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Conserved domains on  [gi|1151112976|ref|WP_078085268|]
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LytTR family DNA-binding domain-containing protein [Microbulbifer mangrovi]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-266 3.51e-89

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 264.37  E-value: 3.51e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK-DEMPQIVFV 84
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRElDPPPPIIFT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  85 TAYDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKLGSENLAAQREQlleavadltqespeslevklaagelggsrF 164
Cdd:COG3279    82 TAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPE-----------------------------E 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976 165 PEKIAIKDSGKITLVPAREIDWIDAAGDYMCVHANGETHVMRITMKELEQQLDPKVFQRIHRSTIVNLKRVREICAHING 244
Cdd:COG3279   133 KDRIFVKSGGKLVKIPLDDILYIEAEGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNG 212

                         250       260
                  ....*....|....*....|..
gi 1151112976 245 EyhLVLNNGERLKMSRSYKNKV 266
Cdd:COG3279   213 E--VVLKNGEEIPVSRRYKKEF 232
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-266 3.51e-89

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 264.37  E-value: 3.51e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK-DEMPQIVFV 84
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRElDPPPPIIFT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  85 TAYDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKLGSENLAAQREQlleavadltqespeslevklaagelggsrF 164
Cdd:COG3279    82 TAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPE-----------------------------E 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976 165 PEKIAIKDSGKITLVPAREIDWIDAAGDYMCVHANGETHVMRITMKELEQQLDPKVFQRIHRSTIVNLKRVREICAHING 244
Cdd:COG3279   133 KDRIFVKSGGKLVKIPLDDILYIEAEGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNG 212

                         250       260
                  ....*....|....*....|..
gi 1151112976 245 EyhLVLNNGERLKMSRSYKNKV 266
Cdd:COG3279   213 E--VVLKNGEEIPVSRRYKKEF 232
PRK11697 PRK11697
two-component system response regulator BtsR;
6-262 1.06e-58

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 186.59  E-value: 1.06e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVT 85
Cdd:PRK11697    2 IKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLDPEHMPYIVFVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  86 AYDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREklgseNLAAQREQLLEAVADLTQeSPESlevklaagelGGSRfp 165
Cdd:PRK11697   82 AFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQ-----ERSPQDVLLPEAQPPLKH-IPCT----------GHNR-- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976 166 ekiaikdsgkITLVPAREIDWI--DAAGDYmcVHANGETHVMRITMKELEQQLDpkvFQRIHRSTIVNLKRVREICAHIN 243
Cdd:PRK11697  144 ----------IKLLPLEEVEFVssRLSGVH--VVSAEGKGFTELTLKTLEEKTP---LLRCHRQYLVNPAAIQEIRLLDN 208

                         250
                  ....*....|....*....
gi 1151112976 244 GEYHLVLNNGERLKMSRSY 262
Cdd:PRK11697  209 GQAEIITRSGHTVPVSRRY 227
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 8-124 4.22e-49

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 158.08  E-value: 4.22e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK-DEMPQIVFVTA 86
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKlAKPPLIVFVTA 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1151112976  87 YDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKLG 124
Cdd:cd17532    81 YDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 174-267 1.03e-32

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 115.37  E-value: 1.03e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  174 GKITLVPAREIDWIDAAGDYMCVHANGETHVMRITMKELEQQLDPKVFQRIHRSTIVNLKRVREICAHINGEYHLVLNNG 253
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILKNG 80

                           90
                   ....*....|....
gi 1151112976  254 ERLKMSRSYKNKVQ 267
Cdd:smart00850  81 EEVPVSRRYLKELK 94
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 174-266 6.03e-27

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 100.36  E-value: 6.03e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976 174 GKITLVPAREIDWIDAAGDYMCVHANGETHVMRITMKELEQQLDPKVFQRIHRSTIVNLKRVREICAHINGEYHLVLNNG 253
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDKYVTIHTANGEYLTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDFNGTYELTLKNG 80

                          90
                  ....*....|...
gi 1151112976 254 ERLKMSRSYKNKV 266
Cdd:pfam04397  81 EKIPVSRRYLKEL 93
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 4-156 3.67e-10

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 59.04  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   4 DSLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMP---GVTGLELVQLLPKDEMPQ 80
Cdd:TIGR02875   1 HKIRIVIADDNKEFCNLLKEYLAAQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPhldGIGVLEKLNEIELSARPR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1151112976  81 IVFVTAYDQYAV--EAFEVNAVDYVLKPIEedrlsramqrvreklgSENLAAQREQLLE-AVADLTQESPESLEVKLAA 156
Cdd:TIGR02875  81 VIMLSAFGQEKItqRAVALGADYYVLKPFD----------------LEILAARIRQLAWgTNADILADSPTVPPASHAA 143
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-266 3.51e-89

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 264.37  E-value: 3.51e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK-DEMPQIVFV 84
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRElDPPPPIIFT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  85 TAYDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKLGSENLAAQREQlleavadltqespeslevklaagelggsrF 164
Cdd:COG3279    82 TAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPE-----------------------------E 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976 165 PEKIAIKDSGKITLVPAREIDWIDAAGDYMCVHANGETHVMRITMKELEQQLDPKVFQRIHRSTIVNLKRVREICAHING 244
Cdd:COG3279   133 KDRIFVKSGGKLVKIPLDDILYIEAEGNYVKIHTKDKKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNG 212

                         250       260
                  ....*....|....*....|..
gi 1151112976 245 EyhLVLNNGERLKMSRSYKNKV 266
Cdd:COG3279   213 E--VVLKNGEEIPVSRRYKKEF 232
PRK11697 PRK11697
two-component system response regulator BtsR;
6-262 1.06e-58

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 186.59  E-value: 1.06e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVT 85
Cdd:PRK11697    2 IKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLDPEHMPYIVFVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  86 AYDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREklgseNLAAQREQLLEAVADLTQeSPESlevklaagelGGSRfp 165
Cdd:PRK11697   82 AFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQ-----ERSPQDVLLPEAQPPLKH-IPCT----------GHNR-- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976 166 ekiaikdsgkITLVPAREIDWI--DAAGDYmcVHANGETHVMRITMKELEQQLDpkvFQRIHRSTIVNLKRVREICAHIN 243
Cdd:PRK11697  144 ----------IKLLPLEEVEFVssRLSGVH--VVSAEGKGFTELTLKTLEEKTP---LLRCHRQYLVNPAAIQEIRLLDN 208

                         250
                  ....*....|....*....
gi 1151112976 244 GEYHLVLNNGERLKMSRSY 262
Cdd:PRK11697  209 GQAEIITRSGHTVPVSRRY 227
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 8-124 4.22e-49

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 158.08  E-value: 4.22e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK-DEMPQIVFVTA 86
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKlAKPPLIVFVTA 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1151112976  87 YDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKLG 124
Cdd:cd17532    81 YDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
PRK14084 PRK14084
DNA-binding response regulator;
6-270 2.85e-34

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 124.09  E-value: 2.85e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK-DEMPQIVFV 84
Cdd:PRK14084    1 MKALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKmKEPPAIIFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  85 TAYDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKLGSENLAAQrEQLLEAVADLTQESPesLEVKlaagelggsrf 164
Cdd:PRK14084   81 TAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRATKAKDDNNAS-AIANDMSANFDQSLP--IEID----------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976 165 pEKIAIKDSGKITLVPARE-IDWIDAagdymcVHANGETHVmriTMKELEQQLDPKVFQRIHRSTIVNLKRVREICAHIN 243
Cdd:PRK14084  147 -DKIHMLNQQDIIAIGVHNgITTIHT------TNHKYETTE---PLNRYEKRLNPTYFIRIHRSYIINKKHIKEVEQWFN 216

                         250       260
                  ....*....|....*....|....*..
gi 1151112976 244 GEYHLVLNNGERLKMSRSYKNKVQHFI 270
Cdd:PRK14084  217 YTYQVILTNGVKMQVSRSFMKDFKASI 243
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 174-267 1.03e-32

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 115.37  E-value: 1.03e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  174 GKITLVPAREIDWIDAAGDYMCVHANGETHVMRITMKELEQQLDPKVFQRIHRSTIVNLKRVREICAHINGEYHLVLNNG 253
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILKNG 80

                           90
                   ....*....|....
gi 1151112976  254 ERLKMSRSYKNKVQ 267
Cdd:smart00850  81 EEVPVSRRYLKELK 94
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 8-123 2.10e-32

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 115.13  E-value: 2.10e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARR--GLRLRLENLGgVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMP--QIVF 83
Cdd:cd17536     1 VLIVDDEPLIREglKKLIDWEELG-FEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKI-RELYPdiKIII 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1151112976  84 VTAYD--QYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKL 123
Cdd:cd17536    79 LSGYDdfEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEEL 120
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 174-266 6.03e-27

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 100.36  E-value: 6.03e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976 174 GKITLVPAREIDWIDAAGDYMCVHANGETHVMRITMKELEQQLDPKVFQRIHRSTIVNLKRVREICAHINGEYHLVLNNG 253
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDKYVTIHTANGEYLTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDFNGTYELTLKNG 80

                          90
                  ....*....|...
gi 1151112976 254 ERLKMSRSYKNKV 266
Cdd:pfam04397  81 EKIPVSRRYLKEL 93
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 7-106 1.83e-26

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 99.08  E-value: 1.83e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQ--IVFV 84
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAI-RELDPDtkIIIL 79

                          90       100
                  ....*....|....*....|....
gi 1151112976  85 TAYDQ--YAVEAFEVNAVDYVLKP 106
Cdd:COG4753    80 SGYSDfeYAQEAIKLGADDYLLKP 103
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 4-138 1.49e-25

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 98.12  E-value: 1.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   4 DSLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQ--I 81
Cdd:COG4565     2 KMIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLREL-RARGPDvdV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1151112976  82 VFVTAYDQYAV--EAFEVNAVDYVLKPIEEDRLSRAMQRVREKLgSENLAAQREQLLEA 138
Cdd:COG4565    81 IVITAARDPETvrEALRAGVVDYLIKPFTFERLREALERYLEYR-RLLREDQEEDLPEA 138
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 8-112 6.44e-24

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 92.98  E-value: 6.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEM-PQIVFVTA 86
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEG--YVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPtTPVIILTA 78

                          90       100
                  ....*....|....*....|....*...
gi 1151112976  87 YDQ--YAVEAFEVNAVDYVLKPIEEDRL 112
Cdd:pfam00072  79 HGDedDAVEALEAGADDFLSKPFDPDEL 106
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 8-119 8.73e-22

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 87.57  E-value: 8.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQ--IVFVT 85
Cdd:cd17535     1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRL-RRRYPDlkVIVLT 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1151112976  86 AYD--QYAVEAFEVNAVDYVLKPIEEDRLSRAMQRV 119
Cdd:cd17535    80 AHDdpEYVLRALKAGAAGYLLKDSSPEELIEAIRAV 115
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-155 1.22e-20

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 87.53  E-value: 1.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   1 MSSDS-LKVIIVDDEPLARRGLRLRLENLGgVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMP 79
Cdd:COG3437     1 MRTGQaPTVLIVDDDPENLELLRQLLRTLG-YDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPST 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  80 Q---IVFVTAYD--QYAVEAFEVNAVDYVLKPIEEDRLsraMQRVREKLgseNLAAQREQLLEAVADLTQESPESLEVKL 154
Cdd:COG3437    79 RdipVIFLTALAdpEDRERALEAGADDYLTKPFDPEEL---LARVRNAL---ELRRLQRELDDLVLYLKLAAPLHDIGKI 152


                  .
gi 1151112976 155 A 155
Cdd:COG3437   153 G 153
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-119 3.00e-20

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 83.75  E-value: 3.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   1 MSSDSLKVIIVDDEPLARRGLRLRLENLGgVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL----PKD 76
Cdd:COG0784     1 PPLGGKRILVVDDNPDNRELLRRLLERLG-YEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIralpRLP 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1151112976  77 EMPqIVFVTAYDQYAV--EAFEVNAVDYVLKPIEEDRLSRAMQRV 119
Cdd:COG0784    79 DIP-IIALTAYADEEDreRALEAGADDYLTKPVDPEELLEALRRL 122
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 5-152 1.51e-19

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 87.33  E-value: 1.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   5 SLKVIIVDDEPLARRGLRLRLENLGgVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKD--EMPqIV 82
Cdd:COG2204     2 MARILVVDDDPDIRRLLKELLERAG-YEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALdpDLP-VI 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1151112976  83 FVTAYD--QYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKlgsenlaAQREQLLEAVADLTQESPESLEV 152
Cdd:COG2204    79 LLTGYGdvETAVEAIKAGAFDYLTKPFDLEELLAAVERALER-------RRLRRENAEDSGLIGRSPAMQEV 143
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 5-112 5.80e-19

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 81.88  E-value: 5.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   5 SLKVIIVDDEPLARRGLRLRLENLGgVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL---PKDEMPQI 81
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLEAAG-YEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLradPRTADIPI 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1151112976  82 VFVTAYD--QYAVEAFEVNAVDYVLKPIEEDRL 112
Cdd:COG3706    79 IFLTALDdeEDRARALEAGADDYLTKPFDPEEL 111
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 6-120 9.32e-19

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 79.60  E-value: 9.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMP-QIVFV 84
Cdd:cd19925     1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDvDVIVV 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1151112976  85 TAYDQYAV--EAFEVNAVDYVLKPIEEDRLSRAMQRVR 120
Cdd:cd19925    81 TAANDVETvrEALRLGVVDYLIKPFTFERLRQRLERYR 118
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 10-106 1.83e-18

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 78.04  E-value: 1.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  10 IVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ-IVFVTAYD 88
Cdd:cd00156     2 IVDDDPAIRELLKSLLEREG--YEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIpVIVLTAKA 79

                          90       100
                  ....*....|....*....|
gi 1151112976  89 --QYAVEAFEVNAVDYVLKP 106
Cdd:cd00156    80 deEDAVRALELGADDYLVKP 99
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 4-144 1.04e-17

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 78.85  E-value: 1.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   4 DSLKVIIVDDEPLARRGLRLRLENLGgVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVF 83
Cdd:COG3707     2 RGLRVLVVDDEPLRRADLREGLREAG-YEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1151112976  84 VTAYDQYAV--EAFEVNAVDYVLKPIEEDRLSRAMQRVREKlgsenlAAQREQLLEAVADLTQ 144
Cdd:COG3707    81 LTAYSDPELieRALEAGVSAYLVKPLDPEDLLPALELALAR------FRELRALRRELAKLRE 137
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 7-119 3.94e-17

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 75.01  E-value: 3.94e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENlGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK-DEMPQIVFVT 85
Cdd:cd17542     2 KVLIVDDAAFMRMMLKDILTK-AGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKiDPNAKVIMCS 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1151112976  86 AYDQYA--VEAFEVNAVDYVLKPIEEDRLSRAMQRV 119
Cdd:cd17542    81 AMGQEEmvKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 7-123 4.37e-17

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 75.12  E-value: 4.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELV-QLLPKDEMPqIVFVT 85
Cdd:cd17541     2 RVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALrRIMAERPTP-VVMVS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1151112976  86 AYDQ----YAVEAFEVNAVDYVLKPieEDRLSRAMQRVREKL 123
Cdd:cd17541    81 SLTEegaeITLEALELGAVDFIAKP--SGGISLDLEEIAEEL 120
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 5-120 1.36e-16

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 76.15  E-value: 1.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   5 SLKVIIVDDEPLARRGLRLRLENLGgVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDE--MPqIV 82
Cdd:COG0745     1 MPRILVVEDDPDIRELLADALEREG-YEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPsdIP-II 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1151112976  83 FVTAYDQYA--VEAFEVNAVDYVLKPIEEDRLsraMQRVR 120
Cdd:COG0745    78 MLTARDDEEdrVRGLEAGADDYLTKPFDPEEL---LARIR 114
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 6-117 2.60e-16

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 72.83  E-value: 2.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENlGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVT 85
Cdd:cd19932     1 VRVLIAEDEALIRMDLREMLEE-AGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVLLT 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1151112976  86 AYDQ--YAVEAFEVNAVDYVLKPIEEDRLSRAMQ 117
Cdd:cd19932    80 AYSQqdLVERAKEAGAMAYLVKPFSESDLIPAIE 113
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 7-120 6.66e-16

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 71.70  E-value: 6.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVEVVAeCGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL---PKDEMPQIVF 83
Cdd:cd17551     2 RILIVDDNPTNLLLLEALLRSAGYLEVVS-FTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLralPGLEDVPIVM 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1151112976  84 VTAYDQYAV--EAFEVNAVDYVLKPIEEDRLsRAmqRVR 120
Cdd:cd17551    81 ITADTDREVrlRALEAGATDFLTKPFDPVEL-LA--RVR 116
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 7-117 1.47e-15

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 70.90  E-value: 1.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPG-VTGLELVQLLpKDEMP-QIVFV 84
Cdd:cd17534     2 KILIVEDEAIIALDLKEILESLGY-EVVGIADSGEEAIELAEENKPDLILMDINLKGdMDGIEAAREI-REKFDiPVIFL 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1151112976  85 TAY-DQYAVE-AFEVNAVDYVLKPIEEDRLSRAMQ 117
Cdd:cd17534    80 TAYsDEETLErAKETNPYGYLVKPFNERELKAAIE 114
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 8-107 1.91e-15

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 70.23  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAEcgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ---IVFV 84
Cdd:cd19920     1 ILIVDDVPDNLRLLSELLRAAGYRVLVAT--DGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKADPATRhipVIFL 78

                          90       100
                  ....*....|....*....|....*
gi 1151112976  85 TAYD--QYAVEAFEVNAVDYVLKPI 107
Cdd:cd19920    79 TALTdtEDKVKGFELGAVDYITKPF 103
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 8-121 1.79e-14

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 68.07  E-value: 1.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQ--IVFVT 85
Cdd:cd19930     1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAEL-REELPDtkVLIVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1151112976  86 -----AYDQYAVEAfevNAVDYVLKPIEEDRLSRAMQRVRE 121
Cdd:cd19930    80 tfgrpGYFRRALAA---GVDGYVLKDRPIEELADAIRTVHA 117
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 6-73 8.78e-14

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 66.45  E-value: 8.78e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL 73
Cdd:COG2197     2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
3-123 1.06e-13

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 69.79  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   3 SDSLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLE-LVQLLPKDEMPQI 81
Cdd:PRK00742    1 MMKIRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDaLEKIMRLRPTPVV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1151112976  82 VF---------VTaydqyaVEAFEVNAVDYVLKPIEedRLSRAMQRVREKL 123
Cdd:PRK00742   81 MVssltergaeIT------LRALELGAVDFVTKPFL--GISLGMDEYKEEL 123
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 3-126 1.47e-13

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 68.67  E-value: 1.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   3 SDSLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTG---LELVQLLPKDEMP 79
Cdd:COG5801     2 MEKIKVLIADDNREFCELLEEYLSSQPDMEVVGVAYNGLEALELIEEKKPDVVILDIIMPHLDGlgvLEKLREMNLEKRP 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1151112976  80 QIVFVTAYDQYAV--EAFEVNAVDYVLKPIEEDRL-SRAMQRVREKLGSE 126
Cdd:COG5801    82 KVIMLTAFGQEDItqRAVELGADYYILKPFDLDVLaERIRQLAGGKAESE 131
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 7-107 4.27e-13

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 63.67  E-value: 4.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGgVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ---IVF 83
Cdd:cd17538     1 KILVVDDEPANRELLEALLSAEG-YEVL-TADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRhipVIM 78

                          90       100
                  ....*....|....*....|....*.
gi 1151112976  84 VTAYDQYA--VEAFEVNAVDYVLKPI 107
Cdd:cd17538    79 ITALDDREdrIRGLEAGADDFLSKPI 104
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 10-106 6.16e-13

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 63.20  E-value: 6.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  10 IVDDEPLARRGLRLRLENLGGVevVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKD--EMPqIVFVTAY 87
Cdd:cd17574     2 VVEDDEEIAELLSDYLEKEGYE--VDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKgsDIP-IIMLTAK 78

                          90       100
                  ....*....|....*....|.
gi 1151112976  88 DQYA--VEAFEVNAVDYVLKP 106
Cdd:cd17574    79 DEEEdkVLGLELGADDYITKP 99
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 8-116 1.50e-12

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 62.49  E-value: 1.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGgVEVVAeCGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEM----PQIVF 83
Cdd:cd17546     1 VLVVDDNPVNRKVLKKLLEKLG-YEVDV-AENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEGggrrTPIIA 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1151112976  84 VTAYDQYAV--EAFEVNAVDYVLKPIEEDRLSRAM 116
Cdd:cd17546    79 LTANALEEDreKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 7-109 1.63e-12

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 62.60  E-value: 1.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK--DEMPQIVFV 84
Cdd:cd17555     2 TILVIDDDEVVRESIAAYLEDSG--FQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKesPDTPVIVVS 79

                          90       100
                  ....*....|....*....|....*.
gi 1151112976  85 TAYD-QYAVEAFEVNAVDYVLKPIEE 109
Cdd:cd17555    80 GAGVmSDAVEALRLGAWDYLTKPIED 105
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 1-173 2.30e-12

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 64.66  E-value: 2.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   1 MSSDSLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLE-LVQLLPKDEMP 79
Cdd:PRK10651    2 SNQEPATILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLEtLDKLREKSLSG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  80 QIVFVTAYDQYA--VEAFEVNAVDYVLKPIEEDRLSRAMQR-------VREKLGSENLAAQREQLLEAVADLTQESPESL 150
Cdd:PRK10651   82 RIVVFSVSNHEEdvVTALKRGADGYLLKDMEPEDLLKALQQaaagemvLSEALTPVLAASLRANRATTERDVNQLTPRER 161

                         170       180
                  ....*....|....*....|....
gi 1151112976 151 EV-KLAAGELGGSRFPEKIAIKDS 173
Cdd:PRK10651  162 DIlKLIAQGLPNKMIARRLDITES 185
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 6-106 5.76e-12

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 61.09  E-value: 5.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMP---GVTGLELVQLLPKDEMPQIV 82
Cdd:cd17561     2 IKVLIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPhldGIGVLEKLRRMRLEKRPKII 81

                          90       100
                  ....*....|....*....|....*.
gi 1151112976  83 FVTAYDQYAV--EAFEVNAVDYVLKP 106
Cdd:cd17561    82 MLTAFGQEDItqRAVELGASYYILKP 107
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 7-105 8.37e-12

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 60.70  E-value: 8.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVEVVAecGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL--PKDEMPqIVFV 84
Cdd:cd17554     2 KILVVDDEENIRELYKEELEDEGYEVVTA--GNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIreKKPDLP-VIIC 78

                          90       100
                  ....*....|....*....|.
gi 1151112976  85 TAYDQYAVEAFEVNAVDYVLK 105
Cdd:cd17554    79 TAYSEYKSDFSSWAADAYVVK 99
dpiA PRK10046
two-component response regulator DpiA; Provisional
 3-133 1.32e-11

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 62.73  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   3 SDSLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMP-QI 81
Cdd:PRK10046    2 TAPLTLLIVEDETPLAEMHAEYIRHIPGFSQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPgDV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1151112976  82 VFVTAYD--QYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREK---LGSENLAAQRE 133
Cdd:PRK10046   82 VFTTAASdmETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRkhmLESIDSASQKQ 138
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 2-121 1.55e-11

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 61.47  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   2 SSDSLKVIIVDDEPLARRGLRLRLENLGgVEVVAeCGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQ-LLPKDEMPQ 80
Cdd:COG4567     1 SAEDRSLLLVDDDEAFARVLARALERRG-FEVTT-AASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEaLRERDPDAR 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1151112976  81 IVFVTAY--DQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVRE 121
Cdd:COG4567    79 IVVLTGYasIATAVEAIKLGADDYLAKPADADDLLAALERAEG 121
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
7-118 5.34e-11

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 62.17  E-value: 5.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLeNLGGVEVVAeCGNGREAKEQIEQLKPDVAFLDIQMPGVTGLE-LVQLLPKDEMPQIVFVT 85
Cdd:PRK11361    6 RILIVDDEDNVRRMLSTAF-ALQGFETHC-ANNGRTALHLFADIHPDVVLMDIRMPEMDGIKaLKEMRSHETRTPVILMT 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1151112976  86 AYDQY--AVEAFEVNAVDYVLKPIEEDRLSRAMQR 118
Cdd:PRK11361   84 AYAEVetAVEALRCGAFDYVIKPFDLDELNLIVQR 118
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 34-144 6.74e-11

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 60.11  E-value: 6.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  34 VAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL--PKDEMPqIVFVTAY-D-QYAVEAFEVNAVDYVLKPIEE 109
Cdd:COG4566    26 VETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELaaRGSPLP-VIFLTGHgDvPMAVRAMKAGAVDFLEKPFDD 104

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1151112976 110 DRL----SRAMQRVREKLGSEnlaAQREQLLEAVADLTQ 144
Cdd:COG4566   105 QALldavRRALARDRARRAER---ARRAELRARLASLTP 140
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 34-112 8.48e-11

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 57.98  E-value: 8.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  34 VAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMP-QIVFVTAYD--QYAVEAFEVNAVDYVLKPIEED 110
Cdd:cd17572    25 VTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPtSVIVITAHGsvDIAVEAMRLGAYDFLEKPFDAD 104


                  ..
gi 1151112976 111 RL 112
Cdd:cd17572   105 RL 106
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 34-106 1.06e-10

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 57.67  E-value: 1.06e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1151112976  34 VAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQI--VFVTAYD--QYAVEAFEVNAVDYVLKP 106
Cdd:cd19919    27 VTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQI-KQRHPDLpvIIMTAHSdlDSAVSAYQGGAFEYLPKP 102
PRK15369 PRK15369
two component system response regulator;
5-150 1.11e-10

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 59.71  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   5 SLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELV-QLLPKDEMPQIVF 83
Cdd:PRK15369    3 NYKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIpQLHQRWPAMNILV 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  84 VTAYDQ--YAVEAFEVNAVDYVLKPIEEDRLSRAMQRVreKLGSENL-AAQREQLLEAVADLTQESPESL 150
Cdd:PRK15369   83 LTARQEehMASRTLAAGALGYVLKKSPQQILLAAIQTV--AVGKRYIdPALNREAILALLNADDTNPPLL 150
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
5-172 1.18e-10

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 59.87  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   5 SLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEM-PQIVF 83
Cdd:PRK10403    6 PFQVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVtAQIII 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  84 VT----AYDQYAVeaFEVNAVDYVLKPIEEDRLSRAMQ-----------RVREKLGSENLAAQREQ----LLEAVADLTQ 144
Cdd:PRK10403   86 LTvsdaSSDVFAL--IDAGADGYLLKDSDPEVLLEAIRagakgskvfseRVNQYLREREMFGAEEDpfsvLTERELDVLH 163

                         170       180
                  ....*....|....*....|....*...
gi 1151112976 145 ESPESLEVKLAAGELGGSRFPEKIAIKD 172
Cdd:PRK10403  164 ELAQGLSNKQIASVLNISEQTVKVHIRN 191
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 7-112 1.26e-10

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 57.55  E-value: 1.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENlGGVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDE----MPqIV 82
Cdd:cd17548     1 KILIVEDNPLNMKLARDLLES-AGYEVL-EAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEDPatrdIP-VI 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1151112976  83 FVTAY----DQYavEAFEVNAVDYVLKPIEEDRL 112
Cdd:cd17548    78 ALTAYamkgDRE--KILEAGCDGYISKPIDTREF 109
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 8-121 1.30e-10

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 57.51  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARrglrlrlENLGGV---E--VVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQIV 82
Cdd:cd17550     1 ILIVDDEEDIR-------ESLSGIledEgyEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEI-KEKYPDLP 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1151112976  83 FV---------TaydqyAVEAFEVNAVDYVLKPIEEDRLSRAMQRVRE 121
Cdd:cd17550    73 VImisghgtieT-----AVKATKLGAYDFIEKPLSLDRLLLTIERALE 115
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 8-118 2.40e-10

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 56.59  E-value: 2.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLE-LVQLLPKDEMPQIVFVTA 86
Cdd:cd19931     1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDtLKALREEGVSARIVILTV 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1151112976  87 YD--QYAVEAFEVNAVDYVLKPIEEDRLSRAMQR 118
Cdd:cd19931    81 SDaeDDVVTALRAGADGYLLKDMEPEDLLEALKQ 114
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 7-106 3.24e-10

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 56.49  E-value: 3.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENlGGVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ---IVF 83
Cdd:cd17618     2 TILIVEDEPAIREMIAFNLER-AGFDVV-EAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEMTRdipIIM 79

                          90       100
                  ....*....|....*....|....*..
gi 1151112976  84 VTA----YDQyaVEAFEVNAVDYVLKP 106
Cdd:cd17618    80 LTArgeeEDK--VRGLEAGADDYITKP 104
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 4-156 3.67e-10

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 59.04  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   4 DSLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMP---GVTGLELVQLLPKDEMPQ 80
Cdd:TIGR02875   1 HKIRIVIADDNKEFCNLLKEYLAAQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPhldGIGVLEKLNEIELSARPR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1151112976  81 IVFVTAYDQYAV--EAFEVNAVDYVLKPIEedrlsramqrvreklgSENLAAQREQLLE-AVADLTQESPESLEVKLAA 156
Cdd:TIGR02875  81 VIMLSAFGQEKItqRAVALGADYYVLKPFD----------------LEILAARIRQLAWgTNADILADSPTVPPASHAA 143
orf27 CHL00148
Ycf27; Reviewed
 1-127 3.76e-10

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 58.57  E-value: 3.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   1 MSSDSLKVIIVDDEPLARRGLRLRLeNLGGVEVVAECgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ 80
Cdd:CHL00148    2 MENSKEKILVVDDEAYIRKILETRL-SIIGYEVITAS-DGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVP 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1151112976  81 IVFVTAYDQYA--VEAFEVNAVDYVLKPIEEDRLSramQRVREKLGSEN 127
Cdd:CHL00148   80 IIMLTALGDVSdrITGLELGADDYVVKPFSPKELE---ARIRSVLRRTN 125
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 8-122 1.33e-09

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 54.80  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLEnLGGVEVVAeCGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK--DEMPqIVFVT 85
Cdd:cd17549     1 VLLVDDDADVREALQQTLE-LAGFRVRA-FADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIREldPDLP-VILIT 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1151112976  86 AY-D-QYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREK 122
Cdd:cd17549    78 GHgDvPMAVEAMRAGAYDFLEKPFDPERLLDVVRRALEK 116
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 7-115 1.88e-09

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 53.99  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQ--IVFV 84
Cdd:cd17563     2 SLLLVDDDEVFAERLARALERRG--FEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPL-RALQPDarIVVL 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1151112976  85 TAYDQY--AVEAFEVNAVDYVLKPIEEDRLSRA 115
Cdd:cd17563    79 TGYASIatAVEAIKLGADDYLAKPADADEILAA 111
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 57-118 7.51e-09

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 52.60  E-value: 7.51e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1151112976  57 LDIQMPGVTGLELV-QLLPKDEMPQIVFVTAY-D-QYAVEAFEVNAVDYVLKPIEEDRLSRAMQR 118
Cdd:cd17537    50 LDVRMPGMSGLELQdELLARGSNIPIIFITGHgDvPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQ 114
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 7-109 1.05e-08

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 52.35  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLEnLGGVEVVAeCGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEM--PqIVFV 84
Cdd:cd17615     1 RVLVVDDEPNITELLSMALR-YEGWDVET-AADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPdvP-VLFL 77

                          90       100
                  ....*....|....*....|....*....
gi 1151112976  85 TAYD--QYAVEAFEVNAVDYVLKP--IEE 109
Cdd:cd17615    78 TAKDsvEDRIAGLTAGGDDYVTKPfsLEE 106
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 39-162 2.54e-08

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 54.11  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  39 NGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQ--IVFVTAYDQY--AVEAFEVNAVDYVLKPIEEDR--- 111
Cdd:PRK10923   35 NGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQI-KQRHPMlpVIIMTAHSDLdaAVSAYQQGAFDYLPKPFDIDEava 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1151112976 112 -LSRAMQRVREKLGSENlaaqrEQLLEAVADLTQESPESLEVKLAAGELGGS 162
Cdd:PRK10923  114 lVERAISHYQEQQQPRN-----IQVNGPTTDIIGEAPAMQDVFRIIGRLSRS 160
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 8-118 2.72e-08

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 50.84  E-value: 2.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLEnLGGVEVvAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK--DEMPqIVFVT 85
Cdd:cd17627     1 ILVVDDDRAVRESLRRSLR-FEGYEV-ETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAagNDLP-ILVLT 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1151112976  86 AYDQYA--VEAFEVNAVDYVLKPIEEDRL---SRAMQR 118
Cdd:cd17627    78 ARDSVSdrVAGLDAGADDYLVKPFALEELlarVRALLR 115
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 8-115 3.88e-08

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 50.53  E-value: 3.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL---PKDEMPQIVFV 84
Cdd:cd17580     1 ILVVDDNEDAAEMLALLLELEG--AEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLrelPWLANTPAIAL 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1151112976  85 TAY-----DQYAVEA-FEvnavDYVLKPIEEDRLSRA 115
Cdd:cd17580    79 TGYgqpedRERALEAgFD----AHLVKPVDPDELIEL 111
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 10-107 4.06e-08

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 50.35  E-value: 4.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  10 IVDDEPLARRGLRLRLENlGGVEVVAeCGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ---IVFVTA 86
Cdd:cd19937     2 VVDDEEDIVELLKYNLEK-EGYEVVT-AYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSsipIIMLTA 79

                          90       100
                  ....*....|....*....|...
gi 1151112976  87 YDQYA--VEAFEVNAVDYVLKPI 107
Cdd:cd19937    80 KGEEFdkVLGLELGADDYITKPF 102
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
1-118 4.40e-08

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 53.50  E-value: 4.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   1 MSSDSLKVIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLE-LVQLLPKDEMP 79
Cdd:PRK10365    1 MTHDNIDILVVDDDISHCTILQALLRGWG--YNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIAtLKEIKALNPAI 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1151112976  80 QIVFVTAYD--QYAVEAFEVNAVDYVLKPIEEDRLSRAMQR 118
Cdd:PRK10365   79 PVLIMTAYSsvETAVEALKTGALDYLIKPLDFDNLQATLEK 119
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 7-86 6.21e-08

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 50.24  E-value: 6.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ---IVF 83
Cdd:cd17552     3 RILVIDDEEDIREVVQACLEKLAGWEVL-TASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQANPETQsipVIL 81


                  ...
gi 1151112976  84 VTA 86
Cdd:cd17552    82 LTA 84
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 7-123 6.28e-08

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 49.78  E-value: 6.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVevVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTA 86
Cdd:cd17626     2 RILVVDDDAALAEMIGIVLRGEGFD--PAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVMLTA 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1151112976  87 YDQYA--VEAFEVNAVDYVLKPIEEDRLsraMQRVREKL 123
Cdd:cd17626    80 KSDTVdvVLGLESGADDYVAKPFKPKEL---VARIRARL 115
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 6-62 6.75e-08

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 47.95  E-value: 6.75e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1151112976    6 LKVIIVDDEPLARRGLRLRLENLGGVevVAECGNGREAKEQIEQLKPDVAFLDIQMP 62
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYE--VDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 8-115 8.74e-08

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 49.31  E-value: 8.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTAY 87
Cdd:cd17619     3 ILIVEDEPVTRATLKSYFEQEG--YDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVGIILVTGR 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1151112976  88 DQYA--VEAFEVNAVDYVLKPIE-EDRLSRA 115
Cdd:cd17619    81 DDEVdrIVGLEIGADDYVTKPFNpRELLVRA 111
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
9-86 9.84e-08

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 51.05  E-value: 9.84e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1151112976   9 IIVDDEPLARRGLRLRLENlGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTA 86
Cdd:PRK09958    4 IIIDDHPLAIAAIRNLLIK-NDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVS 80
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 6-123 1.06e-07

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 49.54  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENL----GGVEVVAECGNGREAKEQIEQLKP---DVAFLDIQMPGVTGLELVQLLPK-DE 77
Cdd:cd17533     1 MNIFILEDDKIQRVRLEEIIENIlkieNIEYVIELTGKTEELLEKIKERGKngiYFLDIDIKMEEKNGLEVAQKIRKyDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1151112976  78 MPQIVFVTAYDQYAVEAFE--VNAVDYVLKPIEEDRLSramQRVREKL 123
Cdd:cd17533    81 YAIIIFVTTHSEFAPLTFEykVAALDFILKPLKLEEFK---KRIEECI 125
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 6-119 1.45e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 48.87  E-value: 1.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGgVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDE----MPqI 81
Cdd:cd19923     1 MKVLVVDDFSTMRRIIKNLLKELG-FNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGalshLP-V 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1151112976  82 VFVT--AYDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRV 119
Cdd:cd19923    79 LMVTaeAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKI 118
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 37-121 1.56e-07

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 48.95  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  37 CGNGREA-------KEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDE----MPQIVFVTAYDQYAVE-AFEVNAVDYVL 104
Cdd:cd17557    31 VRDGEEAldflrgeGEYADAPRPDLILLDLNMPRMDGFEVLREIKADPdlrrIPVVVLTTSDAEEDIErAYELGANSYIV 110

                          90
                  ....*....|....*..
gi 1151112976 105 KPIEEDRLSRAMQRVRE 121
Cdd:cd17557   111 KPVDFEEFVEAIRSLGE 127
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 34-119 1.66e-07

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 48.69  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  34 VAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTAYD--QYAVE-AFEVNAVDYVLKPIEED 110
Cdd:cd17593    28 ITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVVSGDvqPEAKErVLELGALAFLKKPFDPE 107


                  ....*....
gi 1151112976 111 RLSRAMQRV 119
Cdd:cd17593   108 KLAQLLEEL 116
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 5-118 2.16e-07

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 51.77  E-value: 2.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   5 SLKVIIVDDEPLARRGLRLRLENLggVEVVAECGNGREAKEQIEQLKPDVAFLDIQMP---GVTGLELVQLLPKDEMPQI 81
Cdd:PRK11107  667 PLTVMAVDDNPANLKLIGALLEEQ--VEHVVLCDSGHQAVEQAKQRPFDLILMDIQMPgmdGIRACELIRQLPHNQNTPI 744

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1151112976  82 VFVTAY------DQYAVEAFEvnavDYVLKPIEEDRLSRAMQR 118
Cdd:PRK11107  745 IAVTAHamagerERLLSAGMD----DYLAKPIDEAMLKQVLLR 783
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 34-118 2.29e-07

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 48.37  E-value: 2.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  34 VAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKD--EMPqIVFVTAYD--QYAVEAFEVNAVDYVLKPIEE 109
Cdd:cd17625    24 VDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEgiETP-VLLLTALDavEDRVKGLDLGADDYLPKPFSL 102

                          90
                  ....*....|..
gi 1151112976 110 DRLS---RAMQR 118
Cdd:cd17625   103 AELLariRALLR 114
PRK10693 PRK10693
two-component system response regulator RssB;
35-149 3.59e-07

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 50.37  E-value: 3.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  35 AECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELV-QLLPKDEMPQIVFVTAYDQYA--VEAFEVNAVDYVLKPIeedr 111
Cdd:PRK10693    1 VLAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVeHLRNRGDQTPVLVISATENMAdiAKALRLGVQDVLLKPV---- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1151112976 112 lsRAMQRVREKLGS-------ENLAAQREQLLEAVADLtQESPES 149
Cdd:PRK10693   77 --KDLNRLREMVFAclypsmfNSRVEEEERLFRDWDAL-VDNPAA 118
fixJ PRK09390
response regulator FixJ; Provisional
 58-159 4.96e-07

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 49.23  E-value: 4.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  58 DIQMPGVTGLELV-QLLPKDEMPQIVFVTAYDQ--YAVEAFEVNAVDYVLKPIEEDRL----SRAMQRVREKLGSENLAA 130
Cdd:PRK09390   54 DVRMPGIDGIELLrRLKARGSPLPVIVMTGHGDvpLAVEAMKLGAVDFIEKPFEDERLigaiERALAQAPEAAKSEAVAA 133

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1151112976 131 ----------QRE-QLLEA-VADLTQE--------SPESLEV-------KLAAGEL 159
Cdd:PRK09390  134 dirariaslsERErQVMDGlVAGLSNKviardldiSPRTVEVyranvmtKMQAGSL 189
PRK10766 PRK10766
two-component system response regulator TorR;
5-142 4.99e-07

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 49.27  E-value: 4.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   5 SLKVIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFV 84
Cdd:PRK10766    2 SYHILVVEDEPVTRARLQGYFEQEG--YTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  85 TAYDQY--AVEAFEVNAVDYVLKPIEedrLSRAMQRVREKLGSENLAAQREQLLEAVADL 142
Cdd:PRK10766   80 TGRTDSidRIVGLEMGADDYVTKPLE---LRELLVRVKNLLWRISLARQAQPHAQEEDNC 136
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 8-106 8.21e-07

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 46.65  E-value: 8.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAEcgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELV-QLLPKDEMPqIVFVTA 86
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTKEGYEVVTAY--DGREALEKVEEEQPDLILLDLMLPEKDGLEVCrEVRKTSNVP-IIMLTA 77

                          90       100
                  ....*....|....*....|..
gi 1151112976  87 YDQY--AVEAFEVNAVDYVLKP 106
Cdd:cd17614    78 KDSEvdKVLGLELGADDYVTKP 99
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 30-108 8.47e-07

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 46.60  E-value: 8.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  30 GVEVVAEcGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTAY--DQYAVEAFEVNAVDYVLKPI 107
Cdd:cd17622    24 GFNVVVE-HRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLLTALdsDIDHILGLELGADDYVVKPV 102


                  .
gi 1151112976 108 E 108
Cdd:cd17622   103 E 103
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 33-106 9.05e-07

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 46.28  E-value: 9.05e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1151112976  33 VVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL--PKDEMPqIVFVTAYDQYA--VEAFEVNAVDYVLKP 106
Cdd:cd19935    24 AVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLraAGKQTP-VLMLTARDSVEdrVKGLDLGADDYLVKP 100
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
7-106 1.63e-06

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 48.34  E-value: 1.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKdEMP-QIVFVT 85
Cdd:PRK12555    2 RIGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMA-ERPcPILIVT 80

                          90       100
                  ....*....|....*....|....*
gi 1151112976  86 AYDQYAV----EAFEVNAVDYVLKP 106
Cdd:PRK12555   81 SLTERNAsrvfEAMGAGALDAVDTP 105
PRK10360 PRK10360
transcriptional regulator UhpA;
31-162 1.67e-06

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 47.66  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  31 VEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEmpQIVFVTAYDQYAV--EAFEVNAVDYVLKPIE 108
Cdd:PRK10360   27 LQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGM--ATIMLSVHDSPALveQALNAGARGFLSKRCS 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1151112976 109 EDRLSRAMQRV-------REKLGSENLAAQREQLLEAVADLTQESPESLEVKLAAGELGGS 162
Cdd:PRK10360  105 PDELIAAVHTVatggcylTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLS 165
PRK10610 PRK10610
chemotaxis protein CheY;
1-124 2.76e-06

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 45.74  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   1 MSSDSLKVIIVDDEPLARRGLRLRLENLGgVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKD---- 76
Cdd:PRK10610    1 MADKELKFLVVDDFSTMRRIVRNLLKELG-FNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADgams 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1151112976  77 EMPqIVFVT--AYDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKLG 124
Cdd:PRK10610   80 ALP-VLMVTaeAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEKLG 128
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 10-84 3.07e-06

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 44.96  E-value: 3.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1151112976  10 IVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQIVFV 84
Cdd:cd17565     3 IVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKL-KDTGSNGKFI 76
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 8-109 3.46e-06

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 44.97  E-value: 3.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAEcgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDE--MPqIVFVT 85
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLSDAGYVVDVAE--DGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGraTP-VLILT 77

                          90       100
                  ....*....|....*....|....*...
gi 1151112976  86 AYDQYA--VEAFEVNAVDYVLKP--IEE 109
Cdd:cd19934    78 ARDSWQdkVEGLDAGADDYLTKPfhIEE 105
PRK13435 PRK13435
response regulator; Provisional
 1-123 5.18e-06

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 45.04  E-value: 5.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   1 MSSDSLKVIIVDDEPLARRGLRLRLENLGgVEVVAECGNGREAKEQIEQLKPDVAFLDIQ-MPGVTGLELVQLLPKDEMP 79
Cdd:PRK13435    1 MFLRQLKVLIVEDEALIALELEKLVEEAG-HEVVGIAMSSEQAIALGRRRQPDVALVDVHlADGPTGVEVARRLSADGGV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1151112976  80 QIVFVTAYDQYAVEAFEvNAVDYVLKPIEEDRLSRAMQRVREKL 123
Cdd:PRK13435   80 EVVFMTGNPERVPHDFA-GALGVIAKPYSPRGVARALSYLSARR 122
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 8-106 5.47e-06

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 44.07  E-value: 5.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAEcgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDEMPQ--IVFVT 85
Cdd:cd19926     1 VLVVDDEPDIRELLEITLGRMGLDVRSAR--NVKEARELLASEPYDLCLTDMRLPDGSGLELVQHI-QQRLPQtpVAVIT 77

                          90       100
                  ....*....|....*....|....
gi 1151112976  86 AY---DQyAVEAFEVNAVDYVLKP 106
Cdd:cd19926    78 AYgslDT-AIEALKAGAFDFLTKP 100
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 7-119 5.68e-06

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 44.60  E-value: 5.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENlGGVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKdeMPQ-----I 81
Cdd:cd17562     2 KILAVDDSASIRQMVSFTLRG-AGYEVV-EAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRK--LPAykftpI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1151112976  82 VFVT--AYDQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRV 119
Cdd:cd17562    78 LMLTteSSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKV 117
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 34-118 9.76e-06

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 43.63  E-value: 9.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  34 VAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ-IVFVTAYDQYA--VEAFEVNAVDYVLKPIEED 110
Cdd:cd17624    25 VDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLpVLILTARDGVDdrVAGLDAGADDYLVKPFALE 104

                          90
                  ....*....|.
gi 1151112976 111 RLS---RAMQR 118
Cdd:cd17624   105 ELLarlRALLR 115
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 7-108 1.00e-05

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 43.90  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENlGGVEVVAEcGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTA 86
Cdd:cd19939     1 RILIVEDELELARLTRDYLIK-AGLEVSVF-TDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHVPILMLTA 78

                          90       100
                  ....*....|....*....|....*.
gi 1151112976  87 ----YDQyaVEAFEVNAVDYVLKPIE 108
Cdd:cd19939    79 rteeMDR--VLGLEMGADDYLCKPFS 102
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 7-87 1.14e-05

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 43.39  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGgVEVVAECGNGREAKEQIEQLKPDVAFLDIQMP-GVTGLELVQLLPKDEMPQIVFVT 85
Cdd:cd17540     2 RVLIIEDEPLIAMDLEQIVEDLG-HQVVGIARTRDEAVALARRERPDLILADIQLAdGSSGIDAVNEILTTHDVPVIFVT 80


                  ..
gi 1151112976  86 AY 87
Cdd:cd17540    81 AY 82
pleD PRK09581
response regulator PleD; Reviewed
 34-120 1.46e-05

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 45.66  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  34 VAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKD----EMPqIVFVTAYDQYA--VEAFEVNAVDYVLKPI 107
Cdd:PRK09581   29 VLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSDpattHIP-VVMVTALDDPEdrVRGLEAGADDFLTKPI 107

                          90
                  ....*....|...
gi 1151112976 108 EEDRLsraMQRVR 120
Cdd:PRK09581  108 NDVAL---FARVK 117
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 39-106 1.46e-05

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 42.82  E-value: 1.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1151112976  39 NGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQ-LLPKDEMPqIVFVTAYDQYAVEAF--EVNAVDYVLKP 106
Cdd:cd19936    30 DGASALDGLNARPPDLAILDIKMPRMDGMELLQrLRQKSTLP-VIFLTSKDDEIDEVFglRMGADDYITKP 99
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 8-86 1.85e-05

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 42.75  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENlGGVEVVAECgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDE----MPqIVF 83
Cdd:cd19927     1 ILLVDDDPGIRLAVKDYLED-QGFTVIAAS-NGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNAdfdtIP-VIF 77


                  ...
gi 1151112976  84 VTA 86
Cdd:cd19927    78 LTA 80
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 8-106 1.92e-05

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 42.54  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK-DEMPQIVfVTA 86
Cdd:cd17620     1 ILVIEDEPQIRRFLRTALEAHG--YRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREwSAVPVIV-LSA 77

                          90       100
                  ....*....|....*....|..
gi 1151112976  87 YDQYA--VEAFEVNAVDYVLKP 106
Cdd:cd17620    78 RDEESdkIAALDAGADDYLTKP 99
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 36-118 2.81e-05

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 42.54  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  36 ECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK-DEMPQIVFVTAYDQYAV--EAFEVNAVDYVLKPIEEDRL 112
Cdd:cd17553    29 QAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKViDENIRVIIMTAYGELDMiqESKELGALTHFAKPFDIDEI 108


                  ....*.
gi 1151112976 113 SRAMQR 118
Cdd:cd17553   109 RDAVKK 114
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 8-106 3.65e-05

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 41.95  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQ-LKPDVAFLDIQMPG-VTGLELVQLLpKDEMPQI--VF 83
Cdd:cd18161     1 VLVVEDDPDVRRLTAEVLEDLG--YTVLEAASGDEALDLLESgPDIDLLVTDVIMPGgMNGSQLAEEA-RRRRPDLkvLL 77

                          90       100
                  ....*....|....*....|....
gi 1151112976  84 VTAYDQYAVEA-FEVNAVDYVLKP 106
Cdd:cd18161    78 TSGYAENAIEGgDLAPGVDVLSKP 101
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 30-105 3.69e-05

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 43.86  E-value: 3.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1151112976  30 GVEVVAEcGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQ-LLPKDEMPqIVFVTAYDQ--YAVEAFEVNAVDYVLK 105
Cdd:PRK10701   25 DIDVTVE-PRGDRAEATILREQPDLVLLDIMLPGKDGMTICRdLRPKWQGP-IVLLTSLDSdmNHILALEMGACDYILK 101
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 8-120 4.36e-05

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 41.93  E-value: 4.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAecGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDE----MPQIVF 83
Cdd:cd17598     1 ILIVEDSPTQAEQLKHILEEQGYKVQVA--RNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPdlkdIPVILL 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1151112976  84 VTAYD-QYAVEAFEVNAVDYVLKPIEEDRLsraMQRVR 120
Cdd:cd17598    79 TTLSDpRDVIRGLECGADNFITKPYDEKYL---LSRIK 113
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
7-123 6.61e-05

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 43.17  E-value: 6.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVEVVAEcgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ---IVF 83
Cdd:PRK10161    4 RILVVEDEAPIREMVCFVLEQNGFQPVEAE--DYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRdipVVM 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1151112976  84 VTAY--DQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVREKL 123
Cdd:PRK10161   82 LTARgeEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRI 123
PRK09483 PRK09483
response regulator; Provisional
 6-68 1.12e-04

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 42.40  E-value: 1.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLE 68
Cdd:PRK09483    2 INVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLE 64
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 39-106 1.24e-04

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 40.73  E-value: 1.24e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  39 NGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTAYDQYA--VEAFEVNAVDYVLKP 106
Cdd:cd18159    30 DFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISNVPIIFISSRDDNMdqVMAINMGGDDYITKP 99
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 37-106 1.25e-04

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 42.26  E-value: 1.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1151112976  37 CGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELV-QLLP-KDEMPqIVFVTAYDQYA--VEAFEVNAVDYVLKP 106
Cdd:PRK11083   33 FERGLPALDKLRQQPPDLVILDVGLPDISGFELCrQLLAfHPALP-VIFLTARSDEVdrLVGLEIGADDYVAKP 105
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 34-106 2.32e-04

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 39.49  E-value: 2.32e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1151112976  34 VAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELV-QLLPKDEMPqIVFVTAYDQY--AVEAFEVNAVDYVLKP 106
Cdd:cd17621    25 VTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCrQLRARSNVP-VIMVTAKDSEidKVVGLELGADDYVTKP 99
PRK10816 PRK10816
two-component system response regulator PhoP;
6-118 2.66e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 41.26  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAEcgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ-IVFV 84
Cdd:PRK10816    1 MRVLVVEDNALLRHHLKVQLQDAGHQVDAAE--DAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLpILVL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1151112976  85 TAYD--QYAVEAFEVNAVDYVLKP--IEE--DRLSRAMQR 118
Cdd:PRK10816   79 TAREswQDKVEVLSAGADDYVTKPfhIEEvmARMQALMRR 118
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 6-112 2.72e-04

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 39.73  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAEcGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMP-QIVFV 84
Cdd:cd17530     1 LRVLVLDDDPFQCMMAATILEDLGPGNVDEA-DDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNaAVILM 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1151112976  85 TAYDQYAVEAFEVNAVDYVL-------KPIEEDRL 112
Cdd:cd17530    80 SGLDGGILESAETLAGANGLnllgtlsKPFSPEEL 114
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 8-106 3.33e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 39.28  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLgGVEvVAECGNGREAKEQIEQLKP---------DVAFLDIQMPGVTGLELVQLLPKD-- 76
Cdd:cd19924     1 ILVVDDSPTARKQLRDLLKNL-GFE-IAEAVDGEEALNKLENLAKegndlskelDLIITDIEMPKMDGYELTFELRDDpr 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1151112976  77 --EMPQIVFVTAYDQYAVE-AFEVNAVDYVLKP 106
Cdd:cd19924    79 laNIPVILNSSLSGEFSRArGKKVGADAYLAKF 111
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 37-105 4.28e-04

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 39.31  E-value: 4.28e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1151112976  37 CGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKD----EMPQIVFVTAYD-QYAVEAFEVNAVDYVLK 105
Cdd:cd17575    31 CSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANpatrDIPIIVLSTKEEpEVKSEAFALGANDYLVK 104
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 5-86 4.82e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 41.46  E-value: 4.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   5 SLKVIIVDDEPLARRGLRLRLENLGGVEVVAECGngreaKEQIEQLKP---DVAFLDIQMPGVTGLELVQLL----PKDE 77
Cdd:PRK11091  525 ALNILLVEDIELNVIVARSVLEKLGNSVDVAMTG-----KEALEMFDPdeyDLVLLDIQLPDMTGLDIARELreryPRED 599


                  ....*....
gi 1151112976  78 MPQIVFVTA 86
Cdd:PRK11091  600 LPPLVALTA 608
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 7-112 6.17e-04

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 38.54  E-value: 6.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPlarrglrlrlENL---------GGVEVVaECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLpKDE 77
Cdd:cd17569     2 TILLVDDEP----------NILkalkrllrrEGYEVL-TATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRV-RER 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1151112976  78 MPQIV--FVTAY-D-QYAVEAfeVNAVD---YVLKPIEEDRL 112
Cdd:cd17569    70 YPDTVriLLTGYaDlDAAIEA--INEGEiyrFLTKPWDDEEL 109
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 30-118 7.14e-04

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 38.44  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  30 GVEVVAeCGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTAY--DQYAVEAFEVNAVDYVLKPI 107
Cdd:cd17623    22 GFNVRA-AHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLMLTARgdDIDRILGLELGADDYLPKPF 100

                          90
                  ....*....|....
gi 1151112976 108 EEDRLS---RAMQR 118
Cdd:cd17623   101 NPRELVariRAILR 114
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 7-106 1.23e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 37.74  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLG-GVEVVAecgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVT 85
Cdd:cd19938     1 RILIVEDEPKLAQLLIDYLRAAGyAPTLLA---HGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDVPIIMVT 77

                          90       100
                  ....*....|....*....|....*..
gi 1151112976  86 AydqyAVE------AFEVNAVDYVLKP 106
Cdd:cd19938    78 A----RVEeidrllGLELGADDYICKP 100
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 30-119 1.28e-03

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 37.61  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  30 GVEVVAeCGNGREAKEQIEQLKP--DVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTAYDQ--YAVEAFEVNAVDYVLK 105
Cdd:cd17584    22 GYQVTT-CTDAEEALSMLRENKDefDLVITDVHMPDMDGFEFLELIRLEMDLPVIMMSADGStsTVMKGLAHGACDYLLK 100

                          90
                  ....*....|....
gi 1151112976 106 PIEEDRLSRAMQRV 119
Cdd:cd17584   101 PVSIEDLKNIWQHV 114
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 6-143 1.30e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 39.14  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   6 LKVIIVDDEPLARRGLRLRLENLGGVEVVAEcgNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL--PKDEMPqIVF 83
Cdd:PRK09836    1 MKLLIVEDEKKTGEYLTKGLTEAGFVVDLAD--NGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLrsANKGMP-ILL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1151112976  84 VTAYD--QYAVEAFEVNAVDYVLKPIEedrLSRAMQRVREKLGSENLAAQREQLleAVADLT 143
Cdd:PRK09836   78 LTALGtiEHRVKGLELGADDYLVKPFA---FAELLARVRTLLRRGAAVIIESQF--QVADLM 134
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 34-109 1.87e-03

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 37.50  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  34 VAECGNGREAKEQIEQlKPDVAFL--DIQMPGVTGLELVQLL----PKDEMPqIVFVTAYDQYAVEA-FEVN-AVDYVLK 105
Cdd:cd17544    27 VLEAANGQEALEVLEQ-HPDIKLVitDYNMPEMDGFELVREIrkkySRDQLA-IIGISASGDNALSArFIKAgANDFLTK 104


                  ....*.
gi 1151112976 106 P--IEE 109
Cdd:cd17544   105 PflPEE 110
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 7-120 2.70e-03

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 36.66  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVEVVAecGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLL-PKDEMPQIVFVT 85
Cdd:cd17594     1 HVLVVDDDAAMRHLLILYLRERGFDVTAA--ADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIrARSDVPIIIISG 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1151112976  86 AYDQYA--VEAFEVNAVDYVLKPIEedrLSRAMQRVR 120
Cdd:cd17594    79 DRRDEIdrVVGLELGADDYLAKPFG---LRELLARVR 112
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
 8-120 4.84e-03

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 35.91  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGvEVVAECGNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPqIVFVTAY 87
Cdd:cd17586     1 VLVLEDEPLIAMNLEDALEDLGG-KEVVTAATCAEALRSLADGPIDIAILDVNLGGETSIPVADALKRRAIP-FIFATGY 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1151112976  88 DQYAVEAFEVNAVDYVLKPIEEDRLSRAMQRVR 120
Cdd:cd17586    79 GDSHGIDSRLIDVPVLRKPFDADSALAALAMLL 111
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
7-134 4.90e-03

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 37.47  E-value: 4.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGGVEVVAecGNGREAKEQIEQlKPDVAFLDIQMPGVTGLELVQLLPKDEMPQIVFVTA 86
Cdd:PRK10955    3 KILLVDDDRELTSLLKELLEMEGFNVIVA--HDGEQALDLLDD-SIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1151112976  87 --YDQYAVEAFEVNAVDYVLKPIEEDRLsraMQRVREKLGSENLAAQREQ 134
Cdd:PRK10955   80 rgSELDRVLGLELGADDYLPKPFNDREL---VARIRAILRRSHWSEQQQN 126
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 7-99 5.17e-03

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 35.56  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   7 KVIIVDDEPLARRGLRLRLENLGgvEVVAECGNGREAKEQIEQLKP-DVAFLDIQMPGVTGLELVQLLPK-DEMPQIVFV 84
Cdd:cd18160     1 TILLADDEPSVRKFIVTTLKKAG--YAVTEAESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREARKiDPDVKILFI 78

                          90
                  ....*....|....*
gi 1151112976  85 TAydqYAVEAFEVNA 99
Cdd:cd18160    79 SG---GAAAAPELLS 90
PRK10430 PRK10430
two-component system response regulator DcuR;
8-133 5.53e-03

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 37.40  E-value: 5.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976   8 VIIVDDEPLARRGLRLRLENLGGVEVVAECGNGREAKEQI--EQLKPDVAFLDIQMPGVTGLELVQLLPKDEMPQ--IVF 83
Cdd:PRK10430    4 VLIVDDDAMVAELNRRYVAQIPGFQCCGTASTLEQAKEIIfnSDTPIDLILLDIYMQQENGLDLLPVLHEAGCKSdvIVI 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1151112976  84 VTAYDQYAVE-AFEVNAVDYVLKPIEEDRLSRAMQRVREKlgsENLAAQRE 133
Cdd:PRK10430   84 SSAADAATIKdSLHYGVVDYLIKPFQASRFEEALTGWRQK---KMALEKHQ 131
PRK15479 PRK15479
transcriptional regulator TctD;
38-128 6.13e-03

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 37.01  E-value: 6.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  38 GNGREAKEQIEQLKPDVAFLDIQMPGVTGLELVQLLPK--DEMPqIVFVTAYDQYA--VEAFEVNAVDYVLKPIEEDRLS 113
Cdd:PRK15479   31 FDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKrgQTLP-VLLLTARSAVAdrVKGLNVGADDYLPKPFELEELD 109

                          90
                  ....*....|....*...
gi 1151112976 114 ---RAMQRVREKLGSENL 128
Cdd:PRK15479  110 arlRALLRRSAGQVQEVQ 127
PRK10336 PRK10336
two-component system response regulator QseB;
40-126 7.03e-03

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 36.80  E-value: 7.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  40 GREAKEQIEQLKPDVAFLDIQMPGVTGLELV-QLLPKDEMPQIVFVTAYDQYA--VEAFEVNAVDYVLKP---IE-EDRL 112
Cdd:PRK10336   33 GRQGKEALYSAPYDAVILDLTLPGMDGRDILrEWREKGQREPVLILTARDALAerVEGLRLGADDYLCKPfalIEvAARL 112

                          90
                  ....*....|....
gi 1151112976 113 SRAMQRVREKLGSE 126
Cdd:PRK10336  113 EALMRRTNGQASNE 126
PRK11517 PRK11517
DNA-binding response regulator HprR;
50-146 7.98e-03

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 36.80  E-value: 7.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151112976  50 LKPDVAF--LDIQMPGVTGLELVQLLPKDEMPQIVFVTAYDQYA--VEAFEVNAVDYVLKPIEedrLSRAMQRVREKLGS 125
Cdd:PRK11517   41 LKDDYALiiLDIMLPGMDGWQILQTLRTAKQTPVICLTARDSVDdrVRGLDSGANDYLVKPFS---FSELLARVRAQLRQ 117

                          90       100
                  ....*....|....*....|.
gi 1151112976 126 ENLAAQREQlleaVADLTQES 146
Cdd:PRK11517  118 HHALNSTLE----ISGLRMDS 134
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 50-106 8.07e-03

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 35.04  E-value: 8.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1151112976  50 LKPDVAFLDIQMPGVTGLELVQLLPKD----EMPqIVFVTAYDQYA--VEAFEVNAVDYVLKP 106
Cdd:cd17602    41 SKPDLILIDIDMPDLDGYELCSLLRKSsalkDTP-IIMLTGKDGLVdrIRAKMAGASGYLTKP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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