NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1144656267|gb|ONX04382|]
View 

tetracycline resistance MFS efflux pump, partial [Burkholderia cenocepacia]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 5-307 4.75e-103

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17388:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 385  Bit Score: 306.48  E-value: 4.75e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAA-TGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAAL 83
Cdd:cd17388     1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGdSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  84 DYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHLRAPFVA 163
Cdd:cd17388    81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 164 AALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWS 243
Cdd:cd17388   161 AAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1144656267 244 TPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALLP 307
Cdd:cd17388   241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILI 304
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 5-307 4.75e-103

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 306.48  E-value: 4.75e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAA-TGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAAL 83
Cdd:cd17388     1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGdSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  84 DYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHLRAPFVA 163
Cdd:cd17388    81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 164 AALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWS 243
Cdd:cd17388   161 AAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1144656267 244 TPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALLP 307
Cdd:cd17388   241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILI 304
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
4-306 4.90e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.14  E-value: 4.90e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   4 SLIAILATVLLDAIGVGIVMPILPGLLRSLAATGSTdthYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAAL 83
Cdd:COG2814    11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQ---AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  84 DYLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLG-ALHLRAPF 161
Cdd:COG2814    88 GSLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 162 VAAALLNALNLVLVWRVLPESRPRSAGGGRTAgalnpfanLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFG 241
Cdd:COG2814   168 LVNAVLALLALLLLLRLLPESRPAARARLRGS--------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1144656267 242 WSTPVAGLSLAGYGACHALAQaFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:COG2814   240 LSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303
2_A_01_02 TIGR00880
Multidrug resistance protein;
44-182 2.81e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 74.22  E-value: 2.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  44 GVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVAVAT-AYVTDVT 122
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1144656267 123 AEPDRARRFGQLGAMMGIGFIAGPLIGGLLG-ALHLRAPFVAAALLNALNLVLVWRVLPES 182
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAqFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
8-306 1.23e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 73.22  E-value: 1.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILATVLLDAIGVGIVMPILPGLLRSlaATGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLL 87
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE--DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  88 MALAPTLAWLYVGRLIAGIT-GANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGA-LHLRAPFVAAA 165
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 166 LLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFAnLRRLSGAPALAPLVGIYVIVALVSQAPATLWILygQEHFGWSTP 245
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY--QEVLGLSAL 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1144656267 246 VAGLSLaGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:pfam07690 236 LAGLLL-GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLL 295
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
21-152 1.12e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 40.29  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  21 IVMPILPGLLRSLAATGSTDTHY--GVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLY 98
Cdd:PRK09874   32 LVMPFLPLYVEQLGVTGHSALNMwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFL 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1144656267  99 VGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL 152
Cdd:PRK09874  112 ILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLL 165
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 5-307 4.75e-103

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 306.48  E-value: 4.75e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAA-TGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAAL 83
Cdd:cd17388     1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGdSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  84 DYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHLRAPFVA 163
Cdd:cd17388    81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 164 AALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWS 243
Cdd:cd17388   161 AAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1144656267 244 TPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALLP 307
Cdd:cd17388   241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILI 304
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 8-301 1.99e-41

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 146.57  E-value: 1.99e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILATVLLDAIGVGIVMPILPGLLRSLAATGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLL 87
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  88 MALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALH-LRAPFVAAAL 166
Cdd:cd17330    81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYgYALPFLVAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 167 LNALNLVLVWRVLpesrprsagggrtagalnpfanlrrlsgaPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWSTPV 246
Cdd:cd17330   161 LALLNLVLVLFFL-----------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQ 211

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1144656267 247 AGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWV 301
Cdd:cd17330   212 IGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPL 266
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 8-306 9.31e-34

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 126.92  E-value: 9.31e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILATVLLDAIGVGIVMPILPGLLRSLaatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLL 87
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESL---GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  88 MALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL-GALHLRAPFVAAA 165
Cdd:cd17325    78 FAFATSYWQLLLARFLQGLaSAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLaDALGYRAPFLVCA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 166 LLNALNLVLVWRVLPESRPRSAGGGRTAGalNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWSTP 245
Cdd:cd17325   158 ALALLALVLALLLLPEPRPPPNKRAVSAA--RLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1144656267 246 VAGLSLAGYGACHALAQAFAiGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:cd17325   236 QIGLLFGAQGLASALSQPPA-GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL 295
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 12-156 1.47e-27

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 109.62  E-value: 1.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  12 VLLDAIGVGIVMPILPGLLRSLaatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALA 91
Cdd:cd17390     5 GFLDLFGVSMILPLLSTHIRSL---GASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1144656267  92 PTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALH 156
Cdd:cd17390    82 TSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETD 146
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
4-306 4.90e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.14  E-value: 4.90e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   4 SLIAILATVLLDAIGVGIVMPILPGLLRSLAATGSTdthYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAAL 83
Cdd:COG2814    11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQ---AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  84 DYLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLG-ALHLRAPF 161
Cdd:COG2814    88 GSLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 162 VAAALLNALNLVLVWRVLPESRPRSAGGGRTAgalnpfanLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFG 241
Cdd:COG2814   168 LVNAVLALLALLLLLRLLPESRPAARARLRGS--------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1144656267 242 WSTPVAGLSLAGYGACHALAQaFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:COG2814   240 LSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 4-307 6.26e-21

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 91.90  E-value: 6.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   4 SLIAILATVLLDAIGVGIVMPILPGLLRSLaatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAAL 83
Cdd:cd17331     1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKL---GVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  84 DYLLMALAPTLAWLYVGRLIAgITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL-GALHLRAPFV 162
Cdd:cd17331    78 SYLLLAFASSVPMLFLSRLPS-VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLtKKFGEQAAAL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 163 AAALLNALNLVLVWRVLPES----RPRSAGGGRTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQE 238
Cdd:cd17331   157 VAAVGSLLSIVLVILLIPSNtkskREKEAKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMD 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1144656267 239 HFGWSTPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALLP 307
Cdd:cd17331   237 FFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLL 305
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 5-306 2.94e-20

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 89.55  E-value: 2.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAATgstDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALD 84
Cdd:cd17474     1 LYAVFFATLLAVLGVSIVDPILPAIAEALGAS---PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  85 YLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHLRAPFVA 163
Cdd:cd17474    78 GLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 164 AALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLwilygQEHFGWS 243
Cdd:cd17474   158 LAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLL-----ELLYGIS 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1144656267 244 TPVAGLSLAGYGACHALAqAFAIGPLIA-RLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:cd17474   233 PIIIGLLFAGWSVLLALG-SLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAI 295
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 5-157 3.91e-20

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 89.64  E-value: 3.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLL----------------------RSLAATGSTDTHYGVLL-----ALYAFAQFLC 57
Cdd:cd17389     1 ITIVFLALLLDLLAFTIILPLFPSLLdyygqnddsglyslqissvdwfRDAIGAPDERRYNSVLFggligSLFSLLQFLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  58 APLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAM 137
Cdd:cd17389    81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                         170       180
                  ....*....|....*....|
gi 1144656267 138 MGIGFIAGPLIGGLLGALHL 157
Cdd:cd17389   161 FSLGFIIGPMIGAYFASFTR 180
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 8-306 4.63e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 80.55  E-value: 4.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILATVLLDAIGVGIVMPILPGLLRSLaatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLL 87
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSF---GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  88 MALAPTLAWLYVGRLIAGITGANVAVAT-AYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL---GALHLRAPFVA 163
Cdd:cd06174    78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILassLGFGWRAVFLI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 164 AALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWS 243
Cdd:cd06174   158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1144656267 244 TPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:cd06174   238 VAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 5-301 2.43e-16

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 78.38  E-value: 2.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAATGSTDThyGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALD 84
Cdd:cd17473     1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLV--PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  85 YLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHLRAPFvA 163
Cdd:cd17473    79 GVAGLFLDSLYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPF-L 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 164 AALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANLRRLSGAPALApLVGIYVIVALVSQAPatlwiLYGQEHFGWS 243
Cdd:cd17473   158 VYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLA-FLAMLLFYVIPIQLP-----FLLQERGGGS 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1144656267 244 TPVAGLSLAGYGACHALAqAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWV 301
Cdd:cd17473   232 AALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWV 288
2_A_01_02 TIGR00880
Multidrug resistance protein;
44-182 2.81e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 74.22  E-value: 2.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  44 GVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVAVAT-AYVTDVT 122
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1144656267 123 AEPDRARRFGQLGAMMGIGFIAGPLIGGLLG-ALHLRAPFVAAALLNALNLVLVWRVLPES 182
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAqFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
8-306 1.23e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 73.22  E-value: 1.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILATVLLDAIGVGIVMPILPGLLRSlaATGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLL 87
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE--DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  88 MALAPTLAWLYVGRLIAGIT-GANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGA-LHLRAPFVAAA 165
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 166 LLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFAnLRRLSGAPALAPLVGIYVIVALVSQAPATLWILygQEHFGWSTP 245
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY--QEVLGLSAL 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1144656267 246 VAGLSLaGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:pfam07690 236 LAGLLL-GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLL 295
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 5-301 1.64e-14

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 73.03  E-value: 1.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAATGSTDThyGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALD 84
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIV--GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  85 YLLMALAPTLAWLYVGRLIAGITGANVAVA-TAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHLRAPFVA 163
Cdd:cd17329    79 FALLGFAHSPWLFAIALVLTGFGGGLFEPAsEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 164 AALLNALNLVLVWRVLPESRPRSagggRTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWS 243
Cdd:cd17329   159 AAVLFLLAALVLLFLLPETRPKR----RAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1144656267 244 TPVAGLSLAGYGACHALAQaFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWV 301
Cdd:cd17329   235 ESLLGLLLALNALLIVLLQ-FPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAV 291
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
5-307 1.84e-14

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 72.96  E-value: 1.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAATgstDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALD 84
Cdd:COG0738    10 LIAIYLLFFLWGFATALWGPLIPALKDAFGLS---DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  85 YLLMALAPTLAWLYVGRLIAGITGANV-AVATAYVTDVTAEpDRARRFGQLGAMMGIGFIAGPLIGGLLGALHL----RA 159
Cdd:COG0738    87 LLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLGLslswHL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 160 PFVAAALLNALNLVLVWRV-LPESRPRSAGGGRTAgalnpfANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQE 238
Cdd:COG0738   166 PYLILAVLLLLLALLFLRSkLPEIEEEEEEAAGSA------ASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1144656267 239 HFGWSTPVAGLSLAGYGACHALAQaFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALLP 307
Cdd:COG0738   240 VLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLA 307
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 5-302 1.93e-14

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 72.99  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAATGSTdTHY--GVLLALYAFAQFLcaplLGALSDRFGRRPVLLASLAGAA 82
Cdd:cd17320     1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASA-VQLtlSAYLLGFALGQLL----YGPLSDRFGRRPVLLAGLLLFI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  83 LDYLLMALAPTLAWLYVGRLIAGITGANVAV-ATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGA-LHLRAP 160
Cdd:cd17320    76 LASLLCALASSIEQLLIARFLQGLGAAAGSVvARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLfFGWRAI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 161 FVAAALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANL--RRLSGAPALAPLVGIYVIVALVSQAPATLwilygQE 238
Cdd:cd17320   156 FVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVlkNRRFLGYALALGLSFAGLFAYLAAAPFIY-----IE 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1144656267 239 HFGWSTPVAGLSLAGYGACHALAqAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVP 302
Cdd:cd17320   231 QLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGL 293
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-161 1.20e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 70.68  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   1 MNPSLIAILATVLLDAIGVGIVMPILPGLLRSLAatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAG 80
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG--GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  81 AALDYLLMALAPTLAWLYVGRLIAGITGANVAVAT-AYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL-GALHLR 158
Cdd:cd17325   275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLyDAFGFA 354


                  ...
gi 1144656267 159 APF 161
Cdd:cd17325   355 TPF 357
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 8-301 5.05e-13

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 68.77  E-value: 5.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILATVLLDAIGVGIVMPILPGLLRSLaatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLL 87
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDL---GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  88 MALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL-GALHLRAPFVAAA 165
Cdd:cd17489    78 YLLATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLyQHLGFAVLFIVAA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 166 LLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANLRRLSGAPALAPLVGIYVIValvsqapATLWILYGQEHFGWstp 245
Cdd:cd17489   158 VLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAI-------STFLPLYAAERGIS--- 227

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1144656267 246 VAGLSLAGYGACHALAQAFAiGPLIARLGERRALALGLAGDALGLAVIAFATAAWV 301
Cdd:cd17489   228 NAGLFFTVYAIALLLSRPFS-GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWM 282
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 10-152 7.69e-13

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 68.00  E-value: 7.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  10 ATVLLDAIGVGIVMPILPGLLRSLAATGSTdTHYGVLLALYAFAQFLCAPLLGALSDRFG--RRPVLLASLAGAALD--Y 85
Cdd:cd17326     6 LTMFLSSLQFSIVLTSIWPYLQKIDPTATA-SFFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPLIVSILIAIVGNilY 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1144656267  86 LLMALAPT--LAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL 152
Cdd:cd17326    85 ALAEYFPSnrKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAF 153
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 5-285 1.73e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 66.37  E-value: 1.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLaatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALD 84
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADL---GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  85 YLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL-GALHLRAPFV 162
Cdd:COG0477    93 SLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLvAALGWRWIFL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 163 AAALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGW 242
Cdd:COG0477   173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1144656267 243 STPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAG 285
Cdd:COG0477   253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 21-306 1.89e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 66.80  E-value: 1.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  21 IVMPILPGLLRSLAATGSTdthYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVG 100
Cdd:cd17324    17 VIQGLLPDIARDFGVSVAQ---AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 101 RLIAGIT-GANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLG-ALHLRAPFVAAALLNALNLVLVWRV 178
Cdd:cd17324    94 RALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGqLLGWRAAFLAIAVLALLAALLLWRL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 179 LPESRPrsagggRTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWSTPVAGLSLAGYGACH 258
Cdd:cd17324   174 LPSLPP------KKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1144656267 259 ALAqAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:cd17324   248 VVG-SPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGL 294
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
39-306 6.84e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 62.21  E-value: 6.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  39 TDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGIT-GANVAVATAY 117
Cdd:COG2223    38 SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGgGGSFAVGIAL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 118 VTDVTAEPDRARRFGQLGAMMGIG-FIAGPLIGGLLGALHLRAPFVAAALLNALNLVLVWRVLpesrpRSAGGGRTAGAL 196
Cdd:COG2223   118 VSKWFPPDRRGLALGLAAGGGNLGaAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFL-----RDPPAGAAAAAK 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 197 NPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWSTPVAGLSLAGYGACHALAQAFAiGPLIARLGER 276
Cdd:COG2223   193 ASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLG-GWLSDRIGGR 271

                         250       260       270
                  ....*....|....*....|....*....|
gi 1144656267 277 RALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:COG2223   272 RVLLIVFALMALGLLLLALALGSLWLFLVL 301
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 8-156 1.06e-10

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 61.81  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILATVLLDAIGVGIVMPILPGLLRSLAATGSTdTHYGVLLALYAFAQFLcaPLLGALSDRFGRRPVLLASLAGAALDYLL 87
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQ-LQWVVNAYLLAFAALL--LLAGRLGDRFGRKRVFLIGLALFGLASLL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  88 MALAPTLAWLYVGRLIAGITGAN-VAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALH 156
Cdd:cd17321    78 CALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF 147
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 44-300 1.70e-10

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 61.28  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  44 GVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTlaWLYVGRLIAGITGANVAVATAYVTDVTA 123
Cdd:cd17387    39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPW--WYFAMISVSGIFSVTFSVIFAYVADITT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 124 EPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHLRAPFVAAALLNALNLVLVWRV-LPES-----RPRSAGGGRTAGALN 197
Cdd:cd17387   117 EEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLaVPESlpekmRPASWGAPISWEQAD 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 198 PFANLRRlSGAPALAPLVGIYVIVALVSQA-PATLWILYGQEHFGWSTPVAGLSLAGYGACHALAQAFAIGPLIARLGER 276
Cdd:cd17387   197 PFASLRK-VGKDKTVLLICITVFLSYLPEAgQYSSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAK 275

                         250       260
                  ....*....|....*....|....
gi 1144656267 277 RALALGLAGDALGLAVIAFATAAW 300
Cdd:cd17387   276 NTILLGLGFQMLQLAWYGFGSQHW 299
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 18-154 3.71e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 59.92  E-value: 3.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  18 GVGIVMPILPGLLRSLAatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWL 97
Cdd:cd17472    11 GMFLVLPVLSVYAKSLP--GATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGL 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1144656267  98 YVGRLIAGItGANVAVATAYVTDVTAEPDRARRFGQLGAMMGI----GFIAGPLIGGLLGA 154
Cdd:cd17472    89 ILGRALQGS-GAISSVVMALLADLTREENRTKAMALIGASIGIafaiSMVLGPLLAAHLGV 148
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 58-152 2.71e-09

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 57.19  E-value: 2.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  58 APLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANV-AVATAYVTDVTAEPDRARRFGQLGA 136
Cdd:cd17502    47 QPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLVPPRERGKYQGYIGA 126

                          90
                  ....*....|....*.
gi 1144656267 137 MMGIGFIAGPLIGGLL 152
Cdd:cd17502   127 VFGIASVAGPLIGGAF 142
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
5-306 5.31e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.42  E-value: 5.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLaatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALD 84
Cdd:COG2271    12 LALLFLAYFLNYLDRSNLSVAAPPLQADL---GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  85 YLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGG-LLGALHLRAPFV 162
Cdd:COG2271    89 TLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGwLLAAFGWRAAFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 163 AAALLNAlnlvlvwrvlpesrprsagggrtagalnpfanlrrLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGW 242
Cdd:COG2271   169 ILGLPGL-----------------------------------LLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1144656267 243 STPVAGLSLAGYGACHALAqAFAIGPLIARLGERR--ALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:COG2271   214 SLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALL 278
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 13-187 7.47e-09

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 56.24  E-value: 7.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  13 LLDAIGVGIVMPILPGLLRSLAATGSTDTHYGVL-LALYAFAQFLcaplLGALSDRFGRRPVLLASLAGAALDYLLMALA 91
Cdd:TIGR00710  15 ILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLyLLGFAAGQLL----WGPLSDRYGRRPVLLLGLFIFALSSLGLALS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  92 PTLAWLYVGRLIAGITGANVAVAT-AYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGG-LLGALHLRAPFVAAALLNA 169
Cdd:TIGR00710  91 NNIETLLVLRFVQAFGASAGSVISqALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGyILVWLSWHAIFAFLSLAGI 170

                         170
                  ....*....|....*...
gi 1144656267 170 LNLVLVWRVLPESRPRSA 187
Cdd:TIGR00710 171 LLSALIFFILPETLPYEA 188
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 8-306 2.29e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 54.49  E-value: 2.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILATVLLDAIGVGIVMPILPglLRsLAATGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLL 87
Cdd:cd17477     1 LLLSVALLGLGSGLLLPLLS--LR-LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  88 MALAPTLAWLYVGRLIAGITGANVAVAT-AYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHLRAPFVAAAL 166
Cdd:cd17477    78 LALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 167 LNALNLVLVWRVLPESRPRSAGGGRtagalnpFANLRRLSGAPALAPLVGIYVIVALVSQAPatlwiLYGQEHfGWSTPV 246
Cdd:cd17477   158 LLLALVPLLLTRRAAPEIEEAESIS-------LRRLLRIAPLALLGAFVAGFLEGAFYSLLP-----LYGLRL-GLSVAQ 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1144656267 247 AGLSLAGYGACHALAQaFAIGPLIARLGERRALA----LGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:cd17477   225 AALLLAAFVLGGLLLQ-WPLGWLADRFDRRRVLLgcalLGALAALLLPLVPGLPLALLVLLFLW 287
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 13-152 3.07e-08

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 54.19  E-value: 3.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  13 LLDAIGVGIVMPILPGLLRSLAATGSTDTHY--GVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMAL 90
Cdd:cd17391     6 FFTGIGFSLIAPFLPLYIEQLGVTSGGLVELwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAF 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1144656267  91 APTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL 152
Cdd:cd17391    86 VTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFL 147
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 23-305 7.01e-08

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 52.99  E-value: 7.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  23 MPILPGLLRSLAATGSTdthYGVLLALYAFAQFLCAPLLGALSDRFGRR-PVLLASLAGAALDYLLMALAPTLAWLYVGR 101
Cdd:cd17490    16 VPFLSPYAESLGASLSM---IGIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIAR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 102 LIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLG-ALHLRAPFVAAALLNALNLVLVWRVLP 180
Cdd:cd17490    93 FLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFLLAALAGVLGFILSLFIKE 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 181 ESRPRSAGGGRTAGALNPFANlrrlsgapalaPLVGIYVIVALVSQApatlwILYGQEhFGWSTPVA----------GLS 250
Cdd:cd17490   173 ERREKKPVLTELKELLSVLKD-----------KKLLFFSLLAILQQM-----ITFSTT-FGFTPLIAkqlgassfqlGLL 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1144656267 251 LAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFAL 305
Cdd:cd17490   236 SIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLL 290
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 45-161 1.43e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 52.16  E-value: 1.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  45 VLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTA 123
Cdd:cd17370   238 LLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLyMGAQESIERAAVADLVP 317

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1144656267 124 EPDRARRFGQLGAMMGIG-FIAGPLIGGLLGALHLRAPF 161
Cdd:cd17370   318 AELRGTAYGLFNTVVGIGwLLASLIAGYLWDLISPSAAF 356
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 5-155 3.46e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.06  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAaTGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALD 84
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFS-LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1144656267  85 YLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGAL 155
Cdd:cd17316    80 TLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPL 151
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 44-306 3.57e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 51.08  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  44 GVLLALYAFAQFLCAPLLGALSDRFGRRPV-----LLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVAVA-TAY 117
Cdd:cd06173    37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPArQAL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 118 VTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL-GALHLRAPFVAAALLNALNLVLVWRvLPESRPRSAGGGRTAGAL 196
Cdd:cd06173   117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGAFAINALSFLLSALLLLF-IRRPPPAAPGESSSLLLR 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 197 NPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWSTPVAGLSLAGYGAcHALAQAFAIGPLIARLGER 276
Cdd:cd06173   196 DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV-GALLGALLLGRLSKRRRRG 274

                         250       260       270
                  ....*....|....*....|....*....|
gi 1144656267 277 RALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:cd06173   275 RLLLIGALLLGLALLVLGLSPSLWLLLAAL 304
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
44-307 5.37e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 5.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  44 GVLLALYAFAQFLCAPLLGALSDRFG-----RRPVLLASLAGAALDYLLMALAPT------LAWLYVGRLIAGITGANVA 112
Cdd:COG2211    49 GLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAYTLVN 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 113 VA-TAYVTDVTAEPDR------ARRFGQLGAMMGIGFIAGPLIGGLLG--ALHLRAPFVAAALLNALNLVLVWRVLPESR 183
Cdd:COG2211   129 IPySALGAELTPDYEErtrlssWRFAFAGLGGLLASVLPPPLVAAFGGdaALGYRLTALIFAVLGLLAFLLTFFGTKERP 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 184 PRsagggrTAGALNPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWSTPVAGLSLAGYGACHALAqA 263
Cdd:COG2211   209 VP------EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLG-A 281

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1144656267 264 FAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALLP 307
Cdd:COG2211   282 PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVL 325
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 3-161 7.14e-07

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 49.96  E-value: 7.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   3 PSLIAILATVLLDAIGVGIVMPILPGLLRSLAATGS-TDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGA 81
Cdd:cd17391   201 SLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASnLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLAS 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  82 ALDYLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGA-LHLRA 159
Cdd:cd17391   281 ALLYIPQAFVQTPWQLGILRFLLGLaTGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAhFGYRA 360


                  ..
gi 1144656267 160 PF 161
Cdd:cd17391   361 VF 362
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 58-295 2.70e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 48.34  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  58 APLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAM 137
Cdd:cd17504    48 TPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSAT 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 138 MGIGFIAGPLIGGLLgalhlrapfvaaallnalNLVLVWRVLPESrprSAGGGRTAGALNPFANLRRLSGAPALAPLVGI 217
Cdd:cd17504   128 FGIGAGIGLPLGGWI------------------VQHLGWRWIFWT---AAPVAVLLAALVPLIDLRLLRRRNVLLANITA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 218 YVIVALVSQAPATLWILYGQEH---FGWSTPVAGLSLAGYGACHALAQAFAiGPLIARLGERRALALGLAGDALGLAVIA 294
Cdd:cd17504   187 LLAGFGMFMVFQLLPQLLQLPTptgFGLGITEAGLLLLPGALVMLIAGPLA-GRLIARVGPRRVLLIGLVISAVGLLLLA 265


                  .
gi 1144656267 295 F 295
Cdd:cd17504   266 L 266
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 56-300 4.34e-06

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 47.66  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  56 LCAPLLGALSDRFGRRPVLLASLAGAALDYLLMAL------APTLAWLYVGRLIAGITGANVAV---ATAYVTDVTAEPD 126
Cdd:cd17386    45 FSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLivyfttVPSVWWFYLSAIPLALFGGFTAFlsaSFAYISDISSEKK 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 127 RARRFGQLGAMMGIG-FIAGPLIGGLLGALHLRAPFVAaallnalnlvlvwrvlpesrprsagggrtAGALNPFANLRRL 205
Cdd:cd17386   125 RTYRMAILEVALGLGgFLGSLLSGHLFKALGYAWSFSI-----------------------------SAALLLIALLYIL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 206 SGAPALAPLVGIYVIVALVSQAPATLWILYGQEHFGWSTPVAGL-SLAGYGachALAQAFAIGPLIARLGERRALA---- 280
Cdd:cd17386   176 FFLTLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYfSTLGSL---IYLTGMLGGVLLLRCLLKMSDStlam 252

                         250       260
                  ....*....|....*....|
gi 1144656267 281 LGLAGDALGLAVIAFATAAW 300
Cdd:cd17386   253 LGLASHILSSLLFAFATNTW 272
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 41-306 7.20e-06

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 47.24  E-value: 7.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  41 THYGVLLALYAFAQFLCAPLLGALSDR----FGRR-PVLLASLAGAALDYLLMALAPTLAWLYVGR--------LIAGIT 107
Cdd:cd17313    34 ALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRrPFILVGAPLAALGLILIPNAADIGLALGDGprtwalvlFVLGIV 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 108 GANVAVAT------AYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGAL---------HLRAPFVAAALLNALNL 172
Cdd:cd17313   114 LLDFAMNVcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHnwfgfalggNLKVPFYIGAIILLVCV 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 173 VLVWRVLPESRPRSAGGGRTAGALnPFANLRRLSGAPALAPLVGIYVIVALVS--------QAPATLWIlyGQEHF-GWS 243
Cdd:cd17313   194 LVTLFFVKEPPLSPEAGEHSENPS-LGEVLKSLLKLLKIMPRSLLRLLLVIFFwwiaffpfELFFTDYM--GEEVYhGTS 270

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1144656267 244 TPVAGLSLAGYGACHALAQ--------AFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:cd17313   271 AASSHYGAGVRMGAWGLLIfslaflifSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLF 341
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
5-306 1.66e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.02  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAATGSTdthYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALD 84
Cdd:COG2807    20 LLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQ---AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  85 YLLMALAPTLAWLYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGG-LLGALHLRAPFVA 163
Cdd:COG2807    97 LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVpLAAALGWRGALAV 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 164 AALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANlrrlsgapALAPLVGIYVIVALVSQAPATLWILYGQEHFGWS 243
Cdd:COG2807   177 WALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRS--------PLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLS 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1144656267 244 TPVAGLSLAGYGACHALAqAFAIGPLIARLGERRALALGLAG-DALGLAVIAFATAAWVPFALL 306
Cdd:COG2807   249 AATAGLLLSLFQLAGIPG-SLLVPLLADRLGDRRPLLLLLGLlGLAGLLGLLLAPGSLPWLWAV 311
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 20-306 2.08e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 45.62  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  20 GIVMPILPGLLRSLaatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYV 99
Cdd:cd17478    13 GFLPALLPLLIAKL---GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 100 GRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALHLRAPFVAAALLNALNLVLVWRVL 179
Cdd:cd17478    90 LVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 180 PESRPRSAGGGRTAGAlnpfANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHfGWSTPVAGLSLAGYGACHA 259
Cdd:cd17478   170 RPLKKPEAKKAAAKSS----ARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGA 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1144656267 260 LAQaFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFALL 306
Cdd:cd17478   245 IGT-LIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLV 290
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
2-152 2.41e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   2 NPSLIAILATVLLDAIGVGIVMPILPGLLRSLAatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGA 81
Cdd:COG2211   227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  82 ALDYLLMALAP--TLAWLYVGRLIAGIT-GANVAVATAYVTDVTAEPDRARRFGQLGAMMGI-------GFIAGPLIGGL 151
Cdd:COG2211   305 ALGLLLLFFLGpgNLWLLLVLAALAGIGlGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIftfaiklGQALAGALAGL 384


                  .
gi 1144656267 152 L 152
Cdd:COG2211   385 L 385
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 60-150 3.46e-05

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 45.18  E-value: 3.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  60 LLGALSDRFGRRPVLLASLAGAALD---YLL-MALAPTLAWLYVGRLIAGITG---ANVAVATAYVTDVTAEPDRARRFG 132
Cdd:cd17449    84 LLGPWSDSVGRRPVLILPSLGLALQaavYLLvMYLQLHVAYFLIGRILSGLLGdfnGILAGCFAYVADVSDRRSRTFRVA 163

                          90
                  ....*....|....*...
gi 1144656267 133 QLGAMMGIGFIAGPLIGG 150
Cdd:cd17449   164 VLEACLGLAGMLASIIGG 181
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 18-300 5.09e-05

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 44.50  E-value: 5.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  18 GVGIVMPILPGLLRSLaatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFG-RRPVLLASLAGAALDYLLMALAPTLAW 96
Cdd:cd17335    12 ALGSLLPFLSVYLKQL---GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFW 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  97 LYVGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAG-PLIGGLLGALHLRAPFVAAALLNALNLVLV 175
Cdd:cd17335    89 LLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAaLLVGILIDRSSTYKNYTIAFYVFAVLMLLA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 176 WRV---LPESRPRSAGGGRTAGALNPFANLRrlsgapalaplVGIYVIVALVSQAPATLWILYGQ---EHFGWSTPVAGL 249
Cdd:cd17335   169 LLLalkFPFRPKHPEPNENTGGLLALLRNPR-----------VLAFLLVAFLMGFGHGLIYSFLFwhlQDLGGSKTLIGL 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1144656267 250 SLAGYGACHALAQAFAiGPLIARLGERRALALGLAGDALGLAVIAFATAAW 300
Cdd:cd17335   238 LWTVGVVSEIPFFFFS-SRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPW 287
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 6-299 8.28e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.80  E-value: 8.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   6 IAILATVLLDAIGVGIVMPILPGLLRSLAATGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDY 85
Cdd:cd17355     3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  86 LLMALAPTLAWLYV--GRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIG-FIAGPLIGGLLGALHLRAPFV 162
Cdd:cd17355    83 VLLALATSLWQLYLlwGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGsLVFLPLGAALIEAFGWRTALL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 163 AAALLNALNLVLVWRVLPESRPRSAGGGRTAGAL-NPFANLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQEHfG 241
Cdd:cd17355   163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPaSPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-G 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1144656267 242 WSTPVAGLSLAGYGACHALAQAFaIGPLIARLGERRALALGLAGDALGLAVIAFATAA 299
Cdd:cd17355   242 ISPAAAAVALALIGLFNIVGRLL-SGWLGDRYSPRRLLAASYALRALGLALLLLLPFP 298
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 62-184 1.31e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 42.95  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  62 GALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVtAEPDRARRFGQLGAMMG- 139
Cdd:cd17315    55 GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLgVGLASVLVPLYISEI-APAKIRGALGTLNQLMIt 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1144656267 140 IGFIAGPLIGGLLG--ALHLRAPFVAAALLNALNLVLVWRVLPESRP 184
Cdd:cd17315   134 FGILLAYLLGLALSlsPPGWWRLMFALAAVPALLQLLLMFFLPESRA 180
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 8-155 3.14e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 42.18  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILAT--VLLDAIGVGIVMPILPGLLRSLAATGS-----TDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAG 80
Cdd:cd17358     1 LLATfvANLGSFSFGIAVGWSSPALPSLMSDNSlslplTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1144656267  81 AALDYLLMALAPTLAWLYVGRLIAGIT-GANVAVATAYVTDVTaepDRARRfGQLGAMMGIGFIAGPLIGGLLGAL 155
Cdd:cd17358    81 CILGWLLIAFAKDVWMLYLGRFLAGFGgGAASVVVPVYIAEIA---PKNVR-GALGSLNQLLVNIGILLGYVLGSF 152
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-141 3.55e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   2 NPSLIAILATVLLDAIGVGIVMPILPGLLRSLAatGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGA 81
Cdd:COG2814   206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL--GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1144656267  82 ALDYLLMALAPTLAWLYVGRLIAGIT-GANVAVATAYVTDVTAEPDRARRFGQLGAMMGIG 141
Cdd:COG2814   284 ALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 59-300 6.93e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.02  E-value: 6.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  59 PLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVA-VATAYVTDVTAEPDRARRFGQLGAM 137
Cdd:cd17503    49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVGLV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 138 MGIGFIAGPLIGG-LLGALHLRAPFVAAALLNALNLvlvwrvlpesrprsagggrtagALNPFANLRRLSGAPALAPLVG 216
Cdd:cd17503   129 ILLAPAIGPTLGGwLTDNLSWRWIFYINLPIGILAL----------------------LLAPLLDLRLFKDRNFTLGLLL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 217 IYVIVALVSQAPATLwILYGQEHFGWSTPVAGLSLAGYGachaLAQAFA---IGPLIARLGERRALALGLAGDALGLAVI 293
Cdd:cd17503   187 SFLLGLGLFGAMFLL-PLYLQNVLGYSAFESGLVLAPGG----LASAILsplVGRLLDKFGPRLLLLAGLLLLALGTLLL 261


                  ....*..
gi 1144656267 294 AFATAAW 300
Cdd:cd17503   262 AFLTPDT 268
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-152 8.85e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 8.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   1 MNPSLIAILATVLLDAIGVGIVMPILPGLLRSLAATgstdtHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAG 80
Cdd:cd17489   192 VEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS-----NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1144656267  81 AALDYLLMALAPTLAWLYVGRLIAGITGANVAVA-TAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL 152
Cdd:cd17489   267 LALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPAlQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
21-152 1.12e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 40.29  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  21 IVMPILPGLLRSLAATGSTDTHY--GVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLY 98
Cdd:PRK09874   32 LVMPFLPLYVEQLGVTGHSALNMwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFL 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1144656267  99 VGRLIAGITGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL 152
Cdd:PRK09874  112 ILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLL 165
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 60-155 1.61e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 39.87  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  60 LLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANV-AVATAYVTDVTAEPDRarrfgqlGAMM 138
Cdd:cd17323    53 IWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEER-------GKAM 125

                          90
                  ....*....|....*..
gi 1144656267 139 GIgFIAGPLIGGLLGAL 155
Cdd:cd17323   126 GV-YSLGPLLGPALGPI 141
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 5-182 1.68e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.65  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   5 LIAILATVLLDAIGVGIVMPILPGLLRSLAATGSTdthYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALD 84
Cdd:TIGR00895  19 IILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQ---LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  85 YLLMALAPTLAWLYVGRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGALH-LRAPFV 162
Cdd:TIGR00895  96 TLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFgWRSLFY 175

                         170       180
                  ....*....|....*....|
gi 1144656267 163 AAALLNALNLVLVWRVLPES 182
Cdd:TIGR00895 176 VGGIAPLLLLLLLMRFLPES 195
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 21-305 1.75e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  21 IVMPILPGLLRSLAATGSTdthYGVLLALYAFAQFLCAPLLGALSDRFGRR-PVLLASLAGAALDYLLMALAPTLAWLYV 99
Cdd:cd17370    17 MARSILPLFLVVLGASAAA---VGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 100 GRLIAGI-TGANVAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLL---GALHLRAPFVAAALLNALNLVLV 175
Cdd:cd17370    94 LRILERLgKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlylLGGNYRTIFLLAAIPALLALLIL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 176 WRVLPESRprsagggRTAGALNPFANLRRLSGAPALAPLVGIYVIVALvSQAPATLWILYGQEhFGWSTPVAGLSLAGYG 255
Cdd:cd17370   174 LFVVKEYP-------RPPKLRKKSKKTSLKKLPKAFWLYLLAVALFAL-GNFSFAFLILRAQE-LGLSAALIPLLYALFN 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1144656267 256 ACHALAqAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFAL 305
Cdd:cd17370   245 LVYALA-AYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLG 293
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 35-297 1.96e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.61  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  35 ATGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGiTGANVAVA 114
Cdd:cd17333    25 AFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAG-LGAGILDT 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 115 TAYVTDVTAEP-DRARRFGQLGAMMGIGFIAGPLIGGLLGA--LHLRAPFVAAALLNALNLVLVWRVLPESRPRSAGGGR 191
Cdd:cd17333   104 GANTFVGALFEeSSATRLNVLHGFFGLGALIGPLIATSLLTseLSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 192 TAGALNPFAnLRRLSGAPALapLVGIYVIVALVSQAPATLWI-LYGQEHFGWSTPVAGLSLAGYGACHALAqAFAIGPLI 270
Cdd:cd17333   184 SVGAFSASA-SRLLRNPSII--LGALALFLYVGAETAFSSWVpSYLVEKKHVSDGLAGYLLSGFWVGITIG-RLLGGPIS 259

                         250       260
                  ....*....|....*....|....*..
gi 1144656267 271 ARLGERRALALGLAGDALGLAVIAFAT 297
Cdd:cd17333   260 RRIKPHTLLVLSGSGALLGLLILLLAP 286
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 8-305 2.16e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267   8 ILATVLLDAIGVGIVMPILPglLRSLAATGSTDTHYGVLLALYAFAQFLCAPLLGALSDR-FGRRPVLLASLAGAALDYL 86
Cdd:cd17471     1 LLLATLLTGLAGAFVLPYLS--LFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  87 LMALAPTLAW-LYVGRLIAGITGANVAVATAYVTDVTAEP---DRARRFGQLGAMMGIGFIAGPLIGG-LLGALHLRAPF 161
Cdd:cd17471    79 LFAFLRNYWVlLLVGVVLLSLGAAAFPQLFALAREYADRSsgrDATLFNSVLRAAFSLAWVIGPPLAFlLLDVLGFTGLF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 162 VAAALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANlrrlsgaPALAPLVGIYVIVALVSQAPATLWILYGQEHFG 241
Cdd:cd17471   159 LLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVN-------RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELG 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1144656267 242 WSTPVAGLsLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWVPFAL 305
Cdd:cd17471   232 GSESWVGL-LFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIAL 294
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
60-298 2.76e-03

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 39.15  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  60 LLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGIT-GANVAVATAYVTDVTAEPDRARrfgqLGAMM 138
Cdd:PRK15402   67 LLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGlCFIGAVGYAAIQESFEEADAIK----ITALM 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 139 GIGFIAGPLIGGLLGALHL-----RAPFVAAALLNALNLVLVWRVLPES----RPRSAGGGRTAGALNPFANLRRLSGAP 209
Cdd:PRK15402  143 ANVALLAPLLGPLVGAALIhvlpwRGMFVLFAALAALSFFGLWRAMPETagrvGEKLSLKELGRDYKLVLKNRRFVAGAL 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 210 ALaPLVGIYVIvALVSQAPAtlwILYGQEHFG------WSTPVAGLSLAGygachalaqAFAIGPLIARLGERRALALGL 283
Cdd:PRK15402  223 AL-GLVSLPLL-AWIALSPV---ILISGEQLSsyeyglLQVPVFGALIAG---------NLTLARLTSRRPLRSLIRMGL 288

                         250
                  ....*....|....*
gi 1144656267 284 AGDALGLAVIAFATA 298
Cdd:PRK15402  289 WPMVAGLLLAALATV 303
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 33-301 3.14e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 38.98  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  33 LAATGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAgaaldYLLMALAPTLAWLYVGRLIAGIT----- 107
Cdd:COG2270    44 LGDPAAATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFT-----LLGVLATAALFFVAPGGLWLGLLlfvla 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 108 -----GANVAVAtAYVTDVTAEPDRAR------RFGQLGAMMG-----IGFIAGPLIGGLLGALHLRAPFVAAALLNALN 171
Cdd:COG2270   119 nigfeGSLVFYN-AFLPDIATPEEIGRvsglgwALGYLGGVLLllinlALFLKPEAFGLPDAGEAVRISFLLTALWWLLF 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 172 LVLVWRVLPEsRPRSAGGGRTAGALNPFANLRRLSGAPALAPLVGIYVIV-ALVSQAPATLWIL---YGQEHFGWSTPVA 247
Cdd:COG2270   198 ALPLFLFLPE-RPRPGPAPPRGAVRAGFRELRRTLRELRRYRDLLRFLLAyFFYRDGVQTVIAFagiYAAGVLGFSTTEL 276

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1144656267 248 GLSLAGYGACHALAqAFAIGPLIARLGERRALALGLAGDALGLAVIAFATAAWV 301
Cdd:COG2270   277 IVFGLLVQIVAALG-ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALA 329
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 34-301 3.62e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 38.78  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  34 AATGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVAV 113
Cdd:cd17393    27 DRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 114 A-TAYVTDVTAEPDRARRFGqLGAMMGIGFIAGPLIGGLLGALHL--RAPFVAAALLNALNLVLVWRVLPESRPRSAGGG 190
Cdd:cd17393   107 AmNAQGVAVERAYGRPIMSS-LHAMWSLGGLAGALLGAAAIGAGVspGVHLLAAAVLLLLAALVAIRALLPGTGEAAEDR 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267 191 RTAGALNPFANLRRlsgapALAPLVGIYVIVALVSQAPATLWILYGQEHFGWSTPVAGLSLAGYGACHALAQAFAiGPLI 270
Cdd:cd17393   186 PDGAGKPGFLLPNR-----LLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFG-DRLV 259

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1144656267 271 ARLGERRALALGLAGDALGLAVIAFATAAWV 301
Cdd:cd17393   260 DRFGDVAVLRAGALLAALGLLLALLAPSVWV 290
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 11-155 3.78e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 38.34  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  11 TVLLDAIGVGIVMPILPGLLRSLAATGSTdthYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMAL 90
Cdd:cd17365     7 IIVLDGFDLAVMGFVAPALAQDWGLSPAQ---LGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1144656267  91 APTLAWLYVGRLIAGI-TGANVAVATAyvtdVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGAL 155
Cdd:cd17365    84 AQSVLQLALLRFLTGLgLGAAMPNAIT----LVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAA 145
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 52-129 4.41e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 38.41  E-value: 4.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  52 FAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGItGANVAVATA--YVTDVTAEPDRAR 129
Cdd:cd17360    46 AGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGL-GVGIASMTVplYIAEAAPPRIRGR 124
Sugar_tr pfam00083
Sugar (and other) transporter;
27-153 4.46e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 38.41  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  27 PGLLRSLAATGSTDTHYGVLLALYAFAQFLCAPLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLY---VGRLI 103
Cdd:pfam00083  32 FGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYqliVGRVL 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1144656267 104 AGI-TGANVAVATAYVTDVTaePDRARrfGQLGAMMGIGFIAGPLIGGLLG 153
Cdd:pfam00083 112 VGIgVGGASVLAPMYISEIA--PKKLR--GALGSLYQLAITFGILLAYIFG 158
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
60-212 8.11e-03

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 37.50  E-value: 8.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144656267  60 LLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANVA-VATAYVTDVTAEPDRARRFGQLGAMM 138
Cdd:PRK15403   70 LLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIAtVGYVTVQEAFGQTKGIKLMAIITSIV 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1144656267 139 GIGFIAGPLIG-GLLGALHLRAPFVAAALLNALNLVLVWRVLPESRPRSAGGGRTAGALNPFANLRR----LSGAPALA 212
Cdd:PRK15403  150 LVAPIIGPLSGaALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRnrlfLTGAATLS 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH