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Conserved domains on  [gi|1147708559|dbj|BAW99019|]
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valyl-tRNA synthetase, partial [Sulfurimonas sp. M70]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
valS super family cl35374
valyl-tRNA synthetase; Reviewed
 1-164 2.77e-105

valyl-tRNA synthetase; Reviewed


The actual alignment was detected with superfamily member PRK05729:

Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 320.13  E-value: 2.77e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPDDERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILN 80
Cdd:PRK05729  225 GDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTIN 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  81 DYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKFFP 159
Cdd:PRK05729  305 ENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKmKPLAKPALEAVENGEIKFVP 384


                  ....*
gi 1147708559 160 PHWIN 164
Cdd:PRK05729  385 ERWEK 389
 
Name Accession Description Interval E-value
valS PRK05729
valyl-tRNA synthetase; Reviewed
 1-164 2.77e-105

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 320.13  E-value: 2.77e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPDDERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILN 80
Cdd:PRK05729  225 GDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTIN 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  81 DYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKFFP 159
Cdd:PRK05729  305 ENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKmKPLAKPALEAVENGEIKFVP 384


                  ....*
gi 1147708559 160 PHWIN 164
Cdd:PRK05729  385 ERWEK 389
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
 1-164 6.05e-104

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 316.61  E-value: 6.05e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPDDERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILN 80
Cdd:COG0525   224 GDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTIN 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  81 DYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKFFP 159
Cdd:COG0525   304 ENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKmKPLAKPAIEAVEDGEIKFVP 383


                  ....*
gi 1147708559 160 PHWIN 164
Cdd:COG0525   384 ERWEK 388
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
 1-164 3.45e-87

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 272.32  E-value: 3.45e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPDDERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILN 80
Cdd:TIGR00422 223 GDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLN 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  81 DYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKFFP 159
Cdd:TIGR00422 303 ENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKvEKLADKALEAAEEGEIKFVP 382


                  ....*
gi 1147708559 160 PHWIN 164
Cdd:TIGR00422 383 KRMEK 387
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
 1-163 1.42e-54

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 181.07  E-value: 1.42e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPD-------------------------------DERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVK 49
Cdd:pfam00133 214 GNTAVAVNPEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVH 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  50 VTPAHDQNDYEVGKRHDLEFITVFDEKGILNDYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVE 129
Cdd:pfam00133 294 IAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPII 373

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1147708559 130 PYISKQWFVR-KEVAD---KSIEKT----NAGEAKFFppHWI 163
Cdd:pfam00133 374 PRATPQWFVRmDELADqalEAVEKVqfvpKSGEKRYF--NWL 413
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
 121-164 4.57e-12

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 62.65  E-value: 4.57e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1147708559 121 CYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKFFPPHWIN 164
Cdd:cd00817   156 CSRSGDVIEPLLKPQWFVKvKDLAKKALEAVKEGDIKFVPERMEK 200
 
Name Accession Description Interval E-value
valS PRK05729
valyl-tRNA synthetase; Reviewed
 1-164 2.77e-105

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 320.13  E-value: 2.77e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPDDERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILN 80
Cdd:PRK05729  225 GDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTIN 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  81 DYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKFFP 159
Cdd:PRK05729  305 ENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKmKPLAKPALEAVENGEIKFVP 384


                  ....*
gi 1147708559 160 PHWIN 164
Cdd:PRK05729  385 ERWEK 389
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
 1-164 6.05e-104

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 316.61  E-value: 6.05e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPDDERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILN 80
Cdd:COG0525   224 GDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTIN 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  81 DYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKFFP 159
Cdd:COG0525   304 ENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKmKPLAKPAIEAVEDGEIKFVP 383


                  ....*
gi 1147708559 160 PHWIN 164
Cdd:COG0525   384 ERWEK 388
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
 1-164 3.45e-87

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 272.32  E-value: 3.45e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPDDERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILN 80
Cdd:TIGR00422 223 GDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLN 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  81 DYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKFFP 159
Cdd:TIGR00422 303 ENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKvEKLADKALEAAEEGEIKFVP 382


                  ....*
gi 1147708559 160 PHWIN 164
Cdd:TIGR00422 383 KRMEK 387
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
 1-164 2.23e-65

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 214.87  E-value: 2.23e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPDDERYKDIIGKELVLPLL-DRKIKIIADS-YVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGI 78
Cdd:PTZ00419  267 GDVAVAVHPKDERYKKLHGKELIHPFIpDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGK 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  79 LNDYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKF 157
Cdd:PTZ00419  347 INENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNcKDMAKRAVEAVRNGELKI 426


                  ....*..
gi 1147708559 158 FPPHWIN 164
Cdd:PTZ00419  427 IPSSHEN 433
valS PRK14900
valyl-tRNA synthetase; Provisional
 1-164 1.41e-59

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 199.06  E-value: 1.41e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559    1 GDTAVMVHPDDERYKDIIGKELVLPLLDRKIKIIADS-YVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGIL 79
Cdd:PRK14900   239 GDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAiLVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRM 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   80 NDYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVRKE-VADKSIEKTNAGEAKFF 158
Cdd:PRK14900   319 TAEAGPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEpLARPAIEAVEQGRTRFI 398


                   ....*.
gi 1147708559  159 PPHWIN 164
Cdd:PRK14900   399 PEQWTN 404
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
 1-163 1.42e-54

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 181.07  E-value: 1.42e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPD-------------------------------DERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVK 49
Cdd:pfam00133 214 GNTAVAVNPEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVH 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  50 VTPAHDQNDYEVGKRHDLEFITVFDEKGILNDYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVE 129
Cdd:pfam00133 294 IAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPII 373

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1147708559 130 PYISKQWFVR-KEVAD---KSIEKT----NAGEAKFFppHWI 163
Cdd:pfam00133 374 PRATPQWFVRmDELADqalEAVEKVqfvpKSGEKRYF--NWL 413
PLN02381 PLN02381
valyl-tRNA synthetase
 1-159 4.30e-47

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 163.53  E-value: 4.30e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559    1 GDTAVMVHPDDERYKDIIGKELVLPLLDRKIKIIADS-YVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGIL 79
Cdd:PLN02381   334 GDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDAiLVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKI 413

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   80 NDYAG-EFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAK- 156
Cdd:PLN02381   414 NSNGGsEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNcSSMAKQALDAAIDGENKk 493


                   ....*
gi 1147708559  157 --FFP 159
Cdd:PLN02381   494 leFIP 498
valS PRK13208
valyl-tRNA synthetase; Reviewed
 4-164 2.47e-46

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 160.74  E-value: 2.47e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   4 AVMVHPDDERYKDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILNDYA 83
Cdd:PRK13208  226 AVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAA 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  84 GEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVR-KEVADKSIEKTNagEAKFFPPH- 161
Cdd:PRK13208  306 GKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKvLDLKEELLERGK--EINWYPEHm 383


                  ....*....
gi 1147708559 162 ------WIN 164
Cdd:PRK13208  384 rvrlenWIE 392
PLN02943 PLN02943
aminoacyl-tRNA ligase
 1-163 5.09e-41

aminoacyl-tRNA ligase


Pssm-ID: 215509 [Multi-domain]  Cd Length: 958  Bit Score: 145.85  E-value: 5.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPDDERYKDIIGKELVLPL-LDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGIL 79
Cdd:PLN02943  278 GDVAIAVNPEDDRYSKYIGKMAIVPMtYGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTL 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  80 NDYAGEFkgmeRLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNIVEPYISKQWFVRKE-VADKSIEKTNAGEAKFF 158
Cdd:PLN02943  358 NEVAGLY----WFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEpLAEKALKAVENGELTII 433

                         170
                  ....*....|..
gi 1147708559 159 PP-------HWI 163
Cdd:PLN02943  434 PErfekiynHWL 445
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
 1-161 1.05e-27

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 107.86  E-value: 1.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   1 GDTAVMVHPD----------DERYkdIIGKELV----------------------------------LPLLDRKIKIIAD 36
Cdd:COG0060   242 ANLAVAVHPDidyvlvevtgGERL--ILAEALVeavlkelgiedyevlatfkgaeleglryehpfyyVVGYDRAHPVILG 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  37 SYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILNDYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKH 116
Cdd:COG0060   320 DYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITH 399

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1147708559 117 QVGHCYRCKNivePYI---SKQWFVR----KEVADKSIEKTNageakFFPPH 161
Cdd:COG0060   400 SYPHCWRCKT---PLIyraTPQWFISmdklRDRALEAIEKVN-----WIPEW 443
PLN02843 PLN02843
isoleucyl-tRNA synthetase
 25-137 4.04e-15

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 71.73  E-value: 4.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  25 PLLDRKIKIIAD-SYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITVFDEKGILNDYAGEFKGMERL-EAREPIVQRL 102
Cdd:PLN02843  317 PLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLgEGNAAVVEAL 396

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1147708559 103 QEEGYIVKIEDHKHQVGHCYRCKnivEPYI---SKQWF 137
Cdd:PLN02843  397 DEAGSLLMEEAYGHKYPYDWRTK---KPTIfraTEQWF 431
tRNA-synt_1_2 pfam13603
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ...
 25-102 1.48e-12

Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.


Pssm-ID: 433342 [Multi-domain]  Cd Length: 185  Bit Score: 62.18  E-value: 1.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  25 PLLDRKIKI-IADsYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITV----------------FDEKGILNDyAGEFK 87
Cdd:pfam13603  92 PITGEKIPIwIAN-FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPViqpedgdldldimteaYTEEGILVN-SGEFD 169

                          90
                  ....*....|....*
gi 1147708559  88 GMERLEAREPIVQRL 102
Cdd:pfam13603 170 GLDSEEAKEAIIKKL 184
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
 121-164 4.57e-12

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 62.65  E-value: 4.57e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1147708559 121 CYRCKNIVEPYISKQWFVR-KEVADKSIEKTNAGEAKFFPPHWIN 164
Cdd:cd00817   156 CSRSGDVIEPLLKPQWFVKvKDLAKKALEAVKEGDIKFVPERMEK 200
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
 15-149 1.23e-09

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 56.03  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  15 KDIIGKELVLPLLDRKIKIIADSYVDMEFGTGVVKVTPAHDQNDY----EVGKRHDL----EFITV-------------- 72
Cdd:PRK12300  232 SELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELldviEPIPLievegygefpakev 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  73 ---------FDE---------------KGILNDYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCyRCKN-I 127
Cdd:PRK12300  312 veklgiksqEDPeleeatkevyraefhKGVLKENTGEYAGKPVREAREKITKDLIEKGIADIMYEFSNRPVYC-RCGTeC 390

                         170       180
                  ....*....|....*....|....*...
gi 1147708559 128 VEPYISKQWFVR------KEVADKSIEK 149
Cdd:PRK12300  391 VVKVVKDQWFIDysdpewKELAHKALDN 418
PLN02882 PLN02882
aminoacyl-tRNA ligase
 15-141 3.46e-09

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 54.73  E-value: 3.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   15 KDIIGKELV----LPLLD-------RKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRHDL-----EFITVFDEKGI 78
Cdd:PLN02882   290 AKVPGSSLVgkkyEPLFDyfsefsdTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIiekggNLPVPVDDDGC 369

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1147708559   79 LNDYAGEFKGMERLEAREPIVQRLQEEGYIVKIEDHKHQVGHCYRCKNivePYISK---QWFVRKE 141
Cdd:PLN02882   370 FTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSDT---PLIYRavpSWFVKVE 432
PTZ00427 PTZ00427
isoleucine-tRNA ligase, putative; Provisional
 28-163 5.87e-08

isoleucine-tRNA ligase, putative; Provisional


Pssm-ID: 173617 [Multi-domain]  Cd Length: 1205  Bit Score: 51.12  E-value: 5.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559   28 DRKIKIIADSYVDMEFGTGVVKVTPAHDQNDYEVGKRH---DLE---FITVFDEKGILNDYAGEFKGMERLEAREPIVQR 101
Cdd:PTZ00427   417 ERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNgviDPEkniFIDPLDANGYFTNEVEEVQNLYIKEADNVIKKK 496

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1147708559  102 LQEEGYIVKIEDHKHQVGHCYRCKNivePYISK---QWFVRKEVADKSIEKTNagEAKFFPPHWI 163
Cdd:PTZ00427   497 LKNENRLLSNNTIVHSYPFCWRSDT---PLIYRaipAWFIRVSNSTNELVKNN--ETTYWIPAHI 556
PLN02563 PLN02563
aminoacyl-tRNA ligase
 25-106 2.60e-05

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 43.27  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147708559  25 PLLDRKIKI-IADsYVDMEFGTGVVKVTPAHDQNDYEVGKRHDLEFITV--------------FDEKG-ILND--YAGEF 86
Cdd:PLN02563  396 PATGEAIPIwVAD-YVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVvkpadgneddaekaYTGEGvIVNSssSGLDI 474

                          90       100
                  ....*....|....*....|
gi 1147708559  87 KGMERLEAREPIVQRLQEEG 106
Cdd:PLN02563  475 NGLSSKEAAKKVIEWLEETG 494
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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