|
Name |
Accession |
Description |
Interval |
E-value |
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
16-332 |
3.45e-159 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 448.97 E-value: 3.45e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 16 IAAYRDRLPVgDDWTPVTLLEGGTPLIAATNLSK-QTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTG 94
Cdd:cd01563 1 LWRYRELLPV-TEDDIVSLGEGNTPLVRAPRLGErLGGKNLYVKDEGLNPTGSFKDRGMTVAVSKAKELGVKAVACASTG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 95 NTSASAAAYAARAGITCAVLIPQGKiAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPtISLVNSVNPVRIEGQK 174
Cdd:cd01563 80 NTSASLAAYAARAGIKCVVFLPAGK-ALGKLAQALAYGATVLAVEGNFDDALRLVRELAEENW-IYLSNSLNPYRLEGQK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 175 TAAFEIVDVLG-TAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLG--------EPVSHPET 245
Cdd:cd01563 158 TIAFEIAEQLGwEVPDYVVVPVGNGGNITAIWKGFKELKELGLIDRLPRMVGVQAEGAAPIVRAfkegkddiEPVENPET 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 246 IATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCTV 325
Cdd:cd01563 238 IATAIRIGNPASGPKALRAVRESGGTAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGLKKLREEGIIDKGERVVVVL 317
|
....*..
gi 114793663 326 TGNGLKD 332
Cdd:cd01563 318 TGHGLKD 324
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
12-338 |
4.55e-138 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 398.03 E-value: 4.55e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 12 WPGvIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCA 91
Cdd:COG0498 41 RRG-LWRYRELLPFDDEEKAVSLGEGGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDRAMQVAVSLALERGAKTIVCA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 92 STGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPtISLVNSVNPVRIE 171
Cdd:COG0498 120 SSGNGSAALAAYAARAGIEVFVFVPEGKVSPGQLAQMLTYGAHVIAVDGNFDDAQRLVKELAADEG-LYAVNSINPARLE 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 172 GQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVL----GEPV---SHPE 244
Cdd:COG0498 199 GQKTYAFEIAEQLGRVPDWVVVPTGNGGNILAGYKAFKELKELGLIDRLPRLIAVQATGCNPILTafetGRDEyepERPE 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 245 TIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCT 324
Cdd:COG0498 279 TIAPSMDIGNPSNGERALFALRESGGTAVAVSDEEILEAIRLLARREGIFVEPATAVAVAGLRKLREEGEIDPDEPVVVL 358
|
330
....*....|....
gi 114793663 325 VTGNGLKDPDTALK 338
Cdd:COG0498 359 STGHGLKFPDAVRE 372
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
19-334 |
3.29e-118 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 345.14 E-value: 3.29e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 19 YRDRLPVGDDwTPVTLLEGGTPLIAATNLSKQTGCT-IHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTS 97
Cdd:TIGR00260 4 YREFLPVTEK-DLVDLGEGVTPLFRAPALAANVGIKnLYVKELGHNPTLSFKDRGMAVALTKALELGNDTVLCASTGNTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 98 ASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPtISLVNSVN--PVRIEGQKT 175
Cdd:TIGR00260 83 AAAAAYAGKAGLKVVVLYPAGKISLGKLAQALGYNAEVVAIDGNFDDAQRLVKQLFEDKP-ALGLNSANsiPYRLEGQKT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 176 AAFEIVDVLG-TAPDVHALPVGNAGNITAYWKGYTEYHQLGLiDKLPRMLGTQAAGAAPLVLG-------EPVSHPETIA 247
Cdd:TIGR00260 162 YAFEAVEQLGwEAPDKVVVPVPNSGNFGAIWKGFKEKKMLGL-DSLPVKRGIQAEGAADIVRAfleggqwEPIETPETLS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 248 TAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCTVTG 327
Cdd:TIGR00260 241 TAMDIGNPANWPRALEAFRRSNGYAEDLSDEEILEAIKLLAREEGYFVEPHSAVAVAALLKLVEKGTADPAERVVCALTG 320
|
....*..
gi 114793663 328 NGLKDPD 334
Cdd:TIGR00260 321 NGLKDPE 327
|
|
| PLN02569 |
PLN02569 |
threonine synthase |
4-331 |
3.56e-73 |
|
threonine synthase
Pssm-ID: 178182 [Multi-domain] Cd Length: 484 Bit Score: 235.09 E-value: 3.56e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 4 PPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQTGCTIHL--KVEGLNPTGSFKDRGMTMAVTDA- 80
Cdd:PLN02569 99 VGKTTWPYGSGVWSKKEWVLPEIDDDDIVSLFEGNSNLFWAERLGKEFLGMNDLwvKHCGISHTGSFKDLGMTVLVSQVn 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 81 ----LAHGQRAVLCASTGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADF 156
Cdd:PLN02569 179 rlrkMAKPVVGVGCASTGDTSAALSAYCAAAGIPSIVFLPADKISIAQLVQPIANGALVLSIDTDFDGCMRLIREVTAEL 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 157 PtISLVNSVNPVRIEGQKTAAFEIVDVLG-TAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLV 235
Cdd:PLN02569 259 P-IYLANSLNSLRLEGQKTAAIEILQQFDwEVPDWVIVPGGNLGNIYAFYKGFKMCKELGLVDRLPRLVCAQAANANPLY 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 236 LG--------EPVSHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLvARVEGVFVEPASAASIAGLL 307
Cdd:PLN02569 338 RAyksgweefKPVKANPTFASAIQIGDPVSIDRAVYALKESNGIVEEATEEELMDAQAE-ADKTGMFLCPHTGVALAALK 416
|
330 340
....*....|....*....|....
gi 114793663 308 KAIDDGWVARGSTVVCTVTGNGLK 331
Cdd:PLN02569 417 KLRASGVIGPTDRTVVVSTAHGLK 440
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
32-327 |
1.01e-66 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 212.56 E-value: 1.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 32 VTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAH-GQRAVLCASTGNTSASAAAYAARAGIT 110
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGeGGKTVVEASSGNHGRALAAAAARLGLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 111 CAVLIPQGKIAmGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSV-NPVRIEGQKTAAFEIVDVLGTAPD 189
Cdd:pfam00291 81 VTIVVPEDAPP-GKLLLMRALGAEVVLVGGDYDEAVAAARELAAEGPGAYYINQYdNPLNIEGYGTIGLEILEQLGGDPD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 190 VHALPVGNAGNITAYWKGyteyhqLGLIDKLPRMLGTQAAGAAPLVLG------EPVSHPETIATAIRIGSPASwTSAVE 263
Cdd:pfam00291 160 AVVVPVGGGGLIAGIARG------LKELGPDVRVIGVEPEGAPALARSlaagrpVPVPVADTIADGLGVGDEPG-ALALD 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 114793663 264 AQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGlLKAIDDGWVARGSTVVCTVTG 327
Cdd:pfam00291 233 LLDEYVGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAA-LKLALAGELKGGDRVVVVLTG 295
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
39-327 |
1.21e-62 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 200.05 E-value: 1.21e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRA---VLCASTGNTSASAAAYAARAGITCAVLI 115
Cdd:cd00640 1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKLPkgvIIESTGGNTGIALAAAAARLGLKCTIVM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 116 PQGKiAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNS-VNPVRIEGQKTAAFEIV-DVLGTAPDVHAL 193
Cdd:cd00640 81 PEGA-SPEKVAQMRALGAEVVLVPGDFDDAIALAKELAEEDPGAYYVNQfDNPANIAGQGTIGLEILeQLGGQKPDAVVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 194 PVGNAGNITAYWKGYTEYHqlglidKLPRMLGTQAagaaplvlgepvshpetiatairigspaswtsaveaqqqskgRFL 273
Cdd:cd00640 160 PVGGGGNIAGIARALKELL------PNVKVIGVEP------------------------------------------EVV 191
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 114793663 274 AASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGwvARGSTVVCTVTG 327
Cdd:cd00640 192 TVSDEEALEAIRLLAREEGILVEPSSAAALAAALKLAKKL--GKGKTVVVILTG 243
|
|
| PRK08197 |
PRK08197 |
threonine synthase; Validated |
19-335 |
1.21e-60 |
|
threonine synthase; Validated
Pssm-ID: 181283 [Multi-domain] Cd Length: 394 Bit Score: 199.84 E-value: 1.21e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 19 YRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQTGC-TIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTS 97
Cdd:PRK08197 60 YHELLPVRDPEHIVSLGEGMTPLLPLPRLGKALGIgRLWVKDEGLNPTGSFKARGLAVGVSRAKELGVKHLAMPTNGNAG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 98 ASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMhGAKIIQIDGNFDDCLELARKMAAD---FPTISLVNsvnPVRIEGQK 174
Cdd:PRK08197 140 AAWAAYAARAGIRATIFMPADAPEITRLECALA-GAELYLVDGLISDAGKIVAEAVAEygwFDVSTLKE---PYRIEGKK 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 175 TAAFEIVDVLG-TAPDVHALPVGNAGNITAYWKGYTEYHQLGLID-KLPRMLGTQAAGAAPLV--------LGEPVSHPE 244
Cdd:PRK08197 216 TMGLELAEQLGwRLPDVILYPTGGGVGLIGIWKAFDELEALGWIGgKRPRLVAVQAEGCAPIVkaweegkeESEFWEDAH 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 245 TIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCT 324
Cdd:PRK08197 296 TVAFGIRVPKALGDFLVLDAVRETGGCAIAVSDDAILAAQRELAREEGLFACPEGAATFAAARQLRESGWLKGDERVVLF 375
|
330
....*....|.
gi 114793663 325 VTGNGLKDPDT 335
Cdd:PRK08197 376 NTGSGLKYPDT 386
|
|
| PRK05638 |
PRK05638 |
threonine synthase; Validated |
32-333 |
1.48e-58 |
|
threonine synthase; Validated
Pssm-ID: 235539 [Multi-domain] Cd Length: 442 Bit Score: 195.80 E-value: 1.48e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 32 VTLLEGGTPLIAATNLSKqTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAAYAARAGITC 111
Cdd:PRK05638 60 ISLGEGGTPLIRARISEK-LGENVYIKDETRNPTGSFRDRLATVAVSYGLPYAANGFIVASDGNAAASVAAYSARAGKEA 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 112 AVLIPQgKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGtaPDVH 191
Cdd:PRK05638 139 FVVVPR-KVDKGKLIQMIAFGAKIIRYGESVDEAIEYAEELARLNGLYNVTPEYNIIGLEGQKTIAFELWEEIN--PTHV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 192 ALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPL---VLGEPVSHPETIATAIRIGSPASWTSAVEAQQQS 268
Cdd:PRK05638 216 IVPTGSGSYLYSIYKGFKELLEIGVIEEIPKLIAVQTERCNPIaseILGNKTKCNETKALGLYVKNPVMKEYVSEAIKES 295
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114793663 269 KGRFLAASDEEILAAYHLVARvEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDP 333
Cdd:PRK05638 296 GGTAVVVNEEEIMAGEKLLAK-EGIFAELSSAVVMPALLKLGEEGYIEKGDKVVLVVTGSGLKGY 359
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
37-327 |
1.62e-41 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 147.54 E-value: 1.62e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 37 GGTPLIAATNLSKQTGCT-IHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAAYAARAGITCAVLI 115
Cdd:PRK06381 14 GGTPLLRARKLEEELGLRkIYLKFEGANPTGTQKDRIAEAHVRRAMRLGYSGITVGTCGNYGASIAYFARLYGLKAVIFI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 116 PQGkIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADF------PtislvNSVNP-VRIEGQKTAAFEIVDVLGTAP 188
Cdd:PRK06381 94 PRS-YSNSRVKEMEKYGAEIIYVDGKYEEAVERSRKFAKENgiydanP-----GSVNSvVDIEAYSAIAYEIYEALGDVP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 189 DVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLV------LGEPVS-HPETIA-TAirIGSP-ASWT 259
Cdd:PRK06381 168 DAVAVPVGNGTTLAGIYHGFRRLYDRGKTSRMPRMIGVSTSGGNQIVesfkrgSSEVVDlEVDEIReTA--VNEPlVSYR 245
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 114793663 260 S-----AVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARgsTVVCTVTG 327
Cdd:PRK06381 246 SfdgdnALEAIYDSHGYAFGFSDDEMVKYAELLRRMEGLNALPASASALAALVKYLKKNGVND--NVVAVITG 316
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
19-331 |
1.09e-40 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 146.12 E-value: 1.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 19 YRDRLPVGDDWTPvTLLEGGTPLIaatnlskQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSA 98
Cdd:PRK08329 46 YIDYLPVDEEFLP-HLTPPITPTV-------KRSIKVYFKLDYLQPTGSFKDRGTYVTVAKLKEEGINEVVIDSSGNAAL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 99 SAAAYAARAGITCAVLIP----QGKIAMGKLAQAVMHgakiiQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQK 174
Cdd:PRK08329 118 SLALYSLSEGIKVHVFVSynasKEKISLLSRLGAELH-----FVEGDRMEVHEEAVKFSKRNNIPYVSHWLNPYFLEGTK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 175 TAAFEIVDVLGTaPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVlgePVSHPE-TIATAIRIG 253
Cdd:PRK08329 193 TIAYEIYEQIGV-PDYAFVPVGSGTLFLGIWKGFKELHEMGEISKMPKLVAVQAEGYESLC---KRSKSEnKLADGIAIP 268
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114793663 254 SPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVeGVFVEPASAASIAGLLKAIDDGWVARGSTVVCTVTGNGLK 331
Cdd:PRK08329 269 EPPRKEEMLRALEESNGFCISVGEEETRAALHWLRRM-GFLVEPTSAVALAAYWKLLEEGLIEGGSKVLLPLSGSGLK 345
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
39-327 |
2.82e-31 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 119.90 E-value: 2.82e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTdALAHGQRA--VLCASTGNTSASAAAYAARAGITCAVLIP 116
Cdd:cd01562 18 TPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLL-SLSEEERAkgVVAASAGNHAQGVAYAAKLLGIPATIVMP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 117 QGKIAMgKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDvlgTAPDVHAL--P 194
Cdd:cd01562 97 ETAPAA-KVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHPFDDPDVIAGQGTIGLEILE---QVPDLDAVfvP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 195 VGNAG---NITAYWKgyteyHQLGLIdklpRMLGTQAAGAAPLVL----GEPVSHPE--TIATAIRIGSPASWTSAVeaQ 265
Cdd:cd01562 173 VGGGGliaGIATAVK-----ALSPNT----KVIGVEPEGAPAMAQslaaGKPVTLPEvdTIADGLAVKRPGELTFEI--I 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 114793663 266 QQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDgwvARGSTVVCTVTG 327
Cdd:cd01562 242 RKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLD---LKGKKVVVVLSG 300
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
39-327 |
7.10e-30 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 116.67 E-value: 7.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVtDALAHGQRA--VLCASTGNTSASAAAYAARAGITCAVLIP 116
Cdd:COG1171 25 TPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNAL-ASLSEEERArgVVAASAGNHAQGVAYAARLLGIPATIVMP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 117 QGkIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAA--------DF--PTIslvnsvnpvrIEGQKTAAFEIVDvlgT 186
Cdd:COG1171 104 ET-APAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEeegatfvhPFddPDV----------IAGQGTIALEILE---Q 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 187 APDVHAL--PVGN----AGnITAYWKGyteyhqlglIDKLPRMLGTQAAGAAPLVL----GEPVSHPE--TIATAIRIGS 254
Cdd:COG1171 170 LPDLDAVfvPVGGggliAG-VAAALKA---------LSPDIRVIGVEPEGAAAMYRslaaGEPVTLPGvdTIADGLAVGR 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 114793663 255 PASWTSAVeAQQQSkGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDgwvARGSTVVCTVTG 327
Cdd:COG1171 240 PGELTFEI-LRDLV-DDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKER---LKGKRVVVVLSG 307
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
32-331 |
5.83e-23 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 97.88 E-value: 5.83e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 32 VTLLEGGTPLIAATNlskqtgctIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAAYAARAGITC 111
Cdd:PRK06450 52 ISLGEGRTPLIKKGN--------IWFKLDFLNPTGSYKDRGSVTLISYLAEKGIKQISEDSSGNAGASIAAYGAAAGIEV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 112 AVLIPQgKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLvnsvNPVRIEGQKTAAFEIVDVLGT-APDV 190
Cdd:PRK06450 124 KIFVPE-TASGGKLKQIESYGAEVVRVRGSREDVAKAAENSGYYYASHVL----QPQFRDGIRTLAYEIAKDLDWkIPNY 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 191 HALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPL---VLGEPVSHPE---TIATAIRIGSPASWTSAVEA 264
Cdd:PRK06450 199 VFIPVSAGTLLLGVYSGFKHLLDSGVISEMPKIVAVQTEQVSPLcakFKGISYTPPDkvtSIADALVSTRPFLLDYMVKA 278
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114793663 265 QQQSkGRFLAASDEEILAAYHLVARvEGVFVEPASAASIAGLLKaiddgWVARGSTVVctVTGNGLK 331
Cdd:PRK06450 279 LSEY-GECIVVSDNEIVEAWKELAK-KGLLVEYSSATVYAAYKK-----YSVNDSVLV--LTGSGLK 336
|
|
| PRK08639 |
PRK08639 |
threonine dehydratase; Validated |
39-327 |
2.16e-20 |
|
threonine dehydratase; Validated
Pssm-ID: 236318 [Multi-domain] Cd Length: 420 Bit Score: 91.41 E-value: 2.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVtDALAHGQRA--VLCASTGNtsasaaayaARAGI--TCAVL 114
Cdd:PRK08639 26 TPLQRNDYLSEKYGANVYLKREDLQPVRSYKLRGAYNAI-SQLSDEELAagVVCASAGN---------HAQGVayACRHL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 115 IPQGKIAM------GKLAQAVMHGAK---IIQIDGNFDDCLELARKMAAD--------FPtislvnsvNPVRIEGQKTAA 177
Cdd:PRK08639 96 GIPGVIFMpvttpqQKIDQVRFFGGEfveIVLVGDTFDDSAAAAQEYAEEtgatfippFD--------DPDVIAGQGTVA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 178 FEIVDVLGTA--PDVHALPVGNAG---NITAYWKGYTeyhqlglidklP--RMLGTQAAGA----APLVLGEPVSHPET- 245
Cdd:PRK08639 168 VEILEQLEKEgsPDYVFVPVGGGGlisGVTTYLKERS-----------PktKIIGVEPAGAasmkAALEAGKPVTLEKId 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 246 -----IATAiRIGS-PASWTSAVEAQqqskgrfLAASDE-----EILAAYHlvarVEGVFVEPASAASIAGLLKAIDDgw 314
Cdd:PRK08639 237 kfvdgAAVA-RVGDlTFEILKDVVDD-------VVLVPEgavctTILELYN----KEGIVAEPAGALSIAALELYKDE-- 302
|
330
....*....|...
gi 114793663 315 vARGSTVVCTVTG 327
Cdd:PRK08639 303 -IKGKTVVCVISG 314
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
37-340 |
1.46e-19 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 87.57 E-value: 1.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 37 GGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQ----RAVLCASTGNTSASAAAYAARAGITCA 112
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLlkpgTTIIEPTSGNTGIGLAMVAAAKGYRFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 113 VLIPqGKIAMGKLAQAVMHGAKIIQIDGNFDD----CLELARKMAADFPtislvNSV------NPVRIEG-QKTAAFEIV 181
Cdd:cd01561 81 IVMP-ETMSEEKRKLLRALGAEVILTPEAEADgmkgAIAKARELAAETP-----NAFwlnqfeNPANPEAhYETTAPEIW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 182 DVLGTAPDVHALPVGNAGNITaywkGYTEYhqlgLIDKLP--RMLGTQAAGAAPLVLGEPVSHpetIATAIRIGS-PASW 258
Cdd:cd01561 155 EQLDGKVDAFVAGVGTGGTIT----GVARY----LKEKNPnvRIVGVDPVGSVLFSGGPPGPH---KIEGIGAGFiPENL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 259 -TSAVEaqqqskgRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDgwVARGSTVVCTVtgnglkdPDTAL 337
Cdd:cd01561 224 dRSLID-------EVVRVSDEEAFAMARRLAREEGLLVGGSSGAAVAAALKLAKR--LGPGKTIVTIL-------PDSGE 287
|
...
gi 114793663 338 KDM 340
Cdd:cd01561 288 RYL 290
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
39-327 |
9.36e-19 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 85.51 E-value: 9.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTdALAHGQR--AVLCASTGNTSASAAAYAARAGITCAVLIP 116
Cdd:PRK06815 21 TPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKLR-LLNEAQRqqGVITASSGNHGQGVALAAKLAGIPVTVYAP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 117 QGKIAMgKLAQAVMHGAKIIQIDgnfDDCLEL---ARKMAAD--FPTISLVNsvNPVRIEGQKTAAFEIVDvlgTAPDVH 191
Cdd:PRK06815 100 EQASAI-KLDAIRALGAEVRLYG---GDALNAelaARRAAEQqgKVYISPYN--DPQVIAGQGTIGMELVE---QQPDLD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 192 AL--PVGNAGNITaywkGYTEYhqLGLIDKLPRMLGTQAAGAA----PLVLGEPVSHPE--TIATAIRIG-SPASWTsaV 262
Cdd:PRK06815 171 AVfvAVGGGGLIS----GIATY--LKTLSPKTEIIGCWPANSPslytSLEAGEIVEVAEqpTLSDGTAGGvEPGAIT--F 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114793663 263 EAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDgwvARGSTVVCTVTG 327
Cdd:PRK06815 243 PLCQQLIDQKVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAALKLAPR---YQGKKVAVVLCG 304
|
|
| L-Ser-dehyd |
cd06448 |
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ... |
39-304 |
2.05e-18 |
|
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Pssm-ID: 107209 Cd Length: 316 Bit Score: 84.66 E-value: 2.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQ---RAVLCASTGNTSASAAAYAARAGITCAVLI 115
Cdd:cd06448 2 TPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGLnecVHVVCSSGGNAGLAAAYAARKLGVPCTIVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 116 PQ--GKIAMGKLAQAvmhGAKIIQIDGNFDDCLELARK--MAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTA--PD 189
Cdd:cd06448 82 PEstKPRVVEKLRDE---GATVVVHGKVWWEADNYLREelAENDPGPVYVHPFDDPLIWEGHSSMVDEIAQQLQSQekVD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 190 VHALPVGNAGNITAYWKGYTEYHQlgliDKLPrMLGTQAAGA----APLVLGEPVSHPETIATAIRIGSPASWTSAVEAQ 265
Cdd:cd06448 159 AIVCSVGGGGLLNGIVQGLERNGW----GDIP-VVAVETEGAhslnASLKAGKLVTLPKITSVATSLGAKTVSSQALEYA 233
|
250 260 270
....*....|....*....|....*....|....*....
gi 114793663 266 QQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIA 304
Cdd:cd06448 234 QEHNIKSEVVSDRDAVQACLRFADDERILVEPACGAALA 272
|
|
| eutB |
PRK07476 |
threonine dehydratase; Provisional |
39-335 |
1.20e-14 |
|
threonine dehydratase; Provisional
Pssm-ID: 236025 [Multi-domain] Cd Length: 322 Bit Score: 73.85 E-value: 1.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTdALAHGQRA--VLCASTGNTSASAAAYAARAGITCAV--- 113
Cdd:PRK07476 20 TPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNALL-SLSAQERArgVVTASTGNHGRALAYAARALGIRATIcms 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 114 -LIPQGKIAmgklaqAV-MHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLgtaPDVH 191
Cdd:PRK07476 99 rLVPANKVD------AIrALGAEVRIVGRSQDDAQAEVERLVREEGLTMVPPFDDPRIIAGQGTIGLEILEAL---PDVA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 192 ALPV-----GNAGNITAYWKGyteyhqlglIDKLPRMLGTQ----AAGAAPLVLGEPVSHPE--TIATAIR--IGSPASW 258
Cdd:PRK07476 170 TVLVplsggGLASGVAAAVKA---------IRPAIRVIGVSmergAAMHASLAAGRPVQVEEvpTLADSLGggIGLDNRY 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114793663 259 TSAVeAQQQSKGRFLaASDEEILAAYHLVARVEGVFVEPASAASIAGLLkaiDDGWVARGSTVVCTVTGNGLkDPDT 335
Cdd:PRK07476 241 TFAM-CRALLDDVVL-LDEAEIAAGIRHAYREERLVVEGAGAVGIAALL---AGKIAARDGPIVVVVSGANI-DMEL 311
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
37-323 |
2.94e-14 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 72.39 E-value: 2.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 37 GGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDR-GMTMaVTDALAHGQ----RAVLCASTGNTsasaaayaaraGI-- 109
Cdd:COG0031 12 GNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRiALSM-IEDAEKRGLlkpgGTIVEATSGNT-----------GIgl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 110 --TCAVL-------IPQgKIAMGKLAQAVMHGAKIIQIDG--NFDDCLELARKMAADFPtislvNSV------NPVRIEG 172
Cdd:COG0031 80 amVAAAKgyrlilvMPE-TMSKERRALLRAYGAEVVLTPGaeGMKGAIDKAEELAAETP-----GAFwpnqfeNPANPEA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 173 -QKTAAFEIVDVLGTAPDVHALPVGNAGNITaywkGYTEYhqlgLIDKLP--RMLGTQAAGAAPLVLGEPVSHPetiata 249
Cdd:COG0031 154 hYETTGPEIWEQTDGKVDAFVAGVGTGGTIT----GVGRY----LKERNPdiKIVAVEPEGSPLLSGGEPGPHK------ 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114793663 250 IR-IGS---PASW-TSAVEaqqqskgRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDgwVARGSTVVC 323
Cdd:COG0031 220 IEgIGAgfvPKILdPSLID-------EVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR--LGPGKTIVT 289
|
|
| PRK08638 |
PRK08638 |
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB; |
39-327 |
1.90e-13 |
|
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
Pssm-ID: 236317 [Multi-domain] Cd Length: 333 Bit Score: 70.53 E-value: 1.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGM---TMAVTDalAHGQRAVLCASTGNTSASAAAYAARAGITCAVLI 115
Cdd:PRK08638 28 TPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAfnkLSSLTD--AEKRKGVVACSAGNHAQGVALSCALLGIDGKVVM 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 116 PQGKIAMgKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVhALPV 195
Cdd:PRK08638 106 PKGAPKS-KVAATCGYGAEVVLHGDNFNDTIAKVEEIVEEEGRTFIPPYDDPKVIAGQGTIGLEILEDLWDVDTV-IVPI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 196 GNAGNITAYWKGyteyhqLGLIDKLPRMLGTQAAG----AAPLVLGEPVSHPE--TIATAIRIGSPASWTsaVEAQQQSK 269
Cdd:PRK08638 184 GGGGLIAGIAVA------LKSINPTIHIIGVQSENvhgmAASFYAGEITTHRTtgTLADGCDVSRPGNLT--YEIVRELV 255
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 114793663 270 GRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVaRGSTVVCTVTG 327
Cdd:PRK08638 256 DDIVLVSEDEIRNAMKDLIQRNKVVTEGAGALATAALLSGKLDQYI-QNKKVVAIISG 312
|
|
| PRK07334 |
PRK07334 |
threonine dehydratase; Provisional |
39-308 |
2.16e-11 |
|
threonine dehydratase; Provisional
Pssm-ID: 235994 [Multi-domain] Cd Length: 403 Bit Score: 64.53 E-value: 2.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMT---MAVTDalAHGQRAVLCASTGNTSASAAAYAARAGITCAVLI 115
Cdd:PRK07334 24 TPCVHSRTLSQITGAEVWLKFENLQFTASFKERGALnklLLLTE--EERARGVIAMSAGNHAQGVAYHAQRLGIPATIVM 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 116 PQGKiAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADfPTISLVNSVN-PVRIEGQKTAAFEIvdvLGTAPDVHAL- 193
Cdd:PRK07334 102 PRFT-PTVKVERTRGFGAEVVLHGETLDEARAHARELAEE-EGLTFVHPYDdPAVIAGQGTVALEM---LEDAPDLDTLv 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 194 -PVGNAGNI----TAYwKGyteyhqlglIDKLPRMLGTQAAG-----AAPLVLGEPVSHpETIATAIRIGSPASWTSAVE 263
Cdd:PRK07334 177 vPIGGGGLIsgmaTAA-KA---------LKPDIEIIGVQTELypsmyAAIKGVALPCGG-STIAEGIAVKQPGQLTLEIV 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 114793663 264 AQQQSkgRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLK 308
Cdd:PRK07334 246 RRLVD--DILLVSEADIEQAVSLLLEIEKTVVEGAGAAGLAALLA 288
|
|
| PRK12483 |
PRK12483 |
threonine dehydratase; Reviewed |
39-206 |
5.28e-11 |
|
threonine dehydratase; Reviewed
Pssm-ID: 237111 [Multi-domain] Cd Length: 521 Bit Score: 63.66 E-value: 5.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRG----MTMAVTDALAhgqRAVLCASTGNTSASAAAYAARAGITCAVL 114
Cdd:PRK12483 38 TPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGaynkMARLPAEQLA---RGVITASAGNHAQGVALAAARLGVKAVIV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 115 IPQGKIAMgKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALP 194
Cdd:PRK12483 115 MPRTTPQL-KVDGVRAHGGEVVLHGESFPDALAHALKLAEEEGLTFVPPFDDPDVIAGQGTVAMEILRQHPGPLDAIFVP 193
|
170
....*....|....*
gi 114793663 195 VGNAG---NITAYWK 206
Cdd:PRK12483 194 VGGGGliaGIAAYVK 208
|
|
| PRK08813 |
PRK08813 |
threonine dehydratase; Provisional |
57-199 |
1.06e-10 |
|
threonine dehydratase; Provisional
Pssm-ID: 236339 [Multi-domain] Cd Length: 349 Bit Score: 62.34 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 57 LKVEGLNPTGSFKDRGMTMAVTDALAHG-QRAVLCASTGNTSASAAAYAARAGITCAVLIPQGKIAMgKLAQAVMHGAKI 135
Cdd:PRK08813 52 LKLENLQRTGSYKVRGALNALLAGLERGdERPVICASAGNHAQGVAWSAYRLGVQAITVMPHGAPQT-KIAGVAHWGATV 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 114793663 136 IQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVdvlGTAPDVHALPVGNAG 199
Cdd:PRK08813 131 RQHGNSYDEAYAFARELADQNGYRFLSAFDDPDVIAGQGTVGIELA---AHAPDVVIVPIGGGG 191
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
37-116 |
4.48e-09 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 57.69 E-value: 4.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 37 GGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRA----VLCASTGNTSASAAAYAARAGITCA 112
Cdd:PLN02356 52 GNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFpggvVTEGSAGSTAISLATVAPAYGCKCH 131
|
....
gi 114793663 113 VLIP 116
Cdd:PLN02356 132 VVIP 135
|
|
| Thr-synth_2 |
cd01560 |
Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of ... |
64-203 |
4.52e-09 |
|
Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, archaebacteria and eubacterial groups. This CD, Thr-synth_2, includes enzymes from fungi and eubacterial groups, as well as, metazoan threonine synthase-like proteins.
Pssm-ID: 107203 [Multi-domain] Cd Length: 460 Bit Score: 57.63 E-value: 4.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 64 PTGSFKDRGM--TMAVTDALAHGQR---AVLCASTGNT-SASAAAYAARAGITCAVLIPQGKIAmgKLAQAVMHGA---- 133
Cdd:cd01560 106 PTLAFKDMALqfLGRLLEYFLKRRNeriTILVATSGDTgSAAIEGFRGKPNVDVVVLYPKGGVS--PIQELQMTTLpadn 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 134 -KIIQIDGNFDDCLELARKMAADFP-----TISLVNSVNPVRIEGQKT----AAFEiVDVLGTAPDVH-ALPVGNAGNIT 202
Cdd:cd01560 184 vHVVAVEGDFDDCQSLVKALFADEDfnkklKLSSANSINWARILAQIVyyfyAYLQ-LLKRGEGEKVEfSVPTGNFGNIL 262
|
.
gi 114793663 203 A 203
Cdd:cd01560 263 A 263
|
|
| PRK09224 |
PRK09224 |
threonine ammonia-lyase IlvA; |
39-308 |
5.13e-09 |
|
threonine ammonia-lyase IlvA;
Pssm-ID: 236417 [Multi-domain] Cd Length: 504 Bit Score: 57.46 E-value: 5.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRG----MTMAVTDALAHGqraVLCASTGNTSASAAAYAARAGITcAVL 114
Cdd:PRK09224 21 TPLEKAPKLSARLGNQVLLKREDLQPVFSFKLRGaynkMAQLTEEQLARG---VITASAGNHAQGVALSAARLGIK-AVI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 115 I-----PQGKI----AMGklAQAVMHGAkiiqidgNFDDCLELARKMAA----------DFPTIslvnsvnpvrIEGQKT 175
Cdd:PRK09224 97 VmpvttPDIKVdavrAFG--GEVVLHGD-------SFDEAYAHAIELAEeegltfihpfDDPDV----------IAGQGT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 176 AAFEIVDVLGTAPDVHALPVGNAG---NITAYWKgyteyhQLglidkLP--RMLGTQAAGAAPLVL----GEPVSHPET- 245
Cdd:PRK09224 158 IAMEILQQHPHPLDAVFVPVGGGGliaGVAAYIK------QL-----RPeiKVIGVEPEDSACLKAaleaGERVDLPQVg 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 114793663 246 -----IATAiRIGspaswTSAVEAQQQSKGRFLAASDEEILAAyhlvarVEGVF------VEPASAASIAGLLK 308
Cdd:PRK09224 227 lfadgVAVK-RIG-----EETFRLCQEYVDDVITVDTDEICAA------IKDVFedtrsiAEPAGALALAGLKK 288
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
57-307 |
5.26e-09 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 56.89 E-value: 5.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 57 LKVEGLNPTGSFKDRGmtmAVTDALAHGQRA--VLCASTGNTSASAAAYAARAGITCAVLIP----QGKIAmgKLAQavm 130
Cdd:PRK08246 41 LKLEHLQHTGSFKARG---AFNRLLAAPVPAagVVAASGGNAGLAVAYAAAALGVPATVFVPetapPAKVA--RLRA--- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 131 HGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGtAPDVHALPVGNAG---NITAYWKG 207
Cdd:PRK08246 113 LGAEVVVVGAEYADALEAAQAFAAETGALLCHAYDQPEVLAGAGTLGLEIEEQAP-GVDTVLVAVGGGGliaGIAAWFEG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 208 YTeyhqlglidklpRMLGTQAAGA----APLVLGEPVSHP-ETIAT----AIRIGSPAsWTSAVEAQQQSkgrfLAASDE 278
Cdd:PRK08246 192 RA------------RVVAVEPEGAptlhAALAAGEPVDVPvSGIAAdslgARRVGEIA-FALARAHVVTS----VLVSDE 254
|
250 260
....*....|....*....|....*....
gi 114793663 279 EILAAYHLVARVEGVFVEPASAASIAGLL 307
Cdd:PRK08246 255 AIIAARRALWEELRLAVEPGAATALAALL 283
|
|
| PRK06608 |
PRK06608 |
serine/threonine dehydratase; |
39-199 |
4.95e-08 |
|
serine/threonine dehydratase;
Pssm-ID: 235842 [Multi-domain] Cd Length: 338 Bit Score: 54.01 E-value: 4.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRA--VLCASTGNTSASAAAYAARAGITCAVLIP 116
Cdd:PRK06608 24 TPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGVLNHLLELKEQGKLPdkIVAYSTGNHGQAVAYASKLFGIKTRIYLP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 117 QgKIAMGKLAQAVMHGAKIIQIdgNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVG 196
Cdd:PRK06608 104 L-NTSKVKQQAALYYGGEVILT--NTRQEAEEKAKEDEEQGFYYIHPSDSDSTIAGAGTLCYEALQQLGFSPDAIFASCG 180
|
...
gi 114793663 197 NAG 199
Cdd:PRK06608 181 GGG 183
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
32-140 |
1.35e-07 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 52.56 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 32 VTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQ----RAVLCASTGNTSASAAAYAARA 107
Cdd:PRK10717 7 VSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLlkpgGTIVEGTAGNTGIGLALVAAAR 86
|
90 100 110
....*....|....*....|....*....|....*..
gi 114793663 108 GITCAVLIP----QGKIAMGKLaqavmHGAKIIQIDG 140
Cdd:PRK10717 87 GYKTVIVMPetqsQEKKDLLRA-----LGAELVLVPA 118
|
|
| PLN02550 |
PLN02550 |
threonine dehydratase |
39-206 |
2.26e-07 |
|
threonine dehydratase
Pssm-ID: 178165 [Multi-domain] Cd Length: 591 Bit Score: 52.62 E-value: 2.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGM-TMAVTDALAHGQRAVLCASTGNTSASAAAYAARAGITCAVLIPq 117
Cdd:PLN02550 110 SPLQLAKKLSERLGVKVLLKREDLQPVFSFKLRGAyNMMAKLPKEQLDKGVICSSAGNHAQGVALSAQRLGCDAVIAMP- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 118 gkIAMGKLA-QAVMH-GAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLgTAPdVHAL-- 193
Cdd:PLN02550 189 --VTTPEIKwQSVERlGATVVLVGDSYDEAQAYAKQRALEEGRTFIPPFDHPDVIAGQGTVGMEIVRQH-QGP-LHAIfv 264
|
170
....*....|....*.
gi 114793663 194 PVGNAG---NITAYWK 206
Cdd:PLN02550 265 PVGGGGliaGIAAYVK 280
|
|
| PRK06110 |
PRK06110 |
threonine dehydratase; |
39-308 |
8.22e-07 |
|
threonine dehydratase;
Pssm-ID: 235699 Cd Length: 322 Bit Score: 49.99 E-value: 8.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGmTMAVTDALAHGQ---RAVLCASTGNTSASAAAYAARAGITCAVLI 115
Cdd:PRK06110 22 TPQYRWPLLAERLGCEVWVKHENHTPTGAFKVRG-GLVYFDRLARRGprvRGVISATRGNHGQSVAFAARRHGLAATIVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 116 PQG-----KIAMGKLaqavmhGAKIIQIDGNFDDCLELARKMAAdFPTISLVNSVNPVRIEGQKTAAFEIvdvLGTAPDV 190
Cdd:PRK06110 101 PHGnsvekNAAMRAL------GAELIEHGEDFQAAREEAARLAA-ERGLHMVPSFHPDLVRGVATYALEL---FRAVPDL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 191 HAL--PVGNAGNItaywkgyteyhqLGLI---DKL---PRMLGTQAAGAAPLVL----GEPVSHP--ETIA--TAIRIGS 254
Cdd:PRK06110 171 DVVyvPIGMGSGI------------CGAIaarDALglkTRIVGVVSAHAPAYALsfeaGRVVTTPvaTTLAdgMACRTPD 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 114793663 255 PaswtSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLK 308
Cdd:PRK06110 239 P----EALEVIRAGADRIVRVTDDEVAAAMRAYFTDTHNVAEGAGAAALAAALQ 288
|
|
| PRK13803 |
PRK13803 |
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional |
39-340 |
1.30e-06 |
|
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
Pssm-ID: 237513 [Multi-domain] Cd Length: 610 Bit Score: 50.19 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKdrgmtmaVTDALahGQrAVLCASTGNTSASAAAYAARAGI----TCAVL 114
Cdd:PRK13803 272 TPLTEAKRLSDIYGARIYLKREDLNHTGSHK-------INNAL--GQ-ALLAKRMGKTRIIAETGAGQHGVatatACALF 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 115 IPQGKIAMGKL-----AQAV----MHGAKIIQIDG------------------NFDDCLELARKMAADFPTISLVNSVNP 167
Cdd:PRK13803 342 GLKCTIFMGEEdikrqALNVermkLLGANVIPVLSgsktlkdavneairdwvaSVPDTHYLIGSAVGPHPYPEMVAYFQS 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 168 VRIEGQKTaafEIVDVLGTAPDVHALPVGNAGNITAYWKGYteyhqlgLIDKLPRMLGTQAAGaaplvLGepVSHPETIA 247
Cdd:PRK13803 422 VIGEEAKE---QLKEQTGKLPDAIIACVGGGSNAIGIFYHF-------LDDPSVKLIGVEAGG-----KG--VNTGEHAA 484
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 248 TaIRIGSPA----SWT----------------SA---------VEAQQQSKGR--FLAASDEEILAAYHLVARVEGVFVE 296
Cdd:PRK13803 485 T-IKKGRKGvlhgSMTylmqdengqilephsiSAgldypgigpMHANLFETGRaiYTSVTDEEALDAFKLLAKLEGIIPA 563
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 114793663 297 PASAASIAGLLKAidDGWVARGSTVVCTVTGNGLKDPDTALKDM 340
Cdd:PRK13803 564 LESSHALAYLKEG--RKKFKKKDIVIVNLSGRGDKDIPTLKEYF 605
|
|
| PRK07048 |
PRK07048 |
threo-3-hydroxy-L-aspartate ammonia-lyase; |
39-327 |
2.43e-06 |
|
threo-3-hydroxy-L-aspartate ammonia-lyase;
Pssm-ID: 235918 [Multi-domain] Cd Length: 321 Bit Score: 48.86 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRA-VLCASTGNTSASAAAYAARAGITCAVLIPQ 117
Cdd:PRK07048 25 TPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGAYNALSQFSPEQRRAgVVTFSSGNHAQAIALSARLLGIPATIVMPQ 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 118 GKIAMgKLAQAVMHGAKIIQIDGNFDDCLELARKMAADfPTISLVNSVN-PVRIEGQKTAAFEIVDVLGtAPDVHALPVG 196
Cdd:PRK07048 105 DAPAA-KVAATRGYGGEVVTYDRYTEDREEIGRRLAEE-RGLTLIPPYDhPHVIAGQGTAAKELFEEVG-PLDALFVCLG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 197 NAGNI--TAywkgyteyhqlglidklprmLGTQAAGAAPLVLG-EP-----------------VSHPETIATAIRIGSPA 256
Cdd:PRK07048 182 GGGLLsgCA--------------------LAARALSPGCKVYGvEPeagndgqqsfrsgeivhIDTPRTIADGAQTQHLG 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114793663 257 SWTSAVeaQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDgwvARGSTVVCTVTG 327
Cdd:PRK07048 242 NYTFPI--IRRLVDDIVTVSDAELVDAMRFFAERMKIVVEPTGCLGAAAALRGKVP---LKGKRVGVIISG 307
|
|
| cysKM |
TIGR01136 |
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ... |
32-308 |
2.97e-06 |
|
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273463 Cd Length: 299 Bit Score: 48.43 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 32 VTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDR-GMTMaVTDALAHGQ----RAVLCASTGNTSASAAAYAAR 106
Cdd:TIGR01136 1 IEELIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRiALSM-ILDAEKRGLlkpgDTIIEATSGNTGIALAMVAAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 107 AGITCAVLIPQgkiAMGKLAQAVM--HGAKIIQIDGN--FDDCLELARKMAADFPTISLVNSV-NPVRIEG-QKTAAFEI 180
Cdd:TIGR01136 80 RGYKLILTMPE---TMSLERRKLLraYGAELILTPGEegMKGAIDKAEELAAETNKYVMLDQFeNPANPEAhYKTTGPEI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 181 VDVLGTAPDVHALPVGNAGNITaywkGYTEYhqlgLIDKLP--RMLGTQAAGAAPLVLGEPVSHPetiataIRiGSPASW 258
Cdd:TIGR01136 157 WRDTDGRIDHFVAGVGTGGTIT----GVGRY----LKEQNPniQIVAVEPAESPVLSGGEPGPHK------IQ-GIGAGF 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 114793663 259 TSAVEAQQQSKGRFLAASDEEILAAYHLvARVEGVFVEPASAASIAGLLK 308
Cdd:TIGR01136 222 IPKILDLSLIDEVITVSDEDAIETARRL-AREEGILVGISSGAAVAAALK 270
|
|
| PLN02970 |
PLN02970 |
serine racemase |
39-307 |
2.23e-05 |
|
serine racemase
Pssm-ID: 215524 [Multi-domain] Cd Length: 328 Bit Score: 45.82 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALA-HGQRAVLCASTGNTSASAAAYAARAGITCAVLIPQ 117
Cdd:PLN02970 28 TPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDdQAEKGVVTHSSGNHAAALALAAKLRGIPAYIVVPK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 118 GKiAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADfPTISLVNSVNPVR-IEGQKTAAFEIVDvlgTAPDVHAL--P 194
Cdd:PLN02970 108 NA-PACKVDAVIRYGGIITWCEPTVESREAVAARVQQE-TGAVLIHPYNDGRvISGQGTIALEFLE---QVPELDVIivP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 195 VGNAGNIT---AYWKGyteyhqlglIDKLPRMLGTQAAG----AAPLVLGEPVS--HPETIATAIRiGSPASWTSAVEAQ 265
Cdd:PLN02970 183 ISGGGLISgiaLAAKA---------IKPSIKIIAAEPKGaddaAQSKAAGEIITlpVTNTIADGLR-ASLGDLTWPVVRD 252
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 114793663 266 QQSKgrFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLL 307
Cdd:PLN02970 253 LVDD--VITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAAL 292
|
|
| Trp-synth_B |
cd06446 |
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the ... |
39-335 |
2.69e-05 |
|
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to glyceraldehyde 3-phosphate and indole at the active site of the alpha subunit. In the beta reaction, indole undergoes a PLP-dependent reaction with L-serine to form L-tryptophan at the active site of the beta subunit. Members of this CD, Trp-synth_B, are found in all three major phylogenetic divisions.
Pssm-ID: 107207 Cd Length: 365 Bit Score: 45.60 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQT-GCTIHLKVEGLNPTGSFKdrgmtmaVTDALAH------------------GQRAVLCAstgntsas 99
Cdd:cd06446 35 TPLYRAKRLSEYLgGAKIYLKREDLNHTGAHK-------INNALGQallakrmgkkrviaetgaGQHGVATA-------- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 100 aaayaaragITCAVLIPQGKIAMGKL---AQAV------MHGAKIIQIDGNF-------DDCLELARKMAADfpTISLVN 163
Cdd:cd06446 100 ---------TACALFGLECEIYMGAVdveRQPLnvfrmeLLGAEVVPVPSGSgtlkdaiSEAIRDWVTNVED--THYLLG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 164 SV-------NPVR----IEGQKTAAfEIVDVLGTAPDVHALPVG---NAGNITaywkgyteYHQLGliDKLPRMLGTQAA 229
Cdd:cd06446 169 SVvgphpypNMVRdfqsVIGEEAKK-QILEKEGELPDVVIACVGggsNAAGLF--------YPFIN--DKDVKLIGVEAG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 230 G--------AAPLVLGEP-VSH----------------PETIATAIR---IGSPASWTsaveaqqQSKGR--FLAASDEE 279
Cdd:cd06446 238 GcgletgghAAYLFGGTAgVLHglkmytlqdedgqivpPHSISAGLDypgVGPEHAYL-------KDSGRveYVAVTDEE 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 114793663 280 ILAAYHLVARVEGVFVEPASAASIAGLLK-AIDDGwvaRGSTVVCTVTGNGLKDPDT 335
Cdd:cd06446 311 ALEAFKLLARTEGIIPALESSHAIAYAIKlAKKLG---KEKVIVVNLSGRGDKDLQT 364
|
|
| cysM |
PRK11761 |
cysteine synthase CysM; |
37-96 |
6.83e-05 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 44.09 E-value: 6.83e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 114793663 37 GGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRA---VLC-ASTGNT 96
Cdd:PRK11761 11 GNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKpgdTLIeATSGNT 74
|
|
| PLN03013 |
PLN03013 |
cysteine synthase |
21-308 |
1.14e-04 |
|
cysteine synthase
Pssm-ID: 178587 [Multi-domain] Cd Length: 429 Bit Score: 44.00 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 21 DRLPVGDDwtpVTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDA-----LAHGQRAVLCASTGN 95
Cdd:PLN03013 109 DGLNIADN---VSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAeqkgfISPGKSVLVEPTSGN 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 96 TSASAAAYAARAGITCAVLIPqGKIAMGKLAQAVMHGAKIIQID------GNFDDCLELARKMAADFPTISLVNSVNPvR 169
Cdd:PLN03013 186 TGIGLAFIAASRGYRLILTMP-ASMSMERRVLLKAFGAELVLTDpakgmtGAVQKAEEILKNTPDAYMLQQFDNPANP-K 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 170 IEGQKTAAfEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEyhqlglidKLPRmlgTQAAGAAP-----LVLGEPVSHpe 244
Cdd:PLN03013 264 IHYETTGP-EIWDDTKGKVDIFVAGIGTGGTITGVGRFIKE--------KNPK---TQVIGVEPtesdiLSGGKPGPH-- 329
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 114793663 245 tiataiRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLK 308
Cdd:PLN03013 330 ------KIQGIGAGFIPKNLDQKIMDEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIK 387
|
|
| PRK04346 |
PRK04346 |
tryptophan synthase subunit beta; Validated |
271-338 |
1.27e-04 |
|
tryptophan synthase subunit beta; Validated
Pssm-ID: 235288 Cd Length: 397 Bit Score: 43.52 E-value: 1.27e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 271 RFLAASDEEILAAYHLVARVEGVFvePA--SAASIAGLLKAIDDgwVARGSTVVCTVTGNGLKDPDTALK 338
Cdd:PRK04346 326 EYVSITDDEALEAFQLLSRLEGII--PAleSSHALAYALKLAPT--LGKDQIIVVNLSGRGDKDVFTVAK 391
|
|
| PLN00011 |
PLN00011 |
cysteine synthase |
21-308 |
2.50e-04 |
|
cysteine synthase
Pssm-ID: 177651 Cd Length: 323 Bit Score: 42.30 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 21 DRLPVGDDwtpVTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDA-----LAHGQRAVLCASTGN 95
Cdd:PLN00011 3 DRCLIKND---VTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAedkglITPGKSTLIEATAGN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 96 TSASAAAYAARAGITCAVLIP-----QGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPvRI 170
Cdd:PLN00011 80 TGIGLACIGAARGYKVILVMPstmslERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANP-EI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 171 EGQKTAAFEIVDVLGTApDVHALPVGNAGNITAYWKGYTEYhqlgliDKLPRMLGTQAAGAAPLVLGEPVSH-PETIATA 249
Cdd:PLN00011 159 HYRTTGPEIWRDSAGKV-DILVAGVGTGGTATGVGKFLKEK------NKDIKVCVVEPVESAVLSGGQPGPHlIQGIGSG 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 114793663 250 IrIGSPASWTSAVEAQQqskgrflaASDEEILAAYHLVARVEGVFVEPASAASIAGLLK 308
Cdd:PLN00011 232 I-IPFNLDLTIVDEIIQ--------VTGEEAIETAKLLALKEGLLVGISSGAAAAAALK 281
|
|
| PLN02618 |
PLN02618 |
tryptophan synthase, beta chain |
185-338 |
5.43e-04 |
|
tryptophan synthase, beta chain
Pssm-ID: 215333 Cd Length: 410 Bit Score: 41.66 E-value: 5.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 185 GTAPDVHALPVGNAGNITAYWKGYTEyhqlgliDKLPRMLGTQAAG--------AAPLVLGEP-VSH------------- 242
Cdd:PLN02618 237 GGKPDVLVACVGGGSNAMGLFHEFID-------DEDVRLIGVEAAGfgldsgkhAATLTKGEVgVLHgamsyllqdedgq 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 243 ---PETIATAIR---IGSPASWTSAVEaqqqsKGRFLAASDEEILAAYHLVARVEGVFvePASAAS--IAGLLKAIDDgw 314
Cdd:PLN02618 310 iiePHSISAGLDypgVGPEHSFLKDTG-----RAEYYSVTDEEALEAFQRLSRLEGII--PALETShaLAYLEKLCPT-- 380
|
170 180
....*....|....*....|....
gi 114793663 315 VARGSTVVCTVTGNGLKDPDTALK 338
Cdd:PLN02618 381 LPDGTKVVVNCSGRGDKDVNTAIK 404
|
|
| PRK08206 |
PRK08206 |
diaminopropionate ammonia-lyase; Provisional |
39-154 |
1.93e-03 |
|
diaminopropionate ammonia-lyase; Provisional
Pssm-ID: 236186 Cd Length: 399 Bit Score: 39.86 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114793663 39 TPLIAATNLSKQTGC-TIHLKVE----GLNptgSFKDRGMTMAVT----------------DALAHGQ-RAVL------C 90
Cdd:PRK08206 45 TPLVALPDLAAELGVgSILVKDEsyrfGLN---AFKALGGAYAVArllaeklgldiselsfEELTSGEvREKLgditfaT 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 114793663 91 ASTGNTSASAAAYAARAGITCAVLIPQGkIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAA 154
Cdd:PRK08206 122 ATDGNHGRGVAWAAQQLGQKAVIYMPKG-SSEERVDAIRALGAECIITDGNYDDSVRLAAQEAQ 184
|
|
| PRK12391 |
PRK12391 |
TrpB-like pyridoxal phosphate-dependent enzyme; |
39-69 |
4.67e-03 |
|
TrpB-like pyridoxal phosphate-dependent enzyme;
Pssm-ID: 237087 Cd Length: 427 Bit Score: 38.62 E-value: 4.67e-03
10 20 30
....*....|....*....|....*....|...
gi 114793663 39 TPLIAATNLSK--QTGCTIHLKVEGLNPTGSFK 69
Cdd:PRK12391 78 TPLIRARRLEKalGTPAKIYYKYEGVSPTGSHK 110
|
|
| |
