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Conserved domains on  [gi|1149773127|ref|XP_020146129|]
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olfactory receptor 2B11 [Microcebus murinus]

Protein Classification

family 2 olfactory receptor( domain architecture ID 11610423)

family 2 olfactory receptor is a G-protein coupled receptor (GPCR) that plays a central role in olfaction, the sense of smell; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
29-298 1.46e-172

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 479.81  E-value: 1.46e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15947     1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15947   241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
 
Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
29-298 1.46e-172

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 479.81  E-value: 1.46e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15947     1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15947   241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
39-303 3.60e-44

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 153.04  E-value: 3.60e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  39 YILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGCTECVV 118
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 119 LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIKLSCADTAV 198
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 199 NDT-TLAVLVAFFVLVPLaLIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYL-----QPPSSYSQ 272
Cdd:pfam13853 165 NNIyGLFVVTSTFGIDSL-LIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrfgHNVPPLLQ 243
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1149773127 273 EQGKFISLFYSiitPTLNPFIYTLRNKDVKG 303
Cdd:pfam13853 244 IMMANAYLFFP---PVLNPIVYSVKTKQIRD 271
 
Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
29-298 1.46e-172

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 479.81  E-value: 1.46e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15947     1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15947   241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-298 3.49e-143

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 405.33  E-value: 3.49e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd13954     1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd13954    81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd13954   161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd13954   241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
31-303 4.00e-142

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 402.91  E-value: 4.00e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15434     3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15434    83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15434   163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15434   243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKG 275
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
29-303 5.21e-141

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 400.32  E-value: 5.21e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15432     1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15432   241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKE 275
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
29-303 2.98e-139

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 395.67  E-value: 2.98e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15225     1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15225    81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15225   161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15225   241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKG 275
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
29-298 1.73e-135

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 385.86  E-value: 1.73e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15237     1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15237    81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15237   161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15237   241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
30-298 1.36e-130

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 373.38  E-value: 1.36e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15230     2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15230    82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 190 KLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15230   162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241
                         250       260
                  ....*....|....*....|....*....
gi 1149773127 270 YSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15230   242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
31-303 8.55e-127

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 364.28  E-value: 8.55e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15231     3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15231    83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15231   163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15231   243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKG 275
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
30-298 1.24e-125

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 360.77  E-value: 1.24e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15431     2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVaLTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15431    82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 190 KLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15431   161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240
                         250       260
                  ....*....|....*....|....*....
gi 1149773127 270 YSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15431   241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
16-302 2.54e-124

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 358.17  E-value: 2.54e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  16 FILLGVSDRPWLELPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKT 95
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  96 ISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGR 175
Cdd:cd15408    81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 176 QVLNNFFCEVPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLF 255
Cdd:cd15408   161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 256 YLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15408   241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
31-303 4.65e-123

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 354.55  E-value: 4.65e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15421     3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15421    83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15421   163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15421   243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLG 275
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
16-302 4.63e-122

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 352.82  E-value: 4.63e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  16 FILLGVSDRPWLELPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKT 95
Cdd:cd15943     2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  96 ISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGR 175
Cdd:cd15943    82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 176 QVLNNFFCEVPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLF 255
Cdd:cd15943   162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 256 YLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15943   242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVK 288
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
31-303 7.24e-121

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 349.01  E-value: 7.24e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15429     3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15429    83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15429   163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15429   243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKG 275
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
30-304 1.63e-120

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 348.06  E-value: 1.63e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15235     3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15235    83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 190 KLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15235   163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1149773127 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGT 304
Cdd:cd15235   243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGA 277
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
16-306 1.06e-119

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 346.95  E-value: 1.06e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  16 FILLGVSDRPWLELPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKT 95
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  96 ISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGR 175
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 176 QVLNNFFCEVPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLF 255
Cdd:cd15410   161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1149773127 256 YLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGTTR 306
Cdd:cd15410   241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALR 291
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
30-302 2.03e-118

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 343.04  E-value: 2.03e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15229     2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15229    82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 190 KLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15229   162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSA 241
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15229   242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVK 274
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
29-306 8.33e-118

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 341.54  E-value: 8.33e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15417     1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15417    81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15417   161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGTTR 306
Cdd:cd15417   241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALK 278
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
31-303 3.35e-116

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 337.15  E-value: 3.35e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15433     3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15433    83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15433   163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15433   243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKG 275
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
29-298 4.05e-116

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 336.76  E-value: 4.05e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
31-304 1.14e-115

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 335.84  E-value: 1.14e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15420     3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15420    83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15420   163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGT 304
Cdd:cd15420   243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
29-306 2.31e-114

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 332.75  E-value: 2.31e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15411     1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15411    81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15411   161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGTTR 306
Cdd:cd15411   241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALR 278
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
32-298 3.67e-114

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 331.73  E-value: 3.67e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  32 FVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWL 111
Cdd:cd15227     4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 112 GCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15227    84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 192 SCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15227   164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243
                         250       260
                  ....*....|....*....|....*..
gi 1149773127 272 QEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15227   244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
29-298 7.31e-114

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 330.99  E-value: 7.31e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15911     1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15911    81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15911   161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15911   241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
31-298 2.24e-113

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 329.72  E-value: 2.24e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15430     3 LFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15430    83 MGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15430   163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242
                         250       260
                  ....*....|....*....|....*...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15430   243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
29-302 5.10e-113

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 329.27  E-value: 5.10e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15419     1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15419    81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15419   161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15419   241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVK 274
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
29-298 1.62e-112

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 327.68  E-value: 1.62e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15232   241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
29-306 6.36e-112

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 326.66  E-value: 6.36e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15412     1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15412    81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15412   161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGTTR 306
Cdd:cd15412   241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALK 278
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
31-298 1.93e-110

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 322.26  E-value: 1.93e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15918     3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15918    83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15918   163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242
                         250       260
                  ....*....|....*....|....*...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15918   243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
16-302 1.67e-107

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 315.92  E-value: 1.67e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  16 FILLGVSDRPWLELPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKT 95
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  96 ISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGR 175
Cdd:cd15945    81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 176 QVLNNFFCEVPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLF 255
Cdd:cd15945   161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 256 YLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15945   241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVK 287
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
31-303 2.81e-105

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 309.36  E-value: 2.81e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15424     3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15424    83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15424   163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15424   243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHG 275
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
31-298 1.05e-104

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 307.67  E-value: 1.05e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15224     3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15224    83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15224   163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242
                         250       260
                  ....*....|....*....|....*...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15224   243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
30-306 1.52e-104

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 307.80  E-value: 1.52e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15409     2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15409    82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 190 KLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15409   162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1149773127 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGTTR 306
Cdd:cd15409   242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALR 278
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
31-298 3.21e-104

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 306.54  E-value: 3.21e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15915     3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15915    83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRI-QSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15915   163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242
                         250       260
                  ....*....|....*....|....*....
gi 1149773127 270 YSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15915   243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
16-306 5.07e-104

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 307.10  E-value: 5.07e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  16 FILLGVSDRPWLELPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKT 95
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  96 ISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGR 175
Cdd:cd15944    81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 176 QVLNNFFCEVPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLF 255
Cdd:cd15944   161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1149773127 256 YLPAIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGTTR 306
Cdd:cd15944   241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFK 291
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
29-306 5.12e-104

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 306.22  E-value: 5.12e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15416     1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15416    81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15416   161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGTTR 306
Cdd:cd15416   241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALK 278
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
20-302 1.42e-102

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 303.14  E-value: 1.42e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  20 GVSDRPWLELPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYG 99
Cdd:cd15406     1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 100 GCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLN 179
Cdd:cd15406    81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 180 NFFCEVPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPA 259
Cdd:cd15406   161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1149773127 260 IYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15406   241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVK 283
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
30-306 7.37e-102

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 300.87  E-value: 7.37e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15415     2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15415    82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 190 KLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15415   162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1149773127 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGTTR 306
Cdd:cd15415   242 YSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALK 278
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
31-298 5.31e-101

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 298.24  E-value: 5.31e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15946     3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15946    83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15946   163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242
                         250       260
                  ....*....|....*....|....*...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15946   243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
30-303 8.36e-101

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 298.08  E-value: 8.36e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15413     2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15413    82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 190 KLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15413   162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15413   242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKD 275
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
31-298 2.23e-100

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 296.82  E-value: 2.23e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15939     3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15939    83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADT------AVNDTTLAVLVAFFVLVplaliiLSYGFITRAvLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYL 264
Cdd:cd15939   163 LACTDTyvigllVVANSGLICLLSFLILL------ISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYM 235
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 265 QPPSSYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15939   236 RPVTTFPID--KVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
29-298 7.02e-99

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 292.96  E-value: 7.02e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15226     1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15226    81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVlRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15226   161 IKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFS 239
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15226   240 TFPVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
30-303 9.95e-98

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 290.25  E-value: 9.95e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15234     2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd15234    82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 190 KLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSS 269
Cdd:cd15234   162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 270 YSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15234   242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKG 275
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
31-298 4.36e-97

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 288.45  E-value: 4.36e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15913     3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15913    83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15913   163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242
                         250       260
                  ....*....|....*....|....*...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15913   243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
29-302 5.04e-96

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 286.24  E-value: 5.04e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15414     1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15414    81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15414   161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15414   241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVK 274
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
31-303 3.78e-95

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 283.60  E-value: 3.78e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15428     3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15428    83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15428   163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15428   243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKH 275
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
29-298 1.63e-94

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 281.64  E-value: 1.63e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15940     1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15940    81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITrAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15940   161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVIL-VSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15940   240 SFSED--KVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
28-302 2.24e-94

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 282.06  E-value: 2.24e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  28 ELPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAI 107
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 108 FHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPA 187
Cdd:cd15418    81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 188 MIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPP 267
Cdd:cd15418   161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1149773127 268 SSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15418   241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVK 275
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
31-298 2.76e-94

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 281.18  E-value: 2.76e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15914     3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15914    83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15914   163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242
                         250       260
                  ....*....|....*....|....*...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15914   243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
30-302 2.83e-94

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 281.64  E-value: 2.83e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGS-SKKTISYGGCTVQYAIF 108
Cdd:cd15916     2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEpGGKVISFGGCVAQLYFF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15916    82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15916   162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 269 SYSQEqgKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15916   242 KEALD--GVIAVFYTVVTPLLNPLIYTLRNKEVK 273
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
29-298 2.39e-91

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 273.83  E-value: 2.39e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15936     1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15936    81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADT------AVNDTTLAVLVAFFVLvplaliILSYGFITRaVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYM 262
Cdd:cd15936   161 IKLACTDTfllellMVSNSGLVTLLIFFIL------LISYTVILV-KIRTHVTEGKRKALSTCASQITVVTLIFVPCIYI 233
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1149773127 263 YLQPPSSYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15936   234 YARPFQTFPMD--KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
29-302 2.12e-90

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 271.60  E-value: 2.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15405     1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15405    81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15405   161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15405   241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVK 274
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
29-302 2.85e-89

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 268.90  E-value: 2.85e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15407     1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15407    81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15407   161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 269 SYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15407   241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVK 274
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
31-303 1.06e-87

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 264.73  E-value: 1.06e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15233     3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15233    83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15233   163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15233   243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKG 275
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
31-303 2.55e-87

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 263.91  E-value: 2.55e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15228     3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15228    83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPpsSY 270
Cdd:cd15228   163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQP--TP 240
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 271 SQEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15228   241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKA 273
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
29-302 6.85e-86

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 260.06  E-value: 6.85e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15942     1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15942    81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15942   161 LKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 269 SYSqeQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15942   241 QDP--LDGVVAVFYTTVTPLLNPVIYTLRNKEMK 272
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
32-303 7.41e-86

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 260.09  E-value: 7.41e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  32 FVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWL 111
Cdd:cd15236     4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 112 GCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15236    84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 192 SCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSYS 271
Cdd:cd15236   164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1149773127 272 QEQGKFISLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15236   244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKG 275
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
29-298 2.43e-85

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 258.51  E-value: 2.43e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15937     1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15937    81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITrAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15937   161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFR 239
                         250       260       270
                  ....*....|....*....|....*....|
gi 1149773127 269 SYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15937   240 SFPMD--KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
31-298 1.04e-84

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 256.72  E-value: 1.04e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15938     3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15938    83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFItraVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSY 270
Cdd:cd15938   163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239
                         250       260
                  ....*....|....*....|....*...
gi 1149773127 271 SQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15938   240 PVD--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
31-302 1.07e-83

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 254.77  E-value: 1.07e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQS-PMYIFLSHLSFLDLCYTATTVPQMLVNM-GSSKKTISYGGCTVQYAIF 108
Cdd:cd15941     3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLlTLSGRTISFEGCVVQLYAF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAM 188
Cdd:cd15941    83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15941   163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 269 sySQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15941   243 --SQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVK 274
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
29-298 4.78e-83

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 252.76  E-value: 4.78e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQL-QSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAI 107
Cdd:cd15935     1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 108 FHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPA 187
Cdd:cd15935    81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 188 MIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITrAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQPP 267
Cdd:cd15935   161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIIL-TTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPF 239
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1149773127 268 SSYSQEqgKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15935   240 SSSSVD--KVASVFYTLITPALNPLIYTLRN 268
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
25-302 8.00e-71

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 221.78  E-value: 8.00e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  25 PWLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQ 104
Cdd:cd15223     1 HWLSLPFLLL----YLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 105 YAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCE 184
Cdd:cd15223    77 MFFIHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCD 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 185 VPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYL 264
Cdd:cd15223   157 HMALVSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSL 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1149773127 265 --QPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15223   237 tyRFGKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIR 276
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
39-301 2.65e-64

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 204.96  E-value: 2.65e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  39 YILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGCTECVV 118
Cdd:cd15950    11 YVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 119 LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFgnsLVQVALTVQ---LPFCGRQVLNNFFCEVPAMIKLSCAD 195
Cdd:cd15950    91 LLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRAL---LFMTPLTCLvtsLPYCGSRVVPHSYCEHMAVVKLACAD 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 196 TAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIY-MYLQppsSYSQEQ 274
Cdd:cd15950   168 PRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQ---RFGQGV 244
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1149773127 275 GKFISL----FYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15950   245 PPHTQVlladLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
26-299 1.27e-62

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 200.59  E-value: 1.27e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQY 105
Cdd:cd15917     2 WLSIPFCAM----YLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVmhraLCQQLVAAAWLSGFGNSLVQVA----LTVQLPFCGRQVLNNF 181
Cdd:cd15917    78 FFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTI----LTNTVVGKIGLAILLRAVALIIplplLVRRLPYCGSNVISHS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 182 FCEVPAMIKLSCADTAVNdTTLAVLVAFFVLV-PLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAI 260
Cdd:cd15917   154 YCEHMAVVKLACGDTRVN-SIYGLFVALLIVGfDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPAL 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 261 YmylqppSSYSQEQGK--------FISLFYSIITPTLNPFIYTLRNK 299
Cdd:cd15917   233 F------SFLTHRFGHhvpphvhiLLANLYLLLPPMLNPIVYGVRTK 273
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
26-299 5.23e-61

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 196.36  E-value: 5.23e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQY 105
Cdd:cd15221     2 WISIPFCSM----YIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15221    78 FFVHFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 186 PAMIKLSCADTAVNdTTLAVLVAFFVLV-PLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYL 264
Cdd:cd15221   158 MGIARLACADITVN-IWYGLTVALLTVGlDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFL 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1149773127 265 qppssySQEQGKFISL--------FYSIITPTLNPFIYTLRNK 299
Cdd:cd15221   237 ------THRFGRHIPRhvhillanLYVLVPPMLNPIVYGVKTK 273
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
26-301 1.51e-59

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 192.60  E-value: 1.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQY 105
Cdd:cd15952     2 WIGFPFCAV----YLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVmhraLCQQLVAAAWLSGFGNSLVQVA----LTVQLPFCGRQVLNNF 181
Cdd:cd15952    78 FFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTI----LTNKVISVIALGIVLRPLLLVLpfvfLILRLPFCGHNIIPHT 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 182 FCEVPAMIKLSCADTAVNDTTLAVLVAFFVLvPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIY 261
Cdd:cd15952   154 YCEHMGIAKLACASIRINIIYGLFAISVLVL-DVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALF 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1149773127 262 MYLQppSSYSQEQGKFISL----FYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15952   233 SFLT--HRFGHNIPRYIHIllanLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
26-299 8.30e-59

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 190.55  E-value: 8.30e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVvllvFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQY 105
Cdd:cd15953     2 WISIPFCL----MYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15953    78 FFIHTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 186 PAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQ 265
Cdd:cd15953   158 MAVVKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLT 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1149773127 266 -------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNK 299
Cdd:cd15953   238 hrfgqgiAPHIHI-----ILANLYLLVPPMLNPIIYGVKTK 273
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
26-301 1.37e-57

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 187.55  E-value: 1.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQY 105
Cdd:cd15951     2 WISIPFCIM----YAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15951    78 FFIHSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 186 PAMIKLSCADTAVNdTTLAVLVAFFVL-VPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYL 264
Cdd:cd15951   158 MAVVKLACADTRVS-RAYGLSVAFLVGgLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFL 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1149773127 265 Q-------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15951   237 ThrfghnvPPHVHI-----LIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
25-299 3.09e-57

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 186.55  E-value: 3.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  25 PWLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQ 104
Cdd:cd15222     1 HWISIPFCLL----YLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 105 YAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCE 184
Cdd:cd15222    77 MFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 185 VPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAI---- 260
Cdd:cd15222   157 HQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIglsm 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1149773127 261 -YMYLQPPSSYSQeqgKFISLFYSIITPTLNPFIYTLRNK 299
Cdd:cd15222   237 vHRFGKHASPLVH---VLMANVYLLVPPVLNPIIYSVKTK 273
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
25-302 8.00e-52

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 172.78  E-value: 8.00e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  25 PWLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQ 104
Cdd:cd15948     2 PWISIPFCSA----FTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 105 YAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCE 184
Cdd:cd15948    78 MFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 185 VPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYmyl 264
Cdd:cd15948   158 HMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVL--- 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1149773127 265 qppSSYSQEQGK--------FISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15948   235 ---SSTMHRFARhvaphvhiLLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
13-302 1.18e-45

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 157.25  E-value: 1.18e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  13 PQHFILLGVSDRPWLELPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSS 92
Cdd:cd15949     1 PSTFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  93 KKTISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPF 172
Cdd:cd15949    81 SNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 173 CGRQVLNNFFCEVPAMIKLSCADTAVNDtTLAVLVAFFVLVPLAL-IILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVV 251
Cdd:cd15949   161 YRTNIIAHSYCEHMAVVGLACGDVSINN-HYGLTIGFLVLIMDSLfIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCA 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1149773127 252 VSLFYLPAIYMYLQ-------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15949   240 ILAFYVPIAVSSLIhrfgqnvPPPTHI-----LLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
26-301 6.64e-45

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 154.64  E-value: 6.64e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQY 105
Cdd:cd15956     2 WLSLPFCFI----YVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15956    78 FLVHAFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 186 PAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYLQ 265
Cdd:cd15956   158 MAVVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLM 237
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1149773127 266 PPSSYSQEQGKFISL--FYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15956   238 HRFGHSVPSAAHVLLsnLYLLLPPALNPIVYGIRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
39-303 3.60e-44

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 153.04  E-value: 3.60e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  39 YILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGCTECVV 118
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 119 LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIKLSCADTAV 198
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 199 NDT-TLAVLVAFFVLVPLaLIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMYL-----QPPSSYSQ 272
Cdd:pfam13853 165 NNIyGLFVVTSTFGIDSL-LIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrfgHNVPPLLQ 243
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1149773127 273 EQGKFISLFYSiitPTLNPFIYTLRNKDVKG 303
Cdd:pfam13853 244 IMMANAYLFFP---PVLNPIVYSVKTKQIRD 271
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
45-294 3.39e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 141.67  E-value: 3.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  45 GNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLV-NMGSSKKTISYGGCTVQYAIFHWLGCTECVVLAAMA 123
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 124 LDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRqvlNNFFCEVPAMIKLSCadtavnDTTL 203
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSK------PVSY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 204 AVLVAFFV-LVPLALIILSYGFITRAVLRIQSSKGR-------RKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSYSQEQG 275
Cdd:pfam00001 152 TLLISVLGfLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELS 231
                         250       260
                  ....*....|....*....|....*
gi 1149773127 276 KFISLFYSII------TPTLNPFIY 294
Cdd:pfam00001 232 RLLDKALSVTlwlayvNSCLNPIIY 256
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
26-301 5.54e-39

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 139.13  E-value: 5.54e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQY 105
Cdd:cd15955     2 WIGIPFCIM----FLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAA-----VMHRALCQQLVAAAWLSGFGNSLVQVALTvqlpFCGRQVLNN 180
Cdd:cd15955    78 FFIHTLQAFESGILLAMALDRYVAICHPLRHSSiltpqVLLGIGVLVVVRAVVLIIPCPLLIKLRLH----HFRSTVISH 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 181 FFCEVPAMIKLSCADTAVNdTTLAVLVAFFVL-VPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPA 259
Cdd:cd15955   154 SYCEHMAVVKLAADDVRVN-KIYGLFVAFSILgFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLA 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1149773127 260 IYMYLQ-------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15955   233 FFSFFAhrfghhvAPYVHI-----LLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
26-301 1.47e-38

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 138.03  E-value: 1.47e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVllvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQY 105
Cdd:cd15954     2 WISIPFCFM----YIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 AIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEV 185
Cdd:cd15954    78 FFVHTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 186 PAMIKLSCADTAVNDT---TLAVLVAFFvlvPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYM 262
Cdd:cd15954   158 MSVVKLACANIRVDAIyglMVALLIGGF---DILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFT 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 263 YLQ--------PPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDV 301
Cdd:cd15954   235 FFAhrfgghhiTPHIHI-----IMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
31-298 7.56e-30

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 115.08  E-value: 7.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LScadtavndttlAVLVAFFVLVPLALIILSYGFITRAVLR--------------IQSSKGRRKAFGTCSSHLVVVSLFY 256
Cdd:cd00637   161 YT-----------IFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTLLIVVVVFLLCW 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1149773127 257 LP----AIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd00637   230 LPyfilLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
33-300 2.91e-16

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 77.63  E-value: 2.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYAIFH-WL 111
Cdd:cd14969     5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVI-YGFAVtFL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 112 GCTECVVLAAMALDRYVAICEPLRYAAV-MHRALCqqLVAAAWLSGFGNSLvqvaltvqLPFCGrqvLNNFfceVPAMIK 190
Cdd:cd14969    84 GLVSISTLAALAFERYLVIVRPLKAFRLsKRRALI--LIAFIWLYGLFWAL--------PPLFG---WSSY---VPEGGG 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCA-----DTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAV----------LRIQSSKGRRKAFGTCSSHLVVVSLF 255
Cdd:cd14969   148 TSCSvdwysKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLrkmskraarrKNSAITKRTKKAEKKVAKMVLVMIVA 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 256 YL----P----AIYMYLQPPSSysqeqgkfISLFYSIITPTL-------NPFIYTLRNKD 300
Cdd:cd14969   228 FLiawtPyavvSLYVSFGGEST--------IPPLLATIPALFaksstiyNPIIYVFMNKQ 279
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
31-302 2.04e-15

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 74.91  E-value: 2.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd14967     2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLPfcgRQVLNNFFCEVPAMIK 190
Cdd:cd14967    82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWV---------YSLLISLP---PLVGWRDETQPSVVDC 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFvlVPLALIILSYGFITRAVLRiqsskgRRKAFGTCSshlVVVSLFY---LPAIYMYL--- 264
Cdd:cd14967   150 ECEFTPNKIYVLVSSVISFF--IPLLIMIVLYARIFRVARR------ELKAAKTLA---IIVGAFLlcwLPFFIIYLvsa 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1149773127 265 -QPPSSYSQEqgkFISLFYSI--ITPTLNPFIYTLRNKDVK 302
Cdd:cd14967   219 fCPPDCVPPI---LYAVFFWLgyLNSALNPIIYALFNRDFR 256
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
33-231 6.41e-12

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 65.05  E-value: 6.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLG 112
Cdd:cd15083     5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVqvaltvqlPFCGrqvLNNFfceVPAMIKLS 192
Cdd:cd15083    85 IMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP--------PLFG---WSRY---VLEGLLTS 150
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1149773127 193 C-----ADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLR 231
Cdd:cd15083   151 CsfdylSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRR 194
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
29-304 1.31e-11

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 64.20  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVP-QMLVNMGsskKTISYGGCTV---- 103
Cdd:cd14968     1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPlAILISLG---LPTNFHGCLFmacl 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 104 -----QYAIFHwlgctecvvLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGnslvqVALTvqlPFCGrqvL 178
Cdd:cd14968    78 vlvltQSSIFS---------LLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFL-----VGLT---PMFG---W 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 179 NNFFCEVPAMIK--LSCADTAVNDTTLAVLVAFF--VLVPLALIILSYGFITRAVLR-------IQSSKGRRKAFG---- 243
Cdd:cd14968   138 NNGAPLESGCGEggIQCLFEEVIPMDYMVYFNFFacVLVPLLIMLVIYLRIFRVIRKqlrqiesLLRSRRSRSTLQkevk 217
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1149773127 244 TCSSHLVVVSLFYLPAIYMY------LQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGT 304
Cdd:cd14968   218 AAKSLAIILFLFALCWLPLHiincitLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQT 284
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
26-299 1.50e-10

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 60.87  E-value: 1.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVLlvfYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDL-----CYTATTVPQMLVNMgsskktisYGG 100
Cdd:cd15206     1 ELIIPLYSVI---FLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLllavfCMPFTLVGQLLRNF--------IFG 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 101 CTVQYAIFHWLGCTECV---VLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFgnslvqvalTVQLPFCGRQV 177
Cdd:cd15206    70 EVMCKLIPYFQAVSVSVstfTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSF---------LIMSPILVFSN 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 178 LNNFFCEVPAMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLriQSSKGRRKAFgtcsshLVVVSLFYL 257
Cdd:cd15206   141 LIPMSRPGGHKCREVWPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL--EAKKRVIRML------FVIVVEFFI 212
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1149773127 258 PAIYMY-------LQPPSSYSQEQGKFISLFY--SIITPTLNPFIYTLRNK 299
Cdd:cd15206   213 CWTPLYvintwkaFDPPSAARYVSSTTISLIQllAYISSCVNPITYCFMNK 263
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
31-236 1.91e-10

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 60.67  E-value: 1.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTvPQMLVNMGSSKKTISYGGCTVqYAIFHW 110
Cdd:cd15079     3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGCQI-YAFLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 L-GCTECVVLAAMALDRYVAICEPLRyAAVMHRALCQQLVAAAWLSGFGNSLvqvaltvqLPFCGrqVLNNFfceVPAMI 189
Cdd:cd15079    81 LsGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWAL--------LPLLF--GWGRY---VPEGF 146
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1149773127 190 KLSCADTAVNDTTLAV--LVAFFV---LVPLALIILSYGFITRAV------LRIQSSK 236
Cdd:cd15079   147 LTSCSFDYLTRDWNTRsfVATIFVfayVIPLIIIIYCYSFIVKAVfahekaLREQAKK 204
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
33-299 2.66e-10

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 60.30  E-value: 2.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVN-MGSSKKTISYGGCTVQYAIFHWL 111
Cdd:cd15305     5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAiLYDYAWPLPRYLCPIWISLDVLF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 112 GCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWlsgfgnsLVQVALTVQLPFCGRQVLNNFFcevpamIKL 191
Cdd:cd15305    85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW-------TISIGISMPIPVIGLQDDEKVF------VNG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 192 SCADTAVNDTTLAVLVAFFvlVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSS----HLVVVSLFYLPAIYMYLQPP 267
Cdd:cd15305   152 TCVLNDENFVLIGSFVAFF--IPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIvfflFLIMWCPFFITNILSVLCKE 229
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 268 SSYSQEQGKFISLFYSI--ITPTLNPFIYTLRNK 299
Cdd:cd15305   230 ACDQKLMEELLNVFVWVgyVSSGINPLVYTLFNK 263
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
33-231 9.71e-10

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 58.40  E-value: 9.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLcytATTVPQMLVNMGSSKKTISYGG---CT-VQYA-I 107
Cdd:cd15196     5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADL---LVALFNVLPQLIWDITYRFYGGdllCRlVKYLqV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 108 FHWLGCTecVVLAAMALDRYVAICEPLRYAAVmHRALCQQLVAAAWLSGFGNSLVQVALtVQLPFCGRQVLNnffcevpa 187
Cdd:cd15196    82 VGMYASS--YVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQLFI-FSYQEVGSGVYD-------- 149
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1149773127 188 miklsCADTAVNDTTLAVLVAFFV----LVPLALIILSYGFITRAVLR 231
Cdd:cd15196   150 -----CWATFEPPWGLRAYITWFTvavfVVPLIILAFCYGRICYVVWR 192
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
30-299 2.66e-09

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 57.07  E-value: 2.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15012     1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLP-FCGRQVLNNFFCEVPAM 188
Cdd:cd15012    81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWL---------TSAVYNTPyFVFSQTVEILVTQDGQE 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFV--LVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLP--AIYMYl 264
Cdd:cd15012   152 EEICVLDREMFNSKLYDTINFIVwyLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNLPyhARKMW- 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1149773127 265 qppsSYSQEQGKFISLFYSIITP----------TLNPFIYTLRNK 299
Cdd:cd15012   231 ----QYWSEPYRCDSNWNALLTPltflvlyfnsAVNPLLYAFLSK 271
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
35-299 3.52e-09

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 57.05  E-value: 3.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  35 LLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGCT 114
Cdd:cd15073     7 LIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 115 ECVVLAAMALDRYVAICEPLRYAAVMHRALCqQLVAAAWLSGFGNSLvqvaltvqLPFCGRQVLNNFFCEVPAMIKLSCA 194
Cdd:cd15073    87 SIGLLTVVAVDRYLTICRPDLGRKMTTNTYT-VMILLAWTNAFFWAA--------MPLVGWASYALDPTGATCTINWRKN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 195 DTAVNDTTLAVLVAFFVlVPLALIILSYGFITRAVlriqsskgRRKAFGTCSSHLVV-------VSLFYLPAIYMYLQPP 267
Cdd:cd15073   158 DSSFVSYTMSVIVVNFI-VPLAVMFYCYYNVSRFV--------KKVLASDCLESVNIdwtdqndVTKMSVIMIVMFLVAW 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 268 SSYS--------QEQGKfISLFYSIITPTL-------NPFIYTLRNK 299
Cdd:cd15073   229 SPYSivclwasfGEPKK-IPPWMAIIPPLFaksstfyNPCIYVIANK 274
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
33-299 8.96e-09

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 55.71  E-value: 8.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVP-QMLVNMGSSKKTISYGGCTVQYAIFHWL 111
Cdd:cd15304     5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 112 GCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWlsgfgnsLVQVALTVQLPFCGRQVLNNFFCEVpamikl 191
Cdd:cd15304    85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW-------TISVGISMPIPVFGLQDDSKVFKEG------ 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 192 SCADTAVNDTTLAVLVAFFvlVPLALIILSYGFITRAVLR-IQSSKGRRKAFGTCSSHLVVV-SLFYLPAIYMYLQPPSS 269
Cdd:cd15304   152 SCLLADENFVLIGSFVAFF--IPLTIMVITYFLTIKSLQQsISNEQKASKVLGIVFFLFVVMwCPFFITNVMAVICKESC 229
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1149773127 270 YSQEQGKFISLFYSI--ITPTLNPFIYTLRNK 299
Cdd:cd15304   230 NEVVIGGLLNVFVWIgyLSSAVNPLVYTLFNK 261
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
31-304 1.06e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 55.71  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVL-LVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLvnmgsskkTISYGGCTVQYAIFh 109
Cdd:cd15069     2 TYVALeLIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--------TISLGFCTDFHSCL- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVV-------LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGnslvqVALTVQLPFCGRQVLNNfF 182
Cdd:cd15069    73 FLACFVLVLtqssifsLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFG-----IGLTPFLGWNKAMSATN-N 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 183 CEVPA-------MIKLSCADTAVNDTTLAVLVAFF--VLVPLALIILSYGFI--------TRAVLRIQSSKGRRKAFGTC 245
Cdd:cd15069   147 STNPAdhgtnhsCCLISCLFENVVPMSYMVYFNFFgcVLPPLLIMLVIYIKIflvacrqlQRTELMDHSRTTLQREIHAA 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1149773127 246 SSHLVVVSLFYLPAIYMY-LQPPSSYSQEQGK-------FISLFYSIITPTLNPFIYTLRNKDVKGT 304
Cdd:cd15069   227 KSLAIIVGIFALCWLPVHiLNCITLFQPEFSKskpkwamNVAILLSHANSVVNPIVYAYRNRDFRYT 293
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
34-239 1.22e-08

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 55.46  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTV-PQ---------MLVNMGSskKTISYGGCTV 103
Cdd:cd14986     6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVlTQiiweatgewVAGDVLC--RIVKYLQVVG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 104 QYAifhwlgctECVVLAAMALDRYVAICEPLRYAAvmHRALCQQLVAAAWLSGFGNSLVQVALTVQlpfcgRQVLNNFFc 183
Cdd:cd14986    84 LFA--------STYILVSMSLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLVIFVE-----RELGDGVH- 147
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 184 evpamiklSCADTAVNDTTLAVLV---AFFVLV-PLALIILSYGFITRAVLRIQSSKGRR 239
Cdd:cd14986   148 --------QCWSSFYTPWQRKVYItwlATYVFViPLIILSYCYGRILRTIWIRSRQKTDR 199
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
34-229 1.69e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 55.11  E-value: 1.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGC 113
Cdd:cd15336     6 VILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 114 TECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVqvaltvqlPFCGrqvlnnFFCEVPAMIKLSC 193
Cdd:cd15336    86 TSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLP--------PLFG------WSAYVPEGLLTSC 151
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1149773127 194 A-----DTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAV 229
Cdd:cd15336   152 TwdymtFTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAI 192
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
33-299 2.78e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 54.14  E-value: 2.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFY----ILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVP-QMLVNMGSSK-------KTISY-G 99
Cdd:cd14993     1 IVLIVLYvvvfLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRPWvfgevlcKAVPYlQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 100 GCTVqyaifhwlgCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLPF-CGRQVL 178
Cdd:cd14993    81 GVSV---------SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWV---------IAIIIMLPLlVVYELE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 179 NNFFCEVPAMIKLSCADTAVNDT-----TLAVLVAFFVlVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSH----- 248
Cdd:cd14993   143 EIISSEPGTITIYICTEDWPSPElrkayNVALFVVLYV-LPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRilrsk 221
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1149773127 249 -------LVVVSLF-------YLPAIYMYLQPPSS-YSQEQGKFISLF---YSIITPTLNPFIYTLRNK 299
Cdd:cd14993   222 kkvarmlIVVVVLFalswlpyYVLSILLDFGPLSSeESDENFLLILPFaqlLGYSNSAINPIIYCFMSK 290
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
31-300 3.14e-08

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 53.90  E-value: 3.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMgsSKKTISYGGCTVQYAI-FH 109
Cdd:cd15061     2 LISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQ--LLGYWPLGSHLCDFWIsLD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFgnslvqvaLTVQLPFCGrqvlnnFFCEVPAM 188
Cdd:cd15061    80 VLLCTASILnLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISL--------LITSPPLVG------PSWHGRRG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFvlVPLALIILSYGFITRAVLRiqsskgRRKAFGTCSshlVVVSLF---YLPAIYMYLQ 265
Cdd:cd15061   146 LGSCYYTYDKGYRIYSSMGSFF--LPLLLMLFVYLRIFRVIAK------ERKTAKTLA---IVVGCFivcWLPFFIMYLI 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1149773127 266 PP---SSYSQEQGKFIS---LFYSIItptlNPFIYTLRNKD 300
Cdd:cd15061   215 EPfcdCQFSEALSTAFTwlgYFNSVI----NPFIYAFYNKD 251
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
30-296 3.96e-08

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 53.90  E-value: 3.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKK-TISYGGCTVQYAIF 108
Cdd:cd14979     2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwAFGDGGCKLYYFLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HwlGCTECVVL--AAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLPFC---GRQVLNNFFC 183
Cdd:cd14979    82 E--ACTYATVLtiVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWL---------VSILCAIPILflmGIQYLNGPLP 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 184 EVP---AMIKLSCADTAVNDTTLAVLVAFFVLvPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHL----------- 249
Cdd:cd14979   151 GPVpdsAVCTLVVDRSTFKYVFQVSTFIFFVL-PMFVISILYFRIGVKLRSMRNIKKGTRAQGTRNVELslsqqarrqvv 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1149773127 250 ----VVVSLF---YLPaiYMYLQPPSSYSQEQGKFISLFYSIITP----------TLNPFIYTL 296
Cdd:cd14979   230 kmlgAVVIAFfvcWLP--FHAQRLMFSYASKEDTFLFDFYQYLYPisgilfylssAINPILYNL 291
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
30-231 6.29e-08

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 53.26  E-value: 6.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLcYTATTVPQMLVNMGSSKKTIsYGGCTVQYAIFH 109
Cdd:cd15928     2 AVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLWRYRPWR-FGDLLCRLMYFF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVL--AAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGF---GNSLVQVALTvQLPfcGRQVLNNFfce 184
Cdd:cd15928    80 SETCTYASILhiTALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIvsaGPALVLVGVE-HIQ--GQQTPRGF--- 153
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1149773127 185 vpamiklSCADTAVNDTTLAVLV---AFFVLVPLALIILSYGFITRAVLR 231
Cdd:cd15928   154 -------ECTVVNVSSGLLSVMLwvsTSFFFVPMVCLSLLYGLIGRALWD 196
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
30-157 8.30e-08

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 52.66  E-value: 8.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGC-TVQYAIF 108
Cdd:cd15001     1 PVIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCkAVAYLQL 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1149773127 109 HWLGCTeCVVLAAMALDRYVAICEPL--RYAAVMHRALcqQLVAAAWLSGF 157
Cdd:cd15001    81 LSFICS-VLTLTAISIERYYVILHPMkaKSFCTIGRAR--KVALLIWILSA 128
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
37-299 1.10e-07

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 52.51  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  37 VFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDL-----CYTATTVPQMLVNM----GSSKKTISYGGCTVQYAI 107
Cdd:cd15979     9 VIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmlavfCMPFTLIPNLMGTFifgeVICKAVAYLMGVSVSVST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 108 FHwlgctecvvLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFgnsLVQV-----ALTVQLPFCGRQVLNnff 182
Cdd:cd15979    89 FS---------LVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSG---LIMIpypvySVTVPVPVGDRPRGH--- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 183 cevpaMIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRrkafgTCSSHLVVVSLFYLPAIYM 262
Cdd:cd15979   154 -----QCRHAWPSAQVRQAWYVLLLLILFFIPGVVMIVAYGLISRELYRGLLAKKR-----VIRMLVVIVAMFFLCWLPI 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1149773127 263 Y-------LQPPSSYSQEQGKFISLFY--SIITPTLNPFIYTLRNK 299
Cdd:cd15979   224 FsantwraFDPLSAHRALSGAPISFIHllSYTSACVNPLVYCFMNR 269
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
32-302 1.36e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 52.11  E-value: 1.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  32 FVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWL 111
Cdd:cd15063     4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 112 GCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFgnslvqvaLTVQLPFCGRQVLNNFFCEVPAMIKL 191
Cdd:cd15063    84 CTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSF--------VICFPPLVGWNDGKDGIMDYSGSSSL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 192 SCADTAVND---TTLAVLVAFFvlVPLALIILSYGFITRAVLRiqsskgRRKAFGTCSshlVVVSLF---YLPAIYMYLQ 265
Cdd:cd15063   156 PCTCELTNGrgyVIYSALGSFY--IPMLVMLFFYFRIYRAARM------ETKAAKTVA---IIVGCFifcWLPFFTVYLV 224
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1149773127 266 PPSSYSQEQGKFISLFYSI--ITPTLNPFIYTLRNKDVK 302
Cdd:cd15063   225 RAFCEDCIPPLLFSVFFWLgyCNSALNPCIYALFSRDFR 263
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-247 2.21e-07

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 51.74  E-value: 2.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTV-PQMLVNMgsskkTISYGGCTVQYAIFHWLG 112
Cdd:cd15387     6 VLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVlPQLIWDI-----TFRFYGPDFLCRLVKYLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 C----TECVVLAAMALDRYVAICEPLRyaaVMHRALCQQLVAAAWLSGFGNSLVQVALtvqlpFCGRQVLNNFFCEVPAM 188
Cdd:cd15387    81 VvgmfASTYMLLLMSIDRCLAICQPLR---SLHRRSDRVYVLFSWLLSLVFSIPQVHI-----FSLREVGNGVYDCWADF 152
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1149773127 189 IKLSCADTAVNDTTLAVLVaffvlVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSS 247
Cdd:cd15387   153 IQPWGPKAYITWITLSVYI-----IPVLILSVCYGLISFKIWQNVKLKTRRETKTPLSS 206
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
34-243 5.83e-07

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 50.18  E-value: 5.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIIL-VSRLDPQLqSPMYIFLSHLSFLDLCYTATTV-PQMLVNMgsskkTISYGG----C-TVQYa 106
Cdd:cd15386     6 VLAAILVVATAGNLAVLLaMYRMRRKM-SRMHLFVLHLALTDLVVALFQVlPQLIWEI-----TYRFQGpdllCrAVKY- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 107 iFHWLGC-TECVVLAAMALDRYVAICEPLRYAAVMHRALCqQLVAAAWLSGFGNSLVQVALtvqlpFCGRQVlnnffceV 185
Cdd:cd15386    79 -LQVLSMfASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAY-LMIGATWLLSCILSLPQVFI-----FSLREV-------D 144
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 186 PAMIKLSC---------ADTAVNDTTLAVLVaffvlVPLALIILSYGFITRAV---LRIQSSKGRRKAFG 243
Cdd:cd15386   145 QGSGVLDCwadfgfpwgAKAYITWTTLSIFV-----LPVAILIVCYSLICYEIcknLKGKTQTSRSEGGG 209
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
33-304 7.37e-07

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 49.94  E-value: 7.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVnmgsskktISYGGCTVQYAIFhWLG 112
Cdd:cd15068     5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--------ISTGFCAACHGCL-FIA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVV-------LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGnslvqVALTVQLPF--CGRQVLNNFFC 183
Cdd:cd15068    76 CFVLVLtqssifsLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFA-----IGLTPMLGWnnCGQPKEGKNHS 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 184 EVPAMIKLSCADTAVNDTTLAVLVAFF--VLVPLALIILSYGFITRAVLR------------IQSSKGRRKAFGTCSSHL 249
Cdd:cd15068   151 QGCGEGQVACLFEDVVPMNYMVYFNFFacVLVPLLLMLGVYLRIFLAARRqlkqmesqplpgERARSTLQKEVHAAKSLA 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1149773127 250 VVVSLF---YLPA----IYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGT 304
Cdd:cd15068   231 IIVGLFalcWLPLhiinCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQT 292
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
31-302 7.97e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 49.62  E-value: 7.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFyiLAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVP-QMLVNMGSSKKTISYGGCTVqYAIFH 109
Cdd:cd15052     5 LLLLLLVI--ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLL-WVTLD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWlsgfgnsLVQVALTVQLPFCGRQVLNNFFCEvpam 188
Cdd:cd15052    82 VLFCTASIMhLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVW-------LISIGISSPIPVLGIIDTTNVLNN---- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 ikLSCADTAVNDTTLAVLVAFFvlVPLALIILSYGFITRAVLRiqsskgRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPS 268
Cdd:cd15052   151 --GTCVLFNPNFVIYGSIVAFF--IPLLIMVVTYALTIRLLSN------EQKASKVLGIVFAVFVICWCPFFITNILTGL 220
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1149773127 269 SYSQEQ---GKFISLFYSI--ITPTLNPFIYTLRNKDVK 302
Cdd:cd15052   221 CEECNCrisPWLLSVFVWLgyVSSTINPIIYTIFNKTFR 259
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
33-299 1.14e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 49.20  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYAIFHWL- 111
Cdd:cd15074     5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVF-YGFCGFLf 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 112 GCTECVVLAAMALDRYVAICEPlRYAAVMHRALCQQLVAAAWLSGFGNSLvqvaltvqLPFCGrqvLNNFfceVPAMIKL 191
Cdd:cd15074    84 GCCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAV--------APLVG---WGSY---GPEPFGT 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 192 SC------ADTAVNDTTLAVLVAFFV-LVPLALIILSYGFITRAVlriQSSKGRRKAFGTCSSHL-----------VVVS 253
Cdd:cd15074   149 SCsidwtgASASVGGMSYIISIFIFCyLLPVLIIVFSYVKIIRKV---KSSRKRVAGFDSRSKRQhkierkvtkvaVLIC 225
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 254 LFYLPA------IYMYlqppSSYSQEQGKFISLFysiITPTL--------NPFIYTLRNK 299
Cdd:cd15074   226 AGFLIAwtpyavVSMW----SAFGSPDSVPILAS---ILPALfaksscmyNPIIYLLFSS 278
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
42-302 1.67e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 48.82  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  42 AMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYAIFHWLGCTECVV-LA 120
Cdd:cd15330    14 AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDL-FIALDVLCCTSSILhLC 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 121 AMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSlvqvaltvqlpfcgrqvlnnffceVPAMIKLSCADTAVND 200
Cdd:cd15330    93 AIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSIS------------------------IPPMLGWRTPEDRSDP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 201 -----------TTLAVLVAFFvlVPLALIILSYGFITRAVLRiqsskgRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPss 269
Cdd:cd15330   149 dactiskdpgyTIYSTFGAFY--IPLILMLVLYGRIFKAAAR------ERKTVKTLGIIMGTFILCWLPFFIVALVLP-- 218
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1149773127 270 YSQEQGKFISLFYSIIT------PTLNPFIYTLRNKDVK 302
Cdd:cd15330   219 FCESTCHMPELLGAIINwlgysnSLLNPIIYAYFNKDFQ 257
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
30-154 2.46e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.60  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILA-MLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIf 108
Cdd:cd15058     1 PGLLLLLALIILAiVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSV- 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 109 HWLGCTECV-VLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWL 154
Cdd:cd15058    80 DVLCVTASIeTLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWI 126
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
32-229 3.01e-06

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 48.19  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  32 FVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSK--------KTISYGGCTV 103
Cdd:cd15197     4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEwragdfacKVIRYLQVVV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 104 QYAifhwlgctECVVLAAMALDRYVAICEPLRYAAVMHRAlcQQLVAAAWLSGFGNSLVQVALtvqlpFCGRQVLNNffc 183
Cdd:cd15197    84 TYA--------STYVLVALSIDRYDAICHPMNFSQSGRQA--RVLICVAWILSALFSIPMLII-----FEKTGLSNG--- 145
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 184 EVPAMIKL-SCADTAVNDTTLAVLVAFfvlVPLALIILSYGFITRAV 229
Cdd:cd15197   146 EVQCWILWpEPWYWKVYMTIVAFLVFF---IPATIISICYIIIVRTI 189
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
40-229 4.06e-06

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 47.70  E-value: 4.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  40 ILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATtvpqmlvnMGSSKKTISyggCTVQYAIFHWLGC------ 113
Cdd:cd15337    12 ILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAV--------NGFPLKTIS---SFNKKWIWGKVACelygfa 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 114 ------TECVVLAAMALDRYVAICEPLRYAAVM--HRALCQQLVAAAWlsgfgnslvqVALTVQLPFC--GRQVLNNFFC 183
Cdd:cd15337    81 ggifgfMSITTLAAISIDRYLVIAKPLEAMKKMtfKRAFIMIIIIWLW----------SLLWSIPPFFgwGRYVPEGFQT 150
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1149773127 184 evpamiklSCA-----DTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAV 229
Cdd:cd15337   151 --------SCTfdylsRDLNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAV 193
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
33-239 4.54e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 47.67  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAML----GNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSK-----KTISYGGCTV 103
Cdd:cd14997     1 VLVSVVYGVIFVvgvlGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREpwllgEFMCKLVPFV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 104 QYAIFHwlgcTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQL---PFCGRQVlnn 180
Cdd:cd14997    81 ELTVAH----ASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKeedFNDGTPV--- 153
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1149773127 181 FFCEVPAmiklscADTAVNDTTLAVLVAFFVlVPLALIILSYGFITRAVLRIQSSKGRR 239
Cdd:cd14997   154 AVCRTPA------DTFWKVAYILSTIVVFFV-VPLAILSGLYSVICRRLVGHPALESRR 205
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
31-167 5.55e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 47.07  E-value: 5.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMY-IFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15219     2 LAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPgIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLET 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1149773127 110 WLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALT 167
Cdd:cd15219    82 FLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLS 139
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-257 5.70e-06

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 47.10  E-value: 5.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLcYTATTVPQMLVNMGSSKKTIsYGGCTVQYAIF 108
Cdd:cd15132     1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDL-LILLCLPFDLYRLWKSRPWI-FGEFLCRLYHY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVL--AAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLPFCGRQVLNNFFCEVP 186
Cdd:cd15132    79 ISEGCTYATILhiTALSIERYLAICFPLRAKVLVTRRRVKCVIAALWA---------FALLSAGPFLFLVGVEQDNNIHP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 187 AMIKLSCADT--AVNDTTLAVLV----AFFVLVPLALIILsYGFITRAVLRIQSSKGRRKAFGTCSSH------LVVVSL 254
Cdd:cd15132   150 DDFSRECKHTpyAVSSGLLGIMIwvttTYFFLPMLCLSFL-YGFIGRKLWKSKNDLRGPNAAARERSHrqtvriLAVVVL 228

                  ...
gi 1149773127 255 FYL 257
Cdd:cd15132   229 AFI 231
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
31-258 5.96e-06

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 47.31  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYtATTVPQMLVNMGSSKKTIsYGG--CTVQYAIF 108
Cdd:cd15168     3 LPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLY-LLSLPFLIYYYANGDHWI-FGDfmCKLVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnsLVQVALTVQLPFCGRQVLNNffcevpam 188
Cdd:cd15168    81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWI------LVLLQLLPILFFATTGRKNN-------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 iKLSCADTAVNDT-------TLAVLVAFFvLVPLALIILSYGFITRAVLR----IQSSKGRRKAFGTCSSHLVVVSLFYL 257
Cdd:cd15168   147 -RTTCYDTTSPEElndyviySMVLTGLGF-LLPLLIILACYGLIVRALIRklgeGVTSALRRKSIRLVIIVLALFAVCFL 224

                  .
gi 1149773127 258 P 258
Cdd:cd15168   225 P 225
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
33-235 6.42e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 47.24  E-value: 6.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILV-SRldPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH-- 109
Cdd:cd14978     5 YVLPVICIFGIIGNILNLVVlTR--KSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYIyp 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 ---WLGCTECVVLAAMALDRYVAICEPLRYaavmhRALCQqlVAAAWLSGFGNSLVQVALTVQLPFcGRQVLNNFFCEVP 186
Cdd:cd14978    83 lanTFQTASVWLTVALTVERYIAVCHPLKA-----RTWCT--PRRARRVILIIIIFSLLLNLPRFF-EYEVVECENCNNN 154
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1149773127 187 AMIKLSCADTAVNDTTLAV-----LVAFFVLVPLALIILSYGFITRAVLRIQSS 235
Cdd:cd14978   155 SYYYVIPTLLRQNETYLLKyyfwlYAIFVVLLPFILLLILNILLIRALRKSKKR 208
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
33-157 7.83e-06

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 46.76  E-value: 7.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGN--IAIILVSRLDPQ-LQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFH 109
Cdd:cd15355     5 AIYLALFVVGTVGNsiTLYTLARKKSLQhLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGYYFL 84
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVVL--AAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGF 157
Cdd:cd15355    85 RDACTYATALnvASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASA 134
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
34-161 8.00e-06

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 46.69  E-value: 8.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMgSSKKTISYG--GCTVQYAIFHWL 111
Cdd:cd15212     6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTL-FSRPGWLFGdrLCLANGFFNACF 84
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1149773127 112 GCTECVVLAAMALDRYVAICEPLRYAAVMHRALcqQLVAAAWLSGFGNSL 161
Cdd:cd15212    85 GIVSTLTMTLISFDRYYAIVRQPQGKIGRRRAL--QLLAAAWLTALGFSL 132
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
33-302 1.09e-05

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 46.38  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLG 112
Cdd:cd15215     4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRqvlnNFFCEVPamikls 192
Cdd:cd15215    84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDER----NALCSVI------ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 193 cadTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVV---SLFYLPAIYMYLQPPSS 269
Cdd:cd15215   154 ---WGSSYSYTILSVVSSFVLPVIIMLACYSMVFRAARRCYHCKAAKVIFIIIFSYVLSMgpySFLSVLAVWVDTQVPQW 230
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1149773127 270 YSQeqgkfISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15215   231 VIS-----IILWLFFLQCCIHPYIYGYMHKSIK 258
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
29-248 1.32e-05

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 46.06  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVP-QMLVNMgssKKTISYGG--Ctvqy 105
Cdd:cd15203     1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPfTLIYTL---TKNWPFGSilC---- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 aifHWLGCTECVV-------LAAMALDRYVAICEPLRYAAVMHRALCqqLVAAAWLSGFGNSlvqvaltvqLPFCGRQVL 178
Cdd:cd15203    74 ---KLVPSLQGVSifvstltLTAIAIDRYQLIVYPTRPRMSKRHALL--IIALIWILSLLLS---------LPLAIFQEL 139
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1149773127 179 NNFFCEVPAMIKLSCADTAVNDT-----TLAVLVAFFVLvPLALIILSYGFITRaVLRIQSSKGRRKAFGTCSSH 248
Cdd:cd15203   140 SDVPIEILPYCGYFCTESWPSSSsrliyTISVLVLQFVI-PLLIISFCYFRISL-KLRKRVKKKRGKRTLSSRRR 212
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
26-299 1.38e-05

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 45.98  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVLlvfyILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVN-MGSSKKTISYGGCTVQ 104
Cdd:cd15306     2 WAALLILMVI----IPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTiLFEAMWPLPLVLCPIW 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 105 YAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWlsgfgnsLVQVALTVQLPFCGRQVLNNFFCE 184
Cdd:cd15306    78 LFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVW-------LISIGIAIPVPIKGIETDVDNPNN 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 185 VPAMIKlscADTAVNDTTLAVLVAFFvlVPLALIILSYgFITRAVLRIQSSKGRRKAFGTCSshlVVVSLFYLPAIYMYL 264
Cdd:cd15306   151 ITCVLT---KERFGDFILFGSLAAFF--TPLAIMIVTY-FLTIHALRKQTITNEQRASKVLG---IVFFLFLLMWCPFFI 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1149773127 265 QPPSSYSQEQ------GKFISLFYSI--ITPTLNPFIYTLRNK 299
Cdd:cd15306   222 TNITSVLCDScnqttlQMLMEIFVWIgyVSSGVNPLVYTLFNK 264
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
31-154 1.43e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 45.81  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVP-QMLVNMGSSKKTISYGGCTVQYAiFH 109
Cdd:cd15067     2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfSILHEMTGGYWLFGRDWCDVWHS-FD 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1149773127 110 WLGCTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWL 154
Cdd:cd15067    81 VLASTASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
31-302 1.59e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 45.78  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILA-MLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqyaifh 109
Cdd:cd15064     2 LISVLLSLIILAtILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDI------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLG-----CTECVV-LAAMALDRYVAICEPLRYAA--VMHRALCqqLVAAAWLSGFGNSLVqvaltvqlPFCGRQVLNNf 181
Cdd:cd15064    76 WISldvtcCTASILhLCVIALDRYWAITDAVEYAHkrTPKRAAV--MIALVWTLSICISLP--------PLFGWRTPDS- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 182 fcEVPAMIKLScadTAVNDTTLAVLVAFFVlvPLALIILSYGFITRAvlriqSSKGRR--KAFGTCSSHLVVVSL-FYLP 258
Cdd:cd15064   145 --EDPSECLIS---QDIGYTIFSTFGAFYI--PLLLMLILYWKIYRA-----AARERKaaKTLGIILGAFIVCWLpFFLV 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1149773127 259 AIYMYLQPPSSYSQEQGKFIsLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15064   213 ALIVPLCSHCWIPLALKSFF-LWLGYFNSLINPLIYTFFNKDFR 255
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
31-140 1.65e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 45.65  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYAIFHW 110
Cdd:cd15325     3 LGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNI-WAAVDV 81
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1149773127 111 LGCTECVV-LAAMALDRYVAICEPLRYAAVM 140
Cdd:cd15325    82 LCCTASIMsLCIISIDRYIGVSYPLRYPSIM 112
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
30-304 2.63e-05

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 45.11  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYAIFH 109
Cdd:cd15050     2 PLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLF-WLSMD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLPFCGrqvLNNFFCEVPAM 188
Cdd:cd15050    81 YVASTASIFsLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWL---------LSFLWVIPILG---WHHFARGGERV 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTT-LAVLVAFF-VLVPLALIILSYGFITRAVLRiqsskgRRKAFGTCSSHLVVVSLFYLP--AIYMYL 264
Cdd:cd15050   149 VLEDKCETDFHDVTwFKVLTAILnFYIPSLLMLWFYAKIFKAVNR------ERKAAKQLGFIMAAFILCWIPyfILFMVI 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1149773127 265 QPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGT 304
Cdd:cd15050   223 AFCKNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKT 262
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
33-304 3.06e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 44.98  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTisyggctvqyAIFHWLG 112
Cdd:cd14972     3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTP----------SPATWLL 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVVLAAMA---------LDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLvqvaltvqLPFCGRqvlNNFFC 183
Cdd:cd14972    73 RKGSLVLSLLAsaysllaiaVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGW---NCVLC 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 184 EVPamiklSCADTAVNDT-TLAVLVAFFVLVPLALIILSYGFI---------------TRAVLRiQSSKGRRKAFgTCSS 247
Cdd:cd14972   142 DQE-----SCSPLGPGLPkSYLVLILVFFFIALVIIVFLYVRIfwclwrhanaiaarqEAAVPA-QPSTSRKLAK-TVVI 214
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 248 HLVVVSLFYLP-AIYMYLQP--PSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVKGT 304
Cdd:cd14972   215 VLGVFLVCWLPlLILLVLDVlcPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRA 274
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
33-294 3.84e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 44.59  E-value: 3.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFY----ILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTaTTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd14970     1 IVIPAVYsvvcVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFL-LGLPFLATSYLLGYWPFGEVMCKIVLSVD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRyaAVMHRALCQ-QLV-AAAWLsgfgnslvqVALTVQLPFCGRQVLNNFFCEVP 186
Cdd:cd14970    80 AYNMFTSIFCLTVMSVDRYLAVVHPVK--SLRFRTPRKaKLVsLCVWA---------LSLVLGLPVIIFARTLQEEGGTI 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 187 AMIkLSCADTAVNDTTLAVLVAFFV--LVPLALIILSYGFITRavlRIQSSkgrRKAFGTCSSH------------LVVV 252
Cdd:cd14970   149 SCN-LQWPDPPDYWGRVFTIYTFVLgfAVPLLVITVCYSLIIR---RLRSS---RNLSTSGAREkrrarrkvtrlvLVVV 221
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1149773127 253 SLF---YLPaIYMY-------LQPPSSYsqeqgkFISLFYSIIT-----PTLNPFIY 294
Cdd:cd14970   222 AVFvvcWLP-FHVFqivrlliDPPETLT------VVGVFLFCIAlsyanSCLNPILY 271
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
34-155 4.17e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 44.49  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQ--MLVNMGSSKKTISYGGCTVQYAIFHWL 111
Cdd:cd15352     6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLEtiMIAVLNSGYLVISDQFIQHMDNVFDSM 85
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1149773127 112 GCTECVV----LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLS 155
Cdd:cd15352    86 ICISLVAsicnLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVV 133
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
33-153 4.18e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 44.43  E-value: 4.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLG 112
Cdd:cd15301     5 IVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLAS 84
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1149773127 113 CTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAW 153
Cdd:cd15301    85 NASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAW 125
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
33-155 4.97e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 44.02  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYAIFHWLG 112
Cdd:cd15062     5 VALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDV-WAAVDVLC 83
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1149773127 113 CTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLS 155
Cdd:cd15062    84 CTASIMsLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVL 127
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
29-142 5.38e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 44.11  E-value: 5.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPqmlvnMGSSKKTISYGG-----CTV 103
Cdd:cd15326     1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP-----FSATLEILGYWVfgrifCDI 75
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1149773127 104 qYAIFHWLGCTECVV-LAAMALDRYVAICEPLRYAAVMHR 142
Cdd:cd15326    76 -WAAVDVLCCTASILsLCAISIDRYIGVRHSLQYPTIVTR 114
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
27-302 5.98e-05

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 43.78  E-value: 5.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  27 LELPLFVVLLVFYILAMLgNIAIILVSRldpQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYA 106
Cdd:cd15334     3 ISLTLSILALMTTAINSL-VITAIIVTR---KLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 107 IFhwLGCTECVVL--AAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLP--FCGRQVLNNff 182
Cdd:cd15334    79 VD--ITCCTCSILhlSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWI---------ISIFISMPplFWRHQTTSR-- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 183 cEVPAMIKlscaDTAVNDTTLAVLVAFFvlVPLALIILSYGFITRAVLRiqsskgRRKA---FGTCSSHLVVVSL-FYLP 258
Cdd:cd15334   146 -EDECIIK----HDHIVFTIYSTFGAFY--IPLALILILYYKIYRAATR------ERKAattLGLILGAFVICWLpFFVK 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1149773127 259 AIYMYLQPPSSYSQEQGKFISlFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15334   213 EVIVNTCDSCYISEEMSNFLT-WLGYINSLINPLIYTIFNEDFK 255
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
37-301 6.33e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 44.16  E-value: 6.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  37 VFYILAMLGN-IAIILVSRLDPQLQ-SPMYIFLSHLSFLDLCYTATTVPQMLVNMgSSKKTISYGG--CTVQYAIFHWLG 112
Cdd:cd14981     9 LMFVFGVLGNlLALIVLARSSKSHKwSVFYRLVAGLAITDLLGILLTSPVVLAVY-ASNFEWDGGQplCDYFGFMMSFFG 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAW----------LSGFGNSLVQVALT-VQLPFCGRQVLNNF 181
Cdd:cd14981    88 LSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWafalliaslpLLGLGSYVLQYPGTwCFLDFYSKNTGDAA 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 182 FCEVPAMIKLSCadtavndttLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRRKAFGTC---SSHLVVVSLFYLP 258
Cdd:cd14981   168 YAYLYSILGLLI---------LLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKRNEIQMVvllLAITVVFSVCWLP 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1149773127 259 AIYMYLQPPSSYSQEQGKF--ISLFYSIITPTLNPFIYTLRNKDV 301
Cdd:cd14981   239 LMIRVLINATGDSEKNGKTdlLAVRMASWNQILDPWVYILLRKEV 283
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
33-222 9.32e-05

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 43.41  E-value: 9.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLG 112
Cdd:cd15210     5 VWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQValtvqLPFCGRQVLNnffcevPAMIKLS 192
Cdd:cd15210    85 AVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLW-----LGIWGRFGLD------PKVCSCS 153
                         170       180       190
                  ....*....|....*....|....*....|
gi 1149773127 193 CADTAVNDTTLAVLVAFFVLVPLALIILSY 222
Cdd:cd15210   154 ILRDKKGRSPKTFLFVFGFVLPCLVIIICY 183
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-302 1.08e-04

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 43.20  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTaTTVPQMLVNMGSSKKTISYGGC---------TV 103
Cdd:cd14999     4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYL-LTIPFYVSTYFLKKWYFGDVGCrllfsldflTM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 104 QYAIFhwlgctecvVLAAMALDRYVAICEPLRyAAVMHRALCQQLVAAAWLSGFGNSLvQVALTVQLPFCGRQVLNNFFC 183
Cdd:cd14999    83 HASIF---------TLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIWLLSLLLTL-PMAIMIRLVTVEDKSGGSKRI 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 184 EVPAMIKLScadtavNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKG--------RRKAFGTCSSHLVVVSLF 255
Cdd:cd14999   152 CLPTWSEES------YKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASnssrkrlpKQKVLKMIFTIVLVFWAC 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1149773127 256 YLP-------AIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd14999   226 FLPfwiwqllYLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
34-157 1.17e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 43.27  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTV-PQMLVNMgsskkTISYGG----CTV--QYA 106
Cdd:cd15385     6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVlPQLCWDI-----TYRFYGpdflCRIvkHLQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1149773127 107 IFHWLGCTecVVLAAMALDRYVAICEPLRyaaVMHRALCQQ--LVAAAWLSGF 157
Cdd:cd15385    81 VLGMFAST--YMLVMMTADRYIAICHPLK---TLQQPTKRSylMIGSAWALSF 128
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
31-304 1.43e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 42.64  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGN----IAIILVSRLdpqlQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYA 106
Cdd:cd15329     3 IGIVLLIIILGTVVGNalviIAVCLVKKL----RTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDV-WI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 107 IFHWLGCTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSgfgnslvqvALTVQLP---FCGRQVLNNFF 182
Cdd:cd15329    78 SFDVLLCTASILnLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLL---------SALISIPplfGWKNKVNDPGV 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 183 CEVpamiklsCADTAVndTTLAVLVAFFvlVPLALIILSYGFITRAvlriqsSKGRRKAFGTCSshlVVVSLF---YLP- 258
Cdd:cd15329   149 CQV-------SQDFGY--QIYATFGAFY--IPLIVMLVLYYKIYRA------AKSERKAIKTLG---IIMGAFtlcWLPf 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1149773127 259 AIYMYLQP---PSSYSQEQGKFISLF----YSiiTPTLNPFIYTLRNKDVKGT 304
Cdd:cd15329   209 FILALLRPflkPIKCSCIPLWLSRLFlwlgYA--NSFLNPIIYAKFNREFRTP 259
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
38-227 1.50e-04

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 42.89  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  38 FYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGCTECV 117
Cdd:cd15391    10 TIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 118 VLAAMALDRYVAICEPLRYAAVMHRALCqqLVAAAWLSGFGNSLVQValtvqlpFCGRQVLNNFFCEvpamIKLSCADTA 197
Cdd:cd15391    90 TNTAIGIDRFFAVIFPLRSRHTKSRTKC--IIASIWAISFSLSSVQL-------FAGRTQRYGQYSE----GRVLCGESW 156
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1149773127 198 VNDTTLAVLVAFFVL-----VPLALIILSYGFITR 227
Cdd:cd15391   157 PGPDTSRSAYTVFVMlltyiIPLLILTSTYGYVGF 191
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
26-302 1.59e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 42.87  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  26 WLELPLFVVLLvfyiLAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQY 105
Cdd:cd15054     2 WVAAFLCLIIL----LTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 AiFHWLGCTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCE 184
Cdd:cd15054    78 A-FDVMCCSASILnLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 185 VPAMIKLscaDTAVNDTTLAVLVAFFvlVPLALIILSYGFITRAvlriqsSKGRRKAFGTCSSHLVVVSLFYLPAIYMYL 264
Cdd:cd15054   157 VEGQCRL---LVSLPYALVASCLTFF--LPSGAICFTYCRILLA------ARKALKASLTLGILLGMFFVTWLPFFVANV 225
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1149773127 265 QPPSSYSQEQGKFISLFY-SIITPTLNPFIYTLRNKDVK 302
Cdd:cd15054   226 VQAVCDCVSPGLFDVLTWlGYCNSTMNPIIYPLFMRDFK 264
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
33-155 1.77e-04

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 42.59  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPqmlvnmgsSKKTISYGGCTVQYAIFH--W 110
Cdd:cd15327     5 VFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLP--------FSATLEVLGFWAFGRVFCdiW 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1149773127 111 -----LGCTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLS 155
Cdd:cd15327    77 aavdvLCCTASILsLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVS 127
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
33-298 1.99e-04

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 42.33  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVP---QMLVNMGssKKTISYGGCTVqYAIFH 109
Cdd:cd15053     5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPfavYVEVNGG--KWYLGPILCDI-YIAMD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 110 WLGCTECVV-LAAMALDRYVAICEPLRYA--AVMHRALCqqLVAAAWLsgfgnslvqVALTVQLP-FCGrqvLNNFFCEV 185
Cdd:cd15053    82 VMCSTASIFnLCAISIDRYIAVTQPIKYArqKNSKRVLL--TIAIVWV---------VSAAIACPlLFG---LNNVPYRD 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 186 PAMIKLSCADTAVndttLAVLVAFFvlVPLALIILSYGFITRAVLRiqsskgRRKAFGTCSSHLVVVSLFYLP------- 258
Cdd:cd15053   148 PEECRFYNPDFII----YSSISSFY--IPCIVMLLLYYRIFRALRR------EKKATKTLAIVLGVFLFCWLPfftlnil 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1149773127 259 -AIYMYLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15053   216 nAICPKLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFN 256
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
40-304 2.03e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 42.46  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  40 ILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNmgSSKKTISYGGCTVQYAIFHWLGCTECVVL 119
Cdd:cd15070    12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVV--SLGVTIHFYSCLFMSCLLVVFTHASIMSL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 120 AAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMIKLScadtavn 199
Cdd:cd15070    90 LAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRMD------- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 200 dttLAVLVAFF--VLVPLALIILSYGFITRAVLR---------IQSSKGRRKAFGTCSSHLVVVSLF---YLP------A 259
Cdd:cd15070   163 ---YMVYFSFFtwILIPLVIMCALYVDIFYIIRNklsqnatgfRETGAFYGREFKTAKSLALVLFLFavcWLPlsiincV 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1149773127 260 IYMYLQPPSSYSqeqgkFISLFYSIITPTLNPFIYTLRNKDVKGT 304
Cdd:cd15070   240 VYFNPKVPKIAL-----YLGILLSHANSMMNPIVYACKIKKFKET 279
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
33-304 2.07e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 42.25  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCtVQYAIFHWLG 112
Cdd:cd15307     5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHC-LTWICLDVLF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLvqvALTVQLPFCGRQVLNNFFCEVPAMIKl 191
Cdd:cd15307    84 CTASIMhLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL---PLSLMYSKDHASVLVNGTCQIPDPVY- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 192 scadtavndTTLAVLVAFFVlvPLALIILSYGFITRAVLRIQSSKGR-----RKAFGTCSSHLVVVSLFYLPAIYMYLQP 266
Cdd:cd15307   160 ---------KLVGSIVCFYI--PLGVMLLTYCLTVRLLARQRSRHGRiirleQKATKVLGVVFFTFVILWSPFFVLNLLP 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1149773127 267 PSSYSQE---QGKFISL--FYSIITPTLNPFIYTLRNKDVKGT 304
Cdd:cd15307   229 TVCAECEeriSHWVFDVvtWLGYASSMVNPIFYTIFNKVFRQA 271
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
34-153 2.38e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 42.23  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYA--IFHWL 111
Cdd:cd15354     6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnVFDSL 85
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1149773127 112 GCTECVV----LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAW 153
Cdd:cd15354    86 ICISVVAsmcsLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
31-154 2.80e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 41.96  E-value: 2.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDlCYTATTVpqMLVNMGSSKKTISYGG---CTVQYAI 107
Cdd:cd15312     3 MYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITD-FLLGFLV--MPYSMVRSVESCWYFGdlfCKIHSSL 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 108 FHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWL 154
Cdd:cd15312    80 DMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWS 126
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
35-153 3.02e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 42.20  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  35 LLVFYILAML-GNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGC 113
Cdd:cd15959     6 LLSLAILVIVgGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVT 85
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1149773127 114 TECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAW 153
Cdd:cd15959    86 ASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVW 125
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
30-294 3.58e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 41.87  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  30 PLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTaTTVPQMLV-NMGSSKKTISYGGCTVQYAIF 108
Cdd:cd14982     2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFV-LTLPFRIYyYLNGGWWPFGDFLCRLTGLLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSgfgnSLVQVALTVQLPFCGRQVLNNFFCevpaM 188
Cdd:cd14982    81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWIL----VLVASVPLLLLRSTIAKENNSTTC----F 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLvPLALIILSYGFITRAVLRI----QSSKGRRKAFGTCSSHLVVVSLFYLP-----A 259
Cdd:cd14982   153 EFLSEWLASAAPIVLIALVVGFLI-PLLIILVCYSLIIRALRRRskqsQKSVRKRKALRMILIVLAVFLVCFLPyhvtrI 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1149773127 260 IYMYLQPPSSYSQEQGKFISLFYSIITPT------LNPFIY 294
Cdd:cd14982   232 LYLLVRLSFIADCSARNSLYKAYRITLCLaslnscLDPLIY 272
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-165 3.83e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 41.71  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYA--IFHWL 111
Cdd:cd15103     6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnVIDSM 85
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1149773127 112 GCTECVV----LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVA 165
Cdd:cd15103    86 ICSSLLAsicsLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFII 143
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
37-231 4.10e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 41.39  E-value: 4.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  37 VFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDL-----CYTATTVPQMLVNM--GSS--KKTISYGGCTVQYAI 107
Cdd:cd15978     9 LIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLmlclfCMPFTLIPNLLKDFifGSAvcKTATYFMGISVSVST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 108 FHwlgctecvvLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGrqvLNNffcEVPA 187
Cdd:cd15978    89 FN---------LVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTR---INN---STGN 153
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1149773127 188 MIKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLR 231
Cdd:cd15978   154 MCRLLWPNDVTQQSWYIFLLLILFLIPGIVMMTAYGLISLELYR 197
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
33-236 4.74e-04

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 41.39  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGN---IAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQ-YAIF 108
Cdd:cd15356     5 AVYALIWALGAAGNaltIHLVLKKRSLRGLQGTVHYHLVSLALSDLLILLISVPIELYNFVWFHYPWVFGDLVCRgYYFV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLgCTECVVL--AAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTvqlpfcGRQVLNNFFCEVP 186
Cdd:cd15356    85 RDI-CSYATVLniASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFIM------GQKYELETADGEP 157
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1149773127 187 AMIKLSCAdTAVNDTTLAVLVAFFVLV----PLALIILsYGFITRAVLRIQSSK 236
Cdd:cd15356   158 EPSSRVCT-VLVSRATLKVFIQVNAFVsfvlPLALIAF-LNGVTVSHLRIQSLQ 209
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
32-296 6.13e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 40.91  E-value: 6.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  32 FVVLLVFY---ILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd14971     1 WIVPLFFAlifLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLPFCGRQVLNNFFCEVPAm 188
Cdd:cd14971    81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWV---------VSLAVAAPVLALHRLRNYTPGNRT- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 iklSCADTAVN-DTTLAVLVAFFV---LVPLALIILSYGFITR-----AVLRIQSSKGRRKAFGTCSSHLVVVSLF---Y 256
Cdd:cd14971   151 ---VCSEAWPSrAHRRAFALCTFLfgyLLPLLLICVCYAAMLRhlwrvAVRPVLSEGSRRAKRKVTRLVLVVVVLFaacW 227
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1149773127 257 LP--AIYMYL---QPPSSYSQEQGKFISLFYSIITPTLNPFIYTL 296
Cdd:cd14971   228 GPihAILLLValgPFPLTYATYALRIWAHCLAYSNSAVNPVLYAF 272
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
29-135 6.62e-04

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 40.90  E-value: 6.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATtvpqMLVNMGSSKKTISYGG--CTVQYA 106
Cdd:cd15923     1 LLQYAIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLIS----LPFKMHSYRRESAGLQklCNFVLS 76
                          90       100
                  ....*....|....*....|....*....
gi 1149773127 107 IFHWLGCTECVVLAAMALDRYVAICEPLR 135
Cdd:cd15923    77 LYYINMYVSIFTITAISVDRYVAIRYPLR 105
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
29-257 7.20e-04

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 40.76  E-value: 7.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIA---IILVSRLdpQLQSPMYIFLSHLSFLDLCYTATTVPqmlvnmgsskKTISYGGcTVQy 105
Cdd:cd15382     1 LVSIIVYSVLFLIAAVGNLTvllILLRNRR--RKRSRVNILLMHLAIADLLVTFIMMP----------LEIGWAA-TVA- 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 106 aifhWLG----CTECV------------VLAAMALDRYVAICEPLRYAAVMHRAlcQQLVAAAWLSGFGNSLVQVALtvq 169
Cdd:cd15382    67 ----WLAgdflCRLMLffrafglylssfVLVCISLDRYFAILKPLRLSDARRRG--RIMLAVAWVISFLCSIPQSFI--- 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 170 lpFCGRQ----------VLNNFFcevpamiklsCADTAVNDTTLAVLVAFFVLvPLALIILSYGFITRAVLRIQSSKGRR 239
Cdd:cd15382   138 --FHVEShpcvtwfsqcVTFNFF----------PSHDHELAYNIFNMITMYAL-PLIIIVFCYSLILCEISRKSKEKKED 204
                         250
                  ....*....|....*...
gi 1149773127 240 KAFGTCSSHLVVVSLFYL 257
Cdd:cd15382   205 VSEKSSSVRLRRSSVGLL 222
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
29-153 7.21e-04

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 40.66  E-value: 7.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAmlGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVP--QMLVNMGsskkTISYGG--CTVQ 104
Cdd:cd15958     3 MSLLMALIVLLIVA--GNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPfgATLVVRG----RWLYGSffCELW 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1149773127 105 YAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAW 153
Cdd:cd15958    77 TSVDVLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVW 125
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
33-239 7.27e-04

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 40.72  E-value: 7.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFY----ILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYtATTVPQMLVNMGSSK-------KTISYggc 101
Cdd:cd15178     1 LALCVIYvlvfLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLF-ALTLPFWAVSVVKGWifgtfmcKLVSL--- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 102 tVQYAIFHwlgcTECVVLAAMALDRYVAICEPLRyaAVMHRALCQQLVAAA-WLsgfgnslvqVALTVQLPFC-GRQVLN 179
Cdd:cd15178    77 -LQEANFY----SGILLLACISVDRYLAIVHATR--ALTQKRHLVKFVCAGvWL---------LSLLLSLPALlNRDAFK 140
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1149773127 180 NffcevPAMIKLSCADTAVNDTT---------LAVLVAFFvlVPLALIILSYGFITRAVLRIQSSKGRR 239
Cdd:cd15178   141 P-----PNSGRTVCYENLGNESAdkwrvvlriLRHTLGFL--LPLVVMLFCYGFTIKTLLQTRSFQKHR 202
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
45-304 1.14e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 40.00  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  45 GNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGCTECVVLAAMAL 124
Cdd:cd15049    17 GNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 125 DRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFgnsLVQVALTVQLP-FCGRQVLNNFFCEVPAMiklscADTAVndTTL 203
Cdd:cd15049    97 DRYFSVTRPLTYRAKRTPKRAILMIALAWVISF---VLWAPAILGWQyFVGERTVPDGQCYIQFL-----DDPAI--TFG 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 204 AVLVAFFvlVPLALIILSYGFITRAVLRiqsskgRRKAFGTCSSHLVVVSLFYLPAIYMYLQPPSSYSQEQGKFISLFYS 283
Cdd:cd15049   167 TAIAAFY--LPVLVMTILYWRIYRETAR------ERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLWSFGYW 238
                         250       260
                  ....*....|....*....|...
gi 1149773127 284 I--ITPTLNPFIYTLRNKDVKGT 304
Cdd:cd15049   239 LcyINSTINPFCYALCNKTFRKT 261
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
33-300 1.15e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 40.11  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTisYGGCTVQ-YAIFHWL 111
Cdd:cd15060     5 ILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWL--FGIHLCQmWLTCDIL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 112 GCTECVV-LAAMALDRYVAICEPLRYAA--VMHRALCqqLVAAAWLSgfgNSLVQVAltvqlPFCGrqvLNNFfcEVPAM 188
Cdd:cd15060    83 CCTASILnLCAIALDRYWAIHDPINYAQkrTLKRVLL--MIVVVWAL---SALISVP-----PLIG---WNDW--PENFT 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 189 IKLSCADTAVNDTTL-AVLVAFFvlVPLALIILSYGFITRAvlriqSSKGRRKAfGTCSSHLVVVSLFYLPAIYMYLQPP 267
Cdd:cd15060   148 ETTPCTLTEEKGYVIySSSGSFF--IPLLIMTIVYVKIFIA-----TSKERRAA-RTLGIIMGVFVVCWLPFFLMYVILP 219
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1149773127 268 ----SSYSQEQGKFISlFYSIITPTLNPFIYTLRNKD 300
Cdd:cd15060   220 fcetCSPSAKVVNFIT-WLGYVNSALNPVIYTIFNLD 255
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
31-233 1.16e-03

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 40.28  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15401     3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqvaLTVQlpfcgrQVLNNFFCEV----P 186
Cdd:cd15401    83 SVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWV-----------LTLA------AIVPNFFVGSlqydP 145
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 187 AMIKLSCADTAVNDTTLAVLVAFFVlVPLALIILSYGFITRAVLRIQ 233
Cdd:cd15401   146 RIYSCTFAQTVSSSYTITVVVVHFI-VPLSIVTFCYLRIWVLVIQVK 191
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
31-258 1.25e-03

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 39.89  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15377     3 LPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnsLVQVALTVQLPFCGRQVLNNffcevpamIK 190
Cdd:cd15377    83 NLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWL------IVVVAISPILFYSGTGVRKN--------KT 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLA------VLVAFFVLVPLALIILSYGFITRAVL-------RIQSSKGRRKAFGTCSSHLVVVSLFYL 257
Cdd:cd15377   149 ITCYDTTSDEYLRSyfiysmCTTVAMFCVPFILILGCYGLIVRALIykdmkytEENNAPLRRKSIYLVIIVLTVFAVSYL 228

                  .
gi 1149773127 258 P 258
Cdd:cd15377   229 P 229
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
33-300 1.33e-03

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 39.74  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLG 112
Cdd:cd15162     5 AVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFgnsLVQVALTVQlpfcgRQVLnnffcEVPAMIKLS 192
Cdd:cd15162    85 YCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLAL---LVTLPLYLV-----KQTI-----FLPALDITT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 193 CADTAVNDTTLAVLVAFFV-------LVPLALIILSYGFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLF--------YL 257
Cdd:cd15162   152 CHDVLPEQLLVGDWFYYFLslaivgfLIPFILTASCYVATIRTLAALEDENSEKKKKRAIKLAATVLAIFiicfapsnLL 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1149773127 258 PAIYMYLQPPSSYSQEQGKF-ISLFYSIITPTLNPFIYTLRNKD 300
Cdd:cd15162   232 LLAHYSLISSSGTGHLYFAYlLALCLSTLNSCIDPFIYYFVSKE 275
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
62-294 1.76e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 39.35  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  62 PMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMH 141
Cdd:cd15372    33 PSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 142 RALCQQLVAAAWLsgfGNSLVQVALTVQLPFCGRQVLNNFFCE--VPAMIKLSCADTAvndttLAVLVAFFVLVPLALII 219
Cdd:cd15372   113 RRFALCMCTAIWL---IAAALTLPLTLQRQSYPLERLNITLCHdvLPLDEQDTYLFYY-----FACLAVLGFLLPLVVIL 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 220 LSYGFITRAVLRiqssKGRRKAFGTCSSHLVVVS--LFYLPAIYMYLQPPSSYSQEQGK------FISLFYSIITPTLNP 291
Cdd:cd15372   185 FCYGSVLHTLLR----SGQRYGHAMKLTVLVLVSfvLCFTPSNLLLLLHYSDPTLDDGGnlyivyMVSLAISTLNSCVDP 260

                  ...
gi 1149773127 292 FIY 294
Cdd:cd15372   261 FIY 263
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
31-227 1.92e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 39.68  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTvqyaIFHW 110
Cdd:cd15208     3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCK----IIPY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVV----LAAMALDRYVAICEPLRYAAVMHRAlcQQLVAAAWLSGFGNSLVQ-VALTVQLPFCGRQVLNNFfcev 185
Cdd:cd15208    79 LQTVSVSVsvltLSCIALDRWYAICHPLMFKSTAKRA--RVSILIIWIVSLLIMIPQaIVMECSRVVPLANKTILL---- 152
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1149773127 186 pamikLSCADTAVNDTTLAVLVAFFVLV----PLALIILSYGFITR 227
Cdd:cd15208   153 -----TVCDERWSDSIYQKVYHICFFLVtyllPLCLMILAYFQIFR 193
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
33-303 1.93e-03

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 39.26  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYAIFHWLG 112
Cdd:cd15331     5 IILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDM-WISMDVLC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVV-LAAMALDRYVAICEplryAAVMHRALCQQ---LVAAAWLsgfgnslvqVALTVQL-PFCGRQvlNNFFCEVPA 187
Cdd:cd15331    84 CTASILhLVAIALDRYWAVTN----IDYIRRRTAKRiliMIAVVWF---------VSLIISIaPLFGWK--DEDDLDRVL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 188 MIKLSCADTAVNDTTLAVLVAFFVlvPLALIILSYGFITRAvlriqsSKGRRKAFGTCS---SHLVVVSL-FYLPAIYMY 263
Cdd:cd15331   149 KTGVCLISQDYGYTIFSTVGAFYV--PLLLMIIIYWKIYQA------AKRERKAARTLAiitGAFVVCWLpFFLVALVMP 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1149773127 264 LQPPSSYSQEQGKFIsLFYSIITPTLNPFIYTLRNKDVKG 303
Cdd:cd15331   221 FCGAWQISRFLESFF-LWLGYFNSLLNPIIYTIFSPDFRG 259
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
29-154 1.99e-03

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 39.37  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKK-TISYGGCTVQYAI 107
Cdd:cd15358     1 TPVCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPfLLGAGGCYFKTLL 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 108 FHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWL 154
Cdd:cd15358    81 FETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWV 127
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
33-300 2.36e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 38.97  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTaTTVPqMLVNMGSSKKTISYGG--CTVQYAIFHW 110
Cdd:cd15088     5 SVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFM-LGMP-FLIHQFAIDGQWYFGEvmCKIITALDAN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVQLPFCGRQVlnnfFCevpaMIK 190
Cdd:cd15088    83 NQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTT----FC----YVS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVNDTTLAVLVAFFvlVPLALIILSY----GFITRAVLRIQSSKGRRKAFGTCSSHLVVVSLFYLPAIYMY--- 263
Cdd:cd15088   155 LPSPDDLYWFTIYHFILGFA--VPLVVITVCYililHRLARGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHvvq 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1149773127 264 ---LQPPS-SYSQEQGKFISLFYSIITPTLNPFIYTLRNKD 300
Cdd:cd15088   233 lvnLAMNRpTLAFEVAYFLSICLGYANSCLNPFVYILVSEN 273
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
33-303 2.95e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 38.97  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSpmYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLG 112
Cdd:cd15220     4 FCMVLLDLTALVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGEAECRVYIFLSVC 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVVL--AAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALTVqlPFCGRQVLNNFFCEVPAMIK 190
Cdd:cd15220    82 LVSASILtiSAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWP--SYGGPAPIAARHCSLHWSHS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 191 LSCADTAVndttLAVLVAFfvLVPLALIILSYGFITRAVlriqsskGRRKAFGTCsshLVVVSLF---YLPAIYMYLQP- 266
Cdd:cd15220   160 GHRGVFVV----LFALVCF--LLPLLLILVVYCGVFKVF-------GGGKAALTL---AAIVGQFlccWLPYFAFHLYSa 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1149773127 267 ----PSSYSQEQGKFISLFYSiiTPTLNPFIYTLRNKDVKG 303
Cdd:cd15220   224 laasPVSGGEAEEVVTWLAYS--CFAVNPFFYGLLNRQIRE 262
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
34-166 3.16e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 38.87  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVN--MGSSKKTISYggCTVQYAiFHWL 111
Cdd:cd15065     5 FLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNdlLGYWLFGETF--CNIWIS-FDVM 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1149773127 112 GCTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVAL 166
Cdd:cd15065    82 CSTASILnLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHL 137
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
40-298 3.54e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 38.56  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  40 ILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLGCTECVVL 119
Cdd:cd15000    11 LFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVLAL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 120 AAMALDRYVAICEPLRyaAVMHRALCQQLVAAAWLSGFgnsLVQVALTVQLPFCGRQVLNnfFCEvpamiKLSCADTAVN 199
Cdd:cd15000    91 CAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWIVGL---LLALPLAIYRSYRERQWKN--FLE-----TYCAENTQVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 200 DTTLAVLVAFFVLVPLALIILSYGFI-------TRAVLRIQ---SSKGRRKAFGTCSSHLVVVSLFYLP----AIYMYLQ 265
Cdd:cd15000   159 PIYWHVIITVLVWLPLGIMLICYSAIfwkldkyERRVLRREhpsVVRYKKKAAKTLFIVLITFVVCRIPftalIFYRYKL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1149773127 266 PPSSYSQEQGK-------FISLFYSIITPTLNPFIYTLRN 298
Cdd:cd15000   239 VPNDNTQNSVSgsfhilwFASKYLMFLNAAVNPLIYGFTN 278
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
31-154 4.01e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 38.58  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGN-IAIILVSRLDpQLQSPMYIFLSHLSFLDLCYTATTVPqmlVNMGSSKKTISYGG---CTVQYA 106
Cdd:cd15317     3 IYIVLVLAMLITVSGNlVVIISISHFK-QLHSPTNMLVLSLATADFLLGLCVMP---FSMIRTVETCWYFGdlfCKFHTG 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1149773127 107 IFHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWL 154
Cdd:cd15317    79 LDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
25-302 4.72e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 38.24  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  25 PWLELPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLcytattvpqmLVNMgsSKKTISYggcTVQ 104
Cdd:cd15082    10 PWNFTVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADF----------LVSL--TGGTISF---LTN 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 105 YAIFHWLGCTECVV---------------LAAMALDRYVAICEPLRYAAVMHRALCQQLvAAAWLSGFGNSLVQVAltvq 169
Cdd:cd15082    75 ARGYFFLGVWACVLegfavtffgivalwsLAVLAFERFFVICRPLGNIRLQGKHAALGL-LFVWTFSFIWTIPPVL---- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 170 lpfcgrqvlnNFFCEVPAMIKLSCA----DTAVNDTTLavLVAFFV---LVPLALIILSYGFITRAVLRIQSSKGR---- 238
Cdd:cd15082   150 ----------GWSSYTVSKIGTTCEpnwySGNMHDHTY--IITFFTtcfILPLGVIFVSYGKLLQKLRKVSNTQGRlgna 217
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1149773127 239 RKAFGTCSSHLVVVSLFYLPAIYMY-------LQPPSSYSQEQGKFISLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15082   218 RKPERQVTRMVVVMIVAFMVCWTPYaafsilvTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFR 288
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
35-302 4.79e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 37.99  E-value: 4.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  35 LLVFYILamlGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYAIFHWLGCT 114
Cdd:cd15323    10 LIVFTIV---GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNI-YLALDVLFCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 115 ECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLPfcgrqVLNNFFCEVPAMIKLSC 193
Cdd:cd15323    86 SSIVhLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWL---------ISAVISFP-----PLISMYRDPEGDVYPQC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 194 adtAVNDTTLAVLV----AFFvlVPLALIILSYGFITRAvlriqsSKGRRKAFGTCSSHLVVV------SLFYLPAIYMY 263
Cdd:cd15323   152 ---KLNDETWYILSscigSFF--APCLIMILVYIRIYRV------AKAREKRFTFVLAVVMGVfvvcwfPFFFSYSLYGI 220
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1149773127 264 LQPPSSYSQEQGKFIsLFYSIITPTLNPFIYTLRNKDVK 302
Cdd:cd15323   221 CREACEVPEPLFKFF-FWIGYCNSSLNPVIYTIFNQDFR 258
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
31-298 5.01e-03

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 38.18  E-value: 5.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd14964     1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAW-LSGFGNSLVQVALTVQLPFCGRQVLNNFFCEVPAMI 189
Cdd:cd14964    81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWgVSLLLSIPPLVGKGAIPRYNTLTGSCYLICTTIYLT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 190 KLSCadtavndTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKGRR--KAFGTCSSHLVVVSLFYLPAIYMYLQPP 267
Cdd:cd14964   161 WGFL-------LVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKnlKATKSLLILVITFLLCWLPFSIVFILHA 233
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1149773127 268 SSYSQEQGK---FISLFYSIITPTLNPFIYTLRN 298
Cdd:cd14964   234 LVAAGQGLNllsILANLLAVLASTLNPFIYCLGN 267
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
121-296 5.31e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 38.08  E-value: 5.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 121 AMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSLVQVALT-----VQLPFCGRQVLNNFFCevpAMIKLSCAD 195
Cdd:cd15134    94 AFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTrivylEYPPTSGEALEESAFC---AMLNEIPPI 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 196 TAVndttLAVLVAFFVLVPLALIILSYGFITravLRIQSS----KGRRKAFGTCSSHL-----------VVVSLFY---- 256
Cdd:cd15134   171 TPV----FQLSTFLFFIIPMIAIIVLYVLIG---LQLRRStllrRGQRSVSGGRRSSQsrrtvlrmlvaVVVAFFIcwap 243
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1149773127 257 -----LPAIYM-YLQPPSSYSQEQGKFISLFYSIITPTLNPFIYTL 296
Cdd:cd15134   244 fhaqrLLTVYAkNMTPPYLFINRILFYISGVLYYVSSTVNPILYNV 289
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
31-233 5.62e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 37.84  E-value: 5.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  31 LFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHW 110
Cdd:cd15209     3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 111 LGCTECVVLAAMALDRYVAICEPLRYAAVMHRAlcqqlvaaawlsgfgNSLVQVALTVQLPFCGrqVLNNFFCEV----P 186
Cdd:cd15209    83 SVIGSIFNITAIAINRYCYICHSLQYDRLYSLR---------------NTCCYLCLTWLLTVLA--VLPNFFIGSlqydP 145
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 187 AMIKLSCADTAVNDTTLAVLVAFFvLVPLALIILSYGFITRAVLRIQ 233
Cdd:cd15209   146 RIYSCTFAQTVSTVYTITVVVIHF-LLPLLIVSFCYLRIWVLVLQVR 191
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
33-171 6.57e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 37.71  E-value: 6.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVN--MGSSkktisYGG---CTVqYAI 107
Cdd:cd15059     5 SIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNelMGYW-----YFGsvwCEI-WLA 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1149773127 108 FHWLGCTECVV-LAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLsgfgnslvqVALTVQLP 171
Cdd:cd15059    79 LDVLFCTASIVnLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWI---------ISAVISLP 134
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
29-136 7.49e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 37.62  E-value: 7.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  29 LPLFVVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVqYAIF 108
Cdd:cd15322     1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEI-YLAL 79
                          90       100
                  ....*....|....*....|....*....
gi 1149773127 109 HWLGCTECVV-LAAMALDRYVAICEPLRY 136
Cdd:cd15322    80 DVLFCTSSIVhLCAISLDRYWSITQAIEY 108
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
33-232 7.93e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 37.51  E-value: 7.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGNIAIILVSRLDPQLQSPMYIFLSHLSFLDLCYTATTVPQMLVNMGSSKKTISYGGCTVQYAIFHWLG 112
Cdd:cd15008     4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 113 CTECVVLAAMALDRYVAICEPLRYAAVMHRAlcQQLVAAAWL--SGFGNSLVQVALTVQLPFCgrqvlnNFFcevpamik 190
Cdd:cd15008    84 GVQIYVLLSICVDRFYTIVYPLSFKVSREKA--KKMIAASWLfdAAFVSPALFFYGSNWGPHC------NFF-------- 147
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1149773127 191 LSCADTAVNDTTLAVLVAFfvLVPLALIILSYGFITRAVLRI 232
Cdd:cd15008   148 LPDSWDGAAYAIIHLLVGF--LVPSILIILFYQKVIKYIWRI 187
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
34-258 8.87e-03

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 37.44  E-value: 8.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  34 VLLVFYILAM-----LGNIAIILVSRLdPQLQSPMYIFLSHLSFLDLCYTaTTVPQMLVNMGSSKKTISYGGCTVQYAIF 108
Cdd:cd15154     2 LHLVGYSLLFpvgllLNAVALWVFVRY-LRLHSVVSIYMCNLALSDLLFT-LSLPLRIYYYANHYWPFGNFLCQFSGSIF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127 109 HWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWLSGFGNSlVQVALTVQLPFCGRQVLNNFFCevpaM 188
Cdd:cd15154    80 QMNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGS-VPAAIVHSSSDCLLHGEKVYRC----F 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1149773127 189 IKLSCADTAVNDTTLAVLVAFFVLVPLALIILSYGFITRAVLRIQSSKG--RRKAFGTCSSHLVVVSLFYLP 258
Cdd:cd15154   155 ESFSDNDWKGLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQgrRRKTVRLLLVNLVIFLICFVP 226
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
33-154 9.26e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 37.35  E-value: 9.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149773127  33 VVLLVFYILAMLGN-IAIILVSRLDPQLQSPMYIFLSHLSFLD----LCYTATTVPQMLVNMGSSKKTIsyggCTVQYAI 107
Cdd:cd15104     4 VILAVLSPLIITGNlLVIVALLKLIRKKDTKSNCFLLNLAIADflvgLAIPGLATDELLSDGENTQKVL----CLLRMCF 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1149773127 108 FHWLGCTECVVLAAMALDRYVAICEPLRYAAVMHRALCQQLVAAAWL 154
Cdd:cd15104    80 VITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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