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Conserved domains on  [gi|114794927|gb|ABI79010|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Neotrichobius n. sp. GMB-2006]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-161 5.83e-44

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 147.66  E-value: 5.83e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   1 MMNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNK-LMSSEASLKYFLIQTFASSMMLMSMILVMN 79
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKnLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  80 NEFIFMK---SLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMISYSMVNNILYFSIILSAIIGAMG 156
Cdd:MTH00160  81 NLMLFNNissMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGAIG 160


                 ....*
gi 114794927 157 GLNQT 161
Cdd:MTH00160 161 GLNQT 165
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-161 5.83e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 147.66  E-value: 5.83e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   1 MMNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNK-LMSSEASLKYFLIQTFASSMMLMSMILVMN 79
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKnLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  80 NEFIFMK---SLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMISYSMVNNILYFSIILSAIIGAMG 156
Cdd:MTH00160  81 NLMLFNNissMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGAIG 160


                 ....*
gi 114794927 157 GLNQT 161
Cdd:MTH00160 161 GLNQT 165
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-161 1.04e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 58.48  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   24 SNSWITMWMGLEINLLSFIPLMSNNK--LMSSEASLKYFLIQTFASSMMLMSMILVMN--------------------NE 81
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGksPRSSEAGMKYFLLTLLGSSILLFGISLMYNytgtlsfdelskaltgglnsSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   82 FIFMKSLILMSLLLKMGASPFHFWLPIVIEGLNW-NNALLLMSWQKIAPMI--------MISYSMVNNILYFSIILSAII 152
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTpVSALLAATLVKAGGYGlirrsllyLPSSPFIQQILLILAIISMLL 160


                  ....*....
gi 114794927  153 GAMGGLNQT 161
Cdd:pfam00361 161 GSLAALVQT 169
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 10-161 3.90e-10

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 57.05  E-value: 3.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  10 FMFILMIST---IFIISSNSWITMWMGLEINLLSFIPL--MSNNKLMSSEASLKYFLIQTFASSMMLMSMILV------- 77
Cdd:COG1007  104 FYALLLFATlgmMLMASANDLLTLFLGLELLSLSLYVLvaFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLygatgsl 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  78 ------------MNNEFIFMKSLILM--SLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMI---------- 133
Cdd:COG1007  184 nlagiaaalaagGANSPLLLLGLVLVlaGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALlrllveafpg 263

                        170       180
                 ....*....|....*....|....*...
gi 114794927 134 SYSMVNNILYFSIILSAIIGAMGGLNQT 161
Cdd:COG1007  264 LAADWQLLLAVLAVLSMTVGNLAALAQT 291
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 9-161 1.00e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 49.95  E-value: 1.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927    9 IFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMS--NNKLMSSEASLKYFLIQTFASSMMLMSMILVM-------- 78
Cdd:TIGR01770 106 ILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGlkRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYgftgslnf 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   79 -------------NNEFIFMKSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIA---PMIMISYSM----- 137
Cdd:TIGR01770 186 edlllflsngmlnISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYIlfgfs 265

                         170       180
                  ....*....|....*....|....*.
gi 114794927  138 --VNNILYFSIILSAIIGAMGGLNQT 161
Cdd:TIGR01770 266 eaWQIFLAIIAFLSMLIGNFGALAQK 291
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-161 5.83e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 147.66  E-value: 5.83e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   1 MMNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNK-LMSSEASLKYFLIQTFASSMMLMSMILVMN 79
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKnLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  80 NEFIFMK---SLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMISYSMVNNILYFSIILSAIIGAMG 156
Cdd:MTH00160  81 NLMLFNNissMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGAIG 160


                 ....*
gi 114794927 157 GLNQT 161
Cdd:MTH00160 161 GLNQT 165
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 2-161 3.21e-29

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 109.14  E-value: 3.21e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   2 MNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNKL-MSSEASLKYFLIQTFASSMMLMSM------ 74
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHpRATEAATKYFLTQAAASALILFSSttnawn 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  75 -----ILVMNNEFIFMksLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMI---MISYSMVNNILYFSI 146
Cdd:MTH00112  81 tgqwdITQLTNPTSCT--LLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTlllMTSNSLNPTLLLTLA 158

                        170
                 ....*....|....*
gi 114794927 147 ILSAIIGAMGGLNQT 161
Cdd:MTH00112 159 ILSTLIGGWGGLNQT 173
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 2-161 9.58e-27

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 102.62  E-value: 9.58e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   2 MNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNKLM-SSEASLKYFLIQTFASSMMLMSMI--LVM 78
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPrSTEAATKYFLTQATASMLLMMAIIinLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  79 NNEFIFMK-------SLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAP---MIMISYSMVNNILYFSIIL 148
Cdd:MTH00105  81 SGQWTITKltnptasTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPlsiLYQISPSINPNLLLTLAIL 160

                        170
                 ....*....|...
gi 114794927 149 SAIIGAMGGLNQT 161
Cdd:MTH00105 161 SILIGGWGGLNQT 173
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 2-161 3.62e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 98.03  E-value: 3.62e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   2 MNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNKLMS-SEASLKYFLIQTFASSMMLMSMILVMNN 80
Cdd:MTH00144   1 MSSPSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSeSESVVKYFIIQSLGSSLLIFGSLIMYNL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  81 EFI-FMKSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMISYSMVNN----ILYFSIILSAIIGAM 155
Cdd:MTH00144  81 SFSwFSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYwlayLLCVISVLSALVGSI 160


                 ....*.
gi 114794927 156 GGLNQT 161
Cdd:MTH00144 161 GGLNQT 166
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 2-161 8.22e-25

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 97.69  E-value: 8.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   2 MNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNN-KLMSSEASLKYFLIQTFASSMMLMSMI----- 75
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNfSPRSVEATIKYFLVQAFSAAILLNGALiqawl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  76 ----LVMNNEFIFMKSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMISY---SMVNNILYFSIIL 148
Cdd:MTH00041  81 sgswSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISisnLLNSNILILCGIL 160

                        170
                 ....*....|...
gi 114794927 149 SAIIGAMGGLNQT 161
Cdd:MTH00041 161 SVLVGGWGGLNQT 173
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 2-161 4.37e-24

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 95.76  E-value: 4.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   2 MNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNKL-MSSEASLKYFLIQTFASSMMLMSMIL---- 76
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHpRATEAATKYFLTQASASALILFSSTInawf 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  77 -----VMNNEFIFMKSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPM---IMISYSMVNNILYFSIIL 148
Cdd:MTH00070  81 tgewtIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMallIQISHLLNSNLLIIMGLL 160

                        170
                 ....*....|...
gi 114794927 149 SAIIGAMGGLNQT 161
Cdd:MTH00070 161 STLIGGWGGLNQT 173
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 9-161 1.16e-23

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 94.49  E-value: 1.16e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   9 IFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNN-KLMSSEASLKYFLIQTFASSMMLMS-----------MIL 76
Cdd:MTH00135   8 ILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHhHPRAVEATTKYFLTQATAAAMILFAsttnawltgqwDIQ 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  77 VMNNEFIfmKSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMISYSMVNN--ILYFSIILSAIIGA 154
Cdd:MTH00135  88 QMSHPLP--TTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNptLLITLGLTSTLVGG 165


                 ....*..
gi 114794927 155 MGGLNQT 161
Cdd:MTH00135 166 WGGLNQT 172
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 9-161 1.35e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 85.88  E-value: 1.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   9 IFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNKLMS-SEASLKYFLIQTFASSMMLMSMILVMNNEFIFMKS 87
Cdd:MTH00197   2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITeNEGAMKYFLFQEFGSALLLMGGSLSFSNLYLSLLS 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114794927  88 --LILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMISYSMVNNI-LYFSIILSAIIGAMGGLNQT 161
Cdd:MTH00197  82 vvLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMgLLICSVLSSLIGGIGGMNQS 158
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 2-161 1.93e-19

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 83.09  E-value: 1.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   2 MNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNK-LMSSEASLKYFLIQTFASSMMLMSMILVMNN 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHhPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  81 EFIF---------MKSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIM---ISYSMVNNILYFSIIL 148
Cdd:MTH00200  81 SGQWgisemlgplSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALliqLAPALNSNILLLLGLL 160

                        170
                 ....*....|...
gi 114794927 149 SAIIGAMGGLNQT 161
Cdd:MTH00200 161 SVLVGGWGGLNQT 173
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-161 2.98e-17

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 76.74  E-value: 2.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   1 MMNNSSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNKL-MSSEASLKYFLIQTFASSMMLMSMILVMN 79
Cdd:MTH00011   2 MSTFPTMFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMnQESEAAVKYFLAQALGSGLLLLGMTMMWS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  80 NE---FIFMKSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMISYSMVNNILYFSIIL---SAIIG 153
Cdd:MTH00011  82 FPsllKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMaamSALAG 161


                 ....*...
gi 114794927 154 AMGGLNQT 161
Cdd:MTH00011 162 GLGGMNQT 169
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 16-161 7.72e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 64.67  E-value: 7.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  16 ISTIFIISSNSWITMWMGLEINLLSFIPLMSNNK--LMSSEASLKYFLIQTFASSMMLMSMIL---------------VM 78
Cdd:MTH00196   4 LGILCLISSSNWLSVYLAIELQTLSLFILIAQNRgsGYSAEAGLKYFVLGALSSGLFLFGCALlcgttgglhlsyinlVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  79 NNEFIFM-------KSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPM-IMISYSMVNNILYFSIILSA 150
Cdd:MTH00196  84 NSGQSFSsvsvpigYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFsILVSIGLNVNILLIGGLFSL 163

                        170
                 ....*....|.
gi 114794927 151 IIGAMGGLNQT 161
Cdd:MTH00196 164 FVGAIGALNQT 174
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 5-161 1.73e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 63.88  E-value: 1.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   5 SSKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPL--MSNNKLMSSEASLKYFLIQTFASSMMLMSMILVM---- 78
Cdd:MTH00199  97 QSSPILILIVALGSLLLVSSINWLSIYLAIELQTLTLFILvaLKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYgltg 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  79 ------NNEFIFM---KSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPM-IMISYSMVNNILYFSIIL 148
Cdd:MTH00199 177 etsiqgINSILTGdvgKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFsILVQIGPVTNVVLICAVL 256

                        170
                 ....*....|...
gi 114794927 149 SAIIGAMGGLNQT 161
Cdd:MTH00199 257 SIIYGAIGALNQT 269
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
19-161 9.85e-12

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 61.76  E-value: 9.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  19 IFIISSNSWITMWMGLEINLLSFIPL--MSNNKLMSSEASLKYFLIQTFASSMMLMSMILV------------------- 77
Cdd:PRK05777 117 MVMVSANDLLTLFLGLELLSLPLYALaaLRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLygatgslsfagiakaladg 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  78 --MNNEFIFMKSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMI----------SYSMVNNILYFS 145
Cdd:PRK05777 197 sgNSLLLLFGLVFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLlrllvvafggLSEDWQQVLAII 276

                        170
                 ....*....|....*.
gi 114794927 146 IILSAIIGAMGGLNQT 161
Cdd:PRK05777 277 AIASMLVGNLAALSQT 292
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-161 1.04e-10

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 58.48  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   24 SNSWITMWMGLEINLLSFIPLMSNNK--LMSSEASLKYFLIQTFASSMMLMSMILVMN--------------------NE 81
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGksPRSSEAGMKYFLLTLLGSSILLFGISLMYNytgtlsfdelskaltgglnsSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   82 FIFMKSLILMSLLLKMGASPFHFWLPIVIEGLNW-NNALLLMSWQKIAPMI--------MISYSMVNNILYFSIILSAII 152
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTpVSALLAATLVKAGGYGlirrsllyLPSSPFIQQILLILAIISMLL 160


                  ....*....
gi 114794927  153 GAMGGLNQT 161
Cdd:pfam00361 161 GSLAALVQT 169
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 10-161 3.90e-10

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 57.05  E-value: 3.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  10 FMFILMIST---IFIISSNSWITMWMGLEINLLSFIPL--MSNNKLMSSEASLKYFLIQTFASSMMLMSMILV------- 77
Cdd:COG1007  104 FYALLLFATlgmMLMASANDLLTLFLGLELLSLSLYVLvaFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLygatgsl 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  78 ------------MNNEFIFMKSLILM--SLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIMI---------- 133
Cdd:COG1007  184 nlagiaaalaagGANSPLLLLGLVLVlaGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALlrllveafpg 263

                        170       180
                 ....*....|....*....|....*...
gi 114794927 134 SYSMVNNILYFSIILSAIIGAMGGLNQT 161
Cdd:COG1007  264 LAADWQLLLAVLAVLSMTVGNLAALAQT 291
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 9-161 1.00e-07

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 49.95  E-value: 1.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927    9 IFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMS--NNKLMSSEASLKYFLIQTFASSMMLMSMILVM-------- 78
Cdd:TIGR01770 106 ILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGlkRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYgftgslnf 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   79 -------------NNEFIFMKSLILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIA---PMIMISYSM----- 137
Cdd:TIGR01770 186 edlllflsngmlnISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYIlfgfs 265

                         170       180
                  ....*....|....*....|....*.
gi 114794927  138 --VNNILYFSIILSAIIGAMGGLNQT 161
Cdd:TIGR01770 266 eaWQIFLAIIAFLSMLIGNFGALAQK 291
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 6-161 1.76e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 46.39  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927   6 SKLIFMFILMISTIFIISSNSWITMWMGLEINLLSFIPLMSNNKLMSS----------EASLKYFLIQTFASSMML---- 71
Cdd:MTH00198 189 SGFALVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGShfpspgntppESGLKYWILGAMSSGFYLfgca 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  72 ---------------MSMILVMNNEFIFMKSL----ILMSLLLKMGASPFHFWLPIVIEGLNWNNALLLMSWQKIAPMIM 132
Cdd:MTH00198 269 lyfgftgnegmlgtiLSATLETTNIELRQGSLgylfITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYIL 348

                        170       180       190
                 ....*....|....*....|....*....|
gi 114794927 133 ISYSMVNNILYFSI-ILSAIIGAMGGLNQT 161
Cdd:MTH00198 349 LTSLVITSKLLLSVaIISLVVGAFGALNQT 378
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 10-107 4.41e-03

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 36.28  E-value: 4.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794927  10 FMFILMISTIFIISSNSWITMWMGLEINLL-SFIPLMSNNKLMSSEASLKYFLIQTFASSMMLMSMILVMNN-------- 80
Cdd:COG0651  112 LFLLLLAGMNGAFLTGDLFNLFVFFEVMLLaSYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGAtgtlnmad 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 114794927  81 -------------EFIFMksLILMSLLLKMGASPFHFWLP 107
Cdd:COG0651  192 laarlaeldpgllLAAFA--LLLVGFGIKAALFPLHFWLP 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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