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Conserved domains on  [gi|1149889047|ref|XP_020140831|]
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LOW QUALITY PROTEIN: zinc finger protein 674-like [Microcebus murinus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-383 3.51e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 3.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149889047 207 PNQQRKALHHNRaLDKSQRIQSGEKLNeCAECGKVFIQRANLIVHQR--IHTGE--KPYECCE--CAKAFSQKSTLIAHQ 280
Cdd:COG5048   266 PTASSQSSSPNE-SDSSSEKGFSLPIK-SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149889047 281 RTHTGEKPYEC--SECGKTFIQK------ALLIKHQRIHTGerPYKCCD---CEKAFIRKLTLIKHQKSHTGEKPYECN- 348
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKND--KKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1149889047 349 -ECGKSCSVKSSLIVHYRTHTVEKAYECRDWKSLHS 383
Cdd:COG5048   422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-383 3.51e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 3.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149889047 207 PNQQRKALHHNRaLDKSQRIQSGEKLNeCAECGKVFIQRANLIVHQR--IHTGE--KPYECCE--CAKAFSQKSTLIAHQ 280
Cdd:COG5048   266 PTASSQSSSPNE-SDSSSEKGFSLPIK-SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149889047 281 RTHTGEKPYEC--SECGKTFIQK------ALLIKHQRIHTGerPYKCCD---CEKAFIRKLTLIKHQKSHTGEKPYECN- 348
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKND--KKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1149889047 349 -ECGKSCSVKSSLIVHYRTHTVEKAYECRDWKSLHS 383
Cdd:COG5048   422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-300 2.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|..
gi 1149889047 279 HQRTHTGEKPYECSECGKTFIQ 300
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-383 3.51e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 3.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149889047 207 PNQQRKALHHNRaLDKSQRIQSGEKLNeCAECGKVFIQRANLIVHQR--IHTGE--KPYECCE--CAKAFSQKSTLIAHQ 280
Cdd:COG5048   266 PTASSQSSSPNE-SDSSSEKGFSLPIK-SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149889047 281 RTHTGEKPYEC--SECGKTFIQK------ALLIKHQRIHTGerPYKCCD---CEKAFIRKLTLIKHQKSHTGEKPYECN- 348
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKND--KKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1149889047 349 -ECGKSCSVKSSLIVHYRTHTVEKAYECRDWKSLHS 383
Cdd:COG5048   422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-394 5.13e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149889047 259 KPYECCECAKAFSQKSTLIAHQRT--HTGE--KPYECSE--CGKTFIQKALLIKHQRIHTGERPYKCC--DCEKAFIRKL 330
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1149889047 331 T-----LIKHQKSHTGEKPYEC--NECGKSCSVKSSLIVHYRTHTVEKAYECRDWK--SLHSGKTSLIKHQRS 394
Cdd:COG5048   368 NneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPcsKSFNRHYNLIPHKKI 440
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-359 7.04e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 7.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149889047 271 SQKSTLIAHQRTHTGE----KPYECSECGKTFIQKALLIKHQRIHTGERPYKC--CDCEKAFIRKLTLIKHQKSHTGEKP 344
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91

                          90
                  ....*....|....*
gi 1149889047 345 YECNECGKSCSVKSS 359
Cdd:COG5048    92 DLNSKSLPLSNSKAS 106
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-292 1.31e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1149889047 222 KSQRIQSGEK--LNECAECGKVFIQRANLIVHQRIHTGEKPYEC--CECAKAFSQKSTLIAHQRTHTGEKPYECS 292
Cdd:COG5048    21 KSTLKSLSNAprPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-300 2.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|..
gi 1149889047 279 HQRTHTGEKPYECSECGKTFIQ 300
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 289-311 1.28e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|...
gi 1149889047 289 YECSECGKTFIQKALLIKHQRIH 311
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
332-355 1.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....
gi 1149889047 332 LIKHQKSHTGEKPYECNECGKSCS 355
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-324 2.14e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 2.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1149889047 259 KPYECCECAKAFSQKSTLIAHQRTHTGEKPYECS--ECGKTFIQKALLIKHQRIHTGERPYKCCDCEK 324
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 3.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 1149889047 247 NLIVHQRIHTGEKPYECCECAKAFSQ 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-328 5.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1149889047 304 LIKHQRIHTGERPYKCCDCEKAFIR 328
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
299-368 5.48e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 5.48e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1149889047 299 IQKALLIKHQRIHTGE----RPYKCCDCEKAFIRKLTLIKHQKSHTGEKPYECN--ECGKSCSVKSSLIVHYRTHT 368
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 345-367 6.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 6.15e-03
                          10        20
                  ....*....|....*....|...
gi 1149889047 345 YECNECGKSCSVKSSLIVHYRTH 367
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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