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Conserved domains on  [gi|114794907|gb|ABI79000|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Speiseria ambigua]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-162 5.56e-41

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 139.96  E-value: 5.56e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   1 MFNNSYKFIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNK-LMSSEASLKYFLIQTFA---SSILLLSIIL 76
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKnLMSSESSLKYFLIQALAsiiLLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  77 IMNNQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMMISYSSINHMMYISIIFSAMIGAIG 156
Cdd:MTH00160  81 NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGAIG 160


                 ....*.
gi 114794907 157 GLNQTS 162
Cdd:MTH00160 161 GLNQTS 166
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-162 5.56e-41

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 139.96  E-value: 5.56e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   1 MFNNSYKFIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNK-LMSSEASLKYFLIQTFA---SSILLLSIIL 76
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKnLMSSESSLKYFLIQALAsiiLLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  77 IMNNQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMMISYSSINHMMYISIIFSAMIGAIG 156
Cdd:MTH00160  81 NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGAIG 160


                 ....*.
gi 114794907 157 GLNQTS 162
Cdd:MTH00160 161 GLNQTS 166
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-162 7.25e-09

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 53.09  E-value: 7.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   24 SNSWITMWMGLEMNLLAFIPLMSNNK--LMSSEASLKYFLIQTFASSI--------------------LLLSIILIMNNQ 81
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGksPRSSEAGMKYFLLTLLGSSIllfgislmynytgtlsfdelSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   82 FSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNS-LMLMTWQKIAPM--------MMISYSSINHMMYISIIFSAMI 152
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSaLLAATLVKAGGYglirrsllYLPSSPFIQQILLILAIISMLL 160

                         170
                  ....*....|
gi 114794907  153 GAIGGLNQTS 162
Cdd:pfam00361 161 GSLAALVQTD 170
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 3-162 5.68e-06

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 45.11  E-value: 5.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   3 NNSYKFIFIMILMFST---IFIISSNSWITMWMGLEMNLLAFIPL--MSNNKLMSSEASLKYFLIQTFA----------- 66
Cdd:COG1007   97 RGLLRGEFYALLLFATlgmMLMASANDLLTLFLGLELLSLSLYVLvaFRRDDRRSSEAALKYFLLGALSsgfllygisll 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  67 ----------SSILLLSIILIMNNQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPM------ 130
Cdd:COG1007  177 ygatgslnlaGIAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFaallrl 256

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 114794907 131 MMISYSSINH----MMYISIIFSAMIGAIGGLNQTS 162
Cdd:COG1007  257 LVEAFPGLAAdwqlLLAVLAVLSMTVGNLAALAQTN 292
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 2-162 1.00e-05

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 44.17  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907    2 FNNSYKFIFIMILMFSTI---FIISSNSWITMWMGLEMNLLAFIPLMS--NNKLMSSEASLKYFLIQTFAS--------- 67
Cdd:TIGR01770  96 KEKINKFEFYILLLFALLgifLLVSSNDLLSIYLGLELQSLCFYVLAGlkRKSRFSTEAGLKYFILGAFSSglllfgisl 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   68 ------------SILLLSIILIMNNQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIA---PMMM 132
Cdd:TIGR01770 176 iygftgslnfedLLLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLR 255

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 114794907  133 ISYSSI-------NHMMYISIIFSAMIGAIGGLNQTS 162
Cdd:TIGR01770 256 LFLYILfgfseawQIFLAIIAFLSMLIGNFGALAQKK 292
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-162 5.56e-41

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 139.96  E-value: 5.56e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   1 MFNNSYKFIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNK-LMSSEASLKYFLIQTFA---SSILLLSIIL 76
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKnLMSSESSLKYFLIQALAsiiLLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  77 IMNNQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMMISYSSINHMMYISIIFSAMIGAIG 156
Cdd:MTH00160  81 NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGAIG 160


                 ....*.
gi 114794907 157 GLNQTS 162
Cdd:MTH00160 161 GLNQTS 166
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 4-161 4.11e-26

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 101.08  E-value: 4.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   4 NSYKFIFIMILMFS-TIFIISSNSWITMWMGLEMNLLAFIPLMSNNKLM-SSEASLKYFLIQTFASSILLL--SIILIMN 79
Cdd:MTH00105   2 NPLILIIIYLTLFLgTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPrSTEAATKYFLTQATASMLLMMaiIINLMYS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  80 NQFSFMNL-------LITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPM--MMISYSSIN-HMMYISIIFS 149
Cdd:MTH00105  82 GQWTITKLtnptastLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLsiLYQISPSINpNLLLTLAILS 161

                        170
                 ....*....|..
gi 114794907 150 AMIGAIGGLNQT 161
Cdd:MTH00105 162 ILIGGWGGLNQT 173
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 7-161 2.37e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 99.13  E-value: 2.37e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   7 KFIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNKL-MSSEASLKYFLIQTFASSILLLSIIL--------- 76
Cdd:MTH00112   6 KLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHpRATEAATKYFLTQAAASALILFSSTTnawntgqwd 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  77 --IMNNQFSfmNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPM--MMISYSSINHMMYISI-IFSAM 151
Cdd:MTH00112  86 itQLTNPTS--CTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLtlLLMTSNSLNPTLLLTLaILSTL 163

                        170
                 ....*....|
gi 114794907 152 IGAIGGLNQT 161
Cdd:MTH00112 164 IGGWGGLNQT 173
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 8-162 1.12e-23

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 94.61  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   8 FIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNN-KLMSSEASLKYFLIQTF--ASSILLLSIILIMNNQFS- 83
Cdd:MTH00041   7 IFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNfSPRSVEATIKYFLVQAFsaAILLNGALIQAWLSGSWSi 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  84 ------FMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMMISYSSINHMMYISI---IFSAMIGA 154
Cdd:MTH00041  87 ngplntLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILIlcgILSVLVGG 166


                 ....*...
gi 114794907 155 IGGLNQTS 162
Cdd:MTH00041 167 WGGLNQTQ 174
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 11-161 1.38e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 91.40  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  11 IMILMFS----TIFIISSNSWITMWMGLEMNLLAFIPLMSNN-KLMSSEASLKYFLIQT-------FASSILLLSIILIM 78
Cdd:MTH00135   6 LTILLFSlglgTTLTFASSHWLLAWMGLEINTLAIIPLMAQHhHPRAVEATTKYFLTQAtaaamilFASTTNAWLTGQWD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  79 NNQFS--FMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPM-MMISYSSINHMMYISI-IFSAMIGA 154
Cdd:MTH00135  86 IQQMShpLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFaLILQIAPTNPTLLITLgLTSTLVGG 165


                 ....*..
gi 114794907 155 IGGLNQT 161
Cdd:MTH00135 166 WGGLNQT 172
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 5-162 3.28e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 90.33  E-value: 3.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   5 SYKFIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNKLMS-SEASLKYFLIQTFASSILLLSIILIMNNQFS 83
Cdd:MTH00144   4 PSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSeSESVVKYFIIQSLGSSLLIFGSLIMYNLSFS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  84 -FMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMMISYSSINH----MMYISIIFSAMIGAIGGL 158
Cdd:MTH00144  84 wFSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYwlayLLCVISVLSALVGSIGGL 163


                 ....
gi 114794907 159 NQTS 162
Cdd:MTH00144 164 NQTQ 167
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 8-161 1.77e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 88.44  E-value: 1.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   8 FIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNKL-MSSEASLKYFLIQTFASSILLLSIIL---------I 77
Cdd:MTH00070   7 SILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHpRATEAATKYFLTQASASALILFSSTInawftgewtI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  78 MNNQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMM---MISYSSINHMMYISIIFSAMIGA 154
Cdd:MTH00070  87 MNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMAlliQISHLLNSNLLIIMGLLSTLIGG 166


                 ....*..
gi 114794907 155 IGGLNQT 161
Cdd:MTH00070 167 WGGLNQT 173
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 8-162 3.55e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 87.42  E-value: 3.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   8 FIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNKLMS-SEASLKYFLIQTFASSILLLSIILIMNN--QFSF 84
Cdd:MTH00197   1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITeNEGAMKYFLFQEFGSALLLMGGSLSFSNlyLSLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114794907  85 MNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMMISYSSINHMM-YISIIFSAMIGAIGGLNQTS 162
Cdd:MTH00197  81 SVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGlLICSVLSSLIGGIGGMNQSN 159
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 9-161 1.44e-18

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 80.78  E-value: 1.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   9 IFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNK-LMSSEASLKYFLIQTFASSILLLSIILIMNNQF----- 82
Cdd:MTH00200   8 LFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHhPRKVEATTKYFIIQATASALLLFGGLLNAWTSGqwgis 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  83 ----SFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMM---ISYSSINHMMYISIIFSAMIGAI 155
Cdd:MTH00200  88 emlgPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALliqLAPALNSNILLLLGLLSVLVGGW 167


                 ....*.
gi 114794907 156 GGLNQT 161
Cdd:MTH00200 168 GGLNQT 173
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 6-161 3.53e-15

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 71.35  E-value: 3.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   6 YKFIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNKL-MSSEASLKYFLIQTFA---SSILLLSIILIMNNQ 81
Cdd:MTH00011   7 TMFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMnQESEAAVKYFLAQALGsglLLLGMTMMWSFPSLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  82 FSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMMISY---SSINHMMYISIIFSAMIGAIGGL 158
Cdd:MTH00011  87 KNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFftsHNILPMMTSMAAMSALAGGLGGM 166


                 ...
gi 114794907 159 NQT 161
Cdd:MTH00011 167 NQT 169
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 16-161 9.16e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 61.58  E-value: 9.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  16 FSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNK--LMSSEASLKYF---------------LIQTFASSILLLSIILIM 78
Cdd:MTH00196   4 LGILCLISSSNWLSVYLAIELQTLSLFILIAQNRgsGYSAEAGLKYFvlgalssglflfgcaLLCGTTGGLHLSYINLVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  79 NNQFSFM-------NLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPM-MMISYSSINHMMYISIIFSA 150
Cdd:MTH00196  84 NSGQSFSsvsvpigYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFsILVSIGLNVNILLIGGLFSL 163

                        170
                 ....*....|.
gi 114794907 151 MIGAIGGLNQT 161
Cdd:MTH00196 164 FVGAIGALNQT 174
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 9-162 1.07e-10

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 58.87  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   9 IFIMILMFSTIFIISSNSWITMWMGLEM-NLLAFIPL-MSNNKLMSSEASLKYFLIQTFASSILLL----------SIIL 76
Cdd:MTH00199 101 ILILIVALGSLLLVSSINWLSIYLAIELqTLTLFILVaLKRDSAYSTEAGLKYFVLGAVSSGLFLFgcallygltgETSI 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  77 IMNNQFSFMN---LLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPM-MMISYSSINHMMYISIIFSAMI 152
Cdd:MTH00199 181 QGINSILTGDvgkILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFsILVQIGPVTNVVLICAVLSIIY 260

                        170
                 ....*....|
gi 114794907 153 GAIGGLNQTS 162
Cdd:MTH00199 261 GAIGALNQTK 270
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-162 7.25e-09

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 53.09  E-value: 7.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   24 SNSWITMWMGLEMNLLAFIPLMSNNK--LMSSEASLKYFLIQTFASSI--------------------LLLSIILIMNNQ 81
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGksPRSSEAGMKYFLLTLLGSSIllfgislmynytgtlsfdelSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   82 FSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNS-LMLMTWQKIAPM--------MMISYSSINHMMYISIIFSAMI 152
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSaLLAATLVKAGGYglirrsllYLPSSPFIQQILLILAIISMLL 160

                         170
                  ....*....|
gi 114794907  153 GAIGGLNQTS 162
Cdd:pfam00361 161 GSLAALVQTD 170
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
7-162 9.31e-07

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 47.12  E-value: 9.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   7 KFIFIMILMFST---IFIISSNSWITMWMGLEMNLLAFIPL--MSNNKLMSSEASLKYFLI------------------- 62
Cdd:PRK05777 102 RGEFYLLVLFALlgmMVMVSANDLLTLFLGLELLSLPLYALaaLRRDRRRSLEAAIKYFVLgalasgfllygmsllygat 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  63 --QTFASSILLLSIILIMNNQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMMI------- 133
Cdd:PRK05777 182 gsLSFAGIAKALADGSGNSLLLLFGLVFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLlrllvva 261

                        170       180       190
                 ....*....|....*....|....*....|..
gi 114794907 134 ---SYSSINHMMYISIIFSAMIGAIGGLNQTS 162
Cdd:PRK05777 262 fggLSEDWQQVLAIIAIASMLVGNLAALSQTN 293
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 8-161 5.02e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 45.23  E-value: 5.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   8 FIFIMILMFSTIFIISSNSWITMWMGLEMNLLAFIPLMSNNKLMSS----------EASLKYFLIQTFASSILLLSIILI 77
Cdd:MTH00198 191 FALVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGShfpspgntppESGLKYWILGAMSSGFYLFGCALY 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  78 MN-----------------------NQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPMMMIS 134
Cdd:MTH00198 271 FGftgnegmlgtilsatlettnielRQGSLGYLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLT 350

                        170       180
                 ....*....|....*....|....*...
gi 114794907 135 YSSINHMMYISI-IFSAMIGAIGGLNQT 161
Cdd:MTH00198 351 SLVITSKLLLSVaIISLVVGAFGALNQT 378
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 3-162 5.68e-06

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 45.11  E-value: 5.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   3 NNSYKFIFIMILMFST---IFIISSNSWITMWMGLEMNLLAFIPL--MSNNKLMSSEASLKYFLIQTFA----------- 66
Cdd:COG1007   97 RGLLRGEFYALLLFATlgmMLMASANDLLTLFLGLELLSLSLYVLvaFRRDDRRSSEAALKYFLLGALSsgfllygisll 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907  67 ----------SSILLLSIILIMNNQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIAPM------ 130
Cdd:COG1007  177 ygatgslnlaGIAAALAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFaallrl 256

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 114794907 131 MMISYSSINH----MMYISIIFSAMIGAIGGLNQTS 162
Cdd:COG1007  257 LVEAFPGLAAdwqlLLAVLAVLSMTVGNLAALAQTN 292
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 2-162 1.00e-05

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 44.17  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907    2 FNNSYKFIFIMILMFSTI---FIISSNSWITMWMGLEMNLLAFIPLMS--NNKLMSSEASLKYFLIQTFAS--------- 67
Cdd:TIGR01770  96 KEKINKFEFYILLLFALLgifLLVSSNDLLSIYLGLELQSLCFYVLAGlkRKSRFSTEAGLKYFILGAFSSglllfgisl 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114794907   68 ------------SILLLSIILIMNNQFSFMNLLITMSLLLKMGASPFHFWFPIVIEGLSWNNSLMLMTWQKIA---PMMM 132
Cdd:TIGR01770 176 iygftgslnfedLLLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLR 255

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 114794907  133 ISYSSI-------NHMMYISIIFSAMIGAIGGLNQTS 162
Cdd:TIGR01770 256 LFLYILfgfseawQIFLAIIAFLSMLIGNFGALAQKK 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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