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Chain D, SKP1
SKP1 family protein( domain architecture ID 13034557)
SKP1 family protein may be a component of E3 ubiquitin ligase SCF complex involved in ubiquitination and subsequent proteasomal degradation of target proteins; similar to Homo sapiens S-phase kinase-associated protein 1 (SKP1)
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
BTB_POZ_SKP1 | cd18322 | BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ... |
4-113 | 2.24e-69 | |||
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids. : Pssm-ID: 349631 Cd Length: 120 Bit Score: 204.75 E-value: 2.24e-69
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Skp1 | pfam01466 | Skp1 family, dimerization domain; |
99-146 | 7.32e-29 | |||
Skp1 family, dimerization domain; : Pssm-ID: 460222 Cd Length: 48 Bit Score: 99.88 E-value: 7.32e-29
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Name | Accession | Description | Interval | E-value | |||
BTB_POZ_SKP1 | cd18322 | BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ... |
4-113 | 2.24e-69 | |||
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349631 Cd Length: 120 Bit Score: 204.75 E-value: 2.24e-69
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SKP1 | COG5201 | SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ... |
1-149 | 1.06e-56 | |||
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 227528 [Multi-domain] Cd Length: 158 Bit Score: 174.36 E-value: 1.06e-56
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Skp1 | smart00512 | Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ... |
1-98 | 5.33e-46 | |||
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues. Pssm-ID: 214704 Cd Length: 104 Bit Score: 145.13 E-value: 5.33e-46
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Skp1 | pfam01466 | Skp1 family, dimerization domain; |
99-146 | 7.32e-29 | |||
Skp1 family, dimerization domain; Pssm-ID: 460222 Cd Length: 48 Bit Score: 99.88 E-value: 7.32e-29
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Skp1_POZ | pfam03931 | Skp1 family, tetramerization domain; |
2-61 | 2.71e-28 | |||
Skp1 family, tetramerization domain; Pssm-ID: 397838 Cd Length: 60 Bit Score: 98.91 E-value: 2.71e-28
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Name | Accession | Description | Interval | E-value | |||
BTB_POZ_SKP1 | cd18322 | BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ... |
4-113 | 2.24e-69 | |||
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349631 Cd Length: 120 Bit Score: 204.75 E-value: 2.24e-69
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SKP1 | COG5201 | SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ... |
1-149 | 1.06e-56 | |||
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 227528 [Multi-domain] Cd Length: 158 Bit Score: 174.36 E-value: 1.06e-56
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Skp1 | smart00512 | Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ... |
1-98 | 5.33e-46 | |||
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues. Pssm-ID: 214704 Cd Length: 104 Bit Score: 145.13 E-value: 5.33e-46
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Skp1 | pfam01466 | Skp1 family, dimerization domain; |
99-146 | 7.32e-29 | |||
Skp1 family, dimerization domain; Pssm-ID: 460222 Cd Length: 48 Bit Score: 99.88 E-value: 7.32e-29
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Skp1_POZ | pfam03931 | Skp1 family, tetramerization domain; |
2-61 | 2.71e-28 | |||
Skp1 family, tetramerization domain; Pssm-ID: 397838 Cd Length: 60 Bit Score: 98.91 E-value: 2.71e-28
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BTB_POZ_EloC | cd18321 | BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ... |
4-98 | 5.63e-16 | |||
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids. Pssm-ID: 349630 Cd Length: 95 Bit Score: 68.38 E-value: 5.63e-16
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BTB_POZ | cd01165 | BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ... |
9-96 | 1.21e-11 | |||
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain. Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 56.91 E-value: 1.21e-11
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Blast search parameters | ||||
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