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Conserved domains on  [gi|1147813|gb|AAA85135|]
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desmoplakin I [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 548-625 5.16e-35

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


:

Pssm-ID: 465730  Cd Length: 78  Bit Score: 129.26  E-value: 5.16e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813     548 VSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQ 625
Cdd:pfam18373    1 VSWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1014-1881 2.75e-31

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 135.18  E-value: 2.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1014 YRFLSEMLKSLEdLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSA 1093
Cdd:TIGR02168  215 YKELKAELRELE-LALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYAL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1094 KQNLDKCYGQIKELNEK-------ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKarqcekenlgwqKLESEKAike 1166
Cdd:TIGR02168  294 ANEISRLEQQKQILRERlanlerqLEELEAQLEELESKLDELAEELAELEEKLEELKE------------ELESLEA--- 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1167 keyEIERLRVLLQEEGTRKREYENELAKVRNHYNEeMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSR-E 1245
Cdd:TIGR02168  359 ---ELEELEAELEELESRLEELEEQLETLRSKVAQ-LELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaE 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1246 NRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS--EDNARHKQSLEEAAKTIQDK 1323
Cdd:TIGR02168  435 LKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDslERLQENLEGFSEGVKALLKN 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1324 NKEIERLKAEFQEEAKRRWEYENELSKV----RNNY---DEEIISLKNQFETEINITKTTIHQLTMQKEedtsgyrAQID 1396
Cdd:TIGR02168  515 QSGLSGILGVLSELISVDEGYEAAIEAAlggrLQAVvveNLNAAKKAIAFLKQNELGRVTFLPLDSIKG-------TEIQ 587

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1397 NLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA---TGSEVSQRKQQLEVELRQVT---QMRTEESVRYKQSlD 1470
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLvvdDLDNALELAKKLRPGYRIVTldgDLVRPGGVITGGS-A 666

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1471 DAAKTIQDKNKEIERLKQLIDKetndrkcLEDENARLQRVQYDLQKANSSATETINKLKVQEQEltrlridyervsqert 1550
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEE-------LEEKIAELEKALAELRKELEELEEELEQLRKELEE---------------- 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1551 vKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQAsivkkrsE 1630
Cdd:TIGR02168  724 -LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL-------K 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1631 DDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLT 1710
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESEL 875

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1711 ENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNatilELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQKQ 1790
Cdd:TIGR02168  876 EALLNERASLEEALALLRSELEELSEELRELESKRS----ELRRELE-------ELREKLAQLELRLEGLEVRIDNLQER 944

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1791 ALEASNRIQEsknqctqVVQERESLLV-KIKVLEQDKARLQRLEDELNRAKSTLEAETR-VKQRLECEKQQIqNDLNQWK 1868
Cdd:TIGR02168  945 LSEEYSLTLE-------EAEALENKIEdDEEEARRRLKRLENKIKELGPVNLAAIEEYEeLKERYDFLTAQK-EDLTEAK 1016

                          890
                   ....*....|...
gi 1147813    1869 TQYsrkEEAIRKI 1881
Cdd:TIGR02168 1017 ETL---EEAIEEI 1026
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 447-513 2.28e-26

SH3 domain; This entry represents an SH3 domain.


:

Pssm-ID: 407754  Cd Length: 65  Bit Score: 103.88  E-value: 2.28e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813     447 QLKPRNpdYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIP 513
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2291-2329 1.33e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 69.66  E-value: 1.33e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2291 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKL 2329
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2367-2405 2.31e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 68.89  E-value: 2.31e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2367 LLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEIL 2405
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2650-2686 1.03e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 66.97  E-value: 1.03e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1147813    2650 LLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMAT 2686
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQ 37
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2124-2162 1.66e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 63.89  E-value: 1.66e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2124 LLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSL 2162
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2048-2086 3.46e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 62.73  E-value: 3.46e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2048 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQI 2086
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 285-450 6.19e-11

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


:

Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 64.77  E-value: 6.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:cd00176   15 WLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELREL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   365 TKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKErekILEYKRQVQNLVNKSKK 444
Cdd:cd00176   95 AEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEE---LEAHEPRLKSLNELAEE 171


                 ....*.
gi 1147813   445 IVQLKP 450
Cdd:cd00176  172 LLEEGH 177
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2726-2764 6.84e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 56.18  E-value: 6.84e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2726 FLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRL 2764
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
2084-2121 3.42e-07

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.63  E-value: 3.42e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETG 2121
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2468-2496 3.52e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 48.48  E-value: 3.52e-07
                           10        20
                   ....*....|....*....|....*....
gi 1147813    2468 IVDPETNKEMSVQEAYKKGLIDYETFKEL 2496
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC super family cl02488
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 190-366 1.23e-06

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


The actual alignment was detected with superfamily member cd00176:

Pssm-ID: 413338 [Multi-domain]  Cd Length: 213  Bit Score: 52.06  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   190 ECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA---DLREKSAIY---------QLEEEYEN 257
Cdd:cd00176   11 ELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNElgeQLIEEGHPDaeeiqerleELNQRWEE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   258 LLKASFERMDHL---RQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESD 334
Cdd:cd00176   91 LRELAEERRQRLeeaLDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSLNELAE 170

                        170       180       190
                 ....*....|....*....|....*....|...
gi 1147813   335 QLVLNQHPAS-DKIEAYMDTLQTQWSWILQITK 366
Cdd:cd00176  171 ELLEEGHPDAdEEIEEKLEELNERWEELLELAE 203
PLEC smart00250
Plectin repeat;
2251-2288 2.48e-06

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.32  E-value: 2.48e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2251 KDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTA 2288
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2328-2364 1.80e-05

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.62  E-value: 1.80e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1147813     2328 KLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 2364
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2611-2647 1.00e-04

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.70  E-value: 1.00e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1147813     2611 DTLEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2647
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2762-2799 4.77e-03

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.08  E-value: 4.77e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2762 QRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG 2799
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PRK01156 super family cl30905
chromosome segregation protein; Provisional
 707-1281 8.02e-03

chromosome segregation protein; Provisional


The actual alignment was detected with superfamily member PRK01156:

Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.81  E-value: 8.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    707 NELKSVQNDSQAIAEVLNQLKDMLANF-----RGSEKYCYLQNEVFGLFQKLENINGVTDgYLNSLCTVRALLQAILQTE 781
Cdd:PRK01156  190 EKLKSSNLELENIKKQIADDEKSHSITlkeieRLSIEYNNAMDDYNNLKSALNELSSLED-MKNRYESEIKTAESDLSME 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    782 DMLKVYEARLtEEETVCLDLDKVEAYR---CGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSqqyplydlDLGKfge 858
Cdd:PRK01156  269 LEKNNYYKEL-EERHMKIINDPVYKNRnyiNDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLS--------VLQK--- 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    859 kvtqltDRWQRIDKQIdfRLWDLEKQIKQLRNYRDNYQAFCKWLYDRKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
Cdd:PRK01156  337 ------DYNDYIKKKS--RYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIK 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    939 GKRdksEEVQKiaelcanSIKDYELQLASYTSGLETLLN--IPIKRTM-IQSPSGVILQEAADVHARYIELLTRsgDYYr 1015
Cdd:PRK01156  409 KEL---NEINV-------KLQDISSKVSSLNQRIRALREnlDELSRNMeMLNGQSVCPVCGTTLGEEKSNHIIN--HYN- 475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1016 flsemlkslEDLKLKNTKIEVLEEElrlARDANSENCNKNKFLD----QNLQKYQAECSQFKAKLASLEELK-RQAELDG 1090
Cdd:PRK01156  476 ---------EKKSRLEEKIREIEIE---VKDIDEKIVDLKKRKEylesEEINKSINEYNKIESARADLEDIKiKINELKD 543

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1091 KSAKQNldkcygqikELNEKITRLTYEIEDEKR----RRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES------ 1160
Cdd:PRK01156  544 KHDKYE---------EIKNRYKSLKLEDLDSKRtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIgfpddk 614

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1161 ---EKAIKEKEYEIERLRVLLQEEGTRKREYEnELAKVRNHYNEEMSNLRnkyetEINITKTTIKEISMQKEDDSKNLRN 1237
Cdd:PRK01156  615 syiDKSIREIENEANNLNNKYNEIQENKILIE-KLRGKIDNYKKQIAEID-----SIIPDLKEITSRINDIEDNLKKSRK 688

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1147813   1238 QLD-------RLSRENRDLKDEIVRLNDSIlqaTEQRRRAEENALQQKACG 1281
Cdd:PRK01156  689 ALDdakanraRLESTIEILRTRINELSDRI---NDINETLESMKKIKKAIG 736
 
Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 548-625 5.16e-35

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 465730  Cd Length: 78  Bit Score: 129.26  E-value: 5.16e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813     548 VSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQ 625
Cdd:pfam18373    1 VSWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1014-1881 2.75e-31

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 135.18  E-value: 2.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1014 YRFLSEMLKSLEdLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSA 1093
Cdd:TIGR02168  215 YKELKAELRELE-LALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYAL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1094 KQNLDKCYGQIKELNEK-------ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKarqcekenlgwqKLESEKAike 1166
Cdd:TIGR02168  294 ANEISRLEQQKQILRERlanlerqLEELEAQLEELESKLDELAEELAELEEKLEELKE------------ELESLEA--- 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1167 keyEIERLRVLLQEEGTRKREYENELAKVRNHYNEeMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSR-E 1245
Cdd:TIGR02168  359 ---ELEELEAELEELESRLEELEEQLETLRSKVAQ-LELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaE 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1246 NRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS--EDNARHKQSLEEAAKTIQDK 1323
Cdd:TIGR02168  435 LKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDslERLQENLEGFSEGVKALLKN 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1324 NKEIERLKAEFQEEAKRRWEYENELSKV----RNNY---DEEIISLKNQFETEINITKTTIHQLTMQKEedtsgyrAQID 1396
Cdd:TIGR02168  515 QSGLSGILGVLSELISVDEGYEAAIEAAlggrLQAVvveNLNAAKKAIAFLKQNELGRVTFLPLDSIKG-------TEIQ 587

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1397 NLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA---TGSEVSQRKQQLEVELRQVT---QMRTEESVRYKQSlD 1470
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLvvdDLDNALELAKKLRPGYRIVTldgDLVRPGGVITGGS-A 666

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1471 DAAKTIQDKNKEIERLKQLIDKetndrkcLEDENARLQRVQYDLQKANSSATETINKLKVQEQEltrlridyervsqert 1550
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEE-------LEEKIAELEKALAELRKELEELEEELEQLRKELEE---------------- 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1551 vKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQAsivkkrsE 1630
Cdd:TIGR02168  724 -LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL-------K 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1631 DDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLT 1710
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESEL 875

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1711 ENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNatilELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQKQ 1790
Cdd:TIGR02168  876 EALLNERASLEEALALLRSELEELSEELRELESKRS----ELRRELE-------ELREKLAQLELRLEGLEVRIDNLQER 944

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1791 ALEASNRIQEsknqctqVVQERESLLV-KIKVLEQDKARLQRLEDELNRAKSTLEAETR-VKQRLECEKQQIqNDLNQWK 1868
Cdd:TIGR02168  945 LSEEYSLTLE-------EAEALENKIEdDEEEARRRLKRLENKIKELGPVNLAAIEEYEeLKERYDFLTAQK-EDLTEAK 1016

                          890
                   ....*....|...
gi 1147813    1869 TQYsrkEEAIRKI 1881
Cdd:TIGR02168 1017 ETL---EEAIEEI 1026
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 447-513 2.28e-26

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 103.88  E-value: 2.28e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813     447 QLKPRNpdYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIP 513
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1320-1910 1.12e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 103.48  E-value: 1.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1320 IQDKNKEIERLKAEfQEEAKRRWEYENELSKVRNNY----DEEIISLKNQFETEINITKTTIHQLTMQKEEDtsgyRAQI 1395
Cdd:COG1196  195 LGELERQLEPLERQ-AEKAERYRELKEELKELEAELlllkLRELEAELEELEAELEELEAELEELEAELAEL----EAEL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1396 DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT 1475
Cdd:COG1196  270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1476 IQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQD 1555
Cdd:COG1196  350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1556 ITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED---- 1631
Cdd:COG1196  430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGfleg 509

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1632 ----DLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAiedKSRSLNESKIEIERLQ 1707
Cdd:COG1196  510 vkaaLLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAK---AGRATFLPLDKIRARA 586

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1708 SLTENLTKEHLMLEEELRNLRLEYDDLRRgRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKF 1787
Cdd:COG1196  587 ALAAALARGAIGAAVDLVASDLREADARY-YVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGG 665

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1788 QKQALEASNRIQEsknqcTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQW 1867
Cdd:COG1196  666 SRRELLAALLEAE-----AELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEE 740

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|...
gi 1147813  1868 KTQYsrkEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1910
Cdd:COG1196  741 LLEE---EELLEEEALEELPEPPDLEELERELERLEREIEALG 780
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1149-1881 2.06e-20

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 99.41  E-value: 2.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1149 EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYEtEINITK---TTIKEIS 1225
Cdd:pfam05483   86 EAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIK-ENNATRhlcNLLKETC 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1226 MQKEDDSKNLRNQLDRLSRENRDLKDEIVRLndsILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQvmqqrsED 1305
Cdd:pfam05483  165 ARSAEKTKKYEYEREETRQVYMDLNNNIEKM---ILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKK------EI 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1306 NARHKQSLEEAAKTIQDKNK--------EIERLKA-EFQEEAKRRWEYENELSKVRNNYDEEI----------ISLKNQF 1366
Cdd:pfam05483  236 NDKEKQVSLLLIQITEKENKmkdltfllEESRDKAnQLEEKTKLQDENLKELIEKKDHLTKELedikmslqrsMSTQKAL 315

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1367 ETEINITKTTIHQLTMQKEedtsgyrAQIDNLTRENRSLSEEIKRLKNTlTQTTENLRRVEEdiqqqkatgsevsQRKQQ 1446
Cdd:pfam05483  316 EEDLQIATKTICQLTEEKE-------AQMEELNKAKAAHSFVVTEFEAT-TCSLEELLRTEQ-------------QRLEK 374

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1447 LEVELRQVTQMRTEESvrykQSLDDAAKTIQDKNKEIERLKQLIdketNDRKCLEDENARLQRVQYDLQkanSSATETIN 1526
Cdd:pfam05483  375 NEDQLKIITMELQKKS----SELEEMTKFKNNKEVELEELKKIL----AEDEKLLDEKKQFEKIAEELK---GKEQELIF 443

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1527 KLKVQEQELTRLRIDYERVSqertvkdqdiTRFQNSLKELQLQKQKVE-EELNRLKRTASED--SCKRKKLEEELEGMRR 1603
Cdd:pfam05483  444 LLQAREKEIHDLEIQLTAIK----------TSEEHYLKEVEDLKTELEkEKLKNIELTAHCDklLLENKELTQEASDMTL 513

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1604 SLKEQAIKITNLTQQLEQAsivkkrseddlrqqrdvldghLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNE 1683
Cdd:pfam05483  514 ELKKHQEDIINCKKQEERM---------------------LKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSE 572

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1684 HFQKAIE----DKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQIS 1759
Cdd:pfam05483  573 ENARSIEyevlKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKF 652

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1760 NNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKvlEQDKARLQRLEDELNRA 1839
Cdd:pfam05483  653 EEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHK--HQYDKIIEERDSELGLY 730

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 1147813    1840 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKI 1881
Cdd:pfam05483  731 KNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKL 772
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1313-1942 7.71e-17

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 87.81  E-value: 7.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1313 LEEAAKTIQDKNKEIERLKAEFQEEAKRrweyenelskvrnnyDEEIISLKNQFETEINITKTTIHQLtMQKEEDTSGYR 1392
Cdd:PRK03918  160 YENAYKNLGEVIKEIKRRIERLEKFIKR---------------TENIEELIKEKEKELEEVLREINEI-SSELPELREEL 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1393 AQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMR--TEESVRYKQSLD 1470
Cdd:PRK03918  224 EKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKekAEEYIKLSEFYE 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1471 DAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQrvqyDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERT 1550
Cdd:PRK03918  304 EYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLE----ELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKK 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1551 -VKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQlEQASIVKKRS 1629
Cdd:PRK03918  380 rLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEE-HRKELLEEYT 458

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1630 EDdlrqqrdvLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEhfQKAIEDKSRSLNesKIEIERLQSL 1709
Cdd:PRK03918  459 AE--------LKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQ--LKELEEKLKKYN--LEELEKKAEE 526

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1710 TENLTKEHLMLEEELRNLRleyDDLRRgrseadsdknatilelrsqLQISNNRTLELQGLINDLQRERENLRQEIEKFQK 1789
Cdd:PRK03918  527 YEKLKEKLIKLKGEIKSLK---KELEK-------------------LEELKKKLAELEKKLDELEEELAELLKELEELGF 584

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1790 QALEASNRiqesknqctqVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKT 1869
Cdd:PRK03918  585 ESVEELEE----------RLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEK 654

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1147813   1870 QYSrkEEAIRKIESEREksereknSLRSEIERLQAEIKRIEERcRRKLEDSTRETQSQLEtERSRYQREIDKL 1942
Cdd:PRK03918  655 KYS--EEEYEELREEYL-------ELSRELAGLRAELEELEKR-REEIKKTLEKLKEELE-EREKAKKELEKL 716
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2291-2329 1.33e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 69.66  E-value: 1.33e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2291 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKL 2329
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2367-2405 2.31e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 68.89  E-value: 2.31e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2367 LLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEIL 2405
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2650-2686 1.03e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 66.97  E-value: 1.03e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1147813    2650 LLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMAT 2686
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQ 37
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2124-2162 1.66e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 63.89  E-value: 1.66e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2124 LLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSL 2162
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2048-2086 3.46e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 62.73  E-value: 3.46e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2048 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQI 2086
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 285-450 6.19e-11

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 64.77  E-value: 6.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:cd00176   15 WLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELREL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   365 TKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKErekILEYKRQVQNLVNKSKK 444
Cdd:cd00176   95 AEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEE---LEAHEPRLKSLNELAEE 171


                 ....*.
gi 1147813   445 IVQLKP 450
Cdd:cd00176  172 LLEEGH 177
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2726-2764 6.84e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 56.18  E-value: 6.84e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2726 FLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRL 2764
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
2648-2685 1.07e-09

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 55.57  E-value: 1.07e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2648 QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2685
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2724-2757 5.37e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 50.94  E-value: 5.37e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1147813     2724 QRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFID 2757
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLID 34
PLEC smart00250
Plectin repeat;
2084-2121 3.42e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.63  E-value: 3.42e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETG 2121
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2468-2496 3.52e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 48.48  E-value: 3.52e-07
                           10        20
                   ....*....|....*....|....*....
gi 1147813    2468 IVDPETNKEMSVQEAYKKGLIDYETFKEL 2496
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
2048-2083 4.16e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.25  E-value: 4.16e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1147813     2048 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2291-2325 9.56e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 47.48  E-value: 9.56e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1147813     2291 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEF 2325
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 190-366 1.23e-06

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 52.06  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   190 ECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA---DLREKSAIY---------QLEEEYEN 257
Cdd:cd00176   11 ELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNElgeQLIEEGHPDaeeiqerleELNQRWEE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   258 LLKASFERMDHL---RQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESD 334
Cdd:cd00176   91 LRELAEERRQRLeeaLDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSLNELAE 170

                        170       180       190
                 ....*....|....*....|....*....|...
gi 1147813   335 QLVLNQHPAS-DKIEAYMDTLQTQWSWILQITK 366
Cdd:cd00176  171 ELLEEGHPDAdEEIEEKLEELNERWEELLELAE 203
PLEC smart00250
Plectin repeat;
2251-2288 2.48e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.32  E-value: 2.48e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2251 KDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTA 2288
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2365-2400 9.21e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 9.21e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1147813     2365 IRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEE 2400
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
PLEC smart00250
Plectin repeat;
2463-2493 1.20e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 1.20e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1147813     2463 KRRVVIVDPETNKEMSVQEAYKKGLIDYETF 2493
Cdd:smart00250    8 SAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
growth_prot_Scy NF041483
polarized growth protein Scy;
1200-1963 1.78e-05

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 50.59  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1200 NEEMSNLRNKYETEINITKTTIKEISMQ----KEDDSKNLRNQLDRLSRENRDLKDEIVRLN-DSILQATEQRRRAEENA 1274
Cdd:NF041483  392 AEEAERIRREAEAEADRLRGEAADQAEQlkgaAKDDTKEYRAKTVELQEEARRLRGEAEQLRaEAVAEGERIRGEARREA 471

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1275 LQQ----KACGSEIMQKKQHLEIELKQVMQQ-----RSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKR-RWEY 1344
Cdd:NF041483  472 VQQieeaARTAEELLTKAKADADELRSTATAeservRTEAIERATTLRRQAEETLERTRAEAERLRAEAEEQAEEvRAAA 551

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1345 ENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENrslSEEIKRLKntlTQTTENLR 1424
Cdd:NF041483  552 ERAARELREETERAIAARQAEAAEELTRLHTEAEERLTAAEEALADARAEAERIRREA---AEETERLR---TEAAERIR 625

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1425 rveeDIQQQKATGSEvsqrkqqlevelrqvtQMRTEESVRYKQSLDD----AAKTIQDKNKEIERLKQLIdKETNDRKCL 1500
Cdd:NF041483  626 ----TLQAQAEQEAE----------------RLRTEAAADASAARAEgenvAVRLRSEAAAEAERLKSEA-QESADRVRA 684

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1501 EDENARlQRVQYDLQKANSSAtetinklkvQEQELTRLRIDYERVSQERTVKDQditrfqnslkELQLQKQKVEEELnrl 1580
Cdd:NF041483  685 EAAAAA-ERVGTEAAEALAAA---------QEEAARRRREAEETLGSARAEADQ----------ERERAREQSEELL--- 741

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1581 krtasedSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASivkkrseddlRQQRDVLDGhLREKqrTQEELRRLSSE 1660
Cdd:NF041483  742 -------ASARKRVEEAQAEAQRLVEEADRRATELVSAAEQTA----------QQVRDSVAG-LQEQ--AEEEIAGLRSA 801

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1661 VE----ALRRQLLQEQESVK-QAHLRNEhfqKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDdlR 1735
Cdd:NF041483  802 AEhaaeRTRTEAQEEADRVRsDAYAERE---RASEDANRLRREAQEETEAAKALAERTVSEAIAEAERLRSDASEYA--Q 876

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1736 RGRSEAdSDKNATILElrsqlqisnnrtlelqglinDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESL 1815
Cdd:NF041483  877 RVRTEA-SDTLASAEQ--------------------DAARTRADAREDANRIRSDAAAQADRLIGEATSEAERLTAEARA 935

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1816 LVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQiqndlnqwkTQYSRKEEAIRkiesereksereknsL 1895
Cdd:NF041483  936 EAERLRDEARAEAERVRADAAAQAEQLIAEATGEAERLRAEAAE---------TVGSAQQHAER---------------I 991

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1896 RSEIERLQAEIKRIEERCRR-------KLEDSTRETQS--------QLETERSRYQREIDKLRQRPYGSHRETQTECEWT 1960
Cdd:NF041483  992 RTEAERVKAEAAAEAERLRTeareeadRTLDEARKDANkrrseaaeQADTLITEAAAEADQLTAKAQEEALRTTTEAEAQ 1071


                  ...
gi 1147813   1961 VDT 1963
Cdd:NF041483 1072 ADT 1074
PLEC smart00250
Plectin repeat;
2328-2364 1.80e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.62  E-value: 1.80e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1147813     2328 KLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 2364
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2123-2159 1.80e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.62  E-value: 1.80e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1147813     2123 RLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 2159
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2253-2291 1.96e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 43.86  E-value: 1.96e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2253 FLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALEL 2291
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
2611-2647 1.00e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.70  E-value: 1.00e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1147813     2611 DTLEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2647
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
growth_prot_Scy NF041483
polarized growth protein Scy;
1256-1938 1.32e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 47.90  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1256 LNDSILQATEQRRRAEENALQQKACGSEIMQK----KQHLEIELKQVMQQRSEdnaRHKQSLEEAAKTIQDKNKE----I 1327
Cdd:NF041483   78 LRNAQIQADQLRADAERELRDARAQTQRILQEhaehQARLQAELHTEAVQRRQ---QLDQELAERRQTVESHVNEnvawA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1328 ERLKAEFQEEAKR-----RWEYENELSKVRNnydeeiislknqfETEiNITKTTIHQLTMQKEEDtsgyRAQIDNLTREN 1402
Cdd:NF041483  155 EQLRARTESQARRlldesRAEAEQALAAARA-------------EAE-RLAEEARQRLGSEAESA----RAEAEAILRRA 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1403 RSLSEeikRLKNTL-TQTTENLRRVEediQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNK 1481
Cdd:NF041483  217 RKDAE---RLLNAAsTQAQEATDHAE---QLRSSTAAESDQARRQAAELSRAAEQRMQEAEEALREARAEAEKVVAEAKE 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1482 EIErlKQLIDKE-TNDRKC--LEDENARLqrVQYDLQKANSSATETinklkvqEQELTRLRIDYERVSQERTVKDQDITR 1558
Cdd:NF041483  291 AAA--KQLASAEsANEQRTrtAKEEIARL--VGEATKEAEALKAEA-------EQALADARAEAEKLVAEAAEKARTVAA 359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1559 fQNSLKELQLQKQKVEEELNRlkrtASEDS-CKRKKLEEELEGMRRSLKEQAIKITnlTQQLEQASIVKKRSEDDLRQQR 1637
Cdd:NF041483  360 -EDTAAQLAKAARTAEEVLTK----ASEDAkATTRAAAEEAERIRREAEAEADRLR--GEAADQAEQLKGAAKDDTKEYR 432

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1638 dvldghlREKQRTQEELRRLSSEVEALRRQLLQEQESVKqAHLRNEHFQKaIEDKSRSLneskieierlqsltenltkeh 1717
Cdd:NF041483  433 -------AKTVELQEEARRLRGEAEQLRAEAVAEGERIR-GEARREAVQQ-IEEAARTA--------------------- 482

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1718 lmlEEELRNLRLEYDDLRRGRSeADSDKNAT-ILELRSQLQISNNRTLElqglindlqrereNLRQEIEKFQKQALEASN 1796
Cdd:NF041483  483 ---EELLTKAKADADELRSTAT-AESERVRTeAIERATTLRRQAEETLE-------------RTRAEAERLRAEAEEQAE 545

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1797 RIQESKNQCTQVVQERESLLVKikvleqdkARLQRLEDELNRAKStlEAETRVkqrlecekqqiqndlnqwktqySRKEE 1876
Cdd:NF041483  546 EVRAAAERAARELREETERAIA--------ARQAEAAEELTRLHT--EAEERL----------------------TAAEE 593

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813   1877 AIrkieserekserekNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1938
Cdd:NF041483  594 AL--------------ADARAEAERIRREAAEETERLRTEAAERIRTLQAQAEQEAERLRTE 641
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1160-1534 1.69e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.32  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1160 SEKAIKEKEYEIERLRVLLQEEGTRKREYEN-----ELAKVRNHYNEEMSNLRNKYETEIniTKTTIKEISMQKEDDSKN 1234
Cdd:NF033838   56 QKEHAKEVESHLEKILSEIQKSLDKRKHTQNvalnkKLSDIKTEYLYELNVLKEKSEAEL--TSKTKKELDAAFEQFKKD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1235 LRNQLDRLSRENRDLKDEIVRLNDsilQATEQRRRAEENA---LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQ 1311
Cdd:NF033838  134 TLEPGKKVAEATKKVEEAEKKAKD---QKEEDRRNYPTNTyktLELEIAESDVEVKKAELELVKEEAKEPRDEEKIKQAK 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1312 SLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHqltmQKEEDTSGY 1391
Cdd:NF033838  211 AKVESKKAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPD----KKENDAKSS 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1392 RAQIDNLTRENRSLSEEIKrlkntltqTTENLRRVEEdiQQQKATGSEVSQRK-------QQLEVELrqvtqmrTEESVR 1464
Cdd:NF033838  287 DSSVGEETLPSPSLKPEKK--------VAEAEKKVEE--AKKKAKDQKEEDRRnyptntyKTLELEI-------AESDVK 349

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1465 YKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKcledENARLQRVQYDLQKANSSAtetinKLKVQEQE 1534
Cdd:NF033838  350 VKEAELELVKEEAKEPRNEEKIKQAKAKVESKKA----EATRLEKIKTDRKKAEEEA-----KRKAAEED 410
SPEC smart00150
Spectrin repeats;
285-373 1.89e-04

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 42.70  E-value: 1.89e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813      285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:smart00150   13 WLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLEELNERWEELKEL 92


                    ....*....
gi 1147813      365 TKCIDVHLK 373
Cdd:smart00150   93 AEERRQKLE 101
growth_prot_Scy NF041483
polarized growth protein Scy;
1121-1915 4.10e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 46.36  E-value: 4.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1121 EKRRRKSVEDRFDQ----QKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLR--------------------- 1175
Cdd:NF041483  352 EKARTVAAEDTAAQlakaARTAEEVLTKASEDAKATTRAAAEEAERIRREAEAEADRLRgeaadqaeqlkgaakddtkey 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1176 ----VLLQEEGTRKReyeNELAKVRNHYNEEMSNLRNKYETE----INITKTTIKEISMQKEDDSKNLRNQLDRLSrenr 1247
Cdd:NF041483  432 raktVELQEEARRLR---GEAEQLRAEAVAEGERIRGEARREavqqIEEAARTAEELLTKAKADADELRSTATAES---- 504

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1248 dlkdEIVRlNDSILQATEQRRRAEENALQQKAcgseimQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKN--- 1324
Cdd:NF041483  505 ----ERVR-TEAIERATTLRRQAEETLERTRA------EAERLRAEAEEQAEEVRAAAERAARELREETERAIAARQaea 573

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1325 -KEIERLKAEFQE--------------EAKR-RWEYENELSKVRNNYDEEIISLKNQFETEINitkttihQLTMQKEEDT 1388
Cdd:NF041483  574 aEELTRLHTEAEErltaaeealadaraEAERiRREAAEETERLRTEAAERIRTLQAQAEQEAE-------RLRTEAAADA 646

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1389 SGYRAQIDNLTRENRS-LSEEIKRLKNTLTQTTENLR--------RVEEDIQQQKATGSEVSQRKQQLEVELrqVTQMRT 1459
Cdd:NF041483  647 SAARAEGENVAVRLRSeAAAEAERLKSEAQESADRVRaeaaaaaeRVGTEAAEALAAAQEEAARRRREAEET--LGSARA 724

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1460 E-----ESVRyKQS---LDDAAKTIQDKNKEIERLKqlidkETNDRKCLEDENARLQRVQydlqkansSATETINKLKVQ 1531
Cdd:NF041483  725 EadqerERAR-EQSeelLASARKRVEEAQAEAQRLV-----EEADRRATELVSAAEQTAQ--------QVRDSVAGLQEQ 790

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1532 -EQELTRLRIDYERVSQE-RTVKDQDITRFQNslkELQLQKQKVEEELNRLKRTASEDSCKRKKLEE--------ELEGM 1601
Cdd:NF041483  791 aEEEIAGLRSAAEHAAERtRTEAQEEADRVRS---DAYAERERASEDANRLRREAQEETEAAKALAErtvseaiaEAERL 867

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1602 RRSLKEQAIKI-TNLTQQLEQASIVKKRSEDDLRQ-----------QRDVLDGHLR-EKQRTQEELRrlsSEVEALRRQL 1668
Cdd:NF041483  868 RSDASEYAQRVrTEASDTLASAEQDAARTRADAREdanrirsdaaaQADRLIGEATsEAERLTAEAR---AEAERLRDEA 944

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1669 LQEQESVKQahlrnehfqKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNlrleydDLRRGRSEADsdknAT 1748
Cdd:NF041483  945 RAEAERVRA---------DAAAQAEQLIAEATGEAERLRAEAAETVGSAQQHAERIRT------EAERVKAEAA----AE 1005

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1749 ILELRSQLQISNNRTLelqglinDLQRERENLRQeiekfQKQALEASNRIQESKNQCTQVVQE--RESLLVKIKVLEQDK 1826
Cdd:NF041483 1006 AERLRTEAREEADRTL-------DEARKDANKRR-----SEAAEQADTLITEAAAEADQLTAKaqEEALRTTTEAEAQAD 1073

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1827 ARL--QRLEDELNRAKSTLEAETRVkqrlecekQQIQNDLNQWKTQYSRKEEAIRKieserekserEKNSLRseiERLQA 1904
Cdd:NF041483 1074 TMVgaARKEAERIVAEATVEGNSLV--------EKARTDADELLVGARRDATAIRE----------RAEELR---DRITG 1132

                         890
                  ....*....|.
gi 1147813   1905 EIKRIEERCRR 1915
Cdd:NF041483 1133 EIEELHERARR 1143
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1013-1347 6.34e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 45.39  E-value: 6.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1013 YYRFLSEMLKSLE----------DLKLKNTKIEVLEEELRLARDANSENCNKNKF-LDQNLQKYQAECSQFKAKLASLEE 1081
Cdd:NF033838   67 LEKILSEIQKSLDkrkhtqnvalNKKLSDIKTEYLYELNVLKEKSEAELTSKTKKeLDAAFEQFKKDTLEPGKKVAEATK 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1082 LKRQAELDGKSAKQNLDKCYgqikelnEKITRLTYEIEDEKRRRKSVEDRFDQQKndyDQLQKARQCEKENLGWQKLESE 1161
Cdd:NF033838  147 KVEEAEKKAKDQKEEDRRNY-------PTNTYKTLELEIAESDVEVKKAELELVK---EEAKEPRDEEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKeismQKEDDSKNLRNQLDR 1241
Cdd:NF033838  217 KAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPD----KKENDAKSSDSSVGE 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1242 LSRENRDLKDEivrlnDSILQATEQRRRAEENALQQKA------------------CGSEIMQKKQHLEIELKQVMQQRS 1303
Cdd:NF033838  293 ETLPSPSLKPE-----KKVAEAEKKVEEAKKKAKDQKEedrrnyptntyktleleiAESDVKVKEAELELVKEEAKEPRN 367

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1147813   1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENE 1347
Cdd:NF033838  368 EEKIKQAKAKVESKKAEATRLEKIKTDRKKAEEEAKRKAAEEDK 411
PLEC smart00250
Plectin repeat;
2762-2799 4.77e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.08  E-value: 4.77e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2762 QRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG 2799
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1311-1405 6.08e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 41.41  E-value: 6.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1311 QSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINIT-----KTTIHQLTMQKE 1385
Cdd:cd16269  191 QALTEKEKEIEAERAKAEAAEQERKLLEEQQRELEQKLEDQERSYEEHLRQLKEKMEEERENLlkeqeRALESKLKEQEA 270

                         90       100
                 ....*....|....*....|
gi 1147813  1386 EDTSGYRAQIDNLTRENRSL 1405
Cdd:cd16269  271 LLEEGFKEQAELLQEEIRSL 290
PRK01156 PRK01156
chromosome segregation protein; Provisional
 707-1281 8.02e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.81  E-value: 8.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    707 NELKSVQNDSQAIAEVLNQLKDMLANF-----RGSEKYCYLQNEVFGLFQKLENINGVTDgYLNSLCTVRALLQAILQTE 781
Cdd:PRK01156  190 EKLKSSNLELENIKKQIADDEKSHSITlkeieRLSIEYNNAMDDYNNLKSALNELSSLED-MKNRYESEIKTAESDLSME 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    782 DMLKVYEARLtEEETVCLDLDKVEAYR---CGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSqqyplydlDLGKfge 858
Cdd:PRK01156  269 LEKNNYYKEL-EERHMKIINDPVYKNRnyiNDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLS--------VLQK--- 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    859 kvtqltDRWQRIDKQIdfRLWDLEKQIKQLRNYRDNYQAFCKWLYDRKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
Cdd:PRK01156  337 ------DYNDYIKKKS--RYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIK 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    939 GKRdksEEVQKiaelcanSIKDYELQLASYTSGLETLLN--IPIKRTM-IQSPSGVILQEAADVHARYIELLTRsgDYYr 1015
Cdd:PRK01156  409 KEL---NEINV-------KLQDISSKVSSLNQRIRALREnlDELSRNMeMLNGQSVCPVCGTTLGEEKSNHIIN--HYN- 475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1016 flsemlkslEDLKLKNTKIEVLEEElrlARDANSENCNKNKFLD----QNLQKYQAECSQFKAKLASLEELK-RQAELDG 1090
Cdd:PRK01156  476 ---------EKKSRLEEKIREIEIE---VKDIDEKIVDLKKRKEylesEEINKSINEYNKIESARADLEDIKiKINELKD 543

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1091 KSAKQNldkcygqikELNEKITRLTYEIEDEKR----RRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES------ 1160
Cdd:PRK01156  544 KHDKYE---------EIKNRYKSLKLEDLDSKRtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIgfpddk 614

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1161 ---EKAIKEKEYEIERLRVLLQEEGTRKREYEnELAKVRNHYNEEMSNLRnkyetEINITKTTIKEISMQKEDDSKNLRN 1237
Cdd:PRK01156  615 syiDKSIREIENEANNLNNKYNEIQENKILIE-KLRGKIDNYKKQIAEID-----SIIPDLKEITSRINDIEDNLKKSRK 688

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1147813   1238 QLD-------RLSRENRDLKDEIVRLNDSIlqaTEQRRRAEENALQQKACG 1281
Cdd:PRK01156  689 ALDdakanraRLESTIEILRTRINELSDRI---NDINETLESMKKIKKAIG 736
growth_prot_Scy NF041483
polarized growth protein Scy;
1223-1956 9.56e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.74  E-value: 9.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1223 EISMQKEDDSKNLRNQLDRL----SRENRDLKDEIVRlndsILQateqrRRAEENALQQKACGSEIMQKKQHLEIELKQV 1298
Cdd:NF041483   69 DIGYQAEQLLRNAQIQADQLradaERELRDARAQTQR----ILQ-----EHAEHQARLQAELHTEAVQRRQQLDQELAER 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1299 MQQ-----------------RSEDNARH--KQSLEEAAKTIQDKNKEIERLKaefqEEAKRRWEYENELSKV-------R 1352
Cdd:NF041483  140 RQTveshvnenvawaeqlraRTESQARRllDESRAEAEQALAAARAEAERLA----EEARQRLGSEAESARAeaeailrR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1353 NNYDEEiiSLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTR--ENRsLSEEIKRLKNTLTQTTENLRRVEEDI 1430
Cdd:NF041483  216 ARKDAE--RLLNAASTQAQEATDHAEQLRSSTAAESDQARRQAAELSRaaEQR-MQEAEEALREARAEAEKVVAEAKEAA 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1431 QQQKATG-SEVSQRKQQLEVELRQVTQMRTEESVRYK----QSLDDA---AKTIQDKNKEIERLKQLIDKETNDRKCLED 1502
Cdd:NF041483  293 AKQLASAeSANEQRTRTAKEEIARLVGEATKEAEALKaeaeQALADAraeAEKLVAEAAEKARTVAAEDTAAQLAKAART 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1503 ENARLQRVQYDLQKANSSATETINKLKVQ-EQELTRLRIDYERVSQERTVKDQDITrfqnslKELQLQKQKVEEELNRLK 1581
Cdd:NF041483  373 AEEVLTKASEDAKATTRAAAEEAERIRREaEAEADRLRGEAADQAEQLKGAAKDDT------KEYRAKTVELQEEARRLR 446

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1582 RTASEdscKRKKLEEELEGMRRSLKEQAIkitnltQQLEQAS------IVKKRSE-DDLRQQRDVLDGHLRE-------- 1646
Cdd:NF041483  447 GEAEQ---LRAEAVAEGERIRGEARREAV------QQIEEAArtaeelLTKAKADaDELRSTATAESERVRTeaieratt 517

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1647 -KQRTQEELRRLSSEVEALRRQLLQEQESVKQA------HLRNEHfQKAIEDKSrslNESKIEIERLQSLTEnltkEHLM 1719
Cdd:NF041483  518 lRRQAEETLERTRAEAERLRAEAEEQAEEVRAAaeraarELREET-ERAIAARQ---AEAAEELTRLHTEAE----ERLT 589

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1720 -LEEELRNLRLEYDDLRRGRSEaDSDKNATILELRSqlqisnnRTLELQGlindlQRERENLRQEiekfqkQALEASNRI 1798
Cdd:NF041483  590 aAEEALADARAEAERIRREAAE-ETERLRTEAAERI-------RTLQAQA-----EQEAERLRTE------AAADASAAR 650

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1799 QESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDEL------NRAKSTLEA--ETRVKQRLECEKqqiqndlnqwkTQ 1870
Cdd:NF041483  651 AEGENVAVRLRSEAAAEAERLKSEAQESADRVRAEAAAaaervgTEAAEALAAaqEEAARRRREAEE-----------TL 719

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1871 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR-IEERCRRKLE-------------DSTRETQSQLETE----- 1931
Cdd:NF041483  720 GSARAEADQERERAREQSEELLASARKRVEEAQAEAQRlVEEADRRATElvsaaeqtaqqvrDSVAGLQEQAEEEiaglr 799

                         810       820       830
                  ....*....|....*....|....*....|....*
gi 1147813   1932 ----------RSRYQREIDKLRQRPYgSHRETQTE 1956
Cdd:NF041483  800 saaehaaertRTEAQEEADRVRSDAY-AERERASE 833
 
Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 548-625 5.16e-35

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 465730  Cd Length: 78  Bit Score: 129.26  E-value: 5.16e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813     548 VSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQ 625
Cdd:pfam18373    1 VSWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1014-1881 2.75e-31

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 135.18  E-value: 2.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1014 YRFLSEMLKSLEdLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSA 1093
Cdd:TIGR02168  215 YKELKAELRELE-LALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYAL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1094 KQNLDKCYGQIKELNEK-------ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKarqcekenlgwqKLESEKAike 1166
Cdd:TIGR02168  294 ANEISRLEQQKQILRERlanlerqLEELEAQLEELESKLDELAEELAELEEKLEELKE------------ELESLEA--- 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1167 keyEIERLRVLLQEEGTRKREYENELAKVRNHYNEeMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSR-E 1245
Cdd:TIGR02168  359 ---ELEELEAELEELESRLEELEEQLETLRSKVAQ-LELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaE 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1246 NRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS--EDNARHKQSLEEAAKTIQDK 1323
Cdd:TIGR02168  435 LKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDslERLQENLEGFSEGVKALLKN 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1324 NKEIERLKAEFQEEAKRRWEYENELSKV----RNNY---DEEIISLKNQFETEINITKTTIHQLTMQKEedtsgyrAQID 1396
Cdd:TIGR02168  515 QSGLSGILGVLSELISVDEGYEAAIEAAlggrLQAVvveNLNAAKKAIAFLKQNELGRVTFLPLDSIKG-------TEIQ 587

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1397 NLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA---TGSEVSQRKQQLEVELRQVT---QMRTEESVRYKQSlD 1470
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLvvdDLDNALELAKKLRPGYRIVTldgDLVRPGGVITGGS-A 666

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1471 DAAKTIQDKNKEIERLKQLIDKetndrkcLEDENARLQRVQYDLQKANSSATETINKLKVQEQEltrlridyervsqert 1550
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEE-------LEEKIAELEKALAELRKELEELEEELEQLRKELEE---------------- 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1551 vKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQAsivkkrsE 1630
Cdd:TIGR02168  724 -LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL-------K 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1631 DDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLT 1710
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESEL 875

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1711 ENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNatilELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQKQ 1790
Cdd:TIGR02168  876 EALLNERASLEEALALLRSELEELSEELRELESKRS----ELRRELE-------ELREKLAQLELRLEGLEVRIDNLQER 944

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1791 ALEASNRIQEsknqctqVVQERESLLV-KIKVLEQDKARLQRLEDELNRAKSTLEAETR-VKQRLECEKQQIqNDLNQWK 1868
Cdd:TIGR02168  945 LSEEYSLTLE-------EAEALENKIEdDEEEARRRLKRLENKIKELGPVNLAAIEEYEeLKERYDFLTAQK-EDLTEAK 1016

                          890
                   ....*....|...
gi 1147813    1869 TQYsrkEEAIRKI 1881
Cdd:TIGR02168 1017 ETL---EEAIEEI 1026
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 447-513 2.28e-26

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 103.88  E-value: 2.28e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813     447 QLKPRNpdYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIP 513
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1074-1912 2.42e-26

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 119.02  E-value: 2.42e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKsvedrFDQQKNDYDQLQKARqcEKENL 1153
Cdd:TIGR02169  163 AGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQA-----LLKEKREYEGYELLK--EKEAL 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1154 GWQKLESEKAIKEKEYEIERLRVLLQEEGTRKreyeNELAKVRNHYNEEmsnLRNKYETEINITKTTIKEISMQKEDDSK 1233
Cdd:TIGR02169  236 ERQKEAIERQLASLEEELEKLTEEISELEKRL----EEIEQLLEELNKK---IKDLGEEEQLRVKEKIGELEAEIASLER 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1234 NLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEiELKQVMQQRSEDNARHKQSL 1313
Cdd:TIGR02169  309 SIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELE-DLRAELEEVDKEFAETRDEL 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1314 EEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYdEEIISLKNQFETEINITKTTIHQLT---MQKEEDTSG 1390
Cdd:TIGR02169  388 KDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAI-AGIEAKINELEEEKEDKALEIKKQEwklEQLAADLSK 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1391 YRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQ-------QL-EVELRQVTQMRTEES 1462
Cdd:TIGR02169  467 YEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQgvhgtvaQLgSVGERYATAIEVAAG 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1463 VRYKQSL----DDAAKTIQ-DKNKEIER-----LKQLIDKETNDRKCLEDE--NARLQRVQYDLQKANSSATETINKLKV 1530
Cdd:TIGR02169  547 NRLNNVVveddAVAKEAIElLKRRKAGRatflpLNKMRDERRDLSILSEDGviGFAVDLVEFDPKYEPAFKYVFGDTLVV 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1531 QEQELTR-LRIDYERVSQERTVKDQD--ITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE 1607
Cdd:TIGR02169  627 EDIEAARrLMGKYRMVTLEGELFEKSgaMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDE 706

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1608 QAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQE-------ELRRLSSEVEALRRQLLQEQESVK--QA 1678
Cdd:TIGR02169  707 LSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQeienvksELKELEARIEELEEDLHKLEEALNdlEA 786

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1679 HLRNEHFQKaIEDKSRSLNESKIEIE-RLQSLTENLTKEHLMLE------EELRNLRLEYDDLRRGRSEADSDKNATILE 1751
Cdd:TIGR02169  787 RLSHSRIPE-IQAELSKLEEEVSRIEaRLREIEQKLNRLTLEKEylekeiQELQEQRIDLKEQIKSIEKEIENLNGKKEE 865

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1752 LRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQdkaRLQR 1831
Cdd:TIGR02169  866 LEEELE-------ELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEE---ELSE 935

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1832 LEDELNRAKSTLEAETRVKQrLECEKQQIQNDLnqwktqySRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEE 1911
Cdd:TIGR02169  936 IEDPKGEDEEIPEEELSLED-VQAELQRVEEEI-------RALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILE 1007


                   .
gi 1147813    1912 R 1912
Cdd:TIGR02169 1008 R 1008
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1122-1945 5.89e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 117.85  E-value: 5.89e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1122 KRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNE 1201
Cdd:TIGR02168  171 KERRKETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1202 eMSNLRNKYETEINITKTTIKEIsmqkEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
Cdd:TIGR02168  251 -AEEELEELTAELQELEEKLEEL----RLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1282 SEIMQKKQHLEIELKQVmqqrsednarhKQSLEEAAKTIQDKNKEIERLKAEfQEEAKRRWEyenELSKVRNNYDEEIIS 1361
Cdd:TIGR02168  326 EELESKLDELAEELAEL-----------EEKLEELKEELESLEAELEELEAE-LEELESRLE---ELEEQLETLRSKVAQ 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1362 LKNQFET---EINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRS-LSEEIKRLKNTLTQTTENLRRVEEDIQQQKATG 1437
Cdd:TIGR02168  391 LELQIASlnnEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKeLQAELEELEEELEELQEELERLEEALEELREEL 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1438 SEVSQRKQQLEVELRQVTQMRT--EESVRYKQSLDDAAKTIQDKNKEIE----RLKQLIDKETNDRKCLEdeNARLQRVQ 1511
Cdd:TIGR02168  471 EEAEQALDAAERELAQLQARLDslERLQENLEGFSEGVKALLKNQSGLSgilgVLSELISVDEGYEAAIE--AALGGRLQ 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1512 YDLQKANSSATETINKLKvqEQELTRLRIdyervSQERTVKDQDItrfQNSLKELQLQKQKVEEELNRLKrtasedsckr 1591
Cdd:TIGR02168  549 AVVVENLNAAKKAIAFLK--QNELGRVTF-----LPLDSIKGTEI---QGNDREILKNIEGFLGVAKDLV---------- 608

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1592 kKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKkrseddlRQQRDV-LDGHLrekqrtqeelrrlsseveaLRRQLLQ 1670
Cdd:TIGR02168  609 -KFDPKLRKALSYLLGGVLVVDDLDNALELAKKLR-------PGYRIVtLDGDL-------------------VRPGGVI 661

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1671 EQESVKQAHLRNEhfqkaiedKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRgrseADSDKNATIL 1750
Cdd:TIGR02168  662 TGGSAKTNSSILE--------RRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRK----ELEELSRQIS 729

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKnqcTQVVQERESLLVKIKVLEQDKARLQ 1830
Cdd:TIGR02168  730 ALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE---AEIEELEAQIEQLKEELKALREALD 806

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1831 RLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1910
Cdd:TIGR02168  807 ELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLE 886

                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 1147813    1911 ERC--RRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:TIGR02168  887 EALalLRSELEELSEELRELESKRSELRRELEELREK 923
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1159-1945 6.16e-23

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 107.85  E-value: 6.16e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1159 ESEKA---IKEKEYEIERLRVLLQEegtrKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEddskNL 1235
Cdd:TIGR02169  171 KKEKAleeLEEVEENIERLDLIIDE----KRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKE----AI 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1236 RNQLDRLSRENRDLKDEIVRLNDSILQAteqRRRAEENALQQKACGSEIM---QKKQH-LEIELKQVMQQRSEDNARHKQ 1311
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEI---EQLLEELNKKIKDLGEEEQlrvKEKIGeLEAEIASLERSIAEKERELED 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1312 SLEEAAKTIQDKNK---EIERLKAEFQEEAKRRWEYENELSKVRNNYdEEIISLKNQFETEINITKttihqltmqkeEDT 1388
Cdd:TIGR02169  320 AEERLAKLEAEIDKllaEIEELEREIEEERKRRDKLTEEYAELKEEL-EDLRAELEEVDKEFAETR-----------DEL 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1389 SGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQ--MRTEESV-RY 1465
Cdd:TIGR02169  388 KDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWklEQLAADLsKY 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1466 KQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKL-KVQEQELTRLRIDYER 1544
Cdd:TIGR02169  468 EQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLgSVGERYATAIEVAAGN 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1545 VSQERTVKDQDIT-RFQNSLKE--------LQLQKQKVEEelnRLKRTASEDSCKRKKLE-EELEGMRRSLKEQAIKITN 1614
Cdd:TIGR02169  548 RLNNVVVEDDAVAkEAIELLKRrkagratfLPLNKMRDER---RDLSILSEDGVIGFAVDlVEFDPKYEPAFKYVFGDTL 624

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1615 LTQQLEQAsivkKRSEDDLRQQrdVLDGHLREKQ------------------RTQEELRRLSSEVEALRRQLLQEQEsvK 1676
Cdd:TIGR02169  625 VVEDIEAA----RRLMGKYRMV--TLEGELFEKSgamtggsraprggilfsrSEPAELQRLRERLEGLKRELSSLQS--E 696

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1677 QAHLRNEHFQKaiedkSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNatilelrsql 1756
Cdd:TIGR02169  697 LRRIENRLDEL-----SQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELK---------- 761

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1757 qisnnrtlELQGLINDLQRERENLRQEIEKFQkqALEASNRIQESKNQCTQVVQERESLlvkikvleqdKARLQRLEDEL 1836
Cdd:TIGR02169  762 --------ELEARIEELEEDLHKLEEALNDLE--ARLSHSRIPEIQAELSKLEEEVSRI----------EARLREIEQKL 821

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1837 NRakstleaETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREksereknSLRSEIERLQAEIKRIEERcRRK 1916
Cdd:TIGR02169  822 NR-------LTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKE-------ELEEELEELEAALRDLESR-LGD 886

                          810       820       830
                   ....*....|....*....|....*....|..
gi 1147813    1917 LEDSTRETQSQLETERSRYQR---EIDKLRQR 1945
Cdd:TIGR02169  887 LKKERDELEAQLRELERKIEEleaQIEKKRKR 918
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1320-1910 1.12e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 103.48  E-value: 1.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1320 IQDKNKEIERLKAEfQEEAKRRWEYENELSKVRNNY----DEEIISLKNQFETEINITKTTIHQLTMQKEEDtsgyRAQI 1395
Cdd:COG1196  195 LGELERQLEPLERQ-AEKAERYRELKEELKELEAELlllkLRELEAELEELEAELEELEAELEELEAELAEL----EAEL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1396 DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT 1475
Cdd:COG1196  270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1476 IQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQD 1555
Cdd:COG1196  350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1556 ITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED---- 1631
Cdd:COG1196  430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGfleg 509

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1632 ----DLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAiedKSRSLNESKIEIERLQ 1707
Cdd:COG1196  510 vkaaLLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAK---AGRATFLPLDKIRARA 586

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1708 SLTENLTKEHLMLEEELRNLRLEYDDLRRgRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKF 1787
Cdd:COG1196  587 ALAAALARGAIGAAVDLVASDLREADARY-YVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGG 665

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1788 QKQALEASNRIQEsknqcTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQW 1867
Cdd:COG1196  666 SRRELLAALLEAE-----AELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEE 740

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|...
gi 1147813  1868 KTQYsrkEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1910
Cdd:COG1196  741 LLEE---EELLEEEALEELPEPPDLEELERELERLEREIEALG 780
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1414-1945 3.62e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 101.94  E-value: 3.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1414 NTLTQTTENLRRVEeDIQqqkatgSEVSQRKQQLEVELRQVTQMRT--EESVRYKQSLddAAKTIQDKNKEIERLKQLId 1491
Cdd:COG1196  179 RKLEATEENLERLE-DIL------GELERQLEPLERQAEKAERYRElkEELKELEAEL--LLLKLRELEAELEELEAEL- 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1492 ketndrkclEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQ 1571
Cdd:COG1196  249 ---------EELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLE 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1572 KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQ 1651
Cdd:COG1196  320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELA 399

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1652 EELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEY 1731
Cdd:COG1196  400 AQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAAL 479

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1732 DDLRRGRSEADSDKNATILELRSQLQISNN-------------------------------RTLELQGLINDLQRERENL 1780
Cdd:COG1196  480 AELLEELAEAAARLLLLLEAEADYEGFLEGvkaalllaglrglagavavligveaayeaalEAALAAALQNIVVEDDEVA 559

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1781 RQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI 1860
Cdd:COG1196  560 AAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRA 639

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1861 QNDlnqwKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREID 1940
Cdd:COG1196  640 VTL----AGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEE 715


                 ....*
gi 1147813  1941 KLRQR 1945
Cdd:COG1196  716 RLEEE 720
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1149-1881 2.06e-20

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 99.41  E-value: 2.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1149 EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYEtEINITK---TTIKEIS 1225
Cdd:pfam05483   86 EAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIK-ENNATRhlcNLLKETC 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1226 MQKEDDSKNLRNQLDRLSRENRDLKDEIVRLndsILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQvmqqrsED 1305
Cdd:pfam05483  165 ARSAEKTKKYEYEREETRQVYMDLNNNIEKM---ILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKK------EI 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1306 NARHKQSLEEAAKTIQDKNK--------EIERLKA-EFQEEAKRRWEYENELSKVRNNYDEEI----------ISLKNQF 1366
Cdd:pfam05483  236 NDKEKQVSLLLIQITEKENKmkdltfllEESRDKAnQLEEKTKLQDENLKELIEKKDHLTKELedikmslqrsMSTQKAL 315

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1367 ETEINITKTTIHQLTMQKEedtsgyrAQIDNLTRENRSLSEEIKRLKNTlTQTTENLRRVEEdiqqqkatgsevsQRKQQ 1446
Cdd:pfam05483  316 EEDLQIATKTICQLTEEKE-------AQMEELNKAKAAHSFVVTEFEAT-TCSLEELLRTEQ-------------QRLEK 374

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1447 LEVELRQVTQMRTEESvrykQSLDDAAKTIQDKNKEIERLKQLIdketNDRKCLEDENARLQRVQYDLQkanSSATETIN 1526
Cdd:pfam05483  375 NEDQLKIITMELQKKS----SELEEMTKFKNNKEVELEELKKIL----AEDEKLLDEKKQFEKIAEELK---GKEQELIF 443

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1527 KLKVQEQELTRLRIDYERVSqertvkdqdiTRFQNSLKELQLQKQKVE-EELNRLKRTASED--SCKRKKLEEELEGMRR 1603
Cdd:pfam05483  444 LLQAREKEIHDLEIQLTAIK----------TSEEHYLKEVEDLKTELEkEKLKNIELTAHCDklLLENKELTQEASDMTL 513

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1604 SLKEQAIKITNLTQQLEQAsivkkrseddlrqqrdvldghLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNE 1683
Cdd:pfam05483  514 ELKKHQEDIINCKKQEERM---------------------LKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSE 572

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1684 HFQKAIE----DKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQIS 1759
Cdd:pfam05483  573 ENARSIEyevlKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKF 652

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1760 NNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKvlEQDKARLQRLEDELNRA 1839
Cdd:pfam05483  653 EEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHK--HQYDKIIEERDSELGLY 730

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 1147813    1840 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKI 1881
Cdd:pfam05483  731 KNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKL 772
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1221-1966 3.57e-20

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 98.99  E-value: 3.57e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1221 IKEISMQKEDDSK--NLRNQLDRLSR--ENRDLKDEIVRLNDSILQatEQRRRAEE-NALQ---QKACGSEIMQKKQHLE 1292
Cdd:TIGR02169  159 IDEIAGVAEFDRKkeKALEELEEVEEniERLDLIIDEKRQQLERLR--REREKAERyQALLkekREYEGYELLKEKEALE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1293 IELKQVMQQRSEdnarHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRrweyenelskvrnnydeeiisLKNQFETEINI 1372
Cdd:TIGR02169  237 RQKEAIERQLAS----LEEELEKLTEEISELEKRLEEIEQLLEELNKK---------------------IKDLGEEEQLR 291

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1373 TKTTIHQLTMQKEEdtsgYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK----ATGSEVSQRKQQLE 1448
Cdd:TIGR02169  292 VKEKIGELEAEIAS----LERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERkrrdKLTEEYAELKEELE 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1449 VELRQVTQMRT------EESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDrkcLEDENARLQRVQYDLQKANSSAT 1522
Cdd:TIGR02169  368 DLRAELEEVDKefaetrDELKDYREKLEKLKREINELKRELDRLQEELQRLSEE---LADLNAAIAGIEAKINELEEEKE 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1523 ETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMR 1602
Cdd:TIGR02169  445 DKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVH 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1603 RSL------KEQAIKITNLTQQLEQASIVkkrSEDDLRQQRDVldGHLREKQRTQ------EELRRLSSEVEALRRqllq 1670
Cdd:TIGR02169  525 GTVaqlgsvGERYATAIEVAAGNRLNNVV---VEDDAVAKEAI--ELLKRRKAGRatflplNKMRDERRDLSILSE---- 595

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1671 eqESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLM-LEEELrnlrLEYDDLRRGRSEADSDKNATI 1749
Cdd:TIGR02169  596 --DGVIGFAVDLVEFDPKYEPAFKYVFGDTLVVEDIEAARRLMGKYRMVtLEGEL----FEKSGAMTGGSRAPRGGILFS 669

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1750 LELRSQLQISNNRTLELQGLINDLQREREN-------LRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVL 1822
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRienrldeLSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSL 749

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1823 EQ----DKARLQRLEDELNRAKSTL----EAETRVKQRLECEK-QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKN 1893
Cdd:TIGR02169  750 EQeienVKSELKELEARIEELEEDLhkleEALNDLEARLSHSRiPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKE 829

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1894 SLRSEIERLQAEIK----RIEERCR---------RKLEDSTRETQSQLETERSRY---QREIDKLRQRpYGSHRETQTEC 1957
Cdd:TIGR02169  830 YLEKEIQELQEQRIdlkeQIKSIEKeienlngkkEELEEELEELEAALRDLESRLgdlKKERDELEAQ-LRELERKIEEL 908


                   ....*....
gi 1147813    1958 EWTVDTSKL 1966
Cdd:TIGR02169  909 EAQIEKKRK 917
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1083-1794 7.85e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 97.70  E-value: 7.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1083 KRQAELDGKSAKQNLdkcygqikelnEKITRLTYEIEdekRRRKSVED------RFDQQKNDYDQLQ-KARQCEKENLGW 1155
Cdd:COG1196  174 KEEAERKLEATEENL-----------ERLEDILGELE---RQLEPLERqaekaeRYRELKEELKELEaELLLLKLRELEA 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1156 QKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEemsnLRNKYETEINITKTTIKEISMQKEDdSKNL 1235
Cdd:COG1196  240 ELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEE----AQAEEYELLAELARLEQDIARLEER-RREL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1236 RNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKacgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEE 1315
Cdd:COG1196  315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAE----AELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1316 AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSkvrnnydeeiislknqfeteinitkttihqltmQKEEDTSGYRAQI 1395
Cdd:COG1196  391 ALRAAAELAAQLEELEEAEEALLERLERLEEELE---------------------------------ELEEALAELEEEE 437

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1396 DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLddAAKT 1475
Cdd:COG1196  438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK--AALL 515

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1476 IQDKNKEIERLKQLIDKETNDRKCLE-------------DENARLQRVQYDLQKANSSAT----ETINKLKVQEQELTRL 1538
Cdd:COG1196  516 LAGLRGLAGAVAVLIGVEAAYEAALEaalaaalqnivveDDEVAAAAIEYLKAAKAGRATflplDKIRARAALAAALARG 595

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1539 RIDYERVSQERTVKDQDI--TRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEG---MRRSLKEQAIKIT 1613
Cdd:COG1196  596 AIGAAVDLVASDLREADAryYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGgslTGGSRRELLAALL 675

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1614 NLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS 1693
Cdd:COG1196  676 EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEE 755

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1694 R----SLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDdlrrgrseadsdknatilELRSQLqisnnrtlelqgl 1769
Cdd:COG1196  756 LpeppDLEELERELERLEREIEALGPVNLLAIEEYEELEERYD------------------FLSEQR------------- 804

                        730       740
                 ....*....|....*....|....*
gi 1147813  1770 iNDLQRERENLRQEIEKFQKQALEA 1794
Cdd:COG1196  805 -EDLEEARETLEEAIEEIDRETRER 828
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1064-1743 1.48e-19

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 96.24  E-value: 1.48e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1064 KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
Cdd:TIGR04523   30 KQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKIN 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1144 KARQCEKENLGWQKLESEKAIKEKEyEIERLRVLLQEEGTRKreyENELAKVRNHYN------EEMSNLRNKYETEINIT 1217
Cdd:TIGR04523  110 SEIKNDKEQKNKLEVELNKLEKQKK-ENKKNIDKFLTEIKKK---EKELEKLNNKYNdlkkqkEELENELNLLEKEKLNI 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1218 KTTIKEISMQKEDDSKNLRNqLDRLSRENRDLKDEIVRLNdsilqatEQRRRAEENALQQKacgSEIMQKKQHLEIELKQ 1297
Cdd:TIGR04523  186 QKNIDKIKNKLLKLELLLSN-LKKKIQKNKSLESQISELK-------KQNNQLKDNIEKKQ---QEINEKTTEISNTQTQ 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1298 VMQQrsednarhKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIIS-LKNQFETEINITKTT 1376
Cdd:TIGR04523  255 LNQL--------KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKeLKSELKNQEKKLEEI 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1377 IHQLTmQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQ 1456
Cdd:TIGR04523  327 QNQIS-QNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEK 405

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1457 MRTEESVRYKQslddAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQkanssatetiNKLKVQEQELT 1536
Cdd:TIGR04523  406 LNQQKDEQIKK----LQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLD----------NTRESLETQLK 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1537 RLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEElegmrrsLKEQAIKITNLT 1616
Cdd:TIGR04523  472 VLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESE-------KKEKESKISDLE 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1617 QQLEQASIVKKRSEddLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEhfqKAIEDKSRSL 1696
Cdd:TIGR04523  545 DELNKDDFELKKEN--LEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKE---KKISSLEKEL 619

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 1147813    1697 NESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADS 1743
Cdd:TIGR04523  620 EKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIK 666
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1028-1860 1.72e-19

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 96.58  E-value: 1.72e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1028 KLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107
Cdd:pfam02463  212 YYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLL 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1108 NEKITRLTYEIEDEKRRRKSVEdrfDQQKNDYDQLQKArqcEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKRE 1187
Cdd:pfam02463  292 AKEEEELKSELLKLERRKVDDE---EKLKESEKEKKKA---EKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQ 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1188 YENELAKvrnhyneemSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQR 1267
Cdd:pfam02463  366 EKLEQLE---------EELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEE 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1268 RRAEENALQQKACGSEImqKKQHLEIELKQVMQQRSEDNArhkqsleEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENE 1347
Cdd:pfam02463  437 ESIELKQGKLTEEKEEL--EKQELKLLKDELELKKSEDLL-------KETQLVKLQEQLELLLSRQKLEERSQKESKARS 507

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1348 LSKVrnnydeeiisLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVE 1427
Cdd:pfam02463  508 GLKV----------LLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGA 577

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1428 EDIQQQKATGSEVSQRKQQLEVELRqVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARL 1507
Cdd:pfam02463  578 RKLRLLIPKLKLPLKSIAVLEIDPI-LNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEE 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1508 QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQK-----VEEELNRLKR 1582
Cdd:pfam02463  657 GLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEElladrVQEAQDKINE 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1583 TASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVE 1662
Cdd:pfam02463  737 ELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAEL 816

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1663 ALRRQLLQEQESVKQAHLRNEHFQKAIEDKsRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEAD 1742
Cdd:pfam02463  817 LEEEQLLIEQEEKIKEEELEELALELKEEQ-KLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKE 895

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1743 SDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQA-----LEASNRIQESKNQCTQVVQERESLLV 1817
Cdd:pfam02463  896 KEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEadekeKEENNKEEEEERNKRLLLAKEELGKV 975

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|...
gi 1147813    1818 KIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI 1860
Cdd:pfam02463  976 NLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1235-1919 2.66e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 95.77  E-value: 2.66e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1235 LRNQLDRLSRE------NRDLKDEIVRLNDSILQATEQRRRAEENALQQKAcgseimqkkQHLEIELKQVMQQRSEDNAR 1308
Cdd:COG1196  198 LERQLEPLERQaekaerYRELKEELKELEAELLLLKLRELEAELEELEAEL---------EELEAELEELEAELAELEAE 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1309 hkqsLEEAAKTIQDKNKEIERLKAEFQEEAKRrweyenelskvrnnydeeiislKNQFETEINITKTTIHQLTMQKEEdt 1388
Cdd:COG1196  269 ----LEELRLELEELELELEEAQAEEYELLAE----------------------LARLEQDIARLEERRRELEERLEE-- 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1389 sgYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQvtqmRTEESVRYKQS 1468
Cdd:COG1196  321 --LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEE----LAEELLEALRA 394

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1469 LDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQE 1548
Cdd:COG1196  395 AAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL 474

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1549 RTVKDQDITRFQNSLKELQLQKQKVEEELNrlkrtASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKkR 1628
Cdd:COG1196  475 LEAALAELLEELAEAAARLLLLLEAEADYE-----GFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAA-L 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1629 SEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQS 1708
Cdd:COG1196  549 QNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLV 628

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1709 LTENLTKEHLM--LEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEK 1786
Cdd:COG1196  629 AARLEAALRRAvtLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1787 FQKQALEASNRIQESKNQCTQVVQERESLLVKIkvLEQDKARLQRLEDELNRAKSTLEAETRVKqRLeceKQQIQN---- 1862
Cdd:COG1196  709 LAEAEEERLEEELEEEALEEQLEAEREELLEEL--LEEEELLEEEALEELPEPPDLEELERELE-RL---EREIEAlgpv 782

                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813  1863 ------DLNQWKTQY----SRKEEairkiesereksereknsLRSEIERLQAEIKRIEERCRRKLED 1919
Cdd:COG1196  783 nllaieEYEELEERYdflsEQRED------------------LEEARETLEEAIEEIDRETRERFLE 831
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1523-1854 1.64e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 93.46  E-value: 1.64e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1523 ETINKLKVQEQELTRLRI--------------------DYERVSQERTVKDQDITRFQnsLKELQLQKQKVEEELNRLKR 1582
Cdd:COG1196  176 EAERKLEATEENLERLEDilgelerqleplerqaekaeRYRELKEELKELEAELLLLK--LRELEAELEELEAELEELEA 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1583 TASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVE 1662
Cdd:COG1196  254 ELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELE 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1663 ALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEyddlrrgrsead 1742
Cdd:COG1196  334 ELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ------------ 401

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1743 sdknatILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKnqcTQVVQERESLLVKIKVL 1822
Cdd:COG1196  402 ------LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE---EEEEALLELLAELLEEA 472

                        330       340       350
                 ....*....|....*....|....*....|..
gi 1147813  1823 EQDKARLQRLEDELNRAKSTLEAETRVKQRLE 1854
Cdd:COG1196  473 ALLEAALAELLEELAEAAARLLLLLEAEADYE 504
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1018-1627 2.69e-18

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 92.39  E-value: 2.69e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1018 SEMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFL------DQNLQKYQAECSQFKAKLASLEELKRQAELDG 1090
Cdd:TIGR04523  103 SDLSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLteikkkEKELEKLNNKYNDLKKQKEELENELNLLEKEK 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1091 KSAKQNLDKCYGQ----------IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES 1160
Cdd:TIGR04523  183 LNIQKNIDKIKNKllklelllsnLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1161 EKAIK---EKEYEIERLRVLLqeegtrkreyeNELAKVRNHYNEEMSNLRNKYETEINitkTTIKEISMQKEDDSKNLRN 1237
Cdd:TIGR04523  263 NKIKKqlsEKQKELEQNNKKI-----------KELEKQLNQLKSEISDLNNQKEQDWN---KELKSELKNQEKKLEEIQN 328

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1238 QLDRLSRENRDLKDEIVRL----NDSILQATEQRRRAEENALQQKACGSEIMQKKQHLE------IELKQVMQQRSEDNA 1307
Cdd:TIGR04523  329 QISQNNKIISQLNEQISQLkkelTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKnlesqiNDLESKIQNQEKLNQ 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1308 RHKQSLEEAAKTIQDKNKEIERLKAEF---QEEAKRRWEYENELSKVRNNYDEEIISLKNQ---FETEINITKTTIHQLT 1381
Cdd:TIGR04523  409 QKDEQIKKLQQEKELLEKEIERLKETIiknNSEIKDLTNQDSVKELIIKNLDNTRESLETQlkvLSRSINKIKQNLEQKQ 488

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1382 MQKEEDTSgyraQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKatgSEVSQRKQQLEvelrqvtqmrTEE 1461
Cdd:TIGR04523  489 KELKSKEK----ELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKE---SKISDLEDELN----------KDD 551

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1462 SVRYKQSLDdaaKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLkvqEQELTRLRID 1541
Cdd:TIGR04523  552 FELKKENLE---KEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSL---EKELEKAKKE 625

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1542 YERVSQErtvkdqdITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRK----KLEEELEGMRRSLKEQAI----KIT 1613
Cdd:TIGR04523  626 NEKLSSI-------IKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKesktKIDDIIELMKDWLKELSLhykkYIT 698

                          650
                   ....*....|....
gi 1147813    1614 NLTQQLEQASIVKK 1627
Cdd:TIGR04523  699 RMIRIKDLPKLEEK 712
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1161-1912 7.03e-18

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 91.33  E-value: 7.03e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1161 EKAIKEKEYEIERLRVLLQEEgtrkreyeNELAKVRNHY-NEEMSNLRNKYEtEINITKTTIKEISMQKEDDSKNLRNQL 1239
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNES--------NELHEKQKFYlRQSVIDLQTKLQ-EMQMERDAMADIRRRESQSQEDLRNQL 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1240 DRLSRE---NRDLKDEIvrLNDSILQATEQRRR--AEENALQqkacgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
Cdd:pfam15921  148 QNTVHEleaAKCLKEDM--LEDSNTQIEQLRKMmlSHEGVLQ------EIRSILVDFEEASGKKIYEHDSMSTMHFRSLG 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1315 EA-AKTIQDKNKEIERLKA-----EFQEEAKRRwEYENELSKVRNNYDEEIISLKNQFETEInitkTTIHQLTMQKEEDT 1388
Cdd:pfam15921  220 SAiSKILRELDTEISYLKGrifpvEDQLEALKS-ESQNKIELLLQQHQDRIEQLISEHEVEI----TGLTEKASSARSQA 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1389 SGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRrvEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQS 1468
Cdd:pfam15921  295 NSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLR--SELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQES 372

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1469 --LDDA-AKTIQDKNK-------EIERLKQLIDKETND-------RKCLEDENARLQRVQYDLQKANSsatETINKLKVQ 1531
Cdd:pfam15921  373 gnLDDQlQKLLADLHKrekelslEKEQNKRLWDRDTGNsitidhlRRELDDRNMEVQRLEALLKAMKS---ECQGQMERQ 449

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1532 EQELTRLRIDYERVSQertvkdqdITRFQNSLKELQlqkQKVEEELNRLKRTASEDSCKRKKLEEELEGmrrslKEQAIK 1611
Cdd:pfam15921  450 MAAIQGKNESLEKVSS--------LTAQLESTKEML---RKVVEELTAKKMTLESSERTVSDLTASLQE-----KERAIE 513

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1612 ITNltqqleqASIVKKRSEDDLRQQRdvldghLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED 1691
Cdd:pfam15921  514 ATN-------AEITKLRSRVDLKLQE------LQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQ 580

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1692 KSRSlnESKIEIERLQsltenltkehlmLEEELRNLRLEYDDLRRGRSEADS-----DKNATILELRsQLQISNNRTLEL 1766
Cdd:pfam15921  581 HGRT--AGAMQVEKAQ------------LEKEINDRRLELQEFKILKDKKDAkirelEARVSDLELE-KVKLVNAGSERL 645

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1767 QGlINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVleQDKARLQRLEDELNRAKSTLEAE 1846
Cdd:pfam15921  646 RA-VKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKM--QLKSAQSELEQTRNTLKSMEGSD 722

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1847 TRVKQRLECEKQQI-----QNDLNQWKTQY-------SRKE-----EAIRKIESEREKSEREKNSLRSEIERLQAEIKRI 1909
Cdd:pfam15921  723 GHAMKVAMGMQKQItakrgQIDALQSKIQFleeamtnANKEkhflkEEKNKLSQELSTVATEKNKMAGELEVLRSQERRL 802


                   ...
gi 1147813    1910 EER 1912
Cdd:pfam15921  803 KEK 805
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1192-1881 1.12e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 90.08  E-value: 1.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1192 LAKVRNHYNEEMSNLRNKYETEINITKTTIKEI---SMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRR 1268
Cdd:TIGR04523   27 IANKQDTEEKQLEKKLKTIKNELKNKEKELKNLdknLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLS 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1269 RAEENALQQKacgseimQKKQHLEIELKQVMQQRSEDNARHKQSLEEaaktIQDKNKEIERLKAEFQEEAKRRWEYENEL 1348
Cdd:TIGR04523  107 KINSEIKNDK-------EQKNKLEVELNKLEKQKKENKKNIDKFLTE----IKKKEKELEKLNNKYNDLKKQKEELENEL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1349 SKVRNNydeeiislKNQFETEINITKttiHQLTmQKEEDTSgyraQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEE 1428
Cdd:TIGR04523  176 NLLEKE--------KLNIQKNIDKIK---NKLL-KLELLLS----NLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQ 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1429 DIQQQKATGSEVSQRKQQLevelrqvtqmrteesvryKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQ 1508
Cdd:TIGR04523  240 EINEKTTEISNTQTQLNQL------------------KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLN 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1509 RvqydlQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNrlkrtasEDS 1588
Cdd:TIGR04523  302 N-----QKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELE-------EKQ 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1589 CKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRdvldghlREKQRTQEELRRLSSEVEALRRQL 1668
Cdd:TIGR04523  370 NEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQ-------QEKELLEKEIERLKETIIKNNSEI 442

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1669 --LQEQESVKQAHLRN-----EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLrrgrsea 1741
Cdd:TIGR04523  443 kdLTNQDSVKELIIKNldntrESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDL------- 515

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1742 dsdkNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEI--EKFQKQALEASNRIQESKNQCTQVVQERESLLVKI 1819
Cdd:TIGR04523  516 ----TKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELkkENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELI 591

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1147813    1820 KVLEQDKARLQRLEDELNRAKSTLEAETRV----KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKI 1881
Cdd:TIGR04523  592 DQKEKEKKDLIKEIEEKEKKISSLEKELEKakkeNEKLSSIIKNIKSKKNKLKQEVKQIKETIKEI 657
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1022-1700 1.15e-17

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 90.17  E-value: 1.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1022 KSLEDLKLKNTKIEV-LEEELRLARDANSENcNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDgksAKQNLDKC 1100
Cdd:pfam05483  120 KAIQELQFENEKVSLkLEEEIQENKDLIKEN-NATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMD---LNNNIEKM 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1101 YGQIKELNEKIT----RLTYEIEDEKRRRKSVEDRFDQQKNDYDQ---LQKARQCEKEN----LGWQKLESEKAIKEKEY 1169
Cdd:pfam05483  196 ILAFEELRVQAEnarlEMHFKLKEDHEKIQHLEEEYKKEINDKEKqvsLLLIQITEKENkmkdLTFLLEESRDKANQLEE 275

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1170 EIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNlRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDL 1249
Cdd:pfam05483  276 KTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMST-QKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEF 354

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1250 KDEIVRLNDsiLQATEQRRrAEENALQQKACGSEIMQKKQHLEiELKQVMQQRSEDNARHKQSLEEAaKTIQDKNKEIER 1329
Cdd:pfam05483  355 EATTCSLEE--LLRTEQQR-LEKNEDQLKIITMELQKKSSELE-EMTKFKNNKEVELEELKKILAED-EKLLDEKKQFEK 429

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1330 LKAEFQEEakrrweyENELSKVRNNYDEEIISLknqfETEINITKTTIHQLTMQKEE----------DTSGYRAQIDNLT 1399
Cdd:pfam05483  430 IAEELKGK-------EQELIFLLQAREKEIHDL----EIQLTAIKTSEEHYLKEVEDlktelekeklKNIELTAHCDKLL 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1400 RENRSLSEEIKRLKNTLTQTTE---NLRRVEEDIQQQKATGSEV-SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT 1475
Cdd:pfam05483  499 LENKELTQEASDMTLELKKHQEdiiNCKKQEERMLKQIENLEEKeMNLRDELESVREEFIQKGDEVKCKLDKSEENARSI 578

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1476 IQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERtvkDQD 1555
Cdd:pfam05483  579 EYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKF---EEI 655

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1556 ITRFQNSLKELQLQKQKVEEELNRLKRTASEDSckrkKLEEELEgmrrslKEQAIKITNLTQQLEQasivKKRSEDDLRQ 1635
Cdd:pfam05483  656 IDNYQKEIEDKKISEEKLLEEVEKAKAIADEAV----KLQKEID------KRCQHKIAEMVALMEK----HKHQYDKIIE 721

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1147813    1636 QRDVLDGHLREKQRTQEELR-RLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESK 1700
Cdd:pfam05483  722 ERDSELGLYKNKEQEQSSAKaALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKDKK 787
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1353-1944 1.25e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 90.08  E-value: 1.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1353 NNYDEEIISLKNQFETEINITKTtIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQ 1432
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNKEKELKN-LDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKN 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1433 QKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKtiqdKNKEIERLKQLIDKETNDRKCLEDENARLQRVQY 1512
Cdd:TIGR04523  115 DKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEK----LNNKYNDLKKQKEELENELNLLEKEKLNIQKNID 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1513 DLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRtasedscKRK 1592
Cdd:TIGR04523  191 KIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKD-------EQN 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1593 KLEEELEGMRRSLKEQAIKITNLTQQLEQasiVKKRSEDDLRQQRDVLDGHLREKQRTQEElrrlssEVEALRRQLLQEQ 1672
Cdd:TIGR04523  264 KIKKQLSEKQKELEQNNKKIKELEKQLNQ---LKSEISDLNNQKEQDWNKELKSELKNQEK------KLEEIQNQISQNN 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1673 ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEyddlrrgrseadsdknatILEL 1752
Cdd:TIGR04523  335 KIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQ------------------INDL 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1753 RSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQdkaRLQRL 1832
Cdd:TIGR04523  397 ESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLET---QLKVL 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1833 EDELNRAKSTLEAETRvkqrlecEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1912
Cdd:TIGR04523  474 SRSINKIKQNLEQKQK-------ELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDE 546

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1147813    1913 crrKLEDSTRETQSQLETERSRYQREIDKLRQ 1944
Cdd:TIGR04523  547 ---LNKDDFELKKENLEKEIDEKNKEIEELKQ 575
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1644-1946 1.97e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 89.61  E-value: 1.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1644 LREKQRTQEELRRLS---SEVE------------ALRRQLLQEQESVKQAHLRnehfQKAIEDKSRSLNESKIEIERLQS 1708
Cdd:COG1196  178 ERKLEATEENLERLEdilGELErqleplerqaekAERYRELKEELKELEAELL----LLKLRELEAELEELEAELEELEA 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1709 LTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD---KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIE 1785
Cdd:COG1196  254 ELEELEAELAELEAELEELRLELEELELELEEAQAEeyeLLAELARLEQDIARLEERRRELEERLEELEEELAELEEELE 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1786 KFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLEcekQQIQNDLN 1865
Cdd:COG1196  334 ELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQL---EELEEAEE 410

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1866 QWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:COG1196  411 ALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAA 490


                 .
gi 1147813  1946 P 1946
Cdd:COG1196  491 A 491
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1313-1942 7.71e-17

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 87.81  E-value: 7.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1313 LEEAAKTIQDKNKEIERLKAEFQEEAKRrweyenelskvrnnyDEEIISLKNQFETEINITKTTIHQLtMQKEEDTSGYR 1392
Cdd:PRK03918  160 YENAYKNLGEVIKEIKRRIERLEKFIKR---------------TENIEELIKEKEKELEEVLREINEI-SSELPELREEL 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1393 AQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMR--TEESVRYKQSLD 1470
Cdd:PRK03918  224 EKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKekAEEYIKLSEFYE 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1471 DAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQrvqyDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERT 1550
Cdd:PRK03918  304 EYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLE----ELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKK 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1551 -VKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQlEQASIVKKRS 1629
Cdd:PRK03918  380 rLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEE-HRKELLEEYT 458

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1630 EDdlrqqrdvLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEhfQKAIEDKSRSLNesKIEIERLQSL 1709
Cdd:PRK03918  459 AE--------LKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQ--LKELEEKLKKYN--LEELEKKAEE 526

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1710 TENLTKEHLMLEEELRNLRleyDDLRRgrseadsdknatilelrsqLQISNNRTLELQGLINDLQRERENLRQEIEKFQK 1789
Cdd:PRK03918  527 YEKLKEKLIKLKGEIKSLK---KELEK-------------------LEELKKKLAELEKKLDELEEELAELLKELEELGF 584

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1790 QALEASNRiqesknqctqVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKT 1869
Cdd:PRK03918  585 ESVEELEE----------RLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEK 654

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1147813   1870 QYSrkEEAIRKIESEREksereknSLRSEIERLQAEIKRIEERcRRKLEDSTRETQSQLEtERSRYQREIDKL 1942
Cdd:PRK03918  655 KYS--EEEYEELREEYL-------ELSRELAGLRAELEELEKR-REEIKKTLEKLKEELE-EREKAKKELEKL 716
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1266-1943 1.29e-16

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 87.10  E-value: 1.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1266 QRRRAEENALQQKAcGSEIMQKKQHLEIELKQVMQQR---SEDNARHKQSLEEAAKTIQDKNKEIER---LKAEFQEEAK 1339
Cdd:pfam15921   91 QRRLNESNELHEKQ-KFYLRQSVIDLQTKLQEMQMERdamADIRRRESQSQEDLRNQLQNTVHELEAakcLKEDMLEDSN 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1340 RRWEYENELSKVRNNYDEEIISLKNQFEteiNITKTTIHQltmQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQt 1419
Cdd:pfam15921  170 TQIEQLRKMMLSHEGVLQEIRSILVDFE---EASGKKIYE---HDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFP- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1420 tenlrrVEEDIQQQKATgsevSQRKQQLEVELRQ--VTQMRTEESVRYKqSLDDAAKTIQDKNKEIERLKQLIDKETNDR 1497
Cdd:pfam15921  243 ------VEDQLEALKSE----SQNKIELLLQQHQdrIEQLISEHEVEIT-GLTEKASSARSQANSIQSQLEIIQEQARNQ 311

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1498 KC-----LEDENARLQRVQYDLQKANSSATETINKLKVQ----EQELTRLRIDYERVSQERTVKDQditRFQNSLKELQL 1568
Cdd:pfam15921  312 NSmymrqLSDLESTVSQLRSELREAKRMYEDKIEELEKQlvlaNSELTEARTERDQFSQESGNLDD---QLQKLLADLHK 388

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1569 QKQKVEEELNRLKRTASEDSCKRKKLEEelegMRRSLKEQAIKITNLTQQLEQasiVKKRSEDDLRQQRDVLDGhlreKQ 1648
Cdd:pfam15921  389 REKELSLEKEQNKRLWDRDTGNSITIDH----LRRELDDRNMEVQRLEALLKA---MKSECQGQMERQMAAIQG----KN 457

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1649 RTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLR 1728
Cdd:pfam15921  458 ESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLK 537

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1729 LEYDDLRRGRSEADSDKnatilelrsqLQISnnrtlELQGLINDLQRERENLRQEIEKFQKQAleasNRIQESKNQCTQV 1808
Cdd:pfam15921  538 NEGDHLRNVQTECEALK----------LQMA-----EKDKVIEILRQQIENMTQLVGQHGRTA----GAMQVEKAQLEKE 598

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1809 VQERESLLVKIKVLEQDKARLQRledelnrakstlEAETRVKQrLECEKQQIQNdlnqwktQYSRKEEAIRKIESEREKS 1888
Cdd:pfam15921  599 INDRRLELQEFKILKDKKDAKIR------------ELEARVSD-LELEKVKLVN-------AGSERLRAVKDIKQERDQL 658

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813    1889 EREKNSLRSEIERLQAEIKRIEERCRRK---LEDSTRETQSQLETERSRYQREIDKLR 1943
Cdd:pfam15921  659 LNEVKTSRNELNSLSEDYEVLKRNFRNKseeMETTTNKLKMQLKSAQSELEQTRNTLK 716
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1038-1880 2.27e-16

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 86.38  E-value: 2.27e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1038 EEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAEldgksakQNLDKCYGQIKELNEKITRLTYE 1117
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAE-------EMRARLAARKQELEEILHELESR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1118 IEDEkrrrksvEDRFDQQKNDYDQLQK-----ARQCEKENLGWQKLESEKAIKE-KEYEIERLRVLLQEEGTR----KRE 1187
Cdd:pfam01576   84 LEEE-------EERSQQLQNEKKKMQQhiqdlEEQLDEEEAARQKLQLEKVTTEaKIKKLEEDILLLEDQNSKlskeRKL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1188 YENELAKVRNHYNEE------MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRnqldRLSRENRDLKDEIVRLNDSIL 1261
Cdd:pfam01576  157 LEERISEFTSNLAEEeekaksLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKR----KLEGESTDLQEQIAELQAQIA 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1262 QATEQRRRAEEnalqqkacgseimqkkqhleiELkQVMQQRSEDNARHKQSLeeaaktiQDKNKEIERLKAEFQEEAKRR 1341
Cdd:pfam01576  233 ELRAQLAKKEE---------------------EL-QAALARLEEETAQKNNA-------LKKIRELEAQISELQEDLESE 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTtihqltmQKEedtsgYRAQidnltREnrslsEEIKRLKNTLtqtte 1421
Cdd:pfam01576  284 RAARNKAEKQRRDLGEELEALKTELEDTLDTTAA-------QQE-----LRSK-----RE-----QEVTELKKAL----- 336

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1422 nlrrvEEDIQQQKATGSEVSQRKQQLEVELrqvtQMRTEESVRYKQSLDDAAKTIQDKNKEI-ERLKQLIDKETndrkcl 1500
Cdd:pfam01576  337 -----EEETRSHEAQLQEMRQKHTQALEEL----TEQLEQAKRNKANLEKAKQALESENAELqAELRTLQQAKQ------ 401

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1501 eDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRL 1580
Cdd:pfam01576  402 -DSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEE 480

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1581 KRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGhlrekqrTQEELRRLSSE 1660
Cdd:pfam01576  481 TRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEA-------LEEGKKRLQRE 553

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1661 VEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSrslneskIEIERLQSLTENLTKEH----LMLEEElRNLRLEYDDlRR 1736
Cdd:pfam01576  554 LEALTQQLEEKAAAYDKLEKTKNRLQQELDDLL-------VDLDHQRQLVSNLEKKQkkfdQMLAEE-KAISARYAE-ER 624

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1737 GRSEADS-DKNATILELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKfqkqaleasnrIQESKNQCTQVVQERE-S 1814
Cdd:pfam01576  625 DRAEAEArEKETRALSLARALE-------EALEAKEELERTNKQLRAEMED-----------LVSSKDDVGKNVHELErS 686

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1147813    1815 LLVKIKVLEQDKARLQRLEDELnraKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRK 1880
Cdd:pfam01576  687 KRALEQQVEEMKTQLEELEDEL---QATEDAKLRLEVNMQALKAQFERDLQARDEQGEEKRRQLVK 749
PTZ00121 PTZ00121
MAEBL; Provisional
 1168-2031 2.98e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 86.35  E-value: 2.98e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1168 EYEIERLRVLLQEEGTRKREYENEL-AKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNlrnqldrlsren 1246
Cdd:PTZ00121 1057 EGKAEAKAHVGQDEGLKPSYKDFDFdAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKA------------ 1124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1247 rdlkdEIVRLNDSILQAtEQRRRAEENALQQKACGSEIMQKKQhleiELKQVMQQRSEDNARHkqsLEEAAKTIQ-DKNK 1325
Cdd:PTZ00121 1125 -----EDARKAEEARKA-EDARKAEEARKAEDAKRVEIARKAE----DARKAEEARKAEDAKK---AEAARKAEEvRKAE 1191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1326 EIERLKAEFQEEAKRRWEYENELSKVRNNYDEEII-SLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRS 1404
Cdd:PTZ00121 1192 ELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAeAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAA 1271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1405 LSEEIKRlkntltqTTENLRRVEEDIQQQKATGSEVSQRKQQLevelrqvtQMRTEEsvryKQSLDDAAKTIQDKNKEIE 1484
Cdd:PTZ00121 1272 IKAEEAR-------KADELKKAEEKKKADEAKKAEEKKKADEA--------KKKAEE----AKKADEAKKKAEEAKKKAD 1332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1485 RLKQlidKETNDRKCLEDENARLQRVQYDLQKANSSATEtiNKLKVQEQ----ELTRLRIDYERVSQERTVKDQDITRFQ 1560
Cdd:PTZ00121 1333 AAKK---KAEEAKKAAEAAKAEAEAAADEAEAAEEKAEA--AEKKKEEAkkkaDAAKKKAEEKKKADEAKKKAEEDKKKA 1407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQ---ASIVKKRSEDdlRQQR 1637
Cdd:PTZ00121 1408 DELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEakkADEAKKKAEE--AKKA 1485

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1638 DVLDGHLREKQRTQEELRRlSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIE----IERLQSLTENL 1713
Cdd:PTZ00121 1486 DEAKKKAEEAKKKADEAKK-AAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADelkkAEELKKAEEKK 1564

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1714 TKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALE 1793
Cdd:PTZ00121 1565 KAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE 1644

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1794 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNqwKTQYSR 1873
Cdd:PTZ00121 1645 EKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK--KAEELK 1722

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1874 KEEAIRKIE--SEREKsereknslrSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDK-LRQRPYGSH 1950
Cdd:PTZ00121 1723 KAEEENKIKaeEAKKE---------AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEeLDEEDEKRR 1793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1951 RETQTECEWTVDTSKLVFDGLRKKVTAMQlyECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASA-----SP 2025
Cdd:PTZ00121 1794 MEVDKKIKDIFDNFANIIEGGKEGNLVIN--DSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGnkeadFN 1871


                  ....*.
gi 1147813   2026 KEKYSL 2031
Cdd:PTZ00121 1872 KEKDLK 1877
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1094-1778 3.02e-16

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 85.94  E-value: 3.02e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1094 KQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD---QQKNDYDQLQKARQCEKEN----LGWQKLESEKAIKE 1166
Cdd:pfam15921  263 QQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEiiqEQARNQNSMYMRQLSDLEStvsqLRSELREAKRMYED 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1167 KEYEIERLRVLLQEEGTRKREYenelakvRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSK----NLRNQL--D 1240
Cdd:pfam15921  343 KIEELEKQLVLANSELTEARTE-------RDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRlwdrDTGNSItiD 415

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1241 RLSRENRDLKDEIVRLnDSILQA--TEQRRRAEEN--ALQQKacgSEIMQKKQHLEIEL---KQVMQQRSEDNARHKQSL 1313
Cdd:pfam15921  416 HLRRELDDRNMEVQRL-EALLKAmkSECQGQMERQmaAIQGK---NESLEKVSSLTAQLestKEMLRKVVEELTAKKMTL 491

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1314 EEAAKTIQDknkeierLKAEFQEEAKRRWEYENELSKVRNNYD---EEIISLKNQFETEINItKTTIHQLTMQ---KEED 1387
Cdd:pfam15921  492 ESSERTVSD-------LTASLQEKERAIEATNAEITKLRSRVDlklQELQHLKNEGDHLRNV-QTECEALKLQmaeKDKV 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1388 TSGYRAQIDNLT-------RENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTE 1460
Cdd:pfam15921  564 IEILRQQIENMTqlvgqhgRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSE 643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1461 E--SVR-YKQSLDDAAKTIQDKNKEIERLKQliDKET---NDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQE 1534
Cdd:pfam15921  644 RlrAVKdIKQERDQLLNEVKTSRNELNSLSE--DYEVlkrNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGS 721

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1535 LTRLRIDYERVSQERTVKDQDITRFQNSLKELQ-------LQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMR---RS 1604
Cdd:pfam15921  722 DGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEeamtnanKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRsqeRR 801

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1605 LKEqaiKITNLTQQLEQASIVKKRSEDDLRQQrdvldghlrEKQRTQEELRRlSSEVEALRRQLLQEQESVKQAHLRNEH 1684
Cdd:pfam15921  802 LKE---KVANMEVALDKASLQFAECQDIIQRQ---------EQESVRLKLQH-TLDVKELQGPGYTSNSSMKPRLLQPAS 868

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1685 FQKAIEDKSRSLNESKI---EIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADS------------DKNATI 1749
Cdd:pfam15921  869 FTRTHSNVPSSQSTASFlshHSRKTNALKEDPTRDLKQLLQELRSVINEEPTVQLSKAEDKGrapslgalddrvRDCIIE 948

                          730       740
                   ....*....|....*....|....*....
gi 1147813    1750 LELRSQLQISNNRTLELQGLINDLQRERE 1778
Cdd:pfam15921  949 SSLRSDICHSSSNSLQTEGSKSSETCSRE 977
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1032-1687 3.19e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 85.76  E-value: 3.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1032 TKIEVLEEELRLARDansencnknKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
Cdd:COG1196  220 EELKELEAELLLLKL---------RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEE 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1112 TRLTYEIEDEKRRRKSVEDRfdqqkndydqlQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENE 1191
Cdd:COG1196  291 YELLAELARLEQDIARLEER-----------RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1192 LAKVRNHYNEEMSNLRnkyetEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAE 1271
Cdd:COG1196  360 LAEAEEALLEAEAELA-----EAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1272 ENALQQKacgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
Cdd:COG1196  435 EEEEEEE----EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGV 510

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1352 RNnydEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIdnLTRENRSLSEEIKRLKNTL--TQTTENLRRVEED 1429
Cdd:COG1196  511 KA---ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNI--VVEDDEVAAAAIEYLKAAKagRATFLPLDKIRAR 585

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1430 IQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRkclEDENARLQR 1509
Cdd:COG1196  586 AALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEG---EGGSAGGSL 662

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1510 VQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSC 1589
Cdd:COG1196  663 TGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELL 742

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1590 KRKKLEEELEGMRR----SLKEQAIKITNLTQQLEQ------ASI-----VKKRsEDDLRQQRDVLdghlrekQRTQEEL 1654
Cdd:COG1196  743 EEEELLEEEALEELpeppDLEELERELERLEREIEAlgpvnlLAIeeyeeLEER-YDFLSEQREDL-------EEARETL 814

                        650       660       670
                 ....*....|....*....|....*....|....
gi 1147813  1655 RRLSSEVEALRRQLLQEQ-ESVkqahlrNEHFQK 1687
Cdd:COG1196  815 EEAIEEIDRETRERFLETfDAV------NENFQE 842
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1002-1790 3.50e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 85.89  E-value: 3.50e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1002 RYIELLTRSGDY--YRFLSEMLKSLEDLKLKNTKIEVLEEEL---------------RLARDANSENCNKNKFLDQNLQK 1064
Cdd:TIGR02169  212 RYQALLKEKREYegYELLKEKEALERQKEAIERQLASLEEELeklteeiselekrleEIEQLLEELNKKIKDLGEEEQLR 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL-Q 1143
Cdd:TIGR02169  292 VKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLrA 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1144 KARQCEKENLGW-QKLESEK----AIKEKEYEIERLRVLLQEEGTRKREyenELAKVRNhyneEMSNLRNKYETEINITK 1218
Cdd:TIGR02169  372 ELEEVDKEFAETrDELKDYRekleKLKREINELKRELDRLQEELQRLSE---ELADLNA----AIAGIEAKINELEEEKE 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1219 TTIKEISmQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEEnalQQKACGSEIMQKKQhLEIELKQV 1298
Cdd:TIGR02169  445 DKALEIK-KQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEA---QARASEERVRGGRA-VEEVLKAS 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1299 MQ-------QRSEDNARHKQSLEEAA---------KTIQDKNKEIERLK------AEFQEEAKRRwEYENELSKVRNN-- 1354
Cdd:TIGR02169  520 IQgvhgtvaQLGSVGERYATAIEVAAgnrlnnvvvEDDAVAKEAIELLKrrkagrATFLPLNKMR-DERRDLSILSEDgv 598

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1355 --YDEEIISLKNQFEteiNITKTTIHQ-LTMQKEEDTSGYRAQIDNLTrenrsLSEEIKRLKNTLTQTTENLRRVEEDIQ 1431
Cdd:TIGR02169  599 igFAVDLVEFDPKYE---PAFKYVFGDtLVVEDIEAARRLMGKYRMVT-----LEGELFEKSGAMTGGSRAPRGGILFSR 670

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1432 QQKATGSEVSQRKQQLEVELRQVTQMRTE---ESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET-------NDRKCLE 1501
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRienRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKerleeleEDLSSLE 750

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1502 DENARLQRVQYDLQKANSSATETINKLKVQEQELTRlRIDYERV--------SQERTVKDQD--ITRFQNSLKELQLQKQ 1571
Cdd:TIGR02169  751 QEIENVKSELKELEARIEELEEDLHKLEEALNDLEA-RLSHSRIpeiqaelsKLEEEVSRIEarLREIEQKLNRLTLEKE 829

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1572 KVEEELNRLKRTASEDSCKRKKLE---EELEGMRRSLKEQAIKITNLTQQLEqasivKKRSedDLRQQRDVLDGHLREKQ 1648
Cdd:TIGR02169  830 YLEKEIQELQEQRIDLKEQIKSIEkeiENLNGKKEELEEELEELEAALRDLE-----SRLG--DLKKERDELEAQLRELE 902

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1649 RTQEElrrLSSEVEALRRQLLQEQESVKQAHLRNehfqKAIEDKSRSLNESKIEIERLQSLTENLTKehlmLEEELRNLr 1728
Cdd:TIGR02169  903 RKIEE---LEAQIEKKRKRLSELKAKLEALEEEL----SEIEDPKGEDEEIPEEELSLEDVQAELQR----VEEEIRAL- 970

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813    1729 leyddlrrgrseaDSDKNATILELRSQLQisnnRTLELQGLINDLQRERENLRQEIEKFQKQ 1790
Cdd:TIGR02169  971 -------------EPVNMLAIQEYEEVLK----RLDELKEKRAKLEEERKAILERIEEYEKK 1015
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1026-1798 5.39e-16

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 85.10  E-value: 5.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1026 DLKLKNTKIEVLEEELRLARDANsENCNKnkfLDQNLQKYQAECSQFKAKLASLeelKRQAELDGKSAKQNLDKCYGQIK 1105
Cdd:TIGR00606  389 ERQIKNFHTLVIERQEDEAKTAA-QLCAD---LQSKERLKQEQADEIRDEKKGL---GRTIELKKEILEKKQEELKFVIK 461

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEE 1181
Cdd:TIGR00606  462 ELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLKKEvkslQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLT 541

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1182 GTRKREYEnELAKVRNHYNEEMSNLRNKYETEINITKTTIKeismqKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSIL 1261
Cdd:TIGR00606  542 KDKMDKDE-QIRKIKSRHSDELTSLLGYFPNKKQLEDWLHS-----KSKEINQTRDRLAKLNKELASLEQNKNHINNELE 615

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1262 QATEQRRRAEENALQqkACGSEIMQKK-QHLEIELKQVMQQR---SEDNARHKQSLEEAAKTIQDKNKEIERL---KAEF 1334
Cdd:TIGR00606  616 SKEEQLSSYEDKLFD--VCGSQDEESDlERLKEEIEKSSKQRamlAGATAVYSQFITQLTDENQSCCPVCQRVfqtEAEL 693

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1335 QEEAKrrwEYENELSKVRNNYDE-EIISLKNQFETEINITKTTIHQLTMQKEEDtsgyraQIDNLTRENRSLSEEIKRLK 1413
Cdd:TIGR00606  694 QEFIS---DLQSKLRLAPDKLKStESELKKKEKRRDEMLGLAPGRQSIIDLKEK------EIPELRNKLQKVNRDIQRLK 764

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1414 NTLTQTTENLRRVEEDIQQQKATGSEVSQrKQQLEVELRQVtQMRTEESVRYKQSLDdAAKTIQDKNKEIE----RLKQL 1489
Cdd:TIGR00606  765 NDIEEQETLLGTIMPEEESAKVCLTDVTI-MERFQMELKDV-ERKIAQQAAKLQGSD-LDRTVQQVNQEKQekqhELDTV 841

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1490 IDKETNDRKCLEDENARLQRVQY--------------DLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQD 1555
Cdd:TIGR00606  842 VSKIELNRKLIQDQQEQIQHLKSktnelkseklqigtNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKD 921

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1556 ITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL-EGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLR 1634
Cdd:TIGR00606  922 QQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIqDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMR 1001

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1635 QQRDVLDG-HLREK----QRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSL 1709
Cdd:TIGR00606 1002 LMRQDIDTqKIQERwlqdNLTLRKRENELKEVEEELKQHLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYE 1081

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1710 TENLTKEHLMLEEELRNLRLEYDDLrrgrseadsdknatILELRSQLQIsnnrtlelqglINDLQRERENLRQEIEKFQK 1789
Cdd:TIGR00606 1082 KEIKHFKKELREPQFRDAEEKYREM--------------MIVMRTTELV-----------NKDLDIYYKTLDQAIMKFHS 1136


                   ....*....
gi 1147813    1790 QALEASNRI 1798
Cdd:TIGR00606 1137 MKMEEINKI 1145
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1148-1930 6.43e-16

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 85.10  E-value: 6.43e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1148 CEKENLGWqKLESEKAIKEKEYEI----------ERLRVLLQEEGTRKREYENELaKVRNHYNEEMSNLRNKYETEINiT 1217
Cdd:TIGR00606  156 CHQEDSNW-PLSEGKALKQKFDEIfsatryikalETLRQVRQTQGQKVQEHQMEL-KYLKQYKEKACEIRDQITSKEA-Q 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1218 KTTIKEISMQKEDDSKNLRNQLdrlsRENRDLKDEIVRLNDSI--LQATEQRRRAEENALQQKacgseIMQKKQHLEIEL 1295
Cdd:TIGR00606  233 LESSREIVKSYENELDPLKNRL----KEIEHNLSKIMKLDNEIkaLKSRKKQMEKDNSELELK-----MEKVFQGTDEQL 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1296 KQVMQQrsednarHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVR----------NNYDEEIISLKNQ 1365
Cdd:TIGR00606  304 NDLYHN-------HQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQlqadrhqehiRARDSLIQSLATR 376

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1366 FETE-------INITKTTIHQLTMQKEEDTSGYRAQ---------------IDNLTRENRSLSEEIKRLKNTLTQTTENL 1423
Cdd:TIGR00606  377 LELDgfergpfSERQIKNFHTLVIERQEDEAKTAAQlcadlqskerlkqeqADEIRDEKKGLGRTIELKKEILEKKQEEL 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1424 RRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVrykQSLDDAAKTIQDKNKEIERLKQLIDKETNDRkcleDE 1503
Cdd:TIGR00606  457 KFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLT---ETLKKEVKSLQNEKADLDRKLRKLDQEMEQL----NH 529

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1504 NARLQRVQYDLQKANSSATETINKLKVQ-EQELTRLRIDY----------ERVSQERTVKDQDITRFQNSLKELQLQKQK 1572
Cdd:TIGR00606  530 HTTTRTQMEMLTKDKMDKDEQIRKIKSRhSDELTSLLGYFpnkkqledwlHSKSKEINQTRDRLAKLNKELASLEQNKNH 609

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1573 VEEELNRLKRTASE------DSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLRE 1646
Cdd:TIGR00606  610 INNELESKEEQLSSyedklfDVCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQT 689

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1647 KQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI----ERLQSLTENLTKEHLMLEE 1722
Cdd:TIGR00606  690 EAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIpelrNKLQKVNRDIQRLKNDIEE 769

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1723 ELRNLRLEYDDLRrgrSEADSDKNATILElRSQLQISNN------RTLELQGLinDLQRERENLRQEIEKFQKQALEASN 1796
Cdd:TIGR00606  770 QETLLGTIMPEEE---SAKVCLTDVTIME-RFQMELKDVerkiaqQAAKLQGS--DLDRTVQQVNQEKQEKQHELDTVVS 843

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1797 RIQESKnQCTQVVQERESLLvKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLEC------EKQQIQNDLNQWKTQ 1870
Cdd:TIGR00606  844 KIELNR-KLIQDQQEQIQHL-KSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLireikdAKEQDSPLETFLEKD 921

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1871 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLET 1930
Cdd:TIGR00606  922 QQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNT 981
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1401-1783 1.03e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 84.34  E-value: 1.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1401 ENRSLSEE---IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRteesvRYKQSLDDAAKTI- 1476
Cdd:TIGR02168  156 ERRAIFEEaagISKYKERRKETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYK-----ELKAELRELELALl 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1477 ----QDKNKEIERLKQLIDKETNDRKCLEDEnarlqrvqydLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVK 1552
Cdd:TIGR02168  231 vlrlEELREELEELQEELKEAEEELEELTAE----------LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1553 DQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD 1632
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQ 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1633 LRQQRDVLDGHLREKQRTQEELRRLSSEVEAL---RRQLLQEQESVKQAHLRNEhfqkaIEDKSRSLNESKIEIERLQSL 1709
Cdd:TIGR02168  381 LETLRSKVAQLELQIASLNNEIERLEARLERLedrRERLQQEIEELLKKLEEAE-----LKELQAELEELEEELEELQEE 455

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1147813    1710 TENLTKEHLMLEEELRNLRLEYDDLRRgrseadsdknatilelrsQLQisnnrtlELQGLINDLQRERENLRQE 1783
Cdd:TIGR02168  456 LERLEEALEELREELEEAEQALDAAER------------------ELA-------QLQARLDSLERLQENLEGF 504
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1060-1912 1.28e-15

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 83.94  E-value: 1.28e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1060 QNLQKYQAECSQFKAKLASLEELKrqaelDGKSAKQNLDKCYGQIKELNEKitrltyEIEDEKRRRKSVEDRFDQQKNDY 1139
Cdd:TIGR00606  200 QKVQEHQMELKYLKQYKEKACEIR-----DQITSKEAQLESSREIVKSYEN------ELDPLKNRLKEIEHNLSKIMKLD 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVR------NHYNEEMSNLRNKYETE 1213
Cdd:TIGR00606  269 NEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQreleklNKERRLLNQEKTELLVE 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1214 INITKTTIKEISMQ-----KEDDSKNLRNQLDRLSReNRDLKDEIVRLNDSILQATEQRRR---------AEENALQQKA 1279
Cdd:TIGR00606  349 QGRLQLQADRHQEHirardSLIQSLATRLELDGFER-GPFSERQIKNFHTLVIERQEDEAKtaaqlcadlQSKERLKQEQ 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1280 CgSEIMQKKQHLE--IELKQVMQQRSEDNARHK----QSLEEAAKTIQDKNKEIERLKAEFqEEAKRRWEYENELSKVRN 1353
Cdd:TIGR00606  428 A-DEIRDEKKGLGrtIELKKEILEKKQEELKFVikelQQLEGSSDRILELDQELRKAEREL-SKAEKNSLTETLKKEVKS 505

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1354 NYDEEIISLK-----NQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEI------KRLKNTLTQTTEN 1422
Cdd:TIGR00606  506 LQNEKADLDRklrklDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLgyfpnkKQLEDWLHSKSKE 585

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1423 LRRVEEDIQQQKATGSEVSQRKQQLEVELRQvtqmRTEESVRYKQSLDDAAKTiQDKNKEIERLKQLIDKETNDRKCL-- 1500
Cdd:TIGR00606  586 INQTRDRLAKLNKELASLEQNKNHINNELES----KEEQLSSYEDKLFDVCGS-QDEESDLERLKEEIEKSSKQRAMLag 660

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1501 ------------EDEN--------------ARLQRVQYDLQKANSSATetiNKLKVQEQELTRLRIDYERVSQERTVKDQ 1554
Cdd:TIGR00606  661 atavysqfitqlTDENqsccpvcqrvfqteAELQEFISDLQSKLRLAP---DKLKSTESELKKKEKRRDEMLGLAPGRQS 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1555 DITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEgmrrSLKEQAIKITNLTQQLEQASIVKKRSEdDLR 1634
Cdd:TIGR00606  738 IIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEE----SAKVCLTDVTIMERFQMELKDVERKIA-QQA 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1635 QQRDVLDGHL------REKQRTQEELRRLSSEVEALRRQLLQEQESVKQahlrnehfqkaIEDKSRSLNESKIEIERLQS 1708
Cdd:TIGR00606  813 AKLQGSDLDRtvqqvnQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQH-----------LKSKTNELKSEKLQIGTNLQ 881

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1709 LTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENL---RQEIE 1785
Cdd:TIGR00606  882 RRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIhgyMKDIE 961

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1786 KF-----QKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQD----KARLQRLEDELNRAKSTLEAETRVKQRLECE 1856
Cdd:TIGR00606  962 NKiqdgkDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDidtqKIQERWLQDNLTLRKRENELKEVEEELKQHL 1041

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1147813    1857 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1912
Cdd:TIGR00606 1042 KEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFR 1097
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1394-1942 3.12e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 82.53  E-value: 3.12e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1394 QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEdiqqqkaTGSEVSQRKQQLEvELRQVTQMRTEESVRYKQSLDDAA 1473
Cdd:pfam01576   27 ELKELEKKHQQLCEEKNALQEQLQAETELCAEAEE-------MRARLAARKQELE-EILHELESRLEEEEERSQQLQNEK 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1474 KTIQDKNKEIE---------RLKQLIDKETNDRKC---------LEDENARLQRVQYDLQKANSSATETINKLKVQEQEL 1535
Cdd:pfam01576   99 KKMQQHIQDLEeqldeeeaaRQKLQLEKVTTEAKIkkleedillLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSL 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1536 TRLRIDYERVSQERTVKdqdITRFQNSLKELQLQKQKVEEELN-------RLKRTASEDSCKRKKLEEELEGMRRSLKEQ 1608
Cdd:pfam01576  179 SKLKNKHEAMISDLEER---LKKEEKGRQELEKAKRKLEGESTdlqeqiaELQAQIAELRAQLAKKEEELQAALARLEEE 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1609 AIKITNLTQQLEQASIVKKRSEDDLRQQRDVldghlREKQRTQEelRRLSSEVEALRRQLLQEQESVK-QAHLRN----- 1682
Cdd:pfam01576  256 TAQKNNALKKIRELEAQISELQEDLESERAA-----RNKAEKQR--RDLGEELEALKTELEDTLDTTAaQQELRSkreqe 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1683 -EHFQKAIEDKSRS---------------LNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKN 1746
Cdd:pfam01576  329 vTELKKALEEETRSheaqlqemrqkhtqaLEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRK 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1747 atilELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESL---LVKIKVLE 1823
Cdd:pfam01576  409 ----KLEGQLQ-------ELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLesqLQDTQELL 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1824 QDKAR--------LQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSL 1895
Cdd:pfam01576  478 QEETRqklnlstrLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEAL 557

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1147813    1896 RSEIERLQAEIKRIE---ERCRRKLEDSTRE--TQSQLETERSRYQREIDKL 1942
Cdd:pfam01576  558 TQQLEEKAAAYDKLEktkNRLQQELDDLLVDldHQRQLVSNLEKKQKKFDQM 609
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1211-1874 3.39e-15

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 82.32  E-value: 3.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1211 ETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGsEIMQKKQH 1290
Cdd:TIGR00618  193 HGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLK-QLRARIEE 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1291 LEIELKQVMQQRSEDN-ARHKQSLEEAAKTIQDKNKEIERLKAEFQEEakrrweyENELSKVRNNYdeeiislKNQFETE 1369
Cdd:TIGR00618  272 LRAQEAVLEETQERINrARKAAPLAAHIKAVTQIEQQAQRIHTELQSK-------MRSRAKLLMKR-------AAHVKQQ 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1370 INITKTTIHQLTMQKEEDtsgyraqidnltrENRSLSEEIKRLKNTLTQTTENLRRVEEdIQQQKATGSEVSQ-RKQQLE 1448
Cdd:TIGR00618  338 SSIEEQRRLLQTLHSQEI-------------HIRDAHEVATSIREISCQQHTLTQHIHT-LQQQKTTLTQKLQsLCKELD 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1449 VELRQVTQMRTEESVR--YKQSLDDAAKTIQDKNKEIERLKQLIDKETndrKCLEDENARLQRVQYDL-QKANSSATETI 1525
Cdd:TIGR00618  404 ILQREQATIDTRTSAFrdLQGQLAHAKKQQELQQRYAELCAAAITCTA---QCEKLEKIHLQESAQSLkEREQQLQTKEQ 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1526 NKLKVQEQELTRLRIDYERVSQERTVKDQDI-------------------TRFQNSLKELQLQKQKVEEELNRLKRTASE 1586
Cdd:TIGR00618  481 IHLQETRKKAVVLARLLELQEEPCPLCGSCIhpnparqdidnpgpltrrmQRGEQTYAQLETSEEDVYHQLTSERKQRAS 560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1587 DSCKRKKLEEELEGM---RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQE---ELRRLSSE 1660
Cdd:TIGR00618  561 LKEQMQEIQQSFSILtqcDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDvrlHLQQCSQE 640

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1661 VEALRRQLLQEQESVKQAHLRnEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740
Cdd:TIGR00618  641 LALKLTALHALQLTLTQERVR-EHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDRE 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1741 ADSDKNAtileLRSQLQISNNRTLELQGLINDLQRErenlrqeiekfQKQALEASNRIQESKNQctQVVQErESLLVKIK 1820
Cdd:TIGR00618  720 FNEIENA----SSSLGSDLAAREDALNQSLKELMHQ-----------ARTVLKARTEAHFNNNE--EVTAA-LQTGAELS 781

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813    1821 VLEQDKARLQRLEDELNRAKSTLEAETRVK-----QRLECEKQQIQNDLNQWKTQYSRK 1874
Cdd:TIGR00618  782 HLAAEIQFFNRLREEDTHLLKTLEAEIGQEipsdeDILNLQCETLVQEEEQFLSRLEEK 840
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1649-1985 4.65e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.03  E-value: 4.65e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1649 RTQEELRRLSSEVEALRRQL--LQEQ-ESVKQAH-LRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEEL 1724
Cdd:TIGR02168  183 RTRENLDRLEDILNELERQLksLERQaEKAERYKeLKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAEL 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1725 RNLRLEYDDLRRGRSEADSDKNatilELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
Cdd:TIGR02168  263 QELEEKLEELRLEVSELEEEIE----ELQKELY-------ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1805 ctqvvqeresllvkikvLEQDKARLQRLEDELNRAKSTLEAEtrvKQRLECEKQQIQNDLNQWKTQysrkEEAIRKIESE 1884
Cdd:TIGR02168  332 -----------------LDELAEELAELEEKLEELKEELESL---EAELEELEAELEELESRLEEL----EEQLETLRSK 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1885 REKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQrpygSHRETQTECEWTVDTS 1964
Cdd:TIGR02168  388 VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEE----ELEELQEELERLEEAL 463

                          330       340
                   ....*....|....*....|.
gi 1147813    1965 KLVFDGLRKKVTAMQLYECQL 1985
Cdd:TIGR02168  464 EELREELEEAEQALDAAEREL 484
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1072-1671 5.49e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 81.65  E-value: 5.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1072 FKAKLASLEE-LKRQAELDG--KSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQc 1148
Cdd:PRK03918  174 IKRRIERLEKfIKRTENIEEliKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEG- 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1149 EKENLGWQKLESEKAIKEKEYEIERLRVL---LQEEGTRKREYEnELAKVRNHYNEEMSNLR---NKYETEINITKTTIK 1222
Cdd:PRK03918  253 SKRKLEEKIRELEERIEELKKEIEELEEKvkeLKELKEKAEEYI-KLSEFYEEYLDELREIEkrlSRLEEEINGIEERIK 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1223 EISMQKEddsknlrnQLDRLSRENRDLKDEIVRLndsilqatEQRRRAEENALQQKACGSEIMQKKQHLEIElkqvmqqr 1302
Cdd:PRK03918  332 ELEEKEE--------RLEELKKKLKELEKRLEEL--------EERHELYEEAKAKKEELERLKKRLTGLTPE-------- 387

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1303 seDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNnydeeIISLKNQFETEinitkttihqltM 1382
Cdd:PRK03918  388 --KLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKG-----KCPVCGRELTE------------E 448

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1383 QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTtENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEES 1462
Cdd:PRK03918  449 HRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL-EKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEY 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1463 VRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETIN--------------KL 1528
Cdd:PRK03918  528 EKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEerlkelepfyneylEL 607

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1529 KVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKEL-----QLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRR 1603
Cdd:PRK03918  608 KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELrkeleELEKKYSEEEYEELREEYLELSRELAGLRAELEELEK 687

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1604 SLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDghLREKQRTQEEL--RRLSSEVEALRRQLLQE 1671
Cdd:PRK03918  688 RREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEE--LREKVKKYKALlkERALSKVGEIASEIFEE 755
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1104-1492 5.70e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.03  E-value: 5.70e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1104 IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRvLLQEEGT 1183
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIA-QLSKELT 757

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1184 RKREYENELAKVRNHYNEEMSNLR----------NKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEI 1253
Cdd:TIGR02168  758 ELEAEIEELEERLEEAEEELAEAEaeieeleaqiEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATE 837

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1254 VRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRsEDNARHKQSLEEAAKTIQDKNKEIERLKAE 1333
Cdd:TIGR02168  838 RRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLE-EALALLRSELEELSEELRELESKRSELRRE 916

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1334 FQEEAKRRWEYENELSKVRNnydeEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRenrslseEIKRLK 1413
Cdd:TIGR02168  917 LEELREKLAQLELRLEGLEV----RIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLEN-------KIKELG 985

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1414 NTltqtteNLRRVEEdiqqqkatGSEVSQRKQQLEVELRQVTqmrteesvrykQSLDDAAKTIQDKNKEI-ERLKQLIDK 1492
Cdd:TIGR02168  986 PV------NLAAIEE--------YEELKERYDFLTAQKEDLT-----------EAKETLEEAIEEIDREArERFKDTFDQ 1040
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1469-1841 5.94e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 81.64  E-value: 5.94e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1469 LDDAAKTIQDKNKEIERLKQLIDKETN-DRkcLEDENARLQRvQYDLQKANSSATETINKLKVQEQELTR--LRIDYERV 1545
Cdd:TIGR02168  161 FEEAAGISKYKERRKETERKLERTRENlDR--LEDILNELER-QLKSLERQAEKAERYKELKAELRELELalLVLRLEEL 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1546 SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRtasedscKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIV 1625
Cdd:TIGR02168  238 REELEELQEELKEAEEELEELTAELQELEEKLEELRL-------EVSELEEEIEELQKELYALANEISRLEQQKQILRER 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1626 KKRSEDDLRQQRDVLDGHLREKQRTQEELRR-------LSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698
Cdd:TIGR02168  311 LANLERQLEELEAQLEELESKLDELAEELAEleekleeLKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQ 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1699 SKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILElrsqlqisnnrtlELQGLINDLQRERE 1778
Cdd:TIGR02168  391 LELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELE-------------ELEEELEELQEELE 457

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1147813    1779 NLRQEIEKFQKQALEASNRIQESKNQctqvvqeresllvkikvLEQDKARLQRLEDELNRAKS 1841
Cdd:TIGR02168  458 RLEEALEELREELEEAEQALDAAERE-----------------LAQLQARLDSLERLQENLEG 503
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1392-1802 8.00e-15

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 80.94  E-value: 8.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1392 RAQIDNLTRENRSLSEEIKRLKNTLTQT-TENLRRVEEDIQQQKAtgseVSQRKQQLEVELRQVTQMRTEEsvrykqsld 1470
Cdd:pfam17380  239 RKESFNLAEDVTTMTPEYTVRYNGQTMTeNEFLNQLLHIVQHQKA----VSERQQQEKFEKMEQERLRQEK--------- 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1471 daaktiQDKNKEIERLKQLidketndrkcLEDENARlqrvQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERT 1550
Cdd:pfam17380  306 ------EEKAREVERRRKL----------EEAEKAR----QAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERI 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1551 VKDQ---DITRFQnSLKELQLQKQKVEEELnrlkRTASEDSCKRKKLEEELEgmrRSLKEQAIKITNLTQQLEQAsivKK 1627
Cdd:pfam17380  366 RQEEiamEISRMR-ELERLQMERQQKNERV----RQELEAARKVKILEEERQ---RKIQQQKVEMEQIRAEQEEA---RQ 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1628 RSEDDLRQQRDvldghlREKQRTQEELRRLSSEVEALRRQLlQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEiERLQ 1707
Cdd:pfam17380  435 REVRRLEEERA------REMERVRLEEQERQQQVERLRQQE-EERKRKKLELEKEKRDRKRAEEQRRKILEKELE-ERKQ 506

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1708 SLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILElRSQLQISNNRTLELQGLINDLQRERENLRQEIEKF 1787
Cdd:pfam17380  507 AMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEE-RRRIQEQMRKATEERSRLEAMEREREMMRQIVESE 585

                          410
                   ....*....|....*.
gi 1147813    1788 QKQA-LEASNRIQESK 1802
Cdd:pfam17380  586 KARAeYEATTPITTIK 601
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1416-1945 1.20e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 80.47  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1416 LTQTTENLRRVEEDIQQQKATgsEVSQRKQQLEVELRQVTQM--RTEESVRY-KQSLDDAAKTIQD---KNKEIERLKQL 1489
Cdd:PRK02224  182 LSDQRGSLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEieRYEEQREQaRETRDEADEVLEEheeRREELETLEAE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1490 IDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLkVQEQELTRLriDYERVSQERTVKDQDITRFQNSLKELQLQ 1569
Cdd:PRK02224  260 IEDLRETIAETEREREELAEEVRDLRERLEELEEERDDL-LAEAGLDDA--DAEAVEARREELEDRDEELRDRLEECRVA 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1570 KQKVEEELNRLKRTAS--EDSCKRKK-----LEEELEGMRRSLKEQAIKITNLTQQLEQASivkkRSEDDLRQQRDVLDG 1642
Cdd:PRK02224  337 AQAHNEEAESLREDADdlEERAEELReeaaeLESELEEAREAVEDRREEIEELEEEIEELR----ERFGDAPVDLGNAED 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1643 HLREKQRTQEELRRLSSEVEALRRQL---LQEQESVKQAHLRNEHFQKaIEDKSR--SLNESKIEIERLQSLTENLTKEH 1717
Cdd:PRK02224  413 FLEELREERDELREREAELEATLRTArerVEEAEALLEAGKCPECGQP-VEGSPHveTIEEDRERVEELEAELEDLEEEV 491

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1718 LMLE------EELRNLRLEYDDLRRGRSEAD---SDKNATILELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQ 1788
Cdd:PRK02224  492 EEVEerleraEDLVEAEDRIERLEERREDLEeliAERRETIEEKRERAE-------ELRERAAELEAEAEEKREAAAEAE 564

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1789 KQALEASNRIQESKNQCTQVVQERESL------LVKIKVLEQDKARLQ-RLED--ELNR-AKSTLEAETRVKQRLECEKQ 1858
Cdd:PRK02224  565 EEAEEAREEVAELNSKLAELKERIESLerirtlLAAIADAEDEIERLReKREAlaELNDeRRERLAEKRERKRELEAEFD 644

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1859 QiqNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEE-RCRRKLEDSTRET----QSQLETERS 1933
Cdd:PRK02224  645 E--ARIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEElRERREALENRVEAlealYDEAEELES 722

                         570
                  ....*....|..
gi 1147813   1934 RYQREIDKLRQR 1945
Cdd:PRK02224  723 MYGDLRAELRQR 734
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2291-2329 1.33e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 69.66  E-value: 1.33e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2291 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKL 2329
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1104-1723 1.61e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 80.11  E-value: 1.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1104 IKELNEKITRLTYEI---EDEKRRRKSVEDRFDQQKNDYDQLQKARqcekenlgwQKLESEKAIKEKEY-EIERLRVLLQ 1179
Cdd:PRK03918  171 IKEIKRRIERLEKFIkrtENIEELIKEKEKELEEVLREINEISSEL---------PELREELEKLEKEVkELEELKEEIE 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1180 EEGTRKREYENELAKVRnhynEEMSNLrnkyETEINITKTTIKEISmQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDs 1259
Cdd:PRK03918  242 ELEKELESLEGSKRKLE----EKIREL----EERIEELKKEIEELE-EKVKELKELKEKAEEYIKLSEFYEEYLDELRE- 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1260 iLQATEQRRRAEENALQQK-ACGSEIMQKKQHLEIELKQVMQQRSEDNARHKqsLEEAAKTIQD---------KNKEIER 1329
Cdd:PRK03918  312 -IEKRLSRLEEEINGIEERiKELEEKEERLEELKKKLKELEKRLEELEERHE--LYEEAKAKKEelerlkkrlTGLTPEK 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1330 LKAEFQEEAKRRWEYENELSKvrnnydeeIISLKNQFETEINITKTTIHQLTMQK-------EEDTSGYRAQIDN-LTRE 1401
Cdd:PRK03918  389 LEKELEELEKAKEEIEEEISK--------ITARIGELKKEIKELKKAIEELKKAKgkcpvcgRELTEEHRKELLEeYTAE 460

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1402 NRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQkatgSEVSQRKQQLEvelrqvtQMRTEESVRYKQSLDDAAKtiqdKNK 1481
Cdd:PRK03918  461 LKRIEKELKEIEEKERKLRKELRELEKVLKKE----SELIKLKELAE-------QLKELEEKLKKYNLEELEK----KAE 525

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1482 EIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTvkdQDITRFQN 1561
Cdd:PRK03918  526 EYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERL---KELEPFYN 602

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1562 SLKELQLQKQKVEEELNRLkrtasedsckrKKLEEELEGMRRSLKEQAIKITNLTQQLEQASivKKRSEDDLRQQRDvld 1641
Cdd:PRK03918  603 EYLELKDAEKELEREEKEL-----------KKLEEELDKAFEELAETEKRLEELRKELEELE--KKYSEEEYEELRE--- 666

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1642 ghlrEKQRTQEELRRLSSEVEALRRQLLQEQESVKQahLRNEhfQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLE 1721
Cdd:PRK03918  667 ----EYLELSRELAGLRAELEELEKRREEIKKTLEK--LKEE--LEEREKAKKELEKLEKALERVEELREKVKKYKALLK 738


                  ..
gi 1147813   1722 EE 1723
Cdd:PRK03918  739 ER 740
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2367-2405 2.31e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 68.89  E-value: 2.31e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2367 LLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEIL 2405
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1002-1607 2.99e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 79.34  E-value: 2.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1082 LKRQAEldgksakQNLDKCYGQIKELNEKITRLTyEIEDEKRRRKSVEDRFDQQKNDYDQLQKarqcEKENLGWQKLESE 1161
Cdd:PRK03918  260 KIRELE-------ERIEELKKEIEELEEKVKELK-ELKEKAEEYIKLSEFYEEYLDELREIEK----RLSRLEEEINGIE 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1162 KAIKEKEYEIERLRVLLQEEGTRKREYEnELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSK---NLRNQ 1238
Cdd:PRK03918  328 ERIKELEEKEERLEELKKKLKELEKRLE-ELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKakeEIEEE 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1239 LDRLSRENRDLKDEIVRLNDSILQATEQRRRAeenalqqKACGSEIMQkkqhleielkqvmQQRSEDNARHKQSLEEAAK 1318
Cdd:PRK03918  407 ISKITARIGELKKEIKELKKAIEELKKAKGKC-------PVCGRELTE-------------EHRKELLEEYTAELKRIEK 466

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1319 TIQDKNKEIERLKAEFQEEAKRRwEYENELSKVRNNYDeEIISLKNQFEtEINITKTTihqltmQKEEDTSGYRAQIDNL 1398
Cdd:PRK03918  467 ELKEIEEKERKLRKELRELEKVL-KKESELIKLKELAE-QLKELEEKLK-KYNLEELE------KKAEEYEKLKEKLIKL 537

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1399 TRENRSLSEEIKR---LKNTLTQTTENLRRVEEDIQQ-QKATGSEVSQRKQQLEVELRQVtqmrtEESVRYKQSLDDAAK 1474
Cdd:PRK03918  538 KGEIKSLKKELEKleeLKKKLAELEKKLDELEEELAElLKELEELGFESVEELEERLKEL-----EPFYNEYLELKDAEK 612

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1475 TIQDKNKEIERLKQLIDKEtndRKCLEDENARLQRVQYDLQKANSSATETinklkvqeqeltrlriDYERVSQERTVKDQ 1554
Cdd:PRK03918  613 ELEREEKELKKLEEELDKA---FEELAETEKRLEELRKELEELEKKYSEE----------------EYEELREEYLELSR 673

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813   1555 DITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLE------EELEGMRRSLKE 1607
Cdd:PRK03918  674 ELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEklekalERVEELREKVKK 732
PTZ00121 PTZ00121
MAEBL; Provisional
 1039-1841 3.67e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 79.41  E-value: 3.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1039 EELRLARDA-NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYE 1117
Cdd:PTZ00121 1191 EELRKAEDArKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQA 1270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1118 IEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLE----SEKAIKEKEYEIERLRVLLQEEGTRKREYENELA 1193
Cdd:PTZ00121 1271 AIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEeakkADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA 1350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1194 KVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEEn 1273
Cdd:PTZ00121 1351 EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEE- 1429

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1274 alqqkacgseimqKKQHLEIElKQVMQQRSEDNARHKQslEEAAKTIQDKNKEIERLKAefqEEAKRRWEYENELSKVRN 1353
Cdd:PTZ00121 1430 -------------KKKADEAK-KKAEEAKKADEAKKKA--EEAKKAEEAKKKAEEAKKA---DEAKKKAEEAKKADEAKK 1490

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1354 NYDEEiislknqfeteinitkttihqltmQKEEDtsgyraqidnltrENRSLSEEIKRlkntltqtTENLRRVEEdiqQQ 1433
Cdd:PTZ00121 1491 KAEEA------------------------KKKAD-------------EAKKAAEAKKK--------ADEAKKAEE---AK 1522

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1434 KATGSEVSQRKQQLEvELRQVTQMRTEESVRYKQSLDDAaktiQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD 1513
Cdd:PTZ00121 1523 KADEAKKAEEAKKAD-EAKKAEEKKKADELKKAEELKKA----EEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEV 1597

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1514 LQKANSSATETINKLKVQEQEltrlRIDYERVSQERTVKDQDITRFQNSLKELQLQKQ-KVEEELNR-----LKRTASED 1587
Cdd:PTZ00121 1598 MKLYEEEKKMKAEEAKKAEEA----KIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElKKAEEENKikaaeEAKKAEED 1673

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1588 SCKRKKLEEELEGMRRSlKEQAIKITNLTQQLEQasiVKKRSEDDLRQQrdvldghlrEKQRTQEELRRLssEVEALRRQ 1667
Cdd:PTZ00121 1674 KKKAEEAKKAEEDEKKA-AEALKKEAEEAKKAEE---LKKKEAEEKKKA---------EELKKAEEENKI--KAEEAKKE 1738

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1668 llQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSltENLTKEHLMLEEELRNLRLEyddlrrgRSEADSDKN- 1746
Cdd:PTZ00121 1739 --AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEK--EAVIEEELDEEDEKRRMEVD-------KKIKDIFDNf 1807

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1747 ATILELRSQLQISNNRTLELQ-GLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQD 1825
Cdd:PTZ00121 1808 ANIIEGGKEGNLVINDSKEMEdSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEA 1887

                         810
                  ....*....|....*.
gi 1147813   1826 KARLQRLEDELNRAKS 1841
Cdd:PTZ00121 1888 DEIEKIDKDDIEREIP 1903
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 929-1641 8.84e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 77.79  E-value: 8.84e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     929 EQKNLHSEISGKRDKSEEVQKiaelcansikdyelQLASYTSGLETLLN-IPIKRTMIQspsgVILQEAADVHARYIELl 1007
Cdd:TIGR02168  261 ELQELEEKLEELRLEVSELEE--------------EIEELQKELYALANeISRLEQQKQ----ILRERLANLERQLEEL- 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1008 trSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAE 1087
Cdd:TIGR02168  322 --EAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN 399

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1088 LDGKSAKQnldkcygQIKELNEKITRLTYEIEDEKRRRKSVE--------DRFDQQKNDYDQLQKARQCEKENLGWQKLE 1159
Cdd:TIGR02168  400 NEIERLEA-------RLERLEDRRERLQQEIEELLKKLEEAElkelqaelEELEEELEELQEELERLEEALEELREELEE 472

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1160 SEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNE------------EMSNLRNKYETEINIT---------- 1217
Cdd:TIGR02168  473 AEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNqsglsgilgvlsELISVDEGYEAAIEAAlggrlqavvv 552

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1218 ---KTTIKEISMQKEDDS-----------------KNLRNQLDRLSRENRDLKDEI----------------VRLNDSIL 1261
Cdd:TIGR02168  553 enlNAAKKAIAFLKQNELgrvtflpldsikgteiqGNDREILKNIEGFLGVAKDLVkfdpklrkalsyllggVLVVDDLD 632

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1262 QATEQRRRAEENA----LQQKACGSEIMQKKQHLEIElkQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEe 1337
Cdd:TIGR02168  633 NALELAKKLRPGYrivtLDGDLVRPGGVITGGSAKTN--SSILERRREIEELEEKIEELEEKIAELEKALAELRKELEE- 709

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1338 akrrweYENELSKVRNNYDEEIISLKNQfETEINITKTTIHQLtmqkEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLT 1417
Cdd:TIGR02168  710 ------LEEELEQLRKELEELSRQISAL-RKDLARLEAEVEQL----EERIAQLSKELTELEAEIEELEERLEEAEEELA 778

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1418 QTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAktiqDKNKEIERLKQLIDKETNDR 1497
Cdd:TIGR02168  779 EAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA----ATERRLEDLEEQIEELSEDI 854

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1498 KCLEDENARLqrvQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEEL 1577
Cdd:TIGR02168  855 ESLAAEIEEL---EELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRL 931

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1578 NRLK---------------RTASEDSCKRKKLEEELEGMRRSLKEQAIKITNL----TQQLEQASIVKKRSEDDLRQQRD 1638
Cdd:TIGR02168  932 EGLEvridnlqerlseeysLTLEEAEALENKIEDDEEEARRRLKRLENKIKELgpvnLAAIEEYEELKERYDFLTAQKED 1011


                   ...
gi 1147813    1639 VLD 1641
Cdd:TIGR02168 1012 LTE 1014
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2650-2686 1.03e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 66.97  E-value: 1.03e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1147813    2650 LLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMAT 2686
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQ 37
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1451-1952 1.95e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.64  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1451 LRQVTQMRteesvRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLqrvqydlqkanssaTETINKLKV 1530
Cdd:PRK03918  151 VRQILGLD-----DYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKEL--------------EEVLREINE 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1531 QEQELTRLRIDYERVSQErtVKDQDITRfqNSLKELQLQKQKVEEELnrlkrtasedsckrKKLEEELEGMRRSLKEQAI 1610
Cdd:PRK03918  212 ISSELPELREELEKLEKE--VKELEELK--EEIEELEKELESLEGSK--------------RKLEEKIRELEERIEELKK 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1611 KITNLTQQLEQASIVKKrSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLlqeqesvkqahlrnehfqKAIE 1690
Cdd:PRK03918  274 EIEELEEKVKELKELKE-KAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERI------------------KELE 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1691 DKSRSLNESKIEIERLQSLTENLTKEHLMLEEelrnLRLEYDDLRRGRSEAdsdKNATILELRSQLQISNNRTLELQGLI 1770
Cdd:PRK03918  335 EKEERLEELKKKLKELEKRLEELEERHELYEE----AKAKKEELERLKKRL---TGLTPEKLEKELEELEKAKEEIEEEI 407

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1771 NDLQRERENLRQEIEKFQKqaleASNRIQESKNQCTQVVQE-----RESLLVK----IKVLEQDKARLQRLEDELNRAKS 1841
Cdd:PRK03918  408 SKITARIGELKKEIKELKK----AIEELKKAKGKCPVCGRElteehRKELLEEytaeLKRIEKELKEIEEKERKLRKELR 483

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1842 TLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEErcrrkLEDST 1921
Cdd:PRK03918  484 ELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEE-----LKKKL 558

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1147813   1922 RETQSQLETERSRYQREIDKLRQRPYGSHRE 1952
Cdd:PRK03918  559 AELEKKLDELEEELAELLKELEELGFESVEE 589
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1445-1945 2.00e-13

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 76.88  E-value: 2.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1445 QQLEVELRQVTQMrtEESVRYKQSLDDAAKTIQdknkEIERLKQLIDKETNDRKcLEDENARLQRVQYDLQKANSSATET 1524
Cdd:COG4913  242 EALEDAREQIELL--EPIRELAERYAAARERLA----ELEYLRAALRLWFAQRR-LELLEAELEELRAELARLEAELERL 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1525 INKLKVQEQELTRLRIDYervsqeRTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTAsedsckrKKLEEELEGMRRS 1604
Cdd:COG4913  315 EARLDALREELDELEAQI------RGNGGDRLEQLEREIERLERELEERERRRARLEALL-------AALGLPLPASAEE 381

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1605 LKEQAikiTNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSS-------EVEALRRQLLQEQeSVKQ 1677
Cdd:COG4913  382 FAALR---AEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERrksnipaRLLALRDALAEAL-GLDE 457

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1678 AHLR-----------NEHFQKAIEdksRSLNESKIEI----ERLQSLTENLTKEHLmlEEELRNLRLEYDDLRRGRSEAD 1742
Cdd:COG4913  458 AELPfvgelievrpeEERWRGAIE---RVLGGFALTLlvppEHYAAALRWVNRLHL--RGRLVYERVRTGLPDPERPRLD 532

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1743 SDKNATILE---------LRSQL--------------------------QISNNRTLelqGLINDLQRERENL------R 1781
Cdd:COG4913  533 PDSLAGKLDfkphpfrawLEAELgrrfdyvcvdspeelrrhpraitragQVKGNGTR---HEKDDRRRIRSRYvlgfdnR 609

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1782 QEIEKFQKQALEASNRIQESKNQCTQVVQERESLlvkikvlEQDKARLQRLEDELNRAKSTLEAETRVkQRLECEKQQI- 1860
Cdd:COG4913  610 AKLAALEAELAELEEELAEAEERLEALEAELDAL-------QERREALQRLAEYSWDEIDVASAEREI-AELEAELERLd 681

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1861 --QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR--------------------KLE 1918
Cdd:COG4913  682 asSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAaedlarlelralleerfaaaLGD 761

                        570       580
                 ....*....|....*....|....*..
gi 1147813  1919 DSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:COG4913  762 AVERELRENLEERIDALRARLNRAEEE 788
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1358-1943 2.12e-13

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 76.32  E-value: 2.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1358 EIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRE---NRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRQLDREsdrNQELQKRIRLLEKREAEAEEALREQAELNRLKK 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1435 ATGSEVSQR---KQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQ 1511
Cdd:pfam05557   83 KYLEALNKKlneKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQ 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1512 YDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ-ERTVKDQDITRFQNS-LKELQLQKQKVEEELNRLKRTASEDSC 1589
Cdd:pfam05557  163 SSLAEAEQRIKELEFEIQSQEQDSEIVKNSKSELARiPELEKELERLREHNKhLNENIENKLLLKEEVEDLKRKLEREEK 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1590 KRKK---LEEELEGMRRSLKEQaikitnltQQLEQASIVKKRSEDDLRQqrdvldghlREKQRTQEELRrLSSEVEALRR 1666
Cdd:pfam05557  243 YREEaatLELEKEKLEQELQSW--------VKLAQDTGLNLRSPEDLSR---------RIEQLQQREIV-LKEENSSLTS 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1667 QLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNlrleYDDlRRGRSEADSDKN 1746
Cdd:pfam05557  305 SARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILES----YDK-ELTMSNYSPQLL 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1747 ATILELRSQLQISNNRTLELQGLINDLQRERENLRQeiekfQKQALEAS---NRIQESKNQCTQVVQERESLLVKIKVLE 1823
Cdd:pfam05557  380 ERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQ-----QAQTLERElqaLRQQESLADPSYSKEEVDSLRRKLETLE 454

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1824 qdkARLQRLEDElnraKSTLEaetrvkqrLECEKQQIQNDLNQWKTqysrkeeaiRKIESEREKSEREKNSLRSEIERLQ 1903
Cdd:pfam05557  455 ---LERQRLREQ----KNELE--------MELERRCLQGDYDPKKT---------KVLHLSMNPAAEAYQQRKNQLEKLQ 510

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 1147813    1904 AEIKRIEERCrRKLEDSTRETQSQLETERSRYQREIDKLR 1943
Cdd:pfam05557  511 AEIERLKRLL-KKLEDDLEQVLRLPETTSTMNFKEVLDLR 549
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1184-1607 3.07e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 76.26  E-value: 3.07e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1184 RKREYENELAKVRnHYNEEMSNLRNKYETEINITKTTIKEismqkeddsknLRNQLDRLSRENRDLKDEIVRLNDsilQA 1263
Cdd:TIGR02169  668 FSRSEPAELQRLR-ERLEGLKRELSSLQSELRRIENRLDE-----------LSQELSDASRKIGEIEKEIEQLEQ---EE 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1264 TEQRRRAEENALQQKACGSEIMQKKQHLEiELKQVMQQRSEDNARHKQSLEE-----AAKTIQDKNKEIERLKAEFQEEA 1338
Cdd:TIGR02169  733 EKLKERLEELEEDLSSLEQEIENVKSELK-ELEARIEELEEDLHKLEEALNDlearlSHSRIPEIQAELSKLEEEVSRIE 811

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1339 KRRWEYENELSKVrnNYDEEIISLKNQFETEINItkttihQLTMQKEEdtsgYRAQIDNLTRENRSLSEEIKRLKNTLTQ 1418
Cdd:TIGR02169  812 ARLREIEQKLNRL--TLEKEYLEKEIQELQEQRI------DLKEQIKS----IEKEIENLNGKKEELEEELEELEAALRD 879

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1419 TTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQvtqmrteESVRYKQsLDDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
Cdd:TIGR02169  880 LESRLGDLKKERDELEAQLRELERKIEELEAQIEK-------KRKRLSE-LKAKLEALEEELSEIEDPKGEDEEIPEEEL 951

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1499 CLEDENARLQRVQYDLQkanssATETINKLKVQEQELTRLRidyervsqertvkdqditrfqnsLKELQLQKQKVEEELN 1578
Cdd:TIGR02169  952 SLEDVQAELQRVEEEIR-----ALEPVNMLAIQEYEEVLKR-----------------------LDELKEKRAKLEEERK 1003

                          410       420       430
                   ....*....|....*....|....*....|
gi 1147813    1579 RL-KRTASEDSCKRKKLEEELEGMRRSLKE 1607
Cdd:TIGR02169 1004 AIlERIEEYEKKKREVFMEAFEAINENFNE 1033
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2124-2162 1.66e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 63.89  E-value: 1.66e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2124 LLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSL 2162
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1407-1848 1.84e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 73.26  E-value: 1.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1407 EEIKRLKNTLTQTTENLRRVEEDIQQQKatgsEVSQRKQQLEVELRQVTQMRteESVRYKQSLDDAAKTIQDKNKEIERL 1486
Cdd:COG4717   71 KELKELEEELKEAEEKEEEYAELQEELE----ELEEELEELEAELEELREEL--EKLEKLLQLLPLYQELEALEAELAEL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1487 KQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQ-EQELTRLRIDYERVSQErtvkdqdITRFQNSLKE 1565
Cdd:COG4717  145 PERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLAtEEELQDLAEELEELQQR-------LAELEEELEE 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1566 LQLQKQKVEEELNRLKRTAsEDSCKRKKLEEE------------LEGMRRSLKEQAIKITNLTQQLEQ----ASIVKKRS 1629
Cdd:COG4717  218 AQEELEELEEELEQLENEL-EAAALEERLKEArlllliaaallaLLGLGGSLLSLILTIAGVLFLVLGllalLFLLLARE 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1630 EDDLRQQRDVLDGHLREKQRTQEELRRLsseVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEiERLQSL 1709
Cdd:COG4717  297 KASLGKEAEELQALPALEELEEEELEEL---LAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLE-ELEQEI 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1710 TENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLE-LQGLINDLQRERENLRQEIEKFQ 1788
Cdd:COG4717  373 AALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEeLEEELEELEEELEELEEELEELR 452

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813  1789 KQALEASNRIQ--ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETR 1848
Cdd:COG4717  453 EELAELEAELEqlEEDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERL 514
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1199-1765 1.87e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 73.54  E-value: 1.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1199 YNEEMSNLRNKYETEINITKTTIKEISMQKED-DSKNLRNQLDRLSRENRDLKDEIVRLNdsilqatEQRRRAEENALQQ 1277
Cdd:PRK02224  167 YRERASDARLGVERVLSDQRGSLDQLKAQIEEkEEKDLHERLNGLESELAELDEEIERYE-------EQREQARETRDEA 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1278 KACGSEIMQKKQHLEiELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEE--------------AKRRWE 1343
Cdd:PRK02224  240 DEVLEEHEERREELE-TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLlaeaglddadaeavEARREE 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1344 YENELSKVRNNYDEEIISLKnQFETEINITKTTIHQLTMQKEE----------DTSGYRAQIDNLTRENRSLSEEIKRLK 1413
Cdd:PRK02224  319 LEDRDEELRDRLEECRVAAQ-AHNEEAESLREDADDLEERAEElreeaaelesELEEAREAVEDRREEIEELEEEIEELR 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1414 NTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVtqmrtEESVRYKQSLDDAAK---------------TIQD 1478
Cdd:PRK02224  398 ERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTA-----RERVEEAEALLEAGKcpecgqpvegsphveTIEE 472

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1479 KNKEIERLKQLIDKETNDRKCLEDENARLQrvqyDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
Cdd:PRK02224  473 DRERVEELEAELEDLEEEVEEVEERLERAE----DLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAE 548

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1559 FQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRsLKEQAIKITNLTQQLEqaSIVKKRseDDLRQQRD 1638
Cdd:PRK02224  549 LEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER-IRTLLAAIADAEDEIE--RLREKR--EALAELND 623

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1639 VLDGHLREKqrtQEELRRLSSEVEALRRQLLQEQesvkqaHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHL 1718
Cdd:PRK02224  624 ERRERLAEK---RERKRELEAEFDEARIEEARED------KERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELE 694

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 1147813   1719 MLEEELRNLRLEYDDLRRGRSEADSDKNaTILELRSQLQISNNRTLE 1765
Cdd:PRK02224  695 ELRERREALENRVEALEALYDEAEELES-MYGDLRAELRQRNVETLE 740
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1238-1968 2.31e-12

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 73.41  E-value: 2.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1238 QLDRLSRENRDLKDEIVRLNDsILQATEQRRRAEENALQQKACGSEIMQKKQHLEIEL-KQVMQQRSEDNARHKQSLEEA 1316
Cdd:COG4913  236 DLERAHEALEDAREQIELLEP-IRELAERYAAARERLAELEYLRAALRLWFAQRRLELlEAELEELRAELARLEAELERL 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1317 AKTIQDKNKEIERLKA-----------EFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETeinitktTIHQLTMQKE 1385
Cdd:COG4913  315 EARLDALREELDELEAqirgnggdrleQLEREIERLERELEERERRRARLEALLAALGLPLPA-------SAEEFAALRA 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1386 EdtsgYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEEsVRY 1465
Cdd:COG4913  388 E----AAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEALGLDEAE-LPF 462

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1466 kqslddAAKTIQDKNKE------IER------LKQLIDKEtndrkcledenarlqrvQYDlqkansSATETINKLKvqeq 1533
Cdd:COG4913  463 ------VGELIEVRPEEerwrgaIERvlggfaLTLLVPPE-----------------HYA------AALRWVNRLH---- 509

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1534 elTRLRIDYERVsQERTVKDQDITRFQNSL-KELQLQKQK----VEEELNRLKRTASEDSckrkklEEELEGMRRslkeq 1608
Cdd:COG4913  510 --LRGRLVYERV-RTGLPDPERPRLDPDSLaGKLDFKPHPfrawLEAELGRRFDYVCVDS------PEELRRHPR----- 575

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1609 AIKITNLTQQLEQAsiVKKRSEDDLRQQRdVLdGhlrekQRTQEELRRLSSEVEALRRQLLQEQESVKQAhlrnehfqka 1688
Cdd:COG4913  576 AITRAGQVKGNGTR--HEKDDRRRIRSRY-VL-G-----FDNRAKLAALEAELAELEEELAEAEERLEAL---------- 636

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1689 iEDKSRSLNESKIEIERLQSLTENLtKEHLMLEEELRNLRLEYDDLRRGrseadsdkNATILELRSQLQisnnrtlelqg 1768
Cdd:COG4913  637 -EAELDALQERREALQRLAEYSWDE-IDVASAEREIAELEAELERLDAS--------SDDLAALEEQLE----------- 695

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1769 linDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQvVQERESLLVKIKVLEQDKARLQRLEDELNRAkstLEAETR 1848
Cdd:COG4913  696 ---ELEAELEELEEELDELKGEIGRLEKELEQAEEELDE-LQDRLEAAEDLARLELRALLEERFAAALGDA---VERELR 768

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1849 vkqrlecekQQIQNDLNQWKTQYSRKEEAIRKIESE-----REKSEREKNSLRS--EIERLQAEIKRI-----EERCRRK 1916
Cdd:COG4913  769 ---------ENLEERIDALRARLNRAEEELERAMRAfnrewPAETADLDADLESlpEYLALLDRLEEDglpeyEERFKEL 839

                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1917 LEDSTRET----QSQLETERSRYQREIDK----LRQRPYGSHRETQTECEWTVDTSKLVF 1968
Cdd:COG4913  840 LNENSIEFvadlLSKLRRAIREIKERIDPlndsLKRIPFGPGRYLRLEARPRPDPEVREF 899
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2048-2086 3.46e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 62.73  E-value: 3.46e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2048 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQI 2086
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1563-1945 4.06e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 72.11  E-value: 4.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1563 LKELQLQKQKVEEELNRLKRTASEdsckRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSE-----DDLRQQR 1637
Cdd:COG4717   73 LKELEEELKEAEEKEEEYAELQEE----LEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEAleaelAELPERL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1638 DVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRN-EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKE 1716
Cdd:COG4717  149 EELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEElQDLAEELEELQQRLAELEEELEEAQEELEELEEE 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1717 HLMLEEELRNLRLEyDDLRRGRSEADSdkNATILELRSQLQISNNRTLELQGLI-----------NDLQRERENLRQEIE 1785
Cdd:COG4717  229 LEQLENELEAAALE-ERLKEARLLLLI--AAALLALLGLGGSLLSLILTIAGVLflvlgllallfLLLAREKASLGKEAE 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1786 KFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLeaetrvkqRLECEKQQIQNDLN 1865
Cdd:COG4717  306 ELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--------QLEELEQEIAALLA 377

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1866 QWKTQysrKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:COG4717  378 EAGVE---DEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREE 454
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1396-2008 1.15e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.86  E-value: 1.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1396 DNLTRENRSLSEEIKRLKNTLTQTTEnlrrVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQsLDDAAKT 1475
Cdd:PRK03918  165 KNLGEVIKEIKRRIERLEKFIKRTEN----IEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKE-LEELKEE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1476 IQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKAnssaTETINKLKVQEQELTRLRIDYERVSQERTVKDQD 1555
Cdd:PRK03918  240 IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEK----VKELKELKEKAEEYIKLSEFYEEYLDELREIEKR 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1556 ITRFQNSLKELQLQKQKVEEELNRLKRTasedsckrKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDdlrQ 1635
Cdd:PRK03918  316 LSRLEEEINGIEERIKELEEKEERLEEL--------KKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTG---L 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1636 QRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQA----------------HLRNEHFQKAIEDKSRSLNES 1699
Cdd:PRK03918  385 TPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAieelkkakgkcpvcgrELTEEHRKELLEEYTAELKRI 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1700 KIEIERLQSLTENLTKEhlmlEEELRNLRLEYDDLRRGRSEADSdknatILELRSQLQISNNRTLELQglindlQREREN 1779
Cdd:PRK03918  465 EKELKEIEEKERKLRKE----LRELEKVLKKESELIKLKELAEQ-----LKELEEKLKKYNLEELEKK------AEEYEK 529

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1780 LRQE---IEKFQKQALEASNRIQESKNqctqvvqERESLLVKIKVLEQDKARLQRLEDELNrAKSTLEAETRVKqrlecE 1856
Cdd:PRK03918  530 LKEKlikLKGEIKSLKKELEKLEELKK-------KLAELEKKLDELEEELAELLKELEELG-FESVEELEERLK-----E 596

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1857 KQQIQNDLNQWKTQYSRKEEAIRKIEsereKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQ 1936
Cdd:PRK03918  597 LEPFYNEYLELKDAEKELEREEKELK----KLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELS 672

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1937 REIDKLRQRPYG--SHREtqtECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKS---------VEEVA 2005
Cdd:PRK03918  673 RELAGLRAELEEleKRRE---EIKKTLEKLKEELEEREKAKKELEKLEKALERVEELREKVKKYKAllkeralskVGEIA 749


                  ...
gi 1147813   2006 SEI 2008
Cdd:PRK03918  750 SEI 752
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1289-1945 1.15e-11

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 70.77  E-value: 1.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1289 QHLEIELKQvmQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNnydEEIISLKNQFET 1368
Cdd:TIGR00618  229 KHLREALQQ--TQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARK---AAPLAAHIKAVT 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1369 EINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLsEEIKRLKNTLTQTTENLRRVEEdiqqQKATGSEVSQRKQQLE 1448
Cdd:TIGR00618  304 QIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSI-EEQRRLLQTLHSQEIHIRDAHE----VATSIREISCQQHTLT 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1449 VELRQVTQMRTeesvrykqslddaakTIQDKNKEierLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSsatetinKL 1528
Cdd:TIGR00618  379 QHIHTLQQQKT---------------TLTQKLQS---LCKELDILQREQATIDTRTSAFRDLQGQLAHAKK-------QQ 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1529 KVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEdsckRKKLEEELEGMRRSLKEQ 1608
Cdd:TIGR00618  434 ELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAV----VLARLLELQEEPCPLCGS 509

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1609 AIkitnltqQLEQAsivkkrseddlRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKA 1688
Cdd:TIGR00618  510 CI-------HPNPA-----------RQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQS 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1689 IEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDknatiLELRSQLQisnNRTLELQG 1768
Cdd:TIGR00618  572 FSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDL-----QDVRLHLQ---QCSQELAL 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1769 LINDLQRERENLRQE--------IEKFQKQALEAS-NRIQESKNQCTQVVQERESL---LVKIKVLEQDKARLQRLEDEL 1836
Cdd:TIGR00618  644 KLTALHALQLTLTQErvrehalsIRVLPKELLASRqLALQKMQSEKEQLTYWKEMLaqcQTLLRELETHIEEYDREFNEI 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1837 NRAKSTLEAEtrVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSL----------RSEIERLQAEI 1906
Cdd:TIGR00618  724 ENASSSLGSD--LAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELshlaaeiqffNRLREEDTHLL 801

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 1147813    1907 KRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:TIGR00618  802 KTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEK 840
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1021-1492 1.23e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 70.43  E-value: 1.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1021 LKSLED-LKLKNTKIEVL--EEELRLARDANSENCNKNKFLDQ---NLQKYQAECSQFKAKLASLEELKRQAELDGKSAK 1094
Cdd:TIGR04523  283 IKELEKqLNQLKSEISDLnnQKEQDWNKELKSELKNQEKKLEEiqnQISQNNKIISQLNEQISQLKKELTNSESENSEKQ 362

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1095 QNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKArqcekenlgWQKLESEKAIKEKeyEIERL 1174
Cdd:TIGR04523  363 RELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ---------IKKLQQEKELLEK--EIERL 431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1175 RVLLQEEGTRKREYENELAKVRNHYNeEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLR---NQLDRLSRENRDLKD 1251
Cdd:TIGR04523  432 KETIIKNNSEIKDLTNQDSVKELIIK-NLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKskeKELKKLNEEKKELEE 510

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1252 EIVRLNDSILQATEqrrraeenalQQKACGSEIMQKKQhleiELKQVMQQRSEDNARHKQSLEEaaKTIQDKNKEIERLK 1331
Cdd:TIGR04523  511 KVKDLTKKISSLKE----------KIEKLESEKKEKES----KISDLEDELNKDDFELKKENLE--KEIDEKNKEIEELK 574

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1332 AEFQEEAKRRWEYENELSKvrnnYDEEIISLKNQFETEInitkTTIHQLTmqkeedtsgyrAQIDNLTRENRSLSEEIKR 1411
Cdd:TIGR04523  575 QTQKSLKKKQEEKQELIDQ----KEKEKKDLIKEIEEKE----KKISSLE-----------KELEKAKKENEKLSSIIKN 635

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1412 LKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQ-MRT---EESVRYKQSLDDAAKT-----IQDKNKE 1482
Cdd:TIGR04523  636 IKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIElMKDwlkELSLHYKKYITRMIRIkdlpkLEEKYKE 715

                          490
                   ....*....|
gi 1147813    1483 IERLKQLIDK 1492
Cdd:TIGR04523  716 IEKELKKLDE 725
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1094-1909 4.12e-11

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 69.31  E-value: 4.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1094 KQNLDKCYGQIKELNEKITRltyEIEDEKRrrKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE--KAIKEKEYEI 1171
Cdd:TIGR01612  859 KEKIDSEHEQFAELTNKIKA---EISDDKL--NDYEKKFNDSKSLINEINKSIEEEYQNINTLKKVDEyiKICENTKESI 933

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1172 ERLRvllqEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNqlDRLSRENRDLKD 1251
Cdd:TIGR01612  934 EKFH----NKQNILKEILNKNIDTIKESNLIEKSYKDKFDNTLIDKINELDKAFKDASLNDYEAKN--NELIKYFNDLKA 1007

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1252 EIVRLNDSILQATEQRRRAEENALQQKAcgSEIMQKKQHLEIELKQVMQQRSED---------NARHKQSLEEAAKTIQD 1322
Cdd:TIGR01612 1008 NLGKNKENMLYHQFDEKEKATNDIEQKI--EDANKNIPNIEIAIHTSIYNIIDEiekeigkniELLNKEILEEAEINITN 1085

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1323 KNKEIERLK----AEFQEEAKRRweYENELSKVRN---NYDEEI-------ISLKNQFETEINITKTTIHQL-----TMQ 1383
Cdd:TIGR01612 1086 FNEIKEKLKhynfDDFGKEENIK--YADEINKIKDdikNLDQKIdhhikalEEIKKKSENYIDEIKAQINDLedvadKAI 1163

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1384 KEEDTSGYRAQIDNLTRE---NRSLSEEIKRLKNTLTQTTENLRRVE------------------EDIQQQKATGS---- 1438
Cdd:TIGR01612 1164 SNDDPEEIEKKIENIVTKidkKKNIYDEIKKLLNEIAEIEKDKTSLEevkginlsygknlgklflEKIDEEKKKSEhmik 1243

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1439 ----------EVSQRKQQLEVELRQVTQMRTEESVrYKQSLDDAAK---TIQDKNKEIE--RLKQLIDKETNDRKC-LED 1502
Cdd:TIGR01612 1244 ameayiedldEIKEKSPEIENEMGIEMDIKAEMET-FNISHDDDKDhhiISKKHDENISdiREKSLKIIEDFSEESdIND 1322

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1503 ENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIdyERVSQERTVKDQDITRFQNSLKElqlQKQKVEEELNRLKR 1582
Cdd:TIGR01612 1323 IKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLNKI--KKIIDEVKEYTKEIEENNKNIKD---ELDKSEKLIKKIKD 1397

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1583 TASEDSCKrKKLEEELEGMRRSLKEQAIKIT-----------------------NLTQQLEQASIVKKRSEDDLRQQRDV 1639
Cdd:TIGR01612 1398 DINLEECK-SKIESTLDDKDIDECIKKIKELknhilseesnidtyfknadenneNVLLLFKNIEMADNKSQHILKIKKDN 1476

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1640 ----LDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQ-----AHLRNEHFQKAIEDK-SRSLNESKIEIERLQSL 1709
Cdd:TIGR01612 1477 atndHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKELFEQykkdvTELLNKYSALAIKNKfAKTKKDSEIIIKEIKDA 1556

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1710 TENLTKEHLMLEEELRNLRLEydDLRRGRSEADSDK-NATILELRSQLQISNNRTLElqglINDLQRERENLRQEIEKFQ 1788
Cdd:TIGR01612 1557 HKKFILEAEKSEQKIKEIKKE--KFRIEDDAAKNDKsNKAAIDIQLSLENFENKFLK----ISDIKKKINDCLKETESIE 1630

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1789 KQALEASNRIQESKnqctqvvqeresllvkIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWK 1868
Cdd:TIGR01612 1631 KKISSFSIDSQDTE----------------LKENGDNLNSLQEFLESLKDQKKNIEDKKKELDELDSEIEKIEIDVDQHK 1694

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|.
gi 1147813    1869 TQYSrkeeaIRKIESEREKSEREKNSLRSEIERLQAEIKRI 1909
Cdd:TIGR01612 1695 KNYE-----IGIIEKIKEIAIANKEEIESIKELIEPTIENL 1730
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1554-1797 4.28e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 67.48  E-value: 4.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1634 RQQRDVLDGHLREKQRtqeelrrlSSEVEALrrQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENL 1713
Cdd:COG4942  100 EAQKEELAELLRALYR--------LGRQPPL--ALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1714 TKEHLMLEEELRNLRLEYDDLRRGRSEadsdKNATILELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQKQALE 1793
Cdd:COG4942  170 EAERAELEALLAELEEERAALEALKAE----RQKLLARLEKELA-------ELAAELAELQQEAEELEALIARLEAEAAA 238


                 ....
gi 1147813  1794 ASNR 1797
Cdd:COG4942  239 AAER 242
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1062-1787 4.88e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 68.79  E-value: 4.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLdkcygqikeLNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQ 1141
Cdd:COG4913  257 IRELAERYAAARERLAELEYLRAALRLWFAQRRLEL---------LEAELEELRAELARLEAELERLEARLDALREELDE 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1142 LQKARQcekeNLGWQKLESEKAikekeyEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYEtEINITKTTI 1221
Cdd:COG4913  328 LEAQIR----GNGGDRLEQLER------EIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRA-EAAALLEAL 396

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRL---NDSILQATEQRRRAEENALQQKacgseimqkkqhlEIELKQV 1298
Cdd:COG4913  397 EEELEALEEALAEAEAALRDLRRELRELEAEIASLerrKSNIPARLLALRDALAEALGLD-------------EAELPFV 463

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1299 ---MQQRSEDnarhkQSLEEAaktiqdknkeIERLKAEF---------QEEAKRRWeYENELSKVRNNYDEEIISLKNQF 1366
Cdd:COG4913  464 gelIEVRPEE-----ERWRGA----------IERVLGGFaltllvppeHYAAALRW-VNRLHLRGRLVYERVRTGLPDPE 527

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1367 ETEINItKTTIHQLTMqkeeDTSGYRAQIDNLTRENRSL-----SEEIKRLKNTLT---QTTENLRRVEEDIQQQKA--- 1435
Cdd:COG4913  528 RPRLDP-DSLAGKLDF----KPHPFRAWLEAELGRRFDYvcvdsPEELRRHPRAITragQVKGNGTRHEKDDRRRIRsry 602

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1436 -TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQsLDDAAKTIQDKNKEIERLKQLIDKETnDRKCLEDENARLQRVQYDL 1514
Cdd:COG4913  603 vLGFDNRAKLAALEAELAELEEELAEAEERLEA-LEAELDALQERREALQRLAEYSWDEI-DVASAEREIAELEAELERL 680

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1515 QKANSsatetinKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSckRKKL 1594
Cdd:COG4913  681 DASSD-------DLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLEL--RALL 751

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1595 EEELEGMRRSLKEQAIKiTNLTQQLEQASIVKKRSEDDLRQQRDvldghlREKQRTQEELRRLSSEVEALR--RQLLQEq 1672
Cdd:COG4913  752 EERFAAALGDAVERELR-ENLEERIDALRARLNRAEEELERAMR------AFNREWPAETADLDADLESLPeyLALLDR- 823

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1673 esvkqahLRNEHFQKAIEDKSRSLNESKIE-IERLQSlteNLTKEHLMLEEELRNL-----RLEYDDLRRGRSEADSDKN 1746
Cdd:COG4913  824 -------LEEDGLPEYEERFKELLNENSIEfVADLLS---KLRRAIREIKERIDPLndslkRIPFGPGRYLRLEARPRPD 893

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....
gi 1147813  1747 ATILELRSQL-QISNNRTLE-----------LQGLINDLQ-RERENLRQEIEKF 1787
Cdd:COG4913  894 PEVREFRQELrAVTSGASLFdeelsearfaaLKRLIERLRsEEEESDRRWRARV 947
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
865-1498 4.88e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.94  E-value: 4.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    865 DRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDRKRRQDSLESM---KFGDSNTVMRFLNEQKNLHSEISGKR 941
Cdd:PRK03918  165 KNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSElpeLREELEKLEKEVKELEELKEEIEELE 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    942 DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIpIKRtmiqspsgviLQEAADVHARYIELLtrsgdyyRFLSEML 1021
Cdd:PRK03918  245 KELESLEGSKRKLEEKIRELEERIEELKKEIEELEEK-VKE----------LKELKEKAEEYIKLS-------EFYEEYL 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR-QAELDGKSAK---QNL 1097
Cdd:PRK03918  307 DELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAkKEELERLKKRltgLTP 386

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1098 DKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR-QCEKENLGWQKLESEKAIKEKEYEIERLRV 1176
Cdd:PRK03918  387 EKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKgKCPVCGRELTEEHRKELLEEYTAELKRIEK 466

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1177 LLQEEGTRKREYENELAKVRNHYNEEMSNLRNK------YETEINITKTTIKEISmQKEDDSKNLRNQLDRLSRENRDLK 1250
Cdd:PRK03918  467 ELKEIEEKERKLRKELRELEKVLKKESELIKLKelaeqlKELEEKLKKYNLEELE-KKAEEYEKLKEKLIKLKGEIKSLK 545

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1251 DEIVRLNDsilqaTEQRRRAEENALQqkacgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEE----------AAKTI 1320
Cdd:PRK03918  546 KELEKLEE-----LKKKLAELEKKLD------ELEEELAELLKELEELGFESVEELEERLKELEPfyneylelkdAEKEL 614

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1321 QDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEeiisLKNQFEteinitkttihqltmqkEEDTSGYRAQIDNLTR 1400
Cdd:PRK03918  615 EREEKELKKLEEELDKAFEELAETEKRLEELRKELEE----LEKKYS-----------------EEEYEELREEYLELSR 673

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1401 ENRSLSEEIKRLKNTLTQTTENLrrveEDIQQQKATGSEVSQRKQQLEVELRQVTQMRtEESVRYKQSLDDAAKtiqdkn 1480
Cdd:PRK03918  674 ELAGLRAELEELEKRREEIKKTL----EKLKEELEEREKAKKELEKLEKALERVEELR-EKVKKYKALLKERAL------ 742

                         650
                  ....*....|....*...
gi 1147813   1481 KEIERLKQLIDKETNDRK 1498
Cdd:PRK03918  743 SKVGEIASEIFEELTEGK 760
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1505-1945 4.92e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 68.64  E-value: 4.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1505 ARLQRVQYDLQKANSSATE-TINKLKVQEQELTRLRIDYERVSQERtvkdQDITRFQNSLKELQLQKQKVEEELNRLKR- 1582
Cdd:COG4717   49 ERLEKEADELFKPQGRKPElNLKELKELEEELKEAEEKEEEYAELQ----EELEELEEELEELEAELEELREELEKLEKl 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1583 -TASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQasivKKRSEDDLRQQRDVLDGHLREK-QRTQEELRRLSSE 1660
Cdd:COG4717  125 lQLLPLYQELEALEAELAELPERLEELEERLEELRELEEE----LEELEAELAELQEELEELLEQLsLATEEELQDLAEE 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1661 VEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEiERLQSL----------------------TENLTKEHL 1718
Cdd:COG4717  201 LEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE-ERLKEArlllliaaallallglggsllsLILTIAGVL 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1719 MLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER-ENLRQEIEKFQKQALEASNR 1797
Cdd:COG4717  280 FLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEElLELLDRIEELQELLREAEEL 359

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1798 IQESKNQCTQvvQERESLLVKIKV--------LEQDKARLQRLEDELNRAKSTLEAETRvkqrlECEKQQIQNDLNQWKT 1869
Cdd:COG4717  360 EEELQLEELE--QEIAALLAEAGVedeeelraALEQAEEYQELKEELEELEEQLEELLG-----ELEELLEALDEEELEE 432

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1147813  1870 QYSRKEEAIrkieserekserekNSLRSEIERLQAEIKRIEERCRRKLEDstrETQSQLETERSRYQREIDKLRQR 1945
Cdd:COG4717  433 ELEELEEEL--------------EELEEELEELREELAELEAELEQLEED---GELAELLQELEELKAELRELAEE 491
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1256-1941 6.08e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 68.21  E-value: 6.08e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1256 LNDSILQATEQRRRAEENALQQkacGSEIMQKKQHLEIELKQVMQQRSEDnarhKQSLEEAAKTIQDKNKEIERLKAEFQ 1335
Cdd:pfam05483   65 LKDSDFENSEGLSRLYSKLYKE---AEKIKKWKVSIEAELKQKENKLQEN----RKIIEAQRKAIQELQFENEKVSLKLE 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1336 EEAKRRWEYENELSKVRNnydeeiisLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNT 1415
Cdd:pfam05483  138 EEIQENKDLIKENNATRH--------LCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENA 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1416 LTQTTENLRRVEEDIQQ-QKATGSEVSQRKQQLEVELRQVTQM--RTEESVRYKQSLDDAAKTIQDKNK-EIERLKQLID 1491
Cdd:pfam05483  210 RLEMHFKLKEDHEKIQHlEEEYKKEINDKEKQVSLLLIQITEKenKMKDLTFLLEESRDKANQLEEKTKlQDENLKELIE 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1492 KETNDRKCLEDENARLQR---VQYDLQKANSSATETINKLkVQEQEltrlrIDYERVSQERTVKDQDITRFQN---SLKE 1565
Cdd:pfam05483  290 KKDHLTKELEDIKMSLQRsmsTQKALEEDLQIATKTICQL-TEEKE-----AQMEELNKAKAAHSFVVTEFEAttcSLEE 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1566 L-QLQKQKVEEELNRLKRTASEdsckRKKLEEELEGMRRSLKEQAIKITNLTQQLEQasivkkrsEDDLRQQRDVLDGHL 1644
Cdd:pfam05483  364 LlRTEQQRLEKNEDQLKIITME----LQKKSSELEEMTKFKNNKEVELEELKKILAE--------DEKLLDEKKQFEKIA 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1645 REKQRTQEELRRLsseVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEEL 1724
Cdd:pfam05483  432 EELKGKEQELIFL---LQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEA 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1725 RNLRLEYDdlrrgrseadsdknatilelRSQLQISNNRTLELQGL--INDLQRERENLRQEIEKFQKQALEASNRIQesk 1802
Cdd:pfam05483  509 SDMTLELK--------------------KHQEDIINCKKQEERMLkqIENLEEKEMNLRDELESVREEFIQKGDEVK--- 565

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1803 nqCTQVVQERESLLVKIKVLEQDKaRLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1882
Cdd:pfam05483  566 --CKLDKSEENARSIEYEVLKKEK-QMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLE 642

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813    1883 SEREKSEREKNSLRSEIERlQAEIKRIEErcrRKLEDSTRETQSQLEtERSRYQREIDK 1941
Cdd:pfam05483  643 LELASAKQKFEEIIDNYQK-EIEDKKISE---EKLLEEVEKAKAIAD-EAVKLQKEIDK 696
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 285-450 6.19e-11

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 64.77  E-value: 6.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:cd00176   15 WLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELREL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   365 TKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKErekILEYKRQVQNLVNKSKK 444
Cdd:cd00176   95 AEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEE---LEAHEPRLKSLNELAEE 171


                 ....*.
gi 1147813   445 IVQLKP 450
Cdd:cd00176  172 LLEEGH 177
PTZ00121 PTZ00121
MAEBL; Provisional
 1018-1520 1.88e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.09  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1018 SEMLKSLEDLKLKNTKIEVLEEELRLARDA-NSENCNKnkfldQNLQKYQAECSQFKAKLA-SLEELKRQAELDGKSA-- 1093
Cdd:PTZ00121 1427 AEEKKKADEAKKKAEEAKKADEAKKKAEEAkKAEEAKK-----KAEEAKKADEAKKKAEEAkKADEAKKKAEEAKKKAde 1501

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1094 ---KQNLDKCYGQIKELNEKitRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCekenlgwQKLESEKAIKEKEYE 1170
Cdd:PTZ00121 1502 akkAAEAKKKADEAKKAEEA--KKADEAKKAEEAKKADEAKKAEEKKKADELKKAEEL-------KKAEEKKKAEEAKKA 1572

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1171 IERLRVLLQEEGTRKREYENELAKVRNHYNEEMsnlRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLK 1250
Cdd:PTZ00121 1573 EEDKNMALRKAEEAKKAEEARIEEVMKLYEEEK---KMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKA 1649

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1251 DEIVRLND-SILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
Cdd:PTZ00121 1650 EELKKAEEeNKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENK 1729

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1330 LKAefqEEAKRRWEYENELSKVRNNYDEEiislknqfeteinitKTTIHQLTMQKEEDTSGYRAQIDNLTREnrSLSEEI 1409
Cdd:PTZ00121 1730 IKA---EEAKKEAEEDKKKAEEAKKDEEE---------------KKKIAHLKKEEEKKAEEIRKEKEAVIEE--ELDEED 1789

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1410 KRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEV----ELRQVTQMRTEESVRYKQ-SLDDAAKTIQDKNKEIE 1484
Cdd:PTZ00121 1790 EKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDsaikEVADSKNMQLEEADAFEKhKFNKNNENGEDGNKEAD 1869

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 1147813   1485 RLKQLIDKETNDRKCLE-DENARLQRVQYDLQKANSS 1520
Cdd:PTZ00121 1870 FNKEKDLKEDDEEEIEEaDEIEKIDKDDIEREIPNNN 1906
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1314-2008 3.15e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 66.15  E-value: 3.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1314 EEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYR- 1392
Cdd:pfam02463  182 TENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIe 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1393 ------AQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYK 1466
Cdd:pfam02463  262 keeeklAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1467 QSLDDAAKTIQDKNKEIERLKQlidketndrkcLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTrlridyERVS 1546
Cdd:pfam02463  342 KELKELEIKREAEEEEEEELEK-----------LQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELK------SEEE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1547 QERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVK 1626
Cdd:pfam02463  405 KEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQE 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1627 KRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRrqllqeqesVKQAHLRNEHFQKAIEDKSRsLNESKIEIERL 1706
Cdd:pfam02463  485 QLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGR---------IISAHGRLGDLGVAVENYKV-AISTAVIVEVS 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1707 QSLTENLTKEHLMLEEELRNLRLeydDLRRGRSEADSDKNATILELrSQLQISNNRTLELQGLINDLQRERENLRQEIEK 1786
Cdd:pfam02463  555 ATADEVEERQKLVRALTELPLGA---RKLRLLIPKLKLPLKSIAVL-EIDPILNLAQLDKATLEADEDDKRAKVVEGILK 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1787 FQKQA-LEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLN 1865
Cdd:pfam02463  631 DTELTkLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKE 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1866 QWKTQYSRKEEA-IRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1944
Cdd:pfam02463  711 ELKKLKLEAEELlADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEE 790

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1147813    1945 RPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEI 2008
Cdd:pfam02463  791 EKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEE 854
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1239-1782 3.19e-10

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 66.08  E-value: 3.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1239 LDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNarhkqSLEEAAK 1318
Cdd:PRK01156  185 IDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKN-----RYESEIK 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1319 TIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLT-----MQKEEDTSGYRA 1393
Cdd:PRK01156  260 TAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINkyhaiIKKLSVLQKDYN 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1394 QIDNLTRENRSLSEEIKRLK------NTLTQTTENLRR-VEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYK 1466
Cdd:PRK01156  340 DYIKKKSRYDDLNNQILELEgyemdyNSYLKSIESLKKkIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQ 419

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1467 Q------SLDDAAKTIQDKNKEIERLKQLIDK------------ETNDRKCLEDENARLQRVQYDLQKANSSATETINKL 1528
Cdd:PRK01156  420 DisskvsSLNQRIRALRENLDELSRNMEMLNGqsvcpvcgttlgEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKI 499

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1529 KVQEQELTRLRID----YERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSckRKKLEEELEGM-RR 1603
Cdd:PRK01156  500 VDLKKRKEYLESEeinkSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDL--DSKRTSWLNALaVI 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1604 SLkeqaIKITNLTQQLEQasiVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAhlrnE 1683
Cdd:PRK01156  578 SL----IDIETNRSRSNE---IKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILI----E 646

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1684 HFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHlmleeelrnlrleyDDLRRGRSEADsDKNATILELRSQLQISNNRT 1763
Cdd:PRK01156  647 KLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIE--------------DNLKKSRKALD-DAKANRARLESTIEILRTRI 711

                         570
                  ....*....|....*....
gi 1147813   1764 LELQGLINDLQRERENLRQ 1782
Cdd:PRK01156  712 NELSDRINDINETLESMKK 730
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1624-1956 3.96e-10

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 65.53  E-value: 3.96e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1624 IVKKRSEDDLRQQRDVLDGhlREKQRTQEELRRLSSEVEalRRQLLQEQESVKQAHLRNehfQKAI-EDKSRSLNESKIE 1702
Cdd:pfam17380  277 IVQHQKAVSERQQQEKFEK--MEQERLRQEKEEKAREVE--RRRKLEEAEKARQAEMDR---QAAIyAEQERMAMERERE 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1703 IERLQsltenltkehlmLEEELRnlrleydDLRRGRSEadsdknatilelrsQLQISNNRTLELQGLINDLQRERENLRQ 1782
Cdd:pfam17380  350 LERIR------------QEERKR-------ELERIRQE--------------EIAMEISRMRELERLQMERQQKNERVRQ 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1783 EIEKFQKQaleasnRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRakstlEAEtRVKQRLECEKQQIQN 1862
Cdd:pfam17380  397 ELEAARKV------KILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAR-----EME-RVRLEEQERQQQVER 464

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1863 DLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIE-RLQAEIKriEERCRRKLEDSTRETQSQLETERSRYQREIDK 1941
Cdd:pfam17380  465 LRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEeRKQAMIE--EERKRKLLEKEMEERQKAIYEEERRREAEEER 542

                          330
                   ....*....|....*
gi 1147813    1942 LRQRPYGSHRETQTE 1956
Cdd:pfam17380  543 RKQQEMEERRRIQEQ 557
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1503-1860 4.80e-10

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 64.92  E-value: 4.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1503 ENARLQRVQYDLQKANSSATETINKLKVQ-EQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLK 1581
Cdd:pfam07888   42 ERAELLQAQEAANRQREKEKERYKRDREQwERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1582 RTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLdghlrekQRTQEELRRLSSEV 1661
Cdd:pfam07888  122 AQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKL-------QQTEEELRSLSKEF 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1662 EALRR-------QLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTkehlMLEEELRNLRLEYD-- 1732
Cdd:pfam07888  195 QELRNslaqrdtQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVE----GLGEELSSMAAQRDrt 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1733 --DLRRGRSEAdsdknatiLELRSQLQISNNRTLELQGlinDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ 1810
Cdd:pfam07888  271 qaELHQARLQA--------AQLTLQLADASLALREGRA---RWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEERM 339

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1147813    1811 ERESLLVKIKVlEQDKARLQRLED--ELNRAKSTLEAETRVKQRLECEKQQI 1860
Cdd:pfam07888  340 EREKLEVELGR-EKDCNRVQLSESrrELQELKASLRVAQKEKEQLQAEKQEL 390
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2726-2764 6.84e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 56.18  E-value: 6.84e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2726 FLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRL 2764
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1395-1916 8.08e-10

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 64.92  E-value: 8.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1395 IDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMrTEESVRYKQSL---DD 1471
Cdd:PRK01156  185 IDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSL-EDMKNRYESEIktaES 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1472 AAKTIQDKNKEI----ERLKQLIDKET-----------NDRKCLEDENARLQRVQYDLQKANSsATETINKLKVQEQELT 1536
Cdd:PRK01156  264 DLSMELEKNNYYkeleERHMKIINDPVyknrnyindyfKYKNDIENKKQILSNIDAEINKYHA-IIKKLSVLQKDYNDYI 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1537 RLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK-------LEEELEGMRRSLKEQA 1609
Cdd:PRK01156  343 KKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIqeidpdaIKKELNEINVKLQDIS 422

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1610 IKITNLTQQLEQAsivkKRSEDDLRQQRDVLDGHLR----------------------EKQRTQEELRRLSSEVEAL--- 1664
Cdd:PRK01156  423 SKVSSLNQRIRAL----RENLDELSRNMEMLNGQSVcpvcgttlgeeksnhiinhyneKKSRLEEKIREIEIEVKDIdek 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1665 RRQLLQEQESVKQAHLRN-EHFQKAIEDKSRSLNESKIEIERLQsltENLTKEHlMLEEELRNLRLEydDLRRGRSEADS 1743
Cdd:PRK01156  499 IVDLKKRKEYLESEEINKsINEYNKIESARADLEDIKIKINELK---DKHDKYE-EIKNRYKSLKLE--DLDSKRTSWLN 572

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1744 dknatILELRSQLQISNNRTL--ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNqctqvvqereSLLVKIKV 1821
Cdd:PRK01156  573 -----ALAVISLIDIETNRSRsnEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEAN----------NLNNKYNE 637

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1822 LEQDKARLQRLEDELNRAKStleaETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER 1901
Cdd:PRK01156  638 IQENKILIEKLRGKIDNYKK----QIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINE 713

                         570
                  ....*....|....*
gi 1147813   1902 LQAEIKRIEERCRRK 1916
Cdd:PRK01156  714 LSDRINDINETLESM 728
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1385-1945 8.69e-10

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 64.46  E-value: 8.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1385 EEDTSGYRAQIDNLTREN---RSLSEE----IKRLKNTLTQTTENLRRVEEDIQQQ---KATGSEVSQRKQQ-------- 1446
Cdd:pfam10174  115 EENFRRLQSEHERQAKELfllRKTLEEmelrIETQKQTLGARDESIKKLLEMLQSKglpKKSGEEDWERTRRiaeaemql 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1447 --LEVELRQV---TQMRTEESVRYKQSLDDAAKT------IQDKNKEIERLkqlidkETNDRKcLEDEnarLQRVQYDLQ 1515
Cdd:pfam10174  195 ghLEVLLDQKekeNIHLREELHRRNQLQPDPAKTkalqtvIEMKDTKISSL------ERNIRD-LEDE---VQMLKTNGL 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1516 KANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLE 1595
Cdd:pfam10174  265 LHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAAILQ 344

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1596 EELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESV 1675
Cdd:pfam10174  345 TEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERV 424

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1676 KQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHL----MLEEELRNLRLEYDDLRRGRSEadsdKNATILE 1751
Cdd:pfam10174  425 KSLQTDSSNTDTALTTLEEALSEKERIIERLKEQREREDRERLeeleSLKKENKDLKEKVSALQPELTE----KESSLID 500

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1752 LRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEAsnriqeskNQCTQVVQERESLLVKIKVLEQDkarLQR 1831
Cdd:pfam10174  501 LKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKA--------HNAEEAVRTNPEINDRIRLLEQE---VAR 569

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1832 LEDELNRAKSTLEAETRVKQRLECEKqqiqndlnqwktqySRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR--- 1908
Cdd:pfam10174  570 YKEESGKAQAEVERLLGILREVENEK--------------NDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKKkga 635

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 1147813    1909 --IEERCRRKLEDSTRETQSQLE---TERSRYQREIDKLRQR 1945
Cdd:pfam10174  636 qlLEEARRREDNLADNSQQLQLEelmGALEKTRQELDATKAR 677
PLEC smart00250
Plectin repeat;
2648-2685 1.07e-09

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 55.57  E-value: 1.07e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2648 QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2685
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1720-1916 1.27e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 62.86  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1720 LEEELRNLRLEYDDLRRGRSEADSDKNAtileLRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQ 1799
Cdd:COG4942   25 AEAELEQLQQEIAELEKELAALKKEEKA----LLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1800 ESKNQCTQVV--------QERESLLVKIK--------------VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEK 1857
Cdd:COG4942  101 AQKEELAELLralyrlgrQPPLALLLSPEdfldavrrlqylkyLAPARREQAEELRADLAELAALRAELEAERAELEALL 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813  1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRK 1916
Cdd:COG4942  181 AELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1562-1835 1.47e-09

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 61.85  E-value: 1.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1562 SLKELQLQKQKVEEELNRLKRtasedscKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDvld 1641
Cdd:COG1340    9 SLEELEEKIEELREEIEELKE-------KRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKE--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1642 ghlrEKQRTQEELRRLSSEVEALRRQLLQEQ---ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENL--TKE 1716
Cdd:COG1340   79 ----ERDELNEKLNELREELDELRKELAELNkagGSIDKLRKEIERLEWRQQTEVLSPEEEKELVEKIKELEKELekAKK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1717 HLMLEEELRNLRLEYDDLRRGRSEAdsdkNATILELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQKQALEASN 1796
Cdd:COG1340  155 ALEKNEKLKELRAELKELRKEAEEI----HKKIKELAEEAQ-------ELHEEMIELYKEADELRKEADELHKEIVEAQE 223

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 1147813  1797 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDE 1835
Cdd:COG1340  224 KADELHEEIIELQKELRELRKELKKLRKKQRALKREKEK 262
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1102-1501 1.92e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 63.22  E-value: 1.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1102 GQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKE---YEIERLRVLL 1178
Cdd:pfam17380  240 KESFNLAEDVTTMTPEYTVRYNGQTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKMEQERLRQEKEekaREVERRRKLE 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1179 QEEGTRKREYENELAKVRNHynEEMSNLRNKYETEINitkttikeismQKEDDSKNLRNQLDRLSRENRDLKdEIVRLND 1258
Cdd:pfam17380  320 EAEKARQAEMDRQAAIYAEQ--ERMAMERERELERIR-----------QEERKRELERIRQEEIAMEISRMR-ELERLQM 385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1259 SILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEaaktiqDKNKEIERLKaefQEEA 1338
Cdd:pfam17380  386 ERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEE------ERAREMERVR---LEEQ 456

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1339 KRRWEYEnelskvRNNYDEEIISLKnqfeteinitkttihQLTMQKEEDTsgyRAQIDNLTRenRSLSEEIKRLKNTLTQ 1418
Cdd:pfam17380  457 ERQQQVE------RLRQQEEERKRK---------------KLELEKEKRD---RKRAEEQRR--KILEKELEERKQAMIE 510

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1419 TTENLRRVEEDIQQQKATGSEVSQRKqqlEVELRQVTQMRTEESVRYKQSLDDAAKT---IQDKNKEIERLKQLIDKEtN 1495
Cdd:pfam17380  511 EERKRKLLEKEMEERQKAIYEEERRR---EAEEERRKQQEMEERRRIQEQMRKATEErsrLEAMEREREMMRQIVESE-K 586


                   ....*.
gi 1147813    1496 DRKCLE 1501
Cdd:pfam17380  587 ARAEYE 592
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1557-1912 1.92e-09

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 62.99  E-value: 1.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1557 TRFQNSLKE----LQLQ---KQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASivkkRS 1629
Cdd:pfam07888   34 NRLEECLQEraelLQAQeaaNRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELS----AS 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1630 EDDLRQQRDVL-------DGHLRE--------KQRTQE---ELRRLSSEVEALRRQLLQEQESVKQAHLRNEhfqkAIED 1691
Cdd:pfam07888  110 SEELSEEKDALlaqraahEARIREleediktlTQRVLEretELERMKERAKKAGAQRKEEEAERKQLQAKLQ----QTEE 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1692 KSRSLNEskiEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNaTILELRSQLQISNNRTLELQGLIN 1771
Cdd:pfam07888  186 ELRSLSK---EFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLE-ELRSLQERLNASERKVEGLGEELS 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1772 DLQRERENLRQEIEKFQKQALEASNRIQES----KNQCTQVVQERESLLvkiKVLEQDKARLQRLEDELNRAKSTLEAET 1847
Cdd:pfam07888  262 SMAAQRDRTQAELHQARLQAAQLTLQLADAslalREGRARWAQERETLQ---QSAEADKDRIEKLSAELQRLEERLQEER 338

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1147813    1848 RVKQRLECEKQQiQNDLNQWKTQYSRKEeaIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1912
Cdd:pfam07888  339 MEREKLEVELGR-EKDCNRVQLSESRRE--LQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQR 400
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1706-1945 2.60e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.40  E-value: 2.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1706 LQSLTEnLTKEHlMLEE-----ELRNLRLEYDDLRRGRSEadsdknatILELRSQLqisnnRTLELqglINDLQRERENL 1780
Cdd:COG4913  206 IGDLDD-FVREY-MLEEpdtfeAADALVEHFDDLERAHEA--------LEDAREQI-----ELLEP---IRELAERYAAA 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1781 RQEIEKFQK-----QALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKstLEAETRVKQRLEC 1855
Cdd:COG4913  268 RERLAELEYlraalRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQI--RGNGGDRLEQLER 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1856 EKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLeDSTRETQSQLETERSRY 1935
Cdd:COG4913  346 EIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEAL-AEAEAALRDLRRELREL 424

                        250
                 ....*....|
gi 1147813  1936 QREIDKLRQR 1945
Cdd:COG4913  425 EAEIASLERR 434
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 880-1614 2.82e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 63.07  E-value: 2.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     880 DLEKQIKQLRNYRDNYQAfckwlyDRKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIK 959
Cdd:pfam02463  294 EEEELKSELLKLERRKVD------DEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEK 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     960 DYELQ---LASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARY----IELLTRSGDYYRFLSEMLKSLEDLKLKNT 1032
Cdd:pfam02463  368 LEQLEeelLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELArqleDLLKEEKKEELEILEEEEESIELKQGKLT 447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1033 KIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN---E 1109
Cdd:pfam02463  448 EEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRiisA 527

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1110 KITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYE 1189
Cdd:pfam02463  528 HGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQ 607

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1190 NELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQkEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR 1269
Cdd:pfam02463  608 LDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKE-SGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAE 686

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1270 AEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI----QDKNKEIERLKAEFQEEAKRRWEYE 1345
Cdd:pfam02463  687 SELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEElkllKQKIDEEEEEEEKSRLKKEEKEEEK 766

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1346 NELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTT----- 1420
Cdd:pfam02463  767 SELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALElkeeq 846

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1421 -------ENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKE 1493
Cdd:pfam02463  847 kleklaeEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEE 926

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1494 TNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQEltrlridyeRVSQERTVKDQDITRFqnslKELQLQKQKV 1573
Cdd:pfam02463  927 AEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLL---------AKEELGKVNLMAIEEF----EEKEERYNKD 993

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|.
gi 1147813    1574 EEELNRLKRtasedscKRKKLEEELEGMRRSLKEQAIKITN 1614
Cdd:pfam02463  994 ELEKERLEE-------EKKKLIRAIIEETCQRLKEFLELFV 1027
PTZ00121 PTZ00121
MAEBL; Provisional
 779-1553 3.36e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.24  E-value: 3.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    779 QTEDMLKVYEARLTEEETVCLDLDKVEAYRcGLKKIKNDLNLKKSLLATMKTELQKAQQIHsqtsqqyplydldlgkfge 858
Cdd:PTZ00121 1135 KAEDARKAEEARKAEDAKRVEIARKAEDAR-KAEEARKAEDAKKAEAARKAEEVRKAEELR------------------- 1194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    859 kvtqltdRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQA-FCKWLYDRKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
Cdd:PTZ00121 1195 -------KAEDARKAEAARKAEEERKAEEARKAEDAKKAeAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFAR 1267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    938 SGKRDKSEEVQKIAEL--CANSIKDYELQLASYTSGLETLlnipiKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYR 1015
Cdd:PTZ00121 1268 RQAAIKAEEARKADELkkAEEKKKADEAKKAEEKKKADEA-----KKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAK 1342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1016 FLSEMLKSLEDLKLKntKIEVLEEELRLARDANSEncnknkfldqnlQKYQAECSQFKA-KLASLEELKRQAELDGKSAK 1094
Cdd:PTZ00121 1343 KAAEAAKAEAEAAAD--EAEAAEEKAEAAEKKKEE------------AKKKADAAKKKAeEKKKADEAKKKAEEDKKKAD 1408

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1095 QnLDKCYGQIKELNEKITRltyeiEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEK-ENLGWQKLESEKAIKEKEyeier 1173
Cdd:PTZ00121 1409 E-LKKAAAAKKKADEAKKK-----AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKaEEAKKKAEEAKKADEAKK----- 1477

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1174 lrvllQEEGTRKREyenELAKVRNHYNEEMSNLRNKYEteiniTKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEI 1253
Cdd:PTZ00121 1478 -----KAEEAKKAD---EAKKKAEEAKKKADEAKKAAE-----AKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEE 1544

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1254 VRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSlEEAAKTIQDKNKEIERLKAe 1333
Cdd:PTZ00121 1545 KKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEE-EKKMKAEEAKKAEEAKIKA- 1622

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1334 fqEEAKRRWEYENELSKVRNNYDEEIISLKNqfeteinitkttihqltMQKEEDTSGYRAQidnltrENRSLSEEIKRLK 1413
Cdd:PTZ00121 1623 --EELKKAEEEKKKVEQLKKKEAEEKKKAEE-----------------LKKAEEENKIKAA------EEAKKAEEDKKKA 1677

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1414 NTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRyKQSLDDAAKTIQDKNKEIERLKqlidKE 1493
Cdd:PTZ00121 1678 EEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEEN-KIKAEEAKKEAEEDKKKAEEAK----KD 1752

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1494 TNDRKCLedenARLQRVQYDLQKANSSATETINKLKVQEQELTRlridyeRVSQERTVKD 1553
Cdd:PTZ00121 1753 EEEKKKI----AHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKR------RMEVDKKIKD 1802
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1441-1681 4.08e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.32  E-value: 4.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1441 SQRKQQLEVELRQVTQMRTEEsvryKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRvqyDLQKANSS 1520
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAEL----EKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEA---ELAELEKE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1521 ATETINKLKVQEQEL-TRLRIDYERVSQERT---VKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEE 1596
Cdd:COG4942   92 IAELRAELEAQKEELaELLRALYRLGRQPPLallLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1597 ELEGMRRSLKEQAIKITNLTQQLEQasivKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVK 1676
Cdd:COG4942  172 ERAELEALLAELEEERAALEALKAE----RQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247


                 ....*
gi 1147813  1677 QAHLR 1681
Cdd:COG4942  248 FAALK 252
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1303-1492 5.40e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.93  E-value: 5.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1303 SEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVR---NNYDEEIislkNQFETEINITKTTIHQ 1379
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALArriRALEQEL----AALEAELAELEKEIAE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1380 LTMQKEEDTSGYRAQIDNLTRENR------------------------SLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA 1435
Cdd:COG4942   95 LRAELEAQKEELAELLRALYRLGRqpplalllspedfldavrrlqylkYLAPARREQAEELRADLAELAALRAELEAERA 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813  1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDK 1492
Cdd:COG4942  175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1057-1582 6.53e-09

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 61.84  E-value: 6.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1057 FLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQK 1136
Cdd:PRK01156  187 YLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTAESDLS 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1137 NDYDQLQKARQCEKEnlgWQKLESEKAIKEKEY---------EIERLRVLLQEEGTRKREYENELAKVrnhynEEMSNLR 1207
Cdd:PRK01156  267 MELEKNNYYKELEER---HMKIINDPVYKNRNYindyfkyknDIENKKQILSNIDAEINKYHAIIKKL-----SVLQKDY 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1208 NKYETEINITKTTIKEISMQKEDDSK--NLRNQLDRLSRENRDLKDEIVRLNDSIlqaTEQRRRAEENALQQKACGSEIM 1285
Cdd:PRK01156  339 NDYIKKKSRYDDLNNQILELEGYEMDynSYLKSIESLKKKIEEYSKNIERMSAFI---SEILKIQEIDPDAIKKELNEIN 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1286 QKKQHLEIELKQvMQQRSEDNARHKQSLEEAAKTIQDKNK-----------EIERLKAEFQEEAKRRWEYENELSKVRNN 1354
Cdd:PRK01156  416 VKLQDISSKVSS-LNQRIRALRENLDELSRNMEMLNGQSVcpvcgttlgeeKSNHIINHYNEKKSRLEEKIREIEIEVKD 494

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1355 YDEEIISLK-----------NQFETEINITKTTIHQLT--MQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNT-----L 1416
Cdd:PRK01156  495 IDEKIVDLKkrkeyleseeiNKSINEYNKIESARADLEdiKIKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTswlnaL 574

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1417 TQTT----ENLRRVEEDIQQQKatgSEVSQRKQQLEVELRQVTQMrTEESVRykqSLDDAAKTIQDKNKEIERLKQLIDK 1492
Cdd:PRK01156  575 AVISlidiETNRSRSNEIKKQL---NDLESRLQEIEIGFPDDKSY-IDKSIR---EIENEANNLNNKYNEIQENKILIEK 647

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1493 ETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQL---Q 1569
Cdd:PRK01156  648 LRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINEtleS 727

                         570
                  ....*....|...
gi 1147813   1570 KQKVEEELNRLKR 1582
Cdd:PRK01156  728 MKKIKKAIGDLKR 740
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1227-1879 6.74e-09

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 61.89  E-value: 6.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1227 QKEDDSKNLRNQLDRLSRENRDLKDEIVRlNDSILQATEQRRRAEEnalqQKAcgseIMQKKQHLEIELKQvMQQRSEDN 1306
Cdd:COG3096  462 QKLSVADAARRQFEKAYELVCKIAGEVER-SQAWQTARELLRRYRS----QQA----LAQRLQQLRAQLAE-LEQRLRQQ 531

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1307 ARHKQSLEEAAKTIQ---DKNKEIERLKAEFQEEAKRRWEYENELSKVRNnydeeiislknQFETEINITKTTIHQLTMQ 1383
Cdd:COG3096  532 QNAERLLEEFCQRIGqqlDAAEELEELLAELEAQLEELEEQAAEAVEQRS-----------ELRQQLEQLRARIKELAAR 600

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1384 KEEdtsgYRAQIDNLTRenrsLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESV 1463
Cdd:COG3096  601 APA----WLAAQDALER----LREQSGEALADSQEVTAAMQQLLEREREATVERDELAARKQALESQIERLSQPGGAEDP 672

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1464 RYKQ-----------------SLDDA------------AKTIQDKNKEIERLKQLIDketndrkCLEDenarLQRVQYDL 1514
Cdd:COG3096  673 RLLAlaerlggvllseiyddvTLEDApyfsalygparhAIVVPDLSAVKEQLAGLED-------CPED----LYLIEGDP 741

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1515 QKANSSAtetinkLKVQEQELTRLRIDYERvsQERTVKDQDITRFQNSLKELQLQKQKVE-EELNRLKRTASEDSCKRKK 1593
Cdd:COG3096  742 DSFDDSV------FDAEELEDAVVVKLSDR--QWRYSRFPEVPLFGRAAREKRLEELRAErDELAEQYAKASFDVQKLQR 813

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1594 LEEELEGMrrslkeqaikitnLTQQLEQASIVKKRSE-DDLRQQRDVLDGHLrekQRTQEELRRLSSEVEALRRQLLQEQ 1672
Cdd:COG3096  814 LHQAFSQF-------------VGGHLAVAFAPDPEAElAALRQRRSELEREL---AQHRAQEQQLRQQLDQLKEQLQLLN 877

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1673 ESVKQAH-LRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKehlmLEEELRNLR---LEYDDLRRGRSEADSDKNat 1748
Cdd:COG3096  878 KLLPQANlLADETLADRLEELREELDAAQEAQAFIQQHGKALAQ----LEPLVAVLQsdpEQFEQLQADYLQAKEQQR-- 951

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1749 ilELRSQL----QISNNRT----LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLlvkiK 1820
Cdd:COG3096  952 --RLKQQIfalsEVVQRRPhfsyEDAVGLLGENSDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASL----K 1025

                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1147813  1821 VLEQDKAR-LQRLEDELN----RAKSTLEAETRV-KQRLECEKQQIQNDLNQWKTQYSRKEEAIR 1879
Cdd:COG3096 1026 SSRDAKQQtLQELEQELEelgvQADAEAEERARIrRDELHEELSQNRSRRSQLEKQLTRCEAEMD 1090
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1165-1631 8.07e-09

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 61.13  E-value: 8.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1165 KEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDsKNLRNQLDRLSR 1244
Cdd:COG5185   78 KSESSVKARKFLKEKKLDTKILQEYVNSLIKLPNYEWSADILISLLYLYKSEIVALKDELIKVEKLD-EIADIEASYGEV 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1245 ENRDLKDEIVRLNDSILQATEQRRRAEENALQQKAC------GSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAK 1318
Cdd:COG5185  157 ETGIIKDIFGKLTQELNQNLKKLEIFGLTLGLLKGIselkkaEPSGTVNSIKESETGNLGSESTLLEKAKEIINIEEALK 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1319 TIQDKNKEIERLKAefqeeakrrweYENELSKV---RNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQI 1395
Cdd:COG5185  237 GFQDPESELEDLAQ-----------TSDKLEKLveqNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSI 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1396 DnLTRENRSLSEEIKRLKnTLTQTTENLRRVEEDIQQQKAtgsEVSQRKQQLEVELRQVTQMRteESVRYKQSLDDAAKT 1475
Cdd:COG5185  306 D-IKKATESLEEQLAAAE-AEQELEESKRETETGIQNLTA---EIEQGQESLTENLEAIKEEI--ENIVGEVELSKSSEE 378

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1476 IQDKNKEIERLKQLIDKETNDRKCLEDENA------------RLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYE 1543
Cdd:COG5185  379 LDSFKDTIESTKESLDEIPQNQRGYAQEILatledtlkaadrQIEELQRQIEQATSSNEEVSKLLNELISELNKVMREAD 458

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1544 RVSQERTVKDQD--ITRFQNSLKELQLQKQKVEEELNRLKRTASEDsckRKKLEEELEGMRRSLKEQAIKITNLTQQLEQ 1621
Cdd:COG5185  459 EESQSRLEEAYDeiNRSVRSKKEDLNEELTQIESRVSTLKATLEKL---RAKLERQLEGVRSKLDQVAESLKDFMRARGY 535

                        490
                 ....*....|
gi 1147813  1622 ASIVKKRSED 1631
Cdd:COG5185  536 AHILALENLI 545
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1491-1716 1.06e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.16  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1491 DKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQK 1570
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1571 QKVEEELNRLKRTASedscKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQAsivKKRSEDDLRQQRDVLDGHLREKQRT 1650
Cdd:COG4942  100 EAQKEELAELLRALY----RLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPA---RREQAEELRADLAELAALRAELEAE 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1147813  1651 QEELRRLSSEVEALRRQLLQEQESVKQAHLRnehFQKAIEDKSRSLNESKIEIERLQSLTENLTKE 1716
Cdd:COG4942  173 RAELEALLAELEEERAALEALKAERQKLLAR---LEKELAELAAELAELQQEAEELEALIARLEAE 235
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1475-1678 1.23e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 60.80  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1475 TIQDKNKEIERLKQLIDKETND-RKCLEDENARLQ--RVQYDLQKANSSATETINKLKVQEQELTRLRID-------YER 1544
Cdd:COG3206  165 NLELRREEARKALEFLEEQLPElRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAElaeaearLAA 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1545 VSQERTVKDQDITRFQNS--LKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI-TNLTQQLEQ 1621
Cdd:COG3206  245 LRAQLGSGPDALPELLQSpvIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRIlASLEAELEA 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1622 AsivkKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRR---QLLQEQESVKQA 1678
Cdd:COG3206  325 L----QAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARElyeSLLQRLEEARLA 380
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1005-1335 1.31e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.84  E-value: 1.31e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1005 ELLTRSGDYYRFLSEMLKSLEDLKlknTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR 1084
Cdd:TIGR02168  716 QLRKELEELSRQISALRKDLARLE---AEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIE 792

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1085 QAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNdydqlqkarqcEKENLGWQKLESEKAI 1164
Cdd:TIGR02168  793 QLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE-----------QIEELSEDIESLAAEI 861

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1165 KEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRN------KYETEINITKTTIKEISMQKEDDSKNLRNQ 1238
Cdd:TIGR02168  862 EELEELIEELESELEALLNERASLEEALALLRSELEELSEELREleskrsELRRELEELREKLAQLELRLEGLEVRIDNL 941

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1239 LDRLSRENRDLKDEIVRLNDSI-LQATEQRRRAEENALQQKACG-------SEIMQKKQHLEIELKQvmqqrSEDNARHK 1310
Cdd:TIGR02168  942 QERLSEEYSLTLEEAEALENKIeDDEEEARRRLKRLENKIKELGpvnlaaiEEYEELKERYDFLTAQ-----KEDLTEAK 1016

                          330       340
                   ....*....|....*....|....*.
gi 1147813    1311 QSLEEAaktIQDKNKEI-ERLKAEFQ 1335
Cdd:TIGR02168 1017 ETLEEA---IEEIDREArERFKDTFD 1039
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1646-1880 1.97e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.39  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1646 EKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELR 1725
Cdd:COG4942   21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1726 NLRLEYDDLrrgrseadsdknatileLRSQLQISNNRTLEL---QGLINDLQRERENLRQEIEKFQKQALEASNRIQESK 1802
Cdd:COG4942  101 AQKEELAEL-----------------LRALYRLGRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELA 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813  1803 NQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRK 1880
Cdd:COG4942  164 ALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 855-1805 2.19e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 60.45  E-value: 2.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     855 KFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWL---YDRKRRQDSLESMKFGDSNTVMRF----- 926
Cdd:TIGR01612 1108 KYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLedvADKAISNDDPEEIEKKIENIVTKIdkkkn 1187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     927 -LNEQKNLHSEISG-KRDKS--EEVQKIAELCANSI------------KDYELQLASYTSGLETLLNIPIKRTMIQSPSG 990
Cdd:TIGR01612 1188 iYDEIKKLLNEIAEiEKDKTslEEVKGINLSYGKNLgklflekideekKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMG 1267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     991 VILQEAADVHARYIELlTRSGDYYRFLSEMLKSLEDLKLKNTKI-----------EVLEEELRLARDANSENCNKNKFLD 1059
Cdd:TIGR01612 1268 IEMDIKAEMETFNISH-DDDKDHHIISKKHDENISDIREKSLKIiedfseesdinDIKKELQKNLLDAQKHNSDINLYLN 1346

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1060 Q-----------NLQKYQAECSQFKAKL------------------------ASLEELKRQAE--LDGK----------- 1091
Cdd:TIGR01612 1347 EianiynilklnKIKKIIDEVKEYTKEIeennknikdeldkseklikkikddINLEECKSKIEstLDDKdidecikkike 1426

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1092 ------SAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSV-EDRFDQQKNDYD--------QLQKARQCEKENLGWQ 1156
Cdd:TIGR01612 1427 lknhilSEESNIDTYFKNADENNENVLLLFKNIEMADNKSQHIlKIKKDNATNDHDfninelkeHIDKSKGCKDEADKNA 1506

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1157 KLESEKAIKEKEYEIErLRVLLQEegTRKREYENELAKVRNHYNE---EMSNLRNKYETEINITKTTIKEISMQK---ED 1230
Cdd:TIGR01612 1507 KAIEKNKELFEQYKKD-VTELLNK--YSALAIKNKFAKTKKDSEIiikEIKDAHKKFILEAEKSEQKIKEIKKEKfriED 1583

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1231 DSKNLrnqlDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKAcgseIMQKKQHLEIELKQVMQQRSEDNArhk 1310
Cdd:TIGR01612 1584 DAAKN----DKSNKAAIDIQLSLENFENKFLKISDIKKKINDCLKETES----IEKKISSFSIDSQDTELKENGDNL--- 1652

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1311 QSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD--------EEIISLKNQFETEINITKTTIHQLTM 1382
Cdd:TIGR01612 1653 NSLQEFLESLKDQKKNIEDKKKELDELDSEIEKIEIDVDQHKKNYEigiiekikEIAIANKEEIESIKELIEPTIENLIS 1732

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1383 Q-KEEDTSGYRAQiDNLTRENRSLS---EEIKRLKNTLTQTTENLRRveEDIQQQKATGSEVSQRKQQLEVelrqvtqmr 1458
Cdd:TIGR01612 1733 SfNTNDLEGIDPN-EKLEEYNTEIGdiyEEFIELYNIIAGCLETVSK--EPITYDEIKNTRINAQNEFLKI--------- 1800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1459 TEESVRYKQSLDDAaktiqdKNKEIERLKqlidkeTNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQE---- 1534
Cdd:TIGR01612 1801 IEIEKKSKSYLDDI------EAKEFDRII------NHFKKKLDHVNDKFTKEYSKINEGFDDISKSIENVKNSTDEnllf 1868

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1535 --LTRLRIDYERVSQER--TVKDQDITRFQNSLK---ELQLQKQKvEEELNRLKRT-----ASEDSCKRKKLEEELEGMR 1602
Cdd:TIGR01612 1869 diLNKTKDAYAGIIGKKyySYKDEAEKIFINISKlanSINIQIQN-NSGIDLFDNIniailSSLDSEKEDTLKFIPSPEK 1947

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1603 RSlkEQAIKITNLTQQLEQasiVKKRSEDDLRQQRDVL-----DGHLREKQRTQEELRRLSSEVEALRRQLLQE------ 1671
Cdd:TIGR01612 1948 EP--EIYTKIRDSYDTLLD---IFKKSQDLHKKEQDTLniifeNQQLYEKIQASNELKDTLSDLKYKKEKILNDvklllh 2022

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1672 -QESVKQAHLRNEHFQKAIEdkSRSLNESKIEIERLQSLTENLTKEH--LMLEEELRNLRLEYDDLRRGRSEADSDKNAT 1748
Cdd:TIGR01612 2023 kFDELNKLSCDSQNYDTILE--LSKQDKIKEKIDNYEKEKEKFGIDFdvKAMEEKFDNDIKDIEKFENNYKHSEKDNHDF 2100

                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1749 ILELRSQLQiSNNRTLELQGLINdlqrerenlrQEIEKFQKQALEAS---NRIQESKNQC 1805
Cdd:TIGR01612 2101 SEEKDNIIQ-SKKKLKELTEAFN----------TEIKIIEDKIIEKNdliDKLIEMRKEC 2149
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1025-1674 2.35e-08

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 59.84  E-value: 2.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1025 EDLKLKNTKIEVLEEELRLARDANS-------------ENCNKNKFL-DQNLQKYQAECSQFKAKLASLEELKRQAELDG 1090
Cdd:pfam10174   67 EENQHLQLTIQALQDELRAQRDLNQllqqdfttspvdgEDKFSTPELtEENFRRLQSEHERQAKELFLLRKTLEEMELRI 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1091 KSAKQNLDKCYGQIKELNEKI------TRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI 1164
Cdd:pfam10174  147 ETQKQTLGARDESIKKLLEMLqskglpKKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLREELHRRNQLQPDPA 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1165 KEKEY----EIERLRVLLQEEGTRKREYENELAKVR-----NHYNEEMSNLRnKYETEINITKTTIKEISMQ---KEDDS 1232
Cdd:pfam10174  227 KTKALqtviEMKDTKISSLERNIRDLEDEVQMLKTNgllhtEDREEEIKQME-VYKSHSKFMKNKIDQLKQElskKESEL 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1233 KNLRNQLDRLSRENRDLKDEIVRLNDSiLQATEQRR---RAEENALQQKACGSE-IMQKKQHleiELKQVMQQRSEDNA- 1307
Cdd:pfam10174  306 LALQTKLETLTNQNSDCKQHIEVLKES-LTAKEQRAailQTEVDALRLRLEEKEsFLNKKTK---QLQDLTEEKSTLAGe 381

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1308 -RH-KQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYEN---ELSKVRNNYDEEIISLknqfETEINITKTTIHQLTM 1382
Cdd:pfam10174  382 iRDlKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKErvkSLQTDSSNTDTALTTL----EEALSEKERIIERLKE 457

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1383 QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQ--MRTE 1460
Cdd:pfam10174  458 QREREDRERLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEecSKLE 537

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1461 ESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKV----QEQELT 1536
Cdd:pfam10174  538 NQLKKAHNAEEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESltlrQMKEQN 617

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1537 RLRIDYERVSQERTVK----DQDITRFQNSLKELQLQKQkVEEELNRLKRTASE-DSCKRKkleeeLEGMRRSLKEQAIK 1611
Cdd:pfam10174  618 KKVANIKHGQQEMKKKgaqlLEEARRREDNLADNSQQLQ-LEELMGALEKTRQElDATKAR-----LSSTQQSLAEKDGH 691

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1147813    1612 ITNLTQ----QLEQASIVKKR------SEDDlrQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQES 1674
Cdd:pfam10174  692 LTNLRAerrkQLEEILEMKQEallaaiSEKD--ANIALLELSSSKKKKTQEEVMALKREKDRLVHQLKQQTQN 762
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1336-1677 2.84e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 59.75  E-value: 2.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1336 EEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKeedTSGYRAQIDNLTRENRslsEEIKRLKNT 1415
Cdd:pfam17380  234 EKMERRKESFNLAEDVTTMTPEYTVRYNGQTMTENEFLNQLLHIVQHQK---AVSERQQQEKFEKMEQ---ERLRQEKEE 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1416 LTQTTENLRRVEE-------DIQQQKATGSEvsQRKQQLEVElRQVTQMRTEESVRYKQSLDDAAKTIQ-DKNKEIERLk 1487
Cdd:pfam17380  308 KAREVERRRKLEEaekarqaEMDRQAAIYAE--QERMAMERE-RELERIRQEERKRELERIRQEEIAMEiSRMRELERL- 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1488 QLIDKETNDRKCLEDENARLQRVQ-YDLQKANSSATETINKLKVQEQELTRLRI---------DYERVSQERTVKDQDIT 1557
Cdd:pfam17380  384 QMERQQKNERVRQELEAARKVKILeEERQRKIQQQKVEMEQIRAEQEEARQREVrrleeerarEMERVRLEEQERQQQVE 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1558 RFQNS-----LKELQLQKQKVE----EELNrlkrtasedsckRKKLEEELEGMRRSLKEQAIKITNLTQQLE--QASIV- 1625
Cdd:pfam17380  464 RLRQQeeerkRKKLELEKEKRDrkraEEQR------------RKILEKELEERKQAMIEEERKRKLLEKEMEerQKAIYe 531

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1147813    1626 ---KKRSEDDLRQQRDvldghLREKQRTQEELRRLSSE---VEALRRQ---LLQEQESVKQ 1677
Cdd:pfam17380  532 eerRREAEEERRKQQE-----MEERRRIQEQMRKATEErsrLEAMEREremMRQIVESEKA 587
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1717-1912 3.07e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.40  E-value: 3.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1717 HLMLEEELRNlrlEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQR---ERENLRQEIEKFQK--QA 1791
Cdd:COG4717   44 RAMLLERLEK---EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEEleeELEELEAELEELREelEK 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1792 LEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTL-EAETRVKQRLECEKQQIQNDLNQWKTQ 1870
Cdd:COG4717  121 LEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELaELQEELEELLEQLSLATEEELQDLAEE 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 1147813  1871 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1912
Cdd:COG4717  201 LEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE 242
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 1233-1944 3.36e-08

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 59.43  E-value: 3.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1233 KNLRNQLDRLSRenrdlKDEIVRLNDSILQATEQRRRAEENALQQKACGS---------EIMQKKQHLEIELKQVMQQRS 1303
Cdd:PRK10246  240 QQQQQSLNWLTR-----LDELQQEASRRQQALQQALAAEEKAQPQLAALSlaqparqlrPHWERIQEQSAALAHTRQQIE 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAkrRWEYENELSKVRNNydeEIISLKNQFeTEINITKTTIHQLTMQ 1383
Cdd:PRK10246  315 EVNTRLQSTMALRARIRHHAAKQSAELQAQQQSLN--TWLAEHDRFRQWNN---ELAGWRAQF-SQQTSDREQLRQWQQQ 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1384 KEEDtsgyRAQIDNLTRENRSLSEEikRLKNTLTQTTEnlrrvEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESV 1463
Cdd:PRK10246  389 LTHA----EQKLNALPAITLTLTAD--EVAAALAQHAE-----QRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQT 457

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1464 RYKQSLDDAAKTIQDKNKEIERLKQLIDKETNdRKCLEDENARLQRVQYDLQKANSS--ATETINKLKVQEQELTRLRID 1541
Cdd:PRK10246  458 QRNAALNEMRQRYKEKTQQLADVKTICEQEAR-IKDLEAQRAQLQAGQPCPLCGSTShpAVEAYQALEPGVNQSRLDALE 536

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1542 YERvsqeRTVKDQDITrFQNSLKELQLQKQKVEEELNRLkrtasedsckrkkLEEelegmrrslkEQAikITNLTQQLEQ 1621
Cdd:PRK10246  537 KEV----KKLGEEGAA-LRGQLDALTKQLQRDESEAQSL-------------RQE----------EQA--LTQQWQAVCA 586

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1622 ASIVKKRSEDDLRqqrdvldGHLREKQRTQEELRRLSsevealRRQLLQEQESVKQAHLRneHFQKAIEdksrslneski 1701
Cdd:PRK10246  587 SLNITLQPQDDIQ-------PWLDAQEEHERQLRLLS------QRHELQGQIAAHNQQII--QYQQQIE----------- 640

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1702 eiERLQSLTENLTKEHLMLEEElrnlrleyddlrrgrseadsDKNATILELRSQ----LQISNNRTLELQGLINDLQRER 1777
Cdd:PRK10246  641 --QRQQQLLTALAGYALTLPQE--------------------DEEASWLATRQQeaqsWQQRQNELTALQNRIQQLTPLL 698

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1778 ENLRQEIEKFQKQALEASNRIQESKNQC-----------TQVVQERESLLvkiKVLEQDKARLQ--RLEDELNRAKSTLE 1844
Cdd:PRK10246  699 ETLPQSDDLPHSEETVALDNWRQVHEQClslhsqlqtlqQQDVLEAQRLQ---KAQAQFDTALQasVFDDQQAFLAALLD 775

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1845 AETRvkQRLECEKQQIQNDLNQWKTQYSRKEEAIrkieSEREKSEREKNSLRSEIERLQAEIKRIEERCRrklEDSTR-- 1922
Cdd:PRK10246  776 EETL--TQLEQLKQNLENQRQQAQTLVTQTAQAL----AQHQQHRPDGLDLTVTVEQIQQELAQLAQQLR---ENTTRqg 846

                         730       740
                  ....*....|....*....|....*...
gi 1147813   1923 ETQSQL-ETERSRYQ-----REIDKLRQ 1944
Cdd:PRK10246  847 EIRQQLkQDADNRQQqqalmQQIAQATQ 874
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1316-1563 3.51e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 58.24  E-value: 3.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1316 AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYdeeiislkNQFETEINITKTTIHQLtmqkEEDTSGYRAQI 1395
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQL--------AALERRIAALARRIRAL----EQELAALEAEL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1396 DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT 1475
Cdd:COG4942   86 AELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1476 IQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRL--RIDYERVSQERTVKD 1553
Cdd:COG4942  166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALiaRLEAEAAAAAERTPA 245

                        250
                 ....*....|
gi 1147813  1554 QDITRFQNSL 1563
Cdd:COG4942  246 AGFAALKGKL 255
PRK11281 PRK11281
mechanosensitive channel MscK;
1288-1672 3.86e-08

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 59.54  E-value: 3.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1288 KQHLE--IELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW------EYENELSKVRNN----- 1354
Cdd:PRK11281   62 QQDLEqtLALLDKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLstlslrQLESRLAQTLDQlqnaq 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1355 -----YDEEIISLKNQFE---TEINITKTTIHQLTMQKEEDTSGYRA----QIDNLTRENRSLSEEIKRLK-----NTLT 1417
Cdd:PRK11281  142 ndlaeYNSQLVSLQTQPEraqAALYANSQRLQQIRNLLKGGKVGGKAlrpsQRVLLQAEQALLNAQNDLQRkslegNTQL 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1418 QTTENLRRveediqqqkatgSEVSQRKQQLEVEL---------RQVTQmrTEESVRYKQSLDDAAKTIQDknkeierlkQ 1488
Cdd:PRK11281  222 QDLLQKQR------------DYLTARIQRLEHQLqllqeainsKRLTL--SEKTVQEAQSQDEAARIQAN---------P 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1489 LIDKETndrkcleDENARLQrvQYDLQkanssATETINKLkVQEQELTRLRIDyeRVSQ-ERTVKDQdITRFQNSL---K 1564
Cdd:PRK11281  279 LVAQEL-------EINLQLS--QRLLK-----ATEKLNTL-TQQNLRVKNWLD--RLTQsERNIKEQ-ISVLKGSLllsR 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1565 ELQLQKQKV--EEELNRL-KRTAS------EDSCKRKKLEEELEGMRRSLKEQAIKIT-NLTQQLEQasIVKKRSE--DD 1632
Cdd:PRK11281  341 ILYQQQQALpsADLIEGLaDRIADlrleqfEINQQRDALFQPDAYIDKLEAGHKSEVTdEVRDALLQ--LLDERREllDQ 418

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1147813   1633 LRQQrdvLDGHLREK---QRTQEELRRLSsevEALRRQlLQEQ 1672
Cdd:PRK11281  419 LNKQ---LNNQLNLAinlQLNQQQLLSVS---DSLQST-LTQQ 454
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
992-1686 4.35e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.16  E-value: 4.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   992 ILQEAADVHARYIELLTRsgdyYRFLSEMLKSLEDLKLKnTKIEVLEEELRLardansencnknkfLDQNLQKYQAECSQ 1071
Cdd:COG4913  253 LLEPIRELAERYAAARER----LAELEYLRAALRLWFAQ-RRLELLEAELEE--------------LRAELARLEAELER 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1072 FKAKLASLEELKRQAELdgksAKQNLDkcYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQK----NDYDQLQKARQ 1147
Cdd:COG4913  314 LEARLDALREELDELEA----QIRGNG--GDRLEQLEREIERLERELEERERRRARLEALLAALGlplpASAEEFAALRA 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1148 CEKENLgwQKLESE-KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIK---- 1222
Cdd:COG4913  388 EAAALL--EALEEElEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEALGLDEAELPfvge 465

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1223 EISMQKEDDS------KNLRNQ----------LDRLSR--ENRDLKDEIVRLNDSILQATEQRRRAEENALQQKacgsei 1284
Cdd:COG4913  466 LIEVRPEEERwrgaieRVLGGFaltllvppehYAAALRwvNRLHLRGRLVYERVRTGLPDPERPRLDPDSLAGK------ 539

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1285 mqkkqhLEIE-------LKQVMQQRS--------EDNARHKQSL----------------------------EEAAKTIQ 1321
Cdd:COG4913  540 ------LDFKphpfrawLEAELGRRFdyvcvdspEELRRHPRAItragqvkgngtrhekddrrrirsryvlgFDNRAKLA 613

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1322 DKNKEIERLKAEFQEEAKRRWEYENELSKVRnNYDEEIISLKNQFETEInitkttihqltmqkeeDTSGYRAQIDNLTRE 1401
Cdd:COG4913  614 ALEAELAELEEELAEAEERLEALEAELDALQ-ERREALQRLAEYSWDEI----------------DVASAEREIAELEAE 676

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1402 NRSL---SEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKtiqd 1478
Cdd:COG4913  677 LERLdasSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLE---- 752

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1479 knkeiERLKQLIDKEtndrkcledenaRLQRVQYDLQKANSSATETINKLkvqEQELTRLRIDYERvsqertvkdqditR 1558
Cdd:COG4913  753 -----ERFAAALGDA------------VERELRENLEERIDALRARLNRA---EEELERAMRAFNR-------------E 799

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1559 FQNSLKELQLQKQKVEEELNRLKRTASEDsckrkkLEEELEGMRRSLKEQAI-KITNLTQQLEQAsivkkrsEDDLRQQR 1637
Cdd:COG4913  800 WPAETADLDADLESLPEYLALLDRLEEDG------LPEYEERFKELLNENSIeFVADLLSKLRRA-------IREIKERI 866

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813  1638 DVLDGHLREKQ-RTQEELR-----RLSSEVEALRRQL--LQEQESVKQAHLRNEHFQ 1686
Cdd:COG4913  867 DPLNDSLKRIPfGPGRYLRlearpRPDPEVREFRQELraVTSGASLFDEELSEARFA 923
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1235-1606 4.54e-08

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 58.37  E-value: 4.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1235 LRNQLDRLSRENRDLkdeivrlndsiLQATEQRRRAEENALQqkacgsEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
Cdd:pfam07888   32 LQNRLEECLQERAEL-----------LQAQEAANRQREKEKE------RYKRDREQWERQRRELESRVAELKEELRQSRE 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1315 EAAKtIQDKNKEIERLKAEFQEEaKRRWEYENELSKVRNNYDEEIISLKNQ----FETEINITKTTIHQLTMQK---EED 1387
Cdd:pfam07888   95 KHEE-LEEKYKELSASSEELSEE-KDALLAQRAAHEARIRELEEDIKTLTQrvleRETELERMKERAKKAGAQRkeeEAE 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1388 TSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV--TQMRTEESVRY 1465
Cdd:pfam07888  173 RKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELrsLQERLNASERK 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1466 KQSL-DDAAKTIQDKNKEIERLKQlidketndrkcledenARLQRVQYDLQKANSSatetinkLKVQE------QELTRL 1538
Cdd:pfam07888  253 VEGLgEELSSMAAQRDRTQAELHQ----------------ARLQAAQLTLQLADAS-------LALREgrarwaQERETL 309

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813    1539 RIDYErVSQERTVK-DQDITRFQNSLKELQLQKQKVEEELNRlkrtasEDSCKRKKLEE---ELEGMRRSLK 1606
Cdd:pfam07888  310 QQSAE-ADKDRIEKlSAELQRLEERLQEERMEREKLEVELGR------EKDCNRVQLSEsrrELQELKASLR 374
mukB PRK04863
chromosome partition protein MukB;
1541-1915 4.63e-08

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 59.20  E-value: 4.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1541 DYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLkeqAIKITNLTQQ-- 1618
Cdd:PRK04863  273 DYMRHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHL---NLVQTALRQQek 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1619 LEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIE--DKSRSL 1696
Cdd:PRK04863  350 IERYQADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAIQYQQAVQalERAKQL 429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1697 NE------SKIE--IERLQSLTENLTKEHLMLEEELR-----NLRLE--YDDLRR-----GRSEADSDKNATILELRSQl 1756
Cdd:PRK04863  430 CGlpdltaDNAEdwLEEFQAKEQEATEELLSLEQKLSvaqaaHSQFEqaYQLVRKiagevSRSEAWDVARELLRRLREQ- 508

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1757 QISNNRTLELQGLINDLQReRENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESllvKIKVLEQDKARLQRLEDEL 1836
Cdd:PRK04863  509 RHLAEQLQQLRMRLSELEQ-RLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEA---RLESLSESVSEARERRMAL 584

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813   1837 NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1915
Cdd:PRK04863  585 RQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALDEEIER 663
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1418-1761 4.86e-08

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 58.91  E-value: 4.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1418 QTTENLRRVEEDIQQQKATGSE------VSQRKQQLEVELRQVTQMRTEESVRYKQSlddaaktiQDKNKEI-ERLKQLI 1490
Cdd:PRK10929   72 QVIDNFPKLSAELRQQLNNERDeprsvpPNMSTDALEQEILQVSSQLLEKSRQAQQE--------QDRAREIsDSLSQLP 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1491 DKETNDRKCLEDENARLQ----------RVQYDLQKANSSAtetiNKLKVQE-----------QELTRLRID-YERVSQE 1548
Cdd:PRK10929  144 QQQTEARRQLNEIERRLQtlgtpntplaQAQLTALQAESAA----LKALVDElelaqlsannrQELARLRSElAKKRSQQ 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1549 rtvKDQDITRFQNSLKElqlQKQKVEEElnRLKRTasedsckrKKLEEELEGMRRSLKEQAIKITNLTQQLEQASivkKR 1628
Cdd:PRK10929  220 ---LDAYLQALRNQLNS---QRQREAER--ALEST--------ELLAEQSGDLPKSIVAQFKINRELSQALNQQA---QR 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1629 SEDDLRQQRDVLDGHLREKQ-----RTQEELRRLSSEV-EALRRQL--LQEQESVKQ-----AHLRNE--HFQKAIEdKS 1693
Cdd:PRK10929  281 MDLIASQQRQAASQTLQVRQalntlREQSQWLGVSNALgEALRAQVarLPEMPKPQQldtemAQLRVQrlRYEDLLN-KQ 359

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813   1694 RSLNESKieierlQSLTENLTKEHL-MLEEELRNLRLEYDDLRRGrseADSDknatILELrSQLQISNN 1761
Cdd:PRK10929  360 PQLRQIR------QADGQPLTAEQNrILDAQLRTQRELLNSLLSG---GDTL----ILEL-TKLKVANS 414
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1517-1746 4.95e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 4.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1517 ANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEE 1596
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1597 ELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVK 1676
Cdd:COG4942   98 ELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1147813  1677 QAHLRNEH----FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKN 1746
Cdd:COG4942  178 ALLAELEEeraaLEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAAL 251
PRK11281 PRK11281
mechanosensitive channel MscK;
1392-1800 5.06e-08

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 59.15  E-value: 5.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1392 RAQIDNLTrENRSLSEEIKRLKNTLTQTTENLrrveEDIQQQKATGSEVSQRKQQLEVELRQVtqmrTEESVRYKQSLDD 1471
Cdd:PRK11281   42 QAQLDALN-KQKLLEAEDKLVQQDLEQTLALL----DKIDRQKEETEQLKQQLAQAPAKLRQA----QAELEALKDDNDE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1472 AAKTIQDK--NKEIE-RLKQLIDKETNDRKCLEDENARL-------QRVQYDLQkANSSATETINKLKVQ---------- 1531
Cdd:PRK11281  113 ETRETLSTlsLRQLEsRLAQTLDQLQNAQNDLAEYNSQLvslqtqpERAQAALY-ANSQRLQQIRNLLKGgkvggkalrp 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1532 --------EQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQkvEEELNRLKRTASEdscKRKKLEEElegmrr 1603
Cdd:PRK11281  192 sqrvllqaEQALLNAQNDLQRKSLEGNTQLQDLLQKQRDYLTARIQRL--EHQLQLLQEAINS---KRLTLSEK------ 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1604 sLKEQAIKITNlTQQLEQASIVKKRSE------DDLRQQRDVLDGHLREKQRTQEELRRLS-SEvealrrQLLQEQESVK 1676
Cdd:PRK11281  261 -TVQEAQSQDE-AARIQANPLVAQELEinlqlsQRLLKATEKLNTLTQQNLRVKNWLDRLTqSE------RNIKEQISVL 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1677 QAHLRnehfqkaiedKSRSLNESKIEIERLQsLTENLTKehlmleeELRNLRLEYDDLRRGRS------------EADSD 1744
Cdd:PRK11281  333 KGSLL----------LSRILYQQQQALPSAD-LIEGLAD-------RIADLRLEQFEINQQRDalfqpdayidklEAGHK 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813   1745 KNATILELRSQLQISNNRtlelQGLINDLQRERENLRQE---IEKFQKQALEASNRIQE 1800
Cdd:PRK11281  395 SEVTDEVRDALLQLLDER----RELLDQLNKQLNNQLNLainLQLNQQQLLSVSDSLQS 449
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1629-1847 5.17e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 5.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1629 SEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQs 1708
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1709 ltENLTKEHLMLEEELRNL----RLEYDD-LRRGRSEADSDKNATIL-----ELRSQLQISNNRTLELQGLINDLQRERE 1778
Cdd:COG4942   97 --AELEAQKEELAELLRALyrlgRQPPLAlLLSPEDFLDAVRRLQYLkylapARREQAEELRADLAELAALRAELEAERA 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813  1779 NLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1847
Cdd:COG4942  175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERT 243
PLEC smart00250
Plectin repeat;
2724-2757 5.37e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 50.94  E-value: 5.37e-08
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1147813     2724 QRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFID 2757
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLID 34
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1414-1668 8.30e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.08  E-value: 8.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1414 NTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQmrteesvrykqSLDDAAKTIQDKNKEI----ERLKQL 1489
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER-----------RIAALARRIRALEQELaaleAELAEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1490 IDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERtvkDQDITRFQNSLKELQLQ 1569
Cdd:COG4942   89 EKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR---REQAEELRADLAELAAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1570 KQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQasivKKRSEDDLRQQRDVLdghlrEKQR 1649
Cdd:COG4942  166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAE----LQQEAEELEALIARL-----EAEA 236

                        250
                 ....*....|....*....
gi 1147813  1650 TQEELRRLSSEVEALRRQL 1668
Cdd:COG4942  237 AAAAERTPAAGFAALKGKL 255
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1608-1831 9.06e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.08  E-value: 9.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1608 QAIKITNLTQQLEQASIVKKRSEDDLRQQRdvldghlREKQRTQEELRRLSSEVEALRRQL--LQEQESVKQAHLRNehF 1685
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALK-------KEEKALLKQLAALERRIAALARRIraLEQELAALEAELAE--L 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1686 QKAIEDKSRSLNESKIEI-ERLQSLTENLTKEHLML-------EEELRNLRLeYDDLRRGRSEADSDKNATILELRSQLQ 1757
Cdd:COG4942   89 EKEIAELRAELEAQKEELaELLRALYRLGRQPPLALllspedfLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRA 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1147813  1758 ISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR 1831
Cdd:COG4942  168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 916-1644 1.38e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 57.75  E-value: 1.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     916 KFGDSNTVMRFLNEQKN-LHSEISGKRDKSEEVQkiaelCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQ 994
Cdd:TIGR00606  327 ELEKLNKERRLLNQEKTeLLVEQGRLQLQADRHQ-----EHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLVIE 401

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     995 EAADVHARYIELLTRSGDYYRFLSEMLKSLED--------LKLKNTKIEVLEEELRLARD--ANSENCNKNKF-LDQNLQ 1063
Cdd:TIGR00606  402 RQEDEAKTAAQLCADLQSKERLKQEQADEIRDekkglgrtIELKKEILEKKQEELKFVIKelQQLEGSSDRILeLDQELR 481

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1064 KYQAECSqfKAKLASLEELKRQAELDGKSAKQNLDKcygQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
Cdd:TIGR00606  482 KAERELS--KAEKNSLTETLKKEVKSLQNEKADLDR---KLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKS 556

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1144 KARQCEKENLGW--QKLESEKAIKEKEYEIERLRvllqeegTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI 1221
Cdd:TIGR00606  557 RHSDELTSLLGYfpNKKQLEDWLHSKSKEINQTR-------DRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLF 629

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1222 KEISMQKED-DSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATE---------QRRRAEENALQ--------------- 1276
Cdd:TIGR00606  630 DVCGSQDEEsDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDenqsccpvcQRVFQTEAELQefisdlqsklrlapd 709

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1277 -QKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQsLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNY 1355
Cdd:TIGR00606  710 kLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKE-IPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCL 788

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1356 DEEIISLKNQFETEINITKT--------------TIHQLTMQKEEDTSGYRaQIDNLTRENRSLSEE----IKRLKNTLT 1417
Cdd:TIGR00606  789 TDVTIMERFQMELKDVERKIaqqaaklqgsdldrTVQQVNQEKQEKQHELD-TVVSKIELNRKLIQDqqeqIQHLKSKTN 867

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1418 -------QTTENLRR-------VEEDIQQQKATGSEVSQRKQQ---LEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKN 1480
Cdd:TIGR00606  868 elkseklQIGTNLQRrqqfeeqLVELSTEVQSLIREIKDAKEQdspLETFLEKDQQEKEELISSKETSNKKAQDKVNDIK 947

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1481 KEIERL----------------KQLIDKETNDRKC---LEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRID 1541
Cdd:TIGR00606  948 EKVKNIhgymkdienkiqdgkdDYLKQKETELNTVnaqLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRE 1027

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1542 YERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKitNLTQQLEQ 1621
Cdd:TIGR00606 1028 NELKEVEEELKQHLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFR--DAEEKYRE 1105

                          810       820
                   ....*....|....*....|....*.
gi 1147813    1622 ASIV---KKRSEDDLRQQRDVLDGHL 1644
Cdd:TIGR00606 1106 MMIVmrtTELVNKDLDIYYKTLDQAI 1131
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1393-1943 1.65e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.16  E-value: 1.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1393 AQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDA 1472
Cdd:pfam12128  234 AGIMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAA 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1473 AKTIQDKNKEIERLkqlidketnDRKCLEDENARLQRVQYDLQKANSSATEtinkLKVQEQELTRLridyervsqerTVK 1552
Cdd:pfam12128  314 DAAVAKDRSELEAL---------EDQHGAFLDADIETAAADQEQLPSWQSE----LENLEERLKAL-----------TGK 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1553 DQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEE--LEGMRRSLKEQaikitnLTQQLEQASIVKKRSE 1630
Cdd:pfam12128  370 HQDVTAKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEddLQALESELREQ------LEAGKLEFNEEEYRLK 443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1631 DDLRQQRDVLDGHLREKQrTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLT 1710
Cdd:pfam12128  444 SRLGELKLRLNQATATPE-LLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSAL 522

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1711 ENLtkeHLMLEEELRNLrLEYddLRR---GRSEADSDKNATILELRSQL-----QISNNRTLELQGLINDLQR------- 1775
Cdd:pfam12128  523 DEL---ELQLFPQAGTL-LHF--LRKeapDWEQSIGKVISPELLHRTDLdpevwDGSVGGELNLYGVKLDLKRidvpewa 596

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1776 -ERENLRQEIEKFQKQALEASNRIQESKNQctqvvqeresllvkikvLEQDKARLQRLEDELNRAKSTLEAETRVKQRLE 1854
Cdd:pfam12128  597 aSEEELRERLDKAEEALQSAREKQAAAEEQ-----------------LVQANGELEKASREETFARTALKNARLDLRRLF 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1855 CEKQQIQNDLNQwktqysRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934
Cdd:pfam12128  660 DEKQSEKDKKNK------ALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLAL 733


                   ....*....
gi 1147813    1935 YQREIDKLR 1943
Cdd:pfam12128  734 LKAAIAARR 742
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1465-1945 1.76e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 57.04  E-value: 1.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1465 YKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETI--NKLKVQEQELTR----- 1537
Cdd:pfam05483   80 YSKLYKEAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIqeNKDLIKENNATRhlcnl 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1538 ------------LRIDYERVSQERTVKD--QDITRFQNSLKELQLQKQKVEEELN-RLKrtasEDSCKRKKLEEELEGMR 1602
Cdd:pfam05483  160 lketcarsaektKKYEYEREETRQVYMDlnNNIEKMILAFEELRVQAENARLEMHfKLK----EDHEKIQHLEEEYKKEI 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1603 RSLKEQA----IKITNLTQQLEQASIVKKRSEDDLRQqrdvldghLREKQRTQEELRRLSSEVealRRQLLQEQESVKQA 1678
Cdd:pfam05483  236 NDKEKQVslllIQITEKENKMKDLTFLLEESRDKANQ--------LEEKTKLQDENLKELIEK---KDHLTKELEDIKMS 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1679 HLRNEHFQKAIEDKSRSLNESKIEI-ERLQSLTENLTK---EHLMLEEELRNLRLEYDDLRRG---RSEADSDKNATIL- 1750
Cdd:pfam05483  305 LQRSMSTQKALEEDLQIATKTICQLtEEKEAQMEELNKakaAHSFVVTEFEATTCSLEELLRTeqqRLEKNEDQLKIITm 384

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1751 -------ELRSQLQISNNRTLELQGLINDLQrERENLRQEIEKFQKQALEASNRIQE--------------SKNQCTQVV 1809
Cdd:pfam05483  385 elqkkssELEEMTKFKNNKEVELEELKKILA-EDEKLLDEKKQFEKIAEELKGKEQElifllqarekeihdLEIQLTAIK 463

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1810 QERESLLVKIKVL--EQDKARLQRLEDELNRAKSTLEAETRVKQR----LECEKQqiQNDLNQWKTQYSRKEEAIRKIES 1883
Cdd:pfam05483  464 TSEEHYLKEVEDLktELEKEKLKNIELTAHCDKLLLENKELTQEAsdmtLELKKH--QEDIINCKKQEERMLKQIENLEE 541

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813    1884 EREksereknSLRSEIERLQAEIKRIEERCRRKLeDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:pfam05483  542 KEM-------NLRDELESVREEFIQKGDEVKCKL-DKSEENARSIEYEVLKKEKQMKILENK 595
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1170-1583 1.99e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.70  E-value: 1.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1170 EIERLRVLLQEEGTRKREYeNELAKVRNHYNEEMSNLRNKYETeinitkttikeisMQKEDDSKNLRNQLDRLSRENRDL 1249
Cdd:COG4717   72 ELKELEEELKEAEEKEEEY-AELQEELEELEEELEELEAELEE-------------LREELEKLEKLLQLLPLYQELEAL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1250 KDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
Cdd:COG4717  138 EAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEE 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1330 LKAEFQ--EEAKRRWEYENELSKVRNNYDEEIISL-------------KNQFETEINI---------------TKTTIHQ 1379
Cdd:COG4717  218 AQEELEelEEELEQLENELEAAALEERLKEARLLLliaaallallglgGSLLSLILTIagvlflvlgllallfLLLAREK 297

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1380 LTMQKEEDTSGYRAQIDNLtrENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVE--------L 1451
Cdd:COG4717  298 ASLGKEAEELQALPALEEL--EEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEeleqeiaaL 375

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1452 RQVTQMRTEESVRYKQsldDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDE------NARLQRVQYDLQKANSSATETI 1525
Cdd:COG4717  376 LAEAGVEDEEELRAAL---EQAEEYQELKEELEELEEQLEELLGELEELLEAldeeelEEELEELEEELEELEEELEELR 452

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1526 NKLKVQEQELTRLRID--YERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT 1583
Cdd:COG4717  453 EELAELEAELEQLEEDgeLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1091-1920 2.22e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 56.98  E-value: 2.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1091 KSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDrfdQQKNDYDQLQKarqCEKENLGWQKLESE-----KAIK 1165
Cdd:TIGR01612  540 KEIEAGLKESYELAKNWKKLIHEIKKELEEENEDSIHLEK---EIKDLFDKYLE---IDDEIIYINKLKLElkekiKNIS 613

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1166 EKEYEIERlRVLLQEEGTRKREYENELAKVRNHYNEEmsNLRNKYEteinITKTTIKEISMQKEDDSKNLRNQLDRLSRE 1245
Cdd:TIGR01612  614 DKNEYIKK-AIDLKKIIENNNAYIDELAKISPYQVPE--HLKNKDK----IYSTIKSELSKIYEDDIDALYNELSSIVKE 686

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1246 N-----------RDLKDEIVRLNDSILQATEQRRRAEENALQQKA--CGSEIMQKKQHLEIELKQVMQQRSEDNARHKQS 1312
Cdd:TIGR01612  687 NaidntedkaklDDLKSKIDKEYDKIQNMETATVELHLSNIENKKneLLDIIVEIKKHIHGEINKDLNKILEDFKNKEKE 766

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1313 LEEAAKTIQDKNKEIERLKAEF-----------------QEEAKRRWEY-----------ENELSKVRN---NYDEEIIS 1361
Cdd:TIGR01612  767 LSNKINDYAKEKDELNKYKSKIseiknhyndqinidnikDEDAKQNYDKskeyiktisikEDEIFKIINemkFMKDDFLN 846

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1362 -------LKNQFETEINITKTTIHQLTMQKEEDTSGYRAQI-DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQ 1433
Cdd:TIGR01612  847 kvdkfinFENNCKEKIDSEHEQFAELTNKIKAEISDDKLNDyEKKFNDSKSLINEINKSIEEEYQNINTLKKVDEYIKIC 926

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1434 KATGSEVSQ---RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIErlKQLIDKETNDrkcLEDENARLQRV 1510
Cdd:TIGR01612  927 ENTKESIEKfhnKQNILKEILNKNIDTIKESNLIEKSYKDKFDNTLIDKINELD--KAFKDASLND---YEAKNNELIKY 1001

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1511 QYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDI---TRFQNSLKELQLQKQKVEEELNR-LKRTASE 1586
Cdd:TIGR01612 1002 FNDLKANLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIaihTSIYNIIDEIEKEIGKNIELLNKeILEEAEI 1081

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1587 DSCKRKKLEEELEGMRRS--LKEQAIKITNLTQQLeqasivkkrsEDDLRQQRDVLDGHLRE----KQRTQEELRRLSSE 1660
Cdd:TIGR01612 1082 NITNFNEIKEKLKHYNFDdfGKEENIKYADEINKI----------KDDIKNLDQKIDHHIKAleeiKKKSENYIDEIKAQ 1151

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1661 VEALRR--QLLQEQESVKQAHLRNEHF------QKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732
Cdd:TIGR01612 1152 INDLEDvaDKAISNDDPEEIEKKIENIvtkidkKKNIYDEIKKLLNEIAEIEKDKTSLEEVKGINLSYGKNLGKLFLEKI 1231

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1733 DLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNR---IQESKNQCTQVV 1809
Cdd:TIGR01612 1232 DEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHdenISDIREKSLKII 1311

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1810 QE--RESLLVKI-KVLEQDKARLQRLEDELNRAKSTLeaeTRVKQRLECEKqqIQNDLNQWKtQYSRKEEAIRKiesere 1886
Cdd:TIGR01612 1312 EDfsEESDINDIkKELQKNLLDAQKHNSDINLYLNEI---ANIYNILKLNK--IKKIIDEVK-EYTKEIEENNK------ 1379

                          890       900       910
                   ....*....|....*....|....*....|....*....
gi 1147813    1887 ksereknSLRSEIERLQAEIKRIEE-----RCRRKLEDS 1920
Cdd:TIGR01612 1380 -------NIKDELDKSEKLIKKIKDdinleECKSKIEST 1411
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1062-1211 2.61e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.16  E-value: 2.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN--DY 1139
Cdd:COG1579   12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNnkEY 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813  1140 DQLQKarqcEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYE 1211
Cdd:COG1579   92 EALQK----EIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1702-1928 3.05e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.46  E-value: 3.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1702 EIERLQSLTENLTKEHLMLE---------EELRNLRLEYDDLRRGRSEADSDKNATILELRSQlqisnnRTLELQGLIND 1772
Cdd:COG4913  226 AADALVEHFDDLERAHEALEdareqiellEPIRELAERYAAARERLAELEYLRAALRLWFAQR------RLELLEAELEE 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1773 LQRERENLRQEIEKFQKQALEASNRIQESKNQCTQV-VQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET-RVK 1850
Cdd:COG4913  300 LRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLpASA 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1851 QRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER---CRRKLEDSTRETQSQ 1927
Cdd:COG4913  380 EEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARllaLRDALAEALGLDEAE 459


                 .
gi 1147813  1928 L 1928
Cdd:COG4913  460 L 460
PLEC smart00250
Plectin repeat;
2084-2121 3.42e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.63  E-value: 3.42e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETG 2121
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2468-2496 3.52e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 48.48  E-value: 3.52e-07
                           10        20
                   ....*....|....*....|....*....
gi 1147813    2468 IVDPETNKEMSVQEAYKKGLIDYETFKEL 2496
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
2048-2083 4.16e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.25  E-value: 4.16e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1147813     2048 LLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1201-1820 4.64e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 56.21  E-value: 4.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1201 EEMSNLRNKYETEINITKTTikEISMQKEDDSKNLRNQLDRLS---RENRDLKDEIVRLN---DSILQATEQRRRaEENA 1274
Cdd:TIGR01612 1950 EIYTKIRDSYDTLLDIFKKS--QDLHKKEQDTLNIIFENQQLYekiQASNELKDTLSDLKykkEKILNDVKLLLH-KFDE 2026

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1275 LQQKACGSE----IMQKKQHLEIELKQVMQQRSEDN-------ARHKQSLEEAAKTIQ---DKNKEIERLKAEFQEEAKR 1340
Cdd:TIGR01612 2027 LNKLSCDSQnydtILELSKQDKIKEKIDNYEKEKEKfgidfdvKAMEEKFDNDIKDIEkfeNNYKHSEKDNHDFSEEKDN 2106

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1341 RWEYENELSKVRNNYDEEIISLKNQFeteinITKT-TIHQLT-MQKEEDTSGYRAQIDNLTRENRSLSEEIkrlkNTLTQ 1418
Cdd:TIGR01612 2107 IIQSKKKLKELTEAFNTEIKIIEDKI-----IEKNdLIDKLIeMRKECLLFSYATLVETLKSKVINHSEFI----TSAAK 2177

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1419 TTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMrteesvrykqsLDDAAKtiqDKNKEIERLKQ---------- 1488
Cdd:TIGR01612 2178 FSKDFFEFIEDISDSLNDDIDALQIKYNLNQTKKHMISI-----------LADATK---DHNNLIEKEKEatkiinnlte 2243

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1489 --LIDKETNDRKCLEDENARLQRVQYDLQKAnssaTETINKL--KVQEQELTRLRIDYERVSqertvkdqDITR-FQNSL 1563
Cdd:TIGR01612 2244 lfTIDFNNADADILHNNKIQIIYFNSELHKS----IESIKKLykKINAFKLLNISHINEKYF--------DISKeFDNII 2311

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1564 kelQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMR----RSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV 1639
Cdd:TIGR01612 2312 ---QLQKHKLTENLNDLKEIDQYISDKKNIFLHALNENTnfnfNALKEIYDDIINRENKADEIENINNKENENIMQYIDT 2388

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1640 LDgHLREKQRTQEELRRLSSEVEALRRQLLQE---------QESVKQAHLRNEHFQKAIED------KSRSLNESKIEIE 1704
Cdd:TIGR01612 2389 IT-KLTEKIQDILIFVTTYENDNNIIKQHIQDndendvskiKDNLKKTIQSFQEILNKIDEikaqfyGGNNINNIIITIS 2467

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1705 RLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDK-----NATILELRSQL-QISNNRTLELQGLINDLqrerE 1778
Cdd:TIGR01612 2468 QNANDVKNHFSKDLTIENELIQIQKRLEDIKNAAHEIRSEQitkytNAIHNHIEEQFkKIENNSNKDEVYKINEI----D 2543

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|..
gi 1147813    1779 NLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIK 1820
Cdd:TIGR01612 2544 NIIEKIINYNKEPEVKLHAIIDNKNEFASIIPDIKNLIALIE 2585
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1393-1956 4.82e-07

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 55.60  E-value: 4.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1393 AQIDNLTRENRSLSEEIkrlkntltqttenlrrveeDIQQQKaTGSEVSQRKQQLEVELRQVTQMRTEESVRyKQSLDDA 1472
Cdd:pfam10174    3 AQLRDLQRENELLRREL-------------------DIKESK-LGSSMNSIKTFWSPELKKERALRKEEAAR-ISVLKEQ 61

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1473 AKTIQDKNKEIERLKQLIDKETNDRKCLEdenarlQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVk 1552
Cdd:pfam10174   62 YRVTQEENQHLQLTIQALQDELRAQRDLN------QLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQAKELFL- 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1553 dqditrFQNSLKELQL----QKQKVEEELNRLKRTASEDSCK--RKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI-- 1624
Cdd:pfam10174  135 ------LRKTLEEMELrietQKQTLGARDESIKKLLEMLQSKglPKKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKen 208

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1625 VKKRSEDDLRQQ-----------RDVLDGHLREKQRTQEELRRLSSEVEALRRQLL----QEQESVKQAHLRNEH--FQK 1687
Cdd:pfam10174  209 IHLREELHRRNQlqpdpaktkalQTVIEMKDTKISSLERNIRDLEDEVQMLKTNGLlhteDREEEIKQMEVYKSHskFMK 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1688 A-IEDKSRSLNESKIEIERLQSLTENLT-------------KEHLMLEEELRN-LRLEYDDLRRGRSEADS---DKNATI 1749
Cdd:pfam10174  289 NkIDQLKQELSKKESELLALQTKLETLTnqnsdckqhievlKESLTAKEQRAAiLQTEVDALRLRLEEKESflnKKTKQL 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1750 LELRSQLQISNNRTLELQGL-------INDLQRERENLRQEIEKFQKQALEASNRIQE----SKNQCTQVVQERESLLVK 1818
Cdd:pfam10174  369 QDLTEEKSTLAGEIRDLKDMldvkerkINVLQKKIENLQEQLRDKDKQLAGLKERVKSlqtdSSNTDTALTTLEEALSEK 448

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1819 IKVLE--------QDKARLQRLEDeLNRAKSTLEAETRVKQRLECEKQQIQNDLnqwKTQYSRKEEAIRKIESEREKSER 1890
Cdd:pfam10174  449 ERIIErlkeqrerEDRERLEELES-LKKENKDLKEKVSALQPELTEKESSLIDL---KEHASSLASSGLKKDSKLKSLEI 524

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813    1891 EKNSLRSEIERLQAEIKR---IEERCRRKLEDSTRetQSQLETERSRYQREIDKLR---QRPYGSHRETQTE 1956
Cdd:pfam10174  525 AVEQKKEECSKLENQLKKahnAEEAVRTNPEINDR--IRLLEQEVARYKEESGKAQaevERLLGILREVENE 594
PRK12704 PRK12704
phosphodiesterase; Provisional
 1314-1498 4.85e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 55.17  E-value: 4.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1314 EEAAKTIQDKNKEIERLKAEFQEEAKrrweyenelskvrnnydEEIISLKNQFETEINITKTTIHQL---TMQKEEdtsg 1390
Cdd:PRK12704   38 EEAKRILEEAKKEAEAIKKEALLEAK-----------------EEIHKLRNEFEKELRERRNELQKLekrLLQKEE---- 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1391 yraqidNLTREnrslSEEIKRLKNTLTQTTENLRRVEEDIQQQKAtgsEVSQRKQQLEVELRQVTQMRTEE-------SV 1463
Cdd:PRK12704   97 ------NLDRK----LELLEKREEELEKKEKELEQKQQELEKKEE---ELEELIEEQLQELERISGLTAEEakeilleKV 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1147813   1464 RyKQSLDDAAKTIQDKNKEIerlkqlidKETNDRK 1498
Cdd:PRK12704  164 E-EEARHEAAVLIKEIEEEA--------KEEADKK 189
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1510-1753 4.95e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.41  E-value: 4.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1510 VQYDLQKANSSATETINKLkvqEQELTRLRidyERVSQertvKDQDITRF--QNSLKELQLQKQKVEEELNRLKRTASED 1587
Cdd:COG3206  162 LEQNLELRREEARKALEFL---EEQLPELR---KELEE----AEAALEEFrqKNGLVDLSEEAKLLLQQLSELESQLAEA 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1588 SCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEddLRQQRDVLDGHLREKQrtqEELRRLSSEVEALRRQ 1667
Cdd:COG3206  232 RAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAE--LEAELAELSARYTPNH---PDVIALRAQIAALRAQ 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1668 LLQEQESVKQAhLRNEhfQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNA 1747
Cdd:COG3206  307 LQQEAQRILAS-LEAE--LEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEAL 383


                 ....*.
gi 1147813  1748 TILELR 1753
Cdd:COG3206  384 TVGNVR 389
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 1689-1904 5.35e-07

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 54.69  E-value: 5.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1689 IEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDL---------RRGRSEAD-SDKNATILELRSQLQI 1758
Cdd:pfam19220   36 IEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAegeleelvaRLAKLEAAlREAEAAKEELRIELRD 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1759 SNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVvQERESLLvkikvlEQDKARLQRLEDELNR 1838
Cdd:pfam19220  116 KTAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATA-RERLALL------EQENRRLQALSEEQAA 188

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813    1839 AKSTLEAE-TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQA 1904
Cdd:pfam19220  189 ELAELTRRlAELETQLDATRARLRALEGQLAAEQAERERAEAQLEEAVEAHRAERASLRMKLEALTA 255
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1028-1488 6.18e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.16  E-value: 6.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1028 KLKNTKIEVLEEELRLARDANSENcnknKFLDQNLQKYQAECSQFKAKLASLEElkrqaELDGKSAKQNLDKCYGQIKEL 1107
Cdd:COG4717   67 ELNLKELKELEEELKEAEEKEEEY----AELQEELEELEEELEELEAELEELRE-----ELEKLEKLLQLLPLYQELEAL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRvllqeegTRKRE 1187
Cdd:COG4717  138 EAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQ-------QRLAE 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1188 YENELAKVRnhynEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLND--------- 1258
Cdd:COG4717  211 LEEELEEAQ----EELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGvlflvlgll 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1259 ----SILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHkqsLEEAAKTIQDKNKEIERLKAEF 1334
Cdd:COG4717  287 allfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLE---LLDRIEELQELLREAEELEEEL 363

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1335 QEEAKRRwEYENELSKVRNNYDEEIISLKNQFETEINItKTTIHQLTMQKEEDTSGYRAQIDNLTREN-----RSLSEEI 1409
Cdd:COG4717  364 QLEELEQ-EIAALLAEAGVEDEEELRAALEQAEEYQEL-KEELEELEEQLEELLGELEELLEALDEEEleeelEELEEEL 441

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813  1410 KRLKNTLTQTTENLRRVEEDIQQQkATGSEVSQRKQQLEVELRQVTQMrteesVRYKQSLDDAAKTIQDKNKEIERLKQ 1488
Cdd:COG4717  442 EELEEELEELREELAELEAELEQL-EEDGELAELLQELEELKAELREL-----AEEWAALKLALELLEEAREEYREERL 514
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1295-1571 7.90e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.02  E-value: 7.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1295 LKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKrrweyenelskvrnnydeeIISLknqfeteinitk 1374
Cdd:COG3206  162 LEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNG-------------------LVDL------------ 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1375 ttihqltmqkEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKAtgsevSQRKQQLEVELRQV 1454
Cdd:COG3206  211 ----------SEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAEL 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1455 TQMRTEESVRYKqsldDAAKTIQDKNKEIERLKQLIDKETND-RKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ 1533
Cdd:COG3206  276 EAELAELSARYT----PNHPDVIALRAQIAALRAQLQQEAQRiLASLEAELEALQAREASLQAQLAQLEARLAELPELEA 351

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 1147813  1534 ELTRLRidyervsQERTVKDQDITRFQNSLKELQLQKQ 1571
Cdd:COG3206  352 ELRRLE-------REVEVARELYESLLQRLEEARLAEA 382
PLEC smart00250
Plectin repeat;
2291-2325 9.56e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 47.48  E-value: 9.56e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1147813     2291 LLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEF 2325
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1094-1671 1.12e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 54.52  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1094 KQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-----RQCEKENlgwqKLESE-KAIKEK 1167
Cdd:PRK01156  189 EEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSAlnelsSLEDMKN----RYESEiKTAESD 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1168 EYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEIS-----MQKEDDSKNLRNQLDRL 1242
Cdd:PRK01156  265 LSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINkyhaiIKKLSVLQKDYNDYIKK 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1243 SRENRDLKDEIVRLND------SILQATEQ-RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNArhkqSLEE 1315
Cdd:PRK01156  345 KSRYDDLNNQILELEGyemdynSYLKSIESlKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINV----KLQD 420

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1316 AAKTIQDKNKEIERLKaEFQEEAKRRWEY---------------ENELSKVRNNYDEEIISLK---NQFETEINITKTTI 1377
Cdd:PRK01156  421 ISSKVSSLNQRIRALR-ENLDELSRNMEMlngqsvcpvcgttlgEEKSNHIINHYNEKKSRLEekiREIEIEVKDIDEKI 499

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1378 HQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQM 1457
Cdd:PRK01156  500 VDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVISL 579

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1458 RTEESVR-----YKQSLDDAAKTIQDKNKEIERLKQLIDKETndrKCLEDEnARLQRVQYDLQKANSSATETINKlkvqe 1532
Cdd:PRK01156  580 IDIETNRsrsneIKKQLNDLESRLQEIEIGFPDDKSYIDKSI---REIENE-ANNLNNKYNEIQENKILIEKLRG----- 650

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1533 qeltrlRIDYERvsqERTVKDQDItrfQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI 1612
Cdd:PRK01156  651 ------KIDNYK---KQIAEIDSI---IPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRI 718

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1613 TNLTQQLEQASIVKKrSEDDLRQQRDVLDghlreKQRTQEELRRLSSE-VEALRRQLLQE 1671
Cdd:PRK01156  719 NDINETLESMKKIKK-AIGDLKRLREAFD-----KSGVPAMIRKSASQaMTSLTRKYLFE 772
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 659-1468 1.14e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 54.74  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     659 RENDKQETWMlmelQKIRRQIEHCEGRMTLKNLPLADQGSshhitvKINELKSVQNDSQAiaeVLNQLKDMLANF-RGSE 737
Cdd:pfam15921  135 RESQSQEDLR----NQLQNTVHELEAAKCLKEDMLEDSNT------QIEQLRKMMLSHEG---VLQEIRSILVDFeEASG 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     738 KYCYLQNEVFGLfqKLENINGVTDGYLNSLCTVRALLQA-ILQTEDMLKVYEARLTEEETVCLDL--DKVEAYRCGLKKI 814
Cdd:pfam15921  202 KKIYEHDSMSTM--HFRSLGSAISKILRELDTEISYLKGrIFPVEDQLEALKSESQNKIELLLQQhqDRIEQLISEHEVE 279

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     815 KNDLNLKKSLLATMKTELQKAQQI-HSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ-------IK 886
Cdd:pfam15921  280 ITGLTEKASSARSQANSIQSQLEIiQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQlvlanseLT 359

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     887 QLRNYRDNYQ--------AFCKWLYDRKRRQDSLESMK----------FGDSNTVmrflneqKNLHSEISgkrDKSEEVQ 948
Cdd:pfam15921  360 EARTERDQFSqesgnlddQLQKLLADLHKREKELSLEKeqnkrlwdrdTGNSITI-------DHLRRELD---DRNMEVQ 429

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     949 KIAELC----ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSgdyyRFLSEMLKSL 1024
Cdd:pfam15921  430 RLEALLkamkSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSE----RTVSDLTASL 505

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1025 EDlklKNTKIEVLEEE---LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLAS----LEELKRQAEldgksakqNL 1097
Cdd:pfam15921  506 QE---KERAIEATNAEitkLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMAEkdkvIEILRQQIE--------NM 574

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1098 DKCYGQ----IKELNEKITRLTYEIED---EKRRRKSVEDRFDQQKNDYDQLQKARQCEK---ENLGWQKLESEKAIK-E 1166
Cdd:pfam15921  575 TQLVGQhgrtAGAMQVEKAQLEKEINDrrlELQEFKILKDKKDAKIRELEARVSDLELEKvklVNAGSERLRAVKDIKqE 654

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1167 KEYEIERLRVLLQEEGTRKREYENELAKVRNHyNEEMSNLRNKY-------ETEINITKTTIKE------------ISMQ 1227
Cdd:pfam15921  655 RDQLLNEVKTSRNELNSLSEDYEVLKRNFRNK-SEEMETTTNKLkmqlksaQSELEQTRNTLKSmegsdghamkvaMGMQ 733

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1228 KEDDSKnlRNQLDRlsrenrdLKDEIVRLNDSILQATEQRR--RAEENALQQKACGSEIMQKKQHLEIELKQVMQQR-SE 1304
Cdd:pfam15921  734 KQITAK--RGQIDA-------LQSKIQFLEEAMTNANKEKHflKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRlKE 804

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1305 DNARHKQSLEEAAKTIQDKNKEIERlkaEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQK 1384
Cdd:pfam15921  805 KVANMEVALDKASLQFAECQDIIQR---QEQESVRLKLQHTLDVKELQGPGYTSNSSMKPRLLQPASFTRTHSNVPSSQS 881

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1385 EEDTSGYRAQIDNLTREN--RSLSEEIKRLKNTLTQT-TENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE 1461
Cdd:pfam15921  882 TASFLSHHSRKTNALKEDptRDLKQLLQELRSVINEEpTVQLSKAEDKGRAPSLGALDDRVRDCIIESSLRSDICHSSSN 961


                   ....*..
gi 1147813    1462 SVRYKQS 1468
Cdd:pfam15921  962 SLQTEGS 968
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1387-1724 1.18e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 54.70  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1387 DTSGYRAQIDNLTRENRSLSEEIKRlKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEV--ELRQVTQMRTEESVR 1464
Cdd:COG5022  804 SLLGSRKEYRSYLACIIKLQKTIKR-EKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLLKkeTIYLQSAQRVELAER 882

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1465 YKQSLDDAAKTIQD-----------------------------KNKEIERLKQLIDK-----------ETNDRKC-LEDE 1503
Cdd:COG5022  883 QLQELKIDVKSISSlklvnleleseiielkkslssdlienlefKTELIARLKKLLNNidleegpsieyVKLPELNkLHEV 962

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1504 NARLQRVQYDLQKANSSATETINKLKVQEQELtrlridyERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT 1583
Cdd:COG5022  963 ESKLKETSEEYEDLLKKSTILVREGNKANSEL-------KNFKKELAELSKQYGALQESTKQLKELPVEVAELQSASKII 1035

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1584 ASEDSCKRKKLEEElEGMRRSLKEQaikiTNLTQQLEQASIVKKRSEDDLRQqrdvldghlrekQRTQEELRRLSSEVEA 1663
Cdd:COG5022 1036 SSESTELSILKPLQ-KLKGLLLLEN----NQLQARYKALKLRRENSLLDDKQ------------LYQLESTENLLKTINV 1098

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1147813  1664 LRRQlLQEQESVKQAHLRNEHFQKAIedKSRSLNESKIEIERLQSLTENLTKEHLMLEEEL 1724
Cdd:COG5022 1099 KDLE-VTNRNLVKPANVLQFIVAQMI--KLNLLQEISKFLSQLVNTLEPVFQKLSVLQLEL 1156
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 949-1369 1.21e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 54.30  E-value: 1.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     949 KIAELCANSIKDYELQLASYTSGLETLLN-IPIKRTMIQSPSGVILQEAADVHAryiELLTRSGDYYRFLSEMLKSLEDL 1027
Cdd:TIGR02169  663 RGGILFSRSEPAELQRLRERLEGLKRELSsLQSELRRIENRLDELSQELSDASR---KIGEIEKEIEQLEQEEEKLKERL 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1028 KLKNTKIEVLEEELRLARDansencnKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDgksakqnldkcygqikel 1107
Cdd:TIGR02169  740 EELEEDLSSLEQEIENVKS-------ELKELEARIEELEEDLHKLEEALNDLEARLSHSRIP------------------ 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1108 neKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRvllqeegTRKRE 1187
Cdd:TIGR02169  795 --EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLN-------GKKEE 865

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1188 YENELAKVRNHYNEemsnlrnkyeteinitkttikeismqkeddsknLRNQLDRLSRENRDLKDEIVRLNDSILQATEQR 1267
Cdd:TIGR02169  866 LEEELEELEAALRD---------------------------------LESRLGDLKKERDELEAQLRELERKIEELEAQI 912

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1268 RRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDnarhkQSLEEAAKTIQDKNKEIERL-----KA--EFQEEAKR 1340
Cdd:TIGR02169  913 EKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEE-----LSLEDVQAELQRVEEEIRALepvnmLAiqEYEEVLKR 987

                          410       420
                   ....*....|....*....|....*....
gi 1147813    1341 RWEYENELSKVRNNyDEEIISLKNQFETE 1369
Cdd:TIGR02169  988 LDELKEKRAKLEEE-RKAILERIEEYEKK 1015
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 190-366 1.23e-06

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 52.06  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   190 ECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA---DLREKSAIY---------QLEEEYEN 257
Cdd:cd00176   11 ELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNElgeQLIEEGHPDaeeiqerleELNQRWEE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   258 LLKASFERMDHL---RQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESD 334
Cdd:cd00176   91 LRELAEERRQRLeeaLDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSLNELAE 170

                        170       180       190
                 ....*....|....*....|....*....|...
gi 1147813   335 QLVLNQHPAS-DKIEAYMDTLQTQWSWILQITK 366
Cdd:cd00176  171 ELLEEGHPDAdEEIEEKLEELNERWEELLELAE 203
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1594-1877 1.23e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 54.25  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1594 LEEELEGMR-RSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVldghlREKQRTQ-----------EELRRLsseV 1661
Cdd:COG3206   83 LETQIEILKsRPVLERVVDKLNLDEDPLGEEASREAAIERLRKNLTV-----EPVKGSNvieisytspdpELAAAV---A 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1662 EALRRQLLQEQESVKQAHLRN--EHFQKAIEDKSRSLNESKIEIE--RLQSLTENLTKEHLMLEEELRNLRLEYDDLRRG 1737
Cdd:COG3206  155 NALAEAYLEQNLELRREEARKalEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAE 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1738 RSEAdsdkNATILELRSQLQISNNRTLELQG--LINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESL 1815
Cdd:COG3206  235 LAEA----EARLAALRAQLGSGPDALPELLQspVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQE 310

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813  1816 LVKIKV-LEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQY----SRKEEA 1877
Cdd:COG3206  311 AQRILAsLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYesllQRLEEA 377
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1596-1839 1.24e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.54  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1596 EELEGMRRSLkeqaikitnltqqleqasivkkrseDDLRQQRDVLdGHLREKQRTQEELRRLSSEVEALRRQLlqeqeSV 1675
Cdd:COG4913  235 DDLERAHEAL-------------------------EDAREQIELL-EPIRELAERYAAARERLAELEYLRAAL-----RL 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1676 KQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLM---------------LEEELRNLRLEYDDLRRGRSE 1740
Cdd:COG4913  284 WFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDEleaqirgnggdrleqLEREIERLERELEERERRRAR 363

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1741 ADsdknatilELRSQLQISNNRTLE-LQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKI 1819
Cdd:COG4913  364 LE--------ALLAALGLPLPASAEeFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRK 435

                        250       260
                 ....*....|....*....|
gi 1147813  1820 KVLEqdkARLQRLEDELNRA 1839
Cdd:COG4913  436 SNIP---ARLLALRDALAEA 452
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 824-1492 1.30e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 54.20  E-value: 1.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     824 LLATMKTELQKAQQIHSQTSQQyplydldlgkfgEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWL- 902
Cdd:TIGR00618  227 ELKHLREALQQTQQSHAYLTQK------------REAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAp 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     903 ------------YDRKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRD-----KSEEVQKIAELCANSIKDYELQL 965
Cdd:TIGR00618  295 laahikavtqieQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLlqtlhSQEIHIRDAHEVATSIREISCQQ 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     966 ASYTSGLETLL-NIPIKRTMIQSPSGVILQEAADVHARYIELLTRS---GDYYRFLSEMLKSLEDLKLKNTKIEVLEEEL 1041
Cdd:TIGR00618  375 HTLTQHIHTLQqQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRdlqGQLAHAKKQQELQQRYAELCAAAITCTAQCE 454

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1042 RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLAslEELKRQAELdgksaKQNLDKCYGQIKELNEKITrLTYEIEDE 1121
Cdd:TIGR00618  455 KLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKA--VVLARLLEL-----QEEPCPLCGSCIHPNPARQ-DIDNPGPL 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1122 KRRRKSVEDRfdqqkndYDQLQKarqcEKENLGWQKLESEKAIKEkeyeierlrvlLQEEGTRKREYENELAKVRNHYNE 1201
Cdd:TIGR00618  527 TRRMQRGEQT-------YAQLET----SEEDVYHQLTSERKQRAS-----------LKEQMQEIQQSFSILTQCDNRSKE 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1202 EMSNLRnkyeteiNITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRR-----RAEENALQ 1276
Cdd:TIGR00618  585 DIPNLQ-------NITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKltalhALQLTLTQ 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1277 QK---ACGSEIMQKKQHLEIELK--QVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE------EAKRRWEYE 1345
Cdd:TIGR00618  658 ERvreHALSIRVLPKELLASRQLalQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEienassSLGSDLAAR 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1346 NE-LSKVRNNYDEEI-ISLKNQ-FETEINITKTTIHQLTMQKEEDTSGyraqidNLTRENRSLSEEIKRLKNTLTQTTEN 1422
Cdd:TIGR00618  738 EDaLNQSLKELMHQArTVLKARtEAHFNNNEEVTAALQTGAELSHLAA------EIQFFNRLREEDTHLLKTLEAEIGQE 811

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1423 LrrvEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQsLDDAAKTIQDKNKEIERLKQLIDK 1492
Cdd:TIGR00618  812 I---PSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLK-YEECSKQLAQLTQEQAKIIQLSDK 877
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1385-1944 1.42e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 54.21  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1385 EEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKAtgSEVSQRKQQLEVELRQVTQMRTEESVR 1464
Cdd:pfam02463  159 EEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKA--LEYYQLKEKLELEEEYLLYLDYLKLNE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1465 YKQSLDDaaKTIQDKNKEIERLKQLIDKET---NDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRID 1541
Cdd:pfam02463  237 ERIDLLQ--ELLRDEQEEIESSKQEIEKEEeklAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEE 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1542 YERVSQERTVKDQD--------ITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKit 1613
Cdd:pfam02463  315 KLKESEKEKKKAEKelkkekeeIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKL-- 392

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1614 nLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQR------TQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQK 1687
Cdd:pfam02463  393 -KEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEeleileEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1688 AI--EDKSRSLNESKIEIERLQSLTENLTKEhLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLE 1765
Cdd:pfam02463  472 DLlkETQLVKLQEQLELLLSRQKLEERSQKE-SKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVI 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1766 LQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEA 1845
Cdd:pfam02463  551 VEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILK 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1846 ETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQ 1925
Cdd:pfam02463  631 DTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKE 710

                          570
                   ....*....|....*....
gi 1147813    1926 SQLETERSRYQREIDKLRQ 1944
Cdd:pfam02463  711 ELKKLKLEAEELLADRVQE 729
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1541-1945 1.65e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 54.19  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1541 DYERVSQERTVKDQDITRFQNSLkeLQLQKQKVEEE--LNRLKRTASEDSCKRKKLEEELEGMRRSLK------EQAIKI 1612
Cdd:COG3096  272 DYMRHANERRELSERALELRREL--FGARRQLAEEQyrLVEMARELEELSARESDLEQDYQAASDHLNlvqtalRQQEKI 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1613 TNLTQQLEQAsivkkrsEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI--- 1689
Cdd:COG3096  350 ERYQEDLEEL-------TERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVqal 422

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1690 EDKSRSLNESKIEIE-----------RLQSLTENL--TKEHLMLEEELRN-LRLEYDDLRR-----GRSEADSDKNATIL 1750
Cdd:COG3096  423 EKARALCGLPDLTPEnaedylaafraKEQQATEEVleLEQKLSVADAARRqFEKAYELVCKiagevERSQAWQTARELLR 502

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1751 ELRSQ-LQISNNRTLELQglindLQRERENLRQeiekfQKQALEASNRIQESKNQCTQVVQERESLlvkikvLEQDKARL 1829
Cdd:COG3096  503 RYRSQqALAQRLQQLRAQ-----LAELEQRLRQ-----QQNAERLLEEFCQRIGQQLDAAEELEEL------LAELEAQL 566

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1830 QRLEDELNRAkstleaetrVKQRLECEKQQIQndLNQWKTQYSRKEEAIRKiesereksereknslrseierLQAEIKRI 1909
Cdd:COG3096  567 EELEEQAAEA---------VEQRSELRQQLEQ--LRARIKELAARAPAWLA---------------------AQDALERL 614

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 1147813  1910 EERCRRKLEDS---TRETQSQLETERSrYQREIDKLRQR 1945
Cdd:COG3096  615 REQSGEALADSqevTAAMQQLLERERE-ATVERDELAAR 652
PLEC smart00250
Plectin repeat;
2251-2288 2.48e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.32  E-value: 2.48e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2251 KDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTA 2288
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 1500-1861 2.63e-06

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 52.77  E-value: 2.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1500 LEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLridyervSQE-RTVKDQ-DITRFQN---SLKELQLQ--KQK 1572
Cdd:pfam05622   71 LQEENFRLETARDDYRIKCEELEKEVLELQHRNEELTSL-------AEEaQALKDEmDILRESSdkvKKLEATVEtyKKK 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1573 VEEeLNRLKRTAsedsckrKKLEEE-LEGMRR--SLKEQAIKITNLTQQLEqasiVKKRSEDDLRQQrdvLDGHLREKQR 1649
Cdd:pfam05622  144 LED-LGDLRRQV-------KLLEERnAEYMQRtlQLEEELKKANALRGQLE----TYKRQVQELHGK---LSEESKKADK 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1650 TQEELRRLSSEVEALRRQ---LLQEQESVKQAH--LRNEHFQkaiedkSRSLNESKIEIERLQSLTENLTKEHLMLE--E 1722
Cdd:pfam05622  209 LEFEYKKLEEKLEALQKEkerLIIERDTLRETNeeLRCAQLQ------QAELSQADALLSPSSDPGDNLAAEIMPAEirE 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1723 ELRNLRLEYDDLRRGRSEADSDK-----------NATILELRSQLQISNNRTLELQGLINDLQRERE----------NLR 1781
Cdd:pfam05622  283 KLIRLQHENKMLRLGQEGSYRERltelqqlledaNRRKNELETQNRLANQRILELQQQVEELQKALQeqgskaedssLLK 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1782 QEIEKFQKQALEASNRIQESKNQctqvVQERE-----SLLVKIKVLEqdkARLQRLEDELnrakstLEAETRVKQRLECE 1856
Cdd:pfam05622  363 QKLEEHLEKLHEAQSELQKKKEQ----IEELEpkqdsNLAQKIDELQ---EALRKKDEDM------KAMEERYKKYVEKA 429


                   ....*
gi 1147813    1857 KQQIQ 1861
Cdd:pfam05622  430 KSVIK 434
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1223-1795 2.78e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 53.30  E-value: 2.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1223 EISMQKEDD--SKNLRNQLDRLSRENRDLKDE----IVRLNDSILQATEQRRRAEENALQQKACGSEimQKKQHLEiELK 1296
Cdd:pfam12128  274 IASRQEERQetSAELNQLLRTLDDQWKEKRDElngeLSAADAAVAKDRSELEALEDQHGAFLDADIE--TAAADQE-QLP 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1297 QVMQQRSEDNARHK------QSLEEA-----AKTIQDKNKEIERLKaefQEEAKRRWEYENELSKVRNNYDeeiiSLKNQ 1365
Cdd:pfam12128  351 SWQSELENLEERLKaltgkhQDVTAKynrrrSKIKEQNNRDIAGIK---DKLAKIREARDRQLAVAEDDLQ----ALESE 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1366 FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLS------EEIKRLKNTLTQTTENLRRVEEDIQQQKATGSE 1439
Cdd:pfam12128  424 LREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLqlenfdERIERAREEQEAANAEVERLQSELRQARKRRDQ 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1440 VSQRKQQLEVELRQVTQMRTEesvrYKQSLDDAAKT-IQDKNKEI----ERLKQLIDKETNDRKCLEDE--------NAR 1506
Cdd:pfam12128  504 ASEALRQASRRLEERQSALDE----LELQLFPQAGTlLHFLRKEApdweQSIGKVISPELLHRTDLDPEvwdgsvggELN 579

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1507 LQRVQYDLQKANssatetINKLKVQEQELTRLRIDYERVSQERTVKDQDITRfQNSLKELQLQKQKVEEELNRLKRTASE 1586
Cdd:pfam12128  580 LYGVKLDLKRID------VPEWAASEEELRERLDKAEEALQSAREKQAAAEE-QLVQANGELEKASREETFARTALKNAR 652

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1587 DSCKRKKLEEELEGMR--RSLKE-QAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEA 1663
Cdd:pfam12128  653 LDLRRLFDEKQSEKDKknKALAErKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLA 732

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1664 LRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKI-----EIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGR 1738
Cdd:pfam12128  733 LLKAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIaklkrEIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPRL 812

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813    1739 SEADSDKNATILELRSQlqisnnrtleLQGLINDLQRERENLRQEIEKFQKQALEAS 1795
Cdd:pfam12128  813 ATQLSNIERAISELQQQ----------LARLIADTKLRRAKLEMERKASEKQQVRLS 859
mukB PRK04863
chromosome partition protein MukB;
1629-1945 3.21e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 53.04  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1629 SEDDLRQQRDVLDGHlREKQRTQEELRRLSSEVEAL--RRQLLQEQESVKQAHLR----NEHFQKAIEDKSRSLNESKIE 1702
Cdd:PRK04863  285 LEEALELRRELYTSR-RQLAAEQYRLVEMARELAELneAESDLEQDYQAASDHLNlvqtALRQQEKIERYQADLEELEER 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1703 IERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRseADSDKNATILELR-SQLQISNNRTLELQGLINDLQRERENLR 1781
Cdd:PRK04863  364 LEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQL--ADYQQALDVQQTRaIQYQQAVQALERAKQLCGLPDLTADNAE 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1782 QEIEKFQKQALEASNRI----------QESKNQCTQVVQ---------ERE-------SLLVKIKVLEQDKARLQRLEDE 1835
Cdd:PRK04863  442 DWLEEFQAKEQEATEELlsleqklsvaQAAHSQFEQAYQlvrkiagevSRSeawdvarELLRRLREQRHLAEQLQQLRMR 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1836 LNRAKSTLEAETRVKQRL-ECEKQQIQNDLNQWKTQ--YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE-- 1910
Cdd:PRK04863  522 LSELEQRLRQQQRAERLLaEFCKRLGKNLDDEDELEqlQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAar 601

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1147813   1911 ---------------ERCRRKLEDSTRET---QSQLETERSrYQREIDKLRQR 1945
Cdd:PRK04863  602 apawlaaqdalarlrEQSGEEFEDSQDVTeymQQLLERERE-LTVERDELAAR 653
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1063-1926 3.39e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 53.13  E-value: 3.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1063 QKYQAECSQFKAKLASLeelKRQAELDGKSAKQNLDKCYGQIKELNEKITRLtyEIEDEKRRRKSVEDRFDQQKNDYDQL 1142
Cdd:TIGR01612  667 KIYEDDIDALYNELSSI---VKENAIDNTEDKAKLDDLKSKIDKEYDKIQNM--ETATVELHLSNIENKKNELLDIIVEI 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1143 QKARQCEKENLGWQKLESekaIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMS-------NLRNKYETEIN 1215
Cdd:TIGR01612  742 KKHIHGEINKDLNKILED---FKNKEKELSNKINDYAKEKDELNKYKSKISEIKNHYNDQINidnikdeDAKQNYDKSKE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1216 ITKT----------TIKEISMQKED--DSKNLRNQLDRLSRENRD------------LKDEIV---------RLNDSILQ 1262
Cdd:TIGR01612  819 YIKTisikedeifkIINEMKFMKDDflNKVDKFINFENNCKEKIDseheqfaeltnkIKAEISddklndyekKFNDSKSL 898

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1263 ATEQRRRAEE-----NALQQ-----KACGS--EIMQKKQHLEIELKQVMQQR----SEDNARHKQSLEEAAKTIQDKNKE 1326
Cdd:TIGR01612  899 INEINKSIEEeyqniNTLKKvdeyiKICENtkESIEKFHNKQNILKEILNKNidtiKESNLIEKSYKDKFDNTLIDKINE 978

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1327 IERLkaeFQEEAKRRWEYE-NELSKVRNNYDEEI-----ISLKNQFETEINITKTTIhqltmQKEEDTSGYRAQIDNLTR 1400
Cdd:TIGR01612  979 LDKA---FKDASLNDYEAKnNELIKYFNDLKANLgknkeNMLYHQFDEKEKATNDIE-----QKIEDANKNIPNIEIAIH 1050

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1401 EN-RSLSEEIKRL--KNTLTQTTENLRRVEEDI--------------------QQQKATGSEVSQRK-------QQLEVE 1450
Cdd:TIGR01612 1051 TSiYNIIDEIEKEigKNIELLNKEILEEAEINItnfneikeklkhynfddfgkEENIKYADEINKIKddiknldQKIDHH 1130

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1451 LRQVTQMRT-------EESVRYKQSLDDAAKTIQDKN-KEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSAT 1522
Cdd:TIGR01612 1131 IKALEEIKKksenyidEIKAQINDLEDVADKAISNDDpEEIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKDKTSLE 1210

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1523 ETINKLKVQEQELTRL---RIDYERVSQERTVKDQDitRFQNSLKELQLQKQKVEE----------ELNRLKRTASEDS- 1588
Cdd:TIGR01612 1211 EVKGINLSYGKNLGKLfleKIDEEKKKSEHMIKAME--AYIEDLDEIKEKSPEIENemgiemdikaEMETFNISHDDDKd 1288

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1589 --CKRKKLEEELEGMRrslkEQAIKITNLTQQLEQASIVKKRSEDDLRQ-QRDVLDGHLREKQRTQ-------EELRRLS 1658
Cdd:TIGR01612 1289 hhIISKKHDENISDIR----EKSLKIIEDFSEESDINDIKKELQKNLLDaQKHNSDINLYLNEIANiynilklNKIKKII 1364

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1659 SEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSrSLNESKIEIER----------LQSLTEnlTKEHLMLEEELRNLR 1728
Cdd:TIGR01612 1365 DEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDI-NLEECKSKIEStlddkdidecIKKIKE--LKNHILSEESNIDTY 1441

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1729 LEYDDlrrgrseadsDKNATILELRSQLQISNNRT-----LELQGLINDLQRERENLRQEIEKFQKQALEA-SNRIQESK 1802
Cdd:TIGR01612 1442 FKNAD----------ENNENVLLLFKNIEMADNKSqhilkIKKDNATNDHDFNINELKEHIDKSKGCKDEAdKNAKAIEK 1511

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1803 NQC--TQVVQERESLLVKIKVLE------QDKARLQRLEDELNRAKS--TLEAETRVKQRLECEKQQIQNDLNQWKTQYS 1872
Cdd:TIGR01612 1512 NKElfEQYKKDVTELLNKYSALAiknkfaKTKKDSEIIIKEIKDAHKkfILEAEKSEQKIKEIKKEKFRIEDDAAKNDKS 1591

                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1147813    1873 RKeeAIRKIesereksereknslRSEIERLQAEIKRIEErCRRKLEDSTRETQS 1926
Cdd:TIGR01612 1592 NK--AAIDI--------------QLSLENFENKFLKISD-IKKKINDCLKETES 1628
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1386-1723 3.54e-06

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 51.74  E-value: 3.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1386 EDTSGYRAQIDNLTRENRSLSeeikrlKNTLTQTTEnlRRVEEDIQQQKATGSEVSQRKQQ-LEVELRQVTQMRTEESvr 1464
Cdd:pfam15905   24 EKSQRFRKQKAAESQPNLNNS------KDASTPATA--RKVKSLELKKKSQKNLKESKDQKeLEKEIRALVQERGEQD-- 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1465 ykqslddaaKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANS------SATETINKLKVQEQELTRL 1538
Cdd:pfam15905   94 ---------KRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNEllkakfSEDGTQKKMSSLSMELMKL 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1539 RIDYERVSQERTVKDQDIT-RFQNSLKELQLQKQKV---EEELNRLKRTASEDSCKRKKLEEELEgmrrslkeqaiKITN 1614
Cdd:pfam15905  165 RNKLEAKMKEVMAKQEGMEgKLQVTQKNLEHSKGKVaqlEEKLVSTEKEKIEEKSETEKLLEYIT-----------ELSC 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1615 LTQQLEQASIVKKRSEDDLRQQRDvldghlrekqrtqeELRRLSSEVEAlrrqllQEQESVKQAHLRNEHFQKAIEDKSR 1694
Cdd:pfam15905  234 VSEQVEKYKLDIAQLEELLKEKND--------------EIESLKQSLEE------KEQELSKQIKDLNEKCKLLESEKEE 293

                          330       340
                   ....*....|....*....|....*....
gi 1147813    1695 SLNESKIEIERLQSLTENLtKEHLMLEEE 1723
Cdd:pfam15905  294 LLREYEEKEQTLNAELEEL-KEKLTLEEQ 321
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 727-1412 3.75e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 52.66  E-value: 3.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     727 KDMLANFRGSEKYCYLQNEVFGLFQKLE-NINGVTDGY-LNSLCTVrallQAILQTEDMLKVYEARLTEEETVCLDLDKV 804
Cdd:TIGR00618  166 KELLMNLFPLDQYTQLALMEFAKKKSLHgKAELLTLRSqLLTLCTP----CMPDTYHERKQVLEKELKHLREALQQTQQS 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     805 EAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPlyDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ 884
Cdd:TIGR00618  242 HAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQE--RINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSK 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     885 IKQLRNYRDNYQAFCKWLYDRKRRQDSLESMkFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELcANSIKDYELQ 964
Cdd:TIGR00618  320 MRSRAKLLMKRAAHVKQQSSIEEQRRLLQTL-HSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQ-KTTLTQKLQS 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813     965 LASYTSGLETLLNIPIKRTMIQSP----------SGVILQEAADVHARYIE-----------LLTRSGDYYRFLSEMLKS 1023
Cdd:TIGR00618  398 LCKELDILQREQATIDTRTSAFRDlqgqlahakkQQELQQRYAELCAAAITctaqceklekiHLQESAQSLKEREQQLQT 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1024 LEDLKLKNTKIEVLEEElRLARDANSENCNKNKFLDQNLQKYQAECSQ-FKAKLASLEELKRQAELDGKSAKQNLDKCYG 1102
Cdd:TIGR00618  478 KEQIHLQETRKKAVVLA-RLLELQEEPCPLCGSCIHPNPARQDIDNPGpLTRRMQRGEQTYAQLETSEEDVYHQLTSERK 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1103 QIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEeg 1182
Cdd:TIGR00618  557 QRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHL-- 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1183 trkREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQ----KEDDSKNLRNQLDRLsRENRDLKDEIVRLND 1258
Cdd:TIGR00618  635 ---QQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLAsrqlALQKMQSEKEQLTYW-KEMLAQCQTLLRELE 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1259 SILQatEQRRRAEENALQQKACGSEIMQKK-------QHLEIELKQVMQQRSEDNARHKQS----------LEEAAKTIQ 1321
Cdd:TIGR00618  711 THIE--EYDREFNEIENASSSLGSDLAAREdalnqslKELMHQARTVLKARTEAHFNNNEEvtaalqtgaeLSHLAAEIQ 788

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1322 DKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGyRAQIDNLTRE 1401
Cdd:TIGR00618  789 FFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEEC-SKQLAQLTQE 867

                          730
                   ....*....|.
gi 1147813    1402 NRSLSEEIKRL 1412
Cdd:TIGR00618  868 QAKIIQLSDKL 878
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1592-1945 4.01e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.67  E-value: 4.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1592 KKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLR-QQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQ 1670
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEyYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1671 EQEsvKQAHLRNEhfQKAIEDKSRSLNESKIEIERLQSLTEnltKEHLMLEEELRNLRLEYDDLRRgrseadsdknaTIL 1750
Cdd:pfam02463  249 EQE--EIESSKQE--IEKEEEKLAQVLKENKEEEKEKKLQE---EELKLLAKEEEELKSELLKLER-----------RKV 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ 1830
Cdd:pfam02463  311 DDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAA 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1831 RLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQwktqysrKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1910
Cdd:pfam02463  391 KLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKK-------EELEILEEEEESIELKQGKLTEEKEELEKQELKLLKD 463

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1147813    1911 ERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:pfam02463  464 ELELKKSEDLLKETQLVKLQEQLELLLSRQKLEER 498
mukB PRK04863
chromosome partition protein MukB;
1227-1911 4.50e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 52.65  E-value: 4.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1227 QKEDDSKNLRNQLDRLSRENRDLKDEIVRlNDSILQATEQRRRAEEnalqQKACGSEIMQKKQHLEiELKQVMQQRsedn 1306
Cdd:PRK04863  463 QKLSVAQAAHSQFEQAYQLVRKIAGEVSR-SEAWDVARELLRRLRE----QRHLAEQLQQLRMRLS-ELEQRLRQQ---- 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1307 arhkqsleeaaktiqdknKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINiTKTTIHQLTMQKEE 1386
Cdd:PRK04863  533 ------------------QRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARE-RRMALRQQLEQLQA 593

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1387 DTSGYRAQidnlTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQ-------KATGSEVSQRKQQLEVELRQVTQMRT 1459
Cdd:PRK04863  594 RIQRLAAR----APAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLlererelTVERDELAARKQALDEEIERLSQPGG 669

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1460 EESVRYKQ-----------------SLDDA------------AKTIQDKNKEIERLKQLIDketndrkCLEDenarLQRV 1510
Cdd:PRK04863  670 SEDPRLNAlaerfggvllseiyddvSLEDApyfsalygparhAIVVPDLSDAAEQLAGLED-------CPED----LYLI 738

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1511 QYDLQKANSSAtetinkLKVQEQE---LTRLRIDYERVSQERTVKdqditRF-----QNSLKELQLQKQKVEEELNrlkr 1582
Cdd:PRK04863  739 EGDPDSFDDSV------FSVEELEkavVVKIADRQWRYSRFPEVP-----LFgraarEKRIEQLRAEREELAERYA---- 803

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1583 TASEDSCKRKKLEEELE---GMRRSLK-----EQAIKitnltqqleqasivkkrsedDLRQQRDVLDGHLrekQRTQEEL 1654
Cdd:PRK04863  804 TLSFDVQKLQRLHQAFSrfiGSHLAVAfeadpEAELR--------------------QLNRRRVELERAL---ADHESQE 860

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1655 RRLSSEVEALRRQLLQEQESVKQAH-LRNEHFQK---AIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNlrle 1730
Cdd:PRK04863  861 QQQRSQLEQAKEGLSALNRLLPRLNlLADETLADrveEIREQLDEAEEAKRFVQQHGNALAQLEPIVSVLQSDPEQ---- 936

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1731 YDDLRRGRSEADSDKNATILELRSQLQISNNRT----LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCT 1806
Cdd:PRK04863  937 FEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAhfsyEDAAEMLAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLA 1016

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1807 QVVQERESLLVKIKVLEQDKARLQRLEDELN-RAKSTLEAETRVKQRlecekqQIQNDLNqwkTQYSRKEEAIRKIEser 1885
Cdd:PRK04863 1017 QYNQVLASLKSSYDAKRQMLQELKQELQDLGvPADSGAEERARARRD------ELHARLS---ANRSRRNQLEKQLT--- 1084

                         730       740
                  ....*....|....*....|....*.
gi 1147813   1886 eksereknSLRSEIERLQAEIKRIEE 1911
Cdd:PRK04863 1085 --------FCEAEMDNLTKKLRKLER 1102
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1229-1932 4.94e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.53  E-value: 4.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1229 EDDSKNLRNQLDRLSRENRDLKDEIVRLndsilqATEQRRRAEENAlqqkacgseimQKKQHLEIELKQVMQQRSEDNAR 1308
Cdd:pfam12128  247 QQEFNTLESAELRLSHLHFGYKSDETLI------ASRQEERQETSA-----------ELNQLLRTLDDQWKEKRDELNGE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1309 hkqsLEEAAKTIQDKNKEIERLkaefqEEAKRRWEYENeLSKVRNNYDEEiislkNQFETEINITKTTIHQLTMQKEEDT 1388
Cdd:pfam12128  310 ----LSAADAAVAKDRSELEAL-----EDQHGAFLDAD-IETAAADQEQL-----PSWQSELENLEERLKALTGKHQDVT 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1389 SGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKAtgsevSQRKQQLEVELRQVTqmrtEESVRYKQS 1468
Cdd:pfam12128  375 AKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDLQALE-----SELREQLEAGKLEFN----EEEYRLKSR 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1469 LDDAAKTIQDKNKEIErlkQLIDKETNDRKC------LEDENARLQRVQYDLQKANssatetinklKVQEQELTRLRIDY 1542
Cdd:pfam12128  446 LGELKLRLNQATATPE---LLLQLENFDERIerareeQEAANAEVERLQSELRQAR----------KRRDQASEALRQAS 512

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1543 ERVSQERT----VKDQDITRFQNSLKELQLQKQKVEEELNRLkrtASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQ 1618
Cdd:pfam12128  513 RRLEERQSaldeLELQLFPQAGTLLHFLRKEAPDWEQSIGKV---ISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKR 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1619 LEQASIVKkrSEDDLRQQRDVLDGHL---REKQRTQEE-LRRLSSEVEALRRqllqEQESVKQAhlrnehFQKAIEDKSR 1694
Cdd:pfam12128  590 IDVPEWAA--SEEELRERLDKAEEALqsaREKQAAAEEqLVQANGELEKASR----EETFARTA------LKNARLDLRR 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1695 SLNESKIEIERLQsltENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISnnrtleLQGLINDLQ 1774
Cdd:pfam12128  658 LFDEKQSEKDKKN---KALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAY------WQVVEGALD 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1775 RERENLRQEIEKFQKQAleasnriqesKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRaksTLEAETRVKQRLE 1854
Cdd:pfam12128  729 AQLALLKAAIAARRSGA----------KAELKALETWYKRDLASLGVDPDVIAKLKREIRTLER---KIERIAVRRQEVL 795

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813    1855 CEKQQIQNdlnQWKTQYSRKEEAIRKIesereksereknslRSEIERLQAEIKRIEERCRRKLedstretqSQLETER 1932
Cdd:pfam12128  796 RYFDWYQE---TWLQRRPRLATQLSNI--------------ERAISELQQQLARLIADTKLRR--------AKLEMER 848
PRK12704 PRK12704
phosphodiesterase; Provisional
 1160-1341 5.52e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 51.70  E-value: 5.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1160 SEKAIKEKEYEIERLrvlLQEEgtrKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQL 1239
Cdd:PRK12704   29 AEAKIKEAEEEAKRI---LEEA---KKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1240 DRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHleiELKQVMQQRSEDNARHkqsleEAAKT 1319
Cdd:PRK12704  103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE---EAKEILLEKVEEEARH-----EAAVL 174

                         170       180
                  ....*....|....*....|..
gi 1147813   1320 IqdknKEIErlkAEFQEEAKRR 1341
Cdd:PRK12704  175 I----KEIE---EEAKEEADKK 189
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1103-1347 6.72e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.30  E-value: 6.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1103 QIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQcekenlgwqklESEKAIKEKEYEIERLRVLLQEEG 1182
Cdd:COG4942   28 ELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIR-----------ALEQELAALEAELAELEKEIAELR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1183 TRKREYENELAKVrnhyneemsnLRNKYETEINitkTTIKEISMQkeDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQ 1262
Cdd:COG4942   97 AELEAQKEELAEL----------LRALYRLGRQ---PPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1263 ATEQRRRAEENALQQKACGSEIMQKKQhleiELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW 1342
Cdd:COG4942  162 LAALRAELEAERAELEALLAELEEERA----ALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237


                 ....*
gi 1147813  1343 EYENE 1347
Cdd:COG4942  238 AAAER 242
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1056-1364 7.16e-06

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 51.50  E-value: 7.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1056 KFLDQNLQKYQAECSQFKAKLASLEELKRQ-AELDGKSAKQNLDKcygqIKELNEKITRLTYEIEDEKRR-RKSVEDRFD 1133
Cdd:COG5185  232 EEALKGFQDPESELEDLAQTSDKLEKLVEQnTDLRLEKLGENAES----SKRLNENANNLIKQFENTKEKiAEYTKSIDI 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1134 QQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNhyNEEMSNLRNKYETE 1213
Cdd:COG5185  308 KKATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVE--LSKSSEELDSFKDT 385

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1214 INitkTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQhlEI 1293
Cdd:COG5185  386 IE---STKESLDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMREAD--EE 460

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1147813  1294 ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEakrRWEYENELSKVRNNYDEEIISLKN 1364
Cdd:COG5185  461 SQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKL---RAKLERQLEGVRSKLDQVAESLKD 528
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1466-1761 7.38e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 51.06  E-value: 7.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1466 KQSLDDAAKTIQDKNKEIERLKQLIDKETNDrkcLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERV 1545
Cdd:COG4372   30 SEQLRKALFELDKLQEELEQLREELEQAREE---LEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1546 SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIV 1625
Cdd:COG4372  107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALD 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1626 KKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIER 1705
Cdd:COG4372  187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 1147813  1706 LQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNN 1761
Cdd:COG4372  267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALL 322
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1594-1945 7.80e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.69  E-value: 7.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1594 LEEELEGMRRSL-KEQAIKITNLTQQLEQasivkkrseddLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQL--LQ 1670
Cdd:COG4717   47 LLERLEKEADELfKPQGRKPELNLKELKE-----------LEEELKEAEEKEEEYAELQEELEELEEELEELEAELeeLR 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1671 EQESVKQAHLRNEHFQKAIEDKSRSLNEskiEIERLQSLTENLtKEHLMLEEELRNLRLEYDDLRRgrsEADSDKNATIL 1750
Cdd:COG4717  116 EELEKLEKLLQLLPLYQELEALEAELAE---LPERLEELEERL-EELRELEEELEELEAELAELQE---ELEELLEQLSL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKfQKQALEASNRIQESKNQCTQVVQERESLLV--KIKVLEQDKAR 1828
Cdd:COG4717  189 ATEEELQDLAEELEELQQRLAELEEELEEAQEELEE-LEEELEQLENELEAAALEERLKEARLLLLIaaALLALLGLGGS 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1829 LQRLEDE------------------LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1890
Cdd:COG4717  268 LLSLILTiagvlflvlgllallfllLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIE 347

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813  1891 EKNSLRSEIERL--QAEIKRIEERCRRKLEDSTRETQSQLEtERSRYQREIDKLRQR 1945
Cdd:COG4717  348 ELQELLREAEELeeELQLEELEQEIAALLAEAGVEDEEELR-AALEQAEEYQELKEE 403
PLEC smart00250
Plectin repeat;
2365-2400 9.21e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 9.21e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1147813     2365 IRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEE 2400
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
mukB PRK04863
chromosome partition protein MukB;
1681-1945 1.02e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 51.50  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1681 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTK---EHLML------EEELRnlrleydDLRRGRSEAD---SDKNAT 1748
Cdd:PRK04863  787 RIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRfigSHLAVafeadpEAELR-------QLNRRRVELEralADHESQ 859

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1749 ILELRSQLQISNNRTLELQGLI--------NDLQRERENLRQEIEkfqkQALEASNRIQESKNQCTQVVQERESLLVKIK 1820
Cdd:PRK04863  860 EQQQRSQLEQAKEGLSALNRLLprlnlladETLADRVEEIREQLD----EAEEAKRFVQQHGNALAQLEPIVSVLQSDPE 935

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1821 VLEQDKARLQRLEDELNRAKSTLEAETRVKQR------------LECEKQ---QIQNDLNQWKTQYSRKEEAIRKIESER 1885
Cdd:PRK04863  936 QFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRrahfsyedaaemLAKNSDlneKLRQRLEQAEQERTRAREQLRQAQAQL 1015

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1886 EKSEREKNSLRSEIERLQ---AEIKR------------IEERCRRKLED------STRETQSQLETERSRYQREIDKLRQ 1944
Cdd:PRK04863 1016 AQYNQVLASLKSSYDAKRqmlQELKQelqdlgvpadsgAEERARARRDElharlsANRSRRNQLEKQLTFCEAEMDNLTK 1095


                  .
gi 1147813   1945 R 1945
Cdd:PRK04863 1096 K 1096
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1058-1266 1.03e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.53  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1058 LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
Cdd:COG4942   25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1138 DYDQ----LQKARQCEKENLGWQKLESEKAIKEKEY----------EIERLRVLLQEEGTRKREYENELAKVRNHYnEEM 1203
Cdd:COG4942  105 ELAEllraLYRLGRQPPLALLLSPEDFLDAVRRLQYlkylaparreQAEELRADLAELAALRAELEAERAELEALL-AEL 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1147813  1204 SNLRNKYETEINITKTTIKEISMQKeddsKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQ 1266
Cdd:COG4942  184 EEERAALEALKAERQKLLARLEKEL----AELAAELAELQQEAEELEALIARLEAEAAAAAER 242
PLEC smart00250
Plectin repeat;
2463-2493 1.20e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 1.20e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1147813     2463 KRRVVIVDPETNKEMSVQEAYKKGLIDYETF 2493
Cdd:smart00250    8 SAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1018-1357 1.58e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 50.81  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1018 SEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNL 1097
Cdd:PRK02224  370 SELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALL 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1098 D--KC--YGQ----------IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKndydQLQKARQcEKENLGWQKLESEKA 1163
Cdd:PRK02224  450 EagKCpeCGQpvegsphvetIEEDRERVEELEAELEDLEEEVEEVEERLERAE----DLVEAED-RIERLEERREDLEEL 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1164 IKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYET--EINITKTTIKEISMQKE------DDSKNL 1235
Cdd:PRK02224  525 IAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEvaELNSKLAELKERIESLErirtllAAIADA 604

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1236 RNQLDRLsRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACgSEIMQKKQHLEIELKQVMQQRSEdnarhkqsLEE 1315
Cdd:PRK02224  605 EDEIERL-REKREALAELNDERRERLAEKRERKRELEAEFDEARI-EEAREDKERAEEYLEQVEEKLDE--------LRE 674

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1147813   1316 AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDE 1357
Cdd:PRK02224  675 ERDDLQAEIGAVENELEELEELRERREALENRVEALEALYDE 716
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1367-1575 1.60e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.83  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1367 ETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKAtgsEVSQR 1443
Cdd:COG3883   15 DPQIQAKQKELSELQAELeaaQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERRE---ELGER 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1444 KQQLEVELRQVTQMrteESVRYKQSLDD------AAKTIQDKNKE-IERLKQLIDKETNDRKCLEDENARLQRVQYDLQK 1516
Cdd:COG3883   92 ARALYRSGGSVSYL---DVLLGSESFSDfldrlsALSKIADADADlLEELKADKAELEAKKAELEAKLAELEALKAELEA 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813  1517 ANSSATETINKlkvQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEE 1575
Cdd:COG3883  169 AKAELEAQQAE---QEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAA 224
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1746-1945 1.75e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.76  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1746 NATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQD 1825
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1826 KARLQRLEDELNRAKSTLEAETRVKQRLEcekqqiQNDLNQWktqySRKEEAIRKIESEREKSErekNSLRSEIERLQAE 1905
Cdd:COG4942   99 LEAQKEELAELLRALYRLGRQPPLALLLS------PEDFLDA----VRRLQYLKYLAPARREQA---EELRADLAELAAL 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 1147813  1906 IKRIEERCRRK--LEDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:COG4942  166 RAELEAERAELeaLLAELEEERAALEALKAERQKLLARLEKE 207
growth_prot_Scy NF041483
polarized growth protein Scy;
1200-1963 1.78e-05

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 50.59  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1200 NEEMSNLRNKYETEINITKTTIKEISMQ----KEDDSKNLRNQLDRLSRENRDLKDEIVRLN-DSILQATEQRRRAEENA 1274
Cdd:NF041483  392 AEEAERIRREAEAEADRLRGEAADQAEQlkgaAKDDTKEYRAKTVELQEEARRLRGEAEQLRaEAVAEGERIRGEARREA 471

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1275 LQQ----KACGSEIMQKKQHLEIELKQVMQQ-----RSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKR-RWEY 1344
Cdd:NF041483  472 VQQieeaARTAEELLTKAKADADELRSTATAeservRTEAIERATTLRRQAEETLERTRAEAERLRAEAEEQAEEvRAAA 551

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1345 ENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENrslSEEIKRLKntlTQTTENLR 1424
Cdd:NF041483  552 ERAARELREETERAIAARQAEAAEELTRLHTEAEERLTAAEEALADARAEAERIRREA---AEETERLR---TEAAERIR 625

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1425 rveeDIQQQKATGSEvsqrkqqlevelrqvtQMRTEESVRYKQSLDD----AAKTIQDKNKEIERLKQLIdKETNDRKCL 1500
Cdd:NF041483  626 ----TLQAQAEQEAE----------------RLRTEAAADASAARAEgenvAVRLRSEAAAEAERLKSEA-QESADRVRA 684

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1501 EDENARlQRVQYDLQKANSSAtetinklkvQEQELTRLRIDYERVSQERTVKDQditrfqnslkELQLQKQKVEEELnrl 1580
Cdd:NF041483  685 EAAAAA-ERVGTEAAEALAAA---------QEEAARRRREAEETLGSARAEADQ----------ERERAREQSEELL--- 741

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1581 krtasedSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASivkkrseddlRQQRDVLDGhLREKqrTQEELRRLSSE 1660
Cdd:NF041483  742 -------ASARKRVEEAQAEAQRLVEEADRRATELVSAAEQTA----------QQVRDSVAG-LQEQ--AEEEIAGLRSA 801

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1661 VE----ALRRQLLQEQESVK-QAHLRNEhfqKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDdlR 1735
Cdd:NF041483  802 AEhaaeRTRTEAQEEADRVRsDAYAERE---RASEDANRLRREAQEETEAAKALAERTVSEAIAEAERLRSDASEYA--Q 876

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1736 RGRSEAdSDKNATILElrsqlqisnnrtlelqglinDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESL 1815
Cdd:NF041483  877 RVRTEA-SDTLASAEQ--------------------DAARTRADAREDANRIRSDAAAQADRLIGEATSEAERLTAEARA 935

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1816 LVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQiqndlnqwkTQYSRKEEAIRkiesereksereknsL 1895
Cdd:NF041483  936 EAERLRDEARAEAERVRADAAAQAEQLIAEATGEAERLRAEAAE---------TVGSAQQHAER---------------I 991

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1896 RSEIERLQAEIKRIEERCRR-------KLEDSTRETQS--------QLETERSRYQREIDKLRQRPYGSHRETQTECEWT 1960
Cdd:NF041483  992 RTEAERVKAEAAAEAERLRTeareeadRTLDEARKDANkrrseaaeQADTLITEAAAEADQLTAKAQEEALRTTTEAEAQ 1071


                  ...
gi 1147813   1961 VDT 1963
Cdd:NF041483 1072 ADT 1074
PLEC smart00250
Plectin repeat;
2328-2364 1.80e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.62  E-value: 1.80e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1147813     2328 KLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 2364
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2123-2159 1.80e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.62  E-value: 1.80e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1147813     2123 RLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 2159
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
 1528-1781 1.81e-05

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 49.05  E-value: 1.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1528 LKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKEL----QLQKQKVEEELNRLKRtaSEDSCKRKKLEEELEGMrR 1603
Cdd:pfam17045   37 LDIREEELLSARNTLERKHKEIGLLRQQLEELEKGKQELvakyEQQLQKLQEELSKLKR--SYEKLQRKQLKEAREEA-K 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1604 SLKEQAIKITNLTQQLEQasiVKKRSEDdlrqqrdvldghlREKQRTQEELRRLSSEVEalrRQLLQEQESvkqaHLRNE 1683
Cdd:pfam17045  114 SREEDRSELSRLNGKLEE---FRQKSLE-------------WEQQRLQYQQQVASLEAQ---RKALAEQSS----LIQSA 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1684 HFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLrrgrseadSDKNATILELRSQL-QISNNR 1762
Cdd:pfam17045  171 AYQVQLEGRKQCLEASQSEIQRLRSKLERAQDSLCAQELELERLRMRVSEL--------GDSNRKLLEEQQRLlEELRMS 242

                          250
                   ....*....|....*....
gi 1147813    1763 TLELQGLINDLQRERENLR 1781
Cdd:pfam17045  243 QRQLQVLQNELMELKATLQ 261
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2253-2291 1.96e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 43.86  E-value: 1.96e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1147813    2253 FLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALEL 2291
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1224-1859 2.22e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 50.14  E-value: 2.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1224 ISMQKEDDSKNLRnQLDRLSRENRDLKD---------EIVRLNDSILQATEQRRRAEENALQQKACGSEIMQK--KQHLE 1292
Cdd:pfam07111   61 LSQQAELISRQLQ-ELRRLEEEVRLLREtslqqkmrlEAQAMELDALAVAEKAGQAEAEGLRAALAGAEMVRKnlEEGSQ 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1293 IELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER----LKAEFQEEAKRRWEYENELSKVRNNYDeeiislKNQFET 1368
Cdd:pfam07111  140 RELEEIQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKslnsLETKRAGEAKQLAEAQKEAELLRKQLS------KTQEEL 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1369 EINITKTtihqltmqkeEDTSGYRAQidNLTRENRSLSEEIKRLKntLTQTTENLRRVEEDIQqqkATGSEVSQRKQQLE 1448
Cdd:pfam07111  214 EAQVTLV----------ESLRKYVGE--QVPPEVHSQTWELERQE--LLDTMQHLQEDRADLQ---ATVELLQVRVQSLT 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1449 velrQVTQMRTEESVRYKQSLDDAAKTIQDKNKEI-----ERLKQLIdketndrkcledenarLQRVQYDLQKANSSATE 1523
Cdd:pfam07111  277 ----HMLALQEEELTRKIQPSDSLEPEFPKKCRSLlnrwrEKVFALM----------------VQLKAQDLEHRDSVKQL 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1524 TINKLKVQEQELTRlridyervSQERTV-------KDQDITRFQNSLKELQLQKQKVEEELNRLK-RTASEDSCKR---- 1591
Cdd:pfam07111  337 RGQVAELQEQVTSQ--------SQEQAIlqralqdKAAEVEVERMSAKGLQMELSRAQEARRRQQqQTASAEEQLKfvvn 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1592 --KKLEEELEGMRRSLKEQAIKITNLTQQLEQAS---------IVKKRSEDDLRQQ-------RDVLDGHLR-EKQRTQE 1652
Cdd:pfam07111  409 amSSTQIWLETTMTRVEQAVARIPSLSNRLSYAVrkvhtikglMARKVALAQLRQEscpppppAPPVDADLSlELEQLRE 488

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1653 ELRRLSSEVEALRRQLLQEQesvkqahlrnehfqkaiedkSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732
Cdd:pfam07111  489 ERNRLDAELQLSAHLIQQEV--------------------GRAREQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLE 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1733 DLRRGRSEADSDKNATILELRSQLQISNNRTLE--------LQGLINDLQRERENLRQEiekfQKQALEASNRIQESKNQ 1804
Cdd:pfam07111  549 VARQGQQESTEEAASLRQELTQQQEIYGQALQEkvaevetrLREQLSDTKRRLNEARRE----QAKAVVSLRQIQHRATQ 624

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1147813    1805 CTQVVQERESLlvKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1859
Cdd:pfam07111  625 EKERNQELRRL--QDEARKEEGQRLARRVQELERDKNLMLATLQQEGLLSRYKQQ 677
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1037-1708 2.36e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 50.17  E-value: 2.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE--LKRQAELDGKSAkqNLDKCYGQIKELNEKITRL 1114
Cdd:pfam01576  389 LQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEklSKLQSELESVSS--LLNEAEGKNIKLSKDVSSL 466

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1115 TYEIED-------EKRRRKSVEDRFDQQKNDYDQLQKARQCEKE----------NLGWQKLESEKAIKEKEYEIE----- 1172
Cdd:pfam01576  467 ESQLQDtqellqeETRQKLNLSTRLRQLEDERNSLQEQLEEEEEakrnverqlsTLQAQLSDMKKKLEEDAGTLEaleeg 546

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1173 RLRVLLQEEGTRKREYENELA-----KVRNHYNEEMS----NLRNKYETEINITKTTIKEISMQKEDDSKNLRNQ--LDR 1241
Cdd:pfam01576  547 KKRLQRELEALTQQLEEKAAAydkleKTKNRLQQELDdllvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAeeRDR 626

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1242 LSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHL-----EIE-LKQVMQQRSEDNARHKQSLEE 1315
Cdd:pfam01576  627 AEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVgknvhELErSKRALEQQVEEMKTQLEELED 706

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1316 AAKTIQDKNKEIE----RLKAEFQEEAKRRWEYENELSKvrnnydeEIISLKNQFETEINITKTTIHQLTMQK---EEDT 1388
Cdd:pfam01576  707 ELQATEDAKLRLEvnmqALKAQFERDLQARDEQGEEKRR-------QLVKQVRELEAELEDERKQRAQAVAAKkklELDL 779

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1389 SGYRAQIDNltrENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK---ATGSEVSQRKQQLEVELRQVTQmrteesvry 1465
Cdd:pfam01576  780 KELEAQIDA---ANKGREEAVKQLKKLQAQMKDLQRELEEARASRDeilAQSKESEKKLKNLEAELLQLQE--------- 847

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1466 kqslDDAAKTIQDKNKEIER--LKQLIDKETNDRKCLEDENARLQrvqydlqkanssatetiNKLKVQEQELTRLRIDYE 1543
Cdd:pfam01576  848 ----DLAASERARRQAQQERdeLADEIASGASGKSALQDEKRRLE-----------------ARIAQLEEELEEEQSNTE 906

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1544 RVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRkkleEELEGMRRSLKEQAI-----KITNLTQQ 1618
Cdd:pfam01576  907 LLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKL----QEMEGTVKSKFKSSIaaleaKIAQLEEQ 982

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1619 LEQ-------ASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED 1691
Cdd:pfam01576  983 LEQesrerqaANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDD 1062

                          730
                   ....*....|....*..
gi 1147813    1692 KSRSLNESKIEIERLQS 1708
Cdd:pfam01576 1063 ATESNESMNREVSTLKS 1079
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1743-1936 2.56e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.44  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1743 SDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVV---QERESLLVKI 1819
Cdd:COG3883   26 SELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERAralYRSGGSVSYL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1820 KVLEQDK------ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKN 1893
Cdd:COG3883  106 DVLLGSEsfsdflDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLA 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 1147813  1894 SLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQ 1936
Cdd:COG3883  186 QLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAA 228
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1607-1846 2.61e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.02  E-value: 2.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1607 EQAIKITN-LTQQLEQASIVKKRSEddLRQQRDVLDGHLrekQRTQEELRRLSSEVEALRRQ----LLQEQESVKQAHLR 1681
Cdd:COG3206  148 ELAAAVANaLAEAYLEQNLELRREE--ARKALEFLEEQL---PELRKELEEAEAALEEFRQKnglvDLSEEAKLLLQQLS 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1682 NehFQKAIEDKSRSLNESKIEIERLQSLTENLTKE--HLMLEEELRNLRLEYDDLRRGRSEADS---DKNATILELRSQL 1756
Cdd:COG3206  223 E--LESQLAEARAELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAELEAELAELSArytPNHPDVIALRAQI 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1757 Q-ISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNqctqvvqeresLLVKIKVLEQDKARLQRL-ED 1834
Cdd:COG3206  301 AaLRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPE-----------LEAELRRLEREVEVARELyES 369

                        250
                 ....*....|..
gi 1147813  1835 ELNRAKSTLEAE 1846
Cdd:COG3206  370 LLQRLEEARLAE 381
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1304-1714 2.89e-05

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 49.47  E-value: 2.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1304 EDNARH-----KQSLEEAAKTIQDKNKEIERLKAEFQE----EAKRRWEYE----------NELSKVRNNY-------DE 1357
Cdd:pfam06160   74 ELNDKYrfkkaKKALDEIEELLDDIEEDIKQILEELDEllesEEKNREEVEelkdkyrelrKTLLANRFSYgpaidelEK 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1358 EIISLKNQFETEINITKTTIHqltMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTqttENLRRVEEDIQQQKATG 1437
Cdd:pfam06160  154 QLAEIEEEFSQFEELTESGDY---LEAREVLEKLEEETDALEELMEDIPPLYEELKTELP---DQLEELKEGYREMEEEG 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1438 SEVSQrkQQLEVELRQVTQMRTEESVRYKQ-SLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLqrvqydlqk 1516
Cdd:pfam06160  228 YALEH--LNVDKEIQQLEEQLEENLALLENlELDEAEEALEEIEERIDQLYDLLEKEVDAKKYVEKNLPEI--------- 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1517 anssaTETINKLKVQEQELtrlRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKrtasEDSCKRKKLEE 1596
Cdd:pfam06160  297 -----EDYLEHAEEQNKEL---KEELERVQQSYTLNENELERVRGLEKQLEELEKRYDEIVERLE----EKEVAYSELQE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1597 ELEGMRRSL---KEQAIKITNLTQQLEQasivkkrSEDDLRQQRDVLDGHLREKQRTQEElRRLSSEVEALRRQLLQEQE 1673
Cdd:pfam06160  365 ELEEILEQLeeiEEEQEEFKESLQSLRK-------DELEAREKLDEFKLELREIKRLVEK-SNLPGLPESYLDYFFDVSD 436

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1147813    1674 SVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLT 1714
Cdd:pfam06160  437 EIEDLADELNEVPLNMDEVNRLLDEAQDDVDTLYEKTEELI 477
PTZ00121 PTZ00121
MAEBL; Provisional
 1039-1402 2.96e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEI 1118
Cdd:PTZ00121 1561 EEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKK 1640

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1119 EDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKEnlgwqKLESEKAIKEKEYEIERlrvllQEEGTRKREYENELAKVRNH 1198
Cdd:PTZ00121 1641 KEAEEKKKAEELKKAEEENKIKAAEEAKKAEED-----KKKAEEAKKAEEDEKKA-----AEALKKEAEEAKKAEELKKK 1710

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1199 YNEEMSNLRN-KYETEINITKttIKEISMQKEDDSKNL---------RNQLDRLSRENRDLKDEIVRLNDSIL-----QA 1263
Cdd:PTZ00121 1711 EAEEKKKAEElKKAEEENKIK--AEEAKKEAEEDKKKAeeakkdeeeKKKIAHLKKEEEKKAEEIRKEKEAVIeeeldEE 1788

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1264 TEQRRRAEENALQQKACGSEIMQK------------KQHLEIELKQVM----QQRSEDNARHKQSLEEAAKTIQDKNKEI 1327
Cdd:PTZ00121 1789 DEKRRMEVDKKIKDIFDNFANIIEggkegnlvindsKEMEDSAIKEVAdsknMQLEEADAFEKHKFNKNNENGEDGNKEA 1868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1328 ER-----LKAEFQEEAkrrwEYENELSKVRNNYDEEIISLKNQFETEINITKTTIhQLTMQKEEDTSGYRAQIDNLTREN 1402
Cdd:PTZ00121 1869 DFnkekdLKEDDEEEI----EEADEIEKIDKDDIEREIPNNNMAGKNNDIIDDKL-DKDEYIKRDAEETREEIIKISKKD 1943
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 1578-1793 4.88e-05

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 48.79  E-value: 4.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1578 NRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASivKKRSEDDLRQQRDVLDGHLREKQRTQEELRRL 1657
Cdd:pfam15709  327 KREQEKASRDRLRAERAEMRRLEVERKRREQEEQRRLQQEQLERAE--KMREELELEQQRRFEEIRLRKQRLEEERQRQE 404

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1658 SSEV-EALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYddlRR 1736
Cdd:pfam15709  405 EEERkQRLQLQAAQERARQQQEEFRRKLQELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRLMEMAEEERLEY---QR 481

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813    1737 GRSEAdsdknatilELRSQLQISNNRtlelqglindlQRERENLRQEIEKFQKQALE 1793
Cdd:pfam15709  482 QKQEA---------EEKARLEAEERR-----------QKEEEAARLALEEAMKQAQE 518
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1526-1980 5.26e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 48.97  E-value: 5.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1526 NKLKVQEQELTRLRIDYERvsqERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSL 1605
Cdd:pfam05557   16 NEKKQMELEHKRARIELEK---KASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1606 KEQaikitnlTQQLEQASIVKKRSEDDLRQQRdvldghlREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHF 1685
Cdd:pfam05557   93 NEK-------ESQLADAREVISCLKNELSELR-------RQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1686 QKaiedksrSLNESKIEIERLQSLtenltkehlmleeELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLE 1765
Cdd:pfam05557  159 EK-------QQSSLAEAEQRIKEL-------------EFEIQSQEQDSEIVKNSKSELARIPELEKELERLREHNKHLNE 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1766 LQGLINDLQRERENLRQEIEKFQKQALEASN------RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1839
Cdd:pfam05557  219 NIENKLLLKEEVEDLKRKLEREEKYREEAATlelekeKLEQELQSWVKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEE 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1840 KSTLEAETRVKQR----LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE----- 1910
Cdd:pfam05557  299 NSSLTSSARQLEKarreLEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTMSNyspql 378

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813    1911 ERCRRKLEDSTRETQ---SQLETERSRYQREIDKLRQRPYGSHRETQT----ECEWTVDTSKLVFDGLRKKVTAMQL 1980
Cdd:pfam05557  379 LERIEEAEDMTQKMQahnEEMEAQLSVAEEELGGYKQQAQTLERELQAlrqqESLADPSYSKEEVDSLRRKLETLEL 455
DUF4618 pfam15397
Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins ...
 1557-1716 5.45e-05

Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.


Pssm-ID: 464704 [Multi-domain]  Cd Length: 258  Bit Score: 47.64  E-value: 5.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1557 TRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSL-KE---QAIKITNLTQQLEQASIVKKRSEDD 1632
Cdd:pfam15397   63 KQLQQAKAELQEWEEKEESKLNKLEQQLEQLNAKIQKTQEELNFLSTYKdKEypvKAVQIANLVRQLQQLKDSQQDELDE 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1633 L-RQQRDVLDGHLREKQRTQEELrrLSSEVEalrRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTE 1711
Cdd:pfam15397  143 LeEMRRMVLESLSRKIQKKKEKI--LSSLAE---KTLSPYQESLLQKTRDNQVMLKEIEQFREFIDELEEEIPKLKAEVQ 217


                   ....*
gi 1147813    1712 NLTKE 1716
Cdd:pfam15397  218 QLQAQ 222
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1553-1801 5.68e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 5.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1553 DQDITRFQNSLKELQLQKQKVEEELNrlkrtasedsckrkKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD 1632
Cdd:COG3883   15 DPQIQAKQKELSELQAELEAAQAELD--------------ALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1633 LRQQRDVLDGHLREKQRTQEELRRLSsevealrrqLLQEQESVKQAhLRNEHFQKAIEDKSRSLneskieIERLQSLTEN 1712
Cdd:COG3883   81 IEERREELGERARALYRSGGSVSYLD---------VLLGSESFSDF-LDRLSALSKIADADADL------LEELKADKAE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1713 LTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNatilelrsqlqisnnrtlELQGLINDLQRERENLRQEIEKFQKQAL 1792
Cdd:COG3883  145 LEAKKAELEAKLAELEALKAELEAAKAELEAQQA------------------EQEALLAQLSAEEAAAEAQLAELEAELA 206


                 ....*....
gi 1147813  1793 EASNRIQES 1801
Cdd:COG3883  207 AAEAAAAAA 215
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1553-1738 5.76e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 47.23  E-value: 5.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1553 DQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQAsivkkRSEDD 1632
Cdd:COG1579   16 DSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNV-----RNNKE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1633 LRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQahlRNEHFQKAIEDKSRSLNESKIEIERLQSLTEN 1712
Cdd:COG1579   91 YEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAE---LEAELEEKKAELDEELAELEAELEELEAEREE 167

                        170       180
                 ....*....|....*....|....*.
gi 1147813  1713 LTKEhlmLEEELRNLrleYDDLRRGR 1738
Cdd:COG1579  168 LAAK---IPPELLAL---YERIRKRK 187
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1233-1677 6.42e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.61  E-value: 6.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1233 KNLRNQLDRLSREN----RDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEiELKQVMQQ--RSEDN 1306
Cdd:COG4717   49 ERLEKEADELFKPQgrkpELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELE-ELREELEKleKLLQL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1307 ARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEY---ENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQ 1383
Cdd:COG4717  128 LPLYQELEALEAELAELPERLEELEERLEELRELEEELeelEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQR 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1384 KEEdtsgYRAQIDNLTRENRSLSEEIKRLKNTLtQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVT-------- 1455
Cdd:COG4717  208 LAE----LEEELEEAQEELEELEEELEQLENEL-EAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTiagvlflv 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1456 --------QMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINK 1527
Cdd:COG4717  283 lgllallfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEE 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1528 LKVQEQElTRLRIDYERVSQErtvkdqDITRFQNSLKELQlQKQKVEEELNRLKRtasedsckrkKLEEELEGMRRSLke 1607
Cdd:COG4717  363 LQLEELE-QEIAALLAEAGVE------DEEELRAALEQAE-EYQELKEELEELEE----------QLEELLGELEELL-- 422

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1608 QAIKITNLTQQLEQAsivkKRSEDDLRQQRDVLdghLREKQRTQEELRRLSSEVEAlrRQLLQEQESVKQ 1677
Cdd:COG4717  423 EALDEEELEEELEEL----EEELEELEEELEEL---REELAELEAELEQLEEDGEL--AELLQELEELKA 483
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 1671-1909 6.99e-05

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 47.45  E-value: 6.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1671 EQESVKQAHlrNEHFQKAiedkSRSLnESKieiERL-QSLTENLTKEHLMLEeelRNLRLEYDDLRRGRSEADSDKNATi 1749
Cdd:pfam09787    1 NLESAKQEL--ADYKQKA----ARIL-QSK---EKLiASLKEGSGVEGLDSS---TALTLELEELRQERDLLREEIQKL- 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1750 lelrsQLQISNNRTlELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESL---LVKIKVLEQdk 1826
Cdd:pfam09787   67 -----RGQIQQLRT-ELQELEAQQQEEAESSREQLQELEEQLATERSARREAEAELERLQEELRYLeeeLRRSKATLQ-- 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1827 ARLQRLEDELNRAKSTL-----------EAETRVKQRLECEKQQiQNDLNQWKTQYsrkeeairkieserekserekNSL 1895
Cdd:pfam09787  139 SRIKDREAEIEKLRNQLtsksqssssqsELENRLHQLTETLIQK-QTMLEALSTEK---------------------NSL 196

                          250
                   ....*....|....
gi 1147813    1896 RSEIERLQAEIKRI 1909
Cdd:pfam09787  197 VLQLERMEQQIKEL 210
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1704-1944 7.47e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.47  E-value: 7.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1704 ERLQSLTENLTKehlmLEEELRNLRLEYDdlrrgrseadsdknatILELRSQLQISNNRTLELQGLINDLQRERENLRQE 1783
Cdd:COG3206  182 EQLPELRKELEE----AEAALEEFRQKNG----------------LVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1784 IEKFQKQALEASNRIQESKNQctqvvqeresllvkiKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1863
Cdd:COG3206  242 LAALRAQLGSGPDALPELLQS---------------PVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQ 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1864 LNQwktqysRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIeercrrkledstretqSQLETERSRYQREIDKLR 1943
Cdd:COG3206  307 LQQ------EAQRILASLEAELEALQAREASLQAQLAQLEARLAEL----------------PELEAELRRLEREVEVAR 364


                 .
gi 1147813  1944 Q 1944
Cdd:COG3206  365 E 365
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1513-1761 8.10e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 8.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1513 DLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNrlkrtasedsckrk 1592
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE-------------- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1593 KLEEELEGMRRSLKEQAIKITNLTQQLEQASIvkkrseDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQ 1672
Cdd:COG3883   83 ERREELGERARALYRSGGSVSYLDVLLGSESF------SDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1673 ESVKQAHLRNEHFQKAIEDKsrslneskieIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILEL 1752
Cdd:COG3883  157 AELEALKAELEAAKAELEAQ----------QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAA 226


                 ....*....
gi 1147813  1753 RSQLQISNN 1761
Cdd:COG3883  227 AAAAAAAAA 235
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1019-1287 9.17e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 47.21  E-value: 9.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1019 EMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKfldQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD 1098
Cdd:COG1340    5 ELSSSLEELEEKIEELREEIEELKEKRDELNEELKELA---EKRDELNAQVKELREEAQELREKRDELNEKVKELKEERD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1099 KCYGQIKELNEKITRLTYEIEDEKRRRKSVedrfDQQKNDYDQLQKARQCEKENLGWQK------------LESEKAIKE 1166
Cdd:COG1340   82 ELNEKLNELREELDELRKELAELNKAGGSI----DKLRKEIERLEWRQQTEVLSPEEEKelvekikelekeLEKAKKALE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1167 KEYEIERLRVLLQEEGTRKREYEN---ELAKVRNHYNEEMSNLRNKYET---EINITKTTIKEISmqkeDDSKNLRNQLD 1240
Cdd:COG1340  158 KNEKLKELRAELKELRKEAEEIHKkikELAEEAQELHEEMIELYKEADElrkEADELHKEIVEAQ----EKADELHEEII 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 1147813  1241 RLSRENRDLKDEIVRLNDsilQATEQRRRAEENALQQKAcgSEIMQK 1287
Cdd:COG1340  234 ELQKELRELRKELKKLRK---KQRALKREKEKEELEEKA--EEIFEK 275
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1156-1412 9.27e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 9.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1156 QKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEeMSNLRNKYETEINITKTTIKEismqkeddsknL 1235
Cdd:COG4942   21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAA-LARRIRALEQELAALEAELAE-----------L 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1236 RNQLDRLSRENRDLKDEIVRLndsiLQATEQRRRAEENALQQKACGSEIMQKKQHLeieLKQVMQQRsednarhkqslEE 1315
Cdd:COG4942   89 EKEIAELRAELEAQKEELAEL----LRALYRLGRQPPLALLLSPEDFLDAVRRLQY---LKYLAPAR-----------RE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1316 AAKTIQDKNKEIERLKAEFQEEAKrrweyenELSKVRNNYDEEiislKNQFETEINITKTTIHQLTMQKEEdtsgYRAQI 1395
Cdd:COG4942  151 QAEELRADLAELAALRAELEAERA-------ELEALLAELEEE----RAALEALKAERQKLLARLEKELAE----LAAEL 215

                        250
                 ....*....|....*..
gi 1147813  1396 DNLTRENRSLSEEIKRL 1412
Cdd:COG4942  216 AELQQEAEELEALIARL 232
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1752-1945 9.40e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.09  E-value: 9.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1752 LRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASnrIQESKNQCTQVVQERESLLVKIKV-LEQDKARLQ 1830
Cdd:COG3206  166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVD--LSEEAKLLLQQLSELESQLAEARAeLAEAEARLA 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1831 RLEDELNRAKSTLEA--ETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRkiesereksereknSLRSEIERLQAEIKR 1908
Cdd:COG3206  244 ALRAQLGSGPDALPEllQSPVIQQLRAQLAELEAELAELSARYTPNHPDVI--------------ALRAQIAALRAQLQQ 309

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 1147813  1909 IEERcrrkLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:COG3206  310 EAQR----ILASLEAELEALQAREASLQAQLAQLEAR 342
PLEC smart00250
Plectin repeat;
2611-2647 1.00e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.70  E-value: 1.00e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1147813     2611 DTLEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2647
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1618-1945 1.06e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.91  E-value: 1.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1618 QLEQASIVKKRSEDDLRQ---QRDVLDGHLREKQRTQ-EELRRLSSEVEALRR---------QLLQEQESVKQAHLRNEH 1684
Cdd:pfam12128  183 KIAKAMHSKEGKFRDVKSmivAILEDDGVVPPKSRLNrQQVEHWIRDIQAIAGimkirpeftKLQQEFNTLESAELRLSH 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1685 FQKAIEDKSRslneskiEIERLQSLTENLTKEhlmLEEELRNLRleyDDLRRGRSEADSDK---NATILELRSQLQISNN 1761
Cdd:pfam12128  263 LHFGYKSDET-------LIASRQEERQETSAE---LNQLLRTLD---DQWKEKRDELNGELsaaDAAVAKDRSELEALED 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1762 RTLELQglinDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLvKIKVLEQDKARLQRLEDELNRAKs 1841
Cdd:pfam12128  330 QHGAFL----DADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRR-RSKIKEQNNRDIAGIKDKLAKIR- 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1842 tleaETRVKQRLECEK--QQIQNDLNQWKTQYSR--KEEAIRKIESEREKSEREKNSLRSEIERLQAEIKriEERCRRkl 1917
Cdd:pfam12128  404 ----EARDRQLAVAEDdlQALESELREQLEAGKLefNEEEYRLKSRLGELKLRLNQATATPELLLQLENF--DERIER-- 475

                          330       340
                   ....*....|....*....|....*...
gi 1147813    1918 edsTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:pfam12128  476 ---AREEQEAANAEVERLQSELRQARKR 500
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1755-1941 1.16e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1755 QLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQctqvVQERESLLvkikvlEQDKARLQRLED 1834
Cdd:COG1579   11 DLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKE----IKRLELEI------EEVEARIKKYEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1835 ELNRAKSTLEAetrvkqrlecekQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCR 1914
Cdd:COG1579   81 QLGNVRNNKEY------------EALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELD 148

                        170       180
                 ....*....|....*....|....*..
gi 1147813  1915 RKLEDsTRETQSQLETERSRYQREIDK 1941
Cdd:COG1579  149 EELAE-LEAELEELEAEREELAAKIPP 174
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1234-1453 1.19e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.70  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1234 NLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRR--RAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARhKQ 1311
Cdd:COG3206  165 NLELRREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR-LA 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1312 SLEEAAKTIQDKNKEIERlKAEFQEEAKRRWEYENELSKVRNNYDEE---IISLKNQfeteINITKTtihQLTMQKEEDT 1388
Cdd:COG3206  244 ALRAQLGSGPDALPELLQ-SPVIQQLRAQLAELEAELAELSARYTPNhpdVIALRAQ----IAALRA---QLQQEAQRIL 315

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813  1389 SGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTEN---LRRVEEDIQQQKATGSEVSQRKQQLEVELRQ 1453
Cdd:COG3206  316 ASLEAELEALQAREASLQAQLAQLEARLAELPELeaeLRRLEREVEVARELYESLLQRLEEARLAEAL 383
growth_prot_Scy NF041483
polarized growth protein Scy;
1256-1938 1.32e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 47.90  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1256 LNDSILQATEQRRRAEENALQQKACGSEIMQK----KQHLEIELKQVMQQRSEdnaRHKQSLEEAAKTIQDKNKE----I 1327
Cdd:NF041483   78 LRNAQIQADQLRADAERELRDARAQTQRILQEhaehQARLQAELHTEAVQRRQ---QLDQELAERRQTVESHVNEnvawA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1328 ERLKAEFQEEAKR-----RWEYENELSKVRNnydeeiislknqfETEiNITKTTIHQLTMQKEEDtsgyRAQIDNLTREN 1402
Cdd:NF041483  155 EQLRARTESQARRlldesRAEAEQALAAARA-------------EAE-RLAEEARQRLGSEAESA----RAEAEAILRRA 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1403 RSLSEeikRLKNTL-TQTTENLRRVEediQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNK 1481
Cdd:NF041483  217 RKDAE---RLLNAAsTQAQEATDHAE---QLRSSTAAESDQARRQAAELSRAAEQRMQEAEEALREARAEAEKVVAEAKE 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1482 EIErlKQLIDKE-TNDRKC--LEDENARLqrVQYDLQKANSSATETinklkvqEQELTRLRIDYERVSQERTVKDQDITR 1558
Cdd:NF041483  291 AAA--KQLASAEsANEQRTrtAKEEIARL--VGEATKEAEALKAEA-------EQALADARAEAEKLVAEAAEKARTVAA 359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1559 fQNSLKELQLQKQKVEEELNRlkrtASEDS-CKRKKLEEELEGMRRSLKEQAIKITnlTQQLEQASIVKKRSEDDLRQQR 1637
Cdd:NF041483  360 -EDTAAQLAKAARTAEEVLTK----ASEDAkATTRAAAEEAERIRREAEAEADRLR--GEAADQAEQLKGAAKDDTKEYR 432

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1638 dvldghlREKQRTQEELRRLSSEVEALRRQLLQEQESVKqAHLRNEHFQKaIEDKSRSLneskieierlqsltenltkeh 1717
Cdd:NF041483  433 -------AKTVELQEEARRLRGEAEQLRAEAVAEGERIR-GEARREAVQQ-IEEAARTA--------------------- 482

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1718 lmlEEELRNLRLEYDDLRRGRSeADSDKNAT-ILELRSQLQISNNRTLElqglindlqrereNLRQEIEKFQKQALEASN 1796
Cdd:NF041483  483 ---EELLTKAKADADELRSTAT-AESERVRTeAIERATTLRRQAEETLE-------------RTRAEAERLRAEAEEQAE 545

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1797 RIQESKNQCTQVVQERESLLVKikvleqdkARLQRLEDELNRAKStlEAETRVkqrlecekqqiqndlnqwktqySRKEE 1876
Cdd:NF041483  546 EVRAAAERAARELREETERAIA--------ARQAEAAEELTRLHT--EAEERL----------------------TAAEE 593

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813   1877 AIrkieserekserekNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1938
Cdd:NF041483  594 AL--------------ADARAEAERIRREAAEETERLRTEAAERIRTLQAQAEQEAERLRTE 641
Filament pfam00038
Intermediate filament protein;
1702-1942 1.35e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 46.84  E-value: 1.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1702 EIERLQSLTENLTKEHLMLEEELRNLRLEYDDLR-------RGRSEADSDKNAtileLRSQLQisnnrTLELQGLinDLQ 1774
Cdd:pfam00038   55 EIEDLRRQLDTLTVERARLQLELDNLRLAAEDFRqkyedelNLRTSAENDLVG----LRKDLD-----EATLARV--DLE 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1775 RERENLRQEIEkFQKQALEASNRIQESKNQCTQVvqeresllvkikVLEQDKARLQRLEDELNRAKSTLEAETRvKQRLE 1854
Cdd:pfam00038  124 AKIESLKEELA-FLKKNHEEEVRELQAQVSDTQV------------NVEMDAARKLDLTSALAEIRAQYEEIAA-KNREE 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1855 CEKqqiqndlnQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCrRKLEDSTRETQSQLETERSR 1934
Cdd:pfam00038  190 AEE--------WYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQK-ASLERQLAETEERYELQLAD 260


                   ....*...
gi 1147813    1935 YQREIDKL 1942
Cdd:pfam00038  261 YQELISEL 268
End3 pfam12761
Actin cytoskeleton-regulatory complex protein END3; Endocytosis is accomplished through the ...
 1519-1655 1.42e-04

Actin cytoskeleton-regulatory complex protein END3; Endocytosis is accomplished through the sequential recruitment at endocytic sites of proteins that drive cargo sorting, membrane invagination and vesicle release. End3p is part of the coat module protein complex Pan1, along with Pan1p, Sla1p, and Sla2p. The proteins in this complex are regulated by phosphorylation events. End3p also regulates the cortical actin cytoskeleton. The subunits of the Pan1 complex are homologous to mammalian intersectin.


Pssm-ID: 432765 [Multi-domain]  Cd Length: 200  Bit Score: 45.37  E-value: 1.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1519 SSATETINKLKVQEQELTRLRID--YERVSQERTVKDQD--ITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKL 1594
Cdd:pfam12761   59 DSTTSTGRKAKFGDSYLSRLGVGgrSEKGTDFSATKGTDweEVRLKRELAELEEKLEKVEQAASKRRGGNRDESSKPALV 138

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813    1595 EEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSE-DDLRQQRDVLDGHLREKQRTQEELR 1655
Cdd:pfam12761  139 KREFEQLLDYKERQLRELEEGSGKSKPINLKSVREDiDTVEEQVDGLESHLSSRKQELQQLR 200
Filament pfam00038
Intermediate filament protein;
1171-1488 1.53e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 46.45  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1171 IERLRVLLQEegtrKREYENELAKVRNHYNEEMSNLRNKYETEINitkttikeismqkeddskNLRNQLDRLSRENRDLK 1250
Cdd:pfam00038   17 IDKVRFLEQQ----NKLLETKISELRQKKGAEPSRLYSLYEKEIE------------------DLRRQLDTLTVERARLQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1251 DEIvrlnDSILQATEQRRraeenalqqkacgseimqkkqhleielkqvmqQRSEDNARHKQSLEEaaktiqdknkEIERL 1330
Cdd:pfam00038   75 LEL----DNLRLAAEDFR--------------------------------QKYEDELNLRTSAEN----------DLVGL 108

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1331 KAEFQEEAKRRWEYENELSKVRnnydEEIISLKNQFETEINITKTTIHQLTMQKEEDTS----------GYRAQIDNLTR 1400
Cdd:pfam00038  109 RKDLDEATLARVDLEAKIESLK----EELAFLKKNHEEEVRELQAQVSDTQVNVEMDAArkldltsalaEIRAQYEEIAA 184

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1401 ENRSLSEE-----IKRLKNTLTQTTENLRRVEEDIqqqkatgSEVSQRKQQLEVELRQVTQMR---------TEEsvRYK 1466
Cdd:pfam00038  185 KNREEAEEwyqskLEELQQAAARNGDALRSAKEEI-------TELRRTIQSLEIELQSLKKQKaslerqlaeTEE--RYE 255

                          330       340
                   ....*....|....*....|..
gi 1147813    1467 QSLDDAAKTIQDKNKEIERLKQ 1488
Cdd:pfam00038  256 LQLADYQELISELEAELQETRQ 277
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
993-1340 1.54e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.45  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   993 LQEAADVHARYIELLTRsgdyyrfLSEMLKSLEDLKLKNTKIEVLEEELRLARDAnSENCNKNKFLDQNLQKYQAECSQF 1072
Cdd:COG4717   80 LKEAEEKEEEYAELQEE-------LEELEEELEELEAELEELREELEKLEKLLQL-LPLYQELEALEAELAELPERLEEL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1073 KAKLASLEELKRQAELDGKSAKQNLDKC-----------YGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQ 1141
Cdd:COG4717  152 EERLEELRELEEELEELEAELAELQEELeelleqlslatEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQ 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1142 LQKARQCEKEN-------------------------------------------LGWQKLESEKAIKEKEYEIERLRVLL 1178
Cdd:COG4717  232 LENELEAAALEerlkearlllliaaallallglggsllsliltiagvlflvlglLALLFLLLAREKASLGKEAEELQALP 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1179 QEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRL---------------- 1242
Cdd:COG4717  312 ALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALlaeagvedeeelraal 391

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1243 --SRENRDLKDEIVRLNDSILQATEqrrraEENALQQKACGSEIMQKKQHLEIELKQVMQQR---SEDNARHKQSLEEAA 1317
Cdd:COG4717  392 eqAEEYQELKEELEELEEQLEELLG-----ELEELLEALDEEELEEELEELEEELEELEEELeelREELAELEAELEQLE 466

                        410       420
                 ....*....|....*....|....*
gi 1147813  1318 K--TIQDKNKEIERLKAEFQEEAKR 1340
Cdd:COG4717  467 EdgELAELLQELEELKAELRELAEE 491
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1160-1534 1.69e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.32  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1160 SEKAIKEKEYEIERLRVLLQEEGTRKREYEN-----ELAKVRNHYNEEMSNLRNKYETEIniTKTTIKEISMQKEDDSKN 1234
Cdd:NF033838   56 QKEHAKEVESHLEKILSEIQKSLDKRKHTQNvalnkKLSDIKTEYLYELNVLKEKSEAEL--TSKTKKELDAAFEQFKKD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1235 LRNQLDRLSRENRDLKDEIVRLNDsilQATEQRRRAEENA---LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQ 1311
Cdd:NF033838  134 TLEPGKKVAEATKKVEEAEKKAKD---QKEEDRRNYPTNTyktLELEIAESDVEVKKAELELVKEEAKEPRDEEKIKQAK 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1312 SLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHqltmQKEEDTSGY 1391
Cdd:NF033838  211 AKVESKKAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPD----KKENDAKSS 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1392 RAQIDNLTRENRSLSEEIKrlkntltqTTENLRRVEEdiQQQKATGSEVSQRK-------QQLEVELrqvtqmrTEESVR 1464
Cdd:NF033838  287 DSSVGEETLPSPSLKPEKK--------VAEAEKKVEE--AKKKAKDQKEEDRRnyptntyKTLELEI-------AESDVK 349

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1465 YKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKcledENARLQRVQYDLQKANSSAtetinKLKVQEQE 1534
Cdd:NF033838  350 VKEAELELVKEEAKEPRNEEKIKQAKAKVESKKA----EATRLEKIKTDRKKAEEEA-----KRKAAEED 410
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1159-1452 1.86e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.06  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEIsmqkeddsKNLRNQ 1238
Cdd:COG1340    8 SSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKV--------KELKEE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1239 LDRLSRENRDLKDEIVRLNDsiLQATEQRRRAEENALQQKACGSEIMQKKQHLEIEL-KQVMQQRSEdnarhKQSLEEAA 1317
Cdd:COG1340   80 RDELNEKLNELREELDELRK--ELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEeKELVEKIKE-----LEKELEKA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN---NYDEEIISLKNQFETeinitkttihqltmqkeedtsgYRAQ 1394
Cdd:COG1340  153 KKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEeaqELHEEMIELYKEADE----------------------LRKE 210

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813  1395 IDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELR 1452
Cdd:COG1340  211 ADELHKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEELEEK 268
SPEC smart00150
Spectrin repeats;
285-373 1.89e-04

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 42.70  E-value: 1.89e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813      285 WINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQI 364
Cdd:smart00150   13 WLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLEELNERWEELKEL 92


                    ....*....
gi 1147813      365 TKCIDVHLK 373
Cdd:smart00150   93 AEERRQKLE 101
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1073-1204 2.08e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.77  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1073 KAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNdydQLQKARQCEKEn 1152
Cdd:COG2433  384 ELIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLER---ELSEARSEERR- 459

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 1147813  1153 lgwqKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMS 1204
Cdd:COG2433  460 ----EIRKDREISRLDREIERLERELEEERERIEELKRKLERLKELWKLEHS 507
PRK09039 PRK09039
peptidoglycan -binding protein;
1546-1697 2.16e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 46.11  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1546 SQERTVKDQDITRFQNSLKEL-------QLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQ 1618
Cdd:PRK09039   45 SREISGKDSALDRLNSQIAELadllsleRQGNQDLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAAEGRAGELAQE 124

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813   1619 LEQAsivKKRSEDDLRQqrdvldghlrekqrtqeeLRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697
Cdd:PRK09039  125 LDSE---KQVSARALAQ------------------VELLNQQIAALRRQLAALEAALDASEKRDRESQAKIADLGRRLN 182
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1723-1912 2.68e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1723 ELRNLRLEYDDLRRGRSEAdsdkNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESK 1802
Cdd:COG1579   11 DLQELDSELDRLEHRLKEL----PAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1803 NQctqvvQERESLLvkiKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKie 1882
Cdd:COG1579   87 NN-----KEYEALQ---KEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEA-- 156

                        170       180       190
                 ....*....|....*....|....*....|
gi 1147813  1883 sereksereknslrsEIERLQAEIKRIEER 1912
Cdd:COG1579  157 ---------------ELEELEAEREELAAK 171
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1004-1508 2.76e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 46.66  E-value: 2.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1004 IELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEElrlARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083
Cdd:pfam05557   30 IELEKKASALKRQLDRESDRNQELQKRIRLLEKREAE---AEEALREQAELNRLKKKYLEALNKKLNEKESQLADAREVI 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1084 RqaeldgkSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENlgwqklesEKA 1163
Cdd:pfam05557  107 S-------CLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLAEA--------EQR 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1164 IKEKEYEIER------LRVLLQEEGTRKREYENELAKVRNHyneemsnlrNKYETEINITKTTIKEismQKEDdsknLRN 1237
Cdd:pfam05557  172 IKELEFEIQSqeqdseIVKNSKSELARIPELEKELERLREH---------NKHLNENIENKLLLKE---EVED----LKR 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1238 QLDRlsrenrdlkdeivrlndsilqatEQRRRAEENALQqkacgseimQKKQHLEIELK--QVMQQRSEDNARHKQSLEE 1315
Cdd:pfam05557  236 KLER-----------------------EEKYREEAATLE---------LEKEKLEQELQswVKLAQDTGLNLRSPEDLSR 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1316 AAKTIQDKNK----EIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTihqLTMQKEEDtsGY 1391
Cdd:pfam05557  284 RIEQLQQREIvlkeENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRV---LLLTKERD--GY 358

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1392 RAQIDNLTREnrsLSEEikrlkNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQM-----RTEESVRYK 1466
Cdd:pfam05557  359 RAILESYDKE---LTMS-----NYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQaqtleRELQALRQQ 430

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1147813    1467 QSLDDAAKTiqdkNKEIERLKQLIDKETNDRKCLEDENARLQ 1508
Cdd:pfam05557  431 ESLADPSYS----KEEVDSLRRKLETLELERQRLREQKNELE 468
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1474-1945 2.76e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
Cdd:PRK01156  152 KKILDEILEINSLERNYDKLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAM 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1554 QDITRFQNSLKELQLQkqkvEEELNRLKRTASEdSCKRKKLEEELEGMRRSLKEQAIKITNltqqleqASIVKKRSEddl 1633
Cdd:PRK01156  232 DDYNNLKSALNELSSL----EDMKNRYESEIKT-AESDLSMELEKNNYYKELEERHMKIIN-------DPVYKNRNY--- 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1634 rqqrdvldghLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSR--SLNESKIEIERLQSLTE 1711
Cdd:PRK01156  297 ----------INDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYNDYIKKKSRydDLNNQILELEGYEMDYN 366

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1712 NLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQA 1791
Cdd:PRK01156  367 SYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNM 446

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1792 leasnRIQESKNQCTqvvqeresllVKIKVLEQDKARlqRLEDELNRAKSTLEAETRvkqRLECEKQQIQNDLNQWKtqy 1871
Cdd:PRK01156  447 -----EMLNGQSVCP----------VCGTTLGEEKSN--HIINHYNEKKSRLEEKIR---EIEIEVKDIDEKIVDLK--- 503

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1147813   1872 SRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:PRK01156  504 KRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVI 577
PRK12704 PRK12704
phosphodiesterase; Provisional
 1794-1939 2.77e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 46.31  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1794 ASNRIQESKNQCTQVVQERESllvKIKVLEQDKarLQRLEDELNRAKSTLEAETRVKQRlecEKQQIQNDLNQWKTQYSR 1873
Cdd:PRK12704   29 AEAKIKEAEEEAKRILEEAKK---EAEAIKKEA--LLEAKEEIHKLRNEFEKELRERRN---ELQKLEKRLLQKEENLDR 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813   1874 KEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDS---TRE---------TQSQLETERSRYQREI 1939
Cdd:PRK12704  101 KLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERIsglTAEeakeillekVEEEARHEAAVLIKEI 178
MutS2 COG1193
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];
1240-1374 2.83e-04

dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];


Pssm-ID: 440806 [Multi-domain]  Cd Length: 784  Bit Score: 46.67  E-value: 2.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1240 DRLSRENRDLKDEIVRLNDSILQATEQRRRAEEnaLQQkacgsEIMQKKQHLEIELKQVMQQRsedNARHKQSLEEAAKT 1319
Cdd:COG1193  507 ELLGEESIDVEKLIEELERERRELEEEREEAER--LRE-----ELEKLREELEEKLEELEEEK---EEILEKAREEAEEI 576

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1147813  1320 IQDKNKEIERLKAEFQEEAKRrweyENELSKVRnnydEEIISLKNQFETEINITK 1374
Cdd:COG1193  577 LREARKEAEELIRELREAQAE----EEELKEAR----KKLEELKQELEEKLEKPK 623
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1394-1741 3.35e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.66  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1394 QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVtqmrteesvryKQSLDDAA 1473
Cdd:COG4372   32 QLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAA-----------QAELAQAQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKvQEQELTRLRIDYERVSQERTVKD 1553
Cdd:COG4372  101 EELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELE-EQLESLQEELAALEQELQALSEA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633
Cdd:COG4372  180 EAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1634 RQQRDVLDGHLREKQRTQEELRRLSSEVEAlRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENL 1713
Cdd:COG4372  260 IEELELAILVEKDTEEEELEIAALELEALE-EAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAE 338

                        330       340
                 ....*....|....*....|....*...
gi 1147813  1714 TKEHLMLEEELRNLRLEYDDLRRGRSEA 1741
Cdd:COG4372  339 LADLLQLLLVGLLDNDVLELLSKGAEAG 366
growth_prot_Scy NF041483
polarized growth protein Scy;
1121-1915 4.10e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 46.36  E-value: 4.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1121 EKRRRKSVEDRFDQ----QKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLR--------------------- 1175
Cdd:NF041483  352 EKARTVAAEDTAAQlakaARTAEEVLTKASEDAKATTRAAAEEAERIRREAEAEADRLRgeaadqaeqlkgaakddtkey 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1176 ----VLLQEEGTRKReyeNELAKVRNHYNEEMSNLRNKYETE----INITKTTIKEISMQKEDDSKNLRNQLDRLSrenr 1247
Cdd:NF041483  432 raktVELQEEARRLR---GEAEQLRAEAVAEGERIRGEARREavqqIEEAARTAEELLTKAKADADELRSTATAES---- 504

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1248 dlkdEIVRlNDSILQATEQRRRAEENALQQKAcgseimQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKN--- 1324
Cdd:NF041483  505 ----ERVR-TEAIERATTLRRQAEETLERTRA------EAERLRAEAEEQAEEVRAAAERAARELREETERAIAARQaea 573

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1325 -KEIERLKAEFQE--------------EAKR-RWEYENELSKVRNNYDEEIISLKNQFETEINitkttihQLTMQKEEDT 1388
Cdd:NF041483  574 aEELTRLHTEAEErltaaeealadaraEAERiRREAAEETERLRTEAAERIRTLQAQAEQEAE-------RLRTEAAADA 646

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1389 SGYRAQIDNLTRENRS-LSEEIKRLKNTLTQTTENLR--------RVEEDIQQQKATGSEVSQRKQQLEVELrqVTQMRT 1459
Cdd:NF041483  647 SAARAEGENVAVRLRSeAAAEAERLKSEAQESADRVRaeaaaaaeRVGTEAAEALAAAQEEAARRRREAEET--LGSARA 724

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1460 E-----ESVRyKQS---LDDAAKTIQDKNKEIERLKqlidkETNDRKCLEDENARLQRVQydlqkansSATETINKLKVQ 1531
Cdd:NF041483  725 EadqerERAR-EQSeelLASARKRVEEAQAEAQRLV-----EEADRRATELVSAAEQTAQ--------QVRDSVAGLQEQ 790

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1532 -EQELTRLRIDYERVSQE-RTVKDQDITRFQNslkELQLQKQKVEEELNRLKRTASEDSCKRKKLEE--------ELEGM 1601
Cdd:NF041483  791 aEEEIAGLRSAAEHAAERtRTEAQEEADRVRS---DAYAERERASEDANRLRREAQEETEAAKALAErtvseaiaEAERL 867

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1602 RRSLKEQAIKI-TNLTQQLEQASIVKKRSEDDLRQ-----------QRDVLDGHLR-EKQRTQEELRrlsSEVEALRRQL 1668
Cdd:NF041483  868 RSDASEYAQRVrTEASDTLASAEQDAARTRADAREdanrirsdaaaQADRLIGEATsEAERLTAEAR---AEAERLRDEA 944

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1669 LQEQESVKQahlrnehfqKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNlrleydDLRRGRSEADsdknAT 1748
Cdd:NF041483  945 RAEAERVRA---------DAAAQAEQLIAEATGEAERLRAEAAETVGSAQQHAERIRT------EAERVKAEAA----AE 1005

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1749 ILELRSQLQISNNRTLelqglinDLQRERENLRQeiekfQKQALEASNRIQESKNQCTQVVQE--RESLLVKIKVLEQDK 1826
Cdd:NF041483 1006 AERLRTEAREEADRTL-------DEARKDANKRR-----SEAAEQADTLITEAAAEADQLTAKaqEEALRTTTEAEAQAD 1073

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1827 ARL--QRLEDELNRAKSTLEAETRVkqrlecekQQIQNDLNQWKTQYSRKEEAIRKieserekserEKNSLRseiERLQA 1904
Cdd:NF041483 1074 TMVgaARKEAERIVAEATVEGNSLV--------EKARTDADELLVGARRDATAIRE----------RAEELR---DRITG 1132

                         890
                  ....*....|.
gi 1147813   1905 EIKRIEERCRR 1915
Cdd:NF041483 1133 EIEELHERARR 1143
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1601-1958 4.26e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.12  E-value: 4.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1601 MRRSLKEQAIKITNL--TQQLEQASIVKKRSEDDLRQQRDVLDGHLR-EKQRTQEELRRLSSEV---EALRRQLLQEQES 1674
Cdd:TIGR00618  158 LKAKSKEKKELLMNLfpLDQYTQLALMEFAKKKSLHGKAELLTLRSQlLTLCTPCMPDTYHERKqvlEKELKHLREALQQ 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1675 VKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLtENLTKEHLMLEEELRNLR--LEYDDLRRGRSEADSDKNATILEL 1752
Cdd:TIGR00618  238 TQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEEL-RAQEAVLEETQERINRARkaAPLAAHIKAVTQIEQQAQRIHTEL 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1753 RSQLqisNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERE-SLLVKIKVLEQDKarlQR 1831
Cdd:TIGR00618  317 QSKM---RSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQhTLTQHIHTLQQQK---TT 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1832 LEDELNRAKSTLEAETRVKQRLECEKQQiQNDLNQWKTQYSRKEEAIRKIESEreksereknsLRSEIERlQAEIKRIEE 1911
Cdd:TIGR00618  391 LTQKLQSLCKELDILQREQATIDTRTSA-FRDLQGQLAHAKKQQELQQRYAEL----------CAAAITC-TAQCEKLEK 458

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 1147813    1912 RCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECE 1958
Cdd:TIGR00618  459 IHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCP 505
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1283-1451 4.62e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 4.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1283 EIMQKKQHLEIELKQVMQQRsednARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNydEEIisl 1362
Cdd:COG1579   21 RLEHRLKELPAELAELEDEL----AALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNN--KEY--- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1363 kNQFETEINITKTTIHQLtmqkEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKAtgsEVSQ 1442
Cdd:COG1579   92 -EALQKEIESLKRRISDL----EDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE---ELEA 163


                 ....*....
gi 1147813  1443 RKQQLEVEL 1451
Cdd:COG1579  164 EREELAAKI 172
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1643-1939 4.69e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 45.79  E-value: 4.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1643 HLREKQRTQEELRRLSSE-VEALRRQLLQEQESVKQAHLRN----EHFQKAIEDKSRSLNESKIE-IERLQSLTenLTKE 1716
Cdd:pfam05667  234 RLTPEEYRKRKRTKLLKRiAEQLRSAALAGTEATSGASRSAqdlaELLSSFSGSSTTDTGLTKGSrFTHTEKLQ--FTNE 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1717 HLMLEEELRNLRLEYDDLRRGRSEadsdknatilELRsqlqisnnrtlELQGLINDLQRERENLRQEIEKFQKQALEASN 1796
Cdd:pfam05667  312 APAATSSPPTKVETEEELQQQREE----------ELE-----------ELQEQLEDLESSIQELEKEIKKLESSIKQVEE 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1797 RIQESKNQCTQVVQERE------SLL-------VKIK-VLEQDKARLQRLEDELNRAKSTLEAETRvkqRLeceKQQIQN 1862
Cdd:pfam05667  371 ELEELKEQNEELEKQYKvkkktlDLLpdaeeniAKLQaLVDASAQRLVELAGQWEKHRVPLIEEYR---AL---KEAKSN 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1863 dlnqwktqysRKEEAIRKIesereksereknslrSEIERLQAEIKRIEERCRRKlEDSTRETQSQLE-----TERSRYQR 1937
Cdd:pfam05667  445 ----------KEDESQRKL---------------EEIKELREKIKEVAEEAKQK-EELYKQLVAEYErlpkdVSRSAYTR 498


                   ..
gi 1147813    1938 EI 1939
Cdd:pfam05667  499 RI 500
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 1011-1830 5.85e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 45.98  E-value: 5.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1011 GDYYRFLSEMLKSLEDLKLKNTKI-EVLEEELRLARDANSENCN-------KNKFLDQNLQKYQAECSQFKAKLASleel 1082
Cdd:PTZ00440 1133 EKIYKQMEKTLKELENMNLEDITLnEVNEIEIEYERILIDHIVEqinneakKSKTIMEEIESYKKDIDQVKKNMSK---- 1208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1083 KRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSveDRFDQQKNDYDqlqkarqcekENLGWQKLESEK 1162
Cdd:PTZ00440 1209 ERNDHLTTFEYNAYYDKATASYENIEELTTEAKGLKGEANRSTNV--DELKEIKLQVF----------SYLQQVIKENNK 1276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1163 aIKEKEYEIERLRVLLQEEGTRK--REYENELAKVRNHYN------EEMSNLRNKYETEINITKTTIKEISMQKEDDskn 1234
Cdd:PTZ00440 1277 -MENALHEIKNMYEFLISIDSEKilKEILNSTKKAEEFSNdakkelEKTDNLIKQVEAKIEQAKEHKNKIYGSLEDK--- 1352

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1235 lrnQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENalqqkaCGSEIMQ-KKQHLEIELKQVMQQrSEDNARHKQSL 1313
Cdd:PTZ00440 1353 ---QIDDEIKKIEQIKEEISNKRKEINKYLSNIKSNKEK------CDLHVRNaSRGKDKIDFLNKHEA-IEPSNSKEVNI 1422

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1314 EEAAKTIQD---KNKEIERLKAEFQEEAKRRWEYENELSKVRNNydEEIISLKNQFETEINiTKTTIhqltmqkeedtsg 1390
Cdd:PTZ00440 1423 IKITDNINKckqYSNEAMETENKADENNDSIIKYEKEITNILNN--SSILGKKTKLEKKKK-EATNI------------- 1486

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1391 yraqIDNLTRENRSLSEEIKRLKNTLTQTTE--NLRRVEEDIQQQKATGSEVSQRKQ--QLEVELRQVTQMRTEESVRYK 1466
Cdd:PTZ00440 1487 ----MDDINGEHSIIKTKLTKSSEKLNQLNEqpNIKREGDVLNNDKSTIAYETIQYNlgRVKHNLLNILNIKDEIETILN 1562

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1467 QSLDDAAKTIQ-DKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANssatETINKLKVQEQELTRLRIDYERV 1545
Cdd:PTZ00440 1563 KAQDLMRDISKiSKIVENKNLENLNDKEADYVKYLDNILKEKQLMEAEYKKLN----EIYSDVDNIEKELKKHKKNYEIG 1638

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1546 SQERTVK-DQDITRFQNSLKEL---------------QLQKQKVEEELNRLKRTASEdsckrkkLEEELEGMRRSLKEQA 1609
Cdd:PTZ00440 1639 LLEKVIEiNKNIKLYMDSTKESlnslvnnfsslfnnfYLNKYNINENLEKYKKKLNE-------IYNEFMESYNIIQEKM 1711

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1610 IKITNLTQQLEQASIVKK---RSEDDLRQQRDVLDGHLRE--KQRTQEELRRLSSEVEALRRQLLQEQESVKQAH---LR 1681
Cdd:PTZ00440 1712 KEVSNDDVDYNEAKTLREeaqKEEVNLNNKEEEAKKYLNDikKQESFRFILYMKEKLDELSKMCKQQYNIVDEGYnyiKK 1791

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1682 NEHFQKAIEDKSRSLNESKIEIERLQSLTEnltKEHLMLEEELRNLRLEYDDLRR----------GRSEADSDKN-ATIL 1750
Cdd:PTZ00440 1792 KIEYIKTLNDENNLSDSLNQAEDKNKEVAN---LTHYTNKNEAKNLLGHVVKSANfigikimtglQPTELTPDASlETAP 1868

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1751 ELRSQLQisNNRTLEL-QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARL 1829
Cdd:PTZ00440 1869 ELTFESE--NNSDLELdHLSSNKNELDVYKNIQDAYKSSLQILKYSDDIDKKQRDCNKLVEDGNEIYLKSTAINELKNMI 1946


                  .
gi 1147813   1830 Q 1830
Cdd:PTZ00440 1947 N 1947
Caldesmon pfam02029
Caldesmon;
1077-1347 5.89e-04

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 45.24  E-value: 5.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1077 ASLEELKRQAELDGKSAKQNLDKCygqiKELNEKITRLTYEIEdEKRRRKSVEDRFDQQKNDYDQLQKARQCEKEnlgwq 1156
Cdd:pfam02029   63 AFLDRTAKREERRQKRLQEALERQ----KEFDPTIADEKESVA-ERKENNEEEENSSWEKEEKRDSRLGRYKEEE----- 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1157 KLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINIT--------KTTIKEISMQK 1228
Cdd:pfam02029  133 TEIREKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYEskvfldqkRGHPEVKSQNG 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1229 EDDSKNLRNQLDRLSRENRDL---KDEIVRLNDSILQATEQRRRAEENALQQKacgSEIMQKKQHLEIELKQVMQQRSED 1305
Cdd:pfam02029  213 EEEVTKLKVTTKRRQGGLSQSqerEEEAEVFLEAEQKLEELRRRRQEKESEEF---EKLRQKQQEAELELEELKKKREER 289

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1147813    1306 narhKQSLEEAAKtiQDKNKEIERLKAEfqEEAKRRWEYENE 1347
Cdd:pfam02029  290 ----RKLLEEEEQ--RRKQEEAERKLRE--EEEKRRMKEEIE 323
mukB PRK04863
chromosome partition protein MukB;
1439-1845 6.27e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 45.72  E-value: 6.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1439 EVSQRKQQLEvelRQVTQMRTEEsVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR-KCLEDENARLQRVQYDLQKA 1517
Cdd:PRK04863  841 QLNRRRVELE---RALADHESQE-QQQRSQLEQAKEGLSALNRLLPRLNLLADETLADRvEEIREQLDEAEEAKRFVQQH 916

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1518 NSSATE---TINKLKVQEQELTRLRIDYERVSQERTVKDQDItrfqNSLKELQLQKQ--KVEEELNRLKRTASEDSCKRK 1592
Cdd:PRK04863  917 GNALAQlepIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQA----FALTEVVQRRAhfSYEDAAEMLAKNSDLNEKLRQ 992

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1593 KLEEeLEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLdghlreKQRTQEELRRLSSEVE---ALRRQLL 1669
Cdd:PRK04863  993 RLEQ-AEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQEL------KQELQDLGVPADSGAEeraRARRDEL 1065

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1670 QEQesvkqahLRNEHFQKAIEDKSRSLNESkiEIERLQSLTENLTKEHLMLEEELRN--------LRL--EYDDLRRGRS 1739
Cdd:PRK04863 1066 HAR-------LSANRSRRNQLEKQLTFCEA--EMDNLTKKLRKLERDYHEMREQVVNakagwcavLRLvkDNGVERRLHR 1136

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1740 EADSDKNATilELRSQLQISnnrtlelQGLINDLQRERENLRQeiekfqKQALEASNRIQESKNQC-TQVVQ---EResl 1815
Cdd:PRK04863 1137 RELAYLSAD--ELRSMSDKA-------LGALRLAVADNEHLRD------VLRLSEDPKRPERKVQFyIAVYQhlrER--- 1198

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1147813   1816 lvkikvLEQDKAR-------LQRLEDELNRAKSTLEA 1845
Cdd:PRK04863 1199 ------IRQDIIRtddpveaIEQMEIELSRLTEELTS 1229
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1013-1347 6.34e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 45.39  E-value: 6.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1013 YYRFLSEMLKSLE----------DLKLKNTKIEVLEEELRLARDANSENCNKNKF-LDQNLQKYQAECSQFKAKLASLEE 1081
Cdd:NF033838   67 LEKILSEIQKSLDkrkhtqnvalNKKLSDIKTEYLYELNVLKEKSEAELTSKTKKeLDAAFEQFKKDTLEPGKKVAEATK 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1082 LKRQAELDGKSAKQNLDKCYgqikelnEKITRLTYEIEDEKRRRKSVEDRFDQQKndyDQLQKARQCEKENLGWQKLESE 1161
Cdd:NF033838  147 KVEEAEKKAKDQKEEDRRNY-------PTNTYKTLELEIAESDVEVKKAELELVK---EEAKEPRDEEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKeismQKEDDSKNLRNQLDR 1241
Cdd:NF033838  217 KAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPD----KKENDAKSSDSSVGE 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1242 LSRENRDLKDEivrlnDSILQATEQRRRAEENALQQKA------------------CGSEIMQKKQHLEIELKQVMQQRS 1303
Cdd:NF033838  293 ETLPSPSLKPE-----KKVAEAEKKVEEAKKKAKDQKEedrrnyptntyktleleiAESDVKVKEAELELVKEEAKEPRN 367

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1147813   1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENE 1347
Cdd:NF033838  368 EEKIKQAKAKVESKKAEATRLEKIKTDRKKAEEEAKRKAAEEDK 411
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 1482-1797 6.76e-04

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 44.67  E-value: 6.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1482 EIERLKQLIDKETNDRKCLEDENA----RLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDY-ERVSQERTVK---- 1552
Cdd:pfam19220   49 RLLELEALLAQERAAYGKLRRELAgltrRLSAAEGELEELVARLAKLEAALREAEAAKEELRIELrDKTAQAEALErqla 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1553 --DQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLT---QQLEQASivkk 1627
Cdd:pfam19220  129 aeTEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELTrrlAELETQL---- 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1628 rseDDLRQQRDVLDGHL------REKQRTQEELRR---------LSSEVEALR------RQLLQEQesvkQAHLRNEhfQ 1686
Cdd:pfam19220  205 ---DATRARLRALEGQLaaeqaeRERAEAQLEEAVeahraerasLRMKLEALTaraaatEQLLAEA----RNQLRDR--D 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1687 KAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRnlrleydDLRRGRSEADSDKNATILELR---SQLQISNNRT 1763
Cdd:pfam19220  276 EAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQ-------EMQRARAELEERAEMLTKALAakdAALERAEERI 348

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1147813    1764 LELQGLINDLQRERENlrqeiekfQKQALEASNR 1797
Cdd:pfam19220  349 ASLSDRIAELTKRFEV--------ERAALEQANR 374
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1313-1416 8.65e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.85  E-value: 8.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1313 LEEAAKTIQDKNKEIERLKAEFQ------EEAKRRWE-YENELSKVRNNYDEEIISlknqfETEINITKTTIHQLtmqke 1385
Cdd:COG2433  408 LTEEEEEIRRLEEQVERLEAEVEeleaelEEKDERIErLERELSEARSEERREIRK-----DREISRLDREIERL----- 477

                         90       100       110
                 ....*....|....*....|....*....|.
gi 1147813  1386 edtsgyRAQIDNLTRENRSLSEEIKRLKNTL 1416
Cdd:COG2433  478 ------ERELEEERERIEELKRKLERLKELW 502
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 1250-1490 8.85e-04

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 44.84  E-value: 8.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1250 KDEIVRLNDSI--LQATEQRRRAEENALQQK---------ACGSEIMQKKQH---LEIELKQVMQQRSEDnarhKQSLEE 1315
Cdd:pfam09726  394 PDALVRLEQDIkkLKAELQASRQTEQELRSQissltslerSLKSELGQLRQEndlLQTKLHNAVSAKQKD----KQTVQQ 469

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1316 AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVR----NNYDEEIISLKN---QFETEInitKTTIHQLTMQKEedt 1388
Cdd:pfam09726  470 LEKRLKAEQEARASAEKQLAEEKKRKKEEEATAARAValaaASRGECTESLKQrkrELESEI---KKLTHDIKLKEE--- 543

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1389 sgyraQIDNLTRENRSLSEEIKRLKNTLTQTTEnLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVtqmrteesvryKQS 1468
Cdd:pfam09726  544 -----QIRELEIKVQELRKYKESEKDTEVLMSA-LSAMQDKNQHLENSLSAETRIKLDLFSALGDA-----------KRQ 606

                          250       260
                   ....*....|....*....|..
gi 1147813    1469 LDDAAKTIQDKNKEIERLKQLI 1490
Cdd:pfam09726  607 LEIAQGQIYQKDQEIKDLKQKI 628
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1594-1854 8.91e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 8.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1594 LEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673
Cdd:COG4372   29 LSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1674 SVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELR 1753
Cdd:COG4372  109 EAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDEL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1754 SQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLE 1833
Cdd:COG4372  189 LKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAIL 268

                        250       260
                 ....*....|....*....|.
gi 1147813  1834 DELNRAKSTLEAETRVKQRLE 1854
Cdd:COG4372  269 VEKDTEEEELEIAALELEALE 289
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1550-1938 9.39e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.78  E-value: 9.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1550 TVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEG---MRRSLKEQAIKITNLTQQLEQasiVK 1626
Cdd:pfam01576    1 TRQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAeteLCAEAEEMRARLAARKQELEE---IL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1627 KRSEDDLRQQRDVLDGHLREKQRTQEELRRLSS---EVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN-ESKIE 1702
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKKKMQQHIQDLEEqldEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSkERKLL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1703 IERLQSLTENLTKEHLM-----------------LEEELR---NLRLEYDDLRRgRSEADS--------DKNATILELRS 1754
Cdd:pfam01576  158 EERISEFTSNLAEEEEKakslsklknkheamisdLEERLKkeeKGRQELEKAKR-KLEGEStdlqeqiaELQAQIAELRA 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1755 QLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE----------- 1823
Cdd:pfam01576  237 QLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKteledtldtta 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1824 -QDKARLQRlEDELNRAKSTLEAETRVK----QRLECEKQQIQNDLNQWKTQYSRKEEAIRKieserekserEKNSLRSE 1898
Cdd:pfam01576  317 aQQELRSKR-EQEVTELKKALEEETRSHeaqlQEMRQKHTQALEELTEQLEQAKRNKANLEK----------AKQALESE 385

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1147813    1899 IERLQAEIKRIE------ERCRRKLEDSTRETQSQL-ETERSRYQRE 1938
Cdd:pfam01576  386 NAELQAELRTLQqakqdsEHKRKKLEGQLQELQARLsESERQRAELA 432
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 1590-1945 1.10e-03

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 44.63  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1590 KRKKLEEELEGMRrslkeqaikitnltqqlEQASIVKKRSEDDLRQQRDVLDghlrEKQRTQEELRRLSSEVEALRRQLL 1669
Cdd:pfam05701   36 RRKLVELELEKVQ-----------------EEIPEYKKQSEAAEAAKAQVLE----ELESTKRLIEELKLNLERAQTEEA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1670 QEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI--ERLQSLTENLTkehlMLEEELRNLRLEYDDLRRGRSEADSDKNA 1747
Cdd:pfam05701   95 QAKQDSELAKLRVEEMEQGIADEASVAAKAQLEVakARHAAAVAELK----SVKEELESLRKEYASLVSERDIAIKRAEE 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1748 TILELRSQLQISNNRTLELQGLINDLQ-------------------RERENLRQEIEkfQKQALEASNRIQEsknqctQV 1808
Cdd:pfam05701  171 AVSASKEIEKTVEELTIELIATKESLEsahaahleaeehrigaalaREQDKLNWEKE--LKQAEEELQRLNQ------QL 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1809 VQEREsllVKIKvLEQDKARLQRLEDELN-RAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREK 1887
Cdd:pfam05701  243 LSAKD---LKSK-LETASALLLDLKAELAaYMESKLKEEADGEGNEKKTSTSIQAALASAKKELEEVKANIEKAKDEVNC 318

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813    1888 SEREKNSLRSEIERLQAEIKRIeercrRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:pfam05701  319 LRVAAASLRSELEKEKAELASL-----RQREGMASIAVSSLEAELNRTKSEIALVQAK 371
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1770-1934 1.36e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.74  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1770 INDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQEresllvkikvLEQDKARLQRLEDELNRAKSTLEAETRV 1849
Cdd:COG4372   40 LDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEE----------LEELNEQLQAAQAELAQAQEELESLQEE 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1850 KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLE 1929
Cdd:COG4372  110 AEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELL 189


                 ....*
gi 1147813  1930 TERSR 1934
Cdd:COG4372  190 KEANR 194
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1233-1544 1.74e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.06  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1233 KNLRNQLDRLSRENRDLKDEIVrlndsilQATEQRRRAEENALQQKAcgseiMQKKQhLEIELKQVMQQRSEDNARHKQS 1312
Cdd:pfam12128  649 KNARLDLRRLFDEKQSEKDKKN-------KALAERKDSANERLNSLE-----AQLKQ-LDKKHQAWLEEQKEQKREARTE 715

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1313 LEEAAK-TIQDKNKEIERLKAEF---QEEAKRRW-----EYENELSKVrnNYDEEIISlknQFETEINITKTTIHQLTMQ 1383
Cdd:pfam12128  716 KQAYWQvVEGALDAQLALLKAAIaarRSGAKAELkaletWYKRDLASL--GVDPDVIA---KLKREIRTLERKIERIAVR 790

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1384 KEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA---TGSEVSqRKQQLEV--ELRQV-TQM 1457
Cdd:pfam12128  791 RQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLIADTKLRRAkleMERKAS-EKQQVRLseNLRGLrCEM 869

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1458 RTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDrkcLEDENARLQRVQYDlqKANSSATETINKLKVQEQELTR 1537
Cdd:pfam12128  870 SKLATLKEDANSEQAQGSIGERLAQLEDLKLKRDYLSES---VKKYVEHFKNVIAD--HSGSGLAETWESLREEDHYQND 944


                   ....*....
gi 1147813    1538 --LRIDYER 1544
Cdd:pfam12128  945 kgIRLLDYR 953
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1025-1338 1.88e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.35  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1025 EDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQI 1104
Cdd:COG4372   52 EELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQR 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1105 KELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLR---VLLQEE 1181
Cdd:COG4372  132 KQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELaeaEKLIES 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1182 GTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSIL 1261
Cdd:COG4372  212 LPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEA 291

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813  1262 QATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEA 1338
Cdd:COG4372  292 ALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVA 368
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1766-1945 2.53e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.57  E-value: 2.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1766 LQGLINDLQRERE-NLRQEIEKFQKQALEasnRIQESKNQCTQVVQEREsllvkiKVLEQDKARlqrlEDELNRAKSTLE 1844
Cdd:pfam17380  271 LNQLLHIVQHQKAvSERQQQEKFEKMEQE---RLRQEKEEKAREVERRR------KLEEAEKAR----QAEMDRQAAIYA 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1845 AETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIesereksereknSLRSEIERLQAEIKRIEERCRRKLEDSTRet 1924
Cdd:pfam17380  338 EQERMAMERERELERIRQEERKRELERIRQEEIAMEI------------SRMRELERLQMERQQKNERVRQELEAARK-- 403

                          170       180
                   ....*....|....*....|....*
gi 1147813    1925 QSQLETERSR----YQREIDKLRQR 1945
Cdd:pfam17380  404 VKILEEERQRkiqqQKVEMEQIRAE 428
46 PHA02562
endonuclease subunit; Provisional
 1193-1430 2.54e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.08  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1193 AKVR--NHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRA 1270
Cdd:PHA02562  174 DKIRelNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDP 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1271 EE--NALQQKAC--GSEIMQ-KKQHLEIELKQV----MQQRSEDNARhkqsLEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
Cdd:PHA02562  254 SAalNKLNTAAAkiKSKIEQfQKVIKMYEKGGVcptcTQQISEGPDR----ITKIKDKLKELQHSLEKLDTAIDELEEIM 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1342 WEYeNELSKvrnnydeEIISLKNQFETEinitkttiHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTE 1421
Cdd:PHA02562  330 DEF-NEQSK-------KLLELKNKISTN--------KQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVK 393


                  ....*....
gi 1147813   1422 NLRRVEEDI 1430
Cdd:PHA02562  394 TKSELVKEK 402
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1629-1905 2.72e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1629 SEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAhlrnehfQKAIEDKSRSLNESKIEIERLQS 1708
Cdd:COG3883   14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEAL-------QAEIDKLQAEIAEAEAEIEERRE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1709 LtenltkehlmLEEELRNLRleyddlrrgRSEADSDKNATILELRSqlqisnnrtleLQGLINdlqreRENLRQEIEKFQ 1788
Cdd:COG3883   87 E----------LGERARALY---------RSGGSVSYLDVLLGSES-----------FSDFLD-----RLSALSKIADAD 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1789 KQALEasnriqesknqctQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE----TRVKQRLECEKQQIQNDL 1864
Cdd:COG3883  132 ADLLE-------------ELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQqaeqEALLAQLSAEEAAAEAQL 198

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 1147813  1865 NQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAE 1905
Cdd:COG3883  199 AELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 1221-1587 2.72e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 43.30  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1221 IKEISMQKEDDSKNlrnqldrlsrENRDLKDEIVRLNDSILQATEQRRRAEENALqqkacgSEIMQK-KQHLEIELKQVM 1299
Cdd:PLN03229  416 ERKVNMKKREAVKT----------PVRELEGEVEKLKEQILKAKESSSKPSELAL------NEMIEKlKKEIDLEYTEAV 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1300 QQRSEDNARHKQSLEEAAKTIQDK------NKEIERLKAEFQEEAKRRWEYEnelskvrnnydeeiiSLKNQFE--TEIN 1371
Cdd:PLN03229  480 IAMGLQERLENLREEFSKANSQDQlmhpvlMEKIEKLKDEFNKRLSRAPNYL---------------SLKYKLDmlNEFS 544

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1372 ITKTtihqlTMQKEEDTSGYRAQIdnltreNRSLSEEIKRlkntlTQTTENLRRVEEDIQQQKA---------TGSEVSQ 1442
Cdd:PLN03229  545 RAKA-----LSEKKSKAEKLKAEI------NKKFKEVMDR-----PEIKEKMEALKAEVASSGAssgdeldddLKEKVEK 608

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1443 RKQQLEVELRQVTQ-MRTEESVRYKQSLDDAAKTIQDKNKE-IERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSS 1520
Cdd:PLN03229  609 MKKEIELELAGVLKsMGLEVIGVTKKNKDTAEQTPPPNLQEkIESLNEEINKKIERVIRSSDLKSKIELLKLEVAKASKT 688

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1147813   1521 ----ATETINKLKVQEQELTRLRIDYERVSQertvkdqditRFQNSLKELQLQKQKVEEELNRLKRTASED 1587
Cdd:PLN03229  689 pdvtEKEKIEALEQQIKQKIAEALNSSELKE----------KFEELEAELAAARETAAESNGSLKNDDDKE 749
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1710-1945 2.85e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 42.59  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1710 TENLTKEHLMLEEELRNLRLEYDDLRRGRSEAdsdkNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQK 1789
Cdd:COG1340    3 TDELSSSLEELEEKIEELREEIEELKEKRDEL----NEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1790 QALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLecekQQIQNDLNQWKT 1869
Cdd:COG1340   79 ERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEEKELVEKI----KELEKELEKAKK 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1147813  1870 QYSRKEEaIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER---CRRKLeDSTRETQSQLETERSRYQREIDKLRQR 1945
Cdd:COG1340  155 ALEKNEK-LKELRAELKELRKEAEEIHKKIKELAEEAQELHEEmieLYKEA-DELRKEADELHKEIVEAQEKADELHEE 231
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1645-1836 2.94e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 43.31  E-value: 2.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1645 REKQRTQEELRRLSSEVEALRRQllqeqesvkqahlrNEHFQKAIEDKSRslneskiEIERLqsltenltkehlmlEEEL 1724
Cdd:COG2433  406 RELTEEEEEIRRLEEQVERLEAE--------------VEELEAELEEKDE-------RIERL--------------EREL 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1725 RNLRleyddlRRGRSEADSDKNATILElrsqlqisnNRTLELQGLINDLQRERENLRQEIEKFQK-QALEASNRiqeskn 1803
Cdd:COG2433  451 SEAR------SEERREIRKDREISRLD---------REIERLERELEEERERIEELKRKLERLKElWKLEHSGE------ 509

                        170       180       190
                 ....*....|....*....|....*....|....
gi 1147813  1804 qctqvvqereslLVKIKVLEQ-DKARLQRLEDEL 1836
Cdd:COG2433  510 ------------LVPVKVVEKfTKEAIRRLEEEY 531
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1372-1541 3.10e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 43.09  E-value: 3.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1372 ITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRV------------------------E 1427
Cdd:pfam05667  321 TKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELkeqneelekqykvkkktldllpdaE 400

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1428 EDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARL 1507
Cdd:pfam05667  401 ENIAKLQALVDASAQRLVELAGQWEKHRVPLIEEYRALKEAKSNKEDESQRKLEEIKELREKIKEVAEEAKQKEELYKQL 480

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1147813    1508 QRvqyDLQKAN-----SSAT----ETINKLKVQEQELTRLRID 1541
Cdd:pfam05667  481 VA---EYERLPkdvsrSAYTrrilEIVKNIKKQKEEITKILSD 520
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1017-1431 3.18e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 42.90  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1017 LSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC-NKNKFLDQNLQKYQAECSQFkaklaslEELKrqaeldgksAKQ 1095
Cdd:PRK04778  128 LQELLESEEKNREEVEQLKDLYRELRKSLLANRFSFgPALDELEKQLENLEEEFSQF-------VELT---------ESG 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1096 NLDKCYGQIKELNEKITRLTYEIEDekrrrksVEDRFDQQKNDY-DQLQK----ARQCEKENLGWQKLESEKAIKEKEYE 1170
Cdd:PRK04778  192 DYVEAREILDQLEEELAALEQIMEE-------IPELLKELQTELpDQLQElkagYRELVEEGYHLDHLDIEKEIQDLKEQ 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1171 IERLRVLLQEEGTRKREYENElakvrnHYNEEMSNLRNKYETEINITKTTIKEIsmqkeddsKNLRNQLDRLSRENRDLK 1250
Cdd:PRK04778  265 IDENLALLEELDLDEAEEKNE------EIQERIDQLYDILEREVKARKYVEKNS--------DTLPDFLEHAKEQNKELK 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1251 DEIVRLNDS-ILQATE-QRRRAEENALQqkacgseiMQKKQHLEIelkqvmQQRSEDNARHKQSLEEAAKTIQDKNKEIE 1328
Cdd:PRK04778  331 EEIDRVKQSyTLNESElESVRQLEKQLE--------SLEKQYDEI------TERIAEQEIAYSELQEELEEILKQLEEIE 396

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1329 RLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLK------------NQFETEINITKTTIHQLTMQKEEdtsgYRAQID 1396
Cdd:PRK04778  397 KEQEKLSEMLQGLRKDELEAREKLERYRNKLHEIKryleksnlpglpEDYLEMFFEVSDEIEALAEELEE----KPINME 472

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1147813   1397 NLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQ 1431
Cdd:PRK04778  473 AVNRLLEEATEDVETLEEETEELVENATLTEQLIQ 507
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1237-1521 3.25e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 42.21  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1237 NQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDN---ARHKQSL 1313
Cdd:COG1340    1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNekvKELKEER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1314 EEAAKTIQDKNKEIERLKAEFQEEAKRRWEYEnELSKvrnnydeEIISLKNQFETEInitkttihqLTMQKEEDTSGYRA 1393
Cdd:COG1340   81 DELNEKLNELREELDELRKELAELNKAGGSID-KLRK-------EIERLEWRQQTEV---------LSPEEEKELVEKIK 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1394 QIDNLTRENRSLSEEIKRLKNTLTQTTEnLRRVEEDIQQQKATGSEVSQRKQQLEVELRQvtqmrteESVRYKQSLDDAA 1473
Cdd:COG1340  144 ELEKELEKAKKALEKNEKLKELRAELKE-LRKEAEEIHKKIKELAEEAQELHEEMIELYK-------EADELRKEADELH 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 1147813  1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSA 1521
Cdd:COG1340  216 KEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKE 263
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1534-1937 3.60e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.11  E-value: 3.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1534 ELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKR---KKLEEELEGMRRSLKEQAI 1610
Cdd:TIGR00606  180 SATRYIKALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSReivKSYENELDPLKNRLKEIEH 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1611 KITNLTQQLEQASIVKKRseddlRQQRDVLDGHLREK-----QRTQEELRRL----SSEVEALRRQLLQEQESVKQahlr 1681
Cdd:TIGR00606  260 NLSKIMKLDNEIKALKSR-----KKQMEKDNSELELKmekvfQGTDEQLNDLyhnhQRTVREKERELVDCQRELEK---- 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1682 nehfqkaIEDKSRSLNESKIEIERLQ---SLTENLTKEHLMLEEELR---NLRLEYDDLRRG-------------RSEAD 1742
Cdd:TIGR00606  331 -------LNKERRLLNQEKTELLVEQgrlQLQADRHQEHIRARDSLIqslATRLELDGFERGpfserqiknfhtlVIERQ 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1743 SDKNATILELRSQLQiSNNRT---------LELQGLINDLQRERENLRQEIE-----KFQKQALEAS-NRIQESKNQCTQ 1807
Cdd:TIGR00606  404 EDEAKTAAQLCADLQ-SKERLkqeqadeirDEKKGLGRTIELKKEILEKKQEelkfvIKELQQLEGSsDRILELDQELRK 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1808 VVQE---------RESLLVKIKVLEQDKARLQRLE-------DELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ----- 1866
Cdd:TIGR00606  483 AERElskaeknslTETLKKEVKSLQNEKADLDRKLrkldqemEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRhsdel 562

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1867 --------WKTQYSR-----------KEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER----CRRKLEDSTRE 1923
Cdd:TIGR00606  563 tsllgyfpNKKQLEDwlhskskeinqTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKlfdvCGSQDEESDLE 642

                          490
                   ....*....|....
gi 1147813    1924 TQSQlETERSRYQR 1937
Cdd:TIGR00606  643 RLKE-EIEKSSKQR 655
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1553-1854 3.65e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1553 DQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD 1632
Cdd:COG4372    2 DRLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1633 LRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTEN 1712
Cdd:COG4372   82 LEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLES 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1713 ltkehlmLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQAL 1792
Cdd:COG4372  162 -------LQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLA 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813  1793 EASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLE 1854
Cdd:COG4372  235 LSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELK 296
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 1310-1488 4.05e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 42.05  E-value: 4.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1310 KQSLEE----AAKTIQDKNKEIERLKAEFQEEAkrrweyeNELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKE 1385
Cdd:pfam09787    6 KQELADykqkAARILQSKEKLIASLKEGSGVEG-------LDSSTALTLELEELRQERDLLREEIQKLRGQIQQLRTELQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1386 EDTSGYRAQIDNLTRENRSLSEEI-------KRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRK-------------- 1444
Cdd:pfam09787   79 ELEAQQQEEAESSREQLQELEEQLatersarREAEAELERLQEELRYLEEELRRSKATLQSRIKDReaeieklrnqltsk 158

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1147813    1445 -------QQLEVELRQVTqmrteESVRYKQSLDDAAKTiqDKNK---EIERLKQ 1488
Cdd:pfam09787  159 sqssssqSELENRLHQLT-----ETLIQKQTMLEALST--EKNSlvlQLERMEQ 205
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1398-1635 4.29e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.11  E-value: 4.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1398 LTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTqmRTEESVRYKQSLDDAAKTIQ 1477
Cdd:pfam15905   78 LEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLELT--RVNELLKAKFSEDGTQKKMS 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1478 DKNKEIERLKQLID-KETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERT----VK 1552
Cdd:pfam15905  156 SLSMELMKLRNKLEaKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITelscVS 235

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1553 DQ------DITRFQNSLK----ELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQA 1622
Cdd:pfam15905  236 EQvekyklDIAQLEELLKekndEIESLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLNAELEELKEK 315

                          250
                   ....*....|...
gi 1147813    1623 SIVKKRSEDDLRQ 1635
Cdd:pfam15905  316 LTLEEQEHQKLQQ 328
ATG17_like pfam04108
Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ...
 1471-1787 4.30e-03

Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ATG17 and ATG11, conserved across eukaryotes. ATG17 forms a complex with ATG29 and ATG31, critical for both PAS (preautophagosomal structure) formation and autophagy. Together with ATG13, it is required for ATG1 kinase activation. ATG11 is a scaffold protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway during starvation and to recruit ATG proteins to the pre-autophagosome. It is also required for ATG1 kinase activation. In many eukaryotes, ATG11 (the orthologue in mammals is RB1-inducible coiled-coil protein 1 (RB1CC1) and in S. pombe is Taz1-interacting factor 1 (taf1)) is essential for bulk autophagy, except in S.cerevisiae. ATG17 and ATG11 are large similar proteins, both predicted to be almost entirely helical, containing conserved coiled-coil regions and lack obvious functional motifs.


Pssm-ID: 427715 [Multi-domain]  Cd Length: 360  Bit Score: 41.99  E-value: 4.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1471 DAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQE--------LTRLR--- 1539
Cdd:pfam04108   11 WANELLTDARSLLEELVVLLAKIAFLRRGLSVQLANLEKVREGLEKVLNELKKDFKQLLKDLDAalerleetLDKLRntp 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1540 ------------------IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLK---RTASEDSCKRKKLEEEL 1598
Cdd:pfam04108   91 vepalppgeekqktlldfIDEDSVEILRDALKELIDELQAAQESLDSDLKRFDDDLRDLQkelESLSSPSESISLIPTLL 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1599 EGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQA 1678
Cdd:pfam04108  171 KELESLEEEMASLLESLTNHYDQCVTAVKLTEGGRAEMLEVLENDARELDDVVPELQDRLDEMENNYERLQKLLEQKNSL 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1679 HLRNEHFQKAIEDKSRSLNESkieIERLQSLTENLTKEHLMLEEELRnlrlEYDDLRRGRSEADSDKNATILELRSQ--- 1755
Cdd:pfam04108  251 IDELLSALQLIAEIQSRLPEY---LAALKEFEERWEEEKETIEDYLS----ELEDLREFYEGFPSAYGSLLLEVERRrew 323

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1147813    1756 ----LQISNNRTLELQGLINDLQRERENLRQEIEKF 1787
Cdd:pfam04108  324 aekmKKILRKLAEELDRLQEEERKRREKFLKEVGDF 359
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
 1491-1623 4.69e-03

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 42.74  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1491 DKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQ----EQELTRLRIDYERvSQERTVKDQDITRFQN-SLKE 1565
Cdd:pfam05911  677 DLKTEENKRLKEEFEQLKSEKENLEVELASCTENLESTKSQlqesEQLIAELRSELAS-LKESNSLAETQLKCMAeSYED 755

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1147813    1566 LQLQKQKVEEELNRLKRtasedscKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQAS 1623
Cdd:pfam05911  756 LETRLTELEAELNELRQ-------KFEALEVELEEEKNCHEELEAKCLELQEQLERNE 806
PLEC smart00250
Plectin repeat;
2762-2799 4.77e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.08  E-value: 4.77e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1147813     2762 QRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG 2799
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 1673-1877 4.91e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 41.13  E-value: 4.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1673 ESVKQAHLRNEHFQKAIEDKSRSLN------ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDlrrgrSEADSDKN 1746
Cdd:pfam12795    3 DELEKAKLDEAAKKKLLQDLQQALSlldkidASKQRAAAYQKALDDAPAELRELRQELAALQAKAEA-----APKEILAS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1747 ATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQV----VQERESLLVKIKV- 1821
Cdd:pfam12795   78 LSLEELEQRLLQTSAQLQELQNQLAQLNSQLIELQTRPERAQQQLSEARQRLQQIRNRLNGPappgEPLSEAQRWALQAe 157

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1147813    1822 LEQDKARLQRLEDEL----NR---AKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEA 1877
Cdd:pfam12795  158 LAALKAQIDMLEQELlsnnNRqdlLKARRDLLTLRIQRLEQQLQALQELLNEKRLQEAEQAVA 220
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1529-1657 5.55e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.15  E-value: 5.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1529 KVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEdsckrkkLEEELEGMRRSLKEQ 1608
Cdd:COG2433  388 KELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIER-------LERELSEARSEERRE 460

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 1147813  1609 AikitnltqqLEQASIVKKRSE-DDLRQQRDVLDGHLREKQRTQEELRRL 1657
Cdd:COG2433  461 I---------RKDREISRLDREiERLERELEEERERIEELKRKLERLKEL 501
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 870-1837 5.78e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 42.51  E-value: 5.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    870 IDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDRKRRQDSLESMKFGDSNTVMRfLNEQKNLHSEISGKRDKSEEVQK 949
Cdd:PTZ00440  444 IKKKYDEKINELKKSINQLKTLISIMKSFYDLIISEKDSMDSKEKKESSDSNYQEK-VDELLQIINSIKEKNNIVNNNFK 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    950 iaelcanSIKDYELQLasytSGLETLLNIPIKrtMIQSpsgvilqeaadvharyielltrsgdyyrFLSEMLKSLEDLKL 1029
Cdd:PTZ00440  523 -------NIEDYYITI----EGLKNEIEGLIE--LIKY----------------------------YLQSIETLIKDEKL 561

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1030 KNTKIEVLEEELRLARDaNSENCNKNKFLDQNLQKYQAECSQ-FKAKLASLEELKRQAELDGKSAKQNLDKCY-GQIKEL 1107
Cdd:PTZ00440  562 KRSMKNDIKNKIKYIEE-NVDHIKDIISLNDEIDNIIQQIEElINEALFNKEKFINEKNDLQEKVKYILNKFYkGDLQEL 640

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1108 NEKITRLTYEIEDEKRRRKSvedrfdqqKNDYDQLQKARQCEKENLGWQKLESEKAIkekeyeIERLRVLLQEEGTRKre 1187
Cdd:PTZ00440  641 LDELSHFLDDHKYLYHEAKS--------KEDLQTLLNTSKNEYEKLEFMKSDNIDNI------IKNLKKELQNLLSLK-- 704

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1188 yENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEdDSKNLRNQLdrlsrenrdlkdeIVRLNDSILQATEQr 1267
Cdd:PTZ00440  705 -ENIIKKQLNNIEQDISNSLNQYTIKYNDLKSSIEEYKEEEE-KLEVYKHQI-------------INRKNEFILHLYEN- 768

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1268 rraEENALQQKACGSEIMQKKQHLEIELKQVmqqrSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEakrrweyENE 1347
Cdd:PTZ00440  769 ---DKDLPDGKNTYEEFLQYKDTILNKENKI----SNDINILKENKKNNQDLLNSYNILIQKLEAHTEKN-------DEE 834

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1348 LSKVRNNYDEEIISLK-----NQFETEINITKTTIHQL-TMQKEEDTSGYRAQIDNLTRENRSLSEEIKR----LKNTLT 1417
Cdd:PTZ00440  835 LKQLLQKFPTEDENLNlkeleKEFNENNQIVDNIIKDIeNMNKNINIIKTLNIAINRSNSNKQLVEHLLNnkidLKNKLE 914

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1418 Q-----TTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRY----KQSLDDAAKTIQDK----NKEIE 1484
Cdd:PTZ00440  915 QhmkiiNTDNIIQKNEKLNLLNNLNKEKEKIEKQLSDTKINNLKMQIEKTLEYydksKENINGNDGTHLEKldkeKDEWE 994

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1485 RLKQLIDKETNDRKCLEDENARLQRVQYD------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
Cdd:PTZ00440  995 HFKSEIDKLNVNYNILNKKIDDLIKKQHDdiieliDKLIKEKGKEIEEKVDQYISLLEKMKTKLSSFHFNIDIKKYKNPK 1074

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1559 FQNSLKELQLQKQKVE-------EELNRLKRTASED---------------SCKRKKLEEELEGMRRSLKE--QAIKITN 1614
Cdd:PTZ00440 1075 IKEEIKLLEEKVEALLkkidenkNKLIEIKNKSHEHvvnadkeknkqtehyNKKKKSLEKIYKQMEKTLKEleNMNLEDI 1154

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1615 LTQQLEQASIVKKRSE-DDLRQQrdvLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI---- 1689
Cdd:PTZ00440 1155 TLNEVNEIEIEYERILiDHIVEQ---INNEAKKSKTIMEEIESYKKDIDQVKKNMSKERNDHLTTFEYNAYYDKATasye 1231

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1690 -------------EDKSRSLNESKIEIERLQSLT--ENLTKEHLMLEEELRNLRLEYDDLrrgrseaDSDKNATILElrs 1754
Cdd:PTZ00440 1232 nieeltteakglkGEANRSTNVDELKEIKLQVFSylQQVIKENNKMENALHEIKNMYEFL-------ISIDSEKILK--- 1301

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1755 qlQISNNrTLELQGLINDLQRERE---NLRQEIEKFQKQALEASNRIQESknqctqvvQERESLLVKIKVLEQDKARLQR 1831
Cdd:PTZ00440 1302 --EILNS-TKKAEEFSNDAKKELEktdNLIKQVEAKIEQAKEHKNKIYGS--------LEDKQIDDEIKKIEQIKEEISN 1370


                  ....*.
gi 1147813   1832 LEDELN 1837
Cdd:PTZ00440 1371 KRKEIN 1376
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1409-1718 5.97e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.81  E-value: 5.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQvtqmRTEESVRYKQSLDDAAKTIQDKNKEIERLKQ 1488
Cdd:COG4372   26 IAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQ----ARSELEQLEEELEELNEQLQAAQAELAQAQE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1489 LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRidyERVSQERTVKDQDITRFQNSLKelQL 1568
Cdd:COG4372  102 ELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEEL---KELEEQLESLQEELAALEQELQ--AL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1569 QKQKVEEELNRLKRTAsedscKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQ 1648
Cdd:COG4372  177 SEAEAEQALDELLKEA-----NRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEEL 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1649 RTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHL 1718
Cdd:COG4372  252 LEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAAL 321
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1311-1405 6.08e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 41.41  E-value: 6.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1311 QSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINIT-----KTTIHQLTMQKE 1385
Cdd:cd16269  191 QALTEKEKEIEAERAKAEAAEQERKLLEEQQRELEQKLEDQERSYEEHLRQLKEKMEEERENLlkeqeRALESKLKEQEA 270

                         90       100
                 ....*....|....*....|
gi 1147813  1386 EDTSGYRAQIDNLTRENRSL 1405
Cdd:cd16269  271 LLEEGFKEQAELLQEEIRSL 290
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1432-1678 6.50e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.74  E-value: 6.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1432 QQKATGSEVSQRKQQLEVELRQVTQMRTEesvrykqsLDDAAKTIQDKNKEIERLKQLIDKetndrkcLEDENARLQRvq 1511
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAE--------LEELNEEYNELQAELEALQAEIDK-------LQAEIAEAEA-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1512 yDLQKANSSATETINKLKVQEQELTRLRI--------DY-ERVSQERTVKDQD---ITRFQNSLKELQLQKQKVEEELNR 1579
Cdd:COG3883   80 -EIEERREELGERARALYRSGGSVSYLDVllgsesfsDFlDRLSALSKIADADadlLEELKADKAELEAKKAELEAKLAE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1580 LKrtasedsckrkKLEEELEGMRRSLKEQAIKITNLTQQLEQasivkkrseddlrqqrdvldghlrEKQRTQEELRRLSS 1659
Cdd:COG3883  159 LE-----------ALKAELEAAKAELEAQQAEQEALLAQLSA------------------------EEAAAEAQLAELEA 203

                        250
                 ....*....|....*....
gi 1147813  1660 EVEALRRQLLQEQESVKQA 1678
Cdd:COG3883  204 ELAAAEAAAAAAAAAAAAA 222
ADIP pfam11559
Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at ...
 1458-1565 6.82e-03

Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at cell-cell adherens junctions, and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins localized at Cell-Cell Adherens Junctions.


Pssm-ID: 463295 [Multi-domain]  Cd Length: 151  Bit Score: 39.61  E-value: 6.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1458 RTEESVRYKQSLddaAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANssaTETINKLKVQEQELTR 1537
Cdd:pfam11559   46 QRDRDLEFRESL---NETIRTLEAEIERLQSKIERLKTQLEDLERELALLQAKERQLEKKL---KTLEQKLKNEKEELQR 119

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1147813    1538 LRIDYERVSQERTV----KDQDITRFQNSLKE 1565
Cdd:pfam11559  120 LKNALQQIKTQFAHevkkRDREIEKLKERLAQ 151
Caldesmon pfam02029
Caldesmon;
1263-1596 7.02e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 41.78  E-value: 7.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1263 ATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW 1342
Cdd:pfam02029    8 ARERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKREERRQKRLQEALERQK 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1343 EYENELSKVRNNYDEEiislKNQFETEINIT-----KTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEikRLKNTLT 1417
Cdd:pfam02029   88 EFDPTIADEKESVAER----KENNEEEENSSwekeeKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEE--EGEEEED 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1418 QTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR 1497
Cdd:pfam02029  162 KSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEEAE 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1498 KCLEDENaRLQRVQYDLQKANSSATETInKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQnslkELQLQKQKVEEEL 1577
Cdd:pfam02029  242 VFLEAEQ-KLEELRRRRQEKESEEFEKL-RQKQQEAELELEELKKKREERRKLLEEEEQRRKQ----EEAERKLREEEEK 315

                          330       340
                   ....*....|....*....|...
gi 1147813    1578 NRLK----RTASEDSCKRKKLEE 1596
Cdd:pfam02029  316 RRMKeeieRRRAEAAEKRQKLPE 338
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1733-1938 7.43e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.96  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1733 DLRRGRSEADSDKNATILELRSQL------QISNNRTLELQGLINDLQRERENLRQEI--EKFQKQALEASNRIQESkNQ 1804
Cdd:PRK10929   31 ELEQAKAAKTPAQAEIVEALQSALnwleerKGSLERAKQYQQVIDNFPKLSAELRQQLnnERDEPRSVPPNMSTDAL-EQ 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1805 ctQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKStLEAETRvKQRLECEKQ-QIQND----LNQWKTQYSRKEEAIR 1879
Cdd:PRK10929  110 --EILQVSSQLLEKSRQAQQEQDRAREISDSLSQLPQ-QQTEAR-RQLNEIERRlQTLGTpntpLAQAQLTALQAESAAL 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147813   1880 KIESEREKSEREKNSLRSEIERLQAEI-KRIEERCRRKLED--STRETQSQLETERSRYQRE 1938
Cdd:PRK10929  186 KALVDELELAQLSANNRQELARLRSELaKKRSQQLDAYLQAlrNQLNSQRQREAERALESTE 247
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1156-1343 7.61e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 7.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1156 QKLESEkaIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYnEEMSNLRNKYETEINITKTTIKEISmQKEDDSKNL 1235
Cdd:COG1579   13 QELDSE--LDRLEHRLKELPAELAELEDELAALEARLEAAKTEL-EDLEKEIKRLELEIEEVEARIKKYE-EQLGNVRNN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1236 RnQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEEnalqqkacgseimqKKQHLEIELKQVMQQRSEDNARHKQSLEE 1315
Cdd:COG1579   89 K-EYEALQKEIESLKRRISDLEDEILELMERIEELEE--------------ELAELEAELAELEAELEEKKAELDEELAE 153

                        170       180
                 ....*....|....*....|....*...
gi 1147813  1316 AAKTIQDKNKEIERLKAEFQEEAKRRWE 1343
Cdd:COG1579  154 LEAELEELEAEREELAAKIPPELLALYE 181
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1414-1720 7.82e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 41.05  E-value: 7.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1414 NTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKe 1493
Cdd:COG1340    1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEE- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1494 tndrkcLEDENARLQRVQydlqkanssatETINKLKVQEQELTRLRIDYERVSQErtvKDQDITRFQNSL------KELQ 1567
Cdd:COG1340   80 ------RDELNEKLNELR-----------EELDELRKELAELNKAGGSIDKLRKE---IERLEWRQQTEVlspeeeKELV 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1568 LQKQKVEEELNRLKRtASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQA--SIVKKRSE-DDLRQQRDVLDGHL 1644
Cdd:COG1340  140 EKIKELEKELEKAKK-ALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELheEMIELYKEaDELRKEADELHKEI 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1147813  1645 REKqrtQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKsrSLNESKIEIERLQSLTENLTKEHLML 1720
Cdd:COG1340  219 VEA---QEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKE--ELEEKAEEIFEKLKKGEKLTTEELKL 289
PRK01156 PRK01156
chromosome segregation protein; Provisional
 707-1281 8.02e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.81  E-value: 8.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    707 NELKSVQNDSQAIAEVLNQLKDMLANF-----RGSEKYCYLQNEVFGLFQKLENINGVTDgYLNSLCTVRALLQAILQTE 781
Cdd:PRK01156  190 EKLKSSNLELENIKKQIADDEKSHSITlkeieRLSIEYNNAMDDYNNLKSALNELSSLED-MKNRYESEIKTAESDLSME 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    782 DMLKVYEARLtEEETVCLDLDKVEAYR---CGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSqqyplydlDLGKfge 858
Cdd:PRK01156  269 LEKNNYYKEL-EERHMKIINDPVYKNRnyiNDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLS--------VLQK--- 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    859 kvtqltDRWQRIDKQIdfRLWDLEKQIKQLRNYRDNYQAFCKWLYDRKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
Cdd:PRK01156  337 ------DYNDYIKKKS--RYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIK 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    939 GKRdksEEVQKiaelcanSIKDYELQLASYTSGLETLLN--IPIKRTM-IQSPSGVILQEAADVHARYIELLTRsgDYYr 1015
Cdd:PRK01156  409 KEL---NEINV-------KLQDISSKVSSLNQRIRALREnlDELSRNMeMLNGQSVCPVCGTTLGEEKSNHIIN--HYN- 475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1016 flsemlkslEDLKLKNTKIEVLEEElrlARDANSENCNKNKFLD----QNLQKYQAECSQFKAKLASLEELK-RQAELDG 1090
Cdd:PRK01156  476 ---------EKKSRLEEKIREIEIE---VKDIDEKIVDLKKRKEylesEEINKSINEYNKIESARADLEDIKiKINELKD 543

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1091 KSAKQNldkcygqikELNEKITRLTYEIEDEKR----RRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES------ 1160
Cdd:PRK01156  544 KHDKYE---------EIKNRYKSLKLEDLDSKRtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIgfpddk 614

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1161 ---EKAIKEKEYEIERLRVLLQEEGTRKREYEnELAKVRNHYNEEMSNLRnkyetEINITKTTIKEISMQKEDDSKNLRN 1237
Cdd:PRK01156  615 syiDKSIREIENEANNLNNKYNEIQENKILIE-KLRGKIDNYKKQIAEID-----SIIPDLKEITSRINDIEDNLKKSRK 688

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1147813   1238 QLD-------RLSRENRDLKDEIVRLNDSIlqaTEQRRRAEENALQQKACG 1281
Cdd:PRK01156  689 ALDdakanraRLESTIEILRTRINELSDRI---NDINETLESMKKIKKAIG 736
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1262-1345 8.17e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 41.33  E-value: 8.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1262 QATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSlEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
Cdd:PRK09510   70 QQKSAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQA-EEAAKQAALKQKQAEEAAAKAAAAAKAK 148


                  ....
gi 1147813   1342 WEYE 1345
Cdd:PRK09510  149 AEAE 152
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1644-1819 8.87e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 8.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1644 LREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLML--E 1721
Cdd:COG1579    9 LLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVrnN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1722 EELRNLRLEYDDLRRGRSEADSDknatILELRSQLQisnnrtlELQGLINDLQRERENLRQEIEKFQKqalEASNRIQES 1801
Cdd:COG1579   89 KEYEALQKEIESLKRRISDLEDE----ILELMERIE-------ELEEELAELEAELAELEAELEEKKA---ELDEELAEL 154

                        170
                 ....*....|....*...
gi 1147813  1802 KNQCTQVVQERESLLVKI 1819
Cdd:COG1579  155 EAELEELEAEREELAAKI 172
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 1403-1599 9.05e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 40.40  E-value: 9.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1403 RSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELR------QVTQMRTEESVRYKQSLDDAAKTI 1476
Cdd:pfam00261    4 QQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELErteerlAEALEKLEEAEKAADESERGRKVL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1477 QDK-NKEIERLKQL---------IDKETnDRKCLEDENaRLQRVQYDLQKANSSATETINKLKVQEQELT-------RLR 1539
Cdd:pfam00261   84 ENRaLKDEEKMEILeaqlkeakeIAEEA-DRKYEEVAR-KLVVVEGDLERAEERAELAESKIVELEEELKvvgnnlkSLE 161

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147813    1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTAS--EDS-----CKRKKLEEELE 1599
Cdd:pfam00261  162 ASEEKASEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDrlEDEleaekEKYKAISEELD 228
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1281-1612 9.36e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 9.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1281 GSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD---E 1357
Cdd:COG4372    1 GDRLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEqleE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1358 EIISLKNQFETEINITKTTIHQLTmQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKntltqttENLRRVEEDIQQQKAtg 1437
Cdd:COG4372   81 ELEELNEQLQAAQAELAQAQEELE-SLQEEAEELQEELEELQKERQDLEQQRKQLE-------AQIAELQSEIAEREE-- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1438 sEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKA 1517
Cdd:COG4372  151 -ELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEA 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813  1518 NSSATETINKLKVQEQELTRLrIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEE 1597
Cdd:COG4372  230 KLGLALSALLDALELEEDKEE-LLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALS 308

                        330
                 ....*....|....*
gi 1147813  1598 LEGMRRSLKEQAIKI 1612
Cdd:COG4372  309 LIGALEDALLAALLE 323
growth_prot_Scy NF041483
polarized growth protein Scy;
1223-1956 9.56e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 41.74  E-value: 9.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1223 EISMQKEDDSKNLRNQLDRL----SRENRDLKDEIVRlndsILQateqrRRAEENALQQKACGSEIMQKKQHLEIELKQV 1298
Cdd:NF041483   69 DIGYQAEQLLRNAQIQADQLradaERELRDARAQTQR----ILQ-----EHAEHQARLQAELHTEAVQRRQQLDQELAER 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1299 MQQ-----------------RSEDNARH--KQSLEEAAKTIQDKNKEIERLKaefqEEAKRRWEYENELSKV-------R 1352
Cdd:NF041483  140 RQTveshvnenvawaeqlraRTESQARRllDESRAEAEQALAAARAEAERLA----EEARQRLGSEAESARAeaeailrR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1353 NNYDEEiiSLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTR--ENRsLSEEIKRLKNTLTQTTENLRRVEEDI 1430
Cdd:NF041483  216 ARKDAE--RLLNAASTQAQEATDHAEQLRSSTAAESDQARRQAAELSRaaEQR-MQEAEEALREARAEAEKVVAEAKEAA 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1431 QQQKATG-SEVSQRKQQLEVELRQVTQMRTEESVRYK----QSLDDA---AKTIQDKNKEIERLKQLIDKETNDRKCLED 1502
Cdd:NF041483  293 AKQLASAeSANEQRTRTAKEEIARLVGEATKEAEALKaeaeQALADAraeAEKLVAEAAEKARTVAAEDTAAQLAKAART 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1503 ENARLQRVQYDLQKANSSATETINKLKVQ-EQELTRLRIDYERVSQERTVKDQDITrfqnslKELQLQKQKVEEELNRLK 1581
Cdd:NF041483  373 AEEVLTKASEDAKATTRAAAEEAERIRREaEAEADRLRGEAADQAEQLKGAAKDDT------KEYRAKTVELQEEARRLR 446

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1582 RTASEdscKRKKLEEELEGMRRSLKEQAIkitnltQQLEQAS------IVKKRSE-DDLRQQRDVLDGHLRE-------- 1646
Cdd:NF041483  447 GEAEQ---LRAEAVAEGERIRGEARREAV------QQIEEAArtaeelLTKAKADaDELRSTATAESERVRTeaieratt 517

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1647 -KQRTQEELRRLSSEVEALRRQLLQEQESVKQA------HLRNEHfQKAIEDKSrslNESKIEIERLQSLTEnltkEHLM 1719
Cdd:NF041483  518 lRRQAEETLERTRAEAERLRAEAEEQAEEVRAAaeraarELREET-ERAIAARQ---AEAAEELTRLHTEAE----ERLT 589

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1720 -LEEELRNLRLEYDDLRRGRSEaDSDKNATILELRSqlqisnnRTLELQGlindlQRERENLRQEiekfqkQALEASNRI 1798
Cdd:NF041483  590 aAEEALADARAEAERIRREAAE-ETERLRTEAAERI-------RTLQAQA-----EQEAERLRTE------AAADASAAR 650

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1799 QESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDEL------NRAKSTLEA--ETRVKQRLECEKqqiqndlnqwkTQ 1870
Cdd:NF041483  651 AEGENVAVRLRSEAAAEAERLKSEAQESADRVRAEAAAaaervgTEAAEALAAaqEEAARRRREAEE-----------TL 719

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813   1871 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR-IEERCRRKLE-------------DSTRETQSQLETE----- 1931
Cdd:NF041483  720 GSARAEADQERERAREQSEELLASARKRVEEAQAEAQRlVEEADRRATElvsaaeqtaqqvrDSVAGLQEQAEEEiaglr 799

                         810       820       830
                  ....*....|....*....|....*....|....*
gi 1147813   1932 ----------RSRYQREIDKLRQRPYgSHRETQTE 1956
Cdd:NF041483  800 saaehaaertRTEAQEEADRVRSDAY-AERERASE 833
MAP65_ASE1 pfam03999
Microtubule associated protein (MAP65/ASE1 family);
1158-1318 9.90e-03

Microtubule associated protein (MAP65/ASE1 family);


Pssm-ID: 427641 [Multi-domain]  Cd Length: 477  Bit Score: 41.14  E-value: 9.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1158 LESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRnhynEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRN 1237
Cdd:pfam03999  194 CESEDNFCLSRENIDKLRKLIKQLEEQKAEREEKIDDLR----EKILELWNRLQVPQEEQESFVRENNSLSQDTIDALRE 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147813    1238 QLDRLS---REN-----RDLKDEIVRLNDSILQATEQRRRA--------EENALQQkaCGSEIMQKKQHLEI--ELKQVM 1299
Cdd:pfam03999  270 ELQRLEelkKKNikkliEDLRVEIEELWDKLFYSTEQRKRFipffeelyTEDLLEL--HELELKRLKEEYESnkEILELV 347

                          170
                   ....*....|....*....
gi 1147813    1300 QQRsEDNARHKQSLEEAAK 1318
Cdd:pfam03999  348 EKW-EELWEDMEELEAKAN 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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