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Conserved domains on  [gi|1149726757|ref|XP_020189261|]
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uncharacterized methyltransferase At2g41040, chloroplastic [Aegilops tauschii subsp. strangulata]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 167-282 1.10e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 105.46  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 167 DYFKPVAGGILVDVSCGSGLFSRKFASSGAYsaVIALDFSENMLRQCydyiRQEETPMNTNLALVRADISRLPFASCSID 246
Cdd:COG2226    16 AALGLRPGARVLDLGCGTGRLALALAERGAR--VTGVDISPEMLELA----RERAAEAGLNVEFVVGDAEDLPFPDGSFD 89

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1149726757 247 AIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVATTF 282
Cdd:COG2226    90 LVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDF 125
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 167-282 1.10e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 105.46  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 167 DYFKPVAGGILVDVSCGSGLFSRKFASSGAYsaVIALDFSENMLRQCydyiRQEETPMNTNLALVRADISRLPFASCSID 246
Cdd:COG2226    16 AALGLRPGARVLDLGCGTGRLALALAERGAR--VTGVDISPEMLELA----RERAAEAGLNVEFVVGDAEDLPFPDGSFD 89

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1149726757 247 AIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVATTF 282
Cdd:COG2226    90 LVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDF 125
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 178-278 1.05e-22

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 90.80  E-value: 1.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 178 VDVSCGSGLFSRKFASSGAYsaVIALDFSENMLRQCYDYIRQEetpmntNLALVRADISRLPFASCSIDAIHAGAAIHCW 257
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR--VTGVDISPEMLELAREKAPRE------GLTFVVGDAEDLPFPDNSFDLVLSSEVLHHV 72

                          90       100
                  ....*....|....*....|.
gi 1149726757 258 PSPSNAIAEISRVLKPGGVFV 278
Cdd:pfam08241  73 EDPERALREIARVLKPGGILI 93
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 163-323 1.07e-19

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 86.57  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 163 QMAQDYFKPVAGGILvDVSCGSGLFSRKFASSGAYSAVIALDFSENMLRQCydyirqeETPMNTNLALVRADISRLPFAS 242
Cdd:TIGR02072  25 ALLKEKGIFIPASVL-DIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQA-------KTKLSENVQFICGDAEKLPLED 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 243 CSIDAIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVATTFLStptnsgpfsiDALRPLRQIVG-PVNssyNFFTEGELKD 321
Cdd:TIGR02072  97 SSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGP----------GTLHELRQSFGqHGL---RYLSLDELKA 163


                  ..
gi 1149726757 322 LC 323
Cdd:TIGR02072 164 LL 165
PRK08317 PRK08317
hypothetical protein; Provisional
 158-279 1.56e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 80.75  E-value: 1.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 158 RDEEFQMAQdyFKPvaGGILVDVSCGSGLFSRKFA-SSGAYSAVIALDFSENMLrqcyDYIRQEETPMNTNLALVRADIS 236
Cdd:PRK08317    8 RARTFELLA--VQP--GDRVLDVGCGPGNDARELArRVGPEGRVVGIDRSEAML----ALAKERAAGLGPNVEFVRGDAD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1149726757 237 RLPFASCSIDAIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVA 279
Cdd:PRK08317   80 GLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVV 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 177-283 9.47e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.99  E-value: 9.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 177 LVDVSCGSGLFSRKFASSGAYSaVIALDFSENMLRQCYDYIRQEETPmntNLALVRADISRLPFASC-SIDAIHAGAAIH 255
Cdd:cd02440     2 VLDLGCGTGALALALASGPGAR-VTGVDISPVALELARKAAAALLAD---NVEVLKGDAEELPPEADeSFDVIISDPPLH 77

                          90       100
                  ....*....|....*....|....*....
gi 1149726757 256 CWP-SPSNAIAEISRVLKPGGVFVATTFL 283
Cdd:cd02440    78 HLVeDLARFLEEARRLLKPGGVLVLTLVL 106
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 167-282 1.10e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 105.46  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 167 DYFKPVAGGILVDVSCGSGLFSRKFASSGAYsaVIALDFSENMLRQCydyiRQEETPMNTNLALVRADISRLPFASCSID 246
Cdd:COG2226    16 AALGLRPGARVLDLGCGTGRLALALAERGAR--VTGVDISPEMLELA----RERAAEAGLNVEFVVGDAEDLPFPDGSFD 89

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1149726757 247 AIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVATTF 282
Cdd:COG2226    90 LVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDF 125
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 178-278 1.05e-22

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 90.80  E-value: 1.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 178 VDVSCGSGLFSRKFASSGAYsaVIALDFSENMLRQCYDYIRQEetpmntNLALVRADISRLPFASCSIDAIHAGAAIHCW 257
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR--VTGVDISPEMLELAREKAPRE------GLTFVVGDAEDLPFPDNSFDLVLSSEVLHHV 72

                          90       100
                  ....*....|....*....|.
gi 1149726757 258 PSPSNAIAEISRVLKPGGVFV 278
Cdd:pfam08241  73 EDPERALREIARVLKPGGILI 93
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 176-275 8.42e-22

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 88.39  E-value: 8.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 176 ILvDVSCGSGLFSRKFASSGAYSaVIALDFSENMLRQCydyiRQEETPMNTNLALVRADISRLPFASCSIDAIHAGAAIH 255
Cdd:pfam13649   1 VL-DLGCGTGRLTLALARRGGAR-VTGVDLSPEMLERA----RERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLH 74

                          90       100
                  ....*....|....*....|..
gi 1149726757 256 CWPSP--SNAIAEISRVLKPGG 275
Cdd:pfam13649  75 HLPDPdlEAALREIARVLKPGG 96
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 163-323 1.07e-19

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 86.57  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 163 QMAQDYFKPVAGGILvDVSCGSGLFSRKFASSGAYSAVIALDFSENMLRQCydyirqeETPMNTNLALVRADISRLPFAS 242
Cdd:TIGR02072  25 ALLKEKGIFIPASVL-DIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQA-------KTKLSENVQFICGDAEKLPLED 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 243 CSIDAIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVATTFLStptnsgpfsiDALRPLRQIVG-PVNssyNFFTEGELKD 321
Cdd:TIGR02072  97 SSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGP----------GTLHELRQSFGqHGL---RYLSLDELKA 163


                  ..
gi 1149726757 322 LC 323
Cdd:TIGR02072 164 LL 165
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 173-286 9.93e-18

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 78.14  E-value: 9.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 173 AGGILVDVSCGSGLFSRKFASSGAysAVIALDFSENMLRQCYDYIRQeetpmnTNLALVRADISRLPFASCSIDAIHAGA 252
Cdd:COG2227    24 AGGRVLDVGCGTGRLALALARRGA--DVTGVDISPEALEIARERAAE------LNVDFVQGDLEDLPLEDGSFDLVICSE 95

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1149726757 253 AIHCWPSPSNAIAEISRVLKPGGVFvattFLSTP 286
Cdd:COG2227    96 VLEHLPDPAALLRELARLLKPGGLL----LLSTP 125
PRK08317 PRK08317
hypothetical protein; Provisional
 158-279 1.56e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 80.75  E-value: 1.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 158 RDEEFQMAQdyFKPvaGGILVDVSCGSGLFSRKFA-SSGAYSAVIALDFSENMLrqcyDYIRQEETPMNTNLALVRADIS 236
Cdd:PRK08317    8 RARTFELLA--VQP--GDRVLDVGCGPGNDARELArRVGPEGRVVGIDRSEAML----ALAKERAAGLGPNVEFVRGDAD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1149726757 237 RLPFASCSIDAIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVA 279
Cdd:PRK08317   80 GLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVV 122
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 144-290 6.83e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 75.96  E-value: 6.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 144 RGWRQNFnrsgfpgrdeefqMAQDYFKPvaGGILVDVSCGSGLFSRKFA-SSGAYSAVIALDFSENML---RQcydyiRQ 219
Cdd:PRK00216   37 RVWRRKT-------------IKWLGVRP--GDKVLDLACGTGDLAIALAkAVGKTGEVVGLDFSEGMLavgRE-----KL 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1149726757 220 EETPMNTNLALVRADISRLPFASCSIDAIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVATTFlSTPTNSG 290
Cdd:PRK00216   97 RDLGLSGNVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILEF-SKPTNPP 166
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
173-281 7.78e-16

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 72.16  E-value: 7.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 173 AGGILVDVSCGSGLFSRKFASSGAYSAVIALDFSENMLRQCydyirQEETPmntNLALVRADISRLPFAScSIDAIHAGA 252
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARA-----RARLP---NVRFVVADLRDLDPPE-PFDLVVSNA 71

                          90       100
                  ....*....|....*....|....*....
gi 1149726757 253 AIHCWPSPSNAIAEISRVLKPGGVFVATT 281
Cdd:COG4106    72 ALHWLPDHAALLARLAAALAPGGVLAVQV 100
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 137-290 3.87e-14

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 70.75  E-value: 3.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 137 LVSFLYERGWRQNFNRSGFPGRDEEfqmaqdyfkpvaggiLVDVSCGSGLFSRKFASSGAYSA-VIALDFSENMLRqcyd 215
Cdd:TIGR01934  18 LLSFGLHRLWRRRAVKLIGVFKGQK---------------VLDVACGTGDLAIELAKSAPDRGkVTGVDFSSEMLE---- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1149726757 216 yIRQEETPMNTNLALVRADISRLPFASCSIDAIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVATTFlSTPTNSG 290
Cdd:TIGR01934  79 -VAKKKSELPLNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEF-SKPANAL 151
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 178-277 5.86e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 64.31  E-value: 5.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 178 VDVSCGSGLFSRKFASSGAYSAVIALDFSENMLRQCYDYIRQEETPMNTNLALVRADISRLPFAScsIDAIHAGAAIHCW 257
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGS--FDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|
gi 1149726757 258 PSPSNAIAEISRVLKPGGVF 277
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGVL 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 177-283 9.47e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.99  E-value: 9.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 177 LVDVSCGSGLFSRKFASSGAYSaVIALDFSENMLRQCYDYIRQEETPmntNLALVRADISRLPFASC-SIDAIHAGAAIH 255
Cdd:cd02440     2 VLDLGCGTGALALALASGPGAR-VTGVDISPVALELARKAAAALLAD---NVEVLKGDAEELPPEADeSFDVIISDPPLH 77

                          90       100
                  ....*....|....*....|....*....
gi 1149726757 256 CWP-SPSNAIAEISRVLKPGGVFVATTFL 283
Cdd:cd02440    78 HLVeDLARFLEEARRLLKPGGVLVLTLVL 106
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
151-298 1.92e-12

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 65.02  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 151 NRSGFPGRDEEFQMAQDYFKPVAGGILVDVSCGSGLFSRKFASsgAYSAVIALDFSENMLRQCYD---YIRqeetpmntn 227
Cdd:COG4976    24 EDLGYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRP--RGYRLTGVDLSEEMLAKAREkgvYDR--------- 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1149726757 228 laLVRADISRLPFASCSIDAIHAGAAIHCWPSPSNAIAEISRVLKPGGVFVATTFLSTPTNSGPFSIDALR 298
Cdd:COG4976    93 --LLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSVEDADGSGRYAHSLDYVR 161
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 173-282 3.66e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 57.81  E-value: 3.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 173 AGGILVDVSCGSGLFSRKFAS-SGAYSAVIALDFSENMLRQCydyiRQEETPMN-TNLALVRADISRLP--FASCSIDAI 248
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKA----RENAQKLGfDNVEFEQGDIEELPelLEDDKFDVV 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1149726757 249 HAGAAIHCWPSPSNAIAEISRVLKPGGVFVATTF 282
Cdd:pfam13847  79 ISNCVLNHIPDPDKVLQEILRVLKPGGRLIISDP 112
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
171-290 6.71e-10

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 58.60  E-value: 6.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 171 PVAGGILVDVSCGSGLFSRKFA-SSGAYSAVIALDFSENMLRQCYDYIRQEETpmnTNLALVRADISRLPFASCSIDAIH 249
Cdd:pfam01209  40 VKRGNKFLDVAGGTGDWTFGLSdSAGSSGKVVGLDINENMLKEGEKKAKEEGK---YNIEFLQGNAEELPFEDDSFDIVT 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1149726757 250 AGAAIHCWPSPSNAIAEISRVLKPGGVFVATTFlSTPTNSG 290
Cdd:pfam01209 117 ISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEF-SKPENPL 156
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 146-323 7.60e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 58.00  E-value: 7.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 146 WRQNFNRSGFPGRDEEFQMAQDYFKpvaGGILVDVSCGSGLFSRKFASSGAySAVIALDFSENMLRQCydyiRQEETPMN 225
Cdd:COG0500     2 WDSYYSDELLPGLAALLALLERLPK---GGRVLDLGCGTGRNLLALAARFG-GRVIGIDLSPEAIALA----RARAAKAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 226 -TNLALVRADISRL-PFASCSIDAIHAGAAIHcWPSPSN---AIAEISRVLKPGGVFVAT-----------TFLSTPTNS 289
Cdd:COG0500    74 lGNVEFLVADLAELdPLPAESFDLVVAFGVLH-HLPPEEreaLLRELARALKPGGVLLLSasdaaaalslaRLLLLATAS 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1149726757 290 GPFSIDALRPLRQIVGPVNSSYNFFTEGELKDLC 323
Cdd:COG0500   153 LLELLLLLRLLALELYLRALLAAAATEDLRSDAL 186
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 174-274 7.80e-09

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 55.67  E-value: 7.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 174 GGILVDVSCGSG----LFSRKFASSGAysaVIALDFSENMLRQCYDYIRQEETPMNTNLALVRADISRLPFASCSIDAIH 249
Cdd:PLN02233   74 GDRVLDLCCGSGdlafLLSEKVGSDGK---VMGLDFSSEQLAVAASRQELKAKSCYKNIEWIEGDATDLPFDDCYFDAIT 150

                          90       100
                  ....*....|....*....|....*
gi 1149726757 250 AGAAIHCWPSPSNAIAEISRVLKPG 274
Cdd:PLN02233  151 MGYGLRNVVDRLKAMQEMYRVLKPG 175
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 179-283 8.00e-09

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 55.53  E-value: 8.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 179 DVSCGSGLFSRKFASSGaySAVIALDFSENMLRQCydyiRQEETPMNtnlaLVRADISRLPFASCSIDAIHAGAAIHCWP 258
Cdd:PRK10258   48 DAGCGPGWMSRYWRERG--SQVTALDLSPPMLAQA----RQKDAADH----YLAGDIESLPLATATFDLAWSNLAVQWCG 117

                          90       100
                  ....*....|....*....|....*
gi 1149726757 259 SPSNAIAEISRVLKPGGVFVATTFL 283
Cdd:PRK10258  118 NLSTALRELYRVVRPGGVVAFTTLV 142
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 169-332 4.69e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 48.96  E-value: 4.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 169 FKPVAGGILVDVSCGSGLFSRKFASSGAysAVIALDFSENMLRQCYDYIRQEetPMNTNLALVRADisrlpfascSIDAI 248
Cdd:pfam13489  18 PKLPSPGRVLDFGCGTGIFLRLLRAQGF--SVTGVDPSPIAIERALLNVRFD--QFDEQEAAVPAG---------KFDVI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 249 HAGAAIHCWPSPSNAIAEISRVLKPGGVFvattFLSTPTNSGpfsiDALRPLRQIVGPVNSS--YNFFTEGELKDLCISC 326
Cdd:pfam13489  85 VAREVLEHVPDPPALLRQIAALLKPGGLL----LLSTPLASD----EADRLLLEWPYLRPRNghISLFSARSLKRLLEEA 156


                  ....*.
gi 1149726757 327 GLVNYS 332
Cdd:pfam13489 157 GFEVVS 162
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
231-314 7.86e-06

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 45.63  E-value: 7.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 231 VRADIS-RLPFASCSIDAIHAGaaiHCW-----PSPSNAIAEISRVLKPGGVF-VATTFLSTPTNSGPFSIDALRPLRQI 303
Cdd:COG4627    32 IVGDLTdPLPFPDNSVDAIYSS---HVLehldyEEAPLALKECYRVLKPGGILrIVVPDLEHVARLYLAEYDAALDVAEL 108

                          90
                  ....*....|.
gi 1149726757 304 VGPVNSSYNFF 314
Cdd:COG4627   109 RLAGPIDPLGI 119
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 173-302 9.10e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 45.32  E-value: 9.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 173 AGGILVDVSCGSGLFSRKFASSGAYsaVIALDFSENMLRQCydyirqeetpmNTNLA--------LVRADISRLPFASCS 244
Cdd:COG1041    26 EGDTVLDPFCGTGTILIEAGLLGRR--VIGSDIDPKMVEGA-----------RENLEhygyedadVIRGDARDLPLADES 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1149726757 245 IDAI--HA--GAAIHCWPSP-----SNAIAEISRVLKPGG--VFVATTFLSTPTNSGPFSIDALRPLRQ 302
Cdd:COG1041    93 VDAIvtDPpyGRSSKISGEEllelyEKALEEAARVLKPGGrvVIVTPRDIDELLEEAGFKVLERHEQRV 161
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 173-281 1.42e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.54  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 173 AGGILVDVSCGSGLFSRKFASsgAYSA-VIALDFSENMLrqcyDYIRQ--EETPMNTNLALVRADISRLPFAScSIDAIH 249
Cdd:COG2230    51 PGMRVLDIGCGWGGLALYLAR--RYGVrVTGVTLSPEQL----EYAREraAEAGLADRVEVRLADYRDLPADG-QFDAIV 123

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1149726757 250 AGAAIHCWPSP--SNAIAEISRVLKPGGVFVATT 281
Cdd:COG2230   124 SIGMFEHVGPEnyPAYFAKVARLLKPGGRLLLHT 157
arsM PRK11873
arsenite methyltransferase;
173-278 2.89e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 44.94  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 173 AGGILVDVSCGSG----LFSRKFASSGAysaVIALDFSENML-------RQcYDYirqeetpmnTNLALVRADISRLPFA 241
Cdd:PRK11873   77 PGETVLDLGSGGGfdcfLAARRVGPTGK---VIGVDMTPEMLakaranaRK-AGY---------TNVEFRLGEIEALPVA 143

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1149726757 242 SCSIDAIHAGAAIHCWPSPSNAIAEISRVLKPGGVFV 278
Cdd:PRK11873  144 DNSVDVIISNCVINLSPDKERVFKEAFRVLKPGGRFA 180
PRK05785 PRK05785
hypothetical protein; Provisional
 175-279 7.32e-05

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 43.52  E-value: 7.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 175 GILVDVSCGSGLFSRKFASSGAYSaVIALDFSENMLRqcydyirqeetpmntnLALVRAD-----ISRLPFASCSIDAIH 249
Cdd:PRK05785   53 KKVLDVAAGKGELSYHFKKVFKYY-VVALDYAENMLK----------------MNLVADDkvvgsFEALPFRDKSFDVVM 115

                          90       100       110
                  ....*....|....*....|....*....|
gi 1149726757 250 AGAAIHCWPSPSNAIAEISRVLKPGGVFVA 279
Cdd:PRK05785  116 SSFALHASDNIEKVIAEFTRVSRKQVGFIA 145
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 147-281 7.45e-05

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 43.75  E-value: 7.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 147 RQNFNRSGF--PGRDEEFQMAQDYFKPVAGGILvDVSCGSGLFSRKFA---SSGAYSAVIALDFSENMLRqcYDYIRQEe 221
Cdd:PRK11088   58 RRAFLDAGHyqPLRDAVANLLAERLDEKATALL-DIGCGEGYYTHALAdalPEITTMQLFGLDISKVAIK--YAAKRYP- 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1149726757 222 tpmntNLALVRADISRLPFASCSIDA---IHAgaaihcwpsPSNAiAEISRVLKPGGVFVATT 281
Cdd:PRK11088  134 -----QVTFCVASSHRLPFADQSLDAiirIYA---------PCKA-EELARVVKPGGIVITVT 181
TrmB COG0220
tRNA G46 N7-methylase TrmB [Translation, ribosomal structure and biogenesis]; tRNA G46 ...
 166-280 2.01e-04

tRNA G46 N7-methylase TrmB [Translation, ribosomal structure and biogenesis]; tRNA G46 N7-methylase TrmB is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439990  Cd Length: 204  Bit Score: 42.05  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 166 QDYFKPVAGgILVDVSCGSGLFSRKFASsgAYS--AVIALDFSENMLRQCYDYIRQEETpmnTNLALVRADISRLP--FA 241
Cdd:COG0220    26 AELFGNDAP-LVLEIGFGKGEFLVELAA--ANPdiNFIGIEVHEPGVAKALKKAEEEGL---TNVRLLRGDAVELLelFP 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1149726757 242 SCSIDAIHagaaI-HC--WP----------SPSNaIAEISRVLKPGGVF-VAT 280
Cdd:COG0220   100 DGSLDRIY----LnFPdpWPkkrhhkrrlvQPEF-LALLARVLKPGGELhLAT 147
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 176-276 1.15e-03

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 40.26  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149726757 176 ILVDVSCGSGlfsrkFASSGAYSAVIA-----LDFSENMLRQCydyirQEETPMNtNLALVRADISRLPFASCSIDAIHA 250
Cdd:PLN02490  116 KVVDVGGGTG-----FTTLGIVKHVDAknvtiLDQSPHQLAKA-----KQKEPLK-ECKIIEGDAEDLPFPTDYADRYVS 184

                          90       100
                  ....*....|....*....|....*.
gi 1149726757 251 GAAIHCWPSPSNAIAEISRVLKPGGV 276
Cdd:PLN02490  185 AGSIEYWPDPQRGIKEAYRVLKIGGK 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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