDEPTLAELLKEAGYRTALFGKWHL----------------------------------------------------- 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcYTDvalplyenlniveqpvnlsslaHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPI------------------- 254
Cdd:COG3119  128 --YLT----------------------DLLTDKAIDFLERQADKDKPFFLYLAFNAPHAPYqapeeyldkydgkdiplpp 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 255 ----SRTQLSAVLRGRRPYGAGLREMDSLVGQIKDKVDRT-AKENTFLWFTGDNGPWAQKcelagsvgpftglwQTHQGG 329
Cdd:COG3119  184 nlapRDLTEEELRRARAAYAAMIEEVDDQVGRLLDALEELgLADNTIVVFTSDNGPSLGE--------------HGLRGG 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 330 spaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDrhFDGLDASEVLFGWSQTGHRVLFHp 409
Cdd:COG3119  250 ---KGTLYEGGIRVPLIVRWPGKIKAGSVSDALVSLIDLLPTLLDLAGVPIPED--LDGRSLLPLLTGEKAEWRDYLYW- 323
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 410 nsgAAGEFGALQTVRLGSYKAFYvsggakacdgdvgREQHHDPPLIFNLEDDVAEAVPLdrgSAEYqgvlPKVREILADV 489
Cdd:COG3119  324 ---EYPRGGGNRAIRTGRWKLIR-------------YYDDDGPWELYDLKNDPGETNNL---AADY----PEVVAELRAL 380

                 ....*...
gi 115503411 490 LLDIAGDN 497
Cdd:COG3119  381 LEAWLKEL 388
Sulfatase pfam00884
Sulfatase;
36-378 2.05e-56

Sulfatase;


Pssm-ID: 459979 [Multi-domain]  Cd Length: 298  Bit Score: 190.71  E-value: 2.05e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411   36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNfavtSVGGLP 115
Cdd:pfam00884   1 PNVVLVLGESLRAPDLGLYGYPRPTTPFLDRLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVS----TPVGLP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  116 LNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFG-IPYSHDMGCTDTPGYNHPPcpacprgdrpsrsleRD 194
Cdd:pfam00884  77 RTEPSLPDLLKRAGYNTGAIGKWHLGWYNNQSPCNLGFDKFFGrNTGSDLYADPPDVPYNCSG---------------GG 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  195 CYTDValplyenlniveqpvnlsslahkYAEKAIQFIQHASasgRPFLLYMGLAHMHVP------------ISRTQLSAV 262
Cdd:pfam00884 142 VSDEA-----------------------LLDEALEFLDNND---KPFFLVLHTLGSHGPpyypdrypekyaTFKPSSCSE 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  263 LRGRRPYGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGPwaqkcelagSVGPFTGLWQTHQGGspakqTTWEGGH 341
Cdd:pfam00884 196 EQLLNSYDNTLLYTDDAIGRVLDKLEENGLlDNTLVVYTSDHGE---------SLGEGGGYLHGGKYD-----NAPEGGY 261
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 115503411  342 RVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGA 378
Cdd:pfam00884 262 RVPLLIWSPGGKAKGQKSEALVSHVDLFPTILDLAGI 298
PRK13759 PRK13759
arylsulfatase; Provisional
31-490 1.50e-31

arylsulfatase; Provisional


Pssm-ID: 237491 [Multi-domain]  Cd Length: 485  Bit Score: 127.48  E-value: 1.50e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  31 TRGQKPNFVIILADDMGwGD-LGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLT-------GRLGLRNGV 102
Cdd:PRK13759   2 VQTKKPNIILIMVDQMR-GDcLGCNGNKAVETPNLDMLASEGYNFENAYSAVPSCTPARAALLTglsqwhhGRVGYGDVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 103 THNFavtsvgglplnETTLAEVLQQAGYVTGMIGKWHlghhgpYHP--NFRGFDYYFgipySHDmGCTDTPGYNHPPCPA 180
Cdd:PRK13759  81 PWNY-----------KNTLPQEFRDAGYYTQCIGKMH------VFPqrNLLGFHNVL----LHD-GYLHSGRNEDKSQFD 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 181 CP-------RGDRPSRSLER-----DCYTDVALP--LYENLNiveqPVNLSslahkyAEKAIQFIQHASaSGRPFLLYMG 246
Cdd:PRK13759 139 FVsdylawlREKAPGKDPDLtdigwDCNSWVARPwdLEERLH----PTNWV------GSESIEFLRRRD-PTKPFFLKMS 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 247 LAHMHVPI--------------------------------------SRTQLS--AVLRGRRPYGAGLREMDSLVGQIKDK 286
Cdd:PRK13759 208 FARPHSPYdppkryfdmykdadipdphigdweyaedqdpeggsidaLRGNLGeeYARRARAAYYGLITHIDHQIGRFLQA 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 287 V-DRTAKENTFLWFTGDNGpwaqkcELAGSvgpfTGLWQthqggspaKQTTWEGGHRVPALAYWPG---RVPVNVTSTAL 362
Cdd:PRK13759 288 LkEFGLLDNTIILFVSDHG------DMLGD----HYLFR--------KGYPYEGSAHIPFIIYDPGgllAGNRGTVIDQV 349
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 363 LSVLDIFPTVVALAGASLPQDrhFDGLDASEVLFGwSQTGHRVLFHpnsgaaGEFG----ALQTVRLGSYKAFYVSGgak 438
Cdd:PRK13759 350 VELRDIMPTLLDLAGGTIPDD--VDGRSLKNLIFG-QYEGWRPYLH------GEHAlgysSDNYLTDGKWKYIWFSQ--- 417
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 115503411 439 acdgdVGREQhhdpplIFNLEDDVAEAVPLdRGSAEYQGVLPKVREILADVL 490
Cdd:PRK13759 418 -----TGEEQ------LFDLKKDPHELHNL-SPSEKYQPRLREMRKKLVDHL 457
 
Name Accession Description Interval E-value
ARSG cd16161
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ...
35-469 0e+00

arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.


Pssm-ID: 293780 [Multi-domain]  Cd Length: 383  Bit Score: 618.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAET-KDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGG 113
Cdd:cd16161    1 KPNFLLLFADDLGWGDLGANWAPNaILTPNLDKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVGHNFLPTSVGG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHDmgctdtpgynhppcpacprgdrpsrsler 193
Cdd:cd16161   81 LPLNETTLAEVLRQAGYATGMIGKWHLGQREAYLPNSRGFDYYFGIPFSHD----------------------------- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalplyenlniveqpvnlSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPISRTQL-SAVLRGRRPYGAG 272
Cdd:cd16161  132 -----------------------SSLADRYAQFATDFIQRASAKDRPFFLYAALAHVHVPLANLPRfQSPTSGRGPYGDA 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 273 LREMDSLVGQIKDKVDR-TAKENTFLWFTGDNGPWAQKCELAgsVGPFTGLWQTHQGGSPAKQTTWEGGHRVPALAYWPG 351
Cdd:cd16161  189 LQEMDDLVGQIMDAVKHaGLKDNTLTWFTSDNGPWEVKCELA--VGPGTGDWQGNLGGSVAKASTWEGGHREPAIVYWPG 266
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 352 RVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSGAAGeFGALQTVRLGSYKAF 431
Cdd:cd16161  267 RIPANSTSAALVSTLDIFPTVVALAGASLPPGRIYDGKDLSPVLFGGSKTGHRCLFHPNSGAAG-AGALSAVRCGDYKAH 345
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 115503411 432 YVSGGAKACDGDVGREQHHDPPLIFNLEDDVAEAVPLD 469
Cdd:cd16161  346 YATGGALACCGSTGPKLYHDPPLLFDLEVDPAESFPLT 383
GALNS_like cd16026
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ...
35-468 7.73e-174

galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.


Pssm-ID: 293750 [Multi-domain]  Cd Length: 399  Bit Score: 495.93  E-value: 7.73e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHN-FAVTSVGG 113
Cdd:cd16026    1 KPNIVVILADDLGYGDLGCYGSPLIKTPNIDRLAAEGVRFTDFYAAAPVCSPSRAALLTGRYPVRVGLPGVvGPPGSKGG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPAcprgdrpsrsler 193
Cdd:cd16026   81 LPPDEITIAEVLKKAGYRTALVGKWHLGHQPEFLPTRHGFDEYFGIPYSNDMWPFPLYRNDPPGPLP------------- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalPLYENLNIVEQPVNLSSLAHKYAEKAIQFIQhaSASGRPFLLYMGLAHMHVPISRTQLSAVLRGRRPYGAGL 273
Cdd:cd16026  148 --------PLMENEEVIEQPADQSSLTQRYTDEAVDFIE--RNKDQPFFLYLAHTMPHVPLFASEKFKGRSGAGLYGDVV 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 274 REMDSLVGQIKDKVDRT-AKENTFLWFTGDNGPWAQKCELAGSVGPFTGlwqthqggspAKQTTWEGGHRVPALAYWPGR 352
Cdd:cd16026  218 EELDWSVGRILDALKELgLEENTLVIFTSDNGPWLEYGGHGGSAGPLRG----------GKGTTWEGGVRVPFIAWWPGV 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 353 VPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSGaagefGALQTVRLGSYKAFY 432
Cdd:cd16026  288 IPAGTVSDELASTMDLLPTLAALAGAPLPEDRVIDGKDISPLLLGGSKSPPHPFFYYYDG-----GDLQAVRSGRWKLHL 362
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 115503411 433 VSGGAKACDGDVGREQHHDPPLIFNLEDDVAEAVPL 468
Cdd:cd16026  363 PTTYRTGTDPGGLDPTKLEPPLLYDLEEDPGETYNV 398
ARSA cd16158
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ...
35-515 1.51e-119

Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.


Pssm-ID: 293777 [Multi-domain]  Cd Length: 479  Bit Score: 360.61  E-value: 1.51e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHN-FAVTSVGG 113
Cdd:cd16158    1 PPNIVLLFADDLGYGDLGCYGHPSSSTPNLDRLAANGLRFTDFYSSSPVCSPSRAALLTGRYQVRSGVYPGvFYPGSRGG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHL--GHHGPYHPNFRGFDYYFGIPYSHDMG-CTDTPGYnhPPCPACPRGDRPSrs 190
Cdd:cd16158   81 LPLNETTIAEVLKTVGYQTAMVGKWHLgvGLNGTYLPTHQGFDHYLGIPYSHDQGpCQNLTCF--PPNIPCFGGCDQG-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 191 lerdcytDVALPLYENLNIVEQPVNLSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPISRTQLSAVLRGRRPYG 270
Cdd:cd16158  157 -------EVPCPLFYNESIVQQPVDLLTLEERYAKFAKDFIADNAKEGKPFFLYYASHHTHYPQFAGQKFAGRSSRGPFG 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 271 AGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGPWAQKCELAGSvgpfTGLWQTHQGgspakqTTWEGGHRVPALAYW 349
Cdd:cd16158  230 DALAELDGSVGELLQTLKENGiDNNTLVFFTSDNGPSTMRKSRGGN----AGLLKCGKG------TTYEGGVREPAIAYW 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 350 PGRVPVNVTStALLSVLDIFPTVVALAGASLPqDRHFDGLDASEVLFGWSQTGHRVLFHPNSGAAGEFGALqTVRLGSYK 429
Cdd:cd16158  300 PGRIKPGVTH-ELASTLDILPTIAKLAGAPLP-NVTLDGVDMSPILFEQGKSPRQTFFYYPTSPDPDKGVF-AVRWGKYK 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 430 AFYVSGGA--------KACDGDVGReQHHDPPLIFNLEDDVAEAVPLDRGSaEYQGVLPKVREILADVLLDIA-GDntSR 500
Cdd:cd16158  377 AHFYTQGAahsgttpdKDCHPSAEL-TSHDPPLLFDLSQDPSENYNLLGLP-EYNQVLKQIQQVKERFEASMKfGE--SE 452
                        490
                 ....*....|....*
gi 115503411 501 ADYTRHPSVTPCCNP 515
Cdd:cd16158  453 INKGEDPALEPCCKP 467
spARS_like cd16160
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ...
35-468 7.12e-113

sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293779 [Multi-domain]  Cd Length: 445  Bit Score: 342.10  E-value: 7.12e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGV---THNFAVTSV 111
Cdd:cd16160    1 KPNIVLFFADDMGYGDLASYGHPTQERGPIDDMAAEGIRFTQAYSADSVCTPSRAALLTGRLPIRSGMyggTRVFLPWDI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 112 GGLPLNETTLAEVLQQAGYVTGMIGKWHLG-----HHGPYH-PNFRGFDYY-FGIPYSHDMGCTDTPGYNhppcpacprg 184
Cdd:cd16160   81 GGLPKTEVTMAEALKEAGYTTGMVGKWHLGinennHSDGAHlPSHHGFDFVgTNLPFTNSWACDDTGRHV---------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 185 DRPSRSLerdCYtdvalpLYENLNIVEQPVNLSSLAHKYAEKAIQFIqHASASgRPFLLYMGLAHMHVPI--SRTQLSAV 262
Cdd:cd16160  151 DFPDRSA---CF------LYYNDTIVEQPIQHEHLTETLVGDAKSFI-EDNQE-NPFFLYFSFPQTHTPLfaSKRFKGKS 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 263 LRGRrpYGAGLREMDSLVGQIKDK-VDRTAKENTFLWFTGDNGPWAQKCELAGSVGPFTGlwqthqggspAKQTTWEGGH 341
Cdd:cd16160  220 KRGR--YGDNINEMSWAVGEVLDTlVDTGLDQNTLVFFLSDHGPHVEYCLEGGSTGGLKG----------GKGNSWEGGI 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 342 RVPALAYWPGRVPVNVtSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHR-VLFHPNSgaagefgAL 420
Cdd:cd16160  288 RVPFIAYWPGTIKPRV-SHEVVSTMDIFPTFVDLAGGTLPTDRIYDGLSITDLLLGEADSPHDdILYYCCS-------RL 359
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115503411 421 QTVRLGSYKAFYVSGG-------AKACDGDVGREQH-------------HDPPLIFNLEDDVAEAVPL 468
Cdd:cd16160  360 MAVRYGSYKIHFKTQPlpsqeslDPNCDGGGPLSDYivcydcedecvtkHNPPLIFDVEKDPGEQYPL 427
GALNS cd16157
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ...
35-488 1.23e-104

galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.


Pssm-ID: 293776 [Multi-domain]  Cd Length: 466  Bit Score: 321.72  E-value: 1.23e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNG--VTHNFAVTS-- 110
Cdd:cd16157    1 KPNIILMLMDDMGWGDLGVFGEPSRETPNLDRMAAEGMLFTDFYSANPLCSPSRAALLTGRLPIRNGfyTTNAHARNAyt 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 111 ----VGGLPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHdMGCTDTPgynhppcpacprgDR 186
Cdd:cd16157   81 pqniVGGIPDSEILLPELLKKAGYRNKIVGKWHLGHRPQYHPLKHGFDEWFGAPNCH-FGPYDNK-------------AY 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 187 PSRSLERDcyTDVALPLYENLNIvEQPVNLSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPI--SRTQLSAVLR 264
Cdd:cd16157  147 PNIPVYRD--WEMIGRYYEEFKI-DKKTGESNLTQIYLQEALEFIEKQHDAQKPFFLYWAPDATHAPVyaSKPFLGTSQR 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 265 GRrpYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNG-PWAQKCELAGSVGPFTGlwqthqggspAKQTTWEGGHR 342
Cdd:cd16157  224 GL--YGDAVMELDSSVGKILESLKSLGiENNTFVFFSSDNGaALISAPEQGGSNGPFLC----------GKQTTFEGGMR 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 343 VPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSgaagefgALQT 422
Cdd:cd16157  292 EPAIAWWPGHIKPGQVSHQLGSLMDLFTTSLALAGLPIPSDRAIDGIDLLPVLLNGKEKDRPIFYYRGD-------ELMA 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 423 VRLGSYKAFY---------VSGGAKACDG-DVG------REQHHDPPLIFNLEDDVAEAVPLDRGSAEYQGVLPKVREIL 486
Cdd:cd16157  365 VRLGQYKAHFwtwsnsweeFRKGINFCPGqNVPgvtthnQTDHTKLPLLFHLGRDPGEKYPISFKSAEYKQAMPRISKVV 444

                 ..
gi 115503411 487 AD 488
Cdd:cd16157  445 QQ 446
ES cd16159
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ...
35-488 2.03e-102

Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.


Pssm-ID: 293778 [Multi-domain]  Cd Length: 521  Bit Score: 317.69  E-value: 2.03e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHN------FAV 108
Cdd:cd16159    1 KPNIVLFMADDLGIGDVGCFGNDTIRTPNIDRLAKEGVKLTHHLAAAPLCTPSRAAFLTGRYPIRSGMASShgmrviLFT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 109 TSVGGLPLNETTLAEVLQQAGYVTGMIGKWHLGHH------GPYHPNFRGFDYYFGIPYSHDMGCTDTPG----YNHPP- 177
Cdd:cd16159   81 ASSGGLPPNETTFAEVLKQQGYSTALIGKWHLGLHcesrndFCHHPLNHGFDYFYGLPLTNLKDCGDGSNgeydLSFDPl 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 178 -------CPAC-----------PRGDRPSRSLERDCYTDVALP-------------LYENLNIVEQPVNLSSLAHKYAEK 226
Cdd:cd16159  161 fplltafVLITaltiflllylgAVSKRFFVFLLILSLLFISLFflllitnryfnciLMRNHEVVEQPMSLENLTQRLTKE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 227 AIQFIQhaSASGRPFLLYMGLAHMHVPISRTQLsavLRGRR---PYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGD 302
Cdd:cd16159  241 AISFLE--RNKERPFLLVMSFLHVHTALFTSKK---FKGRSkhgRYGDNVEEMDWSVGQILDALDELGlKDNTFVYFTSD 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 303 NGPWAqkcELAGSVGPFTGLWQTHQGGSpaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQ 382
Cdd:cd16159  316 NGGHL---EEISVGGEYGGGNGGIYGGK--KMGGWEGGIRVPTIVRWPGVIPPGSVIDEPTSLMDIFPTVAALAGAPLPS 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 383 DRHFDGLDASEVLFGWSQ-TGHRVLFH------------PNSGAAgefgalqtvrlgSYKAFYVS----GGAKACDG--- 442
Cdd:cd16159  391 DRIIDGRDLMPLLTGQEKrSPHEFLFHycgaelhavryrPRDGGA------------VWKAHYFTpnfyPGTEGCCGtll 458
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 115503411 443 ---DVGREQHHDPPLIFNLEDDVAEAVPLDRGSAEYQGVLPKVREILAD 488
Cdd:cd16159  459 crcFGDSVTHHDPPLLFDLSADPSESNPLDPTDEPYQEIIKKILEAVAE 507
ARS_like cd16142
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
36-461 2.69e-92

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293761 [Multi-domain]  Cd Length: 372  Bit Score: 286.74  E-value: 2.69e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGAN---WAETKDTANLDKMAAEGMRFVDFHAAAStCSPSRASLLTGRLGLRNGVTHNFAVTSVG 112
Cdd:cd16142    1 PNILVILGDDIGWGDLGCYgggIGRGAPTPNIDRLAKEGLRFTSFYVEPS-CTPGRAAFITGRHPIRTGLTTVGLPGSPG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 113 GLPLNETTLAEVLQQAGYVTGMIGKWHLGHHgPYH-PNFRGFDYYFGIPYSHDmgctdtpgynhppcpacprgdrpsrsl 191
Cdd:cd16142   80 GLPPWEPTLAELLKDAGYATAQFGKWHLGDE-DGRlPTDHGFDEFYGNLYHTI--------------------------- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 192 erDCYtdvalplyenlniveqpvnlsslahkYAEKAIQFIQHASASGRPFLLYMGLAHMHVPIS-RTQLSAVLRGRRPYG 270
Cdd:cd16142  132 --DEE--------------------------IVDKAIDFIKRNAKADKPFFLYVNFTKMHFPTLpSPEFEGKSSGKGKYA 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 271 AGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGPWAQKCELAGSvGPFTGlwqthqggspAKQTTWEGGHRVPALAYW 349
Cdd:cd16142  184 DSMVELDDHVGQILDALDELGiADNTIVIFTTDNGPEQDVWPDGGY-TPFRG----------EKGTTWEGGVRVPAIVRW 252
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 350 PGRVPVNVTSTALLSVLDIFPTVVALAGASLP------QDRHFDGLDASEVLFGWS-QTGHRVLFHpnsGAAGEFGAlqt 422
Cdd:cd16142  253 PGKIKPGRVSNEIVSHLDWFPTLAALAGAPDPkdkllgKDRHIDGVDQSPFLLGKSeKSRRSEFFY---FGEGELGA--- 326
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 115503411 423 VRLGSYKA-FYVSGGAKAcdGDVGREQHHDPPLIFNLEDD 461
Cdd:cd16142  327 VRWKNWKVhFKAQEDTGG--PTGEPFYVLTFPLIFNLRRD 364
AslA COG3119
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
34-497 1.74e-87

Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 442353 [Multi-domain]  Cd Length: 393  Bit Score: 274.83  E-value: 1.74e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvTSVGG 113
Cdd:COG3119   22 KRPNILFILADDLGYGDLGCYGNPLIKTPNIDRLAAEGVRFTNAYVTSPVCSPSRASLLTGRYPHRTGVTDNGE-GYNGG 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLghhgpyhpnfrgfdyyfgipyshdmgctdtpgynhppcpacprgdrpsrsler 193
Cdd:COG3119  101 LPPDEPTLAELLKEAGYRTALFGKWHL----------------------------------------------------- 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcYTDvalplyenlniveqpvnlsslaHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVPI------------------- 254
Cdd:COG3119  128 --YLT----------------------DLLTDKAIDFLERQADKDKPFFLYLAFNAPHAPYqapeeyldkydgkdiplpp 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 255 ----SRTQLSAVLRGRRPYGAGLREMDSLVGQIKDKVDRT-AKENTFLWFTGDNGPWAQKcelagsvgpftglwQTHQGG 329
Cdd:COG3119  184 nlapRDLTEEELRRARAAYAAMIEEVDDQVGRLLDALEELgLADNTIVVFTSDNGPSLGE--------------HGLRGG 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 330 spaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDrhFDGLDASEVLFGWSQTGHRVLFHp 409
Cdd:COG3119  250 ---KGTLYEGGIRVPLIVRWPGKIKAGSVSDALVSLIDLLPTLLDLAGVPIPED--LDGRSLLPLLTGEKAEWRDYLYW- 323
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 410 nsgAAGEFGALQTVRLGSYKAFYvsggakacdgdvgREQHHDPPLIFNLEDDVAEAVPLdrgSAEYqgvlPKVREILADV 489
Cdd:COG3119  324 ---EYPRGGGNRAIRTGRWKLIR-------------YYDDDGPWELYDLKNDPGETNNL---AADY----PEVVAELRAL 380

                 ....*...
gi 115503411 490 LLDIAGDN 497
Cdd:COG3119  381 LEAWLKEL 388
ARS_like cd16144
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
36-465 4.47e-87

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293763 [Multi-domain]  Cd Length: 421  Bit Score: 274.81  E-value: 4.47e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNF--------- 106
Cdd:cd16144    1 PNIVLILVDDLGWADLGCYGSKFYETPNIDRLAKEGMRFTQAYAAAPVCSPSRASILTGQYPARLGITDVIpgrrgppdn 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 107 ----AVTSVGGLPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGI-PYSHDMGCTDTPGYNHPPCPAC 181
Cdd:cd16144   81 tkliPPPSTTRLPLEEVTIAEALKDAGYATAHFGKWHLGGEGGYGPEDQGFDVNIGGtGNGGPPSYYFPPGKPNPDLEDG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 182 PRGDRPSRSLerdcytdvalplyenlniveqpvnlsslahkyAEKAIQFIQhaSASGRPFLLYmgLAH--MHVPI-SRTQ 258
Cdd:cd16144  161 PEGEYLTDRL--------------------------------TDEAIDFIE--QNKDKPFFLY--LSHyaVHTPIqARPE 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 259 LSAVLRGRRP----------YGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGPWAQKCELAGSVGPFTGlwqthq 327
Cdd:cd16144  205 LIEKYEKKKKglrkgqknpvYAAMIESLDESVGRILDALEELGlADNTLVIFTSDNGGLSTRGGPPTSNAPLRG------ 278
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 328 ggspAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHR--V 405
Cdd:cd16144  279 ----GKGSLYEGGIRVPLIVRWPGVIKPGSVSDVPVIGTDLYPTFLELAGGPLPPPQHLDGVSLVPLLKGGEADLPRraL 354
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115503411 406 LFH-PN-SGAAGEFGAlqTVRLGSYK--AFYVSGGAKacdgdvgreqhhdpplIFNLEDDVAEA 465
Cdd:cd16144  355 FWHfPHyHGQGGRPAS--AIRKGDWKliEFYEDGRVE----------------LYNLKNDIGET 400
ARS_like cd16143
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
36-464 1.65e-82

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293762 [Multi-domain]  Cd Length: 395  Bit Score: 262.14  E-value: 1.65e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETK-DTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNfaVTSVGGL 114
Cdd:cd16143    1 PNIVIILADDLGYGDISCYNPDSKiPTPNIDRLAAEGMRFTDAHSPSSVCTPSRYGLLTGRYPWRSRLKGG--VLGGFSP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 PL---NETTLAEVLQQAGYVTGMIGKWHLG---------HHGPYH-------------PNFRGFDYYFGIPYShdmgctd 169
Cdd:cd16143   79 PLiepDRVTLAKMLKQAGYRTAMVGKWHLGldwkkkdgkKAATGTgkdvdyskpikggPLDHGFDYYFGIPAS------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 170 tpgynhppcpacprgdrpsrslerdcytDVaLPLyenlniveqpvnlsslahkYAEKAIQFIQHASASGRPFLLYMGLAH 249
Cdd:cd16143  152 ----------------------------EV-LPT-------------------LTDKAVEFIDQHAKKDKPFFLYFALPA 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 250 MHVPIS-------RTQLSavlrgrrPYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGP----WAQKCELAG--S 315
Cdd:cd16143  184 PHTPIVpspefqgKSGAG-------PYGDFVYELDWVVGRILDALKELGlAENTLVIFTSDNGPspyaDYKELEKFGhdP 256
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 316 VGPFTGLwqthqggspaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVL 395
Cdd:cd16143  257 SGPLRGM----------KADIYEGGHRVPFIVRWPGKIPAGSVSDQLVSLTDLFATLAAIVGQKLPDNAAEDSFSFLPAL 326
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115503411 396 FGWSQTGHRV-LFHpnSGAAGEFgalqTVRLGSYKaFYVSGGAKACDGDVGREQHHDPP-LIFNLEDDVAE 464
Cdd:cd16143  327 LGPKKQEVREsLVH--HSGNGSF----AIRKGDWK-LIDGTGSGGFSYPRGKEKLGLPPgQLYNLSTDPGE 390
ARS_like cd16146
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ...
36-464 7.12e-77

uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293765 [Multi-domain]  Cd Length: 409  Bit Score: 247.85  E-value: 7.12e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAaSTCSPSRASLLTGRLGLRNGVTHnfavTSVGG-- 113
Cdd:cd16146    1 PNVILILTDDQGYGDLGFHGNPILKTPNLDRLAAESVRFTNFHVS-PVCAPTRAALLTGRYPFRTGVWH----TILGRer 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIPYSHDmgcTDTPGY--NHPPCPACPRGDRPSRSl 191
Cdd:cd16146   76 MRLDETTLAEVFKDAGYRTGIFGKWHLGDNYPYRPQDRGFDEVLGHGGGGI---GQYPDYwgNDYFDDTYYHNGKFVKT- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 192 ERDCyTDValplyenlniveqpvnlsslahkYAEKAIQFIQhaSASGRPFLLYMGLAHMHVPIS-RTQLSAvlrgrRPYG 270
Cdd:cd16146  152 EGYC-TDV-----------------------FFDEAIDFIE--ENKDKPFFAYLATNAPHGPLQvPDKYLD-----PYKD 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 271 AGLRE-----------MDSLVGQIKDKVDRT-AKENTFLWFTGDNGPWaqkcelagsvGPFTGLWQTHQGGSpaKQTTWE 338
Cdd:cd16146  201 MGLDDklaafygmienIDDNVGRLLAKLKELgLEENTIVIFMSDNGPA----------GGVPKRFNAGMRGK--KGSVYE 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 339 GGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQ-TGHRVLF-HPNSGAAGE 416
Cdd:cd16146  269 GGHRVPFFIRWPGKILAGKDVDTLTAHIDLLPTLLDLCGVKLPEGIKLDGRSLLPLLKGESDpWPERTLFtHSGRWPPPP 348
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 115503411 417 FG-ALQTVRLGSYKafYVSGgakacdgdvgreqHHDPPLIFNLEDDVAE 464
Cdd:cd16146  349 KKkRNAAVRTGRWR--LVSP-------------KGFQPELYDIENDPGE 382
ARS_like cd16145
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
36-464 1.86e-75

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293764 [Multi-domain]  Cd Length: 415  Bit Score: 244.43  E-value: 1.86e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGGLP 115
Cdd:cd16145    1 PNIIFILADDLGYGDLGCYGQKKIKTPNLDRLAAEGMRFTQHYAGAPVCAPSRASLLTGLHTGHTRVRGNSEPGGQDPLP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHLG-HHGPYHPNFRGFDYYFGIpYSHdmgctdTPGYNH-PPcpacprgdrpsrSLER 193
Cdd:cd16145   81 PDDVTLAEVLKKAGYATAAFGKWGLGgPGTPGHPTKQGFDYFYGY-LDQ------VHAHNYyPE------------YLWR 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 DcytDVALPLYENLNIVEQPVNLSSLAHK-YAE-----KAIQFIQ-HASasgRPFLLYMGL----AHMHVP--------- 253
Cdd:cd16145  142 N---GEKVPLPNNVIPPLDEGNNAGGGGGtYSHdlftdEALDFIReNKD---KPFFLYLAYtlphAPLQVPddgpykykp 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 254 --ISRTQLSAVLRGRRPYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGP-----WAQKCELAGSVGPFTGLwqt 325
Cdd:cd16145  216 kdPGIYAYLPWPQPEKAYAAMVTRLDRDVGRILALLKELGiDENTLVVFTSDNGPhseggSEHDPDFFDSNGPLRGY--- 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 326 hqggspaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDrhFDGLDASEVLFGWS-QTGHR 404
Cdd:cd16145  293 -------KRSLYEGGIRVPFIARWPGKIPAGSVSDHPSAFWDFMPTLADLAGAEPPED--IDGISLLPTLLGKPqQQQHD 363
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 405 VLFHpnsgAAGEFGALQTVRLGSYKAFYVSGGAkacdgdvgreqhhDPPLIFNLEDDVAE 464
Cdd:cd16145  364 YLYW----EFYEGGGAQAVRMGGWKAVRHGKKD-------------GPFELYDLSTDPGE 406
sulfatase_like cd16022
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ...
36-390 6.24e-69

sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293746 [Multi-domain]  Cd Length: 236  Bit Score: 221.54  E-value: 6.24e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNfaVTSVGGLP 115
Cdd:cd16022    1 PNILLIMTDDLGYDDLGCYGNPDIKTPNLDRLAAEGVRFTNAYVASPVCSPSRASLLTGRYPHRHGVRGN--VGNGGGLP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHlghhgpyhpnfrgfdyyfgipyshdmgctdtpgynhppcpacprgdrpsrslerdc 195
Cdd:cd16022   79 PDEPTLAELLKEAGYRTALIGKWH-------------------------------------------------------- 102
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 196 ytdvalplyenlniveqpvnlsslahkyaEKAIQFIQHASASgRPFLLYMGLAHMHVPISrtqlsavlrgrrpYGAGLRE 275
Cdd:cd16022  103 -----------------------------DEAIDFIERRDKD-KPFFLYVSFNAPHPPFA-------------YYAMVSA 139
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 276 MDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcelaGSVGPFTGLWQthqggspaKQTTWEGGHRVPALAYWPGRVP 354
Cdd:cd16022  140 IDDQIGRILDALEELGLlDNTLIVFTSDHG---------DMLGDHGLRGK--------KGSLYEGGIRVPFIVRWPGKIP 202
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 115503411 355 VNVTSTALLSVLDIFPTVVALAGASLPqdRHFDGLD 390
Cdd:cd16022  203 AGQVSDALVSLLDLLPTLLDLAGIEPP--EGLDGRS 236
4-S cd16029
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ...
36-390 3.53e-64

N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.


Pssm-ID: 293753 [Multi-domain]  Cd Length: 393  Bit Score: 214.34  E-value: 3.53e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFvDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSV-GGL 114
Cdd:cd16029    1 PHIVFILADDLGWNDVGFHGSDQIKTPNLDALAADGVIL-NNYYVQPICTPSRAALMTGRYPIHTGMQHGVILAGEpYGL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 PLNETTLAEVLQQAGYVTGMIGKWHLGHHGPYH-PNFRGFDYYFGiPYShdmGCTDtpGYNHPPCPACPRGDRPSRSLE- 192
Cdd:cd16029   80 PLNETLLPQYLKELGYATHLVGKWHLGFYTWEYtPTNRGFDSFYG-YYG---GAED--YYTHTSGGANDYGNDDLRDNEe 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 193 -----RDCYTdvalplyenlniveqpvnlsslAHKYAEKAIQFIQHASASgRPFLLYMGLAHMHVPISRTQLSAVL---- 263
Cdd:cd16029  154 pawdyNGTYS----------------------TDLFTDRAVDIIENHDPS-KPLFLYLAFQAVHAPLQVPPEYADPyedk 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 264 ------RGRRPYGAGLREMDSLVGQIKDK-VDRTAKENTFLWFTGDNGPWAQKCElAGSVGPFTGlwqthqggspAKQTT 336
Cdd:cd16029  211 fahikdEDRRTYAAMVSALDESVGNVVDAlKAKGMLDNTLIVFTSDNGGPTGGGD-GGSNYPLRG----------GKNTL 279
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 115503411 337 WEGGHRVPALAYWPGRVPV-NVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLD 390
Cdd:cd16029  280 WEGGVRVPAFVWSPLLPPKrGTVSDGLMHVTDWLPTLLSLAGGDPDDLPPLDGVD 334
sulfatase_like cd16151
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
36-429 2.67e-61

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293770 [Multi-domain]  Cd Length: 377  Bit Score: 206.30  E-value: 2.67e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAAStCSPSRASLLTGRLGLRNGVTHnfavtsvGGLP 115
Cdd:cd16151    1 PNIILIMADDLGYECIGCYGGESYKTPNIDALAAEGVRFNNAYAQPL-CTPSRVQLMTGKYNFRNYVVF-------GYLD 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHLG---HHGPYHPNFrGFDYYFGIPYSHdmgcTDTPGYNHPPcpacprgdrpsrsLE 192
Cdd:cd16151   73 PKQKTFGHLLKDAGYATAIAGKWQLGggrGDGDYPHEF-GFDEYCLWQLTE----TGEKYSRPAT-------------PT 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 193 RDCYTDVALPLYENlniveqpvnlsslahKY-----AEKAIQFIQHASAsgRPFLLY--MGLAH---MHVPISR-TQLSA 261
Cdd:cd16151  135 FNIRNGKLLETTEG---------------DYgpdlfADFLIDFIERNKD--QPFFAYypMVLVHdpfVPTPDSPdWDPDD 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 262 VLRGRRP--YGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNgpwaqkcelaGSVGPFTGLW--QTHQGGspaKQTT 336
Cdd:cd16151  198 KRKKDDPeyFPDMVAYMDKLVGKLVDKLEELGlRENTIIIFTGDN----------GTHRPITSRTngREVRGG---KGKT 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 337 WEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLDASEVLFGWSQTGHRVLFHPNSGAAGE 416
Cdd:cd16151  265 TDAGTHVPLIVNWPGLIPAGGVSDDLVDFSDFLPTLAELAGAPLPEDYPLDGRSFAPQLLGKTGSPRREWIYWYYRNPHK 344
                        410
                 ....*....|...
gi 115503411 417 FGALQTVRLGSYK 429
Cdd:cd16151  345 KFGSRFVRTKRYK 357
Sulfatase pfam00884
Sulfatase;
36-378 2.05e-56

Sulfatase;


Pssm-ID: 459979 [Multi-domain]  Cd Length: 298  Bit Score: 190.71  E-value: 2.05e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411   36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNfavtSVGGLP 115
Cdd:pfam00884   1 PNVVLVLGESLRAPDLGLYGYPRPTTPFLDRLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVS----TPVGLP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  116 LNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPNFRGFDYYFG-IPYSHDMGCTDTPGYNHPPcpacprgdrpsrsleRD 194
Cdd:pfam00884  77 RTEPSLPDLLKRAGYNTGAIGKWHLGWYNNQSPCNLGFDKFFGrNTGSDLYADPPDVPYNCSG---------------GG 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  195 CYTDValplyenlniveqpvnlsslahkYAEKAIQFIQHASasgRPFLLYMGLAHMHVP------------ISRTQLSAV 262
Cdd:pfam00884 142 VSDEA-----------------------LLDEALEFLDNND---KPFFLVLHTLGSHGPpyypdrypekyaTFKPSSCSE 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  263 LRGRRPYGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGPwaqkcelagSVGPFTGLWQTHQGGspakqTTWEGGH 341
Cdd:pfam00884 196 EQLLNSYDNTLLYTDDAIGRVLDKLEENGLlDNTLVVYTSDHGE---------SLGEGGGYLHGGKYD-----NAPEGGY 261
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 115503411  342 RVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGA 378
Cdd:pfam00884 262 RVPLLIWSPGGKAKGQKSEALVSHVDLFPTILDLAGI 298
PAS_like cd16025
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ...
34-468 1.08e-54

Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293749 [Multi-domain]  Cd Length: 402  Bit Score: 189.19  E-value: 1.08e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  34 QKPNFVIILADDMGWGDLGANWAETkDTANLDKMAAEGMRFVDFHAAAsTCSPSRASLLTGRLGLRNGV-THNFAVTSVG 112
Cdd:cd16025    1 GRPNILLILADDLGFSDLGCFGGEI-PTPNLDALAAEGLRFTNFHTTA-LCSPTRAALLTGRNHHQVGMgTMAELATGKP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 113 G----LPLNETTLAEVLQQAGYVTGMIGKWHLGHHgpyhpnfrgfDYYFgipySHDmgctdtpgynhppcpacprgdrps 188
Cdd:cd16025   79 GyegyLPDSAATIAEVLKDAGYHTYMSGKWHLGPD----------DYYS----TDD------------------------ 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 189 rslerdcytdvalplyenlniveqpvnlsslahkYAEKAIQFIQHASASGRPFLLYM--GLAH--MHVP---ISR----- 256
Cdd:cd16025  121 ----------------------------------LTDKAIEYIDEQKAPDKPFFLYLafGAPHapLQAPkewIDKykgky 166
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 257 ------------------------TQLSAVLRGRRP------------------YGAGLREMDSLVGQIKDKVDRTAK-E 293
Cdd:cd16025  167 dagwdalreerlerqkelglipadTKLTPRPPGVPAwdslspeekklearrmevYAAMVEHMDQQIGRLIDYLKELGElD 246
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 294 NTFLWFTGDNGP-----WAQkcelAGSvGPFTGlwqthqggspAKQTTWEGGHRVPALAYWPGRV-PVNVTSTALLSVLD 367
Cdd:cd16025  247 NTLIIFLSDNGAsaepgWAN----ASN-TPFRL----------YKQASHEGGIRTPLIVSWPKGIkAKGGIRHQFAHVID 311
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 368 IFPTVVALAGASLPQDRH------FDGLDASEVLFG-WSQTGHRVLFHPNSGAAGefgalqtVRLGSYKAFYVSGGAkac 440
Cdd:cd16025  312 IAPTILELAGVEYPKTVNgvpqlpLDGVSLLPTLDGaAAPSRRRTQYFELFGNRA-------IRKGGWKAVALHPPP--- 381
                        490       500
                 ....*....|....*....|....*...
gi 115503411 441 dGDVGREQhhdpplIFNLEDDVAEAVPL 468
Cdd:cd16025  382 -GWGDQWE------LYDLAKDPSETHDL 402
sulfatase_like cd16034
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
35-461 2.04e-50

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293758 [Multi-domain]  Cd Length: 399  Bit Score: 177.76  E-value: 2.04e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVtsvggL 114
Cdd:cd16034    1 KPNILFIFADQHRAQALGCAGDDPVKTPNLDRLAKEGVVFTNAVSNYPVCSPYRASLLTGQYPLTNGVFGNDVP-----L 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 PLNETTLAEVLQQAGYVTGMIGKWHL-GHHGPYH--------PNFR-GFDYYFGipyshdMGCTDtpGYNHPpcpacPRG 184
Cdd:cd16034   76 PPDAPTIADVLKDAGYRTGYIGKWHLdGPERNDGraddytppPERRhGFDYWKG------YECNH--DHNNP-----HYY 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 185 DRPSRSLERDCYTDVALplyenlniveqpvnlsslahkyAEKAIQFIQHASASGRPFLLY--MGLAH------------M 250
Cdd:cd16034  143 DDDGKRIYIKGYSPDAE----------------------TDLAIEYLENQADKDKPFALVlsWNPPHdpyttapeeyldM 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 251 H----------VPISRTQLSAVLRGRRPYGAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGpwaqkcELAGSvgpf 319
Cdd:cd16034  201 YdpkklllrpnVPEDKKEEAGLREDLRGYYAMITALDDNIGRLLDALKELGlLENTIVVFTSDHG------DMLGS---- 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 320 tglwqtHqgGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGasLPQDRHFDGLDASEVLFGWS 399
Cdd:cd16034  271 ------H--GLMNKQVPYEESIRVPFIIRYPGKIKAGRVVDLLINTVDIMPTLLGLCG--LPIPDTVEGRDLSPLLLGGK 340
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115503411 400 QTGHR----VLFHPNSG-AAGEFGALQTVRLGSYKafYVsggakaCDGDvgreqhhDPPLIFNLEDD 461
Cdd:cd16034  341 DDEPDsvllQCFVPFGGgSARDGGEWRGVRTDRYT--YV------RDKN-------GPWLLFDNEKD 392
SGSH cd16027
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ...
36-407 6.23e-50

N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.


Pssm-ID: 293751 [Multi-domain]  Cd Length: 373  Bit Score: 175.77  E-value: 6.23e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGA--NWAETkdtANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFavTSVGG 113
Cdd:cd16027    1 PNILWIIADDLSPDLGGYggNVVKT---PNLDRLAAEGVRFTNAFTTAPVCSPSRSALLTGLYPHQNGAHGLR--SRGFP 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWhlghHGPYHPNFRGFDYYFGIPYSHDMgctdtpgynhppcpacprgdrpsrsler 193
Cdd:cd16027   76 LPDGVKTLPELLREAGYYTGLIGKT----HYNPDAVFPFDDEMRGPDDGGRN---------------------------- 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalplyenlniveqpvnlsslAHKYAEKAIQFIQHAsASGRPFLLYMGLAHMHVPisRTQLSAVLRGRRP----- 268
Cdd:cd16027  124 --------------------------AWDYASNAADFLNRA-KKGQPFFLWFGFHDPHRP--YPPGDGEEPGYDPekvkv 174
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 269 ----------------YGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcelagsvGPFTGlwqthqggsp 331
Cdd:cd16027  175 ppylpdtpevredladYYDEIERLDQQVGEILDELEEDGLlDNTIVIFTSDHG------------MPFPR---------- 232
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115503411 332 AKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQdrHFDGLDASEVLFGWSQTGHRVLF 407
Cdd:cd16027  233 AKGTLYDSGLRVPLIVRWPGKIKPGSVSDALVSFIDLAPTLLDLAGIEPPE--YLQGRSFLPLLKGEKDPGRDYVF 306
G6S_like cd16031
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ...
34-407 1.01e-42

unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.


Pssm-ID: 293755 [Multi-domain]  Cd Length: 429  Bit Score: 157.69  E-value: 1.01e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvtsvGG 113
Cdd:cd16031    1 KRPNIIFILTDDHRYDALGCYGNPIVKTPNIDRLAKEGVRFDNAFVTTSICAPSRASILTGQYSHRHGVTDNNG----PL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGpYHPNfRGFDYYFGIPyshdmGctdtPGYNHPPCPACPRGDRPSRSLER 193
Cdd:cd16031   77 FDASQPTYPKLLRKAGYQTAFIGKWHLGSGG-DLPP-PGFDYWVSFP-----G----QGSYYDPEFIENGKRVGQKGYVT 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 DCYTDVALPLYENlNIVEQPVNLsSLAHK---------------YAEKAIQFIQHAS---ASGRPFLLYMGLAHMHVPIS 255
Cdd:cd16031  146 DIITDKALDFLKE-RDKDKPFCL-SLSFKaphrpftpaprhrglYEDVTIPEPETFDdddYAGRPEWAREQRNRIRGVLD 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 256 RTQLS--AVLRGRRPYGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcelagsvgpFT----GLwqthqG 328
Cdd:cd16031  224 GRFDTpeKYQRYMKDYLRTVTGVDDNVGRILDYLEEQGLaDNTIIIYTSDNG--------------FFlgehGL-----F 284
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115503411 329 GspaKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPqdRHFDGLDASEVLFGWSQTGHRVLF 407
Cdd:cd16031  285 D---KRLMYEESIRVPLIIRDPRLIKAGTVVDALVLNIDFAPTILDLAGVPIP--EDMQGRSLLPLLEGEKPVDWRKEF 358
sulfatase_like cd16149
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
36-384 4.19e-42

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293768 [Multi-domain]  Cd Length: 257  Bit Score: 151.24  E-value: 4.19e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGV-----THNFAVTS 110
Cdd:cd16149    1 PNILFILTDDQGPWALGCYGNSEAVTPNLDRLAAEGVRFENFFCTSPVCSPARASLLTGRMPSQHGIhdwivEGSHGKTK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 111 VG-GLPLNETTLAEVLQQAGYVTGMIGKWHLGhhgpyhpnfrgfdyyfgipyshdmgctdtpgynhppcpacprgdrpsr 189
Cdd:cd16149   81 KPeGYLEGQTTLPEVLQDAGYRCGLSGKWHLG------------------------------------------------ 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 190 slerdcytdvalplyenlniveqpvnlsslahkyaEKAIQFIQHASASGRPFLLYMGLAHMHVPISrtqlsavlrgrrpY 269
Cdd:cd16149  113 -----------------------------------DDAADFLRRRAEAEKPFFLSVNYTAPHSPWG-------------Y 144
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 270 GAGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGpwaqkcelagsvgpFT----GLWQTHQGGSPakQTTWEGGHRVP 344
Cdd:cd16149  145 FAAVTGVDRNVGRLLDELEELGlTENTLVIFTSDNG--------------FNmghhGIWGKGNGTFP--LNMYDNSVKVP 208
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 115503411 345 ALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDR 384
Cdd:cd16149  209 FIIRWPGVVPAGRVVDSLVSAYDFFPTLLELAGVDPPADP 248
sulfatase_like cd16154
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
36-404 7.87e-40

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293773 [Multi-domain]  Cd Length: 372  Bit Score: 148.27  E-value: 7.87e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWgDLGANWAETKD---TANLDKMAAEGMRFVDFHAAaSTCSPSRASLLTGRLGLRNGVThnfavtSVG 112
Cdd:cd16154    1 PNILLIIADDQGL-DSSAQYSLSSDlpvTPTLDSLANSGIVFDNLWAT-PACSPTRATILTGKYGFRTGVL------AVP 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 113 G-LPLNETTL--AEVLQQ--AGYVTGMIGKWHLGHHGPYHPNFRGFDYYFGIpyshdmgctdTPGynhppcpacprgdrp 187
Cdd:cd16154   73 DeLLLSEETLlqLLIKDAttAGYSSAVIGKWHLGGNDNSPNNPGGIPYYAGI----------LGG--------------- 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 188 srslerdcytdvALPLYENLNIVEQPVNLSSlaHKYA-----EKAIQFIQHASasgRPFLLYMGLAHMHVPI-------- 254
Cdd:cd16154  128 ------------GVQDYYNWNLTNNGQTTNS--TEYAttkltNLAIDWIDQQT---KPWFLWLAYNAPHTPFhlppaelh 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 255 SRT---QLSAVLRGRRP-YGAGLREMDSLVGQIKDKVDRTAKENTFLWFTGDNG-PwaqkcelagsvGPFTGLWQTHQGg 329
Cdd:cd16154  191 SRSllgDSADIEANPRPyYLAAIEAMDTEIGRLLASIDEEERENTIIIFIGDNGtP-----------GQVVDLPYTRNH- 258
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115503411 330 spAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQdrHFDGLDASEVLFGWSQTGHR 404
Cdd:cd16154  259 --AKGSLYEGGINVPLIVSGAGVERANERESALVNATDLYATIAELAGVDAAE--IHDSVSFKPLLSDVNASTRQ 329
G6S cd16147
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ...
35-388 1.77e-36

glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).


Pssm-ID: 293766 [Multi-domain]  Cd Length: 396  Bit Score: 139.61  E-value: 1.77e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWgDLGANWAETKdTANLdkMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvtSVGGL 114
Cdd:cd16147    1 RPNIVLILTDDQDV-ELGSMDPMPK-TKKL--LADQGTTFTNAFVTTPLCCPSRASILTGQYAHNHGVTNNSP--PGGGY 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 P------LNETTLAEVLQQAGYVTGMIGK----WHLGHHGPYHPnfRGFDYYFGIPyshdmgcTDTPGYNHppCPACPRG 184
Cdd:cd16147   75 PkfwqngLERSTLPVWLQEAGYRTAYAGKylngYGVPGGVSYVP--PGWDEWDGLV-------GNSTYYNY--TLSNGGN 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 185 DRPSRSLERDCYTDValplyenlniveqpvnlsslahkYAEKAIQFIQHASASGRPFLLYMGLAHMHVPI------SRTQ 258
Cdd:cd16147  144 GKHGVSYPGDYLTDV-----------------------IANKALDFLRRAAADDKPFFLVVAPPAPHGPFtpapryANLF 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 259 LSAVLRGRRPYG--------AGLREM-------------------------DSLVGQIKDKVDRTAK-ENTFLWFTGDNG 304
Cdd:cd16147  201 PNVTAPPRPPPNnpdvsdkpHWLRRLpplnptqiayidelyrkrlrtlqsvDDLVERLVNTLEATGQlDNTYIIYTSDNG 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 305 pwaqkcelagsvgpftglwqTHQGG---SPAKQTTWEGGHRVPALAYWPGrVPVNVTSTALLSVLDIFPTVVALAGASLP 381
Cdd:cd16147  281 --------------------YHLGQhrlPPGKRTPYEEDIRVPLLVRGPG-IPAGVTVDQLVSNIDLAPTILDLAGAPPP 339

                 ....*..
gi 115503411 382 qdRHFDG 388
Cdd:cd16147  340 --SDMDG 344
sulfatase_like cd16155
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
34-488 2.55e-34

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293774 [Multi-domain]  Cd Length: 372  Bit Score: 133.07  E-value: 2.55e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAAST----CSPSRASLLTGRlglrngvtHNFAVT 109
Cdd:cd16155    1 KKPNILFILADDQRADTIGALGNPEIQTPNLDRLARRGTSFTNAYNMGGWsgavCVPSRAMLMTGR--------TLFHAP 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 110 SVGG--LPLNETTLAEVLQQAGYVTGMIGKWHLGHHGPyhpnfrgfdyyfGIPYSHDMGCTDTP-----GYNHppcPACP 182
Cdd:cd16155   73 EGGKaaIPSDDKTWPETFKKAGYRTFATGKWHNGFADA------------AIEFLEEYKDGDKPffmyvAFTA---PHDP 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 183 RgDRPSRSLERdcYTDVALPLYENLnIVEQPVnlsslahkyaekaiqfiQHASASGRPFLLymglahmhVPISRTQlSAV 262
Cdd:cd16155  138 R-QAPPEYLDM--YPPETIPLPENF-LPQHPF-----------------DNGEGTVRDEQL--------APFPRTP-EAV 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 263 LRGRRPYGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkceLA-GSvgpfTGLwqthQGgspaKQTTWEGG 340
Cdd:cd16155  188 RQHLAEYYAMITHLDAQIGRILDALEASGElDNTIIVFTSDHG-------LAvGS----HGL----MG----KQNLYEHS 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 341 HRVPALAYWPGrVPVNVTSTALLSVLDIFPTVVALAGASLPQdrHFDGLDASEVLFGWSQTGHRVLFhpnsgaaGEFGAL 420
Cdd:cd16155  249 MRVPLIISGPG-IPKGKRRDALVYLQDVFPTLCELAGIEIPE--SVEGKSLLPVIRGEKKAVRDTLY-------GAYRDG 318
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115503411 421 Q-TVRLGSYKAFYVSGGAKacdgdvgREQhhdpplIFNLEDDVAEAVPLDrGSAEYQgvlPKVREILAD 488
Cdd:cd16155  319 QrAIRDDRWKLIIYVPGVK-------RTQ------LFDLKKDPDELNNLA-DEPEYQ---ERLKKLLAE 370
sulfatase_like cd16033
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
36-388 4.95e-34

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293757 [Multi-domain]  Cd Length: 411  Bit Score: 133.12  E-value: 4.95e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNF--AVTSVGG 113
Cdd:cd16033    1 PNILFIMTDQQRYDTLGCYGNPIVKTPNIDRLAAEGVRFTNAYTPSPVCCPARASLLTGLYPHEHGVLNNVenAGAYSRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 114 LPLNETTLAEVLQQAGYVTGMIGKWHLGHHgpYHPNFRGFDYYFgipyshdmgctdtpgynhppcpacprgdrpsrsler 193
Cdd:cd16033   81 LPPGVETFSEDLREAGYRNGYVGKWHVGPE--ETPLDYGFDEYL------------------------------------ 122
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytdvalplyenlniveqPVNlSSLAHKYAEKAIQFIQHASASGRPFLLYMGLAHMHVP-------------------- 253
Cdd:cd16033  123 -------------------PVE-TTIEYFLADRAIEMLEELAADDKPFFLRVNFWGPHDPyippepyldmydpediplpe 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 254 -----------ISR------TQLSAVLRGRRP----YGAGLREMDSLVGQIKDKVDRT-AKENTFLWFTGDNGpwaqkcE 311
Cdd:cd16033  183 sfaddfedkpyIYRrerkrwGVDTEDEEDWKEiiahYWGYITLIDDAIGRILDALEELgLADDTLVIFTSDHG------D 256
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115503411 312 LAGSvgpfTGLWQthQGGSPAKQTtweggHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDrhFDG 388
Cdd:cd16033  257 ALGA----HRLWD--KGPFMYEET-----YRIPLIIKWPGVIAAGQVVDEFVSLLDLAPTILDLAGVDVPPK--VDG 320
Sulfatase_C pfam14707
C-terminal region of aryl-sulfatase;
402-522 2.07e-33

C-terminal region of aryl-sulfatase;


Pssm-ID: 405407 [Multi-domain]  Cd Length: 122  Bit Score: 123.19  E-value: 2.07e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  402 GHRVLFHpNSGAAgefgaLQTVRLGSYKAFYV-----SGGAKACDGDVGREQHHDPPLIFNLEDDVAEAVPLDRGSAEYQ 476
Cdd:pfam14707   2 PHEFLFH-YCGAA-----LHAVRWGPYKAHFFtpsfdPPGAEGCYGSKVPVTHHDPPLLFDLERDPSEKYPLSPDSPEYP 75
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 115503411  477 GVLPKVREILADVLLDI--AGDNTSRADYTRHPSVTPCCnPHHVACRC 522
Cdd:pfam14707  76 EVLAEIKAAVEEHKATLvpVPNQLSKGNYLWDPWLQPCC-PTFPACTC 122
PRK13759 PRK13759
arylsulfatase; Provisional
31-490 1.50e-31

arylsulfatase; Provisional


Pssm-ID: 237491 [Multi-domain]  Cd Length: 485  Bit Score: 127.48  E-value: 1.50e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  31 TRGQKPNFVIILADDMGwGD-LGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLT-------GRLGLRNGV 102
Cdd:PRK13759   2 VQTKKPNIILIMVDQMR-GDcLGCNGNKAVETPNLDMLASEGYNFENAYSAVPSCTPARAALLTglsqwhhGRVGYGDVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 103 THNFavtsvgglplnETTLAEVLQQAGYVTGMIGKWHlghhgpYHP--NFRGFDYYFgipySHDmGCTDTPGYNHPPCPA 180
Cdd:PRK13759  81 PWNY-----------KNTLPQEFRDAGYYTQCIGKMH------VFPqrNLLGFHNVL----LHD-GYLHSGRNEDKSQFD 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 181 CP-------RGDRPSRSLER-----DCYTDVALP--LYENLNiveqPVNLSslahkyAEKAIQFIQHASaSGRPFLLYMG 246
Cdd:PRK13759 139 FVsdylawlREKAPGKDPDLtdigwDCNSWVARPwdLEERLH----PTNWV------GSESIEFLRRRD-PTKPFFLKMS 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 247 LAHMHVPI--------------------------------------SRTQLS--AVLRGRRPYGAGLREMDSLVGQIKDK 286
Cdd:PRK13759 208 FARPHSPYdppkryfdmykdadipdphigdweyaedqdpeggsidaLRGNLGeeYARRARAAYYGLITHIDHQIGRFLQA 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 287 V-DRTAKENTFLWFTGDNGpwaqkcELAGSvgpfTGLWQthqggspaKQTTWEGGHRVPALAYWPG---RVPVNVTSTAL 362
Cdd:PRK13759 288 LkEFGLLDNTIILFVSDHG------DMLGD----HYLFR--------KGYPYEGSAHIPFIIYDPGgllAGNRGTVIDQV 349
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 363 LSVLDIFPTVVALAGASLPQDrhFDGLDASEVLFGwSQTGHRVLFHpnsgaaGEFG----ALQTVRLGSYKAFYVSGgak 438
Cdd:PRK13759 350 VELRDIMPTLLDLAGGTIPDD--VDGRSLKNLIFG-QYEGWRPYLH------GEHAlgysSDNYLTDGKWKYIWFSQ--- 417
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 115503411 439 acdgdVGREQhhdpplIFNLEDDVAEAVPLdRGSAEYQGVLPKVREILADVL 490
Cdd:PRK13759 418 -----TGEEQ------LFDLKKDPHELHNL-SPSEKYQPRLREMRKKLVDHL 457
sulfatase_like cd16037
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
36-461 2.21e-31

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293760 [Multi-domain]  Cd Length: 321  Bit Score: 123.81  E-value: 2.21e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVtsvggLP 115
Cdd:cd16037    1 PNILIIMSDEHNPDAMGCYGHPVVRTPNLDRLAARGTRFENAYTPSPICVPSRASFLTGRYVHETGVWDNADP-----YD 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHpnfrGFDYyfgipyshdmgctdtpgynhppcpacprgdrpsrslERDC 195
Cdd:cd16037   76 GDVPSWGHALRAAGYETVLIGKLHFRGEDQRH----GFRY------------------------------------DRDV 115
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 196 ytdvalplyenlniveqpvnlsslahkyAEKAIQFIQHASASGRPFLLYMGLAHMHVP-ISRTQLSA--VLRGRRPYGAG 272
Cdd:cd16037  116 ----------------------------TEAAVDWLREEAADDKPWFLFVGFVAPHFPlIAPQEFYDlyVRRARAAYYGL 167
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 273 LREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcELAGSvgpfTGLWQthqggspaKQTTWEGGHRVPALAYWPG 351
Cdd:cd16037  168 VEFLDENIGRVLDALEELGLlDNTLIIYTSDHG------DMLGE----RGLWG--------KSTMYEESVRVPMIISGPG 229
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 352 RVPVNVTSTALlSVLDIFPTVVALAGAslPQDRHFDGLDASEVLFGWSQTGHRVL--FHPNSGAAGEFgalqTVRLGSYK 429
Cdd:cd16037  230 IPAGKRVKTPV-SLVDLAPTILEAAGA--PPPPDLDGRSLLPLAEGPDDPDRVVFseYHAHGSPSGAF----MLRKGRWK 302
                        410       420       430
                 ....*....|....*....|....*....|..
gi 115503411 430 AFYVSGgakacdgdvgreqhhDPPLIFNLEDD 461
Cdd:cd16037  303 YIYYVG---------------YPPQLFDLEND 319
choline-sulfatase cd16032
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ...
36-461 2.90e-30

choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.


Pssm-ID: 293756 [Multi-domain]  Cd Length: 327  Bit Score: 120.76  E-value: 2.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvtsvgGLP 115
Cdd:cd16032    1 PNILLIMADQLTAAALPAYGNTVVKTPNLDRLAARGVVFDNAYCNSPLCAPSRASMMTGRLPSRIGAYDNAA-----EFP 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWHLGhhGP--YHpnfrGFDYyfgipyshdmgctdtpgynhppcpacprgDRpsrsler 193
Cdd:cd16032   76 ADIPTFAHYLRAAGYRTALSGKMHFV--GPdqLH----GFDY-----------------------------DE------- 113
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 dcytDVALplyenlniveqpvnlsslahkyaeKAIQFI-QHA-SASGRPFLLYMGLAHMHVPISRTQ----LSaVLRGRR 267
Cdd:cd16032  114 ----EVAF------------------------KAVQKLyDLArGEDGRPFFLTVSFTHPHDPYVIPQeywdLY-VRRARR 164
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 268 PYGAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcELAGSvgpfTGLWQthqggspaKQTTWEGGHRVPAL 346
Cdd:cd16032  165 AYYGMVSYVDDKVGQLLDTLERTGLaDDTIVIFTSDHG------DMLGE----RGLWY--------KMSFFEGSARVPLI 226
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 347 AYWPGR-VPVNVTstALLSVLDIFPTVVALAGASLPQDR-HFDGLDASEVLFGWSQTGHRVLFHPNSGaAGEFGALQTVR 424
Cdd:cd16032  227 ISAPGRfAPRRVA--EPVSLVDLLPTLVDLAGGGTAPHVpPLDGRSLLPLLEGGDSGGEDEVISEYLA-EGAVAPCVMIR 303
                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 115503411 425 LGSYKAFYVsggakacdgdvgreqHHDPPLIFNLEDD 461
Cdd:cd16032  304 RGRWKFIYC---------------PGDPDQLFDLEAD 325
sulfatase_like cd16148
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
36-390 3.73e-29

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293767 [Multi-domain]  Cd Length: 271  Bit Score: 116.11  E-value: 3.73e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILAD----DMgwgdLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHnfavtsv 111
Cdd:cd16148    1 MNVILIVIDslraDH----LGCYGYDRVTTPNLDRLAAEGVVFDNHYSGSNPTLPSRFSLFTGLYPFYHGVWG------- 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 112 GGLPLNETTLAEVLQQAGYVTGMIGKW-HLGHHGPYHpnfRGFDYYFGIPYSHdmgctdtpgynhppcpacprGDRPSRS 190
Cdd:cd16148   70 GPLEPDDPTLAEILRKAGYYTAAVSSNpHLFGGPGFD---RGFDTFEDFRGQE--------------------GDPGEEG 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 191 LERdcytdvalplyenlniveqpvnlsslAHKYAEKAIQFIQHAsASGRPFLLYMglaHM---HVPisrtqlsavlrgrR 267
Cdd:cd16148  127 DER--------------------------AERVTDRALEWLDRN-ADDDPFFLFL---HYfdpHEP-------------Y 163
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 268 PYGAGLREMDSLVGQIKDKVDRT-AKENTFLWFTGDNGpwaqkcELAGSvgpfTGLWQTHQggspakQTTWEGGHRVPAL 346
Cdd:cd16148  164 LYDAEVRYVDEQIGRLLDKLKELgLLEDTLVIVTSDHG------EEFGE----HGLYWGHG------SNLYDEQLHVPLI 227
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 115503411 347 AYWPGRVPVNVTStALLSVLDIFPTVVALAGASLPQDrhFDGLD 390
Cdd:cd16148  228 IRWPGKEPGKRVD-ALVSHIDIAPTLLDLLGVEPPDY--SDGRS 268
iduronate-2-sulfatase cd16030
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ...
34-388 1.78e-27

iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.


Pssm-ID: 293754 [Multi-domain]  Cd Length: 435  Bit Score: 114.98  E-value: 1.78e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  34 QKPNFVIILADDM----GWgdLGANWAETkdtANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVtHNFAVT 109
Cdd:cd16030    1 KKPNVLFIAVDDLrpwlGC--YGGHPAKT---PNIDRLAARGVLFTNAYCQQPVCGPSRASLLTGRRPDTTGV-YDNNSY 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 110 SVGGLPlNETTLAEVLQQAGYVTGMIGKwhlghhgPYHPNFRGFDYYfgiPYSHDMGCTDTPGYNHPPCPACPRGDRPSr 189
Cdd:cd16030   75 FRKVAP-DAVTLPQYFKENGYTTAGVGK-------IFHPGIPDGDDD---PASWDEPPNPPGPEKYPPGKLCPGKKGGK- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 190 slerdcyTDVALPLYENLNIVEqpvnlSSLA-HKYAEKAIQFIQHASASGRPFLLYMGLAHMHVP--------------- 253
Cdd:cd16030  143 -------GGGGGPAWEAADVPD-----EAYPdGKVADEAIEQLRKLKDSDKPFFLAVGFYKPHLPfvapkkyfdlyples 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 254 ------ISRTQLSAVLRGR----RPYGAGLRE---------------------------MDSLVGQIKDKVDRTA-KENT 295
Cdd:cd16030  211 iplpnpFDPIDLPEVAWNDlddlPKYGDIPALnpgdpkgplpdeqarelrqayyasvsyVDAQVGRVLDALEELGlADNT 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 296 FLWFTGDNGpWaqkcelagSVGPfTGLWqthqggspAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVAL 375
Cdd:cd16030  291 IVVLWSDHG-W--------HLGE-HGHW--------GKHTLFEEATRVPLIIRAPGVTKPGKVTDALVELVDIYPTLAEL 352
                        410
                 ....*....|...
gi 115503411 376 AGasLPQDRHFDG 388
Cdd:cd16030  353 AG--LPAPPCLEG 363
sulfatase_like cd16035
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
36-384 1.77e-26

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293759 [Multi-domain]  Cd Length: 311  Bit Score: 109.60  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDM-GWGDLGANWAETKDTAnLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGGL 114
Cdd:cd16035    1 PNILLILTDQErYPPPWPAGWAALNLPA-RERLAANGLSFENHYTAACMCSPSRSTLYTGLHPQQTGVTDTLGSPMQPLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 PLNETTLAEVLQQAGYVTGMIGKWHLGHHGpyhpnfRGfdyyfgipyshdmgctdtpGYNHPPcpacprgdrpsrslerd 194
Cdd:cd16035   80 SPDVPTLGHMLRAAGYYTAYKGKWHLSGAA------GG-------------------GYKRDP----------------- 117
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 195 cytdvalplyenlniveqpvnlsslahKYAEKAIQFIQHASAS---GRPFLLYMGLAHMH-VPISRTQLSAVLRGRRPYG 270
Cdd:cd16035  118 ---------------------------GIAAQAVEWLRERGAKnadGKPWFLVVSLVNPHdIMFPPDDEERWRRFRNFYY 170
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 271 AGLREMDSLVGQIKDKVDRTA-KENTFLWFTGDNGpwaqkcELAGSVGpftGLwqtHQGGSPAKQTTwegghRVPALAYW 349
Cdd:cd16035  171 NLIRDVDRQIGRVLDALDASGlADNTIVVFTSDHG------EMGGAHG---LR---GKGFNAYEEAL-----HVPLIISH 233
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 115503411 350 PGRVPVNVTSTALLSVLDIFPTVVALAGASLPQDR 384
Cdd:cd16035  234 PDLFGTGQTTDALTSHIDLLPTLLGLAGVDAEARA 268
sulfatase_like cd16153
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
35-390 1.82e-26

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293772 [Multi-domain]  Cd Length: 282  Bit Score: 109.00  E-value: 1.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGA-NWAETKD---------TANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTH 104
Cdd:cd16153    1 KPNILWIITDDQRVDSLSCyNNAHTGKsesrlgyveSPNIDALAAEGVLFTNAYCNSPVCVPSRTSMLTGRYPHRTGVYG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 105 NFAVTSVGGLPLneTTLAEVLQQAGYVTGMIGKwhlGHHGPYhpnfrgfdyyfgipyshdmgcTDtpgynhppcpacprg 184
Cdd:cd16153   81 FEAAHPALDHGL--PTFPEVLKKAGYQTASFGK---SHLEAF---------------------QR--------------- 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 185 drpsrslerdcYTDVALPLYEnlniveqpvnlsSLAHKYAEKAiqfiqhasASGRPFLLYMGLAHMHVPIsrtQLSAVLR 264
Cdd:cd16153  120 -----------YLKNANQSYK------------SFWGKIAKGA--------DSDKPFFVRLSFLQPHTPV---LPPKEFR 165
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 265 GRRPYGAGLREMDSLVGQIKDKVDR----TAKENTFLWFTGDNGpwaqkcelagsvgpftglWQTHQGGSPAKQTTWEGG 340
Cdd:cd16153  166 DRFDYYAFCAYGDAQVGRAVEAFKAyslkQDRDYTIVYVTGDHG------------------WHLGEQGILAKFTFWPQS 227
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 115503411 341 HRVPALAYWPGR--VPVNVTSTALLSVLDIFPTVVALAGASLPQDRHFDGLD 390
Cdd:cd16153  228 HRVPLIVVSSDKlkAPAGKVRHDFVEFVDLAPTLLAAAGVDVDAPDYLDGRD 279
ALP_like cd00016
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ...
36-376 1.01e-24

alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.


Pssm-ID: 293732 [Multi-domain]  Cd Length: 237  Bit Score: 102.88  E-value: 1.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCS-PSRASLLTGRLGLRNGVTHNFAVT----- 109
Cdd:cd00016    1 KHVVLIVLDGLGADDLGKAGNPAPTTPNLKRLASEGATFNFRSVSPPTSSaPNHAALLTGAYPTLHGYTGNGSADpelps 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 110 SVGGLPLNETTLAEVLQQAGYVTGMIGkwhlghhgpyhpnfrgfdyyfgipyshdmgctdtpgynhppcpacprgdrpsr 189
Cdd:cd00016   81 RAAGKDEDGPTIPELLKQAGYRTGVIG----------------------------------------------------- 107
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 190 slerdcytdvalplyenlniveqpvnlsslahkyAEKAIQFIqhasASGRPFLLYMGLAHMHVPisrtqLSAVLRGRRPY 269
Cdd:cd00016  108 ----------------------------------LLKAIDET----SKEKPFVLFLHFDGPDGP-----GHAYGPNTPEY 144
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 270 GAGLREMDSLVGQIKDKVDRTAK-ENTFLWFTGDNGpwaqkcelagsvGPFTGLwqTHQGGSPAKQTTWEGGHRVPALAY 348
Cdd:cd00016  145 YDAVEEIDERIGKVLDALKKAGDaDDTVIIVTADHG------------GIDKGH--GGDPKADGKADKSHTGMRVPFIAY 210
                        330       340
                 ....*....|....*....|....*...
gi 115503411 349 WPGrVPVNVTSTALLSVLDIFPTVVALA 376
Cdd:cd00016  211 GPG-VKKGGVKHELISQYDIAPTLADLL 237
sulfatase_like cd16152
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
35-140 1.06e-20

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293771 [Multi-domain]  Cd Length: 373  Bit Score: 93.83  E-value: 1.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  35 KPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNfavtsVGGL 114
Cdd:cd16152    1 KPNVIVFFTDQQRWDTLGCYGQPLDLTPNLDALAEEGVLFENAFTPQPVCGPARACLQTGLYPTETGCFRN-----GIPL 75
                         90       100
                 ....*....|....*....|....*.
gi 115503411 115 PLNETTLAEVLQQAGYVTGMIGKWHL 140
Cdd:cd16152   76 PADEKTLAHYFRDAGYETGYVGKWHL 101
sulfatase_like cd16156
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ...
36-429 1.33e-18

uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293775 [Multi-domain]  Cd Length: 468  Bit Score: 88.59  E-value: 1.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNG-VTHNFAVTSvggl 114
Cdd:cd16156    1 KQFIFIMTDTQRWDMVGCYGNKAMKTPNLDRLAAEGVRFDSAYTTQPVCGPARSGLFTGLYPHTNGsWTNCMALGD---- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 115 plNETTLAEVLQQAGYVTGMIGKWHLGhhgpyhpnfrGFDYY-FGIpyshdmgctdtpgynhppcpaCPRGDRPSRSLER 193
Cdd:cd16156   77 --NVKTIGQRLSDNGIHTAYIGKWHLD----------GGDYFgNGI---------------------CPQGWDPDYWYDM 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 DCYTD-----------VALPLYENLNIVEQpvnlSSLAHKYAEKAIQFI-QHASasgRPFLL------------------ 243
Cdd:cd16156  124 RNYLDelteeerrksrRGLTSLEAEGIKEE----FTYGHRCTNRALDFIeKHKD---EDFFLvvsydephhpflcpkpya 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 244 --------------YMGLAH---MHVPISRTQLSAV---LRGRRPYGAGLRE-MDSLVGQIKDKVDRTAkENTFLWFTGD 302
Cdd:cd16156  197 smykdfefpkgenaYDDLENkplHQRLWAGAKPHEDgdkGTIKHPLYFGCNSfVDYEIGRVLDAADEIA-EDAWVIYTSD 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 303 NGpwaqkcELAGSvgpfTGLWqthqGGSPAkqtTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAGasLPQ 382
Cdd:cd16156  276 HG------DMLGA----HKLW----AKGPA---VYDEITNIPLIIRGKGGEKAGTVTDTPVSHIDLAPTILDYAG--IPQ 336
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 115503411 383 DRHFDGLDASEVLFGWSQTGHRVLF---------HPNsgaageFGALQTVRL---GSYK 429
Cdd:cd16156  337 PKVLEGESILATIEDPEIPENRGVFvefgryevdHDG------FGGFQPVRCvvdGRYK 389
PMH cd16028
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ...
36-488 2.04e-17

Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.


Pssm-ID: 293752 [Multi-domain]  Cd Length: 449  Bit Score: 84.62  E-value: 2.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAvtsvgGLP 115
Cdd:cd16028    1 RNVLFITADQWRADCLSCLGHPLVKTPNLDRLAAEGVRFRNHYTQAAPCGPSRASLYTGRYLMNHRSVWNGT-----PLD 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGKWH----LGHHGPYHPNFR-------GFDYYF---GIPYSH-------DMGCTDTPGYN 174
Cdd:cd16028   76 ARHLTLALELRKAGYDPALFGYTDtspdPRGLAPLDPRLLsyelampGFDPVDrldEYPAEDsdtafltDRAIEYLDERQ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 175 -------------HPP--CPAcprgdrPSRSLerdcYTDVALPLyenlniveqPVNLSSLAhkyAEKAiqfiQHasasgr 239
Cdd:cd16028  156 depwflhlsyirpHPPfvAPA------PYHAL----YDPADVPP---------PIRAESLA---AEAA----QH------ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 240 PFLLYM------GLAHMHVPISRTQLSAVLRGRRPYGAGL-REMDSLVGQIKDKVDRTAKE-NTFLWFTGDNGpwaqkcE 311
Cdd:cd16028  204 PLLAAFleriesLSFSPGAANAADLDDEEVAQMRATYLGLiAEVDDHLGRLFDYLKETGQWdDTLIVFTSDHG------E 277
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 312 LAGsvgpftglwQTHQGGspaKQTTWEGGHRVPALAYWPGRvPVNVTS----TALLSVLDIFPTVVALAGasLPQDRHFD 387
Cdd:cd16028  278 QLG---------DHWLWG---KDGFFDQAYRVPLIVRDPRR-EADATRgqvvDAFTESVDVMPTILDWLG--GEIPHQCD 342
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 388 GLD-------------ASEVLFGW-----SQTGHRVLFHPNSGAAGefgaLQTVRLGSYKafYVsggakacdgdvgreqH 449
Cdd:cd16028  343 GRSllpllagaqpsdwRDAVHYEYdfrdvSTRRPQEALGLSPDECS----LAVIRDERWK--YV---------------H 401
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 115503411 450 HD--PPLIFNLEDDVAEAVplDRGS-AEYQGVLPKVREILAD 488
Cdd:cd16028  402 FAalPPLLFDLKNDPGELR--DLAAdPAYAAVVLRYAQKLLS 441
sulfatase_like cd16150
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
36-386 2.07e-17

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293769 [Multi-domain]  Cd Length: 423  Bit Score: 84.59  E-value: 2.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGR----LGLRNgvTHNFavtsv 111
Cdd:cd16150    1 PNIVIFVADQLRADSLGHLGNPAAVTPNLDALAAEGVRFSNAYCQNPVCSPSRCSFLTGWyphvNGHRT--LHHL----- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 112 ggLPLNETTLAEVLQQAGYVTGMIGKWHlghhgpyhpnfrgfdyyfgipyshdmgctDTPGynhppcpacprgdrpSRSL 191
Cdd:cd16150   74 --LRPDEPNLLKTLKDAGYHVAWAGKND-----------------------------DLPG---------------EFAA 107
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 192 ERDCYTDVAlplyenlniveqpvnlsslahkYAEKAIQFIQHASAsGRPFLLYMGLAHMHVP----------ISRTQL-- 259
Cdd:cd16150  108 EAYCDSDEA----------------------CVRTAIDWLRNRRP-DKPFCLYLPLIFPHPPygveepwfsmIDREKLpp 164
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 260 -----------SAVLRGRRPYG------AGLREM-----------DSLVGQIKDKVDRTA-KENTFLWFTGDNGPWAqkc 310
Cdd:cd16150  165 rrppglrakgkPSMLEGIEKQGldrwseERWRELratylgmvsrlDHQFGRLLEALKETGlYDDTAVFFFSDHGDYT--- 241
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115503411 311 elagsvGPFtGLWQTHQGGSPAKQTtwegghRVPALAYWPGRVPVNVTStALLSVLDIFPTVVALAGASLPQDrHF 386
Cdd:cd16150  242 ------GDY-GLVEKWPNTFEDCLT------RVPLIIKPPGGPAGGVSD-ALVELVDIPPTLLDLAGIPLSHT-HF 302
ARSK cd16171
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ...
36-382 6.78e-16

arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293781 [Multi-domain]  Cd Length: 366  Bit Score: 79.51  E-value: 6.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  36 PNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGrlgLRNGVTHNFavTSVGGLP 115
Cdd:cd16171    1 PNVVMVMSDSFDGRLTFRPGNQVVDLPYINFMKQHGSVFLNAYTNSPICCPSRAAMWSG---LFTHLTESW--NNYKGLD 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 116 LNETTLAEVLQQAGYVTGMIGK--WHLGHHGPYHpnfRGFDYYFGIPYshdmgctdTPGYNHPPCPACPRGDRPSRSLER 193
Cdd:cd16171   76 PNYPTWMDRLEKHGYHTQKYGKldYTSGHHSVSN---RVEAWTRDVPF--------LLRQEGRPTVNLVGDRSTVRVMLK 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 194 DCytdvalplyenlniveqpvnlsslahKYAEKAIQFIQHASAS-GRPFLLYMGLAHMH---VPISRTQLSAVLRGRRPY 269
Cdd:cd16171  145 DW--------------------------QNTDKAVHWIRKEAPNlTQPFALYLGLNLPHpypSPSMGENFGSIRNIRAFY 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 270 GAGLREMDSLVGQIKDKVDRTAKEN-TFLWFTGDNGpwaqkcELAGSVGPFTglwqthqggspaKQTTWEGGHRVPALAY 348
Cdd:cd16171  199 YAMCAETDAMLGEIISALKDTGLLDkTYVFFTSDHG------ELAMEHRQFY------------KMSMYEGSSHVPLLIM 260
                        330       340       350
                 ....*....|....*....|....*....|....
gi 115503411 349 WPGrVPVNVTSTALLSVLDIFPTVVALAGASLPQ 382
Cdd:cd16171  261 GPG-IKAGQQVSDVVSLVDIYPTMLDIAGVPQPQ 293
MdoB COG1368
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ...
27-386 1.03e-06

Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440979 [Multi-domain]  Cd Length: 576  Bit Score: 51.58  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  27 PSGETRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMAAEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVthnf 106
Cdd:COG1368  226 PNPFGPAKKPNVVVILLESFSDFFIGALGNGKDVTPFLDSLAKESLYFGNFYSQGGRTSRGEFAVLTGLPPLPGGS---- 301
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 107 AVTSVGGLPLNetTLAEVLQQAGYVTGMIgkwhlghHGpYHPNFR---------GFDYYFGI-----PYSHDMGCTDTPG 172
Cdd:COG1368  302 PYKRPGQNNFP--SLPSILKKQGYETSFF-------HG-GDGSFWnrdsfyknlGFDEFYDRedfddPFDGGWGVSDEDL 371
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 173 YNHppcpacprgdrpsrslerdcytdvalpLYENLNIVEQP-----VNLSSlaHkyaekaiqfiqhasasgRPFLLYMGL 247
Cdd:COG1368  372 FDK---------------------------ALEELEKLKKPffaflITLSN--H-----------------GPYTLPEED 405
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411 248 AHMhVPISRTQLSAVLrgrrpygAGLREMDSLVGQIKDKVD-RTAKENTFLWFTGDngpwaqkcelagsvgpftglwqtH 326
Cdd:COG1368  406 KKI-PDYGKTTLNNYL-------NAVRYADQALGEFIEKLKkSGWYDNTIFVIYGD-----------------------H 454
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115503411 327 QGGSPAKQTTWE--GGHRVPALAYWPGRVPVNVTSTaLLSVLDIFPTVVALAGASLPQDRHF 386
Cdd:COG1368  455 GPRSPGKTDYENplERYRVPLLIYSPGLKKPKVIDT-VGSQIDIAPTLLDLLGIDYPSYYAF 515
AtaC COG1524
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ...
14-162 4.49e-04

c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];


Pssm-ID: 441133 [Multi-domain]  Cd Length: 370  Bit Score: 42.81  E-value: 4.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  14 TFLGCLYPLVDFCPSGeTRGQKPNFVIILADDMGWGDLGANwaetkDTANLDKMAAEGMRFVDFHAA--ASTCsPSRASL 91
Cdd:COG1524    3 RGLSLLLASLLAAAAA-AAPPAKKVVLILVDGLRADLLERA-----HAPNLAALAARGVYARPLTSVfpSTTA-PAHTTL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115503411  92 LTGRLGLRNGVTHNF--------AVTSVGGLP--------LNETTLAEVLQQAGYVTGMIGKWHLGHHGPYHPN----FR 151
Cdd:COG1524   76 LTGLYPGEHGIVGNGwydpelgrVVNSLSWVEdgfgsnslLPVPTIFERARAAGLTTAAVFWPSFEGSGLIDAArpypYD 155
                        170
                 ....*....|.
gi 115503411 152 GFDYYFGIPYS 162
Cdd:COG1524  156 GRKPLLGNPAA 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH